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Conserved domains on  [gi|902763190|ref|NP_001298016|]
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kelch domain-containing protein 10 isoform 2 [Mus musculus]

Protein Classification

Kelch repeat-containing protein( domain architecture ID 11459646)

Kelch repeat-containing protein, member of a superfamily of proteins with diverse functions

CATH:  2.120.10.80
Gene Ontology:  GO:0005515
PubMed:  10603472|31442578|24959344
SCOP:  3000448

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-369 6.32e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


:

Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  57 PPARSGHRCVADNTNLYVFGGYNpdydeSGGPDNEdyplfreLWRYHFATGVWHQMGTDGYMPRELASMslVLHGNNLLV 136
Cdd:COG3055   10 PTPRSEAAAALLDGKVYVAGGLS-----GGSASNS-------FEVYDPATNTWSELAPLPGPPRHHAAA--VAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 137 FGGTGIPFGESNG-NDVHVCNVKYKRWallSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQL 215
Cdd:COG3055   76 FGGFTGANPSSTPlNDVYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 216 KPnnlscdLPEERYRHE-IAHDGQRIYILGGGTSwtayslnkihayNLETNAWEEIATKPHekigfpaARRCHSCVQIKN 294
Cdd:COG3055  153 AP------LPTPRDHLAaAVLPDGKILVIGGRNG------------SGFSNTWTTLAPLPT-------ARAGHAAAVLGG 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 902763190 295 DVFICGGYNGevILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFKIWLV 369
Cdd:COG3055  208 KILVFGGESG--FSDEVEAYDPATNTWTALG-ELPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPLVTSA 273
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-369 6.32e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  57 PPARSGHRCVADNTNLYVFGGYNpdydeSGGPDNEdyplfreLWRYHFATGVWHQMGTDGYMPRELASMslVLHGNNLLV 136
Cdd:COG3055   10 PTPRSEAAAALLDGKVYVAGGLS-----GGSASNS-------FEVYDPATNTWSELAPLPGPPRHHAAA--VAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 137 FGGTGIPFGESNG-NDVHVCNVKYKRWallSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQL 215
Cdd:COG3055   76 FGGFTGANPSSTPlNDVYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 216 KPnnlscdLPEERYRHE-IAHDGQRIYILGGGTSwtayslnkihayNLETNAWEEIATKPHekigfpaARRCHSCVQIKN 294
Cdd:COG3055  153 AP------LPTPRDHLAaAVLPDGKILVIGGRNG------------SGFSNTWTTLAPLPT-------ARAGHAAAVLGG 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 902763190 295 DVFICGGYNGevILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFKIWLV 369
Cdd:COG3055  208 KILVFGGESG--FSDEVEAYDPATNTWTALG-ELPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPLVTSA 273
PLN02153 PLN02153
epithiospecifier protein
 107-270 5.79e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.39  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 107 GVW---HQMGTDGYMPRELASMSLVlhGNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKRPS-RIYGQAMAL 182
Cdd:PLN02153   7 GGWikvEQKGGKGPGPRCSHGIAVV--GDKLYSFGGELKP-NEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 183 INGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDlPEERYRHEIAHDGQRIYILG----GGTSWTAYSLNKIH 258
Cdd:PLN02153  84 VGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGgvskGGLMKTPERFRTIE 162

                        170
                 ....*....|..
gi 902763190 259 AYNLETNAWEEI 270
Cdd:PLN02153 163 AYNIADGKWVQL 174
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 283-329 5.29e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 5.29e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 902763190  283 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 329
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
Kelch smart00612
Kelch domain;
296-340 1.11e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 902763190   296 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 340
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
 
Name Accession Description Interval E-value
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
57-369 6.32e-27

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 108.70  E-value: 6.32e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  57 PPARSGHRCVADNTNLYVFGGYNpdydeSGGPDNEdyplfreLWRYHFATGVWHQMGTDGYMPRELASMslVLHGNNLLV 136
Cdd:COG3055   10 PTPRSEAAAALLDGKVYVAGGLS-----GGSASNS-------FEVYDPATNTWSELAPLPGPPRHHAAA--VAQDGKLYV 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 137 FGGTGIPFGESNG-NDVHVCNVKYKRWallSCRGKRPSRIYGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQL 215
Cdd:COG3055   76 FGGFTGANPSSTPlNDVYVYDPATNTW---TKLAPMPTPRGGATALLLDGKIYVVGGWDDGGNVAWVEVYDPATGTWTQL 152

