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Conserved domains on  [gi|972775802|ref|NP_001305406|]
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tsukushi isoform a precursor [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 11469232)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-321 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


:

Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  98 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 175
Cdd:COG4886   96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 176 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 252
Cdd:COG4886  165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 253 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 321
Cdd:COG4886  239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-321 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  98 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 175
Cdd:COG4886   96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 176 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 252
Cdd:COG4886  165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 253 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 321
Cdd:COG4886  239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR_8 pfam13855
Leucine rich repeat;
103-157 6.41e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 6.41e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 972775802  103 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSHNQL 157
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-188 2.27e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  77 LDLSSNRL-EMVNESVLAGPgytTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSH 154
Cdd:PLN00113 480 LDLSRNQFsGAVPRKLGSLS---ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972775802 155 NQLrevsvSAFTTHSQGRA---LHVDLSHNLIHRLVP 188
Cdd:PLN00113 557 NQL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-305 6.30e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 6.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  52 SLTRVDCSGLGPHIMPVPiplDTAHLDLSSNRLEMVNESV-LAGPGYTTLAGL---DLSHNLLTSISPTAFSRLR---YL 124
Cdd:cd00116   34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 125 ESLDLSHNGL----TALPAESFTSSP--LSDVNLSHNQLrevsvsaftTHSQGRALHVDLSHNlihrlvphptraglpaP 198
Cdd:cd00116  111 QELKLNNNGLgdrgLRLLAKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 199 TIQSLNLAWNRLHA------VPNLRDLP-LRYLSLDGNPLAVIGPGAFAGlgglthlslaslqrlpelapsGFRELPGLQ 271
Cdd:cd00116  166 DLKELNLANNGIGDagiralAEGLKANCnLEVLDLNNNGLTDEGASALAE---------------------TLASLKSLE 224

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 972775802 272 VLDLSGNPKLNWAGAEVFSGL----SSLQELDLSGTNL 305
Cdd:cd00116  225 VLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDI 262
 
Name Accession Description Interval E-value
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
98-321 2.55e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 82.67  E-value: 2.55e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  98 TTLAGLDLSHNlltsispTAFSRLRYLESLDLSHNGLTALPAE--SFTSspLSDVNLSHNQLREVSvSAFTTHSQGRALh 175
Cdd:COG4886   96 TNLTELDLSGN-------EELSNLTNLESLDLSGNQLTDLPEElaNLTN--LKELDLSNNQLTDLP-EPLGNLTNLKSL- 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 176 vDLSHNLIHRLvphpTRAGLPAPTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLDGNPLAVIgPGAFAGLGGLTHLSLAS- 252
Cdd:COG4886  165 -DLSNNQLTDL----PEELGNLTNLKELDLSNNQITDLPEpLGNLTnLEELDLSGNQLTDL-PEPLANLTNLETLDLSNn 238

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 253 -LQRLPELApsgfrELPGLQVLDLSGNpKLNWAGAEvfSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 321
Cdd:COG4886  239 qLTDLPELG-----NLTNLEELDLSNN-QLTDLPPL--ANLTNLKTLDLSNNQLTDLKLKELELLLGLNS 300
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
77-328 5.27e-17

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 81.90  E-value: 5.27e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  77 LDLSSNRLEMVNESVlagPGYTTLAGLDLSHNLLTSIsPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQ 156
Cdd:COG4886  118 LDLSGNQLTDLPEEL---ANLTNLKELDLSNNQLTDL-PEPLGNLTNLKSLDLSNNQLTDLPEELGNLTNLKELDLSNNQ 193

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 157 LREVSvSAFtthSQGRAL-HVDLSHNLIHRLvPHPTrAGLPAptIQSLNLAWNRLHAVPNLRDLP-LRYLSLDGNPLAVI 234
Cdd:COG4886  194 ITDLP-EPL---GNLTNLeELDLSGNQLTDL-PEPL-ANLTN--LETLDLSNNQLTDLPELGNLTnLEELDLSNNQLTDL 265

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 235 GPgaFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGNPKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLL 314
Cdd:COG4886  266 PP--LANLTNLKTLDL-SNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLAL 342

                        250
                 ....*....|....
gi 972775802 315 HLPALQSVSVGQDV 328
Cdd:COG4886  343 SLSLLALLTLLLLL 356
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
72-324 1.16e-15

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 77.67  E-value: 1.16e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  72 LDTAHLDLSSNRLEMVNESVLAGPGYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNgltalpAESFTSSPLSDVN 151
Cdd:COG4886   46 LLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGN------EELSNLTNLESLD 119

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 152 LSHNQLREVSVSAftthSQGRAL-HVDLSHNLIHRLVPhptraGLPA-PTIQSLNLAWNRLHAVPN-LRDLP-LRYLSLD 227
Cdd:COG4886  120 LSGNQLTDLPEEL----ANLTNLkELDLSNNQLTDLPE-----PLGNlTNLKSLDLSNNQLTDLPEeLGNLTnLKELDLS 190

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 228 GNPLAVIgPGAFAGLGGLTHLSLAS--LQRLPElapsGFRELPGLQVLDLSGNP--KLNWagaevFSGLSSLQELDLSGT 303
Cdd:COG4886  191 NNQITDL-PEPLGNLTNLEELDLSGnqLTDLPE----PLANLTNLETLDLSNNQltDLPE-----LGNLTNLEELDLSNN 260

                        250       260
                 ....*....|....*....|.
gi 972775802 304 NLVPLPEalLLHLPALQSVSV 324
Cdd:COG4886  261 QLTDLPP--LANLTNLKTLDL 279
LRR_8 pfam13855
Leucine rich repeat;
103-157 6.41e-10

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 54.45  E-value: 6.41e-10
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 972775802  103 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSHNQL 157
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPsLRYLDLSGNRL 61
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-188 2.27e-09

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 59.09  E-value: 2.27e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  77 LDLSSNRL-EMVNESVLAGPgytTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSP-LSDVNLSH 154
Cdd:PLN00113 480 LDLSRNQFsGAVPRKLGSLS---ELMQLKLSENKLSGEIPDELSSCKKLVSLDLSHNQLSGQIPASFSEMPvLSQLDLSQ 556

                         90       100       110
                 ....*....|....*....|....*....|....*..
gi 972775802 155 NQLrevsvSAFTTHSQGRA---LHVDLSHNLIHRLVP 188
Cdd:PLN00113 557 NQL-----SGEIPKNLGNVeslVQVNISHNHLHGSLP 588
LRR_8 pfam13855
Leucine rich repeat;
77-134 2.90e-09

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 52.53  E-value: 2.90e-09
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 972775802   77 LDLSSNRLEMVNESVLAGPgyTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGL 134
Cdd:pfam13855   6 LDLSNNRLTSLDDGAFKGL--SNLKVLDLSNNLLTTLSPGAFSGLPSLRYLDLSGNRL 61
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
76-275 7.15e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 56.87  E-value: 7.15e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  76 HLDLSSNRLEMVNESVlagPGYTTLAGLDLSHNLLTSISptAFSRLRYLESLDLSHNGLTALPAESFTSSpLSDVNLSHN 155
Cdd:COG4886  209 ELDLSGNQLTDLPEPL---ANLTNLETLDLSNNQLTDLP--ELGNLTNLEELDLSNNQLTDLPPLANLTN-LKTLDLSNN 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 156 QLREVSVSAFTTHSQGRALHVDLSHNLIHRLVPHPTRAGLPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIG 235
Cdd:COG4886  283 QLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLVTLTTLALSLSLLALLTLLLLLNLLSLL 362

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 972775802 236 PGAFAGLGGLTHLSLASLQRLPELAPSGFRELPGLQVLDL 275
Cdd:COG4886  363 LTLLLTLGLLGLLEATLLTLALLLLTLLLLLLTTTAGVLL 402
LRR_8 pfam13855
Leucine rich repeat;
221-279 1.94e-08

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 50.22  E-value: 1.94e-08
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*....
gi 972775802  221 LRYLSLDGNPLAVIGPGAFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGNP 279
Cdd:pfam13855   3 LRSLDLSNNRLTSLDDGAFKGLSNLKVLDL-SNNLLTTLSPGAFSGLPSLRYLDLSGNR 60
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
66-279 7.56e-08

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 54.32  E-value: 7.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  66 MPVPIPLDTAHLDLSSNRLEMVNESVlagPgyTTLAGLDLSHNLLTSISPTAFSRLRYlesLDLSHNGLTALPAEsfTSS 145
Cdd:PRK15370 235 IPATLPDTIQEMELSINRITELPERL---P--SALQSLDLFHNKISCLPENLPEELRY---LSVYDNSIRTLPAH--LPS 304

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 146 PLSDVNLSHNQLrevsvsaftthsqgRALHVDLSHNLIHRLVPHPTRAGLPA---PTIQSLNLAWNRLHAVPNLRDLPLR 222
Cdd:PRK15370 305 GITHLNVQSNSL--------------TALPETLPPGLKTLEAGENALTSLPAslpPELQVLDVSKNQITVLPETLPPTIT 370

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 972775802 223 YLSLDGNPLAVIGPGAFAGLGGLtHLSLASLQRLPELAPSGFRELPGLQVLDLSGNP 279
Cdd:PRK15370 371 TLDVSRNALTNLPENLPAALQIM-QASRNNLVRLPESLPHFRGEGPQPTRIIVEYNP 426
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
127-342 1.23e-07

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 53.55  E-value: 1.23e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 127 LDLSHNGLTALPA---ESFTSSPLSDVNLS------HNQLREVSVSAFTTHSQGRAL-----HVDLSHNLIHRLVPHptr 192
Cdd:PRK15370 183 LRLKILGLTTIPAcipEQITTLILDNNELKslpenlQGNIKTLYANSNQLTSIPATLpdtiqEMELSINRITELPER--- 259

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 193 agLPApTIQSLNLAWNRLHAVPNlrDLP--LRYLSLDGNPLAVIgPGAFAGlgGLTHLSLA--SLQRLPELAPSGFREL- 267
Cdd:PRK15370 260 --LPS-ALQSLDLFHNKISCLPE--NLPeeLRYLSVYDNSIRTL-PAHLPS--GITHLNVQsnSLTALPETLPPGLKTLe 331

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 268 --------------PGLQVLDLSGN-----PKlnwagaevfSGLSSLQELDLSGTNLVPLPEALLLHLPALQSvSVGQDV 328
Cdd:PRK15370 332 agenaltslpaslpPELQVLDVSKNqitvlPE---------TLPPTITTLDVSRNALTNLPENLPAALQIMQA-SRNNLV 401

                        250
                 ....*....|....*...
gi 972775802 329 RCRR----LVREGTYPRR 342
Cdd:PRK15370 402 RLPEslphFRGEGPQPTR 419
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 52-305 6.30e-07

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 50.43  E-value: 6.30e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  52 SLTRVDCSGLGPHIMPVPiplDTAHLDLSSNRLEMVNESV-LAGPGYTTLAGL---DLSHNLLTSISPTAFSRLR---YL 124
Cdd:cd00116   34 TLGEEAAKALASALRPQP---SLKELCLSLNETGRIPRGLqSLLQGLTKGCGLqelDLSDNALGPDGCGVLESLLrssSL 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 125 ESLDLSHNGL----TALPAESFTSSP--LSDVNLSHNQLrevsvsaftTHSQGRALHVDLSHNlihrlvphptraglpaP 198
Cdd:cd00116  111 QELKLNNNGLgdrgLRLLAKGLKDLPpaLEKLVLGRNRL---------EGASCEALAKALRAN----------------R 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 199 TIQSLNLAWNRLHA------VPNLRDLP-LRYLSLDGNPLAVIGPGAFAGlgglthlslaslqrlpelapsGFRELPGLQ 271
Cdd:cd00116  166 DLKELNLANNGIGDagiralAEGLKANCnLEVLDLNNNGLTDEGASALAE---------------------TLASLKSLE 224

                        250       260       270
                 ....*....|....*....|....*....|....*...
gi 972775802 272 VLDLSGNPKLNWAGAEVFSGL----SSLQELDLSGTNL 305
Cdd:cd00116  225 VLNLGDNNLTDAGAAALASALlspnISLLTLSLSCNDI 262
PRK15370 PRK15370
type III secretion system effector E3 ubiquitin transferase SlrP;
54-312 1.07e-06

type III secretion system effector E3 ubiquitin transferase SlrP;


Pssm-ID: 185268 [Multi-domain]  Cd Length: 754  Bit Score: 50.47  E-value: 1.07e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  54 TRVDCSGLGPHIMPVPIPLDTAHLDLSSNRLE-------------MVNESVLAGPGYT---TLAGLDLSHNLLTSIS--- 114
Cdd:PRK15370 181 TELRLKILGLTTIPACIPEQITTLILDNNELKslpenlqgniktlYANSNQLTSIPATlpdTIQEMELSINRITELPerl 260

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 115 PTAfsrlryLESLDLSHNGLTALPAesftssplsdvNLShNQLREVSVsaftTHSQGRALHVDLSHNLIHRLVPHPTRAG 194
Cdd:PRK15370 261 PSA------LQSLDLFHNKISCLPE-----------NLP-EELRYLSV----YDNSIRTLPAHLPSGITHLNVQSNSLTA 318

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 195 LPA---PTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVigpgafaglgglthlslaslqrLPELAPsgfrelPGLQ 271
Cdd:PRK15370 319 LPEtlpPGLKTLEAGENALTSLPASLPPELQVLDVSKNQITV----------------------LPETLP------PTIT 370

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|..
gi 972775802 272 VLDLSGNPKLNWAgaevfSGL-SSLQELDLSGTNLVPLPEAL 312
Cdd:PRK15370 371 TLDVSRNALTNLP-----ENLpAALQIMQASRNNLVRLPESL 407
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 76-231 7.62e-06

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 47.48  E-value: 7.62e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  76 HLDLSSNRLEmvNESVLAGPGY----TTLAGLDLSHNLLT-----SISpTAFSRLRYLESLDLSHN-----GLTALpAES 141
Cdd:COG5238  240 TLDLSNNQIG--DEGVIALAEAlknnTTVETLYLSGNQIGaegaiALA-KALQGNTTLTSLDLSVNrigdeGAIAL-AEG 315

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 142 F-TSSPLSDVNLSHNQLREVSVSAFTTHSQ-GRALH-VDLSHN---------LIHRLVPHptraglpaPTIQSLNLAWNR 209
Cdd:COG5238  316 LqGNKTLHTLNLAYNGIGAQGAIALAKALQeNTTLHsLDLSDNqigdegaiaLAKYLEGN--------TTLRELNLGKNN 387

                        170       180
                 ....*....|....*....|....*...
gi 972775802 210 LHAV------PNLRDLPLRYLSLDGNPL 231
Cdd:COG5238  388 IGKQgaealiDALQTNRLHTLILDGNLI 415
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 100-312 1.36e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 47.15  E-value: 1.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 100 LAGLDLS-HNLLTSISPTAFsRLRYLESLDLSHNGLTA-LPAESF-TSSPLSDVNLSHNQLREVSVSAFTTHSQGralhV 176
Cdd:PLN00113  71 VVSIDLSgKNISGKISSAIF-RLPYIQTINLSNNQLSGpIPDDIFtTSSSLRYLNLSNNNFTGSIPRGSIPNLET----L 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 177 DLSHNLIHRLVPhptraglpaptiQSLNLAWNrlhavpnlrdlpLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRL 256
Cdd:PLN00113 146 DLSNNMLSGEIP------------NDIGSFSS------------LKVLDLGGNVLVGKIPNSLTNLTSLEFLTLASNQLV 201

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 257 PELaPSGFRELPGLQVLDLSGNpklNWAGaEV---FSGLSSLQELDLSGTNLV-PLPEAL 312
Cdd:PLN00113 202 GQI-PRELGQMKSLKWIYLGYN---NLSG-EIpyeIGGLTSLNHLDLVYNNLTgPIPSSL 256
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 96-211 2.12e-05

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 46.38  E-value: 2.12e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  96 GYTTLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTA-LPAESFTSSPLSDVNLSHNQLR---EVSVSAFTTHSQg 171
Cdd:PLN00113 473 GSKRLENLDLSRNQFSGAVPRKLGSLSELMQLKLSENKLSGeIPDELSSCKKLVSLDLSHNQLSgqiPASFSEMPVLSQ- 551

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|
gi 972775802 172 ralhVDLSHNLIHRLVphPTRAGLPAPTIQsLNLAWNRLH 211
Cdd:PLN00113 552 ----LDLSQNQLSGEI--PKNLGNVESLVQ-VNISHNHLH 584
LRR_8 pfam13855
Leucine rich repeat;
122-183 6.76e-05

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 40.20  E-value: 6.76e-05
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 972775802  122 RYLESLDLSHNGLTALPAESFTS-SPLSDVNLSHNQLREVSVSAFtthSQGRAL-HVDLSHNLI 183
Cdd:pfam13855   1 PNLRSLDLSNNRLTSLDDGAFKGlSNLKVLDLSNNLLTTLSPGAF---SGLPSLrYLDLSGNRL 61
LRR_8 pfam13855
Leucine rich repeat;
268-321 1.86e-04

Leucine rich repeat;


Pssm-ID: 404697 [Multi-domain]  Cd Length: 61  Bit Score: 39.04  E-value: 1.86e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 972775802  268 PGLQVLDLSGNpKLNWAGAEVFSGLSSLQELDLSGTNLVPLPEALLLHLPALQS 321
Cdd:pfam13855   1 PNLRSLDLSNN-RLTSLDDGAFKGLSNLKVLDLSNNLLTTLSPGAFSGLPSLRY 53
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
195-325 3.55e-04

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 42.23  E-value: 3.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 195 LPAPTIQSLNLAWNRLHAVPNLRDLPLRYLSLDGNPLAVIGPGAFAGLGGLTHLSLASLQRLPELApsgfrELPGLQVLD 274
Cdd:COG4886   45 LLLLLTLLLSLLLRDLLLSSLLLLLSLLLLLLLSLLLLSLLLLGLTDLGDLTNLTELDLSGNEELS-----NLTNLESLD 119

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 972775802 275 LSGNpKLNWAGAEvFSGLSSLQELDLSGTNLVPLPEAlLLHLPALQSVSVG 325
Cdd:COG4886  120 LSGN-QLTDLPEE-LANLTNLKELDLSNNQLTDLPEP-LGNLTNLKSLDLS 167
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 77-278 3.71e-04

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 42.53  E-value: 3.71e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802  77 LDLSSNRLEMVNESVLAGPGYttLAGLDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSD-VNLSHN 155
Cdd:PLN00113 361 LDLSTNNLTGEIPEGLCSSGN--LFKLILFSNSLEGEIPKSLGACRSLRRVRLQDNSFSGELPSEFTKLPLVYfLDISNN 438

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 156 QLREVSVSAFTTHSQGRALhvDLSHNLIHRLVPHPTRAglpaPTIQSLNLAWNRLH-AVPN-LRDLP-LRYLSLDGNPLA 232
Cdd:PLN00113 439 NLQGRINSRKWDMPSLQML--SLARNKFFGGLPDSFGS----KRLENLDLSRNQFSgAVPRkLGSLSeLMQLKLSENKLS 512

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*.
gi 972775802 233 VIGPGAFAGLGGLTHLSLaSLQRLPELAPSGFRELPGLQVLDLSGN 278
Cdd:PLN00113 513 GEIPDELSSCKKLVSLDL-SHNQLSGQIPASFSEMPVLSQLDLSQN 557
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 103-228 2.86e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 39.83  E-value: 2.86e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 103 LDLSHNLLTSISPTAFSRLRYLESLDLSHNGLTALPAESFTSSPLSDVNLSHNQLREVSVSAFTTHSQgrALHVDLSHNL 182
Cdd:PLN00113 433 LDISNNNLQGRINSRKWDMPSLQMLSLARNKFFGGLPDSFGSKRLENLDLSRNQFSGAVPRKLGSLSE--LMQLKLSENK 510

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 972775802 183 IHRLVPHPTRAglpAPTIQSLNLAWNRLHA--------VPNLRDLPLRYLSLDG 228
Cdd:PLN00113 511 LSGEIPDELSS---CKKLVSLDLSHNQLSGqipasfseMPVLSQLDLSQNQLSG 561
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-155 3.00e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.61  E-value: 3.00e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 972775802 103 LDLSHNLLTSISPtaFSRLRYLESLDLSHNGLTALP--AESFTSSP-LSDVNLSHN 155
Cdd:cd21340  125 LNISGNNIDSLEP--LAPLRNLEQLDASNNQISDLEelLDLLSSWPsLRELDLTGN 178
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 197-302 3.99e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 38.23  E-value: 3.99e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 197 APTIQSLNLAWNRLHAVPNLRDLP-LRYLSLDGNPLAVIgpgafAGLGG---LTHLSLASlQRLPE-------------L 259
Cdd:cd21340   45 LTNLTHLYLQNNQIEKIENLENLVnLKKLYLGGNRISVV-----EGLENltnLEELHIEN-QRLPPgekltfdprslaaL 118

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 972775802 260 APS---------------GFRELPGLQVLDLSGNPKLNWAG-AEVFSGLSSLQELDLSG 302
Cdd:cd21340  119 SNSlrvlnisgnnidslePLAPLRNLEQLDASNNQISDLEElLDLLSSWPSLRELDLTG 177
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 103-232 6.52e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 6.52e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 972775802 103 LDLSHNLLTSISPtaFSRLRYLESLDLSHN------GLTALPAesftsspLSDVNLSHNQLREVSVSAF---TTHSQGRA 173
Cdd:cd21340   51 LYLQNNQIEKIEN--LENLVNLKKLYLGGNrisvveGLENLTN-------LEELHIENQRLPPGEKLTFdprSLAALSNS 121

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 972775802 174 LHV-DLSHNLIHRLVPhptRAGLPAptIQSLNLAWNRLHAVPNLRDL-----PLRYLSLDGNPLA 232
Cdd:cd21340  122 LRVlNISGNNIDSLEP---LAPLRN--LEQLDASNNQISDLEELLDLlsswpSLRELDLTGNPVC 181
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 76-138 9.83e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.07  E-value: 9.83e-03
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 972775802  76 HLDLSSNRLEMVNE-SVLagpgyTTLAGLDLSHNLLTSISPTA--FSRLRYLESLDLSHNGLTALP 138
Cdd:cd21340  124 VLNISGNNIDSLEPlAPL-----RNLEQLDASNNQISDLEELLdlLSSWPSLRELDLTGNPVCKKP 184
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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