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Conserved domains on  [gi|951233290|ref|NP_001303991|]
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methylosome protein WDR77 isoform 1 [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-334 1.63e-24

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 174 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253
Cdd:COG2319  253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 254 HSQCVTGLVFSPHRldlsqpsppsdsvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDH 332
Cdd:COG2319  329 HTGAVRSVAFSPDG-------------KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADG 394


                 ..
gi 951233290 333 QV 334
Cdd:COG2319  395 TV 396
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-334 1.63e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 174 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253
Cdd:COG2319  253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 254 HSQCVTGLVFSPHRldlsqpsppsdsvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDH 332
Cdd:COG2319  329 HTGAVRSVAFSPDG-------------KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADG 394


                 ..
gi 951233290 333 QV 334
Cdd:COG2319  395 TV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-331 3.25e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 3.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 237
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPhrldlsqpsppsDSVPFLASlSEDCSLAVLDSSLSELFRS-QAHRDFVRDAT 316
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSP------------DGEKLLSS-SSDGTIKLWDLSTGKCLGTlRGHENGVNSVA 226

                        250
                 ....*....|....*
gi 951233290 317 WSPlNHSLLTTVGWD 331
Cdd:cd00200  227 FSP-DGYLLASGSED 240
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-196 6.67e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.67e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 951233290   159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
WD40 pfam00400
WD domain, G-beta repeat;
160-196 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 951233290  160 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-255 7.66e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  96 VASDS--GAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLAQQVVLSSYRAHaAQVTC 172
Cdd:PLN00181 548 VASSNfeGVVQVWDVARSQLVTEMK----EHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 173 VAASPHKDSVFLSCSEDNRILLWDTRCPK-PAsqigCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD-TKSTSCVLS 250
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPKlPL----CTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDlSMSISGINE 698


                 ....*
gi 951233290 251 SAVHS 255
Cdd:PLN00181 699 TPLHS 703
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
94-334 1.63e-24

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 103.07  E-value: 1.63e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  177 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSV 252

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 174 AASPhKDSVFLSCSEDNRILLWDTRCPKPASQIGcsAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAV 253
Cdd:COG2319  253 AFSP-DGRLLASGSADGTVRLWDLATGELLRTLT--GHSGGVNSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTG 328

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 254 HSQCVTGLVFSPHRldlsqpsppsdsvPFLASLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDH 332
Cdd:COG2319  329 HTGAVRSVAFSPDG-------------KTLASGSDDGTVRLWDlATGELLRTLTGHTGAVTSVAFSP-DGRTLASGSADG 394


                 ..
gi 951233290 333 QV 334
Cdd:COG2319  395 TV 396
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-331 3.25e-24

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 100.49  E-value: 3.25e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  80 EAGVADLTWVGERGILV-ASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200    9 TGGVTCVAFSPDGKLLAtGSGDGTIKVWDLETGELLRTLK----GHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWDTRCPKPASQI-GCSAPGylpTSLAWHPQQSEVFVfGDENGTV 237
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPD-GRILSSSSRDKTIKVWDVETGKCLTTLrGHTDWV---NSVAFSPDGTFVAS-SSQDGTI 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPhrldlsqpsppsDSVPFLASlSEDCSLAVLDSSLSELFRS-QAHRDFVRDAT 316
Cdd:cd00200  160 KLWDLRTGKCVATLTGHTGEVNSVAFSP------------DGEKLLSS-SSDGTIKLWDLSTGKCLGTlRGHENGVNSVA 226

                        250
                 ....*....|....*
gi 951233290 317 WSPlNHSLLTTVGWD 331
Cdd:cd00200  227 FSP-DGYLLASGSED 240
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 80-294 5.54e-21

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 91.24  E-value: 5.54e-21
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  80 EAGVADLTWVGERGILVAS-DSGAVELWELDENETLIVSKFckyeHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQV 158
Cdd:cd00200   93 TSYVSSVAFSPDGRILSSSsRDKTIKVWDVETGKCLTTLRG----HTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGK 168

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 159 VLSSYRAHAAQVTCVAASPhKDSVFLSCSEDNRILLWDTRCPKP-ASQIGCSAPgylPTSLAWHPQqSEVFVFGDENGTV 237
Cdd:cd00200  169 CVATLTGHTGEVNSVAFSP-DGEKLLSSSSDGTIKLWDLSTGKClGTLRGHENG---VNSVAFSPD-GYLLASGSEDGTI 243

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 951233290 238 SLVDTKSTSCVLSSAVHSQCVTGLVFSPhrldlsqpsppsdSVPFLASLSEDCSLAV 294
Cdd:cd00200  244 RVWDLRTGECVQTLSGHTNSVTSLAWSP-------------DGKRLASGSADGTIRI 287
WD40 COG2319
WD40 repeat [General function prediction only];
46-334 1.21e-19

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 89.20  E-value: 1.21e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  46 ASSLSGRCWAGSLWLFKDPCAAPNEGFCSAGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCkyEHD 125
Cdd:COG2319    1 ALSADGAALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLL--GHT 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 126 DIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPhkDSVFL-SCSEDNRILLWDTRCPKPAS 204
Cdd:COG2319   79 AAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSP--DGKTLaSGSADGTVRLWDLATGKLLR 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 205 QIgcSAPGYLPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPhrldlsqpsppsDSvPFLA 284
Cdd:COG2319  157 TL--TGHSGAVTSVAFSP-DGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSP------------DG-KLLA 220

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|.
gi 951233290 285 SLSEDCSLAVLD-SSLSELFRSQAHRDFVRDATWSPlNHSLLTTVGWDHQV 334
Cdd:COG2319  221 SGSADGTVRLWDlATGKLLRTLTGHSGSVRSVAFSP-DGRLLASGSADGTV 270
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 122-338 1.11e-16

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 79.30  E-value: 1.11e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 122 YEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCVAASPHKDSVFlSCSEDNRILLWDTRCPK 201
Cdd:cd00200    6 KGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLA-SGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 202 PASQIGCSAPGylPTSLAWHPqQSEVFVFGDENGTVSLVDTKSTSCVLSSAVHSQCVTGLVFSPHRLdlsqpsppsdsvp 281
Cdd:cd00200   85 CVRTLTGHTSY--VSSVAFSP-DGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGT------------- 148

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 951233290 282 FLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPLNHSLLTTVG------WDHQVVHHV 338
Cdd:cd00200  149 FVASSSQDGTIKLWDLRTGKCVATlTGHTGEVNSVAFSPDGEKLLSSSSdgtiklWDLSTGKCL 212
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 91-196 1.23e-13

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 70.44  E-value: 1.23e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  91 ERGILVASDSGAVELWELDenetlivSKFCKYE---HDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHA 167
Cdd:cd00200  189 GEKLLSSSSDGTIKLWDLS-------TGKCLGTlrgHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHT 261

                         90       100
                 ....*....|....*....|....*....
gi 951233290 168 AQVTCVAASPHKdSVFLSCSEDNRILLWD 196
Cdd:cd00200  262 NSVTSLAWSPDG-KRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
94-198 5.63e-13

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 69.55  E-value: 5.63e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  94 ILVASDSGAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDLAQQVVLSSYRAHAAQVTCV 173
Cdd:COG2319  303 LASGSDDGTVRLWDLATGKLLRTLT----GHTGAVRSVAFSPDGKTLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSV 378

                         90       100
                 ....*....|....*....|....*
gi 951233290 174 AASPHkDSVFLSCSEDNRILLWDTR 198
Cdd:COG2319  379 AFSPD-GRTLASGSADGTVRLWDLA 402
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 163-334 1.04e-11

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 64.66  E-value: 1.04e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 163 YRAHAAQVTCVAASPHKDsVFLSCSEDNRILLWDT-RCPKPASQIGCSAPGylpTSLAWHPqQSEVFVFGDENGTVSLVD 241
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGK-LLATGSGDGTIKVWDLeTGELLRTLKGHTGPV---RDVAASA-DGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 242 TKSTSCVLSSAVHSQCVTGLVFSPHRldlsqpsppsdsvPFLASLSEDCSLAVLDSSLSELFRS-QAHRDFVRDATWSPl 320
Cdd:cd00200   80 LETGECVRTLTGHTSYVSSVAFSPDG-------------RILSSSSRDKTIKVWDVETGKCLTTlRGHTDWVNSVAFSP- 145

