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Conserved domains on  [gi|982742405|ref|NP_001306075|]
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zinc finger protein 64 isoform e [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11473154)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-122 4.68e-05

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.68e-05
                          10        20
                  ....*....|....*....|....*.
gi 982742405   97 DLDRHLRIHTGDKPHKCEFCDKCFSR 122
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-226 1.08e-04

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742405  95 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 164
Cdd:COG5048  302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742405 165 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 226
Cdd:COG5048  382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-122 4.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.68e-05
                          10        20
                  ....*....|....*....|....*.
gi 982742405   97 DLDRHLRIHTGDKPHKCEFCDKCFSR 122
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-226 1.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742405  95 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 164
Cdd:COG5048  302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742405 165 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 226
Cdd:COG5048  382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-233 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 982742405  209 DLKRHMIVHSGEKPFKCEFCDVRCT 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
 
Name Accession Description Interval E-value
zf-H2C2_2 pfam13465
Zinc-finger double domain;
97-122 4.68e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.05  E-value: 4.68e-05
                          10        20
                  ....*....|....*....|....*.
gi 982742405   97 DLDRHLRIHTGDKPHKCEFCDKCFSR 122
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
95-226 1.08e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.08e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742405  95 MKDLDRHLR--IHTG--DKPHKC--EFCDKCFSRKDNLTMHMRCHTSVKPHKCHLCDYAAVDSSSLKK----HLRIHSDE 164
Cdd:COG5048  302 SSPLTRHLRsvNHSGesLKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLLNSSSKFSPLLNNeppqSLQQYKDL 381

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 982742405 165 RPYKCQLCPYASRNS-----SQLTVHLRSHTGDTP--FQCWLCSAKFKISSDLKRHMIVHSGEKPFKCE 226
Cdd:COG5048  382 KNDKKSETLSNSCIRnfkrdSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCS 450
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 163-246 2.43e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 2.43e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 982742405 163 DERPYKCQL--CPYASRNSSQLTVH-LRSHtgdtpfqcwlCSAKFKISSDLKRHMIVHSGEKPFKCEFCDVRCTMKANLK 239
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHmLHGH----------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 982742405 240 SHIRIKH 246
Cdd:COG5189  416 YHRKHSH 422
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
108-162 2.48e-03

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 40.06  E-value: 2.48e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 982742405 108 DKPHKCEFCDKCFSRKDNLTMHMRCHTSVKPHKCHL--CDYAAVDSSSLKKHLRIHS 162
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHH 87
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-233 2.80e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 2.80e-03
                          10        20
                  ....*....|....*....|....*
gi 982742405  209 DLKRHMIVHSGEKPFKCEFCDVRCT 233
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
125-147 5.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.62e-03
                          10        20
                  ....*....|....*....|...
gi 982742405  125 NLTMHMRCHTSVKPHKCHLCDYA 147
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKS 23
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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