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Conserved domains on  [gi|981220777|ref|NP_001306053|]
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zinc finger protein 431 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 4.02e-29

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 4.02e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 981220777    35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLaGVAVSKQDPVTCLEQEKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-563 9.35e-11

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 9.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 231 NSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKC--EECGKAFKQSSTLTTHKIIHTGEKPYRCEecgKAFNRSSHLTTH- 307
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 308 KIIHTGEKPYKCE-ECGKAFNQSSTLSTHKFIHAGEKPYKCeeCDKAFNRFSYLTKhKIIHTGEKSYKCEECGKGFNWSS 386
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTP-QSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 387 TLTKHKRIHTGEKPYKCEvCGKAFNESSNLTTHKMIHTGEKPYKCEECGKAF----NRSPQLTAHKIIHTGEKPYKCEEC 462
Cdd:COG5048  186 LLISSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 463 G--KAFSQSSILTTHKRIHTG-EKPYKCEECGKAFNRSSNLTKHK--IIHTGE--KSYKCEE--CGKAFNQSSTLTKHRK 533
Cdd:COG5048  265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|
gi 981220777 534 IHTRQKPYNCEECDNTFNQSSNLIKQNNSY 563
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKFSPLLNNEPPQS 374
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-214 3.18e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|..
gi 981220777  193 NRHKTRHTGKKPFKCKKCGKSF 214
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 4.02e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 4.02e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 981220777    35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLaGVAVSKQDPVTCLEQEKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 35-74 2.40e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.40e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 981220777   35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFL 74
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 3.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.94e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 981220777  35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFL 74
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-563 9.35e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 9.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 231 NSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKC--EECGKAFKQSSTLTTHKIIHTGEKPYRCEecgKAFNRSSHLTTH- 307
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 308 KIIHTGEKPYKCE-ECGKAFNQSSTLSTHKFIHAGEKPYKCeeCDKAFNRFSYLTKhKIIHTGEKSYKCEECGKGFNWSS 386
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTP-QSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 387 TLTKHKRIHTGEKPYKCEvCGKAFNESSNLTTHKMIHTGEKPYKCEECGKAF----NRSPQLTAHKIIHTGEKPYKCEEC 462
Cdd:COG5048  186 LLISSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 463 G--KAFSQSSILTTHKRIHTG-EKPYKCEECGKAFNRSSNLTKHK--IIHTGE--KSYKCEE--CGKAFNQSSTLTKHRK 533
Cdd:COG5048  265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|
gi 981220777 534 IHTRQKPYNCEECDNTFNQSSNLIKQNNSY 563
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKFSPLLNNEPPQS 374
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-272 2.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.48e-05
                          10        20
                  ....*....|....*....|....*
gi 981220777  248 LTRHKRIHTGEKPFKCEECGKAFKQ 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-214 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|..
gi 981220777  193 NRHKTRHTGKKPFKCKKCGKSF 214
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
35-96 4.02e-29

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 109.60  E-value: 4.02e-29
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 981220777    35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFLaGVAVSKQDPVTCLEQEKEPWN 96
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSL-GFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 35-74 2.40e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 84.06  E-value: 2.40e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 981220777   35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFL 74
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSL 41
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 35-74 3.94e-18

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 77.97  E-value: 3.94e-18
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 981220777  35 LTFRDVAIEFSLEEWECLNPAQQNLYMNVMLENYKNLVFL 74
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
231-563 9.35e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 64.33  E-value: 9.35e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 231 NSYQCEECGKAFKWFSTLTRHKRIHTGEKPFKC--EECGKAFKQSSTLTTHKIIHTGEKPYRCEecgKAFNRSSHLTTH- 307
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNS---KSLPLSNSKASSs 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 308 KIIHTGEKPYKCE-ECGKAFNQSSTLSTHKFIHAGEKPYKCeeCDKAFNRFSYLTKhKIIHTGEKSYKCEECGKGFNWSS 386
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNN--PLPGNNSSSVNTP-QSNSLHPPLPANSLSKDPSSNLS 185

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 387 TLTKHKRIHTGEKPYKCEvCGKAFNESSNLTTHKMIHTGEKPYKCEECGKAF----NRSPQLTAHKIIHTGEKPYKCEEC 462
Cdd:COG5048  186 LLISSNVSTSIPSSSENS-PLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSpkslLSQSPSSLSSSDSSSSASESPRSS 264

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 463 G--KAFSQSSILTTHKRIHTG-EKPYKCEECGKAFNRSSNLTKHK--IIHTGE--KSYKCEE--CGKAFNQSSTLTKHRK 533
Cdd:COG5048  265 LptASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHIL 344

                        330       340       350
                 ....*....|....*....|....*....|
gi 981220777 534 IHTRQKPYNCEECDNTFNQSSNLIKQNNSY 563
Cdd:COG5048  345 LHTSISPAKEKLLNSSSKFSPLLNNEPPQS 374
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
202-554 8.97e-10

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 61.25  E-value: 8.97e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 202 KKPFKCKKCGKSFCMLLHLSQHKRIHIRENSYQC--EECGKAFKWFSTLTRHKRIHTGEKPFkcEECGKAFKQSSTLTTH 279
Cdd:COG5048   31 PRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSD--LNSKSLPLSNSKASSS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 280 KIIHTGEKPYRCE-ECGKAFNRSSHLTTHKIIHTGEKPYKCEE-------------------------CGKAFNQSSTLS 333
Cdd:COG5048  109 SLSSSSSNSNDNNlLSSHSLPPSSRDPQLPDLLSISNLRNNPLpgnnsssvntpqsnslhpplpanslSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 334 THKFIHAGEKPYKCEECDKA------------FNRFSYLTKHKIIHTGEKSYKCE---------------ECGKGFNWSS 386
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSysipssssdqnlENSSSSLPLTTNSQLSPKSLLSQspsslsssdssssasESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 387 TLTKHKRIHTGE-------KPYKCEVCGKAFNESSNLTTHK--MIHTGE--KPYKCEE--CGKAFNRSPQLTAHKIIHTG 453
Cdd:COG5048  269 SSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLrsVNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 454 EKPYKC--EECGKAFSQSSI-----LTTHKRIHTGEKPYKCE--ECGKAFNRSSNLTKHKIIHTGEKS--YKCEECGKAF 522
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSF 428

                        410       420       430
                 ....*....|....*....|....*....|..
gi 981220777 523 NQSSTLTKHRKIHTRQKPYNCEECDNTFNQSS 554
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
315-476 1.10e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.10e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 315 KPYKCEECGKAFNQSSTLSTHKF--IHAGE--KPYKCEE--CDKAFNRFSYLTKHKIIHTGEKSYKCEEC-------GKG 381
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLLnssskfsPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 382 FNWSSTLTKHKRIHTGEKPYKCEV--CGKAFNESSNLTTHKMIHTGEKP--YKCEECGKAFNRSPQLTAHKIIHTGEKPY 457
Cdd:COG5048  368 NNEPPQSLQQYKDLKNDKKSETLSnsCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 981220777 458 KCEECGKAFSQSSILTTHK 476
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
483-564 8.56e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 48.54  E-value: 8.56e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 483 KPYKCEECGKAFNRSSNLTKHKIIHTGEKSYKCEECGKAFNQSST--LTKHRKIHTRQKPYNCEECDNTFNQSSNLIKQN 560
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPleLSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111


                 ....
gi 981220777 561 NSYW 564
Cdd:COG5048  112 SSSS 115
zf-H2C2_2 pfam13465
Zinc-finger double domain;
248-272 2.48e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 41.20  E-value: 2.48e-05
                          10        20
                  ....*....|....*....|....*
gi 981220777  248 LTRHKRIHTGEKPFKCEECGKAFKQ 272
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 413-533 1.11e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.71  E-value: 1.11e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 413 SSNLTTHKMIHTGEKPYKCEECGKAFNRSPQLT----AHKIIHTGEKPYKCE--ECGKAFSQSSILTTHKrihtgekpyK 486
Cdd:COG5189  302 RGGISTGEMIDVRKLPCTNSSSNGKLAHGGERNidtpSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYHM---------L 372