                        170
                 ....*....|....
gi 951233290 321 NHSLLTTVGWDHQV 334
Cdd:cd00200  146 DGTFVASSSQDGTI 159
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 159-196 6.67e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 39.60  E-value: 6.67e-05
                           10        20        30
                   ....*....|....*....|....*....|....*...
gi 951233290   159 VLSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:smart00320   4 LLKTLKGHTGPVTSVAFSPD-GKYLASGSDDGTIKLWD 40
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
158-265 2.00e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 42.37  E-value: 2.00e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 158 VVLSSYRAHAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDENGTV 237
Cdd:COG3391   58 AGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDLATGKVVATI---PVGGGPRGLAVDPDGGRLYVADSGNGRV 134

                         90       100
                 ....*....|....*....|....*...
gi 951233290 238 SLVDTKSTSCVLSSAVHSQcVTGLVFSP 265
Cdd:COG3391  135 SVIDTATGKVVATIPVGAG-PHGIAVDP 161
WD40 pfam00400
WD domain, G-beta repeat;
160-196 2.82e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 38.10  E-value: 2.82e-04
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 951233290  160 LSSYRAHAAQVTCVAASPHkDSVFLSCSEDNRILLWD 196
Cdd:pfam00400   4 LKTLEGHTGSVTSLAFSPD-GKLLASGSDDGTVKVWD 39
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
75-265 5.29e-04

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 40.83  E-value: 5.29e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  75 AGVQTEAGVADLTWVGERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154
Cdd:COG3391   18 LAALAVAVAALGLGGGGPLLAAASGGVVGAAVGGGGVALLAGLGLGAAAVADADGADAGADGRRLYVANSGSGRVSVIDL 97

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 155 AQQVVLSSYRAhAAQVTCVAASPHKDSVFLSCSEDNRILLWDTRCPKPASQIgcsAPGYLPTSLAWHPQQSEVFVFGDEN 234
Cdd:COG3391   98 ATGKVVATIPV-GGGPRGLAVDPDGGRLYVADSGNGRVSVIDTATGKVVATI---PVGAGPHGIAVDPDGKRLYVANSGS 173

                        170       180       190
                 ....*....|....*....|....*....|....*
gi 951233290 235 GTVSLV----DTKSTScVLSSAVHSQCVTGLVFSP 265
Cdd:COG3391  174 NTVSVIvsviDTATGK-VVATIPVGGGPVGVAVSP 207
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 96-255 7.66e-04

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 41.61  E-value: 7.66e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290  96 VASDS--GAVELWELDENETLIVSKfckyEHDDIVSTVSVLSSG-TQAVSGSKDICIKVWDLAQQVVLSSYRAHaAQVTC 172
Cdd:PLN00181 548 VASSNfeGVVQVWDVARSQLVTEMK----EHEKRVWSIDYSSADpTLLASGSDDGSVKLWSINQGVSIGTIKTK-ANICC 622

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 951233290 173 VAASPHKDSVFLSCSEDNRILLWDTRCPK-PAsqigCSAPGYLPTSLAWHPQQSEVFVFGDENGTVSLVD-TKSTSCVLS 250
Cdd:PLN00181 623 VQFPSESGRSLAFGSADHKVYYYDLRNPKlPL----CTMIGHSKTVSYVRFVDSSTLVSSSTDNTLKLWDlSMSISGINE 698


                 ....*
gi 951233290 251 SAVHS 255
Cdd:PLN00181 699 TPLHS 703
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 88-154 5.20e-03

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 38.36  E-value: 5.20e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 951233290  88 WVG----ERGILVASDSGAVELWELDENETLIVSKFCKYEHDDIVSTVSVLSSGTQAVSGSKDICIKVWDL 154
Cdd:cd22857   85 FVGlhlfSGTLLTCTSKGSLRSTKLPDDSTASSSPTAWVCLGGNLLCMRVDPNENYFAFGGKEVELNVWDL 155
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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