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 216 KPnnlscdLPEERYRHE-IAHDGQRIYILGGGTSwtayslnkihayNLETNAWEEIATKPHekigfpaARRCHSCVQIKN 294
Cdd:COG3055  153 AP------LPTPRDHLAaAVLPDGKILVIGGRNG------------SGFSNTWTTLAPLPT-------ARAGHAAAVLGG 207

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 902763190 295 DVFICGGYNGevILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGvvnihENKRTGSLFKIWLV 369
Cdd:COG3055  208 KILVFGGESG--FSDEVEAYDPATNTWTALG-ELPTPRHGH-AAVLTDGKVYVIGG-----ETKPGVRTPLVTSA 273
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
56-303 6.91e-26

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 105.62  E-value: 6.91e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  56 PPPARSGHRCVADNTNLYVFGGYNPDYDESGgpdnedypLFRELWRYHFATGVWHQMGTdgyMPRELASMSLVLHGNNLL 135
Cdd:COG3055   57 PGPPRHHAAAVAQDGKLYVFGGFTGANPSST--------PLNDVYVYDPATNTWTKLAP---MPTPRGGATALLLDGKIY 125

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 136 VFGGTGipfGESNGNDVHVCNVKYKRW-ALLSCRGKRPSRiygQAMALINGSLYVFGGTTGYIYSTdlhkldlntmVWTQ 214
Cdd:COG3055  126 VVGGWD---DGGNVAWVEVYDPATGTWtQLAPLPTPRDHL---AAAVLPDGKILVIGGRNGSGFSN----------TWTT 189

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 215 LKPnnlscdLPEERYRHEIAHDGQRIYILGGGTSWtaysLNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQIKN 294
Cdd:COG3055  190 LAP------LPTARAGHAAAVLGGKILVFGGESGF----SDEVEAYDPATNTWTALGE-------LPTPRHGHAAVLTDG 252


                 ....*....
gi 902763190 295 DVFICGGYN 303
Cdd:COG3055  253 KVYVIGGET 261
NanM COG3055
N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];
212-358 4.15e-14

N-acetylneuraminic acid mutarotase [Cell wall/membrane/envelope biogenesis];


Pssm-ID: 442289 [Multi-domain]  Cd Length: 277  Bit Score: 72.11  E-value: 4.15e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 212 WTQLKpnnlscDLPEERYRHEIAHDGQRIYILGGGTSWTAysLNKIHAYNLETNAWEEIATkphekigFPAARRCHSCVQ 291
Cdd:COG3055    3 WSSLP------DLPTPRSEAAAALLDGKVYVAGGLSGGSA--SNSFEVYDPATNTWSELAP-------LPGPPRHHAAAV 67

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 902763190 292 -IKNDVFICGGYNG----EVILGDIWKLNLQTFQWVKLPaTMPEPVYFHcAAVTPAGCMYIHGGVVNIHENK 358
Cdd:COG3055   68 aQDGKLYVFGGFTGanpsSTPLNDVYVYDPATNTWTKLA-PMPTPRGGA-TALLLDGKIYVVGGWDDGGNVA 137
PLN02153 PLN02153
epithiospecifier protein
 107-270 5.79e-10

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 60.39  E-value: 5.79e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 107 GVW---HQMGTDGYMPRELASMSLVlhGNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKRPS-RIYGQAMAL 182
Cdd:PLN02153   7 GGWikvEQKGGKGPGPRCSHGIAVV--GDKLYSFGGELKP-NEHIDKDLYVFDFNTHTWSIAPANGDVPRiSCLGVRMVA 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 183 INGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNLSCDlPEERYRHEIAHDGQRIYILG----GGTSWTAYSLNKIH 258
Cdd:PLN02153  84 VGTKLYIFGGRDEKREFSDFYSYDTVKNEWTFLTKLDEEGG-PEARTFHSMASDENHVYVFGgvskGGLMKTPERFRTIE 162

                        170
                 ....*....|..
gi 902763190 259 AYNLETNAWEEI 270
Cdd:PLN02153 163 AYNIADGKWVQL 174
PLN02193 PLN02193
nitrile-specifier protein
 107-304 2.49e-09

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 58.81  E-value: 2.49e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 107 GVWHQMGTDGYMPRELASMSLVLHGNNLLVFGGTGIPfGESNGNDVHVCNVKYKRWALLSCRGKRPS-RIYGQAMALING 185
Cdd:PLN02193 151 GKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGEFTP-NQPIDKHLYVFDLETRTWSISPATGDVPHlSCLGVRMVSIGS 229

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 186 SLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNNlscDLPEERYRHEIAHDGQRIYILgGGTSWTAySLNKIHAYNLETN 265
Cdd:PLN02193 230 TLYVFGGRDASRQYNGFYSFDTTTNEWKLLTPVE---EGPTPRSFHSMAADEENVYVF-GGVSATA-RLKTLDSYNIVDK 304

                        170       180       190
                 ....*....|....*....|....*....|....*....
gi 902763190 266 AWEEIATkPHEKIgfpAARRCHSCVQIKNDVFICGGYNG 304
Cdd:PLN02193 305 KWFHCST-PGDSF---SIRGGAGLEVVQGKVWVVYGFNG 339
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 283-329 5.29e-08

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 48.76  E-value: 5.29e-08
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 902763190  283 ARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWVKLPaTMP 329
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLP-SMP 46
PLN02153 PLN02153
epithiospecifier protein
 169-325 1.31e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 53.07  E-value: 1.31e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 169 GKRPSRIYGQAMALINGSLYVFGG--TTGYIYSTDLHKLDLNTMVWTQLKPNNlscDLPE-ERYRHEIAHDGQRIYILGG 245
Cdd:PLN02153  17 GKGPGPRCSHGIAVVGDKLYSFGGelKPNEHIDKDLYVFDFNTHTWSIAPANG---DVPRiSCLGVRMVAVGTKLYIFGG 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 246 GTSWTAYslNKIHAYNLETNAWEeIATKPHEKiGFPAARRCHSCVQIKNDVFICGGYNGEVILG------DIWKLNLQTF 319
Cdd:PLN02153  94 RDEKREF--SDFYSYDTVKNEWT-FLTKLDEE-GGPEARTFHSMASDENHVYVFGGVSKGGLMKtperfrTIEAYNIADG 169


                 ....*.
gi 902763190 320 QWVKLP 325
Cdd:PLN02153 170 KWVQLP 175
Kelch_4 pfam13418
Galactose oxidase, central domain;
283-330 1.89e-07

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 47.22  E-value: 1.89e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 902763190  283 ARRCHSCVQIKND-VFICGGYNGE-VILGDIWKLNLQTFQWVKLPaTMPE 330
Cdd:pfam13418   1 PRAYHTSTSIPDDtIYLFGGEGEDgTLLSDLWVFDLSTNEWTRLG-SLPS 49
Kelch_3 pfam13415
Galactose oxidase, central domain;
237-292 4.51e-07

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 46.13  E-value: 4.51e-07
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 902763190  237 GQRIYILGGGTSWTAYSLNKIHAYNLETNAWEEIATKphekigfPAARRCHSCVQI 292
Cdd:pfam13415   1 GDKLYIFGGLGFDGQTRLNDLYVYDLDTNTWTQIGDL-------PPPRSGHSATYI 49
PLN02153 PLN02153
epithiospecifier protein
 57-226 5.66e-07

epithiospecifier protein


Pssm-ID: 177814 [Multi-domain]  Cd Length: 341  Bit Score: 51.14  E-value: 5.66e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  57 PPARSGHRCVADNTNLYVFGGYNpdydeSGGPDNEDyPLFRELWRYHFATGVWHQMGTDG--YMPRELASMsLVLHGNNL 134
Cdd:PLN02153 125 PEARTFHSMASDENHVYVFGGVS-----KGGLMKTP-ERFRTIEAYNIADGKWVQLPDPGenFEKRGGAGF-AVVQGKIW 197

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 135 LVFG--GTGIPFGESN--GNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTT-----GYI----YSTD 201
Cdd:PLN02153 198 VVYGfaTSILPGGKSDyeSNAVQFFDPASGKWTEVETTGAKPSARSVFAHAVVGKYIIIFGGEVwpdlkGHLgpgtLSNE 277

                        170       180
                 ....*....|....*....|....*
gi 902763190 202 LHKLDLNTMVWTQLKpnnlSCDLPE 226
Cdd:PLN02153 278 GYALDTETLVWEKLG----ECGEPA 298
PHA03098 PHA03098
kelch-like protein; Provisional
 176-321 6.15e-07

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 51.31  E-value: 6.15e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 176 YGQAMALINGSLYVFGGTTGYIYSTD-LHKLDLNTMVWTQLKPnnlscdLPEERYRHEIAHDGQRIYILGGGTSWTAYS- 253
Cdd:PHA03098 381 YNPCVVNVNNLIYVIGGISKNDELLKtVECFSLNTNKWSKGSP------LPISHYGGCAIYHDGKIYVIGGISYIDNIKv 454

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 902763190 254 LNKIHAYNLETNAWEEIATKPHEKIGfpaarrcHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQW 321
Cdd:PHA03098 455 YNIVESYNPVTNKWTELSSLNFPRIN-------ASLCIFNNKIYVVGGDKYEYYINEIEVYDDKTNTW 515
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 228-274 3.52e-06

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 43.75  E-value: 3.52e-06
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*..
gi 902763190  228 RYRHEIAHDGQRIYILGGGTSWTaySLNKIHAYNLETNAWEEIATKP 274
Cdd:pfam01344   2 RSGAGVVVVGGKIYVIGGFDGNQ--SLNSVEVYDPETNTWSKLPSMP 46
PLN02193 PLN02193
nitrile-specifier protein
 127-350 6.18e-06

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 48.03  E-value: 6.18e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 127 LVLHGNNLLVFGGTGIPFGESNGNDVHVCNVK--YKRWALLSCRGKRPSRIYGQAMALINGSLYVFGG--TTGYIYSTDL 202
Cdd:PLN02193 116 FVLQGGKIVGFHGRSTDVLHSLGAYISLPSTPklLGKWIKVEQKGEGPGLRCSHGIAQVGNKIYSFGGefTPNQPIDKHL 195

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 203 HKLDLNTMVWTqLKPN-----NLSCdlpeerYRHEIAHDGQRIYILGGGTSWTAYslNKIHAYNLETNAWEEIAtkPHEK 277
Cdd:PLN02193 196 YVFDLETRTWS-ISPAtgdvpHLSC------LGVRMVSIGSTLYVFGGRDASRQY--NGFYSFDTTTNEWKLLT--PVEE 264

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 902763190 278 igFPAARRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTFQWvklpatmpepvyFHCAavTPAGCMYIHGG 350
Cdd:PLN02193 265 --GPTPRSFHSMAADEENVYVFGGVSATARLKTLDSYNIVDKKW------------FHCS--TPGDSFSIRGG 321
PHA03098 PHA03098
kelch-like protein; Provisional
 59-268 1.41e-05

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 47.07  E-value: 1.41e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  59 ARSGHRCVADNTNLYVFGGYnpdydesggpDNEDYPLFRELWRyhFATGVWhQMGTDGYMPRelASMSLVLHGNNLLVFG 138
Cdd:PHA03098 332 PRKNPGVTVFNNRIYVIGGI----------YNSISLNTVESWK--PGESKW-REEPPLIFPR--YNPCVVNVNNLIYVIG 396

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 139 GtgIPFGESNGNDVHVCNVKYKRWALLSCRgkrPSRIYGQAMALINGSLYVFGGTTgyiYSTDLHKL------DLNTMVW 212
Cdd:PHA03098 397 G--ISKNDELLKTVECFSLNTNKWSKGSPL---PISHYGGCAIYHDGKIYVIGGIS---YIDNIKVYnivesyNPVTNKW 468

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 902763190 213 TQLKPNNLScdlpeeRYRHEIAHDGQRIYILGGGTSwtAYSLNKIHAYNLETNAWE 268
Cdd:PHA03098 469 TELSSLNFP------RINASLCIFNNKIYVVGGDKY--EYYINEIEVYDDKTNTWT 516
Kelch_6 pfam13964
Kelch motif;
228-275 2.04e-05

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 41.55  E-value: 2.04e-05
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 902763190  228 RYRHEIAHDGQRIYILGGGTSWTAYSlNKIHAYNLETNAWEEIATKPH 275
Cdd:pfam13964   2 RTFHSVVSVGGYIYVFGGYTNASPAL-NKLEVYNPLTKSWEELPPLPT 48
PRK14131 PRK14131
N-acetylneuraminate epimerase;
234-351 2.63e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 46.16  E-value: 2.63e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 234 AHDGQRIYI-LG-GGTSWTAYSLNKIHAynletnAWEEIATkphekigFPAARRCHS-CVQIKNDVFICGGY-----NGE 305
Cdd:PRK14131  35 AIDNNTVYVgLGsAGTSWYKLDLNAPSK------GWTKIAA-------FPGGPREQAvAAFIDGKLYVFGGIgktnsEGS 101

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 902763190 306 VIL-GDIWKLNLQTFQWVKLPATMPEPVYFHcAAVTPAGCM-YIHGGV 351
Cdd:PRK14131 102 PQVfDDVYKYDPKTNSWQKLDTRSPVGLAGH-VAVSLHNGKaYITGGV 148
PRK14131 PRK14131
N-acetylneuraminate epimerase;
56-139 3.99e-05

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 45.39  E-value: 3.99e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  56 PPPARSGHRCVADNTNLYVFGGynpdydeSGGPDNEDYP-LFRELWRYHFATGVWHQMGTDGymPRELA-SMSLVLHGNN 133
Cdd:PRK14131  71 PGGPREQAVAAFIDGKLYVFGG-------IGKTNSEGSPqVFDDVYKYDPKTNSWQKLDTRS--PVGLAgHVAVSLHNGK 141


                 ....*.
gi 902763190 134 LLVFGG 139
Cdd:PRK14131 142 AYITGG 147
PLN02193 PLN02193
nitrile-specifier protein
 62-245 9.77e-05

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 44.56  E-value: 9.77e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  62 GHRCVADNTNLYVFGGYNPDYDESGgpdnedyplfreLWRYHFATGVWHQMG--TDGYMPRELASMSlvLHGNNLLVFGG 139
Cdd:PLN02193 221 GVRMVSIGSTLYVFGGRDASRQYNG------------FYSFDTTTNEWKLLTpvEEGPTPRSFHSMA--ADEENVYVFGG 286

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 140 TGipfGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGGTTGyIYSTDLHKLDLNTMVWTQLKPNN 219
Cdd:PLN02193 287 VS---ATARLKTLDSYNIVDKKWFHCSTPGDSFSIRGGAGLEVVQGKVWVVYGFNG-CEVDDVHYYDPVQDKWTQVETFG 362

                        170       180
                 ....*....|....*....|....*.
gi 902763190 220 LScdlPEERYRHEIAHDGQRIYILGG 245
Cdd:PLN02193 363 VR---PSERSVFASAAVGKHIVIFGG 385
Kelch smart00612
Kelch domain;
296-340 1.11e-04

Kelch domain;


Pssm-ID: 128874 [Multi-domain]  Cd Length: 47  Bit Score: 39.46  E-value: 1.11e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|....*
gi 902763190   296 VFICGGYNGEVILGDIWKLNLQTFQWVKLPAtMPEPVYFHCAAVT 340
Cdd:smart00612   2 IYVVGGFDGGQRLKSVEVYDPETNKWTPLPS-MPTPRSGHGVAVI 45
PHA03098 PHA03098
kelch-like protein; Provisional
 150-325 2.13e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 43.22  E-value: 2.13e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 150 NDVHVCNVKYKRWallscrGKRPSRIY---GQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPnnlscdLPE 226
Cdd:PHA03098 311 NSVVSYDTKTKSW------NKVPELIYprkNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGESKWREEPP------LIF 378

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 227 ERYRHEIAHDGQRIYILgGGTSWTAYSLNKIHAYNLETNAWEEIATKPHEKIGfpaarrcHSCVQIKNDVFICGGY---N 303
Cdd:PHA03098 379 PRYNPCVVNVNNLIYVI-GGISKNDELLKTVECFSLNTNKWSKGSPLPISHYG-------GCAIYHDGKIYVIGGIsyiD 450

                        170       180
                 ....*....|....*....|..
gi 902763190 304 GEVILGDIWKLNLQTFQWVKLP 325
Cdd:PHA03098 451 NIKVYNIVESYNPVTNKWTELS 472
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 225-265 2.38e-04

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 38.31  E-value: 2.38e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 902763190  225 PEERYRHEIAHDGQRIYILGGGTSWTAYSLNKIHAYNLETN 265
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQPSDDVYVLSLPTF 41
Kelch_4 pfam13418
Galactose oxidase, central domain;
59-114 3.86e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.98  E-value: 3.86e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*..
gi 902763190   59 ARSGHRCVA-DNTNLYVFGGYNpdydesggpdnEDYPLFRELWRYHFATGVWHQMGT 114
Cdd:pfam13418   1 PRAYHTSTSiPDDTIYLFGGEG-----------EDGTLLSDLWVFDLSTNEWTRLGS 46
Kelch_6 pfam13964
Kelch motif;
283-331 4.38e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.70  E-value: 4.38e-04
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 902763190  283 ARRCHSCVQIKNDVFICGGY-NGEVILGDIWKLNLQTFQWVKLPaTMPEP 331
Cdd:pfam13964   1 PRTFHSVVSVGGYIYVFGGYtNASPALNKLEVYNPLTKSWEELP-PLPTP 49
PHA03098 PHA03098
kelch-like protein; Provisional
 240-360 5.82e-04

kelch-like protein; Provisional


Pssm-ID: 222983 [Multi-domain]  Cd Length: 534  Bit Score: 42.06  E-value: 5.82e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 240 IYILGGGTSwTAYSLNKIHAYNLETNAWEEIAtkpheKIGFPaaRRCHSCVQIKNDVFICGGYNGEVILGDIWKLNLQTF 319
Cdd:PHA03098 297 IYFIGGMNK-NNLSVNSVVSYDTKTKSWNKVP-----ELIYP--RKNPGVTVFNNRIYVIGGIYNSISLNTVESWKPGES 368

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 902763190 320 QWVKLPaTMPEPVYFHCAAVTpAGCMYIHGGVVNIHENKRT 360
Cdd:PHA03098 369 KWREEP-PLIFPRYNPCVVNV-NNLIYVIGGISKNDELLKT 407
Kelch_4 pfam13418
Galactose oxidase, central domain;
233-275 5.90e-04

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 37.59  E-value: 5.90e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|...
gi 902763190  233 IAHDGQRIYILGGgTSWTAYSLNKIHAYNLETNAWEEIATKPH 275
Cdd:pfam13418   8 TSIPDDTIYLFGG-EGEDGTLLSDLWVFDLSTNEWTRLGSLPS 49
Kelch_6 pfam13964
Kelch motif;
177-215 6.43e-04

Kelch motif;


Pssm-ID: 404790 [Multi-domain]  Cd Length: 50  Bit Score: 37.31  E-value: 6.43e-04
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|
gi 902763190  177 GQAMALINGSLYVFGGTTGY-IYSTDLHKLDLNTMVWTQL 215
Cdd:pfam13964   4 FHSVVSVGGYIYVFGGYTNAsPALNKLEVYNPLTKSWEEL 43
PLN02193 PLN02193
nitrile-specifier protein
 52-192 7.05e-04

nitrile-specifier protein


Pssm-ID: 177844 [Multi-domain]  Cd Length: 470  Bit Score: 41.48  E-value: 7.05e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  52 PGHRPPPARSGHRCVADNTNLYVFGGYNPDydesggpdnedyPLFRELWRYHFATGVWHQMGT--DGYMPRELASMSlVL 129
Cdd:PLN02193 261 PVEEGPTPRSFHSMAADEENVYVFGGVSAT------------ARLKTLDSYNIVDKKWFHCSTpgDSFSIRGGAGLE-VV 327

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 902763190 130 HGNNLLVFGgtgipFGESNGNDVHVCNVKYKRWALLSCRGKRPSRIYGQAMALINGSLYVFGG 192
Cdd:PLN02193 328 QGKVWVVYG-----FNGCEVDDVHYYDPVQDKWTQVETFGVRPSERSVFASAAVGKHIVIFGG 385
Kelch_5 pfam13854
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 57-85 1.08e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 433528 [Multi-domain]  Cd Length: 41  Bit Score: 36.39  E-value: 1.08e-03
                          10        20
                  ....*....|....*....|....*....
gi 902763190   57 PPARSGHRCVADNTNLYVFGGYNPDYDES 85
Cdd:pfam13854   1 PVPRYGHCAVTVGDYIYLYGGYTGGEGQP 29
PRK14131 PRK14131
N-acetylneuraminate epimerase;
172-303 1.75e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 40.38  E-value: 1.75e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 172 PSRIYGQAMALINGSLYVFGGTTGyiysTDLHKLDLNTMV--WTQLKpnnlscDLP-EERYRHEIAHDGQRIYILGG-GT 247
Cdd:PRK14131  26 PVPFKNGTGAIDNNTVYVGLGSAG----TSWYKLDLNAPSkgWTKIA------AFPgGPREQAVAAFIDGKLYVFGGiGK 95

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190 248 SWTAYSL---NKIHAYNLETNAWEEIATKPhekigfPAARRCHSCVQIKND-VFICGGYN 303
Cdd:PRK14131  96 TNSEGSPqvfDDVYKYDPKTNSWQKLDTRS------PVGLAGHVAVSLHNGkAYITGGVN 149
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 59-114 3.54e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 35.28  E-value: 3.54e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 902763190   59 ARSGHRCVADNTNLYVFGGYNPDydesggpdnedyPLFRELWRYHFATGVWHQMGT 114
Cdd:pfam01344   1 RRSGAGVVVVGGKIYVIGGFDGN------------QSLNSVEVYDPETNTWSKLPS 44
Kelch_2 pfam07646
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 176-217 3.71e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 462220 [Multi-domain]  Cd Length: 47  Bit Score: 35.00  E-value: 3.71e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 902763190  176 YGQAMALINGSLYVFGGTTGY--IYSTDLHKLDLNTMVWTQLKP 217
Cdd:pfam07646   3 YPHASSVPGGKLYVVGGSDGLgdLSSSDVLVYDPETNVWTEVPR 46
Kelch_4 pfam13418
Galactose oxidase, central domain;
174-217 5.64e-03

Galactose oxidase, central domain;


Pssm-ID: 433191 [Multi-domain]  Cd Length: 49  Bit Score: 34.51  E-value: 5.64e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*.
gi 902763190  174 RIYGQAMALINGSLYVFGGTT--GYIYStDLHKLDLNTMVWTQLKP 217
Cdd:pfam13418   2 RAYHTSTSIPDDTIYLFGGEGedGTLLS-DLWVFDLSTNEWTRLGS 46
Kelch_1 pfam01344
Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six ...
 176-219 5.68e-03

Kelch motif; The kelch motif was initially discovered in Kelch. In this protein there are six copies of the motif. It has been shown that Swiss:Q04652 is related to Galactose Oxidase for which a structure has been solved. The kelch motif forms a beta sheet. Several of these sheets associate to form a beta propeller structure as found in pfam00064, pfam00400 and pfam00415.


Pssm-ID: 396078 [Multi-domain]  Cd Length: 46  Bit Score: 34.51  E-value: 5.68e-03
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....
gi 902763190  176 YGQAMALINGSLYVFGGTTGYIYSTDLHKLDLNTMVWTQLKPNN 219
Cdd:pfam01344   3 SGAGVVVVGGKIYVIGGFDGNQSLNSVEVYDPETNTWSKLPSMP 46
Kelch_3 pfam13415
Galactose oxidase, central domain;
184-231 5.78e-03

Galactose oxidase, central domain;


Pssm-ID: 433188 [Multi-domain]  Cd Length: 49  Bit Score: 34.57  E-value: 5.78e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|
gi 902763190  184 NGSLYVFGG--TTGYIYSTDLHKLDLNTMVWTQLKpnnlscDLPEERYRH 231
Cdd:pfam13415   1 GDKLYIFGGlgFDGQTRLNDLYVYDLDTNTWTQIG------DLPPPRSGH 44
PRK14131 PRK14131
N-acetylneuraminate epimerase;
55-139 8.49e-03

N-acetylneuraminate epimerase;


Pssm-ID: 237617 [Multi-domain]  Cd Length: 376  Bit Score: 38.07  E-value: 8.49e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 902763190  55 RPPPARSGHRCVA-DNTNLYVFGGYN--------PDYDESGGPDN--------------EDYPLFRELWRYHFATGVWHQ 111
Cdd:PRK14131 124 RSPVGLAGHVAVSlHNGKAYITGGVNknifdgyfEDLAAAGKDKTpkdkindayfdkkpEDYFFNKEVLSYDPSTNQWKN 203

                         90       100
                 ....*....|....*....|....*...
gi 902763190 112 MGTDGYMPRelASMSLVLHGNNLLVFGG 139
Cdd:PRK14131 204 AGESPFLGT--AGSAVVIKGNKLWLING 229
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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