|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-695 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1396.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 1 MEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVG 80
Cdd:PLN02437 98 VKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVNGKVVERPQHMLMRVSVG 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 81 IHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRA 160
Cdd:PLN02437 178 IHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRA 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 161 TGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDL 240
Cdd:PLN02437 258 TGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDL 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 241 FMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQ 320
Cdd:PLN02437 338 FMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQ 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 321 QNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV-------------------TSEHTYDFKKLAEVTKVVVRNLN 381
Cdd:PLN02437 418 QNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYFDFEKLAEVTAVVTRNLN 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 382 KIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEG 461
Cdd:PLN02437 498 KIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAG 577
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 462 SPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVN 541
Cdd:PLN02437 578 SPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVN 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 542 PHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYG 621
Cdd:PLN02437 658 KHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFG 737
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 968121915 622 KLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNT--AAMVCSLENRDECLMCGS 695
Cdd:PLN02437 738 KLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETkmAQMVCSLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
25-657 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 860.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 25 DIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSE 98
Cdd:COG0209 28 RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 99 RWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPM 178
Cdd:COG0209 108 LRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 179 LRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNE 258
Cdd:COG0209 187 MKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPRE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 259 CPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEY 338
Cdd:COG0209 266 VPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 339 TSKDEVAVCNLASLALNMYVTsEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILM 418
Cdd:COG0209 346 PYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKL 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 419 RYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGI 496
Cdd:COG0209 425 GIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGL 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 497 RNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEI 575
Cdd:COG0209 505 RNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDEL 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 576 PDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFT 654
Cdd:COG0209 584 PEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLST 662
|
...
gi 968121915 655 LNK 657
Cdd:COG0209 663 GKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
70-644 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 773.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 70 PQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAG 149
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 150 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRAR 229
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 230 DLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvvkaQQLWYAIIESQTETGTPYML 309
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 310 YKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTsehtydFKKLAEVTKVVVRNLNKII 384
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 385 DINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGpyetyegspv 464
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 465 skgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 544
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 545 LKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP-NYGKL 623
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 968121915 624 TSMHFYGWKQGLKTGmYYLRT 644
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
119-641 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 754.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 119 SSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 198
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 199 AFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASY 277
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 278 EKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY 357
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 358 VTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFET 437
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 438 IYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTA 511
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 512 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQ 591
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 968121915 592 KTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 641
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
48-645 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 745.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 48 YFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSS 120
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 121 CFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 200
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 201 AIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ 280
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 281 GRVRK---VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLA 353
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 354 LNMYVTSEhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQ 433
Cdd:TIGR02506 320 LANFVMED-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 434 IFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMP 506
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 507 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 586
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 587 WEISQKTVLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 645
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PLN02437 |
PLN02437 |
ribonucleoside--diphosphate reductase large subunit |
1-695 |
0e+00 |
|
ribonucleoside--diphosphate reductase large subunit
Pssm-ID: 178056 [Multi-domain] Cd Length: 813 Bit Score: 1396.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 1 MEDLYNYINPHNGKHSPMVAKSTLDIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVG 80
Cdd:PLN02437 98 VKDMYNHVNERSGLKAPLIADDVYDIIMKNAARLDSEIIYDRDFDYDYFGFKTLERSYLLKVNGKVVERPQHMLMRVSVG 177
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 81 IHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRA 160
Cdd:PLN02437 178 IHKDDIESAIKTYHLMSQRWFTHASPTLFNAGTPRPQLSSCFLICMKDDSIEGIYDTLKECAVISKSAGGIGLSVHNIRA 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 161 TGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDL 240
Cdd:PLN02437 258 TGSYIRGTNGTSNGIVPMLRVFNDTARYVDQGGGKRKGAFAIYLEPWHADIFEFLDLRKNHGKEEHRARDLFYALWIPDL 337
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 241 FMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQ 320
Cdd:PLN02437 338 FMERVQSNGDWSLFCPNEAPGLADCWGEEFERLYTKYEREGKAKKVVQAQQLWFAILESQIETGTPYMLFKDSCNRKSNQ 417
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 321 QNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV-------------------TSEHTYDFKKLAEVTKVVVRNLN 381
Cdd:PLN02437 418 QNLGTIKSSNLCTEIIEYTSPTETAVCNLASIALPRFVrekgvpleshpsklvgslgSKNRYFDFEKLAEVTAVVTRNLN 497
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 382 KIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEG 461
Cdd:PLN02437 498 KIIDVNYYPVETARRSNMRHRPIGIGVQGLADAFILLGMPFDSPEAQQLNKDIFETIYYHALKASSELAAREGPYETYAG 577
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 462 SPVSKGILQYDMWNVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVN 541
Cdd:PLN02437 578 SPVSKGILQPDMWGVTPSGRWDWAALREMISKNGVRNSLLVAPMPTASTSQILGNNECFEPYTSNIYSRRVLSGEFVVVN 657
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 542 PHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYG 621
Cdd:PLN02437 658 KHLLHDLTEMGLWTPTLKNKIIAENGSVQKIPEIPDDLKAIYKTVWEIKQRTLVDMAADRGCYIDQSQSLNIHMDQPNFG 737
|
650 660 670 680 690 700 710
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 968121915 622 KLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKVSKEEEEKERNT--AAMVCSLENRDECLMCGS 695
Cdd:PLN02437 738 KLTSLHFYAWSKGLKTGMYYLRSRAAADAIKFTVDTASLKPSATGVAAPEEEDVETkmAQMVCSLDNREECLACGS 813
|
|
| NrdA |
COG0209 |
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide ... |
25-657 |
0e+00 |
|
Ribonucleotide reductase alpha subunit [Nucleotide transport and metabolism]; Ribonucleotide reductase alpha subunit is part of the Pathway/BioSystem: Pyrimidine salvage
Pssm-ID: 439979 [Multi-domain] Cd Length: 665 Bit Score: 860.64 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 25 DIVLANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSE 98
Cdd:COG0209 28 RLLEEDLEELAAAIDPERDRFFSYNALKTLYDRYLLKdEDGKPLETPQDLFMRVAMGLAaaekpEDREEWAKEFYDLLSS 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 99 RWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPM 178
Cdd:COG0209 108 LRFLPATPTLFNAGTPRGQLSSCFVLPV-EDSLESIFDALKDAALLSKSGGGVGFNFSRLRPKGSPIKGTGGVSSGPVPF 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 179 LRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNE 258
Cdd:COG0209 187 MKVFDDAAVAVNQGG-KRRGANMVYLRVWHPDIEEFLDLKKNNGDERRRLHNFNISVWIPDLFMEAVEEDEDWTLFSPRE 265
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 259 CPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEY 338
Cdd:COG0209 266 VPDLYGLYGEEFEEAYEEYEADGRVYKTIKARELWRKILESAWETGEPGILFKDTINRRNPLPHLGVIHSSNLCGEIPLL 345
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 339 TSKDEVAVCNLASLALNMYVTsEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILM 418
Cdd:COG0209 346 PYESEDASCNLGSINLAKFVK-DGEFDWEKLEETVRTAVRFLDNVIDINDYPVPEIEKANRRHRPIGLGVMGLADALAKL 424
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 419 RYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW--NVTPTDLWDWKVLKEKIAKYGI 496
Cdd:COG0209 425 GIPYDSEEARELADEIMEFINYYAYKASAELAKERGAFPAFEGSKYAKGILPFDKYldDLLIPTTLDWDALREDIKKHGL 504
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 497 RNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLS-GEFQIVNPHLLKDLTERGLWHEEMKNQIIAcNGSIQSIPEI 575
Cdd:COG0209 505 RNSTLTAIAPTGTISLIAGTTSGIEPIFSLVYVRKVLDgGEFTVVNPYLVRALKELGLWDEELVEKIKE-DGSVQDIDEL 583
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 576 PDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPIQFT 654
Cdd:COG0209 584 PEELKELYVTAYEIDPEWHIDMQAARQKHVDQAISKTLNLPnDATVEDLAELYLLAWKLGLKG-IYYYRDGSRTGQVLST 662
|
...
gi 968121915 655 LNK 657
Cdd:COG0209 663 GKK 665
|
|
| RNR_I |
cd01679 |
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive ... |
70-644 |
0e+00 |
|
Class I ribonucleotide reductase; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and many viruses, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophages, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class I RNR is oxygen-dependent and can be subdivided into classes Ia (eukaryotes, prokaryotes, viruses and phages) and Ib (which is found in prokaryotes only). It is a tetrameric enzyme of two alpha and two beta subunits; this model covers the major part of the alpha or large subunit, called R1 in class Ia and R1E in class Ib.
Pssm-ID: 153088 [Multi-domain] Cd Length: 460 Bit Score: 773.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 70 PQHMLMRVSVGIHKEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAG 149
Cdd:cd01679 1 PQDRLMRVALGLASGDLEWAKEFYDLLSKQRFTPATPTLFNAGTPRGQLSSCFLLTV-DDSLESIYDTIKECAQLSKIGG 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 150 GIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRAR 229
Cdd:cd01679 80 GIGLNLSNIRATGSPIRGTNGASNGVIPFLKLLNDTARYVDQGG-QRKGAGAVYLEIWHPDIEEFLDLKKNNGDERRRAR 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 230 DLFFALWIPDLFMKRVEtnqdwslmcpnecpgldevwgeefeklyasyekqgrvrkvvkaQQLWYAIIESQTETGTPYML 309
Cdd:cd01679 159 DLFYGVWIPDLFMERVE-------------------------------------------RDLWRKILESQFETGYPYIL 195
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 310 YKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSK-----DEVAVCNLASLALNMYVTsehtydFKKLAEVTKVVVRNLNKII 384
Cdd:cd01679 196 FKDTCNRKNPQKHLGTIKSSNLCTEILQPTSPsedepGEDAVCNLASINLGNFVT------FEKLEEVVKLAVRALDNVI 269
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 385 DINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGpyetyegspv 464
Cdd:cd01679 270 DLNYYPVPEAKRSNMRHRAIGLGVMGLHDYLALLRIPYESEEALDLNDRIFETINYYALKASCELAKERG---------- 339
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 465 skgilqydmwnvtptdlwdwkvlkekiakyGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHL 544
Cdd:cd01679 340 ------------------------------GLRNSLLLAIAPTASISQILGATPSIEPITSNIYVRRVLSGEFPVVNPHL 389
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 545 LKDLTERGlwheemknqiiacngsiqsipeipddlkqLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP-NYGKL 623
Cdd:cd01679 390 EKDLWEYG-----------------------------LYKTAYEIDQRWLIDLAADRQKHIDQGQSLNLFLTPPaTTRDL 440
|
570 580
....*....|....*....|.
gi 968121915 624 TSMHFYGWKQGLKTGmYYLRT 644
Cdd:cd01679 441 NSLYFYAWKKGLKTL-YYLRT 460
|
|
| Ribonuc_red_lgC |
pfam02867 |
Ribonucleotide reductase, barrel domain; |
119-641 |
0e+00 |
|
Ribonucleotide reductase, barrel domain;
Pssm-ID: 460729 [Multi-domain] Cd Length: 487 Bit Score: 754.04 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 119 SSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPG 198
Cdd:pfam02867 1 SSCFLLSV-EDSLDSIYDTLKEAALLSKGGGGIGLNLSKLRAKGSPIRGTGGASSGVVPFLKLFDDSARYVNQGG-KRRG 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 199 AFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKL-YASY 277
Cdd:pfam02867 79 AAAVYLEVWHPDIEEFLDLKKNNGDEEVRARNLNLGVWVPDLFMERVEADEDWTLFSPREAPDLEDLYGEEFEKEyYERE 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 278 EKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMY 357
Cdd:pfam02867 159 ENEGIRKKTVKARELWFKIAKSQIETGYPYILFKDAVNRKNPQKHLGTIKSSNLCTEIVQPTSPSEIAVCNLASINLAKF 238
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 358 VTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFET 437
Cdd:pfam02867 239 VEFGGTFDFEKLREVVKLAVRALDNVIDINDYPVPEARRSNKRHRPIGLGVMGLADALAKLGIPYDSEEARDLNDKIFET 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 438 IYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTD------LWDWKVLKEKIAKYGIRNSLLIAPMPTASTA 511
Cdd:pfam02867 319 MYYYALKASSELAKEKGPFPGFEGSKYSKGILQFDKYVKTDFApkasktREDWEELREDIKKYGLRNSQLTAIAPTGSIS 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 512 QILGNNESIEPYTSNIYTRRVLSgefqivnphllkdlterglwheemknqiiacngsiqsipeipDDLKQLYKTVWEISQ 591
Cdd:pfam02867 399 QIAGATESIEPIFSNVYSRKVLS------------------------------------------EETKEYYKTAYDIDQ 436
|
490 500 510 520 530
....*....|....*....|....*....|....*....|....*....|.
gi 968121915 592 KTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTGMYY 641
Cdd:pfam02867 437 KAHIDMAAARQPFVDQSISKTLFLpNDATTSDLKSLYLYAWKLGLKTIYYY 487
|
|
| NrdE_NrdA |
TIGR02506 |
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) ... |
48-645 |
0e+00 |
|
ribonucleoside-diphosphate reductase, alpha subunit; This model represents the alpha (large) chain of the class I ribonucleotide reductase (RNR). RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. Class I RNR's generate the required radical (on tyrosine) via a "non-heme" iron cofactor which resides in the beta (small) subunit. The alpha subunit contains the catalytic and allosteric regulatory sites. The mechanism of this enzyme requires molecular oxygen. E. Coli contains two versions of this enzyme which are regulated independently (NrdAB and NrdEF, where NrdA and NrdE are the large chains). Most organisms contain only one, but the application of the gene symbols NrdA and NrdE are somewhat arbitrary. This model identifies RNR's in diverse clades of bacteria, eukaryotes as well as numerous DNA viruses and phage. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274170 [Multi-domain] Cd Length: 617 Bit Score: 745.74 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 48 YFGFKTLERSYLLKIN--GKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSERWFTHASPTLFNAGTNRPQLSS 120
Cdd:TIGR02506 1 YMGLKELYNRYLLRNAatGAIYESPQEAYMRVAMGLAslepkDTRLADAIRFYDLLSRLKISPATPTLFNAGTPRGQLSS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 121 CFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAF 200
Cdd:TIGR02506 81 CFLLDVTDDTLESIYKAIDDVAQLSKHGGGIGLNLTKLRAIGSPIRGTNNASKGIIPFLKLLDSSVEAVNQGG-KRPGAA 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 201 AIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQ 280
Cdd:TIGR02506 160 AVYLEVWHPDIEEFLDLKKNNGDERRRCDNLFYGLWIPDLFMKRVEEDKDWYLFSPYDVPGLYGLYGEEFEEEYERLEKD 239
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 281 GRVRK---VVKAQQLWYAIIESQTETGTPYMLYKDSCNRK-SNQQNLGTIKCSNLCTEIVEYTSKD---EVAVCNLASLA 353
Cdd:TIGR02506 240 VEARKkirKVSARDLMKDILRTRVETGRPYILFKDAVNKHnPFKTGGGAIKMSNLCTEITQPTDDShkgETAVCNLASVN 319
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 354 LNMYVTSEhTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQ 433
Cdd:TIGR02506 320 LANFVMED-KFDFSELEDAVRIAVRFLDNVIDLQNYPTAPAAKSNQRRRSIGIGVMGLHDVLAKLGLPYDSEEARDLNDR 398
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 434 IFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLW-------DWKVLKEKIAKYGIRNSLLIAPMP 506
Cdd:TIGR02506 399 IFEAIYYYAIKASAELAKEKGPFPGFSGSKYAKGWLHPDTWEKTIDPKTsmapteeDWEALRERIKEYGLRNSQLTALMP 478
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 507 TASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTV 586
Cdd:TIGR02506 479 TASSSQLTGVTESIEPVFSNIFTKKTLSGEFLIPNKYLMKELEELGLWDADRRGDIVENVGSPQPIAAIPETLKYKYKTA 558
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 587 WEISQKTVLKMAAERGAFIDQSQSLNIHIAE-PNYGKLTSMHFYGWKQGLKTgMYYLRTR 645
Cdd:TIGR02506 559 YELDQEALIDMAADRQKFVDQSISLNLFLTEeVTAKDLLKLLLLAWKKGLKT-MYYCRSR 617
|
|
| PRK07207 |
PRK07207 |
ribonucleoside-diphosphate reductase subunit alpha; |
24-693 |
0e+00 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 235966 [Multi-domain] Cd Length: 965 Bit Score: 655.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 24 LDIVLANKD--RLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDA---AIETYNLLSE 98
Cdd:PRK07207 272 LDPKLAQFDleRLGAALDPERDLQFTYLGLQTLYDRYFLHVDGTRIELPQAFFMRVAMGLALNEIDRearAIEFYNLLSS 351
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 99 RWFTHASPTLFNAGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPM 178
Cdd:PRK07207 352 FDFMSSTPTLFNSGTLRPQLSSCYLTTVPDD-LDGIYEAIKDNALLSKFAGGLGNDWTPVRALGSHIKGTNGKSQGVVPF 430
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 179 LRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNE 258
Cdd:PRK07207 431 LKVVNDTAVAVNQGG-KRKGAVCAYLETWHLDIEEFLELRKNTGDDRRRTHDMNTANWIPDLFMKRVMEDGEWTLFSPSE 509
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 259 CPGLDEVWGEEFEKLYASYEKQG-----RVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCT 333
Cdd:PRK07207 510 VPDLHDLFGKAFEEAYTAYEAKAargeiKLFKKIPAVDLWRKMLSMLFETGHPWITFKDPCNLRSPQQHVGVVHSSNLCT 589
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 334 EIVEYTSKDEVAVCNLASLALNMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLAD 413
Cdd:PRK07207 590 EITLNTSDDEIAVCNLGSVNLVAHIKDGAKLDHEKLKRTVSTAMRMLDNVIDINYYAVPKARNSNLRHRPVGLGIMGFQD 669
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 414 AFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYD-----------MWNVTPTDLW 482
Cdd:PRK07207 670 ALYLLRIPYASDEAVEFADRSMEAVSYYAIWASTELAEERGRYSSYEGSLWSRGILPIDslkllaearggYLEVDRSSTL 749
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 483 DWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQI 562
Cdd:PRK07207 750 DWDALRARIKKHGMRNSNCMAIAPTATISNIIGVSQSIEPTYQNLYVKSNLSGEFTVVNPYLVRDLKARGLWDEVMVNDL 829
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 563 IACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYL 642
Cdd:PRK07207 830 KYFDGSLQRIDRIPADLKALYATAFEVDPRWLVEAASRRQKWIDQAQSLNLYMAGASGKKLDETYKLAWLRGLKT-TYYL 908
|
650 660 670 680 690
....*....|....*....|....*....|....*....|....*....|....*..
gi 968121915 643 RTRPAANPIQFTLNKEKL------KDKEKVSKEEEEKERNTAAMVCSLENRDeCLMC 693
Cdd:PRK07207 909 RTLGATHVEKSTVNTGALnavssgGGGAGGAAAAAAAPPAADPKACSIDDPD-CEAC 964
|
|
| PRK12365 |
PRK12365 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-647 |
5.30e-180 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 171440 [Multi-domain] Cd Length: 1046 Bit Score: 540.30 E-value: 5.30e-180
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIH-KEDIDA---AIETYNLLSERWFTHASPT 107
Cdd:PRK12365 364 DALAEALDLSRDLQFSYMGVQNLYDRYFNHHEGRRLETPQIFWMRVSMGLAlNEGQDKtswAITFYNLLSTFRYTPATPT 443
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 108 LFNAGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTAR 187
Cdd:PRK12365 444 LFNSGMRHSQLSSCYLSTVQDD-LVHIYKVISDNAMLSKWAGGIGNDWTAVRATGALIKGTNGKSQGVIPFIKVANDTAV 522
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 188 YVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWG 267
Cdd:PRK12365 523 AVNQGG-KRKGAVCVYLEVWHLDYEDFLELRKNTGDERRRTHDINTASWIPDLFFKRLQQKGTWTLFSPDDVPGLHEAYG 601
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 268 EEFEKLYASYEKQ---GRVR--KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKD 342
Cdd:PRK12365 602 EEFEKLYEEYERKvdtGEIRlyKKVEAEDLWRKMLSMLYETGHPWMTFKDPSNIRSAQDHKGVVRCSNLCTEILLNCSET 681
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 343 EVAVCNLASLALNMYVTSEHTyDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF 422
Cdd:PRK12365 682 ETAVCNLGSINLVEHIVNDGL-DEEKLSETISIAIRILDNVIDINFYPTKEAKEANLAHRAIGLGVMGFQDALYKLNISY 760
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 423 ESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWN------------VTPTDLWDWKVLKEK 490
Cdd:PRK12365 761 ASQEAVEFADYSSELIAYYAILASSLLAKERGTYSSYKGSKWDRGYLPIDTIEllkeyrgeanllMDTSSRKDWEPVRSL 840
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 491 IAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQ 570
Cdd:PRK12365 841 IKEYGMRNSQLMAIAPTATISNIIGVTQSIEPTYKHLFVKSNLSGEFTIPNVYLIEKLKKLGIWDADMLDDLKYFDGSLL 920
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 968121915 571 SIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPA 647
Cdd:PRK12365 921 EIERIPDHLKKIFLTAFEIEPEWIIECASRRQKWIDMGQSLNLYLAEPDGKKLSNMYLTAWKKGLKT-TYYLRSSAA 996
|
|
| PRK06539 |
PRK06539 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-659 |
2.02e-157 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180610 [Multi-domain] Cd Length: 822 Bit Score: 475.18 E-value: 2.02e-157
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLLKI-NGKVAERPQHMLMRVSVGI---HKEDIDAAIETYNLLSERWFTHASPT 107
Cdd:PRK06539 134 ERLAAALDPTRDELLKYIGVVTLNNRYGIRArNGDALEVPQYFWMRIAMGLslnEDDPTSSALAFYEKMSKLEYLAAGST 213
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 108 LFNAGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTAR 187
Cdd:PRK06539 214 LVNAGTPYPQLSNCFVMEMQDD-IEHIAKTTRDVMWLTKGTGGIGLSVSKLRAQGSPIRSNNTTSTGPIPFMHTIDSVLR 292
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 188 YVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWG 267
Cdd:PRK06539 293 AVSRGG-KKFGALCFYMENWHMDFPEFLDLRQNSGDPYRRTRTANTAVWISDEFMKRVQNDEDWYLFDPLETPDLNELYG 371
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 268 EEFEKLYASYEKQ---GRVR--KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKD 342
Cdd:PRK06539 372 KAFSKRYAQYVEQaeaGRIRmfKRITAREQFRAILMSLQTTSHPWLTWKDTINNRALNNNTGTIHLSNLCTEICLPQDRD 451
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 343 EVAVCNLASLALNMYVTSEHTyDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF 422
Cdd:PRK06539 452 NVSVCNLASINLSRHLADGEL-DWAQLEESTRLAVRQLDNLIDITASSVKEADFSNQQNRAIGLGVMGFTDMVERLGYSY 530
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 423 ESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----------NVTPTDLWDWKVLKEKI 491
Cdd:PRK06539 531 ESEEAYDLIDRIMEHISYAAIDESADLAAERGAYPNFEGSRWSRGMVPVDSIalleadrgvpvDVNRTTRLDWDALRAKV 610
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 492 aKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWhEEMKNQIIACNGSIQS 571
Cdd:PRK06539 611 -RGGMRNATLMAIAPTASIGLVAGTTPGLDPQFSQIFSRSTSSGKFLEVNRNLVADLKELGLW-ETVREEILRSQGDIQE 688
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 572 IPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAANPI 651
Cdd:PRK06539 689 IAAIPDEIKALYRTSFQLSPYAFLEVAARAQKWVDQAISRNMYLESRDIGDMMDIYTAAWEMGVKT-TYYLHMKPRHTAE 767
|
....*...
gi 968121915 652 QFTLNKEK 659
Cdd:PRK06539 768 QSTVKVNK 775
|
|
| PRK08447 |
PRK08447 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-644 |
7.05e-149 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236266 [Multi-domain] Cd Length: 789 Bit Score: 452.26 E-value: 7.05e-149
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIHKEDIDA---AIETYNLLSERWFTHASPT 107
Cdd:PRK08447 123 DDLNAYIKPERDLQFNYLGIKTLYDRYLIKdRNNNPIELPQHMFMAIAMFLAQNELDPqkwAKKFYDVISKFEVMLATPT 202
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 108 LFNAGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTAR 187
Cdd:PRK08447 203 LSNARTTRHQLSSCYIGSTPDN-IEGIFDSYKEMALLSKYGGGIGWDWSKVRAMGSYIDGHKNAAGGIIPFLKITNDIAI 281
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 188 YVDQGGNkRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWG 267
Cdd:PRK08447 282 AVDQLGT-RKGAIAVYLEPWHMDISDFIDLRKNSGEERRRAHDLFPALWINDLFMKRVEEDAMWTLFDPYECKDLTELYG 360
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 268 EEFEKLYASYEKQGRVRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI----------- 335
Cdd:PRK08447 361 EEFEKRYLEYEKDEKIIKeYINAKELWKKILTNYFETGLPFLCFKDNANRANPNAHAGIIRSSNLCTEIfqntapnhyki 440
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 336 -VEYTSKDEV--------------------------------------------AVCNLASLALNMYVTSEhtydfkKLA 370
Cdd:PRK08447 441 kIEFEDGSIEffeeeelvtvdsgitkkakkitsldslkgkkiyivekekkdgktAVCNLASINLSKINTKE------DIE 514
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 371 EVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLA 450
Cdd:PRK08447 515 RVVPIAIRMLDNVIDLNFYPNRKVKATNLKSRAIGLGVMGEAQMLAEHKIAWGSKEHLEKIDEIMEQISYNAIDASSNLA 594
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 451 KEQGPYETYEGSPVSKGILQYDMWN------VTPTDLW----DWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESI 520
Cdd:PRK08447 595 LEKGVYPDFEGSNWSKGIFPIDKANeeakklVERGGLFdsacDWEGLREKVKKDGMRNGYLMAIAPTSSISILVGTTQTI 674
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 521 EPytsnIYTRRvlsgefqivnphllkdlterglWHEEMKNQIIACngsiqSIPEIPDDLKQLYKTVWEISQKTVLKMAAE 600
Cdd:PRK08447 675 EP----VYKRK----------------------WFEENLSGLIPV-----VVPNLSPETWQYYTPAYDLDQKDLIKAAAV 723
|
650 660 670 680
....*....|....*....|....*....|....*....|....*.
