|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
25-1440 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1659.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 25 KRLSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFD-EDTGMNCRDITFVPGLYKIFDEILVNAADNKQRDKT--- 100
Cdd:PTZ00108 2 KNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDeEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghr 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 101 MNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVET 180
Cdd:PTZ00108 82 MTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVEC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 181 ACRESKRCFKQTWFDNMGRAGESKIKPFDG-DDYTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAGSTKGVRVLLNGK 259
Cdd:PTZ00108 162 VDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNGE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 260 RLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEV 339
Cdd:PTZ00108 242 RIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQEK 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 340 VKKKNKAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQ 419
Cdd:PTZ00108 322 AKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKLA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 420 AQLNKKCSAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQ 499
Cdd:PTZ00108 402 AELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLKQ 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 500 IMENAEINNIIKILGLQYKKNYSDPeslKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHN-FLEEFITPIIK 578
Cdd:PTZ00108 482 LMNNKEIQNLFKILGLDIGKKYEDP---KGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIVK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 579 ASNK-KQEISFYSIPEFTEWKEKQsSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMI 657
Cdd:PTZ00108 559 ATKKgNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKRV 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 658 EERKEWLTSFMinrrqrrehnlPEEYLyGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDGLKPGQRKVVFCCFKRND 737
Cdd:PTZ00108 638 EDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRNL 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 738 KREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLF 817
Cdd:PTZ00108 706 KNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYIF 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 818 PVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGT 897
Cdd:PTZ00108 786 PEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKGT 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 898 IDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKEnVLEVMLNGTEkvpALITDYKEYHTDTTVRFVVKMTEERLR 977
Cdd:PTZ00108 866 IERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLESETLKEK---DVIVDYRDYSTANTVHFTVKLNDGVLE 941
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 978 EAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEK 1057
Cdd:PTZ00108 942 QWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKHV 1021
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1058 IQGTLVIENKPKKELIRMLQQMGYDS-------DPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTK 1130
Cdd:PTZ00108 1022 INGELVITNAKKKDLVKELKKLGYVRfkdiikkKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPIWSLTK 1101
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1131 EKKDELCKQRDAKMTELNTLKMKAPADLWKEDLAAFTEELERVEQKEKESQNamplvkgkvgkpkvvkvknetmptpQGR 1210
Cdd:PTZ00108 1102 EKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIA-------------------------KEQ 1156
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1211 RVIPRITSTMKVQAVKKERGKGSKKEAGLVMKmefddeadaAADGTGVGLAARLTKKIKKEPTKDKGSKSGKQTTltfkp 1290
Cdd:PTZ00108 1157 RLKSKTKGKASKLRKPKLKKKEKKKKKSSADK---------SKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSG----- 1222
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1291 vqkknpwSSDEGESDSDLELMSEETAPREKRERRAAVEKKYSLSSSEDEFDDFTKSS-KTKRAVIEDDESFNPEPSAAPD 1369
Cdd:PTZ00108 1223 -------SDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKnAPKRVSAVQYSPPPPSKRPDGE 1295
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 842062861 1370 SDVDSppppvvkkAPTKVAKAKAEKPEASSKSSSHSEASQEPAPKPVKKTAEGAAKKPPAKMTSAVSKKKA 1440
Cdd:PTZ00108 1296 SNGGS--------KPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRK 1358
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
79-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 772.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 79 GLYKIFDEILVNAADNKQRDKtMNCIKVNIDPENnTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 158
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 159 GGRNGYGAKLCNIFSLKFTVETACResKRCFKQTWFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMqaLDKDTVALL 238
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGM--TTDDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 239 TRRAYDIAGSTKGVRVLLNGKR-------LPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKG-FQQV 310
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 311 SFVNSIATTKGGRHTDYVADQIVSKLIEVVKKKNKAGVA-VKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGS 389
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 390 A-----CSLSDKFVKQANGCGIVESIMNWVKFKAQAQ-LNKKCSAVKHTKIKGVPKLDDANDAGGKNsnsCTLILTEGDS 463
Cdd:smart00433 315 EkivseCLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPKK---CELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 464 AKTLAVSGLgvvGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYsdpeSLKSLRYGKLMIMTDQDQ 543
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 544 DGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKQ--EISFYSIPEFTEWKEKQSSIK-SWKIKYYKGLGTSTS 620
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 842062861 621 KEAKEYFSDMTRHRIPFKYSGPADD-EAITLAFSKKMIEERKEWLTSFM 668
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEaDLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
710-1166 |
8.30e-154 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 475.52 E-value: 8.30e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 710 NERSIPCMVDGLKPGQRKVVFCCFKRN---DKREVKVAQLAGSVAEMSaYHHGEVSLMMTIVGLAQNFvgSNNLNLLQPL 786
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 787 GQFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNlRVEPEWYMPIIPLVLANGGEGIGTGWASRIP 864
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFvpNYDGQ-EVEPEVLPPIFPNLLVNGSSGIAVGMATNIP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 865 NYDVREIINNIHRMLNGEEP-------LPMLPSYKGFkGTIDELA---------KNQYVNNGEVAIIDS---TTIEITEL 925
Cdd:cd00187 155 PHNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEDDegrNTIEITEL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 926 PVKTWTQTYKENVLEVMLNGTEkvpALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNsMVLFDHV 1005
Cdd:cd00187 234 PYQVNKAKLKEKIAELVKDKKI---EGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1006 GSLKKYeSVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILE--KIQGTLVIENKPKKELIRMLQQMGYDS 1083
Cdd:cd00187 310 GRPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1084 DpvkawkdaqekeeeedaedddekekedtsgpDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLK-----MKAPADL 1158
Cdd:cd00187 389 I-------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEkilasEERPKDL 437
|
....*...
gi 842062861 1159 WKEDLAAF 1166
Cdd:cd00187 438 WKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
712-1163 |
1.22e-142 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 445.07 E-value: 1.22e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 712 RSIPCMVDGLKPGQRKVVFCCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFVGsnNLNLLQPLGQ 788
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 789 FGTRLHGGKDsASPRYIFTMLSTLARLLFPVVDDNLLKYNYD-DNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYD 867
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 868 VREIINNIHRMLNGEEP-----LPMLPSYKGFKGTIDELA--------KNQYVNNGEVAIIDSTTIEITELPVKTWTQTY 934
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGikeayktgRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 935 KENVLEvmLNGTEKVPaLITDYKEYhTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVgslKKYESV 1014
Cdd:pfam00521 236 IEKIEE--LVKNGKIK-GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1015 QDILKEFFELRMKYYVLRKDWLVGMLGAESAKLS------NQARFILEKIQGTLViENKPKKELIRMLQQMgydsdpvka 1088
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSID-RKKAKKNLIEELSEI--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1089 wkdaqekeeeedaedddekekedtsgpDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKM-----KAPADLWKEDL 1163
Cdd:pfam00521 379 ---------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKllaseKKLNDLWIEEL 431
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
39-616 |
2.52e-37 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 150.56 E-value: 2.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 39 LEHILLRPDTYIGSVepvtqqmwvfDEDtgmncrditfvpGLYKIFDEILVNA--------ADNkqrdktmncIKVNIDp 110
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 111 ENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETAcRESKRcFK 190
Cdd:COG0187 65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RDGKI-YR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 191 QTwFDNmGRAGES--KIKPFD--GddyTCITFQPDLAKFKMQALDKDTvalLTRRAYDIAGSTKGVRVLLNGKRlpINNF 266
Cdd:COG0187 143 QR-FER-GKPVGPleKIGKTDrtG---TTVRFKPDPEIFETTEFDYET---LAERLRELAFLNKGLTITLTDER--EEEP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 267 RTYVDLY---VKDKVDETGSPLTVVHEMV--------NERWEVCLTLSEKGFQQV-SFVNSIATTKGGRH---------- 324
Cdd:COG0187 213 KEETFHYeggIKDFVEYLNEDKEPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHetgfrtaltr 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 325 --TDYvADQivSKLIevvKKKNK--------AG-VAVkpfqvknhmwlfVNCLIENPSFDSQTKEnmtlqqknfgsacSL 393
Cdd:COG0187 293 viNDY-ARK--NGLL---KEKDKnltgddvrEGlTAV------------ISVKLPEPQFEGQTKT-------------KL 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 394 SDKFVKqangcGIVES-------------------IMNWVKFKAQAQLnkkcSAVKH---TKIKGVpkLDDAN------D 445
Cdd:COG0187 342 GNSEAR-----GIVESvvseklehyleenpaeakkILEKAILAARARE----AARKArelVRRKSA--LESSGlpgklaD 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 446 AGGKNSNSCTLILTEGDSA----KTlavsglgvvGRDRY--GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKK 519
Cdd:COG0187 411 CSSKDPEESELFIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGD 481
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 520 NYsdpeSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLeeFI--TPIIKASNKKQEISFYSIPEFTEW 597
Cdd:COG0187 482 DF----DLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDEL 555
|
650
....*....|....*....
gi 842062861 598 KEKQSSIKSWKIKYYKGLG 616
Cdd:COG0187 556 LKELKGKKKVEIQRYKGLG 574
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
712-1033 |
1.93e-16 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 85.44 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 712 RSIPCMVDGLKPGQRKVVFCCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgSNNLNLLQPLG 787
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 788 QFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNLRvEPEWYMPIIPLVLANGGEGIGTGWASRIPN 865
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFvpNYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 866 YDVREIINNIHRMLNGEE----------PLPMLP-------------SYKGFKGTIDELAKNQYVNNGEvaiiDSTTIEI 922
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSIVIRARAEIEEDSK----GREAIIV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 923 TELPVKTWTQTYKENVLEVMlngTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLf 1002
Cdd:TIGR01063 254 TEIPYQVNKARLIEKIAELV---REKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLAL- 329
|
330 340 350
....*....|....*....|....*....|....*..
gi 842062861 1003 dhVGSLKKYESVQDILKEFFELRMK------YYVLRK 1033
Cdd:TIGR01063 330 --VKGLPKVLNLKELLEAFVEHRKDvitrrtIFELRK 364
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1473-1560 |
2.59e-08 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 52.84 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1473 SSDSDSAGPAVTK------KQAKKRKTvlssdqsDSSDSDSGNLMSRLKGKSTAGKKAKSWEDDESFQLEETEKVvvsaA 1546
Cdd:pfam08070 14 SSDSDSDAGASKKpappkgRKARKRKP-------SSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDDFSVDLDSEV----A 82
|
90
....*....|....
gi 842062861 1547 PRSRAARTTKPVTY 1560
Cdd:pfam08070 83 PRARPGRAKKPVKY 96
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| PTZ00108 |
PTZ00108 |
DNA topoisomerase 2-like protein; Provisional |
25-1440 |
0e+00 |
|
DNA topoisomerase 2-like protein; Provisional
Pssm-ID: 240271 [Multi-domain] Cd Length: 1388 Bit Score: 1659.79 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 25 KRLSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFD-EDTGMNCRDITFVPGLYKIFDEILVNAADNKQRDKT--- 100
Cdd:PTZ00108 2 KNKTVEERYQKKTQIEHILLRPDTYIGSIETQTEDMWVYDeEKNRMVYKTITYVPGLYKIFDEILVNAADNKARDKGghr 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 101 MNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVET 180
Cdd:PTZ00108 82 MTYIKVTIDEENGEISVYNDGEGIPVQIHKEHKIYVPEMIFGHLLTSSNYDDTEKRVTGGRNGFGAKLTNIFSTKFTVEC 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 181 ACRESKRCFKQTWFDNMGRAGESKIKPFDG-DDYTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAGSTKGVRVLLNGK 259
Cdd:PTZ00108 162 VDSKSGKKFKMTWTDNMSKKSEPRITSYDGkKDYTKVTFYPDYAKFGMTEFDDDMLRLLKKRVYDLAGCFGKLKVYLNGE 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 260 RLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEV 339
Cdd:PTZ00108 242 RIAIKSFKDYVDLYLPDGEEGKKPPYPFVYTSVNGRWEVVVSLSDGQFQQVSFVNSICTTKGGTHVNYILDQLISKLQEK 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 340 VKKKNKAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQ 419
Cdd:PTZ00108 322 AKKKKKKGKEIKPNQIKNHLWVFVNCLIVNPSFDSQTKETLTTKPSKFGSTCELSEKLIKYVLKSPILENIVEWAQAKLA 401
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 420 AQLNKKCSAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQ 499
Cdd:PTZ00108 402 AELNKKMKAGKKSRILGIPKLDDANDAGGKNSEECTLILTEGDSAKALALAGLSVVGRDYYGVFPLRGKLLNVRDASLKQ 481
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 500 IMENAEINNIIKILGLQYKKNYSDPeslKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHN-FLEEFITPIIK 578
Cdd:PTZ00108 482 LMNNKEIQNLFKILGLDIGKKYEDP---KGLRYGSLMIMTDQDHDGSHIKGLLINMIHHFWPSLLKNPgFLKEFITPIVK 558
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 579 ASNK-KQEISFYSIPEFTEWKEKQsSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMI 657
Cdd:PTZ00108 559 ATKKgNQVISFFTIPDFEKWKQTV-GLKGWKIKYYKGLGTSTDKEGKEYFSNIDKHRIRFVYVDDSDDDSIDLAFSKKRV 637
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 658 EERKEWLTSFMinrrqrrehnlPEEYLyGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDGLKPGQRKVVFCCFKRND 737
Cdd:PTZ00108 638 EDRKEWITNYK-----------GGTYV-DHSKKKLTYSDFVNKELILFSIADNERSIPSLVDGLKPGQRKILFACFKRNL 705
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 738 KREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLF 817
Cdd:PTZ00108 706 KNEIKVAQLSGYVSEHSAYHHGEQSLQQTIVGMAQNFVGSNNINLLYPCGQFGSRLQGGKDHAAARYIFTKLSKITRYIF 785
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 818 PVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGT 897
Cdd:PTZ00108 786 PEEDDPILDYLEDDGQSVEPFYYVPIIPMVLVNGAEGIGTGFSTSIPNYNPLDIIDNLRRRLNGEEVRPLVPWYRGFKGT 865
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 898 IDELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKEnVLEVMLNGTEkvpALITDYKEYHTDTTVRFVVKMTEERLR 977
Cdd:PTZ00108 866 IERNPKGKFISKGIYEKVPDGTVEITELPIGKWTEDYKE-FLESETLKEK---DVIVDYRDYSTANTVHFTVKLNDGVLE 941
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 978 EAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEK 1057
Cdd:PTZ00108 942 QWEEEGIEKVFKLKSTISTTNMVLFDENGKIKKYSDALDILKEFYLVRLDLYKKRKEYLLGKLERELARLSNKVRFIKHV 1021
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1058 IQGTLVIENKPKKELIRMLQQMGYDS-------DPVKAWKDAQEKEEEEDAEDDDEKEKEDTSGPDYNYLLSMPMWYLTK 1130
Cdd:PTZ00108 1022 INGELVITNAKKKDLVKELKKLGYVRfkdiikkKSEKITAEEEEGAEEDDEADDEDDEEELGAAVSYDYLLSMPIWSLTK 1101
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1131 EKKDELCKQRDAKMTELNTLKMKAPADLWKEDLAAFTEELERVEQKEKESQNamplvkgkvgkpkvvkvknetmptpQGR 1210
Cdd:PTZ00108 1102 EKVEKLNAELEKKEKELEKLKNTTPKDMWLEDLDKFEEALEEQEEVEEKEIA-------------------------KEQ 1156
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1211 RVIPRITSTMKVQAVKKERGKGSKKEAGLVMKmefddeadaAADGTGVGLAARLTKKIKKEPTKDKGSKSGKQTTltfkp 1290
Cdd:PTZ00108 1157 RLKSKTKGKASKLRKPKLKKKEKKKKKSSADK---------SKKASVVGNSKRVDSDEKRKLDDKPDNKKSNSSG----- 1222
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1291 vqkknpwSSDEGESDSDLELMSEETAPREKRERRAAVEKKYSLSSSEDEFDDFTKSS-KTKRAVIEDDESFNPEPSAAPD 1369
Cdd:PTZ00108 1223 -------SDQEDDEEQKTKPKKSSVKRLKSKKNNSSKSSEDNDEFSSDDLSKEGKPKnAPKRVSAVQYSPPPPSKRPDGE 1295
|
1370 1380 1390 1400 1410 1420 1430
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 842062861 1370 SDVDSppppvvkkAPTKVAKAKAEKPEASSKSSSHSEASQEPAPKPVKKTAEGAAKKPPAKMTSAVSKKKA 1440
Cdd:PTZ00108 1296 SNGGS--------KPSSPTKKKVKKRLEGSLAALKKKKKSEKKTARKKKSKTRVKQASASQSSRLLRRPRK 1358
|
|
| PLN03128 |
PLN03128 |
DNA topoisomerase 2; Provisional |
28-1171 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215593 [Multi-domain] Cd Length: 1135 Bit Score: 1640.20 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 28 SVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFdEDTGMNCRDITFVPGLYKIFDEILVNAADNKQRDKTMNCIKVN 107
Cdd:PLN03128 2 TIEETYQKKTQLEHILLRPDTYIGSTEKHTQTLWVY-EGGEMVNREVTYVPGLYKIFDEILVNAADNKQRDPSMDSLKVD 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 108 IDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETACRESKR 187
Cdd:PLN03128 81 IDVEQNTISVYNNGKGIPVEIHKEEGVYVPELIFGHLLTSSNFDDNEKKTTGGRNGYGAKLANIFSTEFTVETADGNRGK 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 188 CFKQTWFDNMGRAGESKIKPFDG-DDYTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAG-STKGVRVLLNGKRLPINN 265
Cdd:PLN03128 161 KYKQVFTNNMSVKSEPKITSCKAsENWTKITFKPDLAKFNMTRLDEDVVALMSKRVYDIAGcLGKKLKVELNGKKLPVKS 240
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 266 FRTYVDLYvkDKVDETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEVVKKKNK 345
Cdd:PLN03128 241 FQDYVGLY--LGPNSREDPLPRIYEKVNDRWEVCVSLSDGSFQQVSFVNSIATIKGGTHVDYVADQIVKHIQEKVKKKNK 318
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 346 AGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKFKAQAQLnKK 425
Cdd:PLN03128 319 NATHVKPFQIKNHLWVFVNCLIENPTFDSQTKETLTTRPSSFGSKCELSEEFLKKVEKCGVVENILSWAQFKQQKEL-KK 397
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 426 CSAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAE 505
Cdd:PLN03128 398 KDGAKRQRLTGIPKLDDANDAGGKKSKDCTLILTEGDSAKALAMSGLSVVGRDHYGVFPLRGKLLNVREASHKQIMKNAE 477
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 506 INNIIKILGLQYKKNYsDPESLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLR-HNFLEEFITPIIKASNKKQ 584
Cdd:PLN03128 478 ITNIKQILGLQFGKTY-DEENTKSLRYGHLMIMTDQDHDGSHIKGLIINFFHSFWPSLLKiPGFLVEFITPIVKATKGGK 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 585 EISFYSIPEFTEWKEK-QSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLAFSKKMIEERKEW 663
Cdd:PLN03128 557 SLSFYTMPEYEAWKESlEGETKGWTIKYYKGLGTSTSEEAKEYFSNLDIHKKEFLWQSDEDGDLIDMAFSKKRVEDRKIW 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 664 LTSFMinrrqrrehnlPEEYLyGQETKSLSYHDFINKELVLFSNSDNERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKV 743
Cdd:PLN03128 637 LNNYE-----------PGTFL-DQTGNGISYSDFINKELILFSQADLARSIPSMVDGLKPSQRKVLFACFKRNLKSEIKV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 744 AQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKDSASPRYIFTMLSTLARLLFPVVDDN 823
Cdd:PLN03128 705 AQLSGYVAEHSAYHHGEASLASTIIGMAQDFVGSNNINLLTPSGQFGTRLQGGKDAASARYIFTRLSPITRALFPKDDDV 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 824 LLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELA- 902
Cdd:PLN03128 785 LLNYLNEDGQSIEPEWYCPIIPMVLVNGSEGIGTGWSTFIPNYNPRDIIANIRRLLRGEELEPMHPWYRGFKGTITEVSt 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 903 --KNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKEnVLEVMLNGTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAE 980
Cdd:PLN03128 865 srSGSYTVTGIIEQIGDTTIRITELPVRKWTQDYKE-FLEALLTGTKKKEPEIKDFKENHTDTTVHFTVTLSEEKMARAL 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 981 AAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQG 1060
Cdd:PLN03128 944 AEGLEKKFKLSTTISTSNMHLFDKDGKIKKYDSPEDILEEFFHLRLDLYVKRKEVLLENLEYELKKLDNKARFILAVVKG 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1061 TLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKEEEEDAEDDDEKEKEDT-SGPDYNYLLSMPMWYLTKEKKDELCKQ 1139
Cdd:PLN03128 1024 EIVVNNRKRAELLAELEEKGFDKFPKTAKISETNVVGDRDGEASEEEEASDNeLAKSYDYLLGMPISSLTLEKVDELRAE 1103
|
1130 1140 1150
....*....|....*....|....*....|..
gi 842062861 1140 RDAKMTELNTLKMKAPADLWKEDLAAFTEELE 1171
Cdd:PLN03128 1104 RAKKETEVEELKKTTPEDLWRKDLDAFEEALD 1135
|
|
| PLN03237 |
PLN03237 |
DNA topoisomerase 2; Provisional |
4-1570 |
0e+00 |
|
DNA topoisomerase 2; Provisional
Pssm-ID: 215641 [Multi-domain] Cd Length: 1465 Bit Score: 1476.25 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 4 TEGPLKSLFENKALSKPKKDEKRLSVERIYQKKTQLEHILLRPDTYIGSVEPVTQQMWVFDEDTGMNcRDITFVPGLYKI 83
Cdd:PLN03237 3 EKLPLQESNSANVAAAPAASSGGKTIEEMYQKKSQLEHILLRPDTYIGSIEKHTQTLWVYETDKMVQ-RSVTYVPGLYKI 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 84 FDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNG 163
Cdd:PLN03237 82 FDEILVNAADNKQRDPKMDSLRVVIDVEQNLISVYNNGDGVPVEIHQEEGVYVPEMIFGHLLTSSNYDDNEKKTTGGRNG 161
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 164 YGAKLCNIFSLKFTVETACRESKRCFKQTWFDNMGRAGESKI-KPFDGDDYTCITFQPDLAKFKMQALDKDTVALLTRRA 242
Cdd:PLN03237 162 YGAKLTNIFSTEFVIETADGKRQKKYKQVFSNNMGKKSEPVItKCKKSENWTKVTFKPDLAKFNMTHLEDDVVALMKKRV 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 243 YDIAGST-KGVRVLLNGKRLPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTKG 321
Cdd:PLN03237 242 VDIAGCLgKTVKVELNGKRIPVKSFSDYVDLYLESANKSRPENLPRIYEKVNDRWEVCVSLSEGQFQQVSFVNSIATIKG 321
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 322 GRHTDYVADQIVSKLIEVVKKKNKAGvAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQA 401
Cdd:PLN03237 322 GTHVDYVTNQIANHVMEAVNKKNKNA-NIKAHNVKNHLWVFVNALIDNPAFDSQTKETLTLRQSSFGSKCELSEDFLKKV 400
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 402 NGCGIVESIMNWVKFKAQAQLnKKCSAVKHTKIKGVPKLDDANDAGGKNSNSCTLILTEGDSAKTLAVSGLGVVGRDRYG 481
Cdd:PLN03237 401 MKSGIVENLLSWADFKQSKEL-KKTDGAKTTRVTGIPKLEDANEAGGKNSEKCTLILTEGDSAKALAVAGLSVVGRNYYG 479
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 482 VFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYsdpESLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWP 561
Cdd:PLN03237 480 VFPLRGKLLNVREASHKQIMNNAEIENIKQILGLQHGKQY---ESVKSLRYGHLMIMTDQDHDGSHIKGLLINFIHSFWP 556
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 562 SLLR-HNFLEEFITPIIKASNK-KQEISFYSIPEFTEWKEK-QSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFK 638
Cdd:PLN03237 557 SLLKvPSFLVEFITPIVKATRRgKKVLSFYSMPEYEEWKESlGGNATGWSIKYYKGLGTSTAKEGKEYFKNLGKHKKDFV 636
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 639 YSGPADDEAITLAFSKKMIEERKEWLTSFMinrrqrrehnlPEEYLyGQETKSLSYHDFINKELVLFSNSDNERSIPCMV 718
Cdd:PLN03237 637 WEDEQDGDAIELAFSKKKIEARKNWLRQYE-----------PGTHL-DQTQKDVKYSDFVNKELILFSMADLQRSIPSMV 704
|
730 740 750 760 770 780 790 800
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 719 DGLKPGQRKVVFCCFKRNDKREVKVAQLAGSVAEMSAYHHGEVSLMMTIVGLAQNFVGSNNLNLLQPLGQFGTRLHGGKD 798
Cdd:PLN03237 705 DGLKPGQRKILFCSFKRNFVKEAKVAQLSGYVSEHSAYHHGEQSLASTIIGMAQDFVGSNNINLLLPNGQFGTRLQGGKD 784
|
810 820 830 840 850 860 870 880
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 799 SASPRYIFTMLSTLARLLFPVVDDNLLKYNYDDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYDVREIINNIHRM 878
Cdd:PLN03237 785 HASARYIFTRLSPITRFLFPKDDDILLDYLNEDGQSIEPTWYMPIIPTVLVNGAEGIGTGWSTFIPNYNPRDIVANIRRL 864
|
890 900 910 920 930 940 950 960
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 879 LNGEEPLPMLPSYKGFKGTIDELAKNQ----YVNNGEVAIIDSTTIEITELPVKTWTQTYKEnVLEVMLNGTEKVPA-LI 953
Cdd:PLN03237 865 LNGESMEPMHPWYRGFKGTIEKTASKEggctYTITGLYEEVDETTLRITELPIRRWTDDYKE-FLESLKTDNNKNKDpFI 943
|
970 980 990 1000 1010 1020 1030 1040
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 954 TDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVGSLKKYESVQDILKEFFELRMKYYVLRK 1033
Cdd:PLN03237 944 KDVKAYNDDTTVHFEVILSEENMLAAKQEGLLKKFKLTTTISTSNMHLFDSKGVIKKYDTPEQILEEFFHLRLEYYEKRK 1023
|
1050 1060 1070 1080 1090 1100 1110 1120
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1034 DWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYDSDPVKAWKDAQEKE-----EEEDAEDDDEKE 1108
Cdd:PLN03237 1024 EVLLKNLEFELLKLENKVRFILAVVDGEIIVNNRKKADLVEELRQKGFTPFPKKAKSVEAAVAgatddAAEEEEEIDVSS 1103
|
1130 1140 1150 1160 1170 1180 1190 1200
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1109 KEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAPADLWKEDLAAFTEELERVEQKEKESQnamplvk 1188
Cdd:PLN03237 1104 SSGVRGSDYDYLLSMAIGTLTLEKVQELCADRDKLNIEVEDLKKTTPKSLWLKDLDALEKELDKLDKEDAKAE------- 1176
|
1210 1220 1230 1240 1250 1260 1270 1280
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1189 gkvgkpkvvkvknetmptpqgrrvipritstmkvQAVKKERGKGSKKEAGLVMKMefddeadaaadgtgvglaarlTKKI 1268
Cdd:PLN03237 1177 ----------------------------------EAREKLQRAAARGESGAAKKV---------------------SRQA 1201
|
1290 1300 1310 1320 1330 1340 1350 1360
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1269 KKEPTKDKgsksgkqttltfkpVQKKNPWSSDEGESDSDLELMSEETAPREKRERRAAVEKKYSLSSSEDEFDDFTKSSK 1348
Cdd:PLN03237 1202 PKKPAPKK--------------TTKKASESETTEETYGSSAMETENVAEVVKPKGRAGAKKKAPAAAKEKEEEDEILDLK 1267
|
1370 1380 1390 1400 1410 1420 1430 1440
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1349 TKRAVIEDDESfnPEPSAAPDSDVDSPPPPVVKKAPTKVAKAKAekPEASSKSSSHSEASQEPAPKPVKKTAEG-AAKKP 1427
Cdd:PLN03237 1268 DRLAAYNLDSA--PAQSAKMEETVKAVPARRAAARKKPLASVSV--ISDSDDDDDDFAVEVSLAERLKKKGGRKpAAANK 1343
|
1450 1460 1470 1480 1490 1500 1510 1520
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1428 PAKMTSAVSKKKAADSKQPSILDVlskaspkkskvvkkpTAVKPLSSDSDSAGpavTKKQAKKRKTVLSSDQsdssdsds 1507
Cdd:PLN03237 1344 KAAKPPAAAKKRGPATVQSGQKLL---------------TEMLKPAEAIGISP---EKKVRKMRASPFNKKS-------- 1397
|
1530 1540 1550 1560 1570 1580
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 842062861 1508 gnlmSRLKGKSTAGKKAKSWEDDESFQLEETEKVVVSAAPRSRAARtTKPVTYAL-DSDSDDED 1570
Cdd:PLN03237 1398 ----GSVLGRAATNKETESSENVSGSSSSEKDEIDVSAKPRPQRAN-RKQTTYVLsDSESESAD 1456
|
|
| TOP2c |
smart00433 |
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE |
79-668 |
0e+00 |
|
TopoisomeraseII; Eukaryotic DNA topoisomerase II, GyrB, ParE
Pssm-ID: 214659 [Multi-domain] Cd Length: 594 Bit Score: 772.50 E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 79 GLYKIFDEILVNAADNKQRDKtMNCIKVNIDPENnTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVT 158
Cdd:smart00433 1 GLHHLVDEIVDNAADEALAGY-MDTIKVTIDKDN-SISVEDNGRGIPVEIHPKEKKYAPEVIFTVLHAGGKFDDDAYKVS 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 159 GGRNGYGAKLCNIFSLKFTVETACResKRCFKQTWFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMqaLDKDTVALL 238
Cdd:smart00433 79 GGLHGVGASVVNALSTEFEVEVARD--GKEYKQSFSNNGKPLSEPKIIGDTKKDGTKVTFKPDLEIFGM--TTDDDFELL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 239 TRRAYDIAGSTKGVRVLLNGKR-------LPINNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKG-FQQV 310
Cdd:smart00433 155 KRRLRELAFLNKGVKITLNDERsdeektfLFEGGIKDYVELLNKNKELLSPEPTYIEGEKDNIRVEVAFQYTDGYsENIV 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 311 SFVNSIATTKGGRHTDYVADQIVSKLIEVVKKKNKAGVA-VKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGS 389
Cdd:smart00433 235 SFVNNIATTEGGTHENGFKDALTRVINEYAKKKKKLKEKnIKGEDVREGLTAFISVKIPEPQFEGQTKEKLGTSEVRFGV 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 390 A-----CSLSDKFVKQANGCGIVESIMNWVKFKAQAQ-LNKKCSAVKHTKIKGVPKLDDANDAGGKNsnsCTLILTEGDS 463
Cdd:smart00433 315 EkivseCLLSFLEENPVEASKIVEKVLLAAKARAAAKkARELTRKKKLSSISLPGKLADASSAGPKK---CELFLVEGDS 391
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 464 AKTLAVSGLgvvGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYsdpeSLKSLRYGKLMIMTDQDQ 543
Cdd:smart00433 392 AGGSAKSGR---DRDFQAILPLRGKILNVEKASLDKILKNEEIQALITALGLGIGKDF----DIEKLRYGKIIIMTDADV 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 544 DGSHIKGLLINFIHHNWPSLLRHNFLEEFITPIIKASNKKQ--EISFYSIPEFTEWKEKQSSIK-SWKIKYYKGLGTSTS 620
Cdd:smart00433 465 DGSHIKGLLLTFFYRYMPPLIEAGFVYIAIPPLYKVTKGKKkyVYSFYSLDEYEKWLEKTEGNKsKYEIQRYKGLGEMNA 544
|
570 580 590 600
....*....|....*....|....*....|....*....|....*....
gi 842062861 621 KEAKEYFSDMTRHRIPFKYSGPADD-EAITLAFSKKMIEERKEWLTSFM 668
Cdd:smart00433 545 DQLWETTMDPERRTLLFVTLDDADEaDLIFSALMGDKVEPRKEWIEENA 593
|
|
| TOP4c |
smart00434 |
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC |
692-1161 |
2.15e-171 |
|
DNA Topoisomerase IV; Bacterial DNA topoisomerase IV, GyrA, ParC
Pssm-ID: 214660 [Multi-domain] Cd Length: 444 Bit Score: 522.51 E-value: 2.15e-171
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 692 LSYHDFINKELVLFSNS-DNERSIPCMVDGLKPGQRKVVFCCFKRNDKR-EVKVAQLAGSVAEMSAYH-HGEVSLMMTIV 768
Cdd:smart00434 1 IDIEDFINKEYLDYSMSvINGRAIPDVRDGLKPVQRRILYAMFKRGLTPdEPKVKSARGVGDVMGKYHpHGDSSLYDTIV 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 769 GLAQNFVgsNNLNLLQPLGQFGTRLhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNlRVEPEWYMPIIPL 846
Cdd:smart00434 81 RMAQDFS--NNYPLLDGQGNFGSRL-DGDDAAAMRYTETRLSPLARLLLPDIDKDTVDFvpNYDGQ-EIEPTVLPPIIPN 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 847 VLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEP----LPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEI 922
Cdd:smart00434 157 LLVNGSSGIAVGMATNIPPHNLREVIDAVRRLIDNPDAsideLMMIPWGPDFPTGGEIVGPGKYVVRGKIEIEDDNTIVI 236
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 923 TELPVKTWTQTYKENVLEVMLNGteKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLF 1002
Cdd:smart00434 237 TELPYQVNTADLIEKIAELVKDK--KIEGIIDVRDESHDRTGVRIVIELKRGAMAEVVLNGLYKLTKLQTTFSINMLALF 314
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1003 DHvGSLKKYESVQdILKEFFELRMKYYVLRKDWLVGMLGAEsAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQMGYD 1082
Cdd:smart00434 315 DN-GRPKKYNLKE-ILKEFLDHRLEVYTRRKEYLLGKLEAE-RLHILEGLFIALSIIDEIIVLIRSSKDLAKEAKEKLME 391
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 842062861 1083 SdpvkawkdaqekeeeedaedddekekEDTSGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAPADLWKE 1161
Cdd:smart00434 392 R--------------------------FELSEIQADAILDMRLRRLTKLEVEKLEKELKELEKEIEDLEKILASEEWLN 444
|
|
| TOP4c |
cd00187 |
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), ... |
710-1166 |
8.30e-154 |
|
DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes in DNA topology by catalysing the concerted breakage and rejoining of DNA strands during normal cellular growth.
Pssm-ID: 238111 [Multi-domain] Cd Length: 445 Bit Score: 475.52 E-value: 8.30e-154
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 710 NERSIPCMVDGLKPGQRKVVFCCFKRN---DKREVKVAQLAGSVAEMSaYHHGEVSLMMTIVGLAQNFvgSNNLNLLQPL 786
Cdd:cd00187 1 NGRALPDVRDGLKPVQRRILYAMFKRGltpDKPEKKVARLVGDVAGKY-HPHGDSSLYDTIVRMAQDF--SNNIPLLDPQ 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 787 GQFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNlRVEPEWYMPIIPLVLANGGEGIGTGWASRIP 864
Cdd:cd00187 78 GNFGSR--DGDDAAAMRYTETRLSPIARLLLPDIDDPTVDFvpNYDGQ-EVEPEVLPPIFPNLLVNGSSGIAVGMATNIP 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 865 NYDVREIINNIHRMLNGEEP-------LPMLPSYKGFkGTIDELA---------KNQYVNNGEVAIIDS---TTIEITEL 925
Cdd:cd00187 155 PHNLREVIDALRALIDNPEAsidelmeIIKGPDFPTG-GIIEGRAgireayetgRGRYIIRGKYEIEDDegrNTIEITEL 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 926 PVKTWTQTYKENVLEVMLNGTEkvpALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNsMVLFDHV 1005
Cdd:cd00187 234 PYQVNKAKLKEKIAELVKDKKI---EGISDVRDESDREGIRFVIELKRGAMAEVVLNGLYKVTKLQTTFGIN-MVAFDPN 309
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1006 GSLKKYeSVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILE--KIQGTLVIENKPKKELIRMLQQMGYDS 1083
Cdd:cd00187 310 GRPKKL-NLKEILQEFLDHRLEVYTRRKEYELGKAEARLHILEGLLKAILNidEVINLIRSSDEAKKALIEELEKLGFSE 388
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1084 DpvkawkdaqekeeeedaedddekekedtsgpDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLK-----MKAPADL 1158
Cdd:cd00187 389 I-------------------------------QADAILDMRLRRLTKLEREKLLKELKELEAEIEDLEkilasEERPKDL 437
|
....*...
gi 842062861 1159 WKEDLAAF 1166
Cdd:cd00187 438 WKEELDEF 445
|
|
| DNA_topoisoIV |
pfam00521 |
DNA gyrase/topoisomerase IV, subunit A; |
712-1163 |
1.22e-142 |
|
DNA gyrase/topoisomerase IV, subunit A;
Pssm-ID: 459843 [Multi-domain] Cd Length: 432 Bit Score: 445.07 E-value: 1.22e-142
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 712 RSIPCMVDGLKPGQRKVVFCCFK--RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFVGsnNLNLLQPLGQ 788
Cdd:pfam00521 1 RAIPDVRDGLKPVQRRILYAMFEllNLDKPYKKVARLVGDV--MGKYHpHGDASLYDAIVRMAQDFVG--NIPLLDGQGN 76
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 789 FGTRLHGGKDsASPRYIFTMLSTLARLLFPVVDDNLLKYNYD-DNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNYD 867
Cdd:pfam00521 77 FGSRIDGDKD-AAMRYTETRLSKIARELFPDIDDDTVDYVPNyDGTEVEPTVLPPIIPNLLVNGAEGIAVGMATNIPPHN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 868 VREIINNIHRMLNGEEP-----LPMLPSYKGFKGTIDELA--------KNQYVNNGEVAIIDSTTIEITELPVKTWTQTY 934
Cdd:pfam00521 156 LREIIDALIALLDGPEAtllmkYIMGPDFPTGGGIIGKGGikeayktgRGKITVRAKVEIEDRKTIVITELPYGVWTSDL 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 935 KENVLEvmLNGTEKVPaLITDYKEYhTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHVgslKKYESV 1014
Cdd:pfam00521 236 IEKIEE--LVKNGKIK-GISDIRDE-SDRGVRIVIELKRGADPEVVLNDLYKKTKLQTSFSTNNLVLFDGG---PKYLGL 308
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1015 QDILKEFFELRMKYYVLRKDWLVGMLGAESAKLS------NQARFILEKIQGTLViENKPKKELIRMLQQMgydsdpvka 1088
Cdd:pfam00521 309 KEILKEFLDHRLEVYERRKEYLLEKLEERLHILEgllialNNIDFVIEIIRGSID-RKKAKKNLIEELSEI--------- 378
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1089 wkdaqekeeeedaedddekekedtsgpDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKM-----KAPADLWKEDL 1163
Cdd:pfam00521 379 ---------------------------QADYLLDMRLRRLTKEEVDKLLEEIDELEKEIAELEKllaseKKLNDLWIEEL 431
|
|
| HATPase_TopII-like |
cd16930 |
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the ... |
76-221 |
5.67e-98 |
|
Histidine kinase-like ATPase domain of eukaryotic topoisomerase II; This family includes the histidine kinase-like ATPase (HATpase) domains of human topoisomerase IIA (TopIIA) and TopIIB, Saccharomyces cerevisae TOP2p, and related proteins. These proteins catalyze the passage of DNA double strands through a transient double-strand break in the presence of ATP.
Pssm-ID: 340407 [Multi-domain] Cd Length: 147 Bit Score: 310.81 E-value: 5.67e-98
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 76 FVPGLYKIFDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 155
Cdd:cd16930 1 YVPGLYKIFDEILVNAADNKQRDKSMTCIKVTIDPENNEISVWNNGKGIPVVIHKEEKIYVPEMIFGHLLTSSNYDDDEK 80
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 842062861 156 KVTGGRNGYGAKLCNIFSLKFTVETACRESKRCFKQTWFDNMGRAGESKIKPF-DGDDYTCITFQPD 221
Cdd:cd16930 81 KVTGGRNGYGAKLCNIFSTEFTVETADSESKKKFKQTWTNNMGKASEPKITPYeKGKDYTKVTFKPD 147
|
|
| TopoIIA_Trans_ScTopoIIA |
cd03481 |
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the ... |
264-416 |
4.68e-88 |
|
TopoIIA_Trans_ScTopoIIA: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topo IIA. S. cerevisiae Topo IIA is a homodimer encoded by a single gene. The type IIA enzymes are the predominant form of topoisomerase and are found in some bacteriophages, viruses and archaea, and in all bacteria and eukaryotes. All type IIA topoisomerases are related to each other at amino acid sequence level, though their oligomeric organization sometimes differs. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. TopoIIA enzymes also catenate/ decatenate duplex rings. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes.
Pssm-ID: 239563 [Multi-domain] Cd Length: 153 Bit Score: 283.02 E-value: 4.68e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 264 NNFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEVVKKK 343
Cdd:cd03481 1 KSFKDYVKLYLKDANKEDGPPPPVVYEPVNDRWEVAVALSDGQFQQVSFVNSIATTKGGTHVDYVADQIVKKLDEVVKKK 80
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 842062861 344 NKAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGCGIVESIMNWVKF 416
Cdd:cd03481 81 NKGGINVKPFQVKNHLWIFVNCLIENPSFDSQTKETLTTKPKSFGSKCELSEKFLKKAVKSGIVESVLSWAKF 153
|
|
| 39 |
PHA02569 |
DNA topoisomerase II large subunit; Provisional |
40-666 |
9.34e-86 |
|
DNA topoisomerase II large subunit; Provisional
Pssm-ID: 177398 [Multi-domain] Cd Length: 602 Bit Score: 293.58 E-value: 9.34e-86
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 40 EHILLRPDTYIGSVEPVTQQMWVFDedtgmNCRDITFVPGLYKIFDEILVNAADNKQRDKTMNCIKVNIDPENNTISVWN 119
Cdd:PHA02569 11 EHILKRPGMYIGSVAYEAHERFLFG-----KFTQVEYVPGLVKIIDEIIDNSVDEAIRTNFKFANKIDVTIKNNQVTVSD 85
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 120 NGKGIP---VVEHKVEKVYVPALIFGQLLTSSNYDDDEKkVTGGRNGYGAKLCNIFSLKFTVETACRESK---RCFkqtw 193
Cdd:PHA02569 86 NGRGIPqamVTTPEGEEIPGPVAAWTRTKAGSNFDDTNR-VTGGMNGVGSSLTNFFSVLFIGETCDGKNEvtvNCS---- 160
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 194 fDNMGRAG-ESKIKPFDGddyTCITFQPDLAKFKMQALDKDTVALLTRRAYDIAGSTKGVRVLLNGKRLPiNNFRTYVDL 272
Cdd:PHA02569 161 -NGAENISwSTKPGKGKG---TSVTFIPDFSHFEVNGLDQQYLDIILDRLQTLAVVFPDIKFTFNGKKVS-GKFKKYAKQ 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 273 YVKDkvdetgsplTVVHEmvNERWEVCLTLSEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEVVKKKNKagVAVKP 352
Cdd:PHA02569 236 FGDD---------TIVQE--NDNVSIALAPSPDGFRQLSFVNGLHTKNGGHHVDCVMDDICEELIPMIKKKHK--IEVTK 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 353 FQVKN--HMWLFVNCLIeNPSFDSQTKENMTLQQKNFGSACSLS-DKFVKQ-ANGCGIVESIMnwvkfkaQAQLNKKCSA 428
Cdd:PHA02569 303 ARVKEclTIVLFVRNMS-NPRFDSQTKERLTSPFGEIRNHIDLDyKKIAKQiLKTEAIIMPII-------EAALARKLAA 374
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 429 VKHTKIKGVPKLDDANDAGGKNSNSC------TLILTEGDSAKTLAVSglgVVGRDRYGVFPLRGKMLNVREASHKQIME 502
Cdd:PHA02569 375 EKAAETKAAKKAKKAKVAKHIKANLIgkdaetTLFLTEGDSAIGYLIE---VRDEELHGGYPLRGKVLNTWGMSYADILK 451
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 503 NAEINNIIKILGLQYKknysdpESLKSLRYGKLMIMTDQDQDG-SHIKGLLINFIhHNWPSLLRHNFLEEFITPIIKASN 581
Cdd:PHA02569 452 NKELFDICAITGLVLG------EKAENMNYKNIAIMTDADVDGkGSIYPLLLAFF-SRWPELFEQGRIRFVKTPVIIAQV 524
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 582 KKQEISFYSIPEFTEWKEkqsSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFkysGPADDEAITLAFSKKMiEERK 661
Cdd:PHA02569 525 GKETKWFYSLDEFEKAKD---SLKKWSIRYIKGLGSLRKSEYRRVINNPVYDVVVL---PDDWKELFEMLFGDDA-DLRK 597
|
....*
gi 842062861 662 EWLTS 666
Cdd:PHA02569 598 DWMSQ 602
|
|
| TOPRIM_TopoIIA |
cd03365 |
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the ... |
454-574 |
6.44e-81 |
|
TOPRIM_TopoIIA: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173785 [Multi-domain] Cd Length: 120 Bit Score: 261.08 E-value: 6.44e-81
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 454 CTLILTEGDSAKTLAVSGLGVVGRDRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKnySDPESLKSLRYG 533
Cdd:cd03365 1 CTLILTEGDSAKALAVAGLSVVGRDYYGVFPLRGKLLNVREASHKQIMENAEIQNIKKILGLQHGK--SDYESTKSLRYG 78
|
90 100 110 120
....*....|....*....|....*....|....*....|..
gi 842062861 534 KLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRH-NFLEEFIT 574
Cdd:cd03365 79 RLMIMTDQDHDGSHIKGLLINFIHSFWPSLLKIpGFLVEFIT 120
|
|
| 52 |
PHA02592 |
DNA topisomerase II medium subunit; Provisional |
690-1167 |
2.68e-74 |
|
DNA topisomerase II medium subunit; Provisional
Pssm-ID: 222896 [Multi-domain] Cd Length: 439 Bit Score: 254.98 E-value: 2.68e-74
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 690 KSLSYHDFINKELVLFSNSD-NERSIPCMVDGLKPGQRKVVFCC--FKRNDKREV-KVAQLAGSVAEMSaYHHGEVSLMM 765
Cdd:PHA02592 4 KERSLKSIVNNEALEYAMYTvEERAIPNLIDGLKPVQRFVIHRAleYAKGNKEKFdKVAAIAGGVADLG-YHHGETSAQD 82
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 766 TIVGLAQNFvgSNNLNLLQPLGQFGTRLhgGKDSASPRYIFTMLSTLARLