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Conserved domains on  [gi|962608764|ref|NP_001304871|]
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R-spondin-2 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Furin-like_2 super family cl25785
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 1-74 5.33e-34

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


The actual alignment was detected with superfamily member pfam15913:

Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 115.61  E-value: 5.33e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 962608764    1 MRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMEC 74
Cdd:pfam15913  29 IRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLHKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin super family cl46269
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 78-131 2.51e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


The actual alignment was detected with superfamily member pfam19028:

Pssm-ID: 480609  Cd Length: 52  Bit Score: 45.35  E-value: 2.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 962608764   78 CEVGHWSEWGTCSrnnRTCGFkwGLETRTRQIVKKPVKDTILCPTIAESRRCKM 131
Cdd:pfam19028   1 CVVSEWSEWSECS---VTCGG--GVQTRTRTVIVEPQNGGRPCPELLERRPCNL 49
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 1-74 5.33e-34

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 115.61  E-value: 5.33e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 962608764    1 MRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMEC 74
Cdd:pfam15913  29 IRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLHKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 78-131 2.51e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 2.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 962608764   78 CEVGHWSEWGTCSrnnRTCGFkwGLETRTRQIVKKPVKDTILCPTIAESRRCKM 131
Cdd:pfam19028   1 CVVSEWSEWSECS---VTCGG--GVQTRTRTVIVEPQNGGRPCPELLERRPCNL 49
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 32-75 9.33e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 38.65  E-value: 9.33e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 962608764  32 ENCDSCFSK--DFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECV 75
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
24-65 1.29e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 35.18  E-value: 1.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 962608764    24 NRCARCRiENCDSCFSK--DFCTKCKVGFYLHRGRCFDECPDGF 65
Cdd:smart00261   2 GECKPCH-PECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPGT 44
 
Name Accession Description Interval E-value
Furin-like_2 pfam15913
Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a ...
 1-74 5.33e-34

Furin-like repeat, cysteine-rich; The furin-like cysteine rich region has been found in a variety of proteins from eukaryotes that are involved in the mechanism of signal transduction by receptor tyrosine kinases, which involves receptor aggregation.


Pssm-ID: 464939 [Multi-domain]  Cd Length: 102  Bit Score: 115.61  E-value: 5.33e-34
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 962608764    1 MRQYGECLHSCPSGYYGHRAPDMNRCARCRIENCDSCFSKDFCTKCKVGFYLHRGRCFDECPDGFAPLEETMEC 74
Cdd:pfam15913  29 IRQYGVCLHSCPPGYFGIRGQEVNRCTKCKAENCESCFSKDFCTKCKEGFYLHKGKCLDTCPEGTAAQNSTMEC 102
TSP1_spondin pfam19028
Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an ...
 78-131 2.51e-07

Spondin-like TSP1 domain; This entry represents a sub-type of TSP1 domains that have an alternative disulphide binding pattern compared to the canonical TSP1 domain.


Pssm-ID: 465948  Cd Length: 52  Bit Score: 45.35  E-value: 2.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....
gi 962608764   78 CEVGHWSEWGTCSrnnRTCGFkwGLETRTRQIVKKPVKDTILCPTIAESRRCKM 131
Cdd:pfam19028   1 CVVSEWSEWSECS---VTCGG--GVQTRTRTVIVEPQNGGRPCPELLERRPCNL 49
FU cd00064
Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is ...
 32-75 9.33e-05

Furin-like repeats. Cysteine rich region. Exact function of the domain is not known. Furin is a serine-kinase dependent proprotein processor. Other members of this family include endoproteases and cell surface receptors.


Pssm-ID: 238021 [Multi-domain]  Cd Length: 49  Bit Score: 38.65  E-value: 9.33e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*.
gi 962608764  32 ENCDSCFSK--DFCTKCKVGFYLHRGRCFDECPDGFAPLEETMECV 75
Cdd:cd00064    4 PSCATCTGPgpDQCTSCRHGFYLDGGTCVSECPEGTYADTEGGVCL 49
FU smart00261
Furin-like repeats;
24-65 1.29e-03

Furin-like repeats;


Pssm-ID: 214589 [Multi-domain]  Cd Length: 45  Bit Score: 35.18  E-value: 1.29e-03
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 962608764    24 NRCARCRiENCDSCFSK--DFCTKCKVGFYLHRGRCFDECPDGF 65
Cdd:smart00261   2 GECKPCH-PECATCTGPgpDDCTSCKHGFFLDGGKCVSECPPGT 44
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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