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Conserved domains on  [gi|943463919|ref|NP_001303796|]
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26S rRNA (cytosine-C(5))-methyltransferase nsun-1 [Caenorhabditis elegans]

Protein Classification

NOL1/NOP2/SUN domain family protein( domain architecture ID 1003105)

NOL1/NOP2/SUN domain (NSUN) family protein such as mammalian nucleolar protein NOP2 which is required for nucleolar maturation and ribosome biogenesis

Gene Ontology:  GO:0003723|GO:0000027|GO:0008173|GO:0001510

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
nop2p super family cl33194
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 2-255 3.10e-90

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


The actual alignment was detected with superfamily member TIGR00446:

Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 273.57  E-value: 3.10e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919    2 NVDPAADWTKVGlvVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLF 81
Cdd:TIGR00446  23 VLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDMAAAPGGKTTQISQLMKNKGCIV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   82 ANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPnGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQR 161
Cdd:TIGR00446 101 ANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLL-KFDAILLDAPCSGEGVIRKDPSRKRNWSEEDIKYCSLLQK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  162 QLILSALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLERRhcelvPTGLSIGVDGYTRFRDYRFHPSLSMTKRYYPH 241
Cdd:TIGR00446 180 ELIDAAIDALKP----GGVLVYSTCSLEVEENEEVIDYILRKR-----PDVVEEIIKGDEFFGINIGKGEVKGALRVFPQ 250

                         250
                  ....*....|....
gi 943463919  242 VHNIDGFYVAKIKK 255
Cdd:TIGR00446 251 NYDCEGFFVAKLRK 264
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 2-255 3.10e-90

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 273.57  E-value: 3.10e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919    2 NVDPAADWTKVGlvVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLF 81
Cdd:TIGR00446  23 VLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDMAAAPGGKTTQISQLMKNKGCIV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   82 ANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPnGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQR 161
Cdd:TIGR00446 101 ANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLL-KFDAILLDAPCSGEGVIRKDPSRKRNWSEEDIKYCSLLQK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  162 QLILSALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLERRhcelvPTGLSIGVDGYTRFRDYRFHPSLSMTKRYYPH 241
Cdd:TIGR00446 180 ELIDAAIDALKP----GGVLVYSTCSLEVEENEEVIDYILRKR-----PDVVEEIIKGDEFFGINIGKGEVKGALRVFPQ 250

                         250
                  ....*....|....
gi 943463919  242 VHNIDGFYVAKIKK 255
Cdd:TIGR00446 251 NYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 6-255 1.27e-76

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 244.53  E-value: 1.27e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   6 AADWTKVGLVVyDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDA 85
Cdd:COG0144  204 PTPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDI 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  86 NFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLIL 165
Cdd:COG0144  283 SEHRLKRLRENLARLGLSNVEVVVADARELLEWLPGKFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLD 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 166 SALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLERRH-CELVPTGLSIGVDGYTRFRDYRFhpslsmtkryYPHVHN 244
Cdd:COG0144  363 AAARLLKP----GGRLVYSTCSLLPEENEEVVEAFLARHPdFELVPLAELLPGLALTDGGYLRL----------LPHRHG 428

                        250
                 ....*....|.
gi 943463919 245 IDGFYVAKIKK 255
Cdd:COG0144  429 TDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 45-254 2.45e-76

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 235.40  E-value: 2.45e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   45 VMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSK-IRPNGF 123
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQwLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  124 DRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLER 203
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKP----GGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 943463919  204 RH-CELVPT------GLSIGVdGYTRfrdyrfhpslsmtkRYYPHVHNIDGFYVAKIK 254
Cdd:pfam01189 157 HPdVELVPTplfepvGLAIGE-QPTL--------------RLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
26-255 2.55e-52

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 180.76  E-value: 2.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  26 TPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNT 105
Cdd:PRK14902 224 TDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNI 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 106 VVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAnspnGGYLVYST 185
Cdd:PRK14902 304 ETKALDARKVHEKFAEKFDKILVDAPCSGLGVIRRKPDIKYNKTKEDIESLQEIQLEILESVAQYLKK----GGILVYST 379

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943463919 186 CSVLVEENEAVVN-FLLERRHCELVPTGLS-IGVDGYTRFRDYRfhpslsmtkRYYPHVHNIDGFYVAKIKK 255
Cdd:PRK14902 380 CTIEKEENEEVIEaFLEEHPEFELVPLQHEkPDELVYEVKDGYL---------QILPNDYGTDGFFIAKLRK 442
 
Name Accession Description Interval E-value
nop2p TIGR00446
NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base ...
 2-255 3.10e-90

NOL1/NOP2/sun family putative RNA methylase; [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 188051 [Multi-domain]  Cd Length: 264  Bit Score: 273.57  E-value: 3.10e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919    2 NVDPAADWTKVGlvVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLF 81
Cdd:TIGR00446  23 VLEPTCEEYFFE--VKESPFSIGSTPEYLFGYYYPQEASSMIPPIALEPREDERVLDMAAAPGGKTTQISQLMKNKGCIV 100

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   82 ANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPnGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQR 161
Cdd:TIGR00446 101 ANEISKSRTKALISNINRMGVLNTIVINADGRKFGAYLL-KFDAILLDAPCSGEGVIRKDPSRKRNWSEEDIKYCSLLQK 179

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  162 QLILSALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLERRhcelvPTGLSIGVDGYTRFRDYRFHPSLSMTKRYYPH 241
Cdd:TIGR00446 180 ELIDAAIDALKP----GGVLVYSTCSLEVEENEEVIDYILRKR-----PDVVEEIIKGDEFFGINIGKGEVKGALRVFPQ 250

                         250
                  ....*....|....
gi 943463919  242 VHNIDGFYVAKIKK 255
Cdd:TIGR00446 251 NYDCEGFFVAKLRK 264
RsmB COG0144
16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and ...
 6-255 1.27e-76

16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family [Translation, ribosomal structure and biogenesis]; 16S rRNA C967 or C1407 C5-methylase, RsmB/RsmF family is part of the Pathway/BioSystem: 16S rRNA modification


Pssm-ID: 439914 [Multi-domain]  Cd Length: 441  Bit Score: 244.53  E-value: 1.27e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   6 AADWTKVGLVVyDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDA 85
Cdd:COG0144  204 PTPLSPDGLRL-EGPGPVTALPGFREGLFSVQDEASQLVALLLDPKPGERVLDLCAAPGGKTLHLAELMGNKGRVVAVDI 282

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  86 NFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLIL 165
Cdd:COG0144  283 SEHRLKRLRENLARLGLSNVEVVVADARELLEWLPGKFDRVLLDAPCSGTGTLRRHPDIKWRRTPEDIAELAALQRELLD 362

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 166 SALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLERRH-CELVPTGLSIGVDGYTRFRDYRFhpslsmtkryYPHVHN 244
Cdd:COG0144  363 AAARLLKP----GGRLVYSTCSLLPEENEEVVEAFLARHPdFELVPLAELLPGLALTDGGYLRL----------LPHRHG 428

                        250
                 ....*....|.
gi 943463919 245 IDGFYVAKIKK 255
Cdd:COG0144  429 TDGFFIARLRK 439
Methyltr_RsmB-F pfam01189
16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ...
 45-254 2.45e-76

16S rRNA methyltransferase RsmB/F; This is the catalytic core of this SAM-dependent 16S ribosomal methyltransferase RsmB/F enzyme. There is a catalytic cysteine residue at 180 in UniProtKB:Q5SII2, with another highly conserved cysteine at residue 230. It methylates the C(5) position of cytosine 2870 (m5C2870) in 25S rRNA.


Pssm-ID: 426109 [Multi-domain]  Cd Length: 199  Bit Score: 235.40  E-value: 2.45e-76
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   45 VMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNTVVCNLGGEEFSK-IRPNGF 123
Cdd:pfam01189   1 AILLAPQEGETILDMCAAPGGKTTHIAELMKNQGTVVAVDINKHRLKRVAENIHRLGVTNTIILNGDGRQPDQwLGGVLF 80

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  124 DRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAnspnGGYLVYSTCSVLVEENEAVVNFLLER 203
Cdd:pfam01189  81 DRILLDAPCSGTGVIRRHPDVKWLRQEADIAQLAQLQKELLSAAIDLLKP----GGVLVYSTCSVLPEENEAVIEYFLQK 156

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*...
gi 943463919  204 RH-CELVPT------GLSIGVdGYTRfrdyrfhpslsmtkRYYPHVHNIDGFYVAKIK 254
Cdd:pfam01189 157 HPdVELVPTplfepvGLAIGE-QPTL--------------RLLPHTHNGDGFFIAKLR 199
PRK14902 PRK14902
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
26-255 2.55e-52

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 237857 [Multi-domain]  Cd Length: 444  Bit Score: 180.76  E-value: 2.55e-52
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  26 TPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNT 105
Cdd:PRK14902 224 TDLFKDGLITIQDESSMLVAPALDPKGGDTVLDACAAPGGKTTHIAELLKNTGKVVALDIHEHKLKLIEENAKRLGLTNI 303

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 106 VVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAnspnGGYLVYST 185
Cdd:PRK14902 304 ETKALDARKVHEKFAEKFDKILVDAPCSGLGVIRRKPDIKYNKTKEDIESLQEIQLEILESVAQYLKK----GGILVYST 379

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 943463919 186 CSVLVEENEAVVN-FLLERRHCELVPTGLS-IGVDGYTRFRDYRfhpslsmtkRYYPHVHNIDGFYVAKIKK 255
Cdd:PRK14902 380 CTIEKEENEEVIEaFLEEHPEFELVPLQHEkPDELVYEVKDGYL---------QILPNDYGTDGFFIAKLRK 442
yebU PRK11933
rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed
 18-257 1.33e-50

rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed


Pssm-ID: 183387 [Multi-domain]  Cd Length: 470  Bit Score: 177.02  E-value: 1.33e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  18 DSQVPVGATPEYLAGHYMIQGLNSLLPVMAL--APQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIG 95
Cdd:PRK11933  77 EDALPLGNTAEHLSGLFYIQEASSMLPVAALfaDDNAPQRVLDMAAAPGSKTTQIAALMNNQGAIVANEYSASRVKVLHA 156

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  96 NLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAns 175
Cdd:PRK11933 157 NISRCGVSNVALTHFDGRVFGAALPETFDAILLDAPCSGEGTVRKDPDALKNWSPESNLEIAATQRELIESAFHALKP-- 234

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 176 pnGGYLVYSTCSVLVEENEAVVNFLLER--RHCELVPTG-LSIGVD------GYtrfrdyrFHpslsmtkrYYPHVHNID 246
Cdd:PRK11933 235 --GGTLVYSTCTLNREENQAVCLWLKETypDAVEFEPLGdLFPGAEkalteeGF-------LH--------VFPQIYDSE 297

                        250
                 ....*....|.
gi 943463919 247 GFYVAKIKKLS 257
Cdd:PRK11933 298 GFFVARLRKTA 308
PRK14901 PRK14901
16S rRNA methyltransferase B; Provisional
 27-257 4.10e-41

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237856 [Multi-domain]  Cd Length: 434  Bit Score: 150.85  E-value: 4.10e-41
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  27 PEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVNNTV 106
Cdd:PRK14901 227 PGYEEGWWTVQDRSAQLVAPLLDPQPGEVILDACAAPGGKTTHIAELMGDQGEIWAVDRSASRLKKLQENAQRLGLKSIK 306

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 107 VCNLGGEEFSKIRP---NGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDanspNGGYLVY 183
Cdd:PRK14901 307 ILAADSRNLLELKPqwrGYFDRILLDAPCSGLGTLHRHPDARWRQTPEKIQELAPLQAELLESLAPLLK----PGGTLVY 382

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 943463919 184 STCSVLVEENEAVVNFLLERrhcelvptglsigvdgytrfrdyrfHPSLSM---TKRYYPHVHNIDGFYVAKIKKLS 257
Cdd:PRK14901 383 ATCTLHPAENEAQIEQFLAR-------------------------HPDWKLeppKQKIWPHRQDGDGFFMAVLRKKS 434
PRK10901 PRK10901
16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;
15-255 1.60e-40

16S rRNA (cytosine(967)-C(5))-methyltransferase RsmB;


Pssm-ID: 236790 [Multi-domain]  Cd Length: 427  Bit Score: 148.80  E-value: 1.60e-40
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  15 VVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLfANDANFTRCRAII 94
Cdd:PRK10901 207 IRLETPVPVHQLPGFAEGWVSVQDAAAQLAATLLAPQNGERVLDACAAPGGKTAHILELAPQAQVV-ALDIDAQRLERVR 285

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  95 GNLHRLGVNNTVVCNLGG--EEFSKIRPngFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLilsaLDSLD 172
Cdd:PRK10901 286 ENLQRLGLKATVIVGDARdpAQWWDGQP--FDRILLDAPCSATGVIRRHPDIKWLRRPEDIAALAALQSEI----LDALW 359

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 173 ANSPNGGYLVYSTCSVLVEENEAVV-NFLleRRH--CELVPTGLSIGVdGYTRFrdyrfhpslsmtkryyPHVHNIDGFY 249
Cdd:PRK10901 360 PLLKPGGTLLYATCSILPEENEQQIkAFL--ARHpdAELLDTGTPQQP-GRQLL----------------PGEEDGDGFF 420


                 ....*.
gi 943463919 250 VAKIKK 255
Cdd:PRK10901 421 YALLIK 426
rsmB TIGR00563
16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. ...
 15-255 1.77e-39

16S rRNA (cytosine(967)-C(5))-methyltransferase; This protein is also known as sun protein. The reading frame was originally interpreted as two reading frames, fmu and fmv. The recombinant protein from E. coli was shown to methylate only C967 of small subunit (16S) ribosomal RNA and to produce only m5C at that position. The seed alignment is built from bacterial sequences only. Eukaryotic homologs include Nop2, a protein required for processing pre-rRNA, that is likely also a rRNA methyltransferase, although the fine specificity may differ. Cutoff scores are set to avoid treating archaeal and eukaroytic homologs automatically as functionally equivalent, although they may have very similar roles. [Protein synthesis, tRNA and rRNA base modification]


Pssm-ID: 273141 [Multi-domain]  Cd Length: 426  Bit Score: 146.17  E-value: 1.77e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   15 VVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVlFANDANFTRCRAII 94
Cdd:TIGR00563 201 VRLETPAAVHALPGFEEGWVTVQDASAQWVATWLAPQNEETILDACAAPGGKTTHILELAPQAQV-VALDIHEHRLKRVY 279

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919   95 GNLHRLGVNNTV-VCNLGGEEFSKIRPNG-FDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQrQLILSALDSLd 172
Cdd:TIGR00563 280 ENLKRLGLTIKAeTKDGDGRGPSQWAENEqFDRILLDAPCSATGVIRRHPDIKWLRKPRDIAELAELQ-SEILDAIWPL- 357

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  173 anSPNGGYLVYSTCSVLVEENEAVVN-FLLERRHCELVPTGLSIGVDgytrfrdyrfhpslSMTKRYYPHVHNIDGFYVA 251
Cdd:TIGR00563 358 --LKTGGTLVYATCSVLPEENSEQIKaFLQEHPDFPFEKTGTPEQVR--------------DGGLQILPHAEEGDGFFYA 421


                  ....
gi 943463919  252 KIKK 255
Cdd:TIGR00563 422 KLIK 425
PRK14904 PRK14904
16S rRNA methyltransferase B; Provisional
 37-210 1.95e-32

16S rRNA methyltransferase B; Provisional


Pssm-ID: 237858 [Multi-domain]  Cd Length: 445  Bit Score: 127.10  E-value: 1.95e-32
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  37 QGLNSLLpvmaLAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCRAIIGNLHRLGVnnTVVCNLGGEEFS 116
Cdd:PRK14904 239 QALACLL----LNPQPGSTVLDLCAAPGGKSTFMAELMQNRGQITAVDRYPQKLEKIRSHASALGI--TIIETIEGDARS 312

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919 117 KIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSLDAnspnGGYLVYSTCSVLVEENEAV 196
Cdd:PRK14904 313 FSPEEQPDAILLDAPCTGTGVLGRRAELRWKLTPEKLAELVGLQAELLDHAASLLKP----GGVLVYATCSIEPEENELQ 388

                        170
                 ....*....|....*
gi 943463919 197 VN-FLleRRHCELVP 210
Cdd:PRK14904 389 IEaFL--QRHPEFSA 401
PRK14903 PRK14903
16S rRNA methyltransferase B; Provisional
 12-211 1.95e-25

16S rRNA methyltransferase B; Provisional


Pssm-ID: 184896 [Multi-domain]  Cd Length: 431  Bit Score: 107.27  E-value: 1.95e-25
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  12 VGLVVYDSQVPVGATPEYLAGHYMIQGLNSLLPVMALAPQPGDRVLDMCSAPGGKTSHIAALMKNSGVLFANDANFTRCR 91
Cdd:PRK14903 197 FSLIVRKLGVNMNDSRVIKDGLATVQGESSQIVPLLMELEPGLRVLDTCAAPGGKTTAIAELMKDQGKILAVDISREKIQ 276

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  92 AIIGNLHRLGVNNTVVCNLGGEEFSKIRPNGFDRILLDAPCSGTGVIWKDQSVKTSKDSQDVQRRHTMQRQLILSALDSL 171
Cdd:PRK14903 277 LVEKHAKRLKLSSIEIKIADAERLTEYVQDTFDRILVDAPCTSLGTARNHPEVLRRVNKEDFKKLSEIQLRIVSQAWKLL 356

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 943463919 172 DanspNGGYLVYSTCSVLVEENEAVVN-FLLERRHCELVPT 211
Cdd:PRK14903 357 E----KGGILLYSTCTVTKEENTEVVKrFVYEQKDAEVIDI 393
PRK14968 PRK14968
putative methyltransferase; Provisional
 47-131 2.93e-04

putative methyltransferase; Provisional


Pssm-ID: 237872 [Multi-domain]  Cd Length: 188  Bit Score: 41.42  E-value: 2.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 943463919  47 ALAPQPGDRVLDMcsapGGKTSHIAALMKNSGV-LFANDANFTRCRAIIGNLHRLGVNNTVV----CNLggeeFSKIRPN 121
Cdd:PRK14968  18 NAVDKKGDRVLEV----GTGSGIVAIVAAKNGKkVVGVDINPYAVECAKCNAKLNNIRNNGVevirSDL----FEPFRGD 89

                         90
                 ....*....|
gi 943463919 122 GFDRILLDAP 131
Cdd:PRK14968  90 KFDVILFNPP 99
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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