gi 968121915 601 RGAFIDQSQSLNIHIA-EPNYGK-LTSMHFYGWKQGLKTgMYYLRT 644
Cdd:PRK08447 724 RQKWIDQGQSLNIFLSlDKASGKyLNEIYTLAWKLGLKS-TYYLRS 768
|
|
| PRK09209 |
PRK09209 |
ribonucleoside-diphosphate reductase subunit alpha; |
31-645 |
3.03e-132 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181700 [Multi-domain] Cd Length: 761 Bit Score: 407.96 E-value: 3.03e-132
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 31 KDRLNSA---IIYDRDFSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGI-HKEDIDAAI----ETYNLLSERWF 101
Cdd:PRK09209 138 KEELIEAgkmIDPERDKLFTYIGLYLLADRYLATdSDRNVYELPQERWLTIALYLmQNEPRERRMqlvkEAYWALSNLYM 217
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 102 THASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRV 181
Cdd:PRK09209 218 TVATPTLANAGKVGGQLSSCFIDTV-DDSLQGIYDSNTDVARVSKHGGGVGAYLGKVRSRGSDIRGFKGVSSGVIPWIKQ 296
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 182 YNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECP- 260
Cdd:PRK09209 297 LNNTAVSVDQLG-QRKGAIAVYLDVWHKDIESFLDLRLNNGDERLRAHDVFTGVCIPDLFMEAVERRGDWYLFDPHEVKk 375
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 261 ----GLDEVWGEE-----FEKLYASYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSN 330
Cdd:PRK09209 376 vmgwYLEDFYDEKkgdgsFREKYEECVADERLsRKTVKAIDIMKRIMVSQLETGNPFMFYRDEVNRMNPNKHEGMIYSSN 455
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 331 LCTEIV----------EYTSKDEV---------AVCNLASLALNMYVTSEhtydfkKLAEVTKVVVRNLNKIIDINYYPV 391
Cdd:PRK09209 456 LCTEIMqnmsptvmiqEIISGGQIvitkqpgdfVVCNLSSINLGRAVTAD------VLERLIPIQVRMLDNVIDLNQLPV 529
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 392 PEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilQY 471
Cdd:PRK09209 530 PQATITNQKYRAIGLGTFGWHHLLALKGIAWESEEAVQYADELYERINYLTIQASMELAKEKGAYPVFKGSDWQTG--EY 607
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 472 -DMWNVTPTdlwDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPhllkDLTE 550
Cdd:PRK09209 608 fERRGYNSP---QWDELAAQVAENGVRNAYLMAVAPNMSTAQIAGSTASIDPIYSAFYYEEKKDYRRPVTAP----DLSL 680
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 551 RGLWHEEmknqiiacngsiqsipeipddlkqlyKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIaePN---YGKLTSMH 627
Cdd:PRK09209 681 DTWPYYE--------------------------KGAYKVDQFWSIRQNAARQRHVDQSISFNFYV--PStirASELLDLH 732
|
650
....*....|....*...
gi 968121915 628 FYGWKQGLKTgMYYLRTR 645
Cdd:PRK09209 733 MTAWKEGLKT-TYYVRST 749
|
|
| PRK09102 |
PRK09102 |
ribonucleoside-diphosphate reductase subunit alpha; |
29-648 |
3.08e-126 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 236378 [Multi-domain] Cd Length: 601 Bit Score: 387.39 E-value: 3.08e-126
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 29 ANKDRLNSAIIYDRDFSYNYFGFKTLERSYLLKingkvAERPQHMLMRVSVgiHKEDIDAAIET--YNLLSERWFTHASP 106
Cdd:PRK09102 4 QNKLVFQINIDRSRDAWLTEFGKATLRDRYLLE-----GESYQDLFARIAE--AYADIDPEHAQrfYDYMSRGWFMPATP 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 107 TLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIaGTNGNSNGLVPMLRVYNNTA 186
Cdd:PRK09102 77 VLSNGGTDRGLPISCFLNYV-EDSLEGIVNTWNENVWLAKRGGGIGSYWGNVRSIGEPI-RNNGKSSGIIPFIKVMDSLT 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 187 RYVDQGGNKRpGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPnecpgldevw 266
Cdd:PRK09102 155 LAISQGSLRR-GSFAVYLDIEHPEIEEFLDIRKPTGDPNRKALNLHHGVCVTDEFMEAVEDGDEWDLISP---------- 223
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 267 geefeklyasyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRK--SNQQNLG-TIKCSNLCTEI-----VEY 338
Cdd:PRK09102 224 ------------KDKSVIRTVKARDLWAKILETRIETGEPYLLFIDNVNRAlpEVYKDLGlKVKASNLCSEItlptgIDH 291
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 339 TSKDEVAVCNLASLALNMYVTSEHTYDFkklaevTKVVVRNLNKIID--INYYP--VPEACLSNKRHRPIGIGVQGLADA 414
Cdd:PRK09102 292 LGEDRTAVCCLSSLNLEYYDEWKDTDAF------IEDLMRFLDNVLQdfIDKAPdeMERAKYSAMRERSVGLGVMGFHSY 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 415 FILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPyetyegspvskgilqydmwnvtPTDLwdwkvlkekiAKY 494
Cdd:PRK09102 366 LQSKMIPFESVMAKQWNKKIFKHIREQADKASKELAKEKGE----------------------CPDA----------AGY 413
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 495 GI--RNSLLIAPMPTASTAQILGN-NESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEEMKNQIIACNGSIQS 571
Cdd:PRK09102 414 GVmrRFSTKMAIAPTASISIILGNtSPGIEPIAANYYTHKTLKGSFTVKNKYLEKLLEEKGKDTDEVWSSILTNEGSVQH 493
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 968121915 572 IPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI-AEPNYGKLTSMHFYGWKQGLKTgMYYLRTRPAA 648
Cdd:PRK09102 494 LDFLSEEEKDVFKTAFEIDQRWIIELAADRQKYIDQAQSLNLFLpANVPKRDLNKLHFEAWKKGVKS-LYYQRSKSVQ 570
|
|
| PRK07088 |
PRK07088 |
ribonucleoside-diphosphate reductase subunit alpha; |
34-645 |
4.67e-124 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 180831 [Multi-domain] Cd Length: 764 Bit Score: 386.86 E-value: 4.67e-124
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 34 LNSAIIYDRDFSYNYFGFKTLERSYLLK-INGKVAERPQHMLMRVSVGIHKEDIDA-----AIETYNLLSERWFTHASPT 107
Cdd:PRK07088 146 LEKYIKPERDFLFNYEGLKLLADRYLVKgFNREILELPQERFMGIAMHLAIPEGKEkrvyyAKKFYDLLSELKATVATPT 225
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 108 LFNAGTNRPQLSSCFLlSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTAR 187
Cdd:PRK07088 226 LSNAGTPFYQLSSCFI-SVVDDNLWSIYDVNQKFAQVSKHGGALGIYTGKIRALNSEIRGFKNASGGVIPWIKLYNDTAI 304
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 188 YVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPGL----- 262
Cdd:PRK07088 305 AVDQLG-KRKGGAAITLDIWHKDIPEFLDLKTNNGDDRRKAHDIFPGVSYPDLFMKRLEKRENWSLFDPHEIKKVkgysl 383
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 263 ----DEVWGEEFEKLYASYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVE 337
Cdd:PRK07088 384 edyyDEEDRKEFTKKYLECEEDTNIpRRTVPVLDIMKKIMKSAVETGTPFIFFRDTVNKANPNKHKGMIYSSNLCHEIAQ 463
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 338 YTSKDEVA-----------------------VCNLASLALNmyvtsehTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEA 394
Cdd:PRK07088 464 NMSESELLeeeiidengyyevvqkikagdmvTCNLNSIVLG-------NVDDEELEEVIPTQIRMLDNVISLNYYPVPEA 536
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 395 CLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGilqyDMW 474
Cdd:PRK07088 537 EITSDKYRAIGLGTSGYHHMLANNKIRWESDEHIKFADKIYEEIAYYAIKASMELAKEKGSYPAFKGSEWETG----KYF 612
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 475 NVTPTDLWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsnIYTRrvlsgefqivnphllkdltergLW 554
Cdd:PRK07088 613 ERRGYNSERWKKLKEEIKKYGMRNGYITAVAPTGSTSNIANTTAGIDP----VFKR----------------------FF 666
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 555 HEEMKnqiiacnGSIqsIPEIPDDLKQ----LYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAePNYGKLTSMHFY- 629
Cdd:PRK07088 667 MEEKK-------GSF--TPKTAPDLNEenfwYYKEAHTIDQQWSIKACGVRQRHIDQAQSFNLYIT-PEYKAKQILNLYi 736
|
650
....*....|....*..
gi 968121915 630 -GWKQGLKTgMYYLRTR 645
Cdd:PRK07088 737 eAWKQGVKT-IYYVRNK 752
|
|
| PRK12364 |
PRK12364 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-645 |
5.84e-123 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 237077 [Multi-domain] Cd Length: 842 Bit Score: 386.41 E-value: 5.84e-123
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLLKI-NGKVAERPQHMLMrvSVGIH------KEDIDAAIETYNLLSERWFTHA 104
Cdd:PRK12364 222 EEAAGFIDPERDKLFTYSGLDLLLKRYVIRThSHEPLESPQEMFL--GIALHlampekQDRMGWVKRFYDMLSKLKVTMA 299
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 105 SPTLFNAGTNRPQLSSCFLLSMKDdSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNN 184
Cdd:PRK12364 300 TPTLSNARKPFHQLSSCFIDTVPD-SLDGIYRSIDNFAQVSKFGGGMGLYFGKVRAVGSNIRGFQGVAGGVIRWIKLAND 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 185 TARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVE--TNQDWSLMCPNECP-- 260
Cdd:PRK12364 379 TAVAVDQLG-MRQGAVAVYLDVWHKDIPEFLQLRTNNGDDRMKAHDVFPAVCYPDLFWKMVRddINQSWYLFCPHEILtv 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 261 ---GLDEVWGEEFEKLYASYEKQGRV-RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI- 335
Cdd:PRK12364 458 kgyALEDYYGEEWEKRYLDCVNDARIsKRSIPIKDLVRLILKSAVETGTPFTFNRDTVNRANPNKHKGMIYCSNLCTEIa 537
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 336 ----------------------VEYTSKDEVAVCNLASLAL-NMYVTSEHtydfkKLAEVTKVVVRNLNKIIDINYYPVP 392
Cdd:PRK12364 538 qnmsaietvsteietedgdtvvVTTTRPGDFVVCNLASLSLgNIDLEDEE-----ELEEVVRTVVRALDNVIDLNFYPVP 612
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 393 EACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILqYD 472
Cdd:PRK12364 613 YAQITNKRYRSIGLGVSGYHHALAKNGIRWESEEHLEFADRVFERINYAAIKASMEIAKEKGAYGYFEGSDWQTGAY-FR 691
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 473 MWNVTPTdlwDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsniytrrvlsgefqIVNPHLLkdlterg 552
Cdd:PRK12364 692 KRGYTSE---EWQRLAREVAENGMRNAYLLAVAPTSSTSIIAGTTAGVDP----------------VMKRYFL------- 745
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 553 lwhEEMKNQIIAcngsiQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIA-EPNYGKLTSMHFYGW 631
Cdd:PRK12364 746 ---EEKKGALMP-----RVAPELSDKTFWLYKNAHLIDQKWSIRAAGVRQRHIDQAQSVNLYITnEFTMRQVLDLYLLAW 817
|
650
....*....|....
gi 968121915 632 KQGLKTgMYYLRTR 645
Cdd:PRK12364 818 EEGVKT-IYYVRSK 830
|
|
| NrdJ_Z |
TIGR02504 |
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a ... |
54-636 |
5.26e-101 |
|
ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent; This model represents a group of adenosylcobalamin(B12)-dependent ribonucleotide reductases (Class II RNRs) related to the characterized species from Pyrococcus, Thermoplasma, Corynebacterium, and Deinococcus. RNR's are responsible for the conversion of the ribose sugar of RNA into the deoxyribose sugar of DNA. This is the rate-limiting step of DNA biosynthesis. This model identifies genes in a wide range of deeply branching bacteria. All are structurally related to the class I (non-heme iron dependent) RNRs. In most species this gene is known as NrdJ, while in mycobacteria it is called NrdZ. [Purines, pyrimidines, nucleosides, and nucleotides, 2'-Deoxyribonucleotide metabolism]
Pssm-ID: 274168 [Multi-domain] Cd Length: 575 Bit Score: 320.81 E-value: 5.26e-101
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 54 LERSYLLKI-NGKVAERPQHMLMRVSVGI-HKEDIDA-------AIETYNLLSERWFTHASPTLFN-AGTNRPQLSSCFL 123
Cdd:TIGR02504 2 LAARYLLKDeDGNIIESPEDLFRRVARALaAAEDKYNspvwkqwYERFYDLMVNLGFIPNSPTLMNaGGTRLGQLSACFV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 124 LSMKDDSiEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIY 203
Cdd:TIGR02504 82 LPVEDSM-EDIFEALKEAALIFKRGGGVGYNFSTLRPKGDLVSGTGGVASGPVSFMRVFDSAAGVVKQGG-TRRGAQMGI 159
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 204 LEPWHLDIFEFLDLKKNTGKEEQrardlF-FALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqgR 282
Cdd:TIGR02504 160 LDVWHPDIEEFIEAKAKEGKLQN-----FnISVGVTDEFMEAVENDEEYELRNPRT-----------------------G 211
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 283 VRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEI--VEYTSkdevavCNLASLALNMYV-- 358
Cdd:TIGR02504 212 EYKEVDARELWDKIVESAWKSAEPGVLFIDTINKWHTCPYGGRINATNPCGEQplLPYES------CNLGSINLAKFVkn 285
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 359 --TSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFE 436
Cdd:TIGR02504 286 dfGDEASFDFERLREVVRLATRFLDNVIDINVFPLPEIAENTKKTRRIGLGIMGLADLLIKLGIPYDSEEARELAEEVME 365
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 437 TIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVT-PTDLWDWkvlkekIAKYGIRNSLLIAPMPTASTAQILG 515
Cdd:TIGR02504 366 FIADAAYRASAELAKERGAFPLYDASKYPMGRAMGARIPSAlPAEIREA------IRKYGIRNAQLTTIAPTGTISLIAG 439
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 516 NNESIEPYTSNIYTRRVL-SGEFQIVNPHLLKDLTERGLWHEEmKNQIIACNGSIQSIPEiPDDLKQLYKTVWEISQKTV 594
Cdd:TIGR02504 440 TSSGIEPVFALVYFRNVTvGGELLEVNPLVELALRELGYYSDE-IVKYVDEKGTVEGAPG-PEELPKVFVTAMDISPEDH 517
|
570 580 590 600 610
....*....|....*....|....*....|....*....|....*....|..
gi 968121915 595 LKMAAERGAFIDQSQSLNIHIaePN----------YgkltsmhFYGWKQGLK 636
Cdd:TIGR02504 518 VLMQAAIQPWVDSSISKTINM--PSdatvedvkavY-------LEAWKLGLK 560
|
|
| RNR_II_dimer |
cd02888 |
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the ... |
91-523 |
2.40e-100 |
|
Class II ribonucleotide reductase, dimeric form; Ribonucleotide reductase (RNR) catalyzes the reductive synthesis of deoxyribonucleotides from their corresponding ribonucleotides. It provides the precursors necessary for DNA synthesis. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs, found in eukaryotes, bacteria, and bacteriophage, use a diiron-tyrosyl radical. Class II RNRs, found in bacteria, bacteriophage, algae and archaea, use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs, found in anaerobic bacteria, bacteriophage, and archaea, use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. Many organisms have more than one class of RNR present in their genomes. All three RNRs have a ten-stranded alpha-beta barrel domain that is structurally similar to the domain of PFL (pyruvate formate lyase). Class II RNRs are found in bacteria that can live under both aerobic and anaerobic conditions. Many, but not all members of this class are found to be homodimers. Adenosylcobalamin interacts directly with an active site cysteine to form the reactive cysteine radical.
Pssm-ID: 153089 [Multi-domain] Cd Length: 464 Bit Score: 315.71 E-value: 2.40e-100
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 91 ETYNLLSERWFTHASPTLFNAGTN-RPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTN 169
Cdd:cd02888 3 EFFYLLLSQGFIPNSPTLMNAGTGeLGQLSACFVLPVEDDSIEGIFDALKEAALIFKRGGGVGYNFSRLRPKGDIVKSTG 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 170 GNSNGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKntgKEEQRARDLFFAL--WIPDLFMKRVET 247
Cdd:cd02888 83 GVASGPVSFMRVFDAATGVIKQGG-TRRGANMGVLDVDHPDIEEFIDAKM---KEEKTVVLQNFNIsvAVTDAFMEAVEN 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 248 NQDWSLMCPNECPGldevwgeefeklyasyekqGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIK 327
Cdd:cd02888 159 DEPWELRNPREPDT-------------------GKVYRTVPARELWDKIVEAAWDSADPGVLFIDTINRWNPLPGLGRIN 219
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 328 CSNLCTEIV--EYTSkdevavCNLASLALNMYV---TSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHR 402
Cdd:cd02888 220 ATNPCGEQPllPYES------CNLGSINLSKFVknpFGGASFDFERLREAVRLAVRFLDNVIDVNRYPLPEIAEETKATR 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 403 PIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSpvskgilQYDMWNVTPTDLW 482
Cdd:cd02888 294 RIGLGVMGLADMLIKLGIPYDSEEARELAERIMSFIRDAAYRASAELAKERGPFPLFDAS-------RYLMLKVIVNAKE 366
|
410 420 430 440
....*....|....*....|....*....|....*....|.
