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Conserved domains on  [gi|985801722|ref|NP_001306887|]
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enoyl-CoA hydratase domain-containing protein 2, mitochondrial isoform 4 [Homo sapiens]

Protein Classification

Clp protease/crotonase-like domain-containing protein( domain architecture ID 581041)

Clp protease/crotonase-like domain-containing protein similar to Oryza sativa enoyl-CoA delta isomerase which plays a role in fatty acid metabolism, which involves stabilization of an enolate anion intermediate derived from an acyl-CoA substrate

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
crotonase-like super family cl23717
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
1-215 3.83e-71

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


The actual alignment was detected with superfamily member PLN02600:

Pssm-ID: 474030 [Multi-domain]  Cd Length: 251  Bit Score: 216.98  E-value: 3.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLR----------- 69
Cdd:PLN02600  10 LDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstfsslealsi 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------------GLMNDIA-------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PLN02600  90 ptiavvegaalggGLELALScdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREAASMGL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PLN02600 170 VNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGLAAFAEKRK 245

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PLN02600 246 PVYTGK 251
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
1-215 3.83e-71

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 216.98  E-value: 3.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLR----------- 69
Cdd:PLN02600  10 LDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstfsslealsi 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------------GLMNDIA-------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PLN02600  90 ptiavvegaalggGLELALScdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREAASMGL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PLN02600 170 VNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGLAAFAEKRK 245

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PLN02600 246 PVYTGK 251
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
1-208 8.66e-53

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 169.96  E-value: 8.66e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE-REQMSEAEVGVFVQRLRGLMNDI---- 75
Cdd:COG1024   14 LNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLT-GAGKAFCAGADLKElAAAADPEEARAFARGLQRLFRALrrlp 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ---------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:COG1024   93 kpviaavngaalggglelalacdlriaAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAEEALELG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKR 208
Cdd:COG1024  173 LVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFLEKR 248
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
1-215 9.61e-36

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 126.32  E-value: 9.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722    1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGvKGVFCAGADLKEREQMSEAEVGVF-------VQRLR---- 69
Cdd:pfam00378  11 LNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYrenvldlWTLLYtcpk 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   70 -----------------GLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:pfam00378  90 pviaavngyaigggcelALACDIiiaADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEALKWGL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  130 VNHAVAQNEEGDaayqRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:pfam00378 170 VDKVVPEDQLLD----EARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEKRK 245

                  ....*.
gi 985801722  210 PKFVGK 215
Cdd:pfam00378 246 PPWEDQ 251
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
1-154 3.83e-35

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 123.05  E-value: 3.83e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQMSEA--EVGVFVQRLRGLMNDI--- 75
Cdd:cd06558   14 LNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLT-GAGKAFCAGADLKELAALSDAgeEARAFIRELQELLRALlrl 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ----------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVL 127
Cdd:cd06558   93 pkpviaavngaalggglelalacdiriaAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISAEEALEL 172
                        170       180
                 ....*....|....*....|....*..
gi 985801722 128 GLVNHAVaqneEGDAAYQRARALAQEI 154
Cdd:cd06558  173 GLVDEVV----PDEELLAAALELARRL 195
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
1-171 4.72e-14

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 70.25  E-value: 4.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722    1 MNRPSAR-NALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGAD---------LKEREQMSEaEVGVFVQRLR- 69
Cdd:TIGR02441  28 IDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADiqmiaacktAQEVTQLSQ-EGQEMFERIEk 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   70 ----------------GLMNDIA---------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEA 124
Cdd:TIGR02441 107 sqkpivaaisgsclggGLELALAchyriatkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIRADRA 186
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 985801722  125 HVLGLVNHAVAQNEEG-DAAYQRARALAQEILPQAPIAVRLGKVAIDR 171
Cdd:TIGR02441 187 KKMGIVDQLVDPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
 
Name Accession Description Interval E-value
PLN02600 PLN02600
enoyl-CoA hydratase
1-215 3.83e-71

enoyl-CoA hydratase


Pssm-ID: 178210 [Multi-domain]  Cd Length: 251  Bit Score: 216.98  E-value: 3.83e-71
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLR----------- 69
Cdd:PLN02600  10 LDRPEAKNAIGKEMLRGLRSAFEKIQADASARVVMLRSSVPGVFCAGADLKERRKMSPSEVQKFVNSLRstfsslealsi 89
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------------GLMNDIA-------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PLN02600  90 ptiavvegaalggGLELALScdlricgEEAVFGLPETGLAIIPGAGGTQRLPRLVGRSRAKELIFTGRRIGAREAASMGL 169
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PLN02600 170 VNYCVPAGE----AYEKALELAQEINQKGPLAIKMAKKAINEGSEVDMASGLEIEEECYEQVLKTKDRLEGLAAFAEKRK 245

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PLN02600 246 PVYTGK 251
PRK07657 PRK07657
enoyl-CoA hydratase; Provisional
1-215 7.82e-68

enoyl-CoA hydratase; Provisional


Pssm-ID: 181069 [Multi-domain]  Cd Length: 260  Bit Score: 208.82  E-value: 7.82e-68
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDI----- 75
Cdd:PRK07657  19 LNRPRAANALSLALLEELQNILTQINEEANVRVVILTGAGEKAFCAGADLKERAGMNEEQVRHAVSLIRTTMEMVeqlpq 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 --------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PRK07657  99 pviaaingialggglelalacdfriaAESASLGLTETTLAIIPGAGGTQRLPRLIGVGRAKELIYTGRRISAQEAKEIGL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PRK07657 179 VEFVVPAHL----LEEKAIEIAEKIASNGPIAVRQAKEAISNGIQVDLHTGLQIEKQAYEGTIPTKDRLEGLQAFKEKRK 254

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PRK07657 255 PMYKGE 260
CaiD COG1024
Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase ...
1-208 8.66e-53

Enoyl-CoA hydratase/carnithine racemase [Lipid transport and metabolism]; Enoyl-CoA hydratase/carnithine racemase is part of the Pathway/BioSystem: Fatty acid biosynthesis


Pssm-ID: 440647 [Multi-domain]  Cd Length: 249  Bit Score: 169.96  E-value: 8.66e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE-REQMSEAEVGVFVQRLRGLMNDI---- 75
Cdd:COG1024   14 LNRPEKLNALSLEMLAELAAALDEAEADPDVRVVVLT-GAGKAFCAGADLKElAAAADPEEARAFARGLQRLFRALrrlp 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ---------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:COG1024   93 kpviaavngaalggglelalacdlriaAEDARFGLPEVRLGLIPGGGGTQRLPRLVGLARAKELLLTGRRIDAEEALELG 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKR 208
Cdd:COG1024  173 LVNRVVPD----DELLAAALALAARLAAGPPLALAATKRALNAALEAPLDEALELEAEAFAELFASEDAREGIAAFLEKR 248
PRK05809 PRK05809
short-chain-enoyl-CoA hydratase;
1-215 2.64e-41

short-chain-enoyl-CoA hydratase;


Pssm-ID: 180270 [Multi-domain]  Cd Length: 260  Bit Score: 140.65  E-value: 2.64e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAE---VGVFVQRL-RGLMN--- 73
Cdd:PRK05809  19 INRPKALNALNSETLKELDTVLDDIENDDNVYAVILTGAGEKAFVAGADISEMKDLNEEEgrkFGLLGNKVfRKLENldk 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  74 -----------------------DIASS-AVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PRK05809  99 pviaaingfalgggcelsmacdiRIASEkAKFGQPEVGLGITPGFGGTQRLARIVGPGKAKELIYTGDMINAEEALRIGL 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEEGDAAYqrarALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PRK05809 179 VNKVVEPEKLMEEAK----ALANKIAANAPIAVKLCKDAINRGMQVDIDTAVAIEAEDFGECFSTEDQTEGMTAFVEKRE 254

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PRK05809 255 KNFKNK 260
PRK06688 PRK06688
enoyl-CoA hydratase; Provisional
1-215 5.41e-36

enoyl-CoA hydratase; Provisional


Pssm-ID: 235852 [Multi-domain]  Cd Length: 259  Bit Score: 126.91  E-value: 5.41e-36
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE------REQMSEAEVGVFVQRLRG---- 70
Cdd:PRK06688  20 INRPDKKNALTAAMYQALADALEAAATDPAVRVVVLT-GAGRAFSAGGDIKDfpkappKPPDELAPVNRFLRAIAAlpkp 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  71 -----------------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLV 130
Cdd:PRK06688  99 vvaavngpavgvgvslaLACDLvyaSESAKFSLPFAKLGLCPDAGGSALLPRLIGRARAAEMLLLGEPLSAEEALRIGLV 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 131 NHAVAqNEEGDAAyqrARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTP 210
Cdd:PRK06688 179 NRVVP-AAELDAE---ADAQAAKLAAGPASALRYTKRAINAATLTELEEALAREAAGFGRLLRTPDFREGATAFIEKRKP 254

                 ....*
gi 985801722 211 KFVGK 215
Cdd:PRK06688 255 DFTGF 259
ECH_1 pfam00378
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
1-215 9.61e-36

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase.


Pssm-ID: 395302 [Multi-domain]  Cd Length: 251  Bit Score: 126.32  E-value: 9.61e-36
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722    1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGvKGVFCAGADLKEREQMSEAEVGVF-------VQRLR---- 69
Cdd:pfam00378  11 LNRPEAVNALSAELITELIQALEKLRTDPSVRAVVLTGG-DKAFCAGADLKEMYGEGPAHQALYrenvldlWTLLYtcpk 89
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   70 -----------------GLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:pfam00378  90 pviaavngyaigggcelALACDIiiaADNASFGLNETKLGIIPGAGGTDRLPRIIGHSKAMEMLLLGRRISAQEALKWGL 169
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  130 VNHAVAQNEEGDaayqRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:pfam00378 170 VDKVVPEDQLLD----EARELAEKLAEKSPAALAQLKKALNAKLEDALPTQLEAEARLFYSTFSKDDIIEGLQAFLEKRK 245

                  ....*.
gi 985801722  210 PKFVGK 215
Cdd:pfam00378 246 PPWEDQ 251
PRK09674 PRK09674
enoyl-CoA hydratase-isomerase; Provisional
1-215 2.88e-35

enoyl-CoA hydratase-isomerase; Provisional


Pssm-ID: 182026 [Multi-domain]  Cd Length: 255  Bit Score: 125.26  E-value: 2.88e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE------------REQMSEAEVGVFVQRL 68
Cdd:PRK09674  17 LNRPEARNALNNALLTQLVNELEAAATDTSIGVCVIT-GNARFFAAGADLNEmaekdlaatlndPRPQLWQRLQAFNKPL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  69 RGLMNDIA-----------------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVN 131
Cdd:PRK09674  96 IAAVNGYAlgagcelallcdiviagENARFGLPEITLGIMPGAGGTQRLIRSVGKSLASQMVLTGESITAQQAQQAGLVS 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 132 HaVAQNEegdAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPK 211
Cdd:PRK09674 176 E-VFPPE---LTLERALQLASKIARHSPLALRAAKQALRQSQEVDLQAGLAQERQLFTLLAATEDRHEGISAFLEKRTPD 251

                 ....
gi 985801722 212 FVGK 215
Cdd:PRK09674 252 FKGR 255
crotonase-like cd06558
Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse ...
1-154 3.83e-35

Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase. Many of these play important roles in fatty acid metabolism. In addition to a conserved structural core and the formation of trimers (or dimers of trimers), a common feature in this superfamily is the stabilization of an enolate anion intermediate derived from an acyl-CoA substrate. This is accomplished by two conserved backbone NH groups in active sites that form an oxyanion hole.


Pssm-ID: 119339 [Multi-domain]  Cd Length: 195  Bit Score: 123.05  E-value: 3.83e-35
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQMSEA--EVGVFVQRLRGLMNDI--- 75
Cdd:cd06558   14 LNRPEKRNALSLEMLDELAAALDEAEADPDVRVVVLT-GAGKAFCAGADLKELAALSDAgeEARAFIRELQELLRALlrl 92
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ----------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVL 127
Cdd:cd06558   93 pkpviaavngaalggglelalacdiriaAEDAKFGLPEVKLGLVPGGGGTQRLPRLVGPARARELLLTGRRISAEEALEL 172
                        170       180
                 ....*....|....*....|....*..
gi 985801722 128 GLVNHAVaqneEGDAAYQRARALAQEI 154
Cdd:cd06558  173 GLVDEVV----PDEELLAAALELARRL 195
PRK07658 PRK07658
enoyl-CoA hydratase; Provisional
2-215 1.72e-32

enoyl-CoA hydratase; Provisional


Pssm-ID: 181070 [Multi-domain]  Cd Length: 257  Bit Score: 117.81  E-value: 1.72e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSArNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQ-MSEAEVGVFVQRLRGLMNDI----- 75
Cdd:PRK07658  18 NHPPA-NALSSQVLHELSELLDQVEKDDNVRVVVIH-GEGRFFSAGADIKEFTSvTEAEQATELAQLGQVTFERVekfsk 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 --------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PRK07658  96 pviaaihgaalggglelamschirfaTESAKLGLPELNLGLIPGFAGTQRLPRYVGKAKALEMMLTSEPITGAEALKWGL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRT 209
Cdd:PRK07658 176 VNGVFPEET----LLDDAKKLAKKIAGKSPATTRAVLELLQTTKSSSYYEGVKREAKIFGEVFTSEDAKEGVQAFLEKRK 251

                 ....*.
gi 985801722 210 PKFVGK 215
Cdd:PRK07658 252 PSFSGK 257
PRK08138 PRK08138
enoyl-CoA hydratase; Provisional
1-215 4.15e-31

enoyl-CoA hydratase; Provisional


Pssm-ID: 236162 [Multi-domain]  Cd Length: 261  Bit Score: 114.38  E-value: 4.15e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEreqMSEAE-VGVFVQRLRGLMNDIAS-- 77
Cdd:PRK08138  23 LNRPEARNALNMEVRQQLAEHFTELSEDPDIRAIVL-TGGEKVFAAGADIKE---FATAGaIEMYLRHTERYWEAIAQcp 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  78 -----------------------------SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK08138  99 kpviaavngyalgggcelamhadiivageSASFGQPEIKVGLMPGAGGTQRLVRAVGKFKAMRMALTGCMVPAPEALAIG 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVaqneEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKR 208
Cdd:PRK08138 179 LVSEVV----EDEQTLPRALELAREIARMPPLALAQIKEVVLAGADAPLDAALALERKAFQLLFDSEDQKEGMDAFLEKR 254

                 ....*..
gi 985801722 209 TPKFVGK 215
Cdd:PRK08138 255 KPAYKGK 261
PRK05862 PRK05862
enoyl-CoA hydratase; Provisional
1-212 9.41e-31

enoyl-CoA hydratase; Provisional


Pssm-ID: 180295 [Multi-domain]  Cd Length: 257  Bit Score: 113.21  E-value: 9.41e-31
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEREQMSEAEV--GVF------VQRLR--- 69
Cdd:PRK05862  19 LNRPKALNALNDALMDELGAALAAFDADEGIGAIVI-TGSEKAFAAGADIKEMADLSFMDVykGDYitnwekVARIRkpv 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 ---------------GLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVN 131
Cdd:PRK05862  98 iaavagyalgggcelAMMCDIiiaADTAKFGQPEIKLGVLPGMGGSQRLTRAVGKAKAMDLCLTGRMMDAAEAERAGLVS 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 132 HAVAQNEEGDAAYQRARALAQEILPqapiAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPK 211
Cdd:PRK05862 178 RVVPADKLLDEALAAATTIASFSLP----AVMMAKEAVNRAYETTLAEGLLFERRLFHSLFATEDQKEGMAAFVEKRKPV 253

                 .
gi 985801722 212 F 212
Cdd:PRK05862 254 F 254
PRK06494 PRK06494
enoyl-CoA hydratase; Provisional
1-215 7.12e-29

enoyl-CoA hydratase; Provisional


Pssm-ID: 180591 [Multi-domain]  Cd Length: 259  Bit Score: 108.59  E-value: 7.12e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGV---------------FV 65
Cdd:PRK06494  19 LNRPEVMNALHLDAHFELEEVFDDFAADPEQWVAIVTGAGDKAFSAGNDLKEQAAGGKRGWPEsgfggltsrfdldkpII 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  66 QRLRG----------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNH 132
Cdd:PRK06494  99 AAVNGvamgggfelaLACDLivaAENATFALPEPRVGLAALAGGLHRLPRQIGLKRAMGMILTGRRVTAREGLELGFVNE 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 133 AVAQnEEGDAAyqrARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQN--IPTRDRLEGMAAFREKRTP 210
Cdd:PRK06494 179 VVPA-GELLAA---AERWADDILACSPLSIRASKQAVYRGLEVSLEEAITAQRDYPAVEarRASQDYIEGPKAFAEKRPP 254

                 ....*
gi 985801722 211 KFVGK 215
Cdd:PRK06494 255 RWKGR 259
PRK08252 PRK08252
crotonase/enoyl-CoA hydratase family protein;
1-215 2.28e-26

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181325 [Multi-domain]  Cd Length: 254  Bit Score: 101.99  E-value: 2.28e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLK-----EREQMSEAEVGVFVQR-------- 67
Cdd:PRK08252  18 INRPEARNAVNAAVAQGLAAALDELDADPDLSVGIL-TGAGGTFCAGMDLKafargERPSIPGRGFGGLTERpprkplia 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  68 ------LRG-----LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHA 133
Cdd:PRK08252  97 avegyaLAGgfelaLACDLivaARDAKFGLPEVKRGLVAAGGGLLRLPRRIPYHIAMELALTGDMLTAERAHELGLVNRL 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 134 VAQNEEGDAayqrARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKFV 213
Cdd:PRK08252 177 TEPGQALDA----ALELAERIAANGPLAVAASKRIVVESGDWSEDEMFARQRELIAPVFTSADAKEGATAFAEKRAPVWT 252

                 ..
gi 985801722 214 GK 215
Cdd:PRK08252 253 GK 254
PRK06190 PRK06190
enoyl-CoA hydratase; Provisional
1-206 4.19e-26

enoyl-CoA hydratase; Provisional


Pssm-ID: 235733  Cd Length: 258  Bit Score: 101.20  E-value: 4.19e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKE--------REQMSEAEVGVFVQRLRG-L 71
Cdd:PRK06190  19 LNRPEARNALSAALRRALFAALAEADADDDVDVVVL-TGADPAFCAGLDLKElggdgsayGAQDALPNPSPAWPAMRKpV 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  72 MNDIASSAVMG----------LIETTR----------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVN 131
Cdd:PRK06190  98 IGAINGAAVTGglelalacdiLIASERarfadtharvGILPGWGLSVRLPQKVGIGRARRMSLTGDFLDAADALRAGLVT 177
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 985801722 132 HAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEgMCYAQNIPTRDRLEGMAAFRE 206
Cdd:PRK06190 178 EVVPHDE----LLPRARRLAASIAGNNPAAVRALKASYDDGAAAQTGDALALE-AEAARAHNRSVSPDGIAARRE 247
PRK05980 PRK05980
crotonase/enoyl-CoA hydratase family protein;
1-212 9.24e-25

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180335 [Multi-domain]  Cd Length: 260  Bit Score: 97.91  E-value: 9.24e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKE------------------REQMSEAEVG 62
Cdd:PRK05980  18 LNRPEKLNALNYALIDRLLARLDAIEVDESVRAVILTGAGDRAFSAGADIHEfsasvaagadvalrdfvrRGQAMTARLE 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  63 VFVQRLRGLMNDIA-------SSAVMGLIETTR----------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAH 125
Cdd:PRK05980  98 AFPKPVIAAVNGLAfgggceiTEAVHLAIASERalfakpeirlGMPPTFGGTQRLPRLAGRKRALELLLTGDAFSAERAL 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 126 VLGLVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFR 205
Cdd:PRK05980 178 EIGLVNAVVPH----EELLPAARALARRIIRHSPVAVAAILTAVTRGLNLSIAEGLLIESEQFARMAGSADLREGLAAWI 253

                 ....*..
gi 985801722 206 EKRTPKF 212
Cdd:PRK05980 254 ERRRPAY 260
PRK07511 PRK07511
enoyl-CoA hydratase; Provisional
1-214 5.69e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 181009 [Multi-domain]  Cd Length: 260  Bit Score: 95.45  E-value: 5.69e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLK---EREQMSEAEVGVFVQRLRGLMNDI-- 75
Cdd:PRK07511  18 LSNPGARNALHPDMYAAGIEALNTAERDPSIRAVVL-TGAGGFFCAGGNLNrllENRAKPPSVQAASIDGLHDWIRAIra 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 -----------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK07511  97 fpkpviaavegaaagagfslalacdllvaARDAKFVMAYVKVGLTPDGGGSWFLARALPRQLATELLLEGKPISAERLHA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 127 LGLVNHAVAQNEEGDAAYQRARALAQeilpQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFRE 206
Cdd:PRK07511 177 LGVVNRLAEPGQALAEALALADQLAA----GSPNALARIKSLIADAPEATLAAQLEAERDHFVASLHHADALEGIAAFLE 252

                 ....*...
gi 985801722 207 KRTPKFVG 214
Cdd:PRK07511 253 KRAPDYKR 260
PRK07799 PRK07799
crotonase/enoyl-CoA hydratase family protein;
1-215 6.55e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181122 [Multi-domain]  Cd Length: 263  Bit Score: 95.55  E-value: 6.55e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEREQMSEAEV----GVFVQRLRGLM---- 72
Cdd:PRK07799  20 MNRPEARNALSTEMLRIMVDAWDRVDNDPDIRSCIL-TGAGGAFCAGMDLKAATKKPPGDSfkdgSYDPSRIDALLkgrr 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  73 -----------------------NDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK07799  99 ltkpliaavegpaiaggteilqgTDIrvaGESAKFGISEAKWSLFPMGGSAVRLVRQIPYTVACDLLLTGRHITAAEAKE 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 127 LGLVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFRE 206
Cdd:PRK07799 179 IGLIGHVVPD----GQALDKALELAELINANGPLAVQAILRTIRETEGMHENEAFKIDTKIGIPVFLSEDAKEGPRAFAE 254

                 ....*....
gi 985801722 207 KRTPKFVGK 215
Cdd:PRK07799 255 KRAPNFQGR 263
PRK09076 PRK09076
enoyl-CoA hydratase; Provisional
1-210 7.06e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 236373 [Multi-domain]  Cd Length: 258  Bit Score: 95.37  E-value: 7.06e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSArNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKE---------REqMSEAEVGVF--VQRLR 69
Cdd:PRK09076  18 LNNPPA-NTWTADSLQALKQLVLELNADKDVYALVITGDGEKFFSAGADLNLfadgdkavaRE-MARRFGEAFeaLSAFR 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 G------------------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK09076  96 GvsiaaingyamggglecaLACDIriaEEQAQMALPEASVGLLPCAGGTQNLPWLVGEGWAKRMILCGERVDAATALRIG 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKR 208
Cdd:PRK09076 176 LVEEVVEKGE----AREAALALAQKVANQSPSAVAACKTLIQAARNGPRAAALALERELFVDLFDTEDQREGVNAFLEKR 251

                 ..
gi 985801722 209 TP 210
Cdd:PRK09076 252 AP 253
PRK06127 PRK06127
enoyl-CoA hydratase; Provisional
2-215 8.70e-24

enoyl-CoA hydratase; Provisional


Pssm-ID: 235705  Cd Length: 269  Bit Score: 95.16  E-value: 8.70e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVF----------------- 64
Cdd:PRK06127  27 NNPARHNAMSLDMWEALPQALAAAEDDDAIRVVVLTGAGEKAFVSGADISQFEESRSDAEAVAayeqaveaaqaaladya 106
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  65 ---VQRLRG----------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK06127 107 kptIACIRGycigggmgiaLACDIriaAEDSRFGIPAARLGLGYGYDGVKNLVDLVGPSAAKDLFYTARRFDAAEALRIG 186
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVAQNEEGDAAYQRARALAQeilpQAPIAVRLGKVAIDR----GTEVDIASGMAIEGMCYAqnipTRDRLEGMAAF 204
Cdd:PRK06127 187 LVHRVTAADDLETALADYAATIAG----NAPLTLRAAKRAIAEllkdEPERDMAACQALVAACFD----SEDYREGRAAF 258
                        250
                 ....*....|.
gi 985801722 205 REKRTPKFVGK 215
Cdd:PRK06127 259 MEKRKPVFKGR 269
PRK07509 PRK07509
crotonase/enoyl-CoA hydratase family protein;
2-213 9.63e-24

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181008 [Multi-domain]  Cd Length: 262  Bit Score: 94.95  E-value: 9.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSARNALGNVFVSELLETLAQLREDRQVR-VLLfrSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMN------- 73
Cdd:PRK07509  19 NRPDKMNALDFAMFEELIATIKRLKKDRGIRaVIL--SGEGGAFCAGLDVKSVASSPGNAVKLLFKRLPGNANlaqrvsl 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  74 ----------------------------DI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGT 122
Cdd:PRK07509  97 gwrrlpvpviaalegvcfggglqialgaDIriaAPDTKLSIMEAKWGLVPDMAGTVSLRGLVRKDVARELTYTARVFSAE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 123 EAHVLGLVNHAVaqneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMA 202
Cdd:PRK07509 177 EALELGLVTHVS------DDPLAAALALAREIAQRSPDAIAAAKRLINRSWTASVRALLARESVEQIRLLLGKNQKIAVK 250
                        250
                 ....*....|.
gi 985801722 203 AFREKRTPKFV 213
Cdd:PRK07509 251 AQMKKRAPKFL 261
PRK03580 PRK03580
crotonobetainyl-CoA hydratase;
1-215 1.35e-22

crotonobetainyl-CoA hydratase;


Pssm-ID: 179599 [Multi-domain]  Cd Length: 261  Bit Score: 92.06  E-value: 1.35e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSArNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKERE--QMSEAEVGV--F--VQRLRGL--- 71
Cdd:PRK03580  18 LDRPKA-NAIDAKTSFAMGEVFLNFRDDPELRVAIITGAGEKFFSAGWDLKAAAegEAPDADFGPggFagLTEIFDLdkp 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  72 ----MNDI-----------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLV 130
Cdd:PRK03580  97 viaaVNGYafgggfelalaadfivcADNASFALPEAKLGIVPDSGGVLRLPKRLPPAIANEMVMTGRRMDAEEALRWGIV 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 131 NHAVAQNEEGDaayqRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIP----TRDRLEGMAAFRE 206
Cdd:PRK03580 177 NRVVPQAELMD----RARELAQQLVNSAPLAIAALKEIYRETSEMPVEEAYRYIRSGVLKHYPsvlhSEDALEGPRAFAE 252

                 ....*....
gi 985801722 207 KRTPKFVGK 215
Cdd:PRK03580 253 KRDPVWKGR 261
PRK09245 PRK09245
crotonase/enoyl-CoA hydratase family protein;
1-215 1.43e-22

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181723  Cd Length: 266  Bit Score: 91.96  E-value: 1.43e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNAL-GNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLK---EREQMSEAEVGVFVQRLR------- 69
Cdd:PRK09245  18 MNRPETRNALsDNDAVDALVAACAAINADRSVRAVIL-TGAGTAFSSGGNVKdmrARVGAFGGSPADIRQGYRhgiqrip 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------------------------GLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSG 121
Cdd:PRK09245  97 lalynlevpviaavngpaigagcdlACMCDIriaSETARFAESFVKLGLIPGDGGAWLLPRIIGMARAAEMAFTGDAIDA 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 122 TEAHVLGLVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGM 201
Cdd:PRK09245 177 ATALEWGLVSRVVPA----DQLLPAARALAERIAANPPHALRLTKRLLREGQHASLDTLLELSAAYQALAHHTADHREAV 252
                        250
                 ....*....|....
gi 985801722 202 AAFREKRTPKFVGK 215
Cdd:PRK09245 253 DAFLEKRPPVFTGR 266
PRK06144 PRK06144
enoyl-CoA hydratase; Provisional
2-215 4.49e-22

enoyl-CoA hydratase; Provisional


Pssm-ID: 180424 [Multi-domain]  Cd Length: 262  Bit Score: 90.44  E-value: 4.49e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRlrglmndiASSAVM 81
Cdd:PRK06144  24 NRPAARNAMTWAMYEGLAEICEAIAADPSIRAVVLRGAGDKAFVAGTDIAQFRAFSTAEDAVAYER--------RIDRVL 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  82 GLIETTR--------GLLPGAG-----------GT----------------------QRLPRCLGVALAKELIFTGRRLS 120
Cdd:PRK06144  96 GALEQLRvptiaaiaGACVGGGaaiaaacdlriATpsarfgfpiartlgnclsmsnlARLVALLGAARVKDMLFTARLLE 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 121 GTEAHVLGLVNHAVaqneEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAqnipTRDRLEG 200
Cdd:PRK06144 176 AEEALAAGLVNEVV----EDAALDARADALAELLAAHAPLTLRATKEALRRLRREGLPDGDDLIRMCYM----SEDFREG 247
                        250
                 ....*....|....*
gi 985801722 201 MAAFREKRTPKFVGK 215
Cdd:PRK06144 248 VEAFLEKRPPKWKGR 262
PRK06495 PRK06495
enoyl-CoA hydratase/isomerase family protein;
1-215 1.61e-21

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 168580 [Multi-domain]  Cd Length: 257  Bit Score: 88.98  E-value: 1.61e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSArNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEREQMSEAEvGVFVQRLR----------- 69
Cdd:PRK06495  19 LDNPPV-NALSRELRDELIAVFDEISERPDVRVVVL-TGAGKVFCAGADLKGRPDVIKGP-GDLRAHNRrtrecfhaire 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 ------------------GLM--NDI---ASSAVMGLIETTRGLlpgAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK06495  96 cakpviaavngpalgaglGLVasCDIivaSENAVFGLPEIDVGL---AGGGKHAMRLFGHSLTRRMMLTGYRVPAAELYR 172
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 127 LGLVNHAVAqneeGDAAYQRARALAQEILPQAPIAVRLGKVAIdrgtevDIASGMAI-EGMCYAQNIP-----TRDRLEG 200
Cdd:PRK06495 173 RGVIEACLP----PEELMPEAMEIAREIASKSPLATRLAKDAL------NTIENMSLrDGYRYEQDITaklakTEDAKEA 242
                        250
                 ....*....|....*
gi 985801722 201 MAAFREKRTPKFVGK 215
Cdd:PRK06495 243 QRAFLEKRPPVFKGR 257
PRK06142 PRK06142
crotonase/enoyl-CoA hydratase family protein;
1-214 1.72e-20

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 235714  Cd Length: 272  Bit Score: 86.57  E-value: 1.72e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADL-----------KEREQMSEAEVGVFVQRLR 69
Cdd:PRK06142  21 LNRPGKGNAMNPAFWSELPEIFRWLDADPEVRAVVLSGSGKH-FSYGIDLpamagvfgqlgKDGLARPRTDLRREILRLQ 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 GLMNDIAS------SAVMG--------LI-----------------ETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRR 118
Cdd:PRK06142 100 AAINAVADcrkpviAAVQGwcigggvdLIsacdmryasadakfsvrEVDLGMVADVGSLQRLPRIIGDGHLRELALTGRD 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 119 LSGTEAHVLGLVNHAVaqnEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRL 198
Cdd:PRK06142 180 IDAAEAEKIGLVNRVY---DDADALLAAAHATAREIAAKSPLAVRGTKEVLDYMRDHRVADGLRYVATWNAAMLPSKDLT 256
                        250
                 ....*....|....*.
gi 985801722 199 EGMAAFREKRTPKFVG 214
Cdd:PRK06142 257 EAIAAHMEKRPPEFTG 272
PRK08139 PRK08139
enoyl-CoA hydratase; Validated
1-210 3.23e-20

enoyl-CoA hydratase; Validated


Pssm-ID: 181249  Cd Length: 266  Bit Score: 85.76  E-value: 3.23e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKgVFCAGADLKEreqMSEAEVGVFVQRLRGLMND------ 74
Cdd:PRK08139  26 LNRPQAFNALSEAMLAALQAALDAIAADPSVRVVVLAAAGK-AFCAGHDLKE---MRAARGLAYFRALFARCSRvmqaiv 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  75 ------------IASSAVMGLI---------ETTR--------GLL---PGAGgtqrLPRCLGVALAKELIFTGRRLSGT 122
Cdd:PRK08139 102 alpqpviarvhgIATAAGCQLVascdlavaaDTARfavpgvniGLFcstPMVA----LSRNVPRKQAMEMLLTGEFIDAA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 123 EAHVLGLVNHAVAQNEEGDAAyqraRALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMA 202
Cdd:PRK08139 178 TAREWGLVNRVVPADALDAAV----ARLAAVIAAKSPAAVRIGKEAFYRQAEMPLADAYAYAGDVMAENMMAEDAEEGID 253

                 ....*...
gi 985801722 203 AFREKRTP 210
Cdd:PRK08139 254 AFLEKRPP 261
PLN02664 PLN02664
enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase
1-212 5.69e-20

enoyl-CoA hydratase/delta3,5-delta2,4-dienoyl-CoA isomerase


Pssm-ID: 178269 [Multi-domain]  Cd Length: 275  Bit Score: 85.34  E-value: 5.69e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKE----REQMSEAEVGVFVQRLR------- 69
Cdd:PLN02664  23 LNRPSQRNALSLDFFTEFPKALSSLDQNPNVSVIIL-SGAGDHFCSGIDLKTlnsiSEQSSSGDRGRSGERLRrkikflq 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 ----------------------GLMNDIASS---------AVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRR 118
Cdd:PLN02664 102 daitaieqcrkpviaaihgaciGGGVDIVTAcdirycsedAFFSVKEVDLAITADLGTLQRLPSIVGYGNAMELALTGRR 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 119 LSGTEAHVLGLVNHAVAQNEEGDaayQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRL 198
Cdd:PLN02664 182 FSGSEAKELGLVSRVFGSKEDLD---EGVRLIAEGIAAKSPLAVTGTKAVLLRSRELSVEQGLDYVATWNSAMLVSDDLN 258
                        250
                 ....*....|....
gi 985801722 199 EGMAAFREKRTPKF 212
Cdd:PLN02664 259 EAVSAQIQKRKPVF 272
PRK06210 PRK06210
enoyl-CoA hydratase; Provisional
1-215 1.99e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 180472  Cd Length: 272  Bit Score: 83.60  E-value: 1.99e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADLKEREQMSEAEV------------------- 61
Cdd:PRK06210  21 LNRPDRLNAWTPVMEAEVYAAMDRAEADPAVRVIVLTGAGRG-FCAGADMGELQTIDPSDGrrdtdvrpfvgnrrpdyqt 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  62 -GVFVQRLR------------------GLMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRL 119
Cdd:PRK06210 100 rYHFLTALRkpviaaingacagiglthALMCDVrfaADGAKFTTAFARRGLIAEHGISWILPRLVGHANALDLLLSARTF 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 120 SGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPqAPIAVRLGKVAIDRGTEVDIASGMAIEGMcyAQNIPTRDRLE 199
Cdd:PRK06210 180 YAEEALRLGLVNRVVPPDELMERTLAYAEDLARNVSP-ASMAVIKRQLYEDAFQTLAEATARANREM--HESLQRPDFIE 256
                        250
                 ....*....|....*.
gi 985801722 200 GMAAFREKRTPKFVGK 215
Cdd:PRK06210 257 GVASFLEKRPPRFPGL 272
PRK11423 PRK11423
methylmalonyl-CoA decarboxylase; Provisional
1-215 2.10e-19

methylmalonyl-CoA decarboxylase; Provisional


Pssm-ID: 236908 [Multi-domain]  Cd Length: 261  Bit Score: 83.54  E-value: 2.10e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRqVRVLLFRSGVKG-VFCAGADLKEREQMSEAEVGvFVQRLRGLMNDIAS-- 77
Cdd:PRK11423  19 FNNPAKRNALSKVLIDDLMQALSDLNRPE-IRVVILRAPSGSkVWSAGHDIHELPSGGRDPLS-YDDPLRQILRMIQKfp 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  78 SAVMGLIE---------------------TTR--------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK11423  97 KPVIAMVEgsvwggafelimscdliiaasTSTfamtpanlGVPYNLSGILNFTNDAGFHIVKEMFFTASPITAQRALAVG 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHaVAQNEEGDAAyqrARALAQEILPQAPIAVRLGKvaidrgTEVDI---ASGMAIEGMCYAQNI-----PTRDRLEG 200
Cdd:PRK11423 177 ILNH-VVEVEELEDF---TLQMAHHISEKAPLAIAVIK------EQLRVlgeAHPMNPDEFERIQGLrravyDSEDYQEG 246
                        250
                 ....*....|....*
gi 985801722 201 MAAFREKRTPKFVGK 215
Cdd:PRK11423 247 MNAFLEKRKPVFVGH 261
fadJ PRK11154
fatty acid oxidation complex subunit alpha FadJ;
8-149 2.17e-19

fatty acid oxidation complex subunit alpha FadJ;


Pssm-ID: 236864 [Multi-domain]  Cd Length: 708  Bit Score: 85.72  E-value: 2.17e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   8 NALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLK---------EREQMSEAEVGVF--VQRLR------- 69
Cdd:PRK11154  29 NTLKAEFAEQVRAILKQLREDKELKGVVFISGKPDNFIAGADINmlaacktaqEAEALARQGQQLFaeIEALPipvvaai 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------GLMNDIA---------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHA 133
Cdd:PRK11154 109 hgaclggGLELALAchyrvctddPKTVLGLPEVQLGLLPGSGGTQRLPRLIGVSTALDMILTGKQLRAKQALKLGLVDDV 188
                        170
                 ....*....|....*.
gi 985801722 134 VAQNEEGDAAYQRARA 149
Cdd:PRK11154 189 VPHSILLEVAVELAKK 204
PRK05995 PRK05995
enoyl-CoA hydratase; Provisional
1-215 3.82e-19

enoyl-CoA hydratase; Provisional


Pssm-ID: 235664 [Multi-domain]  Cd Length: 262  Bit Score: 82.67  E-value: 3.82e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEREQM---SEAEVGVFVQRLRGL------ 71
Cdd:PRK05995  19 LNRPDVRNAFNETVIAELTAAFRALDADDSVRAVVL-AGAGKAFCAGADLNWMKKMagySDDENRADARRLADMlraiyr 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  72 ----------------------MNDIA---SSAVMGLIETTRGLLPgaggTQRLP---RCLGVALAKELIFTGRRLSGTE 123
Cdd:PRK05995  98 cpkpviarvhgdayaggmglvaACDIAvaaDHAVFCLSEVRLGLIP----ATISPyviRAMGERAARRYFLTAERFDAAE 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 124 AHVLGLVNHAVAQnEEGDAAYQrarALAQEILPQAPIAVRLGKVAIDrgtevDIAsGMAIEGMCYAQnipTRDRL----- 198
Cdd:PRK05995 174 ALRLGLVHEVVPA-EALDAKVD---ELLAALVANSPQAVRAGKRLVR-----DVA-GRPIDAALIAD---TASRIalira 240
                        250       260
                 ....*....|....*....|..
gi 985801722 199 -----EGMAAFREKRTPKFVGK 215
Cdd:PRK05995 241 teearEGVAAFLEKRKPAWRGR 262
PRK08150 PRK08150
crotonase/enoyl-CoA hydratase family protein;
1-211 9.24e-18

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 181254  Cd Length: 255  Bit Score: 78.91  E-value: 9.24e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLlfrSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDIA---- 76
Cdd:PRK08150  17 LNRPAKRNALNDGLIAALRAAFARLPEGVRAVVL---HGEGDHFCAGLDLSELRERDAGEGMHHSRRWHRVFDKIQygrv 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  77 ---------------------------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PRK08150  94 pviaalhgavvggglelasaahirvadESTYFALPEGQRGIFVGGGGSVRVPRLIGVARMTDMMLTGRVYDAQEGERLGL 173
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 130 VNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMC--YAQNIP-TRDRLegmAAFRE 206
Cdd:PRK08150 174 AQYLVPAGE----ALDKAMELARRIAQNAPLTNFAVLNALPRIADMSADDGLFVESLMaaVAQSAPeAKERL---RAFLE 246

                 ....*
gi 985801722 207 KRTPK 211
Cdd:PRK08150 247 KKAAK 251
PLN02888 PLN02888
enoyl-CoA hydratase
1-211 1.08e-17

enoyl-CoA hydratase


Pssm-ID: 215480  Cd Length: 265  Bit Score: 79.03  E-value: 1.08e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKEREQMSEAEVG-------VFVQRLR---- 69
Cdd:PLN02888  25 INRPKALNALTRPMMVELAAAFKRLDEDDSVKVIIL-TGSGRAFCSGVDLTAAEEVFKGDVKdvetdpvAQMERCRkpii 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 GLMNDIASSAVMGL---------------IETTR--GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNH 132
Cdd:PLN02888 104 GAINGFAITAGFEIalacdilvasrgakfIDTHAkfGIFPSWGLSQKLSRIIGANRAREVSLTAMPLTAETAERWGLVNH 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 133 AVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIE---GMCYAQNIpTRDRLEGMAAFREKRT 209
Cdd:PLN02888 184 VVEESE----LLKKAREVAEAIIKNNQGMVLRYKSVINDGLKLDLGHALQLEkerAHDYYNGM-TKEQFQKMQEFIAGRS 258

                 ..
gi 985801722 210 PK 211
Cdd:PLN02888 259 SK 260
PRK06563 PRK06563
crotonase/enoyl-CoA hydratase family protein;
1-215 2.70e-17

