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Conserved domains on  [gi|974141063|ref|NP_001305822|]
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zinc finger protein 184 isoform 2 [Homo sapiens]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-660 4.11e-12

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 4.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 284 KPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCN--ECGKAFNGPSTFIRHHMIHTGEKPYEC----------------N 345
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 346 ECGKAFSQHSNLTQHQKTHTGEKP----------YDCAECGKSFSYWSSLAQHLKIHtgeKPYKCNECGKAFSYCSSLTQ 415
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 416 HRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGS 495
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 496 SLIQHRKIHTGER-------PYKCNECGRAFNQNIHLTQHKR--IHTG--AKPYECAE--CGKAFRHCSSLAQHQKTHTE 562
Cdd:COG5048  269 SSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 563 EKPYQC--NKCEKTFSQSSH-----LTQHQRIHTGEKPYKC--NECDKAFSRSTHLTEHQNTHTGEKPYNCN--ECRKTF 631
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        410       420
                 ....*....|....*....|....*....
gi 974141063 632 SQSTYLIQHQRIHSGEKPFGCNDCGKSFR 660
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-333 4.41e-05

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 172 KPYKCNECEKAFSRSENLINHQR--IHTG--DKPYKCD--QCGKGFIEGPSLTQHQRIHTGEKPYKC--DECGKAFSQ-- 241
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 242 ----RTHLVQHQRIHTGEKPYTC-NECGKAFSQRGHFMEHQKIHTGEKP--FKCDECDKTFTRSTHLTQHQKIHTgEKTY 314
Cdd:COG5048  368 nnepPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170
                 ....*....|....*....
gi 974141063 315 KCNECGKAFNGPSTFIRHH 333
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-660 4.11e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 4.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 284 KPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCN--ECGKAFNGPSTFIRHHMIHTGEKPYEC----------------N 345
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 346 ECGKAFSQHSNLTQHQKTHTGEKP----------YDCAECGKSFSYWSSLAQHLKIHtgeKPYKCNECGKAFSYCSSLTQ 415
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 416 HRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGS 495
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 496 SLIQHRKIHTGER-------PYKCNECGRAFNQNIHLTQHKR--IHTG--AKPYECAE--CGKAFRHCSSLAQHQKTHTE 562
Cdd:COG5048  269 SSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 563 EKPYQC--NKCEKTFSQSSH-----LTQHQRIHTGEKPYKC--NECDKAFSRSTHLTEHQNTHTGEKPYNCN--ECRKTF 631
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        410       420
                 ....*....|....*....|....*....
gi 974141063 632 SQSTYLIQHQRIHSGEKPFGCNDCGKSFR 660
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-333 4.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 172 KPYKCNECEKAFSRSENLINHQR--IHTG--DKPYKCD--QCGKGFIEGPSLTQHQRIHTGEKPYKC--DECGKAFSQ-- 241
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 242 ----RTHLVQHQRIHTGEKPYTC-NECGKAFSQRGHFMEHQKIHTGEKP--FKCDECDKTFTRSTHLTQHQKIHTgEKTY 314
Cdd:COG5048  368 nnepPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170
                 ....*....|....*....
gi 974141063 315 KCNECGKAFNGPSTFIRHH 333
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
580-605 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  580 HLTQHQRIHTGEKPYKCNECDKAFSR 605
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 2.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  216 SLTQHQRIHTGEKPYKCDECGKAFSQ 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 284-324 2.76e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 974141063 284 KPFkCDECDKTFTRSTHLTQHQKihtgEKTYKCNECGKAFN 324
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLY 36
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
284-660 4.11e-12

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 68.95  E-value: 4.11e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 284 KPFKCDECDKTFTRSTHLTQHQKIHTGEKTYKCN--ECGKAFNGPSTFIRHHMIHTGEKPYEC----------------N 345
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNskslplsnskasssslS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 346 ECGKAFSQHSNLTQHQKTHTGEKP----------YDCAECGKSFSYWSSLAQHLKIHtgeKPYKCNECGKAFSYCSSLTQ 415
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPqlpdllsisnLRNNPLPGNNSSSVNTPQSNSLH---PPLPANSLSKDPSSNLSLLI 188

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 416 HRRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKECGKAFIRSSSLAKHERIHTGEKPYQCHECGKTFSYGS 495
Cdd:COG5048  189 SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTA 268

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 496 SLIQHRKIHTGER-------PYKCNECGRAFNQNIHLTQHKR--IHTG--AKPYECAE--CGKAFRHCSSLAQHQKTHTE 562
Cdd:COG5048  269 SSQSSSPNESDSSsekgfslPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPYslCGKLFSRNDALKRHILLHTS 348

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 563 EKPYQC--NKCEKTFSQSSH-----LTQHQRIHTGEKPYKC--NECDKAFSRSTHLTEHQNTHTGEKPYNCN--ECRKTF 631
Cdd:COG5048  349 ISPAKEklLNSSSKFSPLLNneppqSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSF 428

                        410       420
                 ....*....|....*....|....*....
gi 974141063 632 SQSTYLIQHQRIHSGEKPFGCNDCGKSFR 660
Cdd:COG5048  429 NRHYNLIPHKKIHTNHAPLLCSILKSFRR 457
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
107-579 4.41e-11

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 65.49  E-value: 4.41e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 107 FGKSVNVSSNLVTQEPSPEETSTKRSIKQNSNPvkkeksckCNECGKAFSYCSALIRHQRTHTGEKPYKCN--ECEKAFS 184
Cdd:COG5048    3 LTSSQSSSSNNSVLSSTPKSTLKSLSNAPRPDS--------CPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFS 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 185 RSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIHTGEkPYKCDECGKAFSQRTHLVQHQRIHTGEKpYTCNECG 264
Cdd:COG5048   75 RPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLSSSSSNS-NDNNLLSSHSLPPSSRDPQLPDLLSISN-LRNNPLP 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 265 KAFSQRGHFMEHQKIHtGEKPFKCDECDKTFTRSTHLtqHQKIHTGEKTYKCNECGKAFNGPSTFIRHHMIHTGEKPYEC 344
Cdd:COG5048  153 GNNSSSVNTPQSNSLH-PPLPANSLSKDPSSNLSLLI--SSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPL 229

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 345 NECGKAFSQHSNLTQHQKTHTGEKPYDCAECGKSFSYWSSLAQHLKIHTGE-------KPYKCNECGKAFSYCSSLTQHR 417
Cdd:COG5048  230 TTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHL 309

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 418 R--IHTRE--KPFECSE--CGKAFSYLSNLNQHQKTHTQEKAYECKecgkaFIRSSSLAKherihtgekpyqchecGKTF 491
Cdd:COG5048  310 RsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEK-----LLNSSSKFS----------------PLLN 368

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 492 SYGSSLIQHRKIHTGERPYKC--NECGRAFNQNIHLTQHKRIHTGAKPYEC--AECGKAFRHCSSLAQHQKTHTEEKPYQ 567
Cdd:COG5048  369 NEPPQSLQQYKDLKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAPLL 448

                        490
                 ....*....|..
gi 974141063 568 CNKCEKTFSQSS 579
Cdd:COG5048  449 CSILKSFRRDLD 460
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
340-675 1.30e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 57.78  E-value: 1.30e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 340 KPYECNECGKAFSQHSNLTQHQKTHTGEKPYDCA--ECGKSFSYWSSLAQHLKIHTGEKPYKCN-ECGKAFSYCSSLTQH 416
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 417 RRIHTREKPFECSECGKAFSYLSNLNQHQKTHTQEKAYECKEC-GKAFIRSSSLAKHERIHTgekpyqcHECGKTFSYGS 495
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQLPDLLSISNLRNNPLPGNnSSSVNTPQSNSLHPPLPA-------NSLSKDPSSNL 184

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 496 SLIQHRKIHTGERPYKCNECGRAFNQNIHLTQHKRIHTGAKPYECAECgkafrhcsslaqhqkthteekpYQCNKCEKTF 575
Cdd:COG5048  185 SLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTN----------------------SQLSPKSLLS 242

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 576 SQSSHLTQHQRIHTGEKPYKCNECDKAFSRSTHLTEHQNTHTG-EKPYNCNECRKTFSQSTYLIQHQR--IHSGE--KPF 650
Cdd:COG5048  243 QSPSSLSSSDSSSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPF 322

                        330       340
                 ....*....|....*....|....*..
gi 974141063 651 GC--NDCGKSFRYRSALNKHQRLHPGI 675
Cdd:COG5048  323 SCpySLCGKLFSRNDALKRHILLHTSI 349
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
172-333 4.41e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 46.61  E-value: 4.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 172 KPYKCNECEKAFSRSENLINHQR--IHTG--DKPYKCD--QCGKGFIEGPSLTQHQRIHTGEKPYKC--DECGKAFSQ-- 241
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGesLKPFSCPysLCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPll 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 242 ----RTHLVQHQRIHTGEKPYTC-NECGKAFSQRGHFMEHQKIHTGEKP--FKCDECDKTFTRSTHLTQHQKIHTgEKTY 314
Cdd:COG5048  368 nnepPQSLQQYKDLKNDKKSETLsNSCIRNFKRDSNLSLHIITHLSFRPynCKNPPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170
                 ....*....|....*....
gi 974141063 315 KCNECGKAFNGPSTFIRHH 333
Cdd:COG5048  447 LLCSILKSFRRDLDLSNHG 465
zf-H2C2_2 pfam13465
Zinc-finger double domain;
580-605 1.88e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.88e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  580 HLTQHQRIHTGEKPYKCNECDKAFSR 605
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
216-241 2.18e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 2.18e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  216 SLTQHQRIHTGEKPYKCDECGKAFSQ 241
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
160-185 3.19e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 3.19e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  160 ALIRHQRTHTGEKPYKCNECEKAFSR 185
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
384-409 4.00e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.12  E-value: 4.00e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  384 SLAQHLKIHTGEKPYKCNECGKAFSY 409
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
244-269 4.72e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.72e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  244 HLVQHQRIHTGEKPYTCNECGKAFSQ 269
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
272-297 4.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.74  E-value: 4.91e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  272 HFMEHQKIHTGEKPFKCDECDKTFTR 297
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
468-493 6.16e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 37.35  E-value: 6.16e-04
                          10        20
                  ....*....|....*....|....*.
gi 974141063  468 SLAKHERIHTGEKPYQCHECGKTFSY 493
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
356-381 1.21e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.21e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  356 NLTQHQKTHTGEKPYDCAECGKSFSY 381
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
440-465 2.51e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.81  E-value: 2.51e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  440 NLNQHQKTHTQEKAYECKECGKAFIR 465
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 284-324 2.76e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 37.15  E-value: 2.76e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|.
gi 974141063 284 KPFkCDECDKTFTRSTHLTQHQKihtgEKTYKCNECGKAFN 324
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQK----AKHFKCHICHKKLY 36
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 122-248 2.91e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.47  E-value: 2.91e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 122 PSPEETSTKRSIKQNSNPVK-------KEKSCKCNECGKAFSYCSALI-----RHQRThTGEKPYKCN--ECEKAFsRSE 187
Cdd:COG5189  287 FDYEFIHKSVGNKEIRGGIStgemidvRKLPCTNSSSNGKLAHGGERNidtpsRMLKV-KDGKPYKCPveGCNKKY-KNQ 364

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 974141063 188 NLINHQRIHtgdkpykcDQCGKGFIEGPSLTQHQRIHTGEKPYKCDECGKAFSQRTHLVQH 248
Cdd:COG5189  365 NGLKYHMLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKYH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
300-324 3.24e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.24e-03
                          10        20
                  ....*....|....*....|....*
gi 974141063  300 HLTQHQKIHTGEKTYKCNECGKAFN 324
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFK 25
zf-H2C2_2 pfam13465
Zinc-finger double domain;
188-211 3.37e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 3.37e-03
                          10        20
                  ....*....|....*....|....
gi 974141063  188 NLINHQRIHTGDKPYKCDQCGKGF 211
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
524-549 3.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  524 HLTQHKRIHTGAKPYECAECGKAFRH 549
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
412-437 4.10e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.10e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  412 SLTQHRRIHTREKPFECSECGKAFSY 437
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
496-521 4.99e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.99e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  496 SLIQHRKIHTGERPYKCNECGRAFNQ 521
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 342-364 6.22e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.22e-03
                          10        20
                  ....*....|....*....|...
gi 974141063  342 YECNECGKAFSQHSNLTQHQKTH 364
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 566-588 6.28e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 6.28e-03
                          10        20
                  ....*....|....*....|...
gi 974141063  566 YQCNKCEKTFSQSSHLTQHQRIH 588
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
552-577 7.39e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 7.39e-03
                          10        20
                  ....*....|....*....|....*.
gi 974141063  552 SLAQHQKTHTEEKPYQCNKCEKTFSQ 577
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 282-365 7.66e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 39.32  E-value: 7.66e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 974141063 282 GEKPFKCD--ECDKTFTRSTHLTQHQKI-HTGEKTYKcnecgkafnGPSTfIRHHMIHTGEKPYECNECGKAFSQHSNLT 358
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHMLHgHQNQKLHE---------NPSP-EKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 974141063 359 QHQKTHT 365
Cdd:COG5189  416 YHRKHSH 422
zf-H2C2_2 pfam13465
Zinc-finger double domain;
331-353 9.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 9.00e-03
                          10        20
                  ....*....|....*....|...
gi 974141063  331 RHHMIHTGEKPYECNECGKAFSQ 353
Cdd:pfam13465   4 RHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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