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Conserved domains on  [gi|985481964|ref|NP_001306228|]
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ankyrin repeat and SOCS box protein 8 isoform b [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-127 1.67e-37

Ankyrin repeat [Signal transduction mechanisms];


:

Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666   99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNgNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 184-226 4.89e-20

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


:

Pssm-ID: 239697  Cd Length: 43  Bit Score: 79.88  E-value: 4.89e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLL 226
Cdd:cd03727    1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLLLL 43
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-127 1.67e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666   99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNgNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
Ank_2 pfam12796
Ankyrin repeats (3 copies);
29-120 1.37e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   29 LHYAAE-KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESgASVNALDYNNdTPLSWAAMKGNLESVS 107
Cdd:pfam12796   1 LHLAAKnGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 985481964  108 ILLDYGAEVRVIN 120
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 8-120 3.62e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 87.80  E-value: 3.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVNALDGYNRTALHYAAE---------------------KDEacVEVLLEYGANPNALDGNRDTPLHWAAF 66
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLEsnkidlkilkllidkgvdinaKNR--VNYLLSYGVPINIKDVYGFTPLHYAVY 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 985481964  67 KNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVIN 120
Cdd:PHA03100 202 NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 184-226 4.89e-20

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 79.88  E-value: 4.89e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLL 226
Cdd:cd03727    1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLLLL 43
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 4-131 2.60e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVE-LLLEKGAEVNALDGYNRTALHYAA--EKDEACVeVLLEygANPNALD---------GnrDTPLHWAAFKNNAE 71
Cdd:cd22192   29 DVQAIKkLLKCPSCDLFQRGALGETALHVAAlyDNLEAAV-VLME--AAPELVNepmtsdlyqG--ETALHIAVVNQNLN 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985481964  72 CVRALLESGASVN--------------ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLV 131
Cdd:cd22192  104 LVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 6-117 7.93e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.01  E-value: 7.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964    6 DCVELLLEKGAEVNALDgynrTALHYAAEKDEACVEVLL--------EYGANPNALDGNRD------TPLHWAAFKNNAE 71
Cdd:TIGR00870  67 ELTELLLNLSCRGAVGD----TLLHAISLEYVDAVEAILlhllaafrKSGPLELANDQYTSeftpgiTALHLAAHRQNYE 142

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   72 CVRALLESGASVNA--------------LDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 117
Cdd:TIGR00870 143 IVKLLLERGASVPAracgdffvksqgvdSFYHGESPLNAAACLGSPSIVALLSEDPADIL 202
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 186-224 1.58e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.39  E-value: 1.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 985481964  186 PGTLKTLARYAVRRSLGlQYLPDAVKGLPLPASLKEYLL 224
Cdd:pfam07525   2 PRSLQHLCRLAIRRALG-KRRLGAIDKLPLPPLLKDYLL 39
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 56-85 4.01e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 985481964    56 NRDTPLHWAAFKNNAECVRALLESGASVNA 85
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 188-225 1.23e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.16  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 985481964   188 TLKTLARYAVRRSLGlqylpdAVKGLPLPASLKEYLLL 225
Cdd:smart00969   2 SLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLY 33
 
Name Accession Description Interval E-value
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-127 1.67e-37

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 132.39  E-value: 1.67e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666   99 DLEIVKLLLEAGADVNARDKDGETPLHLAAYNgNLEIVKLLLEAGADVNAQDNDGNTPLHLAAANGNLEIVKLLLEAGAD 178

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666  179 VNARDNDGETPLHLAAENGHLEIVKLLLEAGADVNAKDNDGKTAL 223
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-134 9.64e-33

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 120.06  E-value: 9.64e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666  132 NLEIVKLLLEAGADVNAQDNDGNTPLHLAAANgNLEIVKLLLEAGADVNARDNDGETPLHLAAENGHLEIVKLLLEAGAD 211

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVALL 134
Cdd:COG0666  212 VNAKDNDGKTALDLAAENGNLEIVKLLLEAGADLNAKDKDGLTALLLAAAAG 263
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-126 2.70e-30

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 113.51  E-value: 2.70e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666   66 DLLVALLLLAAGADINAKDDGGNTLLHAAARNgDLEIVKLLLEAGADVNARDKDGETPLHLAAYNGNLEIVKLLLEAGAD 145

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTP 126
Cdd:COG0666  146 VNAQDNDGNTPLHLAAANGNLEIVKLLLEAGADVNARDNDGETP 189
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
4-127 3.85e-22

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 91.94  E-value: 3.85e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:COG0666  165 NLEIVKLLLEAGADVNARDNDGETPLHLAAENgHLEIVKLLLEAGADVNAKDNDGKTALDLAAENGNLEIVKLLLEAGAD 244

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 985481964  83 VNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666  245 LNAKDKDGLTALLLAAAAGAALIVKLLLLALLLLAAALLDLLTLL 289
Ank_2 pfam12796
Ankyrin repeats (3 copies);
29-120 1.37e-20

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 82.47  E-value: 1.37e-20
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   29 LHYAAE-KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESgASVNALDYNNdTPLSWAAMKGNLESVS 107
Cdd:pfam12796   1 LHLAAKnGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVK 78

                          90
                  ....*....|...
gi 985481964  108 ILLDYGAEVRVIN 120
Cdd:pfam12796  79 LLLEKGADINVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 8-120 3.62e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 87.80  E-value: 3.62e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVNALDGYNRTALHYAAE---------------------KDEacVEVLLEYGANPNALDGNRDTPLHWAAF 66
Cdd:PHA03100 124 VEYLLDNGANVNIKNSDGENLLHLYLEsnkidlkilkllidkgvdinaKNR--VNYLLSYGVPINIKDVYGFTPLHYAVY 201

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 985481964  67 KNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVIN 120
Cdd:PHA03100 202 NNNPEFVKYLLDLGANPNLVNKYGDTPLHIAILNNNKEIFKLLLNNGPSIKTII 255
SOCS_ASB8 cd03727
SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a ...
 184-226 4.89e-20

SOCS (suppressors of cytokine signaling) box of ASB8-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB8 is highly transcribed in skeletal muscle and in lung carcinoma cell lines. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239697  Cd Length: 43  Bit Score: 79.88  E-value: 4.89e-20
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLLLL 226
Cdd:cd03727    1 SAPGTLKALARYAVRRSLGVQYLPEAVKQLPLPRSVKEYLLLL 43
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 4-161 9.12e-20

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 86.86  E-value: 9.12e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYN-RTALHYAAE-KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGA 81
Cdd:PHA02878 146 EAEITKLLLSYGADINMKDRHKgNTALHYATEnKDQRLTELLLSYGANVNIPDKTNNSPLHHAVKHYNKPIVHILLENGA 225

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  82 SVNALDYNNDTPLSWAAmkGNLESVSI-----------------------------------LLDYGAEVRVINLIGQTP 126
Cdd:PHA02878 226 STDARDKCGNTPLHISV--GYCKDYDIlklllehgvdvnaksyilgltalhssikserklklLLEYGADINSLNSYKLTP 303

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 985481964 127 ISRLVallvrglgteKEDSCFELLHRAVGHFELRK 161
Cdd:PHA02878 304 LSSAV----------KQYLCINIGRILISNICLLK 328
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 6-154 2.15e-19

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 86.27  E-value: 2.15e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNALDGYNRTALHYAAEKDEAC-VEVLLEYGANPNALDGNRDTPLHWAAFKNNA-ECVRALLESGASV 83
Cdd:PHA02876 356 DIVITLLELGANVNARDYCDKTPIHYAAVRNNVViINTLLDYGADIEALSQKIGTALHFALCGTNPyMSVKTLIDRGANV 435

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985481964  84 NALDYNNDTPLSWAAMKG-NLESVSILLDYGAEVRVINLIGQTPIsrLVALLVRGL-------GTEKEDScfELLHRAV 154
Cdd:PHA02876 436 NSKNKDLSTPLHYACKKNcKLDVIEMLLDNGADVNAINIQNQYPL--LIALEYHGIvnillhyGAELRDS--RVLHKSL 510
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
8-127 4.16e-19

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 83.46  E-value: 4.16e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNAL 86
Cdd:COG0666   37 LLLLLLALLALALADALGALLLLAAALAgDLLVALLLLAAGADINAKDDGGNTLLHAAARNGDLEIVKLLLEAGADVNAR 116

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 985481964  87 DYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666  117 DKDGETPLHLAAYNGNLEIVKLLLEAGADVNAQDNDGNTPL 157
Ank_2 pfam12796
Ankyrin repeats (3 copies);
4-87 9.06e-19

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 77.85  E-value: 9.06e-19
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964    4 DADCVELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYgANPNALDGNRdTPLHWAAFKNNAECVRALLESGAS 82
Cdd:pfam12796   9 NLELVKLLLENGADANLQDKNGRTALHLAAKNGHLeIVKLLLEH-ADVNLKDNGR-TALHYAARSGHLEIVKLLLEKGAD 86


                  ....*
gi 985481964   83 VNALD 87
Cdd:pfam12796  87 INVKD 91
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 8-132 1.06e-18

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 83.56  E-value: 1.06e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVNALDGYNRTALHYAAEK---DEACVEVLLEYGANPNALDGNRDTPLHWAAFKN---------------- 68
Cdd:PHA03100  89 VKLLLEYGANVNAPDNNGITPLLYAISKksnSYSIVEYLLDNGANVNIKNSDGENLLHLYLESNkidlkilkllidkgvd 168

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 985481964  69 -NAEC-VRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA 132
Cdd:PHA03100 169 iNAKNrVNYLLSYGVPINIKDVYGFTPLHYAVYNNNPEFVKYLLDLGANPNLVNKYGDTPLHIAIL 234
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 6-127 1.10e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 83.86  E-value: 1.10e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVN 84
Cdd:PHA02874 105 DMIKTILDCGIDVNIKDAELKTFLHYAIKKgDLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFFDIIKLLLEKGAYAN 184

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 985481964  85 ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA02874 185 VKDNNGESPLHNAAEYGDYACIKLLIDHGNHIMNKCKNGFTPL 227
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 8-137 3.95e-18

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 82.42  E-value: 3.95e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVNALDGYNRTALHYAAEK--DEACVEVLLEYGANPNALDGNRDTPLHWAA-FKNNAECVRALLESGASVN 84
Cdd:PHA02876 290 VPKLLERGADVNAKNIKGETPLYLMAKNgyDTENIRTLIMLGADVNAADRLYITPLHQAStLDRNKDIVITLLELGANVN 369

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 985481964  85 ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVIN----------LIGQTPISRLVALLVRG 137
Cdd:PHA02876 370 ARDYCDKTPIHYAAVRNNVVIINTLLDYGADIEALSqkigtalhfaLCGTNPYMSVKTLIDRG 432
PHA03095 PHA03095
ankyrin-like protein; Provisional
 4-151 2.39e-16

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 76.99  E-value: 2.39e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALH----YAAEKDEACVEVLLEYGANPNALDGNRDTPLH-WAAFKNNAECVRALLE 78
Cdd:PHA03095  26 TVEEVRRLLAAGADVNFRGEYGKTPLHlylhYSSEKVKDIVRLLLEAGADVNAPERCGFTPLHlYLYNATTLDVIKLLIK 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  79 SGASVNALDYNNDTPLSwAAMKG---NLESVSILLDYGAEVRVINLIGQTPIS----------RLVALLVRGLG--TEKE 143
Cdd:PHA03095 106 AGADVNAKDKVGRTPLH-VYLSGfniNPKVIRLLLRKGADVNALDLYGMTPLAvllksrnanvELLRLLIDAGAdvYAVD 184


                 ....*...
gi 985481964 144 DSCFELLH 151
Cdd:PHA03095 185 DRFRSLLH 192
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 9-153 1.28e-15

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 75.10  E-value: 1.28e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   9 ELLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRA------------ 75
Cdd:PHA02876 162 EMLLEGGADVNAKDIYCITPIHYAAERGNAkMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAiidnrsninknd 241

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  76 -----------------LLESGASVNALDYNNDTPLSWAAMKGNLES-VSILLDYGAEVRVINLIGQTPI---------- 127
Cdd:PHA02876 242 lsllkairnedletsllLYDAGFSVNSIDDCKNTPLHHASQAPSLSRlVPKLLERGADVNAKNIKGETPLylmakngydt 321

                        170       180
                 ....*....|....*....|....*..
gi 985481964 128 SRLVALLVRGLGTEKEDSCFEL-LHRA 153
Cdd:PHA02876 322 ENIRTLIMLGADVNAADRLYITpLHQA 348
PHA03095 PHA03095
ankyrin-like protein; Provisional
 4-132 1.75e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 74.68  E-value: 1.75e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAE---KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAEC--VRALLE 78
Cdd:PHA03095 166 NVELLRLLIDAGADVYAVDDRFRSLLHHHLQsfkPRARIVRELIRAGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLI 245

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 985481964  79 SGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLVA 132
Cdd:PHA03095 246 AGISINARNRYGQTPLHYAAVFNNPRACRRLIALGADINAVSSDGNTPLSLMVR 299
PHA03095 PHA03095
ankyrin-like protein; Provisional
 4-127 7.07e-15

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 72.75  E-value: 7.07e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVEV---LLEYGANPNALDGNRDTPLHWAA--FKNNAECVRALLE 78
Cdd:PHA03095 131 NPKVIRLLLRKGADVNALDLYGMTPLAVLLKSRNANVELlrlLIDAGADVYAVDDRFRSLLHHHLqsFKPRARIVRELIR 210

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985481964  79 SGASVNALDYNNDTPLSWAAMKGNLES--VSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA03095 211 AGCDPAATDMLGNTPLHSMATGSSCKRslVLPLLIAGISINARNRYGQTPL 261
PHA03100 PHA03100
ankyrin repeat protein; Provisional
 24-127 1.37e-12

ankyrin repeat protein; Provisional


Pssm-ID: 222984 [Multi-domain]  Cd Length: 422  Bit Score: 65.84  E-value: 1.37e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  24 YNRTALHYAAEKD--EACVEVLLEYGANPNALDGNRDTPLHWAA-----FKNNAECVRALLESGASVNALDYNNDTPLSW 96
Cdd:PHA03100  33 KKPVLPLYLAKEArnIDVVKILLDNGADINSSTKNNSTPLHYLSnikynLTDVKEIVKLLLEYGANVNAPDNNGITPLLY 112

                         90       100       110
                 ....*....|....*....|....*....|...
gi 985481964  97 AAMK--GNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA03100 113 AISKksNSYSIVEYLLDNGANVNIKNSDGENLL 145
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 6-127 1.85e-12

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 65.76  E-value: 1.85e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNALDGYNRTALHYAAE-KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAecVRALLESGASVN 84
Cdd:PHA02874 171 DIIKLLLEKGAYANVKDNNGESPLHNAAEyGDYACIKLLIDHGNHIMNKCKNGFTPLHNAIIHNRS--AIELLINNASIN 248

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 985481964  85 ALDYNNDTPLSWAAM-KGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA02874 249 DQDIDGSTPLHHAINpPCDIDIIDILLYHKADISIKDNKGENPI 292
PHA03095 PHA03095
ankyrin-like protein; Provisional
 3-110 2.03e-11

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 62.73  E-value: 2.03e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   3 SDADCVELLLEKGAEVNALDGYNRTALHYAAeKDEAC----VEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLE 78
Cdd:PHA03095 200 PRARIVRELIRAGCDPAATDMLGNTPLHSMA-TGSSCkrslVLPLLIAGISINARNRYGQTPLHYAAVFNNPRACRRLIA 278

                         90       100       110
                 ....*....|....*....|....*....|..
gi 985481964  79 SGASVNALDYNNDTPLSWAAMKGNLESVSILL 110
Cdd:PHA03095 279 LGADINAVSSDGNTPLSLMVRNNNGRAVRAAL 310
Ank_2 pfam12796
Ankyrin repeats (3 copies);
61-127 2.08e-11

Ankyrin repeats (3 copies);


Pssm-ID: 463710 [Multi-domain]  Cd Length: 91  Bit Score: 58.20  E-value: 2.08e-11
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 985481964   61 LHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYgAEVRVINLiGQTPI 127
Cdd:pfam12796   1 LHLAAKNGNLELVKLLLENGADANLQDKNGRTALHLAAKNGHLEIVKLLLEH-ADVNLKDN-GRTAL 65
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 30-115 5.48e-11

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 61.45  E-value: 5.48e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  30 HYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSIL 109
Cdd:PTZ00322  88 QLAASGDAVGARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLL 167


                 ....*.
gi 985481964 110 LDYGAE 115
Cdd:PTZ00322 168 SRHSQC 173
Ank_4 pfam13637
Ankyrin repeats (many copies);
57-110 1.61e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 54.97  E-value: 1.61e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 985481964   57 RDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILL 110
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
TRPV5-6 cd22192
Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and ...
 4-131 2.60e-10

Transient Receptor Potential channel, Vanilloid subfamily (TRPV), types 5 and 6; TRPV5 and TRPV6 (TRPV5/6) are two homologous members within the vanilloid subfamily of the transient receptor potential (TRP) family. TRPV5 and TRPV6 show only 30-40% homology with other members of the TRP family and have unique properties that differentiates them from other TRP channels. They mediate calcium uptake in epithelia and their expression is dramatically increased in numerous types of cancer. The structure of TRPV5/6 shows the typical topology features of all TRP family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6, which is predicted to form the Ca2+ pore, and large intracellular N- and C-terminal domains. The N-terminal domain of TRPV5/6 contains three ankyrin repeats. This structural element is present in several proteins and plays a role in protein-protein interactions. The N- and C-terminal tails of TRPV5/6 each contain an internal PDZ motif which can function as part of a molecular scaffold via interaction with PDZ-domain containing proteins. A major difference between the properties of TRPV5 and TRPV6 is in their tissue distribution: TRPV5 is predominantly expressed in the distal convoluted tubules (DCT) and connecting tubules (CNT) of the kidney, with limited expression in extrarenal tissues. In contrast, TRPV6 has a broader expression pattern such as expression in the intestine, kidney, placenta, epididymis, exocrine tissues, and a few other tissues.


Pssm-ID: 411976 [Multi-domain]  Cd Length: 609  Bit Score: 59.64  E-value: 2.60e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVE-LLLEKGAEVNALDGYNRTALHYAA--EKDEACVeVLLEygANPNALD---------GnrDTPLHWAAFKNNAE 71
Cdd:cd22192   29 DVQAIKkLLKCPSCDLFQRGALGETALHVAAlyDNLEAAV-VLME--AAPELVNepmtsdlyqG--ETALHIAVVNQNLN 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985481964  72 CVRALLESGASVN--------------ALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLV 131
Cdd:cd22192  104 LVRELIARGADVVspratgtffrpgpkNLIYYGEHPLSFAACVGNEEIVRLLIEHGADIRAQDSLGNTVLHILV 177
Ank_4 pfam13637
Ankyrin repeats (many copies);
25-77 4.60e-10

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 53.43  E-value: 4.60e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 985481964   25 NRTALHYAAEK-DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALL 77
Cdd:pfam13637   1 ELTALHAAAASgHLELLRLLLEKGADINAVDGNGETALHFAASNGNVEVLKLLL 54
PHA02946 PHA02946
ankyin-like protein; Provisional
 36-116 1.25e-09

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 57.37  E-value: 1.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  36 DEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGN--LESVSILLDYG 113
Cdd:PHA02946  51 DERFVEELLHRGYSPNETDDDGNYPLHIASKINNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDevIERINLLVQYG 130


                 ...
gi 985481964 114 AEV 116
Cdd:PHA02946 131 AKI 133
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 4-152 1.71e-09

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 56.92  E-value: 1.71e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNAL---DGynRTALHYAAE-KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLES 79
Cdd:PHA02875  80 DVKAVEELLDLGKFADDVfykDG--MTPLHLATIlKKLDIMKLLIARGADPDIPNTDKFSPLHLAVMMGDIKGIELLIDH 157

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 985481964  80 GASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEvrvINLIGQTPIsrlVALLVRGLGTEKEDSCFELLHR 152
Cdd:PHA02875 158 KACLDIEDCCGCTPLIIAMAKGDIAICKMLLDSGAN---IDYFGKNGC---VAALCYAIENNKIDIVRLFIKR 224
SOCS_ASB_like cd03716
SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB ...
 184-225 6.83e-09

SOCS (suppressors of cytokine signaling) box of ASB (ankyrin repeat and SOCS box) and SSB (SPRY domain-containing SOCS box proteins) protein families. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence of a variable number of repeats. SSB proteins contain a central SPRY domain and a C-terminal SOCS. Recently, it has been shown that all four SSB proteins interact with the MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), and that SSB-1, SSB-2, and SSB-4 interact with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain.


Pssm-ID: 239686  Cd Length: 42  Bit Score: 50.19  E-value: 6.83e-09
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|..
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQyLPDAVKGLPLPASLKEYLLL 225
Cdd:cd03716    1 STPRSLQHLCRLAIRRCLGRR-RLELIKKLPLPPRLKDYLLY 41
ANKYR COG0666
Ankyrin repeat [Signal transduction mechanisms];
9-127 1.10e-08

Ankyrin repeat [Signal transduction mechanisms];


Pssm-ID: 440430 [Multi-domain]  Cd Length: 289  Bit Score: 54.19  E-value: 1.10e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   9 ELLLEKGAEVNALDGYNRTALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDY 88
Cdd:COG0666    6 LLLLLLLAALLLLLLLALLLLAAALLLLLLLLLLLLLALLALALADALGALLLLAAALAGDLLVALLLLAAGADINAKDD 85

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 985481964  89 NNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:COG0666   86 GGNTLLHAAARNGDLEIVKLLLEAGADVNARDKDGETPL 124
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 4-105 1.14e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 54.52  E-value: 1.14e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:PTZ00322  94 DAVGARILLTGGADPNCRDYDGRTPLHIACANGHvQVVRVLLEFGADPTLLDKDGKTPLELAEENGFREVVQLLSRHSQC 173

                         90       100
                 ....*....|....*....|...
gi 985481964  83 VNALDYNNdTPLSWAAMKGNLES 105
Cdd:PTZ00322 174 HFELGANA-KPDSFTGKPPSLED 195
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-127 1.34e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 54.20  E-value: 1.34e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEKDE-ACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGAS 82
Cdd:PHA02874 136 DLESIKMLFEYGADVNIEDDNGCYPIHIAIKHNFfDIIKLLLEKGAYANVKDNNGESPLHNAAEYGDYACIKLLIDHGNH 215

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*
gi 985481964  83 VNALDYNNDTPLSWAAMKGnlESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA02874 216 IMNKCKNGFTPLHNAIIHN--RSAIELLINNASINDQDIDGSTPL 258
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 1-121 2.77e-08

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 53.72  E-value: 2.77e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   1 MVSDADCVELLLEKGAEVNALDGYNRTALHYAAEKD-EACVEVLLEYGANPNALDGNRDTPLhW---------------- 63
Cdd:PLN03192 534 STGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGyEDCVLVLLKHACNVHIRDANGNTAL-Wnaisakhhkifrilyh 612

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 985481964  64 ----------------AAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINL 121
Cdd:PLN03192 613 fasisdphaagdllctAAKRNDLTAMKELLKQGLNVDSEDHQGATALQVAMAEDHVDMVRLLIMNGADVDKANT 686
PHA02874 PHA02874
ankyrin repeat protein; Provisional
 4-127 2.92e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165205 [Multi-domain]  Cd Length: 434  Bit Score: 53.43  E-value: 2.92e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNR----TALHYAAEKdeaCVEVLLEYGANPNAL---DGNRDTplhwaafknnaecVRAL 76
Cdd:PHA02874  47 DAKIVELFIKHGADINHINTKIPhpllTAIKIGAHD---IIKLLIDNGVDTSILpipCIEKDM-------------IKTI 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 985481964  77 LESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA02874 111 LDCGIDVNIKDAELKTFLHYAIKKGDLESIKMLFEYGADVNIEDDNGCYPI 161
SOCS cd03587
SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region ...
 186-225 3.07e-08

SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins with a SOCS box), and WSBs (WD40 repeat-containing proteins with a SOCS box), as well as, other miscellaneous proteins. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239641  Cd Length: 41  Bit Score: 48.24  E-value: 3.07e-08
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 985481964 186 PGTLKTLARYAVRRSLGLQyLPDAVKGLPLPASLKEYLLL 225
Cdd:cd03587    2 PRSLQHLCRLAIRRCLGKR-RLDLIDKLPLPPRLKDYLLY 40
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 2-61 3.85e-08

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 52.96  E-value: 3.85e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 985481964   2 VSDADCVELLLEKGAEVNALDG-YNRTALHYAAeKDEACVEVLLEYGANPNALDGNRDTPL 61
Cdd:PHA02878 245 CKDYDILKLLLEHGVDVNAKSYiLGLTALHSSI-KSERKLKLLLEYGADINSLNSYKLTPL 304
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 1-84 3.95e-08

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 52.69  E-value: 3.95e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   1 MVSDADCVELLLEKGAEVNALDGYNRTALHYA-AEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNA-ECVRALLE 78
Cdd:PHA02875 144 MMGDIKGIELLIDHKACLDIEDCCGCTPLIIAmAKGDIAICKMLLDSGANIDYFGKNGCVAALCYAIENNKiDIVRLFIK 223


                 ....*.
gi 985481964  79 SGASVN 84
Cdd:PHA02875 224 RGADCN 229
PTZ00322 PTZ00322
6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional
 73-127 5.52e-08

6-phosphofructo-2-kinase/fructose-2,6-biphosphatase; Provisional


Pssm-ID: 140343 [Multi-domain]  Cd Length: 664  Bit Score: 52.59  E-value: 5.52e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*
gi 985481964  73 VRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PTZ00322  98 ARILLTGGADPNCRDYDGRTPLHIACANGHVQVVRVLLEFGADPTLLDKDGKTPL 152
trp TIGR00870
transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ ...
 6-117 7.93e-08

transient-receptor-potential calcium channel protein; The Transient Receptor Potential Ca2+ Channel (TRP-CC) Family (TC. 1.A.4)The TRP-CC family has also been called the store-operated calcium channel (SOC) family. The prototypical members include the Drosophila retinal proteinsTRP and TRPL (Montell and Rubin, 1989; Hardie and Minke, 1993). SOC members of the family mediate the entry of extracellular Ca2+ into cells in responseto depletion of intracellular Ca2+ stores (Clapham, 1996) and agonist stimulated production of inositol-1,4,5 trisphosphate (IP3). One member of the TRP-CCfamily, mammalian Htrp3, has been shown to form a tight complex with the IP3 receptor (TC #1.A.3.2.1). This interaction is apparently required for IP3 tostimulate Ca2+ release via Htrp3. The vanilloid receptor subtype 1 (VR1), which is the receptor for capsaicin (the ?hot? ingredient in chili peppers) and servesas a heat-activated ion channel in the pain pathway (Caterina et al., 1997), is also a member of this family. The stretch-inhibitable non-selective cation channel(SIC) is identical to the vanilloid receptor throughout all of its first 700 residues, but it exhibits a different sequence in its last 100 residues. VR1 and SICtransport monovalent cations as well as Ca2+. VR1 is about 10x more permeable to Ca2+ than to monovalent ions. Ca2+ overload probably causes cell deathafter chronic exposure to capsaicin. (McCleskey and Gold, 1999). [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273311 [Multi-domain]  Cd Length: 743  Bit Score: 52.01  E-value: 7.93e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964    6 DCVELLLEKGAEVNALDgynrTALHYAAEKDEACVEVLL--------EYGANPNALDGNRD------TPLHWAAFKNNAE 71
Cdd:TIGR00870  67 ELTELLLNLSCRGAVGD----TLLHAISLEYVDAVEAILlhllaafrKSGPLELANDQYTSeftpgiTALHLAAHRQNYE 142

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   72 CVRALLESGASVNA--------------LDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 117
Cdd:TIGR00870 143 IVKLLLERGASVPAracgdffvksqgvdSFYHGESPLNAAACLGSPSIVALLSEDPADIL 202
SOCS_box pfam07525
SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more ...
 186-224 1.58e-07

SOCS box; The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases.


Pssm-ID: 462192  Cd Length: 39  Bit Score: 46.39  E-value: 1.58e-07
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 985481964  186 PGTLKTLARYAVRRSLGlQYLPDAVKGLPLPASLKEYLL 224
Cdd:pfam07525   2 PRSLQHLCRLAIRRALG-KRRLGAIDKLPLPPLLKDYLL 39
PHA02876 PHA02876
ankyrin repeat protein; Provisional
 34-154 1.65e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165207 [Multi-domain]  Cd Length: 682  Bit Score: 51.22  E-value: 1.65e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  34 EKDEACV-EVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKGNLESVSILLDY 112
Cdd:PHA02876 154 QQDELLIaEMLLEGGADVNAKDIYCITPIHYAAERGNAKMVNLLLSYGADVNIIALDDLSVLECAVDSKNIDTIKAIIDN 233

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 985481964 113 GAEVR-----VINLIGQTPISRLVALLVRGLGTEKEDSCFEL-LHRAV 154
Cdd:PHA02876 234 RSNINkndlsLLKAIRNEDLETSLLLYDAGFSVNSIDDCKNTpLHHAS 281
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 8-127 4.92e-07

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 48.66  E-value: 4.92e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   8 VELLLEKGAEVN-ALDGYNRTALH----YAAEKDEACVEVLLEYGANPNALDGNRDTPLH--WAAFKNNAECVRALLESG 80
Cdd:PHA02859  69 LKFLIENGADVNfKTRDNNLSALHhylsFNKNVEPEILKILIDSGSSITEEDEDGKNLLHmyMCNFNVRINVIKLLIDSG 148

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 985481964  81 ASVNALDYNNDTPL-SWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:PHA02859 149 VSFLNKDFDNNNILySYILFHSDKKIFDFLTSLGIDINETNKSGYNCY 196
Ank_5 pfam13857
Ankyrin repeats (many copies);
43-94 5.45e-07

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 45.42  E-value: 5.45e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 985481964   43 LLEYG-ANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPL 94
Cdd:pfam13857   1 LLEHGpIDLNRLDGEGYTPLHVAAKYGALEIVRVLLAYGVDLNLKDEEGLTAL 53
TRPV cd21882
Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily ...
 26-131 8.80e-07

Transient Receptor Potential channel, Vanilloid subfamily (TRPV); The vanilloid TRP subfamily (TRPV), named after the vanilloid receptor 1 (TRPV1), consists of six members: four thermo-sensing channels (TRPV1, TRPV2, TRPV3, and TRPV4) and two Ca2+ selective channels (TRPV5 and TRPV6). The calcium-selective channels TRPV5 and TRPV6 can be heterotetramers and are important for general Ca2+ homeostasis. All four channels within the TRPV1-4 group show temperature-invoked currents when expressed in heterologous cell systems, ranging from activation at ~25C for TRPV4 to ~52C for TRPV2. The structure of TRPV shows the typical topology features of all Transient Receptor Potential (TRP) ion channel family members, such as six transmembrane regions, a short hydrophobic stretch between transmembrane segments 5 and 6 and large intracellular N- and C-terminal domains. The TRP family consists of membrane proteins that function as ion channels that communicate between the cell and its environment, by a vast array of physical or chemical stimuli, including radiation (in the form of temperature, infrared ,or light) and pressure (osmotic or mechanical). TRP channels are formed by a tetrameric complex of channel subunits. Based on sequence identity, the mammalian TRP channel family is classified into six subfamilies, with significant sequence similarity within the transmembrane domains, but very low similarity in their N- and C-terminal cytoplasmic regions. The six subfamilies are named based on their first member: TRPC (canonical), TRPV (vanilloid), TRPM (melastatin), TRPA (ankyrin), TRPML (mucolipin), and TRPP (polycystic).


Pssm-ID: 411975 [Multi-domain]  Cd Length: 600  Bit Score: 49.11  E-value: 8.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  26 RTALHYAAEKDE----ACVEVLLEYG---------ANPNALDG--NRDTPLHWAAFKNNAECVRALLESGASVNA----- 85
Cdd:cd21882   27 KTCLHKAALNLNdgvnEAIMLLLEAApdsgnpkelVNAPCTDEfyQGQTALHIAIENRNLNLVRLLVENGADVSAratgr 106

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 985481964  86 --------LDYNNDTPLSWAAMKGNLESVSILLDYGAEVRVINL---IGQTPISRLV 131
Cdd:cd21882  107 ffrkspgnLFYFGELPLSLAACTNQEEIVRLLLENGAQPAALEAqdsLGNTVLHALV 163
PHA03095 PHA03095
ankyrin-like protein; Provisional
 11-87 1.02e-06

ankyrin-like protein; Provisional


Pssm-ID: 222980 [Multi-domain]  Cd Length: 471  Bit Score: 48.48  E-value: 1.02e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 985481964  11 LLEKGAEVNALDGYNRTALHYAA--EKDEACVEvLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALD 87
Cdd:PHA03095 243 LLIAGISINARNRYGQTPLHYAAvfNNPRACRR-LIALGADINAVSSDGNTPLSLMVRNNNGRAVRAALAKNPSAETVA 320
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 40-127 2.23e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 47.29  E-value: 2.23e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  40 VEVLLEYGANPNA----LDGNRDTPLHWAAFKNNAECVRALLESGASVNAL-DYNNDTPLSWAAMKGNLESVSILLDYGA 114
Cdd:PHA02884  49 IDAILKLGADPEApfplSENSKTNPLIYAIDCDNDDAAKLLIRYGADVNRYaEEAKITPLYISVLHGCLKCLEILLSYGA 128

                         90
                 ....*....|...
gi 985481964 115 EVRVINLIGQTPI 127
Cdd:PHA02884 129 DINIQTNDMVTPI 141
PHA02741 PHA02741
hypothetical protein; Provisional
 6-117 2.74e-06

hypothetical protein; Provisional


Pssm-ID: 165108 [Multi-domain]  Cd Length: 169  Bit Score: 46.19  E-value: 2.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLekgaevNALDGYNRTALHYAAEKDEA-----CVEVLLEYGANPNALDG-NRDTPLHWAAFKNNAECVRALL-E 78
Cdd:PHA02741  47 DCHAAAL------NATDDAGQMCIHIAAEKHEAqlaaeIIDHLIELGADINAQEMlEGDTALHLAAHRRDHDLAEWLCcQ 120

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 985481964  79 SGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVR 117
Cdd:PHA02741 121 PGIDLHFCNADNKSPFELAIDNEDVAMMQILREIVATSR 159
PHA02798 PHA02798
ankyrin-like protein; Provisional
 6-120 2.82e-06

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 47.52  E-value: 2.82e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNALDGYNRTAL--------HYAAEKDeaCVEVLLEYGANPNALDGNRDTPLHWA---AFKNNAECVR 74
Cdd:PHA02798  52 DIVKLFINLGANVNGLDNEYSTPLctilsnikDYKHMLD--IVKILIENGADINKKNSDGETPLYCLlsnGYINNLEILL 129

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 985481964  75 ALLESGASVNALDYNNDTPLSWAAMKGN---LESVSILLDYGAEVRVIN 120
Cdd:PHA02798 130 FMIENGADTTLLDKDGFTMLQVYLQSNHhidIEIIKLLLEKGVDINTHN 178
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 56-85 4.01e-06

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 42.19  E-value: 4.01e-06
                           10        20        30
                   ....*....|....*....|....*....|
gi 985481964    56 NRDTPLHWAAFKNNAECVRALLESGASVNA 85
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADINA 30
PHA02875 PHA02875
ankyrin repeat protein; Provisional
 35-127 7.76e-06

ankyrin repeat protein; Provisional


Pssm-ID: 165206 [Multi-domain]  Cd Length: 413  Bit Score: 46.14  E-value: 7.76e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  35 KDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESGASVNALDYNN-DTPLSWAAMKGNLESVSILLDYG 113
Cdd:PHA02875  46 RDSEAIKLLMKHGAIPDVKYPDIESELHDAVEEGDVKAVEELLDLGKFADDVFYKDgMTPLHLATILKKLDIMKLLIARG 125

                         90
                 ....*....|....
gi 985481964 114 AEVRVINLIGQTPI 127
Cdd:PHA02875 126 ADPDIPNTDKFSPL 139
PLN03192 PLN03192
Voltage-dependent potassium channel; Provisional
 2-99 8.73e-06

Voltage-dependent potassium channel; Provisional


Pssm-ID: 215625 [Multi-domain]  Cd Length: 823  Bit Score: 46.01  E-value: 8.73e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   2 VSDADCVELLLEKGAE-VNALDGYNrtALHYAAEKDEACVEVLLEYGANPNALDGNRDTPLHWAAFKNNAECVRALLESG 80
Cdd:PLN03192 504 LHDLNVGDLLGDNGGEhDDPNMASN--LLTVASTGNAALLEELLKAKLDPDIGDSKGRTPLHIAASKGYEDCVLVLLKHA 581

                         90
                 ....*....|....*....
gi 985481964  81 ASVNALDYNNDTPLsWAAM 99
Cdd:PLN03192 582 CNVHIRDANGNTAL-WNAI 599
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 56-87 1.17e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 41.12  E-value: 1.17e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 985481964   56 NRDTPLHWAAFK-NNAECVRALLESGASVNALD 87
Cdd:pfam00023   1 DGNTPLHLAAGRrGNLEIVKLLLSKGADVNARD 33
Ank_4 pfam13637
Ankyrin repeats (many copies);
6-44 1.33e-05

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 41.49  E-value: 1.33e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 985481964    6 DCVELLLEKGAEVNALDGYNRTALHYAAEK-DEACVEVLL 44
Cdd:pfam13637  15 ELLRLLLEKGADINAVDGNGETALHFAASNgNVEVLKLLL 54
SOCS_SSB1_4 cd03718
SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box ...
 185-224 1.85e-05

SOCS (suppressors of cytokine signaling) box of SSB1 and SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 and SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF) and also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239688  Cd Length: 42  Bit Score: 40.75  E-value: 1.85e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 985481964 185 APGTLKTLARYAVRRSLGLQYLPDaVKGLPLPASLKEYLL 224
Cdd:cd03718    2 EPLPLMDLCRRRVRVALGRDRLEE-IEQLPLPPSLKNYLL 40
Ank_5 pfam13857
Ankyrin repeats (many copies);
10-64 2.10e-05

Ankyrin repeats (many copies);


Pssm-ID: 433530 [Multi-domain]  Cd Length: 56  Bit Score: 40.79  E-value: 2.10e-05
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 985481964   10 LLLEKGAEVNALDGYNRTALHYAAEKDEA-CVEVLLEYGANPNALDGNRDTPLHWA 64
Cdd:pfam13857   1 LLEHGPIDLNRLDGEGYTPLHVAAKYGALeIVRVLLAYGVDLNLKDEEGLTALDLA 56
PHA02878 PHA02878
ankyrin repeat protein; Provisional
 6-155 2.20e-05

ankyrin repeat protein; Provisional


Pssm-ID: 222939 [Multi-domain]  Cd Length: 477  Bit Score: 44.87  E-value: 2.20e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNALDGYNRTALHYA--AEKDEACVEVLLEYGANP-------------------------NALDGNRD 58
Cdd:PHA02878  51 DVVKSLLTRGHNVNQPDHRDLTPLHIIckEPNKLGMKEMIRSINKCSvfytlvaikdafnnrnveifkiiltNRYKNIQT 130

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  59 TPLHWAAFKN-----NAECVRALLESGASVNALDYNND-TPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPISRLV- 131
Cdd:PHA02878 131 IDLVYIDKKSkddiiEAEITKLLLSYGADINMKDRHKGnTALHYATENKDQRLTELLLSYGANVNIPDKTNNSPLHHAVk 210

                        170       180       190
                 ....*....|....*....|....*....|...
gi 985481964 132 --------ALLVRGLGTEKEDSCFEL-LHRAVG 155
Cdd:PHA02878 211 hynkpivhILLENGASTDARDKCGNTpLHISVG 243
PHA02798 PHA02798
ankyrin-like protein; Provisional
 40-125 3.25e-05

ankyrin-like protein; Provisional


Pssm-ID: 222931 [Multi-domain]  Cd Length: 489  Bit Score: 44.06  E-value: 3.25e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  40 VEVLLEYGANPNALDGNRDTPL-----HWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMKG---NLESVSILLD 111
Cdd:PHA02798  54 VKLFINLGANVNGLDNEYSTPLctilsNIKDYKHMLDIVKILIENGADINKKNSDGETPLYCLLSNGyinNLEILLFMIE 133

                         90
                 ....*....|....
gi 985481964 112 YGAEVRVINLIGQT 125
Cdd:PHA02798 134 NGADTTLLDKDGFT 147
Ank pfam00023
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 24-54 5.99e-05

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities. Repeats 13-24 are especially active, with known sites of interaction for the Na/K ATPase, Cl/HCO(3) anion exchanger, voltage-gated sodium channel, clathrin heavy chain and L1 family cell adhesion molecules. The ANK repeats are found to form a contiguous spiral stack such that ion transporters like the anion exchanger associate in a large central cavity formed by the ANK repeat spiral, while clathrin and cell adhesion molecules associate with specific regions outside this cavity.


Pssm-ID: 459634 [Multi-domain]  Cd Length: 34  Bit Score: 39.19  E-value: 5.99e-05
                          10        20        30
                  ....*....|....*....|....*....|...
gi 985481964   24 YNRTALHYAAEK--DEACVEVLLEYGANPNALD 54
Cdd:pfam00023   1 DGNTPLHLAAGRrgNLEIVKLLLSKGADVNARD 33
SOCS_ASB15 cd03731
SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a ...
 186-227 9.90e-05

SOCS (suppressors of cytokine signaling) box of ASB15-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Human ASB15 is expressed predominantly in skeletal muscle and participates in the regulation of protein turnover and muscle cell development by stimulating protein synthesis and regulating differentiation of muscle cells. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239701  Cd Length: 56  Bit Score: 39.04  E-value: 9.90e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 985481964 186 PGTLKTLARYAVRRSLGLQYL--PDAVKGLPLPASLKEYLLLLE 227
Cdd:cd03731    3 PRPLKHLCRLKIRKLMGLQKLqqPSSMKKLPLPPALKRYILYKE 46
PHA02736 PHA02736
Viral ankyrin protein; Provisional
 4-118 1.18e-04

Viral ankyrin protein; Provisional


Pssm-ID: 165103 [Multi-domain]  Cd Length: 154  Bit Score: 41.02  E-value: 1.18e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNA----LDGYNRTA---LHYAAEKDEA----CVEVLLEYGANPNALDG-NRDTPLHWAAFKNNAE 71
Cdd:PHA02736  27 NGGVTDLLAFKNAISDEnrylVLEYNRHGkqcVHIVSNPDKAdpqeKLKLLMEWGADINGKERvFGNTPLHIAVYTQNYE 106

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 985481964  72 CVRALL-ESGASVNALDYNNDTPLSWAAMKGNLESVSILLDYGAEVRV 118
Cdd:PHA02736 107 LATWLCnQPGVNMEILNYAFKTPYYVACERHDAKMMNILRAKGAQCKV 154
SOCS_box smart00969
The SOCS box acts as a bridge between specific substrate- binding domains and more generic ...
 188-225 1.23e-04

The SOCS box acts as a bridge between specific substrate- binding domains and more generic proteins that comprise a large family of E3 ubiquitin protein ligases;


Pssm-ID: 198037  Cd Length: 34  Bit Score: 38.16  E-value: 1.23e-04
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 985481964   188 TLKTLARYAVRRSLGlqylpdAVKGLPLPASLKEYLLL 225
Cdd:smart00969   2 SLQHLCRLAIRRSLG------GIDKLPLPPRLKDYLLY 33
PHA02859 PHA02859
ankyrin repeat protein; Provisional
 18-94 1.89e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165195 [Multi-domain]  Cd Length: 209  Bit Score: 40.96  E-value: 1.89e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  18 VNALDGYNRTALHYAAEKDEACVEV---LLEYGANPN-ALDGNRDTPLHWAAFKN---NAECVRALLESGASVNALDYNN 90
Cdd:PHA02859  44 VNDCNDLYETPIFSCLEKDKVNVEIlkfLIENGADVNfKTRDNNLSALHHYLSFNknvEPEILKILIDSGSSITEEDEDG 123


                 ....
gi 985481964  91 DTPL 94
Cdd:PHA02859 124 KNLL 127
PHA02884 PHA02884
ankyrin repeat protein; Provisional
 6-99 2.82e-04

ankyrin repeat protein; Provisional


Pssm-ID: 165212 [Multi-domain]  Cd Length: 300  Bit Score: 41.12  E-value: 2.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   6 DCVELLLEKGAEVNA-----LDGYNrTALHYAAEKD-EACVEVLLEYGANPNALDGN-RDTPLHWAAFKNNAECVRALLE 78
Cdd:PHA02884  47 DIIDAILKLGADPEApfplsENSKT-NPLIYAIDCDnDDAAKLLIRYGADVNRYAEEaKITPLYISVLHGCLKCLEILLS 125

                         90       100
                 ....*....|....*....|.
gi 985481964  79 SGASVNALDYNNDTPLSWAAM 99
Cdd:PHA02884 126 YGADINIQTNDMVTPIELALM 146
PHA02791 PHA02791
ankyrin-like protein; Provisional
 22-110 3.98e-04

ankyrin-like protein; Provisional


Pssm-ID: 165154 [Multi-domain]  Cd Length: 284  Bit Score: 40.41  E-value: 3.98e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  22 DGYNRTALHYA-AEKDEACVEVLLEYGANPNALDGnrDTPLHWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK 100
Cdd:PHA02791  27 DVHGHSALYYAiADNNVRLVCTLLNAGALKNLLEN--EFPLHQAATLEDTKIVKILLFSGMDDSQFDDKGNTALYYAVDS 104

                         90
                 ....*....|
gi 985481964 101 GNLESVSILL 110
Cdd:PHA02791 105 GNMQTVKLFV 114
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 24-52 4.75e-04

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 36.41  E-value: 4.75e-04
                           10        20        30
                   ....*....|....*....|....*....|
gi 985481964    24 YNRTALHYAAEK-DEACVEVLLEYGANPNA 52
Cdd:smart00248   1 DGRTPLHLAAENgNLEVVKLLLDKGADINA 30
PHA02946 PHA02946
ankyin-like protein; Provisional
 2-134 7.77e-04

ankyin-like protein; Provisional


Pssm-ID: 165256 [Multi-domain]  Cd Length: 446  Bit Score: 40.04  E-value: 7.77e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   2 VSDADCVELLLEKGAEVNALDGYNRTALHYAAEKDEACVE---VLLEYGAN-PNALDGNRDTPL---------------- 61
Cdd:PHA02946  82 INNNRIVAMLLTHGADPNACDKQHKTPLYYLSGTDDEVIErinLLVQYGAKiNNSVDEEGCGPLlactdpservfkkims 161

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964  62 ------------------HWAAFKNNAECVRALLESGASVNALDYNNDTPLSWAAMK--GNLESVSILLDyGAEVRVINL 121
Cdd:PHA02946 162 igfearivdkfgknhihrHLMSDNPKASTISWMMKLGISPSKPDHDGNTPLHIVCSKtvKNVDIINLLLP-STDVNKQNK 240

                        170
                 ....*....|...
gi 985481964 122 IGQTPISRLVALL 134
Cdd:PHA02946 241 FGDSPLTLLIKTL 253
SOCS_SSB4 cd03743
SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box ...
 186-223 1.21e-03

SOCS (suppressors of cytokine signaling) box of SSB4 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB4 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB4, like SSB2 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239712  Cd Length: 42  Bit Score: 35.70  E-value: 1.21e-03
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 985481964 186 PGTLKTLARYAVRRSLGLQYLPDaVKGLPLPASLKEYL 223
Cdd:cd03743    3 PLPLMDLCRRSARQALGRHRLHH-IQSLPLPQTLKNYL 39
Ank_4 pfam13637
Ankyrin repeats (many copies);
90-127 1.35e-03

Ankyrin repeats (many copies);


Pssm-ID: 372654 [Multi-domain]  Cd Length: 54  Bit Score: 35.71  E-value: 1.35e-03
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 985481964   90 NDTPLSWAAMKGNLESVSILLDYGAEVRVINLIGQTPI 127
Cdd:pfam13637   1 ELTALHAAAASGHLELLRLLLEKGADINAVDGNGETAL 38
SOCS_SSB1 cd03744
SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins) ...
 186-224 1.46e-03

SOCS (suppressors of cytokine signaling) box of SSB1 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB1 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF), both the absence and the presence of HGF and enhances the HGF-MET-induced mitogen-activated protein kinases Erk-transcription factor Elk-1-serum response elements (SRE) pathway. SSB1, like SSB2 and SSB4, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239713  Cd Length: 42  Bit Score: 35.34  E-value: 1.46e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 985481964 186 PGTLKTLARYAVRRSLGLQYLPDaVKGLPLPASLKEYLL 224
Cdd:cd03744    3 PLPLMDLCRRSVRLALGRERLSE-IHTLPLPASLKNYLL 40
ANK smart00248
ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four ...
 89-116 1.49e-03

ankyrin repeats; Ankyrin repeats are about 33 amino acids long and occur in at least four consecutive copies. They are involved in protein-protein interactions. The core of the repeat seems to be an helix-loop-helix structure.


Pssm-ID: 197603 [Multi-domain]  Cd Length: 30  Bit Score: 35.26  E-value: 1.49e-03
                           10        20
                   ....*....|....*....|....*...
gi 985481964    89 NNDTPLSWAAMKGNLESVSILLDYGAEV 116
Cdd:smart00248   1 DGRTPLHLAAENGNLEVVKLLLDKGADI 28
PHA02716 PHA02716
CPXV016; CPX019; EVM010; Provisional
 4-128 1.62e-03

CPXV016; CPX019; EVM010; Provisional


Pssm-ID: 165089 [Multi-domain]  Cd Length: 764  Bit Score: 39.12  E-value: 1.62e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 985481964   4 DADCVELLLEKGAEVNALDGYNRTALHYAAEK---DEACVEVLLEYGANPNALDGNRDTPLHwaafknnaecvrALLESG 80
Cdd:PHA02716 296 DISVVYSFLQPGVKLHYKDSAGRTCLHQYILRhniSTDIIKLLHEYGNDLNEPDNIGNTVLH------------TYLSML 363

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 985481964  81 ASVNALDYNNDTPLswaamkgNLESVSILLDYGAEVRVINLIGQTPIS 128
Cdd:PHA02716 364 SVVNILDPETDNDI-------RLDVIQCLISLGADITAVNCLGYTPLT 404
Ank_3 pfam13606
Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the ...
 59-85 1.92e-03

Ankyrin repeat; Ankyrins are multifunctional adaptors that link specific proteins to the membrane-associated, spectrin- actin cytoskeleton. This repeat-domain is a 'membrane-binding' domain of up to 24 repeated units, and it mediates most of the protein's binding activities.


Pssm-ID: 463933 [Multi-domain]  Cd Length: 30  Bit Score: 34.93  E-value: 1.92e-03
                          10        20
                  ....*....|....*....|....*..
gi 985481964   59 TPLHWAAFKNNAECVRALLESGASVNA 85
Cdd:pfam13606   4 TPLHLAARNGRLEIVKLLLENGADINA 30
SOCS_ASB6 cd03725
SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a ...
 184-224 2.08e-03

SOCS (suppressors of cytokine signaling) box of ASB6-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. ASB6 interacts with the adaptor protein APS and recruits elongin B/C to the insulin receptor signaling complex. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239695  Cd Length: 44  Bit Score: 35.11  E-value: 2.08e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQYLPDAVKGLPLPASLKEYLL 224
Cdd:cd03725    1 SYPPPLKHLCRVFIRLCLRPWPVDVKVKALPLPDRLKWYLL 41
SOCS_ASB4_ASB18 cd03723
SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members ...
 186-225 2.44e-03

SOCS (suppressors of cytokine signaling) box of ASB4 and ASB18 proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. Asb4 was identified as imprinted gene in mice. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239693  Cd Length: 48  Bit Score: 35.11  E-value: 2.44e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 985481964 186 PGTLKTLARYAVRRSLGlQYLPDAVKGLPLPASLKEYLLL 225
Cdd:cd03723    3 PRSLQHLCRCAIRKLLG-SRCHKLVPQLSLPTSLKNYLLL 41
SOCS_ASB1 cd03720
SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a ...
 184-224 3.14e-03

SOCS (suppressors of cytokine signaling) box of ASB1-like proteins. ASB family members have a C-terminal SOCS box and an N-terminal ankyrin-related sequence. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239690  Cd Length: 42  Bit Score: 34.32  E-value: 3.14e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 985481964 184 SAPGTLKTLARYAVRRSLGLQYLpDAVKGLPLPASLKEYLL 224
Cdd:cd03720    1 GNPRSLLSLCRIAVRRALGKQRL-SLICSLPLPDPIKKFLL 40
SOCS_SOCS_like cd03717
SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of ...
 188-224 3.48e-03

SOCS (suppressors of cytokine signaling) box of SOCS-like proteins. The CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. These intracellular proteins regulate the responses of immune cells to cytokines. Identified as negative regulators of the cytokine-JAK-STAT pathway, they seem to play a role in many immunological and pathological processes. The function of the SOCS box is the recruitment of the ubiquitin-transferase system. Related SOCS boxes are also present in Rab40-like proteins and insect proteins of unknown function that also contain a NEUZ (domain in neuralized proteins) domain.


Pssm-ID: 239687  Cd Length: 39  Bit Score: 34.11  E-value: 3.48e-03
                         10        20        30
                 ....*....|....*....|....*....|....*..
gi 985481964 188 TLKTLARYAVRRSLGLqylpDAVKGLPLPASLKEYLL 224
Cdd:cd03717    5 SLQHLCRFVIRQCTRR----DLIDQLPLPRRLKDYLK 37
SOCS_SSB2 cd03719
SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins) ...
 186-224 8.58e-03

SOCS (suppressors of cytokine signaling) box of SSB2 (SPRY domain-containing SOCS box proteins)-like proteins. SSB proteins contain a central SPRY domain and a C-terminal SOCS. SSB2 has been shown to bind to MET, the receptor protein-tyrosine kinase for hepatocyte growth factor (HGF). SSB2, like SSB4 and SSB1, also interacts with prostate apoptosis response protein-4. Both types of interactions are mediated through the SPRY domain. The general function of the SOCS box is the recruitment of the ubiquitin-transferase system. The SOCS box interacts with Elongins B and C, Cullin-5 or Cullin-2, Rbx-1, and E2. Therefore, SOCS-box-containing proteins probably function as E3 ubiquitin ligases and mediate the degradation of proteins associated through their N-terminal regions.


Pssm-ID: 239689  Cd Length: 42  Bit Score: 33.46  E-value: 8.58e-03
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 985481964 186 PGTLKTLARYAVRRSLGLQYLpDAVKGLPLPASLKEYLL 224
Cdd:cd03719    3 PHSLLHLSRLCVRHALGDTRL-GQVSALPLPPAMKRYLL 40
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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