NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|1008265823|ref|NP_001304107|]
View 

MICOS complex subunit MIC19 isoform 3 [Homo sapiens]

Protein Classification

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MIC19_MIC25 super family cl25739
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-125 5.66e-13

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


The actual alignment was detected with superfamily member pfam05300:

Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 62.40  E-value: 5.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008265823  29 SENVIDRMKESSPSGSKSQRY-----------------------------SGAYGASVSDEELKRRVAEELALEQAKKES 79
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELYKRLEQEQA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1008265823  80 EDQKRLkqAKELDRERAAANEQLTRAILRERICSEEERAKAKHLIK 125
Cdd:pfam05300  81 KVQEEL--ARLAEREREAAQESLTRAILRERASTEDERLKAQQLAK 124
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-125 5.66e-13

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 62.40  E-value: 5.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008265823  29 SENVIDRMKESSPSGSKSQRY-----------------------------SGAYGASVSDEELKRRVAEELALEQAKKES 79
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELYKRLEQEQA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1008265823  80 EDQKRLkqAKELDRERAAANEQLTRAILRERICSEEERAKAKHLIK 125
Cdd:pfam05300  81 KVQEEL--ARLAEREREAAQESLTRAILRERASTEDERLKAQQLAK 124
PLN02316 PLN02316
synthase/transferase
 61-109 1.14e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 37.93  E-value: 1.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1008265823   61 ELKRRVAEELALEQAKKE--SEDQKRL---KQAKELDRERAAANEQLTRAILRE 109
Cdd:PLN02316   252 EEKRRELEKLAKEEAERErqAEEQRRReeeKAAMEADRAQAKAEVEKRREKLQN 305
 
Name Accession Description Interval E-value
MIC19_MIC25 pfam05300
MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ...
 29-125 5.66e-13

MICOS complex subunit MIC19/MIC25; MIC19 (also known as ChChd3) and MIC25 (also known as ChChd6) are components of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. MIC19 plays an important role in the maintenance of the MICOS complex stability and the mitochondrial cristae morphology.


Pssm-ID: 461615 [Multi-domain]  Cd Length: 173  Bit Score: 62.40  E-value: 5.66e-13
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1008265823  29 SENVIDRMKESSPSGSKSQRY-----------------------------SGAYGASVSDEELKRRVAEELALEQAKKES 79
Cdd:pfam05300   1 SENVINRMKEPSAPPPPSAPSppppsppppsptpgpsqapestsappsaeSSGGRQPVDEEELRKKIKEELYKRLEQEQA 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*.
gi 1008265823  80 EDQKRLkqAKELDRERAAANEQLTRAILRERICSEEERAKAKHLIK 125
Cdd:pfam05300  81 KVQEEL--ARLAEREREAAQESLTRAILRERASTEDERLKAQQLAK 124
PLN02316 PLN02316
synthase/transferase
 61-109 1.14e-03

synthase/transferase


Pssm-ID: 215180 [Multi-domain]  Cd Length: 1036  Bit Score: 37.93  E-value: 1.14e-03
                           10        20        30        40        50
                   ....*....|....*....|....*....|....*....|....*....|....
gi 1008265823   61 ELKRRVAEELALEQAKKE--SEDQKRL---KQAKELDRERAAANEQLTRAILRE 109
Cdd:PLN02316   252 EEKRRELEKLAKEEAERErqAEEQRRReeeKAAMEADRAQAKAEVEKRREKLQN 305
PRK00247 PRK00247
putative inner membrane protein translocase component YidC; Validated
 61-124 7.95e-03

putative inner membrane protein translocase component YidC; Validated


Pssm-ID: 178945 [Multi-domain]  Cd Length: 429  Bit Score: 35.21  E-value: 7.95e-03
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1008265823  61 ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQltrAILRERICSEEERAKAKHLI 124
Cdd:PRK00247  331 EIKKTRTAEKNEAKARKKEIAQKRRAAEREINREARQERAA---AMARARARRAAVKAKKKGLI 391
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH