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Conserved domains on  [gi|972781980|ref|NP_001305453|]
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trafficking protein particle complex subunit 2-like protein isoform 1 [Homo sapiens]

Protein Classification

trafficking protein particle complex subunit 2-like protein( domain architecture ID 13000929)

trafficking protein particle complex subunit 2-like protein (TRAPPC2L) plays a role in vesicular transport from endoplasmic reticulum to Golgi

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-142 1.15e-70

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


:

Pssm-ID: 341444  Cd Length: 135  Bit Score: 208.60  E-value: 1.15e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   3 VCIAVIAKENYPLYIRSTP--TENELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854    1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972781980  81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSMM 142
Cdd:cd14854   80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPIT-------SKKFDRRVDSLV 134
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-142 1.15e-70

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 208.60  E-value: 1.15e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   3 VCIAVIAKENYPLYIRSTP--TENELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854    1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972781980  81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSMM 142
Cdd:cd14854   80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPIT-------SKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 7-144 2.68e-42

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 136.62  E-value: 2.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980    7 VIAKENYPLYIRSTPTENELK-------FHYMVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 79
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEdkehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972781980   80 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSMMIQ 144
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIR-------SPAFDKKVRKLAKK 129
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-126 1.79e-10

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 55.30  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   1 MAVCIAVIAKENYPLYIRSTPTENELKF--------HYMVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 72
Cdd:COG5603    1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972781980  73 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSG 126
Cdd:COG5603   74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQA 123
 
Name Accession Description Interval E-value
TRAPPC2L cd14854
Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex ...
 3-142 1.15e-70

Trafficking protein particle complex subunit 2-like; Trafficking protein particle complex subunit 2-like (TRAPPC2L) is related to TRAPPC2. Its function is not known, but there are indications that it is part of the TRAPP II complex, which is required for distinct tethering events at Golgi membranes. TRAPPC2 has been identified as a general component of transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341444  Cd Length: 135  Bit Score: 208.60  E-value: 1.15e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   3 VCIAVIAKENYPLYIRSTP--TENELKFHYMVHTSLDVVDEKISAMGKAlVDQRELYLGLLYPTEDYKVYGYVTNSKVKF 80
Cdd:cd14854    1 VCVAVIGKQNNPLYLRTFPsgEDNDLKLHYIAHSSLDVVEEKLSASKKG-GDTSDMYLGLLYPTEDYKVYGYVTNTKVKF 79

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 972781980  81 VMVVDSSNTALRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSMM 142
Cdd:cd14854   80 ILVLEDTNTPLRDNDVRTLFRRLHNAYVDAVSNPFYPPGTPIT-------SKKFDRRVDSLV 134
Sedlin_N pfam04628
Sedlin, N-terminal conserved region; Mutations in this protein are associated with the ...
 7-144 2.68e-42

Sedlin, N-terminal conserved region; Mutations in this protein are associated with the X-linked spondyloepiphyseal dysplasia tarda syndrome (OMIM:313400). This family represents an N-terminal conserved region.


Pssm-ID: 335859  Cd Length: 129  Bit Score: 136.62  E-value: 2.68e-42
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980    7 VIAKENYPLYIRSTPTENELK-------FHYMVHTSLDVVDEKISAmgkalvdQRELYLGLLYPTEDYKVYGYVTNSKVK 79
Cdd:pfam04628   1 IIGKKDNPLYEQEFSTSGQTEdkehkhlNQFIAHASLDIVDELQWK-------TNNMYLGTIDKFYKLSVSAYVTNSHIK 73

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972781980   80 FVMVVDSSNtaLRDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSMMIQ 144
Cdd:pfam04628  74 FILVHESST--KSDENIKQFFQEVHELYVKTLMNPFYKPNDPIR-------SPAFDKKVRKLAKK 129
TRAPPC_longin-like cd14853
Longin-like domains of Trafficking protein particle complex; Longin-like domains of a ...
 3-141 3.51e-18

Longin-like domains of Trafficking protein particle complex; Longin-like domains of a subfamily of core components of the trafficking protein particle complex (TRAPP), including TRAPPC2, TRAPPC4, TRAPPC1 and a TRAPPC2L, whose function is not known. TRAPP complexes are required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341443  Cd Length: 132  Bit Score: 75.21  E-value: 3.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   3 VCIAVIAKENYPLYIRS--------TPTENELKFHYMVHTSLDVVDEKISamgkalvDQRELYLGLLYPTEDYKVYGYVT 74
Cdd:cd14853    1 FYFVVVGHHGNPLYEREftppgqaeDDNEEEYKLLAGMLHSVRSINSKLS-------PNVEKYLKLSDKTNEYKVHAYVT 73

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 972781980  75 NSKVKFVMVVDSSNTALRDNeIRSMFRKLHNSYTDVMCNPFYNPGDRIQssgsvslSRAFDNMVTSM 141
Cdd:cd14853   74 ATGLKFVMLTDVLMDRIEDV-LKNFFSDLYVLYVKKNPNPFYEPNSPIR-------SRLFDSKVQSL 132
TRAPPC2_sedlin cd14825
Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 ...
 6-126 4.04e-14

Trafficking protein particle complex subunit 2; Trafficking protein particle complex subunit 2 (TRAPPC2), also known as Sedlin (SEDL) or TRS20, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic. In humans, deletions or point mutations in the SEDL gene cause the genetic disease spondyloepiphyseal dysplasia tarda (SEDT), an X-linked skeletal disorder.


Pssm-ID: 341429  Cd Length: 135  Bit Score: 64.47  E-value: 4.04e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   6 AVIAKENYPLYIRSTPTENELKF--------HYMVHTSLDVVDEKISAMGKalvdqreLYLGLLYPTEDYKVYGYVTNSK 77
Cdd:cd14825    5 VIVGPNDNPLYEAEFGSSKKSEFrddhrhlnQFIAHAALDLVDELQWTTNN-------MYLKSVDRFNEWSVSAFVTAGN 77

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*....
gi 972781980  78 VKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSG 126
Cdd:cd14825   78 IRFLLLHDNKN----DDGIKNFFQEVYELYVKILMNPFYEPNTPIRSPA 122
TRS20 COG5603
Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];
1-126 1.79e-10

Subunit of TRAPP, an ER-Golgi tethering complex [Cell motility and secretion];


Pssm-ID: 227890  Cd Length: 136  Bit Score: 55.30  E-value: 1.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972781980   1 MAVCIAVIAKENYPLYIRSTPTENELKF--------HYMVHTSLDVVDEKISAMGKAlvdqrelYLGLLYPTEDYKVYGY 72
Cdd:COG5603    1 MGEYLAIIGEKDNPVYEREYDPINKTSDgeycrllnQFIIHASLDIVVWLQWSVNTS-------YFDCLDSFGDLRISAY 73

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972781980  73 VTNSKVKFVMVVDSSNtalrDNEIRSMFRKLHNSYTDVMCNPFYNPGDRIQSSG 126
Cdd:COG5603   74 IMPSGMKFLFIHQNQS----RKNARSFLQEVHELYAKTLMSPFYEPDEPIRSQA 123
TRAPPC4_synbindin cd14856
Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 ...
 64-116 1.06e-03

Trafficking protein particle complex subunit 4; Trafficking protein particle complex subunit 4 (TRAPPC4), also known as synbindin or TRS23, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341446  Cd Length: 127  Bit Score: 36.73  E-value: 1.06e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972781980  64 TEDYKVYGYVTNSKVKFVMVVDSSNTALRdneirSMFRKLHNSYTD-VMCNPFY 116
Cdd:cd14856   61 TDTFRLHCFQTLTGIKFVLVADPKQPGLD-----ALLRRVYELYADyVLKNPFY 109
TRAPPC1_MUM2 cd14855
Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 ...
 62-124 5.16e-03

Trafficking protein particle complex subunit 1; Trafficking protein particle complex subunit 1 (TRAPPC1), also known as MUM2 and BET5, has been identified as a component of the transport protein particle (TRAPP), required for tethering endoplasmic reticulum (ER)-derived vesicles to Golgi membranes and for Golgi traffic.


Pssm-ID: 341445  Cd Length: 132  Bit Score: 34.83  E-value: 5.16e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 972781980  62 YPTEDYKVYGYVTNSKVKFVMVVDSSNTALRDnEIRSMFRKLHNSYtdVMCNPFYNPGDRIQS 124
Cdd:cd14855   63 YTTNKYKLHYYETPTGLKFVLLTDPNVGDLRD-VLQQIYSNIYVEY--VVKNPLYPPGEPITS 122
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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