NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|968121898|ref|NP_001304980|]
View 

NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, mitochondrial isoform 2 precursor [Homo sapiens]

Protein Classification

ETC complex I subunit( domain architecture ID 9385)

ETC (electron transport chain) complex I subunit similar to mitochondrial NADH dehydrogenase [ubiquinone] iron-sulfur protein 4 (NDUFS4), which is an accessory subunit and may not be involved in catalysis; complex I functions in the transfer of electrons from NADH to the respiratory chain

CATH:  3.30.160.190
Gene Ontology:  GO:0022900|GO:0032981|GO:0006120|GO:0008137|GO:0001932|GO:0042776|GO:0072593
SCOP:  4005098

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
NDUS4 super family cl04760
NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase ...
 76-117 9.86e-24

NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), initially identified in Neurospora crassa as a 21 kDa protein. It is believed that members of this family are not to be involved in catalysis.


The actual alignment was detected with superfamily member pfam04800:

Pssm-ID: 461433  Cd Length: 93  Bit Score: 87.16  E-value: 9.86e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 968121898   76 KVRIFVPARNNMQSGVNNTKKWKMEFDTRE-RWENPLMGWAST 117
Cdd:pfam04800   1 TVRIYKPAKNAMQSGTAKTKKWVLEFDPLEpRWENPLMGWTSS 43
 
Name Accession Description Interval E-value
NDUS4 pfam04800
NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase ...
 76-117 9.86e-24

NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), initially identified in Neurospora crassa as a 21 kDa protein. It is believed that members of this family are not to be involved in catalysis.


Pssm-ID: 461433  Cd Length: 93  Bit Score: 87.16  E-value: 9.86e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 968121898   76 KVRIFVPARNNMQSGVNNTKKWKMEFDTRE-RWENPLMGWAST 117
Cdd:pfam04800   1 TVRIYKPAKNAMQSGTAKTKKWVLEFDPLEpRWENPLMGWTSS 43
 
Name Accession Description Interval E-value
NDUS4 pfam04800
NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase ...
 76-117 9.86e-24

NADH dehydrogenase ubiquinone Fe-S protein 4; This entry represents NADH dehydrogenase [ubiquinone] iron-sulfur protein 4, an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), initially identified in Neurospora crassa as a 21 kDa protein. It is believed that members of this family are not to be involved in catalysis.


Pssm-ID: 461433  Cd Length: 93  Bit Score: 87.16  E-value: 9.86e-24
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 968121898   76 KVRIFVPARNNMQSGVNNTKKWKMEFDTRE-RWENPLMGWAST 117
Cdd:pfam04800   1 TVRIYKPAKNAMQSGTAKTKKWVLEFDPLEpRWENPLMGWTSS 43
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH