![](files/infoQ.gif)
vitamin K-dependent protein S isoform 1 precursor [Homo sapiens]
List of domain hits
![](files/help.png)
Name | Accession | Description | Interval | E-value | |||
Laminin_G_1 | pfam00054 | Laminin G domain; |
361-491 | 1.42e-37 | |||
Laminin G domain; : Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 136.29 E-value: 1.42e-37
|
|||||||
GLA | smart00069 | Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ... |
58-117 | 2.92e-27 | |||
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration. : Pssm-ID: 214503 Cd Length: 65 Bit Score: 104.70 E-value: 2.92e-27
|
|||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
200-231 | 6.42e-08 | |||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 6.42e-08
|
|||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
279-314 | 3.50e-06 | |||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. : Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 3.50e-06
|
|||||||
LamG | smart00282 | Laminin G domain; |
541-679 | 3.99e-05 | |||
Laminin G domain; : Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 43.87 E-value: 3.99e-05
|
|||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
233-274 | 6.72e-05 | |||
Calcium-binding EGF-like domain; : Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 6.72e-05
|
|||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
151-187 | 8.71e-04 | |||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. : Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 8.71e-04
|
|||||||
Name | Accession | Description | Interval | E-value | ||||
Laminin_G_1 | pfam00054 | Laminin G domain; |
361-491 | 1.42e-37 | ||||
Laminin G domain; Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 136.29 E-value: 1.42e-37
|
||||||||
GLA | smart00069 | Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ... |
58-117 | 2.92e-27 | ||||
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration. Pssm-ID: 214503 Cd Length: 65 Bit Score: 104.70 E-value: 2.92e-27
|
||||||||
LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
344-487 | 1.12e-24 | ||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 100.57 E-value: 1.12e-24
|
||||||||
LamG | smart00282 | Laminin G domain; |
356-487 | 1.08e-21 | ||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 91.25 E-value: 1.08e-21
|
||||||||
Gla | pfam00594 | Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ... |
78-117 | 2.63e-21 | ||||
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla). Pssm-ID: 459861 Cd Length: 41 Bit Score: 87.20 E-value: 2.63e-21
|
||||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
200-231 | 6.42e-08 | ||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 6.42e-08
|
||||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
279-314 | 3.50e-06 | ||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 3.50e-06
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
189-232 | 3.91e-05 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 3.91e-05
|
||||||||
LamG | smart00282 | Laminin G domain; |
541-679 | 3.99e-05 | ||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 43.87 E-value: 3.99e-05
|
||||||||
vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
267-313 | 4.15e-05 | ||||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 45.45 E-value: 4.15e-05
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
189-222 | 6.49e-05 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 40.70 E-value: 6.49e-05
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
233-274 | 6.72e-05 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 6.72e-05
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
233-274 | 8.30e-05 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 40.31 E-value: 8.30e-05
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
275-315 | 6.51e-04 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 6.51e-04
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
151-187 | 8.71e-04 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 8.71e-04
|
||||||||
cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
258-278 | 1.38e-03 | ||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 36.62 E-value: 1.38e-03
|
||||||||
LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
514-677 | 3.02e-03 | ||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 38.94 E-value: 3.02e-03
|
||||||||
Name | Accession | Description | Interval | E-value | ||||
Laminin_G_1 | pfam00054 | Laminin G domain; |
361-491 | 1.42e-37 | ||||
Laminin G domain; Pssm-ID: 395008 [Multi-domain] Cd Length: 131 Bit Score: 136.29 E-value: 1.42e-37
|
||||||||
GLA | smart00069 | Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ... |
58-117 | 2.92e-27 | ||||
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration. Pssm-ID: 214503 Cd Length: 65 Bit Score: 104.70 E-value: 2.92e-27
|
||||||||
LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
344-487 | 1.12e-24 | ||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 100.57 E-value: 1.12e-24
|
||||||||
LamG | smart00282 | Laminin G domain; |
356-487 | 1.08e-21 | ||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 91.25 E-value: 1.08e-21
|
||||||||
Gla | pfam00594 | Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ... |
78-117 | 2.63e-21 | ||||
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla). Pssm-ID: 459861 Cd Length: 41 Bit Score: 87.20 E-value: 2.63e-21
|
||||||||
Laminin_G_2 | pfam02210 | Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ... |
361-487 | 1.10e-11 | ||||
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily. Pssm-ID: 460494 [Multi-domain] Cd Length: 126 Bit Score: 62.44 E-value: 1.10e-11
|
||||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
200-231 | 6.42e-08 | ||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 48.78 E-value: 6.42e-08
|
||||||||
FXa_inhibition | pfam14670 | Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ... |
279-314 | 3.50e-06 | ||||
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442. Pssm-ID: 464251 [Multi-domain] Cd Length: 36 Bit Score: 44.16 E-value: 3.50e-06
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
189-232 | 3.91e-05 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 41.08 E-value: 3.91e-05
|
||||||||
LamG | smart00282 | Laminin G domain; |
541-679 | 3.99e-05 | ||||
Laminin G domain; Pssm-ID: 214598 [Multi-domain] Cd Length: 132 Bit Score: 43.87 E-value: 3.99e-05
|
||||||||
vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
267-313 | 4.15e-05 | ||||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 45.45 E-value: 4.15e-05
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
189-222 | 6.49e-05 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 40.70 E-value: 6.49e-05
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
233-274 | 6.72e-05 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 40.69 E-value: 6.72e-05
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
233-274 | 8.30e-05 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 40.31 E-value: 8.30e-05
|
||||||||
EGF_CA | smart00179 | Calcium-binding EGF-like domain; |
275-315 | 6.51e-04 | ||||
Calcium-binding EGF-like domain; Pssm-ID: 214542 [Multi-domain] Cd Length: 39 Bit Score: 37.61 E-value: 6.51e-04
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
151-187 | 8.71e-04 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 37.23 E-value: 8.71e-04
|
||||||||
vWA_Matrilin | cd01475 | VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ... |
188-229 | 1.02e-03 | ||||
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands. Pssm-ID: 238752 [Multi-domain] Cd Length: 224 Bit Score: 41.22 E-value: 1.02e-03
|
||||||||
cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
258-278 | 1.38e-03 | ||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 36.62 E-value: 1.38e-03
|
||||||||
LamG | cd00110 | Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ... |
514-677 | 3.02e-03 | ||||
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules. Pssm-ID: 238058 [Multi-domain] Cd Length: 151 Bit Score: 38.94 E-value: 3.02e-03
|
||||||||
EGF_CA | cd00054 | Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ... |
275-315 | 3.04e-03 | ||||
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements. Pssm-ID: 238011 Cd Length: 38 Bit Score: 35.69 E-value: 3.04e-03
|
||||||||
EGF_CA | pfam07645 | Calcium-binding EGF domain; |
189-221 | 4.31e-03 | ||||
Calcium-binding EGF domain; Pssm-ID: 429571 Cd Length: 32 Bit Score: 35.29 E-value: 4.31e-03
|
||||||||
cEGF | pfam12662 | Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ... |
215-236 | 6.95e-03 | ||||
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue. Pssm-ID: 463661 Cd Length: 22 Bit Score: 34.31 E-value: 6.95e-03
|
||||||||
Blast search parameters | ||||
|