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180625 [Multi-domain]  Cd Length: 255  Bit Score: 77.69  E-value: 2.70e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRV-LLFRSGvkGVFCAGADLKE--------REQMSEAEVGVF--VQRLR 69
Cdd:PRK06563  14 LDRPAKRNAFDSAMLDDLALALGEYEADDELRVaVLFAHG--EHFTAGLDLADvapklaagGFPFPEGGIDPWgtVGRRL 91
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 G-------------------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVL 127
Cdd:PRK06563  92 SkplvvavqgycltlgielmLAADIvvaADNTRFAQLEVQRGILPFGGATLRFPQAAGWGNAMRYLLTGDEFDAQEALRL 171
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 128 GLVNHAVAQNEEgdaaYQRARALAQEILPQAPIAVRL----GKVAIDRGTEVDIASGMAIegmcYAQNIPTRDRLEGMAA 203
Cdd:PRK06563 172 GLVQEVVPPGEQ----LERAIELAERIARAAPLGVQAtlasARAAVREGEAAAAAQLPPE----LRPLFTSEDAKEGVQA 243
                        250
                 ....*....|..
gi 985801722 204 FREKRTPKFVGK 215
Cdd:PRK06563 244 FLERRPARFKGR 255
PRK09120 PRK09120
p-hydroxycinnamoyl CoA hydratase/lyase; Validated
1-211 1.48e-16

p-hydroxycinnamoyl CoA hydratase/lyase; Validated


Pssm-ID: 236383  Cd Length: 275  Bit Score: 75.82  E-value: 1.48e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE--REQMSEAEVGV---------FVQRLR 69
Cdd:PRK09120  23 LNRPEKRNAMSPTLNREMIDVLDALEFDDDAGVLVLT-GAGDAWSAGMDLKEyfRETDAQPEILQerirreaygWWRRLR 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------GLMN--------------DIA---SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAH 125
Cdd:PRK09120 102 wyqkptiAMVNgwcfgggfsplvacDLAiaaDEAQFGLSEINWGIPPGGGVSKAMADTVGHRDALYYIMTGETFTGRKAA 181
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 126 VLGLVNHAV--AQNEEgdaayqRARALAQEILPQAPIAVRLGKVAIDRGTEvdiasgmaiegMCYAQNI----------- 192
Cdd:PRK09120 182 EMGLVNESVplAQLRA------RTRELAAKLLEKNPVVLRAAKDGFKRVRE-----------LTWDQAEdylyakleqan 244
                        250       260
                 ....*....|....*....|..
gi 985801722 193 ---PTRDRLEGMAAFREKRTPK 211
Cdd:PRK09120 245 sldPEGGREEGLKQFLDDKSYK 266
PRK08260 PRK08260
enoyl-CoA hydratase; Provisional
1-215 4.82e-16

enoyl-CoA hydratase; Provisional


Pssm-ID: 236206 [Multi-domain]  Cd Length: 296  Bit Score: 74.66  E-value: 4.82e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADL-------------KEREQMSEAEVGVFVQR 67
Cdd:PRK08260  19 LNRPDKLNAFTVTMARELIEAFDAADADDAVRAVIV-TGAGRAFCAGADLsaggntfdldaprTPVEADEEDRADPSDDG 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  68 LRG--------------------------------LMNDI--AS-SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKEL 112
Cdd:PRK08260  98 VRDgggrvtlrifdslkpviaavngpavgvgatmtLAMDIrlAStAARFGFVFGRRGIVPEAASSWFLPRLVGLQTALEW 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 113 IFTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARALAQEilpQAPIAVRLGKVAIDRGTEVDI-ASGMAIEGMCYAQN 191
Cdd:PRK08260 178 VYSGRVFDAQEALDGGLVRSVHPPDELLPAARALAREIADN---TSPVSVALTRQMMWRMAGADHpMEAHRVDSRAIYSR 254
                        250       260
                 ....*....|....*....|....
gi 985801722 192 IPTRDRLEGMAAFREKRTPKFVGK 215
Cdd:PRK08260 255 GRSGDGKEGVSSFLEKRPAVFPGK 278
PRK08140 PRK08140
enoyl-CoA hydratase; Provisional
1-215 1.92e-15

enoyl-CoA hydratase; Provisional


Pssm-ID: 236163  Cd Length: 262  Bit Score: 72.64  E-value: 1.92e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLrEDRQVRVLLFRSGVKGvFCAGADLKERE-----------QMSEAEVGVFVQRLR 69
Cdd:PRK08140  19 LNRPDKLNSFTREMHRELREALDQV-EDDGARALLLTGAGRG-FCAGQDLADRDvtpggampdlgESIETFYNPLVRRLR 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 GL-------MNDIASSA------VMGLIETTR-----------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAH 125
Cdd:PRK08140  97 ALplpviaaVNGVAAGAganlalACDIVLAARsasfiqafvkiGLVPDSGGTWFLPRLVGMARALGLALLGEKLSAEQAE 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 126 VLGLVNHAVAQNEEGDAAYQRARALAQeilpQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFR 205
Cdd:PRK08140 177 QWGLIWRVVDDAALADEAQQLAAHLAT----QPTRGLALIKQAMNASATNTLDAQLDLERDLQREAGRSADYAEGVSAFL 252
                        250
                 ....*....|
gi 985801722 206 EKRTPKFVGK 215
Cdd:PRK08140 253 EKRAPRFTGR 262
fa_ox_alpha_mit TIGR02441
fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of ...
1-171 4.72e-14

fatty acid oxidation complex, alpha subunit, mitochondrial; Members represent alpha subunit of mitochondrial multifunctional fatty acid degradation enzyme complex. Subunit activities include: enoyl-CoA hydratase (EC 4.2.1.17) _ 3-hydroxyacyl-CoA dehydrogenase (EC 1.1.1.35). Some characterization in human (SP:P40939), pig (SP:Q29554), and rat (SP:Q64428). The beta subunit has activity: acetyl-CoA C-acyltransferase (EC 2.3.1.16).


Pssm-ID: 131494 [Multi-domain]  Cd Length: 737  Bit Score: 70.25  E-value: 4.72e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722    1 MNRPSAR-NALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGAD---------LKEREQMSEaEVGVFVQRLR- 69
Cdd:TIGR02441  28 IDSPNSKvNTLSKELFAEFKEVMNELWTNEAIKSAVLISGKPGSFVAGADiqmiaacktAQEVTQLSQ-EGQEMFERIEk 106
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   70 ----------------GLMNDIA---------SSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEA 124
Cdd:TIGR02441 107 sqkpivaaisgsclggGLELALAchyriatkdRKTLLGLPEVMLGLLPGAGGTQRLPKLTGVPAALDMMLTGKKIRADRA 186
                         170       180       190       200
                  ....*....|....*....|....*....|....*....|....*...
gi 985801722  125 HVLGLVNHAVAQNEEG-DAAYQRARALAQEILPQAPIAVRLGKVAIDR 171
Cdd:TIGR02441 187 KKMGIVDQLVDPLGPGlKPAEENTIEYLEEVAVKFAQGLANGKLSINR 234
PRK07468 PRK07468
crotonase/enoyl-CoA hydratase family protein;
1-215 6.20e-14

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 180987 [Multi-domain]  Cd Length: 262  Bit Score: 68.55  E-value: 6.20e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLK-EREQMSE------AEVGVFVQRLR---- 69
Cdd:PRK07468  20 LNRPEKHNALSARMIAELTTAARRLAADAAVRVVVL-TGAGKSFCAGGDLGwMRAQMTAdratriEEARRLAMMLKalnd 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 ------------------GLMN--DIA---SSAVMGLIETTRGLLPGAGGTQRLPRcLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK07468  99 lpkpligriqgqafgggvGLISvcDVAiavSGARFGLTETRLGLIPATISPYVVAR-MGEANARRVFMSARLFDAEEAVR 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 127 LGLVNHAVAQnEEGDAAYQRaralaqEILPQ---APIAV-RLGKVAIDRGTEVDIAS-GMAIEGMcyAQNIPTRDRLEGM 201
Cdd:PRK07468 178 LGLLSRVVPA-ERLDAAVEA------EVTPYlscAPGAVaAAKALVRALGAPIDEAViDATIEAL--ADTWETEEAREGI 248
                        250
                 ....*....|....
gi 985801722 202 AAFREKRTPKFVGK 215
Cdd:PRK07468 249 AAFFDKRAPAWRGG 262
PRK07659 PRK07659
enoyl-CoA hydratase; Provisional
1-215 6.76e-14

enoyl-CoA hydratase; Provisional


Pssm-ID: 236073 [Multi-domain]  Cd Length: 260  Bit Score: 68.52  E-value: 6.76e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLrEDRQVRVLLFRSGVKGvFCAGADLKEreQMSEAEVGVFvQRLRGLMNDIA---- 76
Cdd:PRK07659  21 LNRPEALNALDEPMLKELLQALKEV-AESSAHIVVLRGNGRG-FSAGGDIKM--MLSSNDESKF-DGVMNTISEIVvtly 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  77 ------------SSAVMGL-----------IETTR--------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAH 125
Cdd:PRK07659  96 tmpkltisaihgPAAGLGLsialtadyviaDISAKlamnfigiGLIPDGGGHFFLQKRVGENKAKQIIWEGKKLSATEAL 175
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 126 VLGLVNhAVAQNEEGDAAYQRARALAQEILpQAPIAVRLGKVAIDRGTEVDIasgMAIEGMCYAQNIPTRDRLEGMAAFR 205
Cdd:PRK07659 176 DLGLID-EVIGGDFQTAAKQKISEWLQKPL-KAMIETKQIYCELNRSQLEQV---LQLEKRAQYAMRQTADHKEGIRAFL 250
                        250
                 ....*....|
gi 985801722 206 EKRTPKFVGK 215
Cdd:PRK07659 251 EKRLPVFKGE 260
fadB PRK11730
fatty acid oxidation complex subunit alpha FadB;
2-143 4.78e-13

fatty acid oxidation complex subunit alpha FadB;


Pssm-ID: 183293 [Multi-domain]  Cd Length: 715  Bit Score: 67.19  E-value: 4.78e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGvKGVFCAGADLKERE---QMSEAEVGVFVQRLRGLMNDI--- 75
Cdd:PRK11730  23 DAPGSVNKLDRATLASLGEALDALEAQSDLKGLLLTSA-KDAFIVGADITEFLslfAAPEEELSQWLHFANSIFNRLedl 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ----------------------------ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVL 127
Cdd:PRK11730 102 pvptvaaingyalgggcecvlatdyrvaSPDARIGLPETKLGIMPGFGGTVRLPRLIGADNALEWIAAGKDVRAEDALKV 181
                        170
                 ....*....|....*.
gi 985801722 128 GLVNHAVAQNEEGDAA 143
Cdd:PRK11730 182 GAVDAVVAPEKLQEAA 197
PRK08258 PRK08258
enoyl-CoA hydratase family protein;
1-214 8.65e-13

enoyl-CoA hydratase family protein;


Pssm-ID: 181329  Cd Length: 277  Bit Score: 65.37  E-value: 8.65e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALgnVFVS--ELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKE----REQMSEAEV-------GVFVQR 67
Cdd:PRK08258  32 LNRPERKNPL--TFESyaELRDLFRELVYADDVKAVVLT-GAGGNFCSGGDVHEiigpLTKMDMPELlaftrmtGDLVKA 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  68 LRGLMNDIASS---------AVMGL-----IET---------TRGLLPGA--GGTQRLPRCLGVALAKELIFTGRRLSGT 122
Cdd:PRK08258 109 MRACPQPIIAAvdgvcagagAILAMasdlrLGTpsaktaflfTRVGLAGAdmGACALLPRIIGQGRASELLYTGRSMSAE 188
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 123 EAHVLGLVNHAVaqneEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRgtEVDIASGMAIEGMCYAQNI--PTRDRLEG 200
Cdd:PRK08258 189 EGERWGFFNRLV----EPEELLAEAQALARRLAAGPTFAHGMTKTMLHQ--EWDMGLEEAIEAEAQAQAIcmQTEDFRRA 262
                        250
                 ....*....|....
gi 985801722 201 MAAFREKRTPKFVG 214
Cdd:PRK08258 263 YEAFVAKRKPVFEG 276
PRK08259 PRK08259
crotonase/enoyl-CoA hydratase family protein;
1-158 1.08e-12

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236205  Cd Length: 254  Bit Score: 64.92  E-value: 1.08e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKE--REQMSEAEVG----VFVQRLR----- 69
Cdd:PRK08259  18 LNRPEVRNAVDGPTAAALADAFRAFDADDAASVAVL-WGAGGTFCAGADLKAvgTGRGNRLHPSgdgpMGPSRMRlskpv 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -----------GL-------MNDIASSAVMG---------LIEttrgllpgaGGTQRLPRCLGVALAKELIFTGRRLSGT 122
Cdd:PRK08259  97 iaavsgyavagGLelalwcdLRVAEEDAVFGvfcrrwgvpLID---------GGTVRLPRLIGHSRAMDLILTGRPVDAD 167
                        170       180       190
                 ....*....|....*....|....*....|....*...
gi 985801722 123 EAHVLGLVNHAVAQNEegdaAYQRARALAQEI--LPQA 158
Cdd:PRK08259 168 EALAIGLANRVVPKGQ----ARAAAEELAAELaaFPQT 201
PRK07327 PRK07327
enoyl-CoA hydratase/isomerase family protein;
1-212 9.49e-12

enoyl-CoA hydratase/isomerase family protein;


Pssm-ID: 235991  Cd Length: 268  Bit Score: 62.35  E-value: 9.49e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQMseaeVGVFVQRLRgLMNDiASSAV 80
Cdd:PRK07327  27 LNGPGALNAADARMHRELADIWRDVDRDPDVRVVLIR-GEGKAFSAGGDLALVEEM----ADDFEVRAR-VWRE-ARDLV 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  81 MGLIE-------TTRGLLPGAG--------------------GTQRL------------PRCLGVALAKELIFTGRRLSG 121
Cdd:PRK07327 100 YNVINcdkpivsAIHGPAVGAGlvaalladisiaakdariidGHTRLgvaagdhaaivwPLLCGMAKAKYYLLLCEPVSG 179
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 122 TEAHVLGLVNHAVAQNEEGDAAYQRARALAQeilpQAPIAVRLGKVAID---RGTEVDIASGMAIEGMCYAqnipTRDRL 198
Cdd:PRK07327 180 EEAERIGLVSLAVDDDELLPKALEVAERLAA----GSQTAIRWTKYALNnwlRMAGPTFDTSLALEFMGFS----GPDVR 251
                        250
                 ....*....|....
gi 985801722 199 EGMAAFREKRTPKF 212
Cdd:PRK07327 252 EGLASLREKRAPDF 265
PRK06143 PRK06143
enoyl-CoA hydratase; Provisional
8-208 3.29e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 180423  Cd Length: 256  Bit Score: 60.82  E-value: 3.29e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   8 NALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDI------------ 75
Cdd:PRK06143  29 NILGTPVILALTQALRWLAADPDVRVLVLRGAGEKAFIGGADIKEMATLDQASAEAFISRLRDLCDAVrhfpvpviarip 108
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 -------------------ASSAVMGLIETTRGlLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVnHAVAQ 136
Cdd:PRK06143 109 gwclggglelaaacdlriaAHDAQFGMPEVRVG-IPSVIHAALLPRLIGWARTRWLLLTGETIDAAQALAWGLV-DRVVP 186
                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985801722 137 NEEGDAAYQRaraLAQEILPQAPIAVRLGKVAI----DRGTEVDIASGMAIEGMCYAQNIPTRDrlegMAAFREKR 208
Cdd:PRK06143 187 LAELDAAVER---LAASLAGCGPQALRQQKRLLreweDMPLDVAIDDSVAEFGAAFLTGEPQRH----MAAFLNRK 255
PRK08290 PRK08290
enoyl-CoA hydratase; Provisional
1-211 3.49e-11

enoyl-CoA hydratase; Provisional


Pssm-ID: 236220 [Multi-domain]  Cd Length: 288  Bit Score: 61.13  E-value: 3.49e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADLKEREQMSEAEVGvFVQRLRGLMNDIASSAV 80
Cdd:PRK08290  19 LNRPEARNAQNRQMLYELDAAFRRAEADDAVRVIVLAGAGKH-FSAGHDLGSGTPGRDRDPG-PDQHPTLWWDGATKPGV 96
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  81 MGLI--------ETTR--------------------GLL------------------P----GAGGTQRL--PRCLGVAL 108
Cdd:PRK08290  97 EQRYarewevylGMCRrwrdlpkptiaqvqgaciagGLMlawvcdlivasddaffsdPvvrmGIPGVEYFahPWELGPRK 176
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 109 AKELIFTGRRLSGTEAHVLGLVNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVD-----IASGMAI 183
Cdd:PRK08290 177 AKELLFTGDRLTADEAHRLGMVNRVVPRDE----LEAETLELARRIAAMPPFGLRLTKRAVNQTLDAQgfraaLDAVFDL 252
                        250       260       270
                 ....*....|....*....|....*....|....
gi 985801722 184 EGMCYAQN------IPTRDRLEGMAAFREKRTPK 211
Cdd:PRK08290 253 HQLGHAHNaevggdRLGGADARGMADARKAAAAK 286
ECH_2 pfam16113
Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: ...
2-134 6.41e-11

Enoyl-CoA hydratase/isomerase; This family contains a diverse set of enzymes including: enoyl-CoA hydratase, napthoate synthase, carnitate racemase, 3-hydroxybutyryl-CoA dehydratase and dodecanoyl-CoA delta-isomerase. This family differs from pfam00378 in the structure of it's C-terminus.


Pssm-ID: 465024 [Multi-domain]  Cd Length: 331  Bit Score: 60.56  E-value: 6.41e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722    2 NRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRS-GVKGvFCAGADLKE-REQMSE---AEVGVFVQRLRGLMNDIA 76
Cdd:pfam16113   7 NRPKALNALNLEMVRALLAALKAWEDDPAVKLVVLKGaGERA-FCAGGDVRAlYEAAKAgggEAGRDFFREEYRLNYLIA 85
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   77 SSA----------VMG------------------LI---ETTRGLLPGAGGTQRLPRC---LGVALAkeliFTGRRLSGT 122
Cdd:pfam16113  86 TYPkpyvalmdgiVMGggvglsvhgsfrvvtertRFampETAIGLFPDVGGSYFLSRLpgeLGLYLA----LTGARLNGA 161
                         170
                  ....*....|..
gi 985801722  123 EAHVLGLVNHAV 134
Cdd:pfam16113 162 DALAAGLATHYV 173
PRK05981 PRK05981
enoyl-CoA hydratase/isomerase;
1-215 6.50e-11

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235661  Cd Length: 266  Bit Score: 60.13  E-value: 6.50e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDR-QVRVLLFRSGVKGvFCAGADLKER-EQMSEAEVGV------------FVQ 66
Cdd:PRK05981  19 LDHPEVMNAVSIDMLGGLAEALDAIEDGKaEVRCLVLTGAGRG-FCTGANLQGRgSGGRESDSGGdagaaletayhpFLR 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  67 RLRGLMNDIASS------------AVMG-LIETTR-----------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGT 122
Cdd:PRK05981  98 RLRNLPCPIVTAvngpaagvgmsfALMGdLILCARsayflqafrriGLVPDGGSTWLLPRLVGKARAMELSLLGEKLPAE 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 123 EAHVLGLVNHAVAQNEEGDAAYQRARALAqeilpQAPiAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIP--TRDRLEG 200
Cdd:PRK05981 178 TALQWGLVNRVVDDAELMAEAMKLAHELA-----NGP-TVALGLIRKLYWDSPENDFEEQLNLEREAQRIAgkTEDFKEG 251
                        250
                 ....*....|....*
gi 985801722 201 MAAFREKRTPKFVGK 215
Cdd:PRK05981 252 VGAFLQKRPAQFKGR 266
PRK05869 PRK05869
enoyl-CoA hydratase; Validated
1-170 1.22e-10

enoyl-CoA hydratase; Validated


Pssm-ID: 235632 [Multi-domain]  Cd Length: 222  Bit Score: 58.70  E-value: 1.22e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSArNALGNVFVSELLETLAQL-REDRQVRVLLFrsGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDIAS-- 77
Cdd:PRK05869  23 LSRPPT-NALTRQVYREIVAAANELgRRDDVAAVILY--GGHEIFSAGDDMPELRTLSAQEADTAARVRQQAVDAVAAip 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  78 -----------------------------SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK05869 100 kptvaaitgyalgagltlalaadwrvsgdNVKFGATEILAGLAPSGDGMARLTRAAGPSRAKELVFSGRFFDAEEALALG 179
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 985801722 129 LVNHAVAQneegDAAYQRARALAQEILPQAPIAVRLGKVAID 170
Cdd:PRK05869 180 LIDEMVAP----DDVYDAAAAWARRFLDGPPHALAAAKAGIS 217
PRK06072 PRK06072
enoyl-CoA hydratase; Provisional
1-214 1.25e-10

enoyl-CoA hydratase; Provisional


Pssm-ID: 168377 [Multi-domain]  Cd Length: 248  Bit Score: 59.02  E-value: 1.25e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLKE-REQMSEAEVGVFVQRLRGL-------- 71
Cdd:PRK06072  15 MSRPDKLNALNLEMRNEFISKLKQINADPKIRVVIV-TGEGRAFCVGADLSEfAPDFAIDLRETFYPIIREIrfsdkiyi 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  72 --MNDIASSAVMGLIETTR-----------------GLLPGAGGTQRLPRcLGVALAKELIFTGRRLSGTEAHVLGLVnh 132
Cdd:PRK06072  94 saINGVTAGACIGIALSTDfkfasrdvkfvtafqrlGLASDTGVAYFLLK-LTGQRFYEILVLGGEFTAEEAERWGLL-- 170
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 133 avaqnEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTEVDIASGMAIEGMCYAQNIPTRDRLEGMAAFREKRTPKF 212
Cdd:PRK06072 171 -----KISEDPLSDAEEMANRISNGPFQSYIAAKRMINLVLYNDLEEFLEYESAIQGYLGKTEDFKEGISSFKEKREPKF 245

                 ..
gi 985801722 213 VG 214
Cdd:PRK06072 246 KG 247
PRK07396 PRK07396
dihydroxynaphthoic acid synthetase; Validated
1-212 3.40e-10

dihydroxynaphthoic acid synthetase; Validated


Pssm-ID: 180958 [Multi-domain]  Cd Length: 273  Bit Score: 57.98  E-value: 3.40e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQ---MSEAEVGVF----VQRL----- 68
Cdd:PRK07396  28 INRPEVRNAFRPKTVKEMIDAFADARDDDNIGVIILTGAGDKAFCSGGDQKVRGYggyVDDDGVPRLnvldLQRLirtcp 107
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  69 -------RG----------LMND--IAS-SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PRK07396 108 kpviamvAGyaiggghvlhLVCDltIAAdNAIFGQTGPKVGSFDGGYGASYLARIVGQKKAREIWFLCRQYDAQEALDMG 187
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAVAQNEEGDAAYQRARalaqEILPQAPIAVRLGKVAIDrgTEVDIASGMA-IEG---MCYAQnipTRDRLEGMAAF 204
Cdd:PRK07396 188 LVNTVVPLADLEKETVRWCR----EMLQNSPMALRCLKAALN--ADCDGQAGLQeLAGnatMLFYM---TEEAQEGRNAF 258

                 ....*...
gi 985801722 205 REKRTPKF 212
Cdd:PRK07396 259 NEKRQPDF 266
PRK07110 PRK07110
polyketide biosynthesis enoyl-CoA hydratase; Validated
1-152 1.41e-09

polyketide biosynthesis enoyl-CoA hydratase; Validated


Pssm-ID: 235936  Cd Length: 249  Bit Score: 56.13  E-value: 1.41e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQMSEAEVGVFVQRLRGLMND------ 74
Cdd:PRK07110  20 MQDRVNKNAFSDELCDQLHEAFDTIAQDPRYKVVILT-GYPNYFATGGTQEGLLSLQTGKGTFTEANLYSLALNcpipvi 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  75 -------IASSAVMGL-----------IETTR----GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNH 132
Cdd:PRK07110  99 aamqghaIGGGLVLGLyadivvlsresVYTANfmkyGFTPGMGATAILPEKLGLALGQEMLLTARYYRGAELKKRGVPFP 178
                        170       180
                 ....*....|....*....|
gi 985801722 133 AVAQNEEGDAAYQRARALAQ 152
Cdd:PRK07110 179 VLPRAEVLEKALELARSLAE 198
PRK07854 PRK07854
enoyl-CoA hydratase; Provisional
1-215 5.68e-09

enoyl-CoA hydratase; Provisional


Pssm-ID: 236115 [Multi-domain]  Cd Length: 243  Bit Score: 54.26  E-value: 5.68e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLrEDRQVRVLLFRsGVKGVFCAGADLKEREQMSEaevgvFVQRLRGLMNDIaSSAV 80
Cdd:PRK07854  15 LQRPERRNALNAELCEELREAVRKA-VDESARAIVLT-GQGTVFCAGADLSGDVYADD-----FPDALIEMLHAI-DAAP 86
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  81 MGLIETTRGLLPGAgGTQ---------------------------------RLPRCLGVALAKELIFTGRRLSGTEAHVL 127
Cdd:PRK07854  87 VPVIAAINGPAIGA-GLQlamacdlrvvapeayfqfpvakygialdnwtirRLSSLVGGGRARAMLLGAEKLTAEQALAT 165
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 128 GLVnhavaqNEEGDAAyqRARALAQEILPQAPIAVRLGKVAI-DRGTEVDIASG-MAIEGMCYAqnipTRDRLEGMAAFR 205
Cdd:PRK07854 166 GMA------NRIGTLA--DAQAWAAEIAGLAPLALQHAKRVLnDDGAIEEAWPAhKELFDKAWA----SQDAIEAQVARI 233
                        250
                 ....*....|
gi 985801722 206 EKRTPKFVGK 215
Cdd:PRK07854 234 EKRPPKFQGA 243
PLN02921 PLN02921
naphthoate synthase
1-212 1.29e-08

naphthoate synthase


Pssm-ID: 178509 [Multi-domain]  Cd Length: 327  Bit Score: 54.02  E-value: 1.29e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGVFCAGADLKEREQ-----------MSEAEVGVFVQRL- 68
Cdd:PLN02921  82 INRPERRNAFRPRTVKELQRAFNDARDDSSVGVIILTGKGTKAFCSGGDQAVRGKdgyvgpddagrLNVLDLQIQIRRLp 161
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  69 -------RG----------LMNDI---ASSAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLG 128
Cdd:PLN02921 162 kpviamvAGyavggghilhMVCDLtiaADNAVFGQTGPKVGSFDAGYGSSIMARLVGQKKAREMWFLARFYTASEALKMG 241
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 129 LVNHAV--AQNEEGDAAYQRaralaqEILPQAPIAVRLGKVAIDRGTevDIASGmaIEGMcyAQNIP-----TRDRLEGM 201
Cdd:PLN02921 242 LVNTVVplDELEGETVKWCR------EILRNSPTAIRVLKSALNAAD--DGHAG--LQEL--GGNATllfygSEEGNEGR 309
                        250
                 ....*....|.
gi 985801722 202 AAFREKRTPKF 212
Cdd:PLN02921 310 TAYLEGRAPDF 320
MenB COG0447
1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1, ...
1-212 1.34e-08

1,4-Dihydroxy-2-naphthoyl-CoA synthase [Coenzyme transport and metabolism]; 1,4-Dihydroxy-2-naphthoyl-CoA synthase is part of the Pathway/BioSystem: Menaquinone biosynthesis


Pssm-ID: 440216  Cd Length: 281  Bit Score: 53.67  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLF-----RSGVKGVFCAGADLKEREQ---MSEAEVGVF----VQRL 68
Cdd:COG0447   33 INRPEVRNAFRPETVDELYDALDHAREDPDVGVVLLtgngpSKDGGWAFCSGGDQRVRGRggyVYEDGVGRLnileVQRL 112
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  69 RGLMND------------------------IAS-SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTE 123
Cdd:COG0447  113 IRFMPKpviamvagwaiggghvlhvvcdltIASeNARFGQTGPDVGSFDAGYGSAYLARQVGQKKAREIWFLCRQYSAQE 192
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 124 AHVLGLVNHAVAQNEEGDAAYQRARalaqEILPQAPIAVRLGKVAIDRGTEvdiasGMAieG----------MCYAqnip 193
Cdd:COG0447  193 ALEMGLVNKVVPHAELEEEAVEWAR----EILEKSPTAIRMLKAAFNADDD-----GLA--GqqefageatrLAYM---- 257
                        250
                 ....*....|....*....
gi 985801722 194 TRDRLEGMAAFREKRTPKF 212
Cdd:COG0447  258 TDEAQEGRDAFLEKRKPDF 276
PRK07938 PRK07938
enoyl-CoA hydratase family protein;
8-169 4.31e-08

enoyl-CoA hydratase family protein;


Pssm-ID: 181174  Cd Length: 249  Bit Score: 51.90  E-value: 4.31e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   8 NALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADLKEREQMSEAEVGVFVQR-------------------- 67
Cdd:PRK07938  23 NALPSAGWFALADAITAAGADPDTRVVVLRAEGRG-FNAGVDIKELQATPGFTALIDANRgcfaafravyecavpviaav 101
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  68 ----------LRGLMNDIASS--AVMGLIETTRGLLPGAGGTQRLprcLGVALAKELIFTGRRLSGTEAHVLGLVnHAVA 135
Cdd:PRK07938 102 hgfclgggigLVGNADVIVASddATFGLPEVDRGALGAATHLQRL---VPQHLMRALFFTAATITAAELHHFGSV-EEVV 177
                        170       180       190
                 ....*....|....*....|....*....|....
gi 985801722 136 QNEEGDAAyqrARALAQEILPQAPIAVRLGKVAI 169
Cdd:PRK07938 178 PRDQLDEA---ALEVARKIAAKDTRVIRAAKEAL 208
PRK05617 PRK05617
3-hydroxyisobutyryl-CoA hydrolase; Provisional
2-138 1.10e-07

3-hydroxyisobutyryl-CoA hydrolase; Provisional


Pssm-ID: 235533 [Multi-domain]  Cd Length: 342  Bit Score: 50.97  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   2 NRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRS-GVKGvFCAGADLKE-----REQMSEAEVGVFVQRLR------ 69
Cdd:PRK05617  19 NRPKALNALSLEMIRAIDAALDAWEDDDAVAAVVIEGaGERG-FCAGGDIRAlyeaaRAGDPLAADRFFREEYRlnalia 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  70 -------GLMNDIassaVMG-------------LIETTR--------GLLPGAGGTQRLPRCLGvALAKELIFTGRRLSG 121
Cdd:PRK05617  98 rypkpyiALMDGI----VMGggvgisahgshriVTERTKmampetgiGFFPDVGGTYFLSRAPG-ALGTYLALTGARISA 172
                        170
                 ....*....|....*..
gi 985801722 122 TEAHVLGLVNHAVAQNE 138
Cdd:PRK05617 173 ADALYAGLADHFVPSAD 189
PRK08321 PRK08321
1,4-dihydroxy-2-naphthoyl-CoA synthase;
96-212 1.80e-06

1,4-dihydroxy-2-naphthoyl-CoA synthase;


Pssm-ID: 181386  Cd Length: 302  Bit Score: 47.33  E-value: 1.80e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  96 GTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHAVAQNEEGDAAYQRARalaqEILPQAPIAVRLGKVA---IDRG 172
Cdd:PRK08321 184 GSAYLARQVGQKFAREIFFLGRTYSAEEAHDMGAVNAVVPHAELETEALEWAR----EINGKSPTAMRMLKYAfnlTDDG 259
                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 985801722 173 -TEVDIASGMAIEgMCYAqnipTRDRLEGMAAFREKRTPKF 212
Cdd:PRK08321 260 lVGQQLFAGEATR-LAYM----TDEAQEGRDAFLEKRDPDW 295
PRK07827 PRK07827
enoyl-CoA hydratase family protein;
1-214 2.87e-06

enoyl-CoA hydratase family protein;


Pssm-ID: 236109 [Multi-domain]  Cd Length: 260  Bit Score: 46.60  E-value: 2.87e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVR-VLLFRSGvkGVFCAGADLKE--REQMSEAEVGVFVQR-LRGLMNDIA 76
Cdd:PRK07827  21 LDSPHNRNALSARLVAQLHDGLRAAAADPAVRaVVLTHTG--GTFCAGADLSEagGGGGDPYDAAVARAReMTALLRAIV 98
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  77 SSAV--------------MGLI-----------------ETTRGLLPGAGGTQRLPRCLGVALAKELIfTGRRLSGTEAH 125
Cdd:PRK07827  99 ELPKpviaaidghvraggFGLVgacdivvagpestfaltEARIGVAPAIISLTLLPRLSPRAAARYYL-TGEKFGAAEAA 177
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 126 VLGLVNHAVAQNEEGDAAYQRARALAQeilPQAPIAV-RLGKVAIDRGTEVDiASGMAIEGmcyAQNIPTRDRLEGMAAF 204
Cdd:PRK07827 178 RIGLVTAAADDVDAAVAALLADLRRGS---PQGLAESkALTTAAVLAGFDRD-AEELTEES---ARLFVSDEAREGMTAF 250
                        250
                 ....*....|
gi 985801722 205 REKRTPKFVG 214
Cdd:PRK07827 251 LQKRPPRWAL 260
PRK07260 PRK07260
enoyl-CoA hydratase; Provisional
1-130 4.24e-06

enoyl-CoA hydratase; Provisional


Pssm-ID: 180910 [Multi-domain]  Cd Length: 255  Bit Score: 46.27  E-value: 4.24e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKgVFCAGADLKEREQMSEAEVGVFVQRLRGLMNDI----- 75
Cdd:PRK07260  17 LNRPEVSNGFNIPMCQEILEALRLAEEDPSVRFLLINANGK-VFSVGGDLVEMKRAVDEDDVQSLVKIAELVNEIsfaik 95
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ---------ASSAVMG-----------LIETTR----------GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAH 125
Cdd:PRK07260  96 qlpkpvimcVDGAVAGaaanmavaadfCIASTKtkfiqafvgvGLAPDAGGLFLLTRAIGLNRATHLAMTGEALTAEKAL 175

                 ....*
gi 985801722 126 VLGLV 130
Cdd:PRK07260 176 EYGFV 180
PRK05674 PRK05674
gamma-carboxygeranoyl-CoA hydratase; Validated
1-210 9.17e-06

gamma-carboxygeranoyl-CoA hydratase; Validated


Pssm-ID: 168168  Cd Length: 265  Bit Score: 45.18  E-value: 9.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLKEREQMSE----------AEVGVFVQRLRG 70
Cdd:PRK05674  21 LSRADKNNAFNAQMIRELILALDQVQSDASLRFLLLR-GRGRHFSAGADLAWMQQSADldyntnlddaRELAELMYNLYR 99
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  71 L------------------------MNDIASSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK05674 100 LkiptlavvqgaafggalglisccdMAIGADDAQFCLSEVRIGLAP-AVISPFVVKAIGERAARRYALTAERFDGRRARE 178
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 127 LGLVNHAVAQNEegdaAYQRARALAQEILPQAPIAVRLGKvaiDRGTEVDiASGMAIEGMCYAQNIPTRDRL-----EGM 201
Cdd:PRK05674 179 LGLLAESYPAAE----LEAQVEAWIANLLLNSPQALRASK---DLLREVG-DGELSPALRRYCENAIARIRVsaegqEGL 250

                 ....*....
gi 985801722 202 AAFREKRTP 210
Cdd:PRK05674 251 RAFLEKRTP 259
PRK05864 PRK05864
enoyl-CoA hydratase; Provisional
1-213 1.76e-05

enoyl-CoA hydratase; Provisional


Pssm-ID: 168278 [Multi-domain]  Cd Length: 276  Bit Score: 44.44  E-value: 1.76e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADLKE-----------------REQMSEAEVGV 63
Cdd:PRK05864  25 LNRPERMNSMAFDVMVPLKEALAEVSYDNSVRVVVLTGAGRG-FSSGADHKSagvvphvegltrptyalRSMELLDDVIL 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  64 FVQRLR------------------GLMNDI---ASSAVMGLIETTRGLLPGAGG-TQRLPRCLGVALAKELIFTGRRLSG 121
Cdd:PRK05864 104 ALRRLHqpviaavngpaiggglclALAADIrvaSSSAYFRAAGINNGLTASELGlSYLLPRAIGSSRAFEIMLTGRDVDA 183
                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722 122 TEAHVLGLVNHAVAQNEEGDAAYQRARALAQEILPQAPIAVRLGKVAIDRGTevdIASGMAIEGMcyAQ---NIPTRDRL 198
Cdd:PRK05864 184 EEAERIGLVSRQVPDEQLLDTCYAIAARMAGFSRPGIELTKRTLWSGLDAAS---LEAHMQAEGL--GQlfvRLLTANFE 258
                        250
                 ....*....|....*
gi 985801722 199 EGMAAFREKRTPKFV 213
Cdd:PRK05864 259 EAVAARAEKRPPVFT 273
PLN03214 PLN03214
probable enoyl-CoA hydratase/isomerase; Provisional
18-152 2.71e-05

probable enoyl-CoA hydratase/isomerase; Provisional


Pssm-ID: 215635  Cd Length: 278  Bit Score: 43.72  E-value: 2.71e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  18 LLETLAQLREDRQVRVLLFRSGV-KGVFCAGADLKEREQMSEAEV---------GVFVQRL-----------RG------ 70
Cdd:PLN03214  43 LDDALTALENDPTVRGVVFASGLrRDVFTAGNDIAELYAPKTSAAryaefwltqTTFLVRLlrsrlatvcaiRGacpagg 122
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  71 ----LMND---IASSAVMGLIETTRGL-LPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVNHAVAQNEEGDA 142
Cdd:PLN03214 123 cavsLCCDyrlQTTEGTMGLNEVALGIpVPKFWARLFMGRVIDRKVAESLLLRGRLVRPAEAKQLGLIDEVVPAAALMEA 202
                        170
                 ....*....|
gi 985801722 143 AYQRARALAQ 152
Cdd:PLN03214 203 AASAMERALK 212
PRK07112 PRK07112
enoyl-CoA hydratase/isomerase;
3-138 4.22e-05

enoyl-CoA hydratase/isomerase;


Pssm-ID: 235938  Cd Length: 255  Bit Score: 43.13  E-value: 4.22e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   3 RPSARNALGNVFVSELLETLAQLREDRQVRVLlfrSGVKGVFCAGADLKE--------REQMSEAEV----------GVF 64
Cdd:PRK07112  21 RPEAQNTINDRLIAECMDVLDRCEHAATIVVL---EGLPEVFCFGADFSAiaekpdagRADLIDAEPlydlwhrlatGPY 97
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  65 V--QRLRGLMN----------DIA---SSAVMGLIETTRGLLPgAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGL 129
Cdd:PRK07112  98 VtiAHVRGKVNaggigfvaasDIViadETAPFSLSELLFGLIP-ACVLPFLIRRIGTQKAHYMTLMTQPVTAQQAFSWGL 176

                 ....*....
gi 985801722 130 VNHAVAQNE 138
Cdd:PRK07112 177 VDAYGANSD 185
PLN02874 PLN02874
3-hydroxyisobutyryl-CoA hydrolase-like protein
1-51 4.84e-05

3-hydroxyisobutyryl-CoA hydrolase-like protein


Pssm-ID: 178462 [Multi-domain]  Cd Length: 379  Bit Score: 43.25  E-value: 4.84e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGADLK 51
Cdd:PLN02874  26 LNRPRQLNVISLSVVSLLAEFLEQWEKDDSVELIIIK-GAGRAFSAGGDLK 75
PLN02988 PLN02988
3-hydroxyisobutyryl-CoA hydrolase
1-134 5.23e-05

3-hydroxyisobutyryl-CoA hydrolase


Pssm-ID: 178568 [Multi-domain]  Cd Length: 381  Bit Score: 43.17  E-value: 5.23e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRsGVKGVFCAGAD----LKEREQ--------------------- 55
Cdd:PLN02988  24 LNRPKQLNALSFHMISRLLQLFLAFEEDPSVKLVILK-GHGRAFCAGGDvaavVRDIEQgnwrlganffsdeymlnyvma 102
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  56 -MSEAEVGVFVQ---------RLRGLMNDIASSAVMGLIETTRGLLPGAGGTQRLPRCLGVaLAKELIFTGRRLSGTEAH 125
Cdd:PLN02988 103 tYSKAQVSILNGivmgggagvSVHGRFRIATENTVFAMPETALGLFPDVGASYFLSRLPGF-FGEYVGLTGARLDGAEML 181

                 ....*....
gi 985801722 126 VLGLVNHAV 134
Cdd:PLN02988 182 ACGLATHFV 190
PRK08788 PRK08788
enoyl-CoA hydratase; Validated
78-143 1.62e-04

enoyl-CoA hydratase; Validated


Pssm-ID: 236338  Cd Length: 287  Bit Score: 41.44  E-value: 1.62e-04
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985801722  78 SAVMGLIETTRGLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHVLGLVnHAVAQNEEGDAA 143
Cdd:PRK08788 151 GAKMGFPEILFNLFPGMGAYSFLARRVGPKLAEELILSGKLYTAEELHDMGLV-DVLVEDGQGEAA 215
PRK08272 PRK08272
crotonase/enoyl-CoA hydratase family protein;
1-154 1.86e-04

crotonase/enoyl-CoA hydratase family protein;


Pssm-ID: 236213  Cd Length: 302  Bit Score: 41.57  E-value: 1.86e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFRSGVKGvFCAGADLKE-REQMSEAEVG----VFVQRLRGLMNDI 75
Cdd:PRK08272  25 LNRPEKGNAITADTPLELRAAVERADLDPGVHVILVSGAGKG-FCAGYDLSAyAEGSSSGGGGgaypGKRQAVNHLPDDP 103
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  76 ASSAV--MGLIETTRGLL-------PG---------AGGTQRLPRC------------------------------LGVA 107
Cdd:PRK08272 104 WDPMIdyQMMSRFVRGFMslwhahkPTvakvhgycvAGGTDIALHCdqviaaddakigypptrvwgvpatgmwayrLGPQ 183
                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*..
gi 985801722 108 LAKELIFTGRRLSGTEAHVLGLVNHAVaqneEGDAAYQRARALAQEI 154
Cdd:PRK08272 184 RAKRLLFTGDCITGAQAAEWGLAVEAV----PPEELDERTERLVERI 226
PRK05870 PRK05870
enoyl-CoA hydratase; Provisional
1-151 5.48e-03

enoyl-CoA hydratase; Provisional


Pssm-ID: 180298  Cd Length: 249  Bit Score: 37.01  E-value: 5.48e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722   1 MNRPSARNALGNVFVSELLETLAQLREDRQVRVLLFrSGVKGVFCAGADLkerEQMSEAEVGVFVQRLRGL--------- 71
Cdd:PRK05870  18 VNDPDRRNAVTAEMSAQLRAAVAAAEADPDVHALVV-TGAGKAFCAGADL---TALGAAPGRPAEDGLRRIydgflavas 93
                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985801722  72 -----------------MN-------DIASSAVMGLIETTR-GLLPGAGGTQRLPRCLGVALAKELIFTGRRLSGTEAHV 126
Cdd:PRK05870  94 cplptiaavngaavgagLNlalaadvRIAGPKALFDARFQKlGLHPGGGATWMLQRAVGPQVARAALLFGMRFDAEAAVR 173
                        170       180
                 ....*....|....*....|....*
gi 985801722 127 LGLVNHAVaqNEEGDAAYQRARALA 151
Cdd:PRK05870 174 HGLALMVA--DDPVAAALELAAGPA 196
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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