gi 968121915 483 DWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPY 523
Cdd:cd02888 367 LPDDVLEEIEKYGIRNAHLTTIAPTGTISLIAGTSSGIEPI 407
|
|
| nrdA |
PHA02572 |
ribonucleoside-diphosphate reductase subunit alpha; Provisional |
32-659 |
1.21e-91 |
|
ribonucleoside-diphosphate reductase subunit alpha; Provisional
Pssm-ID: 222883 [Multi-domain] Cd Length: 753 Bit Score: 301.25 E-value: 1.21e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLLK--INGKVAERPQHMLMRVSVGIHKED-----IDAAIETYNLLSERWFTha 104
Cdd:PHA02572 127 TYLESFIDHDRDFEFTYAGAMQLKEKYLVQdrSTGEIYETPQFAYMLIAMALHQDEpkedrLEHVIRFYNAVSTRKIS-- 204
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 105 SPTLFNAGTNRP--QLSSCFLLSMkDDSIEGIYDTLKQCA-LISKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPMLRV 181
Cdd:PHA02572 205 LPTPIMAGVRTPtrQFSSCVVIES-GDSLDSINKTAMAIVkYISKRAG-IGINAGMIRAEGSKIRGGEVRHTGVIPFWKH 282
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 182 YNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNECPG 261
Cdd:PHA02572 283 FQTAVKSCSQGG-IRGGAATAYYPIWHLEVEDLLVLKNNKGVEENRIRHLDYGVQINDLMYERFIKNDYITLFSPHDVGG 361
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 262 ldEVWG------EEFEKLYASYEKQGRVR-KVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNqqNLGTIKCSNLCTE 334
Cdd:PHA02572 362 --ELYDayfadqDRFRELYEALEKDPSVRkKRIKAQELFLLLLKERSETGRIYIMFIDHCNNHSP--FKDPIRQSNLCCE 437
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 335 IVEYTS-------KDEVAVCNLASLALNMYVtsehtyDFKKLAEVTKVVVRNLNKIIDINYYPVPEAcLSNKRHRPIGIG 407
Cdd:PHA02572 438 IALPTKplnhidgEGEIALCTLSAIVLGNFE------DQDEIEELAEVAVRALDNLLDYQDYPVPAA-LKAKKRRSLGVG 510
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 408 VQGLAdAFILMRY-PFESAEAQLLNKqIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWN------VTPTD 480
Cdd:PHA02572 511 VTNYA-HYLAKNFaSYEDANADLVHE-LFERLQYYLIKASNKLAKEKGACEYFSDTKYSRGELPIDWYKkkvdelVAPKY 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 481 LWDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFqivnphllkdlterglwheemkN 560
Cdd:PHA02572 589 NCDWESLREDLKKYGIRNSTLSALMPCESSSQVSNSTNGIEPPRGPVSIKKSKEGPF----------------------N 646
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 561 QIiacngsiqsIPEIpDDLKQLYKTVWEISQKT---VLKMAAERGAFIDQSQSLNIHIAEPNY--GKL-TSMHF----YG 630
Cdd:PHA02572 647 QV---------VPNV-ETLKDLYDLLWDLAKKGnkgYLTQVAIMQKFVDQAISANTSYDPENYpnGKVpMSVMLddllYF 716
|
650 660
....*....|....*....|....*....
gi 968121915 631 WKQGLKTgMYYLRTRPAANPIQFTLNKEK 659
Cdd:PHA02572 717 YYYGGKT-LYYHNTRDGKGTEDYEIETPK 744
|
|
| PRK08665 |
PRK08665 |
vitamin B12-dependent ribonucleotide reductase; |
54-604 |
4.70e-85 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236330 [Multi-domain] Cd Length: 752 Bit Score: 283.75 E-value: 4.70e-85
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 54 LERSYLLK-INGKVAERPQHMLMRVSVGI--------HKEDIDA-AIETYNLLSERWFTHASPTLFNAGTNRPQLSSCFL 123
Cdd:PRK08665 20 LEKRYLKKdEDGKPIETPEDMFRRVARTIaaaeliydSKADVEAlADRFYDLMTSLEFLPNSPTLMNAGRELGQLSACFV 99
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 124 LSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIy 203
Cdd:PRK08665 100 LPV-GDSIEEIFDAVKHAALIHKSGGGTGFSFSRLRPKNDRVGSTGGVASGPVSFMRVFDAATEAIKQGGTRRGANMGI- 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 204 LEPWHLDIFEFLDLKKNTGKeeqrARDLFFALWIPDLFMKRVETNQDWSLMCPNEcpgldevwgeefeklyasyekqGRV 283
Cdd:PRK08665 178 LRVDHPDIMEFITCKEDNGE----LTNFNISVAITEAFMEAVEADEEYDLINPRT----------------------GEV 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 284 RKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVTsE 361
Cdd:PRK08665 232 VGRLNAREVFDLIVEMAWENGEPGIVFIDRINRDNPTPHLGEIESTNPCGEqpLLPYES------CNLGSINLSKMVK-N 304
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 362 HTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYG 441
Cdd:PRK08665 305 GDVDWEKLREVVHLAVRFLDNVIDANKYPLPQIEEMTKGNRKIGLGVMGWADMLIQLGIPYDSEEAVELAEKVMKFIQDE 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 442 ALEASCDLAKEQGPYETYEGSpvskgilqydmwnvtptdLWDwkvlKEKIAKYgiRNSLL--IAPMPTAStaqILGNNES 519
Cdd:PRK08665 385 AHAASRELAEERGPFPNYEGS------------------IYD----KDGLGPM--RNATVttIAPTGTIS---IIAGCSS 437
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 520 -IEPYTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEE-MKNqiIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLK 596
Cdd:PRK08665 438 gIEPLFALSFTRNVMDGERLVeVNPVFEAAAKEEGFYSEElMEK--IAEKGSIQDIDEVPEDVRRVFVTAHDISPEWHVR 515
|
....*...
gi 968121915 597 MAAergAF 604
Cdd:PRK08665 516 MQA---AF 520
|
|
| PRK06406 |
PRK06406 |
vitamin B12-dependent ribonucleotide reductase; |
93-615 |
1.72e-74 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 235796 [Multi-domain] Cd Length: 771 Bit Score: 255.55 E-value: 1.72e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 93 YNLLSERWFTHASPTLFNAGTNRPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGNS 172
Cdd:PRK06406 224 EEVMSNLKFVPNSPTLMNAGTKLGQLSACFVLPV-PDSIEGIFNALKYTAMIHKSGGGTGFSFSRLRPKDDIVASTKGVA 302
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 173 NGLVPMLRVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNtgkEEQRARDLFFALWIPDLFMKRVETNQDWS 252
Cdd:PRK06406 303 SGPLSFMRIFDVTTDVIKQGG-KRRGANMGILSYHHPDIMEFITSKDS---ENKVLSNFNISVAVTDEFFDKLDNDDYYP 378
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 253 LMCPnecpgldevwgeefeklyasyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLC 332
Cdd:PRK06406 379 LRNP----------------------RNGKEVKRIKARQVWDLIITQAWKTGDPGVIFLDEINRKNPVKNLGEIESTNPC 436
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 333 TE--IVEYTSkdevavCNLASLALNMYVTsEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQG 410
Cdd:PRK06406 437 GEqpLLPYES------CNLGSINLSKFVE-NGKIDWDRLRETVHIATRFLDNVIDANKFPVPQIKEMTRMTRKIGLGVMG 509
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 411 LADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSpvskgilqydmwnvtptdlwDWKvlKEK 490
Cdd:PRK06406 510 FADMLIKLGIPYNSEEALEIAEKVMKFINEESHRASQKLAEERGVFPAWYGS--------------------EWE--KKG 567
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 491 IAkygIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQI-VNPHLLKDLTERGLWHEEMKNQiIACNGSI 569
Cdd:PRK06406 568 IK---MRNSTTTTIAPTGTISIIAGCSSSIEPLFAIAFVRHVLNGQELLeVNPLFEEITRKRGLYSEELMRK-VAETGNL 643
|
490 500 510 520
....*....|....*....|....*....|....*....|....*.
gi 968121915 570 QSIpEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHI 615
Cdd:PRK06406 644 QNI-DVPEDIKRIFVTAHEIDPQWHVLMQATFQRYCDSGVSKTINL 688
|
|
| PRK09103 |
PRK09103 |
ribonucleoside-diphosphate reductase subunit alpha; |
32-652 |
4.12e-67 |
|
ribonucleoside-diphosphate reductase subunit alpha;
Pssm-ID: 181649 [Multi-domain] Cd Length: 758 Bit Score: 234.88 E-value: 4.12e-67
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 32 DRLNSAIIYDRDFSYNYFGFKTLERSYLL--KINGKVAERPQHMLMRVSVGI-----HKEDIDAAIETYNLLSErwFTHA 104
Cdd:PRK09103 126 DQMDTFIDHWRDMNFSYAAVKQLEGKYLVqnRVTGEIYESAQFLYILVAACLfsnypKETRLDYVKRFYDAVST--FKIS 203
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 105 SPTLFNAGTNRP--QLSSCFLLSMkDDSIEGIYDTlkQCALI---SKSAGgIGVAVSCIRATGSYIAGTNGNSNGLVPML 179
Cdd:PRK09103 204 LPTPIMSGVRTPtrQFSSCVLIEC-GDSLDSINAT--SSAIVkyvSQRAG-IGINAGRIRALGSPIRGGEAFHTGCIPFY 279
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 180 RVYNNTARYVDQGGnKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRARDLFFALWIPDLFMKRVETNQDWSLMCPNEC 259
Cdd:PRK09103 280 KHFQTAVKSCSQGG-VRGGAATLFYPIWHLEVESLLVLKNNRGVEENRVRHMDYGVQINKLMYQRLIKGGDITLFSPSDV 358
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 260 PGLDEVW---GEEFEKLYASYEKQGRVRK-VVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSN-QQNLGTIKCSNLCTE 334
Cdd:PRK09103 359 PGLYDAFfadQDEFERLYTKYEQDDSIRKkRVKAVELFSLMMQERASTGRIYIQNVDHCNTHSPfDPKVAPVRQSNLCLE 438
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 335 IVEYT--------SKDEVAVCNLASLALNmyvTSEHTYDFKKLAEvtkVVVRNLNKIIDINYYPVPEACLSNKRHRPIGI 406
Cdd:PRK09103 439 IALPTkplndvndENGEIALCTLSAFNLG---AINSLDELEELAD---LAVRALDALLDYQDYPIPAAKRGAMGRRTLGI 512
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 407 GVQGLadAFIL----MRYPFESAEAqlLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMW-----NVT 477
Cdd:PRK09103 513 GVINF--AYYLakngVRYSDGSANN--LTHKTFEAIQYYLLKASNELAKEQGACPWFNETTYAQGILPIDTYkkdldAIC 588
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 478 PTDL-WDWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPytsniytrrvlsgefqivnPhllkdlteRGLWH- 555
Cdd:PRK09103 589 NEPLhYDWETLREEIKTHGLRNSTLSALMPSETSSQISNATNGIEP-------------------P--------RGYVSi 641
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 556 EEMKNQIIAcngsiQSIPEIpDDLKQLYKTVWEI-SQKTVLKMAAERGAFIDQSQSLNIHIaEPN---YGKLTSMHF--- 628
Cdd:PRK09103 642 KASKDGILK-----QVVPDY-ERLKDAYELLWEMpNNDGYLQLVGIMQKFVDQSISANTNY-DPSrfpSGKVPMKQLlkd 714
|
650 660
....*....|....*....|....*.
gi 968121915 629 --YGWKQGLKTgMYYLRTRPAANPIQ 652
Cdd:PRK09103 715 llTAYKFGVKT-LYYHNTRDGAEDAQ 739
|
|
| PRK08115 |
PRK08115 |
vitamin B12-dependent ribonucleotide reductase; |
93-557 |
1.84e-43 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236152 [Multi-domain] Cd Length: 858 Bit Score: 168.10 E-value: 1.84e-43
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 93 YNLLSERWFTHASPTLFNAGTNRP-QLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGTNGN 171
Cdd:PRK08115 160 YQELVNMNFVPAGRVLYGAGSKTDvTYFNCYVMPFVKDSREGISEHRKQVMEIMSRGGGVGTNGSTLRPRNTLARGVNGK 239
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 172 SNGLVPMLRVYNNTARYVDQGGNKRpGAFAIYLEPWHLDIFEFLD-----------LKKNTGKEE--------------- 225
Cdd:PRK08115 240 SSGSVSWLDDIAKLTHLVEQGGSRR-GAQMIMLADWHPDILEFIIskmqnprilryLLENTEDEQikrlvkeklkftpls 318
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 226 ---------------------------QRARDLF-----FALWIPDL-------------FMKRVETNQDWSLMCPN--- 257
Cdd:PRK08115 319 eveeamyqaivnykniegqggfdtkviKEAENKLrtggtYTVNNPEFltganisvcltkeFMEAVENDEEYELRFPDven 398
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 258 ----ECPGLDEVWGE-----EFEKLyaSYEKqgRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLG-TIK 327
Cdd:PRK08115 399 yteeEMEIYNEEWHEvgdvrEWEKM--GYPV--RTYRKIKAKELWNLINICATYSAEPGIFFIDNANEMTNAKAYGqKVV 474
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 328 CSNLCTE--IVEYTskdevaVCNLASLAL-NMYVTSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPI 404
Cdd:PRK08115 475 ATNPCGEqpLAPYS------VCNLAAINLaNMADKETKTVDYEKLKRTVEVGVRMQDNVIDATPYFLEENKKQALGERRV 548
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 405 GIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSP------VSKGILQYDMWNVTP 478
Cdd:PRK08115 549 GLGVMGLHDLLIYCETVYGSEEGNQLVDQIFETIATTAYRTSIELAKEKGSFPFLVGQTeeetakLREAFINTGYMKKMP 628
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 968121915 479 TDlwdwkvLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHEE 557
Cdd:PRK08115 629 ED------IREDILKYGIRNSHLLTVAPTGSTGTMVGVSTGLEPYFSFSYYRSGRLGKFIEVKADIVQEYLDKHPEADE 701
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
329-589 |
2.43e-40 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 159.93 E-value: 2.43e-40
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 329 SNLCTE--IVEYTSkdevavCNLASLALNMYVTSEHT----YDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHR 402
Cdd:PRK08332 1294 SHNCGEepLYEYES------CNLASINLAKFVKYDENgkpyFDWDEYAYVIQKVAKYLDNAIDVNKFPLPEIDYNTKLTR 1367
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 403 PIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGIL------QYDMWNV 476
Cdd:PRK08332 1368 RIGVGMMGLADALFKLGIPYNSEEGFKFMRKVTEYLTFYAYKYSVEAAKKRGTFPLYEKTEYPKGELpvegfyHPEIWNL 1447
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 477 TptdlwdWKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGLWHE 556
Cdd:PRK08332 1448 P------WDKLVEEIKKYGVRNAMVTTCPPTGSVSMIADTSSGIEPIFALVYKKSVTVGEFYYVDPVFEAELKKRGLYSE 1521
|
250 260 270
....*....|....*....|....*....|...
gi 968121915 557 EMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEI 589
Cdd:PRK08332 1522 ELLKKISDNYGSVQGLEEIPEDMQRVFVTALDI 1554
|
|
| PRK06556 |
PRK06556 |
vitamin B12-dependent ribonucleotide reductase; Validated |
80-578 |
2.65e-38 |
|
vitamin B12-dependent ribonucleotide reductase; Validated
Pssm-ID: 235828 [Multi-domain] Cd Length: 953 Bit Score: 152.82 E-value: 2.65e-38
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 80 GIHKEDIDAAI---E-TYNLLSERwFTHASPTLFNAGTN-RPQLSSCFLLSMkDDSIEGIYDTLKQCALISKSAGGIGVA 154
Cdd:PRK06556 107 GYFATEEDAEIfehElTWLLLHQK-FSFNSPVWFNVGTEsPQQVSACFILSV-DDSMESILNWYKEEGMLFKGGSGTGTN 184
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 155 VSCIRATGSYIAGtNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKkntGKEEQRARDLFFA 234
Cdd:PRK06556 185 LSRIRSSKELLSG-GGTASGPVSFMRGADASAGTIKSGGATRRAAKMVILDVDHPDIEEFIETK---AKEEDKIRALRDA 260
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 235 LWIPDL----------------------FMKRVETNQDWSLMcpnecpgldevwgeefeklyasYEKQGRVRKVVKAQQL 292
Cdd:PRK06556 261 GYDMDLggeayssvqyqnannsvrvsdeFMRAVENDGEFGLR----------------------ARTDGEVIETVDAKEL 318
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 293 WYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTeivEYTSKDEVAvCNLASLALNMYVTSEHTYDFKKLAEV 372
Cdd:PRK06556 319 FRKIAEAAWECADPGIQYDDTINDWHTCPESGRINASNPCS---EYMFLDNSS-CNLASLNLMKFLRDDGTFDVESFRHA 394
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 373 TKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLAKE 452
Cdd:PRK06556 395 VELVITAMEISICFADFPTEKIARNTRAFRQLGLGYANLGALLMATGLPYDSDGGRALAAAITSLMTGEAYRRSAELAGV 474
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 453 QGPYETYE-----------------GSPVSKGILQYDMWNVTpTDLWDwKVLKEKiAKYGIRNS--LLIAP-------MP 506
Cdd:PRK06556 475 VGPFEGYArnaephlrvmrkhaaanDAIRPLGEVDAALLEAA-KEAWD-DALELG-EKNGYRNAqaSVLAPtgtigfmMD 551
|
490 500 510 520 530 540 550
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 968121915 507 TASTaqilgnneSIEPYTSNI-YTRRVLSGEFQIVNPHLLKDLTERGlWHEEMKNQI---IACNGSIQSIPEIPDD 578
Cdd:PRK06556 552 CDTT--------GIEPDFALVkYKKLVGGGSMKIVNQTVPRALKKLG-YSEEQIEAIveyIAEHGHIEGAPGLKPE 618
|
|
| PRK06948 |
PRK06948 |
ribonucleotide reductase-like protein; Provisional |
149-539 |
8.45e-30 |
|
ribonucleotide reductase-like protein; Provisional
Pssm-ID: 180772 [Multi-domain] Cd Length: 595 Bit Score: 124.91 E-value: 8.45e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 149 GGIGVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLKKNtgkeeqRA 228
Cdd:PRK06948 121 GGIGYDFSAIPPADARPDADHPDSPGVCAALDRFDRICAALPFRDGRRGAQMAV-LRCDHPDLLAFVAAKRG------RA 193
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 229 RDLFF--ALWIPDLFMKRVETNQDWSLMCPNE--------CPGLDEVWgeefekLYASyekqgrvrkvVKAQQLWYAIIE 298
Cdd:PRK06948 194 RWTTFnlSVAVTDAFMQAVAQDLPWALRHRAPprraaggaLRGADGAW------TYAT----------VPARHLWREIVS 257
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 299 SQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTE--IVEYTSkdevavCNLASLALNMYVT------SEHTYDFKKLA 370
Cdd:PRK06948 258 AARDSAEPGLLFVDTIDAANPLREHERIDATNPCGEqpLPPYGS------CVLGPIDLSRFVRhpfgvgGEPRFDFAALA 331
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 371 EVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFESAEAQLLNKQIFETIYYGALEASCDLA 450
Cdd:PRK06948 332 TAVRIQVRMLDNALDLTRWPLAAHAREARQKRRIGVGVTGLADALTMMRLRYDSPAAREMARYIASDLRHHAYAASAALA 411
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 451 KEQGPY-----ETYEGSPVSKGILQydmwnvtptdlwdwKVLKEKIAKYGIRNSLLIAPMPTASTAQILGNNES--IEPY 523
Cdd:PRK06948 412 AERGAYplcdpAAHLDALRAGPPLP--------------HAVCHAIARHGLRNSHLLSFAPVGSVSLAFGDNCSpgIEPA 477
|
410
....*....|....*.
gi 968121915 524 TSNIYTRRVLSGEFQI 539
Cdd:PRK06948 478 RAWIEHRPVRAGAGGA 493
|
|
| Ribonuc_red_lgN |
pfam00317 |
Ribonucleotide reductase, all-alpha domain; |
46-113 |
6.66e-22 |
|
Ribonucleotide reductase, all-alpha domain;
Pssm-ID: 459758 [Multi-domain] Cd Length: 75 Bit Score: 89.99 E-value: 6.66e-22
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 968121915 46 YNYFGFKTLERSYLLKI-NGKVAERPQHMLMRVSVGIH-----KEDIDAAIETYNLLSERWFTHASPTLFNAGT 113
Cdd:pfam00317 1 LTYLGAKVLEDRYLLKDeDGELLETPQDMFMRVALALAgaeleEDRLELAEEFYDLLSSLKFLPATPTLMNAGT 74
|
|
| PRK07562 |
PRK07562 |
vitamin B12-dependent ribonucleotide reductase; |
115-460 |
1.18e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 236049 [Multi-domain] Cd Length: 1220 Bit Score: 52.27 E-value: 1.18e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 115 RPQLSSCFLLSMKDDSIE--GIYDTLKQCALISKSAGGIGVAVSCIRATGSYIAGtNGNSNGLVPMLRVYNNTARYVDQG 192
Cdd:PRK07562 193 HPQPHACFIQSVEDDLVNegGIMDLWVREARLFKYGSGTGSNFSNLRGEGEKLSG-GGKSSGLMSFLKIGDRAAGAIKSG 271
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 193 GNKRPGAFAIYLEPWHLDIFEFLDLKKntgKEEQR--------------------------------------------- 227
Cdd:PRK07562 272 GTTRRAAKMVIVDIDHPDIEEFIDWKV---KEEQKvaalvtgskivskhlkaimkacvncegdgddcfdpaknpalkrei 348
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 228 --AR---------------------DLFFAL----W------------------IPDLFMKRVETNQDWSLMcpnecpgl 262
Cdd:PRK07562 349 kaAKkalvpenyikrviqfarqgytDIDFPTydtdWdseayltvsgqnsnnsvrVTDEFLRAVENDGDWNLT-------- 420
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 263 devwgeefeklyasYEKQGRVRKVVKAQQLWYAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTeivEYTSKD 342
Cdd:PRK07562 421 --------------ARTDGKVAKTLKARDLWEKIGYAAWASADPGLQFNTTINDWHTCPASGPIRASNPCS---EYMFLD 483
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 343 EVAvCNLASLALNMYVtSEHTYDFKklAEVTKVVVRNLNKIIDIN----YYPVPE-ACLSNKrHRPIGIGVQGLADAFIL 417
Cdd:PRK07562 484 DTA-CNLASLNLLTFR-DEDTKRFD--VEAYEHACRLWTVVLEISvlmaQFPSKEiAELSYE-FRTLGLGYANIGGLLMT 558
|
410 420 430 440
....*....|....*....|....*....|....*....|...
gi 968121915 418 MRYPFESAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYE 460
Cdd:PRK07562 559 MGIPYDSDEGRAICGALSAIMTGVAYATSAEMAKELGPFPGYE 601
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
40-195 |
5.15e-06 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 50.15 E-value: 5.15e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 40 YDRDFSYNYFGFKTLERSYLLKINGKVAERPQ---------HMLMRVSVGIHKEDIDaaiETYNLLSERWFTHASPTLFN 110
Cdd:PRK08332 186 FDGKYSIGKYKLNKYHFERMVNLYRELAEKGKmkvsideflKMLERGEFDKYEKEIE---EYFRLMTNQIFMPNTPALIN 262
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 111 AGTNRPQLSSCFLLSMKDDsIEGIYDTLKQCALISKSAGGigvavsCIRATGSYIAGTNGNSN--GLVPMLRVYNNTARY 188
Cdd:PRK08332 263 SGRPLGMLSACFVVPIEDD-MESIMKAAHDVAMIQKAGGG------CIDGNAKIIFENEGEEHltTMAEMYERYKHLGEF 335
|
....*..
gi 968121915 189 VDQGGNK 195
Cdd:PRK08332 336 YDEEYNR 342
|
|
| RNR_PFL |
cd00576 |
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and ... |
142-468 |
3.27e-05 |
|
Ribonucleotide reductase and Pyruvate formate lyase; Ribonucleotide reductase (RNR) and pyruvate formate lyase (PFL) are believed to have diverged from a common ancestor. They have a structurally similar ten-stranded alpha-beta barrel domain that hosts the active site, and are radical enzymes. RNRs are found in all organisms and provide the only mechanism by which nucleotides are converted to deoxynucleotides. RNRs are separated into three classes based on their metallocofactor usage. Class I RNRs use a diiron-tyrosyl radical while Class II RNRs use coenzyme B12 (adenosylcobalamin, AdoCbl). Class III RNRs use an FeS cluster and S-adenosylmethionine to generate a glycyl radical. PFL, an essential enzyme in anaerobic bacteria, catalyzes the conversion of pyruvate and CoA to acteylCoA and formate in a mechanism that uses a glycyl radical.
Pssm-ID: 153083 [Multi-domain] Cd Length: 401 Bit Score: 46.76 E-value: 3.27e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 142 ALISKSAGGIGVAV--SCIRATGSYIAG-TNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIY----LEPWHLDIFEF 214
Cdd:cd00576 62 AASNQNGGGVSFARasSILSPYGSRDYAkGSGTETDAVEAADAFNLALKEVGQGNGRTGAATGFIggvhKGKGDKISQEF 141
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 215 LDLKKNTGKEEQRardlffaLWIPDLFMKrvetnqdwslmcpnecpgldeVWGEEFEKLYASYEKQGRvrkvvkaqqlwy 294
Cdd:cd00576 142 LNLALANGGEGIP-------LNFPNLSVR---------------------VSSDKPGILVKAVELKQL------------ 181
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 295 aIIESQTETGTPYMLYKDSCNrksnqqnLGTIkcsnlcteiveytskdevavcNLASLALNMYVTSEHTYDfKKLAEVTK 374
Cdd:cd00576 182 -IAEEARKTGSPGIFNDELCN-------LVSL---------------------NLARIMEKAINGSMDVVL-EELEELAF 231
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 375 VVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPF-ESAEAQLLNKQIFETIYYGALEASCDL--AK 451
Cdd:cd00576 232 LAVRALDCVIDSHDERIPTIELGGDERRTVGLGIAGVADLLIKLGLEKvGDPEADDLAAELVDQLKKHLVKATNERgfNF 311
|
330 340
....*....|....*....|
gi 968121915 452 EQG--PYETY-EGSPVSKGI 468
Cdd:cd00576 312 LLGlsPSESNsSGAPATNGV 331
|
|
| PRK08332 |
PRK08332 |
vitamin B12-dependent ribonucleotide reductase; |
152-332 |
3.23e-04 |
|
vitamin B12-dependent ribonucleotide reductase;
Pssm-ID: 181392 [Multi-domain] Cd Length: 1740 Bit Score: 44.37 E-value: 3.23e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 152 GVAVSCIRATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIyLEPWHLDIFEFLDLK-KNTGKEEQRARD 230
Cdd:PRK08332 757 GLNFSKLRPEGDIVGTTTGAASGPVSFMHLIDAVSDVIKQGGVRRGANMGI-LEIWHPDIEKFIHAKeKNIGTNVLSNFN 835
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 968121915 231 LFFALWipDLFMKRVETNQDWSLMCPnecpgldevwgeefeklyasyeKQGRVRKVVKAQQLWYAIIESQTETGTPYMLY 310
Cdd:PRK08332 836 ISVGIW--EDFWEALKEGKKYPLINP----------------------RTGEVVKEIDPKSLFEELAYMAWAKADPGVIF 891
|
170 180
....*....|....*....|....
gi 968121915 311 KDSCNRKS--NQQNLGTIKCSNLC 332
Cdd:PRK08332 892 FDVINRRNvlKEAKGGPIRATNPC 915
|
|
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