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Conserved domains on  [gi|854281720|ref|NP_001297030|]
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large ribosomal subunit protein mL64 [Xenopus tropicalis]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
CR6_interact super family cl25690
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 39-199 4.16e-34

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


The actual alignment was detected with superfamily member pfam10147:

Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 120.73  E-value: 4.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720   39 PDPNDPDTkQWHKGAKYEAKLYGRHGDLSGVKPEGLWPSPEKLREIEEEEREWCPSVRDMLDNVEAKEREIERKKQEKER 118
Cdd:pfam10147  34 PPRRQPDS-WIQLTEKYARKQFGRYGAKSGVNPKSLFPSAEQLEELEAEEREWYPSLAQMLESNRAQKAEKEARRQAREQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720  119 LIAANLAKMPKMVADWRREKREAKQKQRDEKARKERLMAIARDKFGLNVDSRSPKFQEMVKELEKEEKKKQKAMKRRLKE 198
Cdd:pfam10147 113 EIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKEKEDKKKVKEAKRKEKE 192


                  .
gi 854281720  199 E 199
Cdd:pfam10147 193 E 193
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 39-199 4.16e-34

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 120.73  E-value: 4.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720   39 PDPNDPDTkQWHKGAKYEAKLYGRHGDLSGVKPEGLWPSPEKLREIEEEEREWCPSVRDMLDNVEAKEREIERKKQEKER 118
Cdd:pfam10147  34 PPRRQPDS-WIQLTEKYARKQFGRYGAKSGVNPKSLFPSAEQLEELEAEEREWYPSLAQMLESNRAQKAEKEARRQAREQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720  119 LIAANLAKMPKMVADWRREKREAKQKQRDEKARKERLMAIARDKFGLNVDSRSPKFQEMVKELEKEEKKKQKAMKRRLKE 198
Cdd:pfam10147 113 EIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKEKEDKKKVKEAKRKEKE 192


                  .
gi 854281720  199 E 199
Cdd:pfam10147 193 E 193
 
Name Accession Description Interval E-value
CR6_interact pfam10147
Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family ...
 39-199 4.16e-34

Growth arrest and DNA-damage-inducible proteins-interacting protein 1; Members of this family of proteins act as negative regulators of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occur also in the absence of GADD45 proteins. Furthermore, they act as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity.


Pssm-ID: 431088 [Multi-domain]  Cd Length: 204  Bit Score: 120.73  E-value: 4.16e-34
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720   39 PDPNDPDTkQWHKGAKYEAKLYGRHGDLSGVKPEGLWPSPEKLREIEEEEREWCPSVRDMLDNVEAKEREIERKKQEKER 118
Cdd:pfam10147  34 PPRRQPDS-WIQLTEKYARKQFGRYGAKSGVNPKSLFPSAEQLEELEAEEREWYPSLAQMLESNRAQKAEKEARRQAREQ 112

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720  119 LIAANLAKMPKMVADWRREKREAKQKQRDEKARKERLMAIARDKFGLNVDSRSPKFQEMVKELEKEEKKKQKAMKRRLKE 198
Cdd:pfam10147 113 EIAKKMAKMPQWIADWNAQKAKREAEAQAAKERKERLVAEAREHFGFKVDPRDERFKEMLQQKEKEDKKKVKEAKRKEKE 192


                  .
gi 854281720  199 E 199
Cdd:pfam10147 193 E 193
TAF4 pfam05236
Transcription initiation factor TFIID component TAF4 family; This region of similarity is ...
 95-173 7.05e-05

Transcription initiation factor TFIID component TAF4 family; This region of similarity is found in Transcription initiation factor TFIID component TAF4.


Pssm-ID: 461598 [Multi-domain]  Cd Length: 264  Bit Score: 42.64  E-value: 7.05e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 854281720   95 VRDMLDNVEAKEREIERKKQEKERLIAANLAKMPKMVADWRREKREAK----QKQRDEKARKE------RLMAIARDKFG 164
Cdd:pfam05236 112 VRKQLKFLAQKDKEEEERRVAEEREGLLKAAKSRSNQEDPEQLKLKQEakemQKEEDEKMRHRaanltaLAAIGPRKKKY 191


                  ....*....
gi 854281720  165 LNVDSRSPK 173
Cdd:pfam05236 192 SWMSSSASG 200
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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