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Conserved domains on  [gi|936697130|ref|NP_001301006|]
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vitamin K-dependent protein S isoform 1 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
361-491 1.42e-37

Laminin G domain;


:

Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 136.29  E-value: 1.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130  361 FRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDIN 440
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 936697130  441 KP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 491
Cdd:pfam00054  81 SPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 58-117 2.92e-27

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


:

Pssm-ID: 214503  Cd Length: 65  Bit Score: 104.70  E-value: 2.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 936697130    58 FLSKQQASQVLVRKRRANS-LLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKY 117
Cdd:smart00069   4 FLSRQEANKVLRRQRRANAfLLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 200-231 6.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 6.42e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 936697130  200 NGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 231
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 279-314 3.50e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


:

Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 936697130  279 CSEN--MCAQLCVNYPGGYTCYCDgkKGFKLAQDQKSC 314
Cdd:pfam14670   1 CSVNngGCSHLCLNTPGGYTCSCP--EGYELQDDGRTC 36
LamG smart00282
Laminin G domain;
541-679 3.99e-05

Laminin G domain;


:

Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 43.87  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130   541 NVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTseksqdILLSVEN---TVIYRIQALSLCSDQQSHLEFRVNRNNLE 617
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGR------LVLRYDLgsgPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 936697130   618 LSTPLKIETISHEDLQRQLAVLDKAMkakvatYLGGLPDVP-FSATPVNAFYNGCME-VNINGV 679
Cdd:smart00282  75 LSVDGGNRVSGESPGGLTILNLDGPL------YLGGLPEDLkLPPLPVTPGFRGCIRnLKVNGK 132
EGF_CA smart00179
Calcium-binding EGF-like domain;
233-274 6.72e-05

Calcium-binding EGF-like domain;


:

Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 936697130   233 DVDECSLkPSICGT-AVCKNIPGDFECECPEGYRynlKSKSCE 274
Cdd:smart00179   1 DIDECAS-GNPCQNgGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 151-187 8.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


:

Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 8.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 936697130 151 DQCSPL-PCNEDGymSCKDGKASFTCTCKPGWQGEKCE 187
Cdd:cd00054    3 DECASGnPCQNGG--TCVNTVGSYRCSCPPGYTGRNCE 38
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
361-491 1.42e-37

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 136.29  E-value: 1.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130  361 FRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDIN 440
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 936697130  441 KP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 491
Cdd:pfam00054  81 SPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 58-117 2.92e-27

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 104.70  E-value: 2.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 936697130    58 FLSKQQASQVLVRKRRANS-LLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKY 117
Cdd:smart00069   4 FLSRQEANKVLRRQRRANAfLLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 344-487 1.12e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 1.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 344 YLKFRLPEISR--FSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVE 421
Cdd:cd00110    9 YVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVSVE 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 936697130 422 ELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRKVESELIkPINPRLDGCIRSWNL 487
Cdd:cd00110   89 RNGRSVTLSVDGERVVESGSPG---GSALLNLDGPLYLGGLPEDLKSPGL-PVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
356-487 1.08e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.25  E-value: 1.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130   356 SAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKN-EHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKE 434
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 936697130   435 AVMDINKPGplfKPENGLLETKVYFAGFPRkVESELIKPINPRLDGCIRSWNL 487
Cdd:smart00282  81 NRVSGESPG---GLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKV 129
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 78-117 2.63e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 87.20  E-value: 2.63e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 936697130   78 LEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKY 117
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 200-231 6.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 6.42e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 936697130  200 NGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 231
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 279-314 3.50e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 936697130  279 CSEN--MCAQLCVNYPGGYTCYCDgkKGFKLAQDQKSC 314
Cdd:pfam14670   1 CSVNngGCSHLCLNTPGGYTCSCP--EGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
189-232 3.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 3.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 936697130   189 DINECKDPSN-INGGcsqICDNTPGSYHCSCKNGFvmlSNKKDCK 232
Cdd:smart00179   1 DIDECASGNPcQNGG---TCVNTVGSYRCECPPGY---TDGRNCE 39
LamG smart00282
Laminin G domain;
541-679 3.99e-05

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 43.87  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130   541 NVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTseksqdILLSVEN---TVIYRIQALSLCSDQQSHLEFRVNRNNLE 617
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGR------LVLRYDLgsgPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 936697130   618 LSTPLKIETISHEDLQRQLAVLDKAMkakvatYLGGLPDVP-FSATPVNAFYNGCME-VNINGV 679
Cdd:smart00282  75 LSVDGGNRVSGESPGGLTILNLDGPL------YLGGLPEDLkLPPLPVTPGFRGCIRnLKVNGK 132
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 267-313 4.15e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 4.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 936697130 267 NLKSKSCEDIDECSE--NMCAQLCVNYPGGYTCYCdgKKGFKLAQDQKS 313
Cdd:cd01475  178 KFQGKICVVPDLCATlsHVCQQVCISTPGSYLCAC--TEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 189-222 6.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 6.49e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 936697130 189 DINECKDPSN-INGGcsqICDNTPGSYHCSCKNGF 222
Cdd:cd00054    1 DIDECASGNPcQNGG---TCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
233-274 6.72e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 936697130   233 DVDECSLkPSICGT-AVCKNIPGDFECECPEGYRynlKSKSCE 274
Cdd:smart00179   1 DIDECAS-GNPCQNgGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 233-274 8.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 8.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 936697130 233 DVDECSLkPSICG-TAVCKNIPGDFECECPEGYRYnlksKSCE 274
Cdd:cd00054    1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
275-315 6.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 6.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 936697130   275 DIDEC-SENMCAQ--LCVNYPGGYTCYCdgKKGFklaQDQKSCE 315
Cdd:smart00179   1 DIDECaSGNPCQNggTCVNTVGSYRCEC--PPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 151-187 8.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 8.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 936697130 151 DQCSPL-PCNEDGymSCKDGKASFTCTCKPGWQGEKCE 187
Cdd:cd00054    3 DECASGnPCQNGG--TCVNTVGSYRCSCPPGYTGRNCE 38
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 258-278 1.38e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|.
gi 936697130  258 CECPEGYRYNLKSKSCEDIDE 278
Cdd:pfam12662   2 CSCPPGYQLDPDGRTCVDIDE 22
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 514-677 3.02e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.94  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 514 GSYYPGSGIAQFhidynNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTseksqdILLSVENTV-IY 592
Cdd:cd00110    1 GVSFSGSSYVRL-----PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGR------LVLRYDLGSgSL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 593 RIQALSLCSDQQSH-LEFRVNRNNLELS-------TPLKIETISHEDLQRQLavldkamkakvatYLGGLPDVP-FSATP 663
Cdd:cd00110   70 VLSSKTPLNDGQWHsVSVERNGRSVTLSvdgervvESGSPGGSALLNLDGPL-------------YLGGLPEDLkSPGLP 136

                        170
                 ....*....|....*
gi 936697130 664 VNAFYNGCME-VNIN 677
Cdd:cd00110  137 VSPGFVGCIRdLKVN 151
 
Name Accession Description Interval E-value
Laminin_G_1 pfam00054
Laminin G domain;
361-491 1.42e-37

Laminin G domain;


Pssm-ID: 395008 [Multi-domain]  Cd Length: 131  Bit Score: 136.29  E-value: 1.42e-37
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130  361 FRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDIN 440
Cdd:pfam00054   1 FRTTEPSGLLLYNGTQTERDFLALELRDGRLEVSYDLGSGAAVVRSGDKLNDGKWHSVELERNGRSGTLSVDGEARPTGE 80

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|....
gi 936697130  441 KP-GPLFKPengLLETKVYFAGFPRKVESELIKPINPRLDGCIR--SWNLMKQG 491
Cdd:pfam00054  81 SPlGATTDL---DVDGPLYVGGLPSLGVKKRRLAISPSFDGCIRdvIVNGKPLD 131
GLA smart00069
Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in ...
 58-117 2.92e-27

Domain containing Gla (gamma-carboxyglutamate) residues; A hyaluronan-binding domain found in proteins associated with the extracellular matrix, cell adhesion and cell migration.


Pssm-ID: 214503  Cd Length: 65  Bit Score: 104.70  E-value: 2.92e-27
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 936697130    58 FLSKQQASQVLVRKRRANS-LLEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKY 117
Cdd:smart00069   4 FLSRQEANKVLRRQRRANAfLLEELRPGNLERECQEEICSLEEAREVFEDNEGTDEFYRRY 64
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 344-487 1.12e-24

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 100.57  E-value: 1.12e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 344 YLKFRLPEISR--FSAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKNEHTSKITTGGDVINNGLWNMVSVE 421
Cdd:cd00110    9 YVRLPTLPAPRtrLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGRLVLRYDLGSGSLVLSSKTPLNDGQWHSVSVE 88

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 936697130 422 ELEHSISIKIAKEAVMDINKPGplfKPENGLLETKVYFAGFPRKVESELIkPINPRLDGCIRSWNL 487
Cdd:cd00110   89 RNGRSVTLSVDGERVVESGSPG---GSALLNLDGPLYLGGLPEDLKSPGL-PVSPGFVGCIRDLKV 150
LamG smart00282
Laminin G domain;
356-487 1.08e-21

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 91.25  E-value: 1.08e-21
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130   356 SAEFDFRTYDSEGVILYAESIDHSAWLLIALRGGKIEVQLKN-EHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKE 434
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGRLVLRYDLgSGPARLTSDPTPLNDGQWHRVAVERNGRSVTLSVDGG 80

                           90       100       110       120       130
                   ....*....|....*....|....*....|....*....|....*....|...
gi 936697130   435 AVMDINKPGplfKPENGLLETKVYFAGFPRkVESELIKPINPRLDGCIRSWNL 487
Cdd:smart00282  81 NRVSGESPG---GLTILNLDGPLYLGGLPE-DLKLPPLPVTPGFRGCIRNLKV 129
Gla pfam00594
Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is ...
 78-117 2.63e-21

Vitamin K-dependent carboxylation/gamma-carboxyglutamic (GLA) domain; This domain is responsible for the high-affinity binding of calcium ions. This domain contains post-translational modifications of many glutamate residues by Vitamin K-dependent carboxylation to form gamma-carboxyglutamate (Gla).


Pssm-ID: 459861  Cd Length: 41  Bit Score: 87.20  E-value: 2.63e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 936697130   78 LEETKQGNLERECIEELCNKEEAREVFENDPETDYFYPKY 117
Cdd:pfam00594   1 LEELKPGNLERECYEEICSYEEAREIFEDDEKTMEFWKKY 40
Laminin_G_2 pfam02210
Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G ...
 361-487 1.10e-11

Laminin G domain; This family includes the Thrombospondin N-terminal-like domain, a Laminin G subfamily.


Pssm-ID: 460494 [Multi-domain]  Cd Length: 126  Bit Score: 62.44  E-value: 1.10e-11
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130  361 FRTYDSEGVILYAESIDHSaWLLIALRGGKIEVQLK-NEHTSKITTGGDVINNGLWNMVSVEELEHSISIKIAKEAVMDI 439
Cdd:pfam02210   1 FRTRQPNGLLLYAGGGGSD-FLALELVNGRLVLRYDlGSGPESLLSSGKNLNDGQWHSVRVERNGNTLTLSVDGQTVVSS 79

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 936697130  440 NKPGplfKPENGLLETKVYFAGFPrKVESELIKPINPRLDGCIRSWNL 487
Cdd:pfam02210  80 LPPG---ESLLLNLNGPLYLGGLP-PLLLLPALPVRAGFVGCIRDVRV 123
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 200-231 6.42e-08

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 48.78  E-value: 6.42e-08
                          10        20        30
                  ....*....|....*....|....*....|..
gi 936697130  200 NGGCSQICDNTPGSYHCSCKNGFVMLSNKKDC 231
Cdd:pfam14670   5 NGGCSHLCLNTPGGYTCSCPEGYELQDDGRTC 36
FXa_inhibition pfam14670
Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is ...
 279-314 3.50e-06

Coagulation Factor Xa inhibitory site; This short domain on coagulation enzyme factor Xa is found to be the target for a potent inhibitor of coagulation, TAK-442.


Pssm-ID: 464251 [Multi-domain]  Cd Length: 36  Bit Score: 44.16  E-value: 3.50e-06
                          10        20        30
                  ....*....|....*....|....*....|....*...
gi 936697130  279 CSEN--MCAQLCVNYPGGYTCYCDgkKGFKLAQDQKSC 314
Cdd:pfam14670   1 CSVNngGCSHLCLNTPGGYTCSCP--EGYELQDDGRTC 36
EGF_CA smart00179
Calcium-binding EGF-like domain;
189-232 3.91e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 41.08  E-value: 3.91e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 936697130   189 DINECKDPSN-INGGcsqICDNTPGSYHCSCKNGFvmlSNKKDCK 232
Cdd:smart00179   1 DIDECASGNPcQNGG---TCVNTVGSYRCECPPGY---TDGRNCE 39
LamG smart00282
Laminin G domain;
541-679 3.99e-05

Laminin G domain;


Pssm-ID: 214598 [Multi-domain]  Cd Length: 132  Bit Score: 43.87  E-value: 3.99e-05
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130   541 NVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTseksqdILLSVEN---TVIYRIQALSLCSDQQSHLEFRVNRNNLE 617
Cdd:smart00282   1 SISFSFRTTSPNGLLLYAGSKGGGDYLALELRDGR------LVLRYDLgsgPARLTSDPTPLNDGQWHRVAVERNGRSVT 74

                           90       100       110       120       130       140
                   ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 936697130   618 LSTPLKIETISHEDLQRQLAVLDKAMkakvatYLGGLPDVP-FSATPVNAFYNGCME-VNINGV 679
Cdd:smart00282  75 LSVDGGNRVSGESPGGLTILNLDGPL------YLGGLPEDLkLPPLPVTPGFRGCIRnLKVNGK 132
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 267-313 4.15e-05

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 45.45  E-value: 4.15e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*....
gi 936697130 267 NLKSKSCEDIDECSE--NMCAQLCVNYPGGYTCYCdgKKGFKLAQDQKS 313
Cdd:cd01475  178 KFQGKICVVPDLCATlsHVCQQVCISTPGSYLCAC--TEGYALLEDNKT 224
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 189-222 6.49e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.70  E-value: 6.49e-05
                         10        20        30
                 ....*....|....*....|....*....|....*
gi 936697130 189 DINECKDPSN-INGGcsqICDNTPGSYHCSCKNGF 222
Cdd:cd00054    1 DIDECASGNPcQNGG---TCVNTVGSYRCSCPPGY 32
EGF_CA smart00179
Calcium-binding EGF-like domain;
233-274 6.72e-05

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 40.69  E-value: 6.72e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 936697130   233 DVDECSLkPSICGT-AVCKNIPGDFECECPEGYRynlKSKSCE 274
Cdd:smart00179   1 DIDECAS-GNPCQNgGTCVNTVGSYRCECPPGYT---DGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 233-274 8.30e-05

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 40.31  E-value: 8.30e-05
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|...
gi 936697130 233 DVDECSLkPSICG-TAVCKNIPGDFECECPEGYRYnlksKSCE 274
Cdd:cd00054    1 DIDECAS-GNPCQnGGTCVNTVGSYRCSCPPGYTG----RNCE 38
EGF_CA smart00179
Calcium-binding EGF-like domain;
275-315 6.51e-04

Calcium-binding EGF-like domain;


Pssm-ID: 214542 [Multi-domain]  Cd Length: 39  Bit Score: 37.61  E-value: 6.51e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....
gi 936697130   275 DIDEC-SENMCAQ--LCVNYPGGYTCYCdgKKGFklaQDQKSCE 315
Cdd:smart00179   1 DIDECaSGNPCQNggTCVNTVGSYRCEC--PPGY---TDGRNCE 39
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 151-187 8.71e-04

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 37.23  E-value: 8.71e-04
                         10        20        30
                 ....*....|....*....|....*....|....*...
gi 936697130 151 DQCSPL-PCNEDGymSCKDGKASFTCTCKPGWQGEKCE 187
Cdd:cd00054    3 DECASGnPCQNGG--TCVNTVGSYRCSCPPGYTGRNCE 38
vWA_Matrilin cd01475
VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and ...
 188-229 1.02e-03

VWA_Matrilin: In cartilaginous plate, extracellular matrix molecules mediate cell-matrix and matrix-matrix interactions thereby providing tissue integrity. Some members of the matrilin family are expressed specifically in developing cartilage rudiments. The matrilin family consists of at least four members. All the members of the matrilin family contain VWA domains, EGF-like domains and a heptad repeat coiled-coiled domain at the carboxy terminus which is responsible for the oligomerization of the matrilins. The VWA domains have been shown to be essential for matrilin network formation by interacting with matrix ligands.


Pssm-ID: 238752 [Multi-domain]  Cd Length: 224  Bit Score: 41.22  E-value: 1.02e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 936697130 188 FDINECKDPS---NINGGCSQICDNTPGSYHCSCKNGFVMLSNKK 229
Cdd:cd01475  179 FQGKICVVPDlcaTLSHVCQQVCISTPGSYLCACTEGYALLEDNK 223
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 258-278 1.38e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 36.62  E-value: 1.38e-03
                          10        20
                  ....*....|....*....|.
gi 936697130  258 CECPEGYRYNLKSKSCEDIDE 278
Cdd:pfam12662   2 CSCPPGYQLDPDGRTCVDIDE 22
LamG cd00110
Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have ...
 514-677 3.02e-03

Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of purposes including signal transduction via cell-surface steroid receptors, adhesion, migration and differentiation through mediation of cell adhesion molecules.


Pssm-ID: 238058 [Multi-domain]  Cd Length: 151  Bit Score: 38.94  E-value: 3.02e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 514 GSYYPGSGIAQFhidynNVSSAEGWHVNVTLNIRPSTGTGVMLALVSGNNTVPFAVSLVDSTseksqdILLSVENTV-IY 592
Cdd:cd00110    1 GVSFSGSSYVRL-----PTLPAPRTRLSISFSFRTTSPNGLLLYAGSQNGGDFLALELEDGR------LVLRYDLGSgSL 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 936697130 593 RIQALSLCSDQQSH-LEFRVNRNNLELS-------TPLKIETISHEDLQRQLavldkamkakvatYLGGLPDVP-FSATP 663
Cdd:cd00110   70 VLSSKTPLNDGQWHsVSVERNGRSVTLSvdgervvESGSPGGSALLNLDGPL-------------YLGGLPEDLkSPGLP 136

                        170
                 ....*....|....*
gi 936697130 664 VNAFYNGCME-VNIN 677
Cdd:cd00110  137 VSPGFVGCIRdLKVN 151
EGF_CA cd00054
Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular ...
 275-315 3.04e-03

Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the N-terminus of particular EGF-like domains; calcium-binding may be crucial for numerous protein-protein interactions. Six conserved core cysteines form three disulfide bridges as in non calcium-binding EGF domains, whose structures are very similar. EGF_CA can be found in tandem repeat arrangements.


Pssm-ID: 238011  Cd Length: 38  Bit Score: 35.69  E-value: 3.04e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....
gi 936697130 275 DIDEC-SENMCA--QLCVNYPGGYTCYCDgkKGFKLaqdqKSCE 315
Cdd:cd00054    1 DIDECaSGNPCQngGTCVNTVGSYRCSCP--PGYTG----RNCE 38
EGF_CA pfam07645
Calcium-binding EGF domain;
189-221 4.31e-03

Calcium-binding EGF domain;


Pssm-ID: 429571  Cd Length: 32  Bit Score: 35.29  E-value: 4.31e-03
                          10        20        30
                  ....*....|....*....|....*....|....*
gi 936697130  189 DINECKDPSNInggCSQ--ICDNTPGSYHCSCKNG 221
Cdd:pfam07645   1 DVDECATGTHN---CPAntVCVNTIGSFECRCPDG 32
cEGF pfam12662
Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved ...
 215-236 6.95e-03

Complement Clr-like EGF-like; cEGF, or complement Clr-like EGF, domains have six conserved cysteine residues disulfide-bonded into the characteriztic pattern 'ababcc'. They are found in blood coagulation proteins such as fibrillin, Clr and Cls, thrombomodulin, and the LDL receptor. The core fold of the EGF domain consists of two small beta-hairpins packed against each other. Two major structural variants have been identified based on the structural context of the C-terminal cysteine residue of disulfide 'c' in the C-terminal hairpin: hEGFs and cEGFs. In cEGFs the C-terminal thiol resides on the C-terminal beta-sheet, resulting in long loop-lengths between the cysteine residues of disulfide 'c', typically C[10+]XC. These longer loop-lengths may have arisen by selective cysteine loss from a four-disulfide EGF template such as laminin or integrin. Tandem cEGF domains have five linking residues between terminal cysteines of adjacent domains. cEGF domains may or may not bind calcium in the linker region. cEGF domains with the consensus motif CXN4X[F,Y]XCXC are hydroxylated exclusively on the asparagine residue.


Pssm-ID: 463661  Cd Length: 22  Bit Score: 34.31  E-value: 6.95e-03
                          10        20
                  ....*....|....*....|..
gi 936697130  215 HCSCKNGFVMLSNKKDCKDVDE 236
Cdd:pfam12662   1 TCSCPPGYQLDPDGRTCVDIDE 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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