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*..
gi 981220777 487 CEECGKAFNRSSNLTKHKIIHTGEKSYKCEECGKAFNQSSTLTKHRK 533
Cdd:COG5189  373 HGHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
472-496 1.40e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 1.40e-04
                          10        20
                  ....*....|....*....|....*
gi 981220777  472 LTTHKRIHTGEKPYKCEECGKAFNR 496
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 341-420 1.69e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.69e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 341 GEKPYKCE--ECDKAFNRFSYLTKHKIihTGEKSYKCEEcgkgfnwSSTLTKHKRIHTGEKPYKCEVCGKAFNESSNLTT 418
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHE-------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 981220777 419 HK 420
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
388-411 2.29e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.29e-04
                          10        20
                  ....*....|....*....|....
gi 981220777  388 LTKHKRIHTGEKPYKCEVCGKAFN 411
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
415-440 2.48e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.48e-04
                          10        20
                  ....*....|....*....|....*.
gi 981220777  415 NLTTHKMIHTGEKPYKCEECGKAFNR 440
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
303-328 2.79e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 2.79e-04
                          10        20
                  ....*....|....*....|....*.
gi 981220777  303 HLTTHKIIHTGEKPYKCEECGKAFNQ 328
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 257-336 3.70e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.70e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 257 GEKPFKCE--ECGKAFKQSSTLTTHKIiHTgekpyrceECGKAFNRSSHLTTHKIIHTGEKPYKCEECGKAFNQSSTLST 334
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HG--------HQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ..
gi 981220777 335 HK 336
Cdd:COG5189  417 HR 418
zf-H2C2_2 pfam13465
Zinc-finger double domain;
499-524 6.06e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.06e-04
                          10        20
                  ....*....|....*....|....*.
gi 981220777  499 NLTKHKIIHTGEKSYKCEECGKAFNQ 524
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
276-300 9.70e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 9.70e-04
                          10        20
                  ....*....|....*....|....*
gi 981220777  276 LTTHKIIHTGEKPYRCEECGKAFNR 300
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
444-468 1.35e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.35e-03
                          10        20
                  ....*....|....*....|....*
gi 981220777  444 LTAHKIIHTGEKPYKCEECGKAFSQ 468
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 397-448 2.63e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.63e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 981220777 397 GEKPYKCEV--CGKAFNESSNLTTHKM-------------------IHTGEKPYKCEECGKAFNRSPQLTAHK 448
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYHR 418
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 285-363 2.97e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.97e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 981220777 285 GEKPYRCE--ECGKAFNRSSHLTTHKIiHTGEKPykceecgKAFNQSSTLSTHKFIhAGEKPYKCEECDKAF---NRFSY 359
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML-HGHQNQ-------KLHENPSPEKMNIFS-AKDKPYRCEVCDKRYknlNGLKY 416


                 ....
gi 981220777 360 LTKH 363
Cdd:COG5189  417 HRKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
193-214 3.18e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.18e-03
                          10        20
                  ....*....|....*....|..
gi 981220777  193 NRHKTRHTGKKPFKCKKCGKSF 214
Cdd:pfam13465   3 KRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 485-507 3.97e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.97  E-value: 3.97e-03
                          10        20
                  ....*....|....*....|...
gi 981220777  485 YKCEECGKAFNRSSNLTKHKIIH 507
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 513-535 4.88e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 4.88e-03
                          10        20
                  ....*....|....*....|...
gi 981220777  513 YKCEECGKAFNQSSTLTKHRKIH 535
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
359-383 6.52e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 6.52e-03
                          10        20
                  ....*....|....*....|....*
gi 981220777  359 YLTKHKIIHTGEKSYKCEECGKGFN 383
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
332-356 7.49e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.49e-03
                          10        20
                  ....*....|....*....|....*
gi 981220777  332 LSTHKFIHAGEKPYKCEECDKAFNR 356
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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