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Conserved domains on  [gi|946724705|ref|NP_001303871|]
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F-box/LRR-repeat protein 12 isoform c [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1907945)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
AMN1 super family cl39120
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 68-173 1.47e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


The actual alignment was detected with superfamily member cd09293:

Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 38.85  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705  68 SLPSTLRTLELHSCEISmawlhkqqDPTVLPLLECivldrvpafrdehlqgltrfRALRSLVLGGTYRVTETGLDAGLQE 147
Cdd:cd09293   25 ILHSGLEWLELYMCPIS--------DPPLDQLSNC--------------------NKLKKLILPGSKLIDDEGLIALAQS 76

                         90       100
                 ....*....|....*....|....*.
gi 946724705 148 LSYLQRLEVLGCTLSADSTLLAISRH 173
Cdd:cd09293   77 CPNLQVLDLRACENITDSGIVALATN 102
PPP1R42 super family cl42388
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-238 9.41e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


The actual alignment was detected with superfamily member cd21340:

Pssm-ID: 455733 [Multi-domain]  Cd Length: 220  Bit Score: 36.69  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705 114 EHLQGLTRFRALRSLVLGGTY-RVTEtGLDA--GLQELsYL--QRLEvLGCTLSADS-TLLAISRHLRdvrkiRLTVRGL 187
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRiSVVE-GLENltNLEEL-HIenQRLP-PGEKLTFDPrSLAALSNSLR-----VLNISGN 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 946724705 188 SAPGLAVLEGMPALESLCLQGPLVTpempSPTEILSSCLTMPKLRVLELQG 238
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQIS----DLEELLDLLSSWPSLRELDLTG 177
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 68-173 1.47e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 38.85  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705  68 SLPSTLRTLELHSCEISmawlhkqqDPTVLPLLECivldrvpafrdehlqgltrfRALRSLVLGGTYRVTETGLDAGLQE 147
Cdd:cd09293   25 ILHSGLEWLELYMCPIS--------DPPLDQLSNC--------------------NKLKKLILPGSKLIDDEGLIALAQS 76

                         90       100
                 ....*....|....*....|....*.
gi 946724705 148 LSYLQRLEVLGCTLSADSTLLAISRH 173
Cdd:cd09293   77 CPNLQVLDLRACENITDSGIVALATN 102
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-238 3.27e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705  47 KCPNLKRLclhvaDLSMVPITSLPST------LRTLELHSCEIsmawlhkqqdpTVLPllecivldrvpafrdEHLQGLT 120
Cdd:COG4886  134 NLTNLKEL-----DLSNNQLTDLPEPlgnltnLKSLDLSNNQL-----------TDLP---------------EELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705 121 RfraLRSLVLGGTyRVTEtgLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLR--DVRKIRLTVrglsapgLAVLEGM 198
Cdd:COG4886  183 N---LKELDLSNN-QITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLEtlDLSNNQLTD-------LPELGNL 249

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 946724705 199 PALESLCLQGplvtpempspTEI--LSSCLTMPKLRVLELQG 238
Cdd:COG4886  250 TNLEELDLSN----------NQLtdLPPLANLTNLKTLDLSN 281
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-238 9.41e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.69  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705 114 EHLQGLTRFRALRSLVLGGTY-RVTEtGLDA--GLQELsYL--QRLEvLGCTLSADS-TLLAISRHLRdvrkiRLTVRGL 187
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRiSVVE-GLENltNLEEL-HIenQRLP-PGEKLTFDPrSLAALSNSLR-----VLNISGN 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 946724705 188 SAPGLAVLEGMPALESLCLQGPLVTpempSPTEILSSCLTMPKLRVLELQG 238
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQIS----DLEELLDLLSSWPSLRELDLTG 177
 
Name Accession Description Interval E-value
AMN1 cd09293
Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in ...
 68-173 1.47e-03

Antagonist of mitotic exit network protein 1; Amn1 has been functionally characterized in Saccharomyces cerevisiae as a component of the Antagonist of MEN pathway (AMEN). The AMEN network is activated by MEN (mitotic exit network) via an active Cdc14, and in turn switches off MEN. Amn1 constitutes one of the alternative mechanisms by which MEN may be disrupted. Specifically, Amn1 binds Tem1 (Termination of M-phase, a GTPase that belongs to the RAS superfamily), and disrupts its association with Cdc15, the primary downstream target. Amn1 is a leucine-rich repeat (LRR) protein, with 12 repeats in the S. cerevisiae ortholog. As a negative regulator of the signal transduction pathway MEN, overexpression of AMN1 slows the growth of wild type cells. The function of the vertebrate members of this family has not been determined experimentally, they have fewer LRRs that determine the extent of this model.


Pssm-ID: 187754 [Multi-domain]  Cd Length: 226  Bit Score: 38.85  E-value: 1.47e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705  68 SLPSTLRTLELHSCEISmawlhkqqDPTVLPLLECivldrvpafrdehlqgltrfRALRSLVLGGTYRVTETGLDAGLQE 147
Cdd:cd09293   25 ILHSGLEWLELYMCPIS--------DPPLDQLSNC--------------------NKLKKLILPGSKLIDDEGLIALAQS 76

                         90       100
                 ....*....|....*....|....*.
gi 946724705 148 LSYLQRLEVLGCTLSADSTLLAISRH 173
Cdd:cd09293   77 CPNLQVLDLRACENITDSGIVALATN 102
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
47-238 3.27e-03

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 38.38  E-value: 3.27e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705  47 KCPNLKRLclhvaDLSMVPITSLPST------LRTLELHSCEIsmawlhkqqdpTVLPllecivldrvpafrdEHLQGLT 120
Cdd:COG4886  134 NLTNLKEL-----DLSNNQLTDLPEPlgnltnLKSLDLSNNQL-----------TDLP---------------EELGNLT 182

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705 121 RfraLRSLVLGGTyRVTEtgLDAGLQELSYLQRLEVLGCTLSADSTLLAISRHLR--DVRKIRLTVrglsapgLAVLEGM 198
Cdd:COG4886  183 N---LKELDLSNN-QITD--LPEPLGNLTNLEELDLSGNQLTDLPEPLANLTNLEtlDLSNNQLTD-------LPELGNL 249

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 946724705 199 PALESLCLQGplvtpempspTEI--LSSCLTMPKLRVLELQG 238
Cdd:COG4886  250 TNLEELDLSN----------NQLtdLPPLANLTNLKTLDLSN 281
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 114-238 9.41e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 36.69  E-value: 9.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 946724705 114 EHLQGLTRFRALRSLVLGGTY-RVTEtGLDA--GLQELsYL--QRLEvLGCTLSADS-TLLAISRHLRdvrkiRLTVRGL 187
Cdd:cd21340   59 EKIENLENLVNLKKLYLGGNRiSVVE-GLENltNLEEL-HIenQRLP-PGEKLTFDPrSLAALSNSLR-----VLNISGN 130

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|.
gi 946724705 188 SAPGLAVLEGMPALESLCLQGPLVTpempSPTEILSSCLTMPKLRVLELQG 238
Cdd:cd21340  131 NIDSLEPLAPLRNLEQLDASNNQIS----DLEELLDLLSSWPSLRELDLTG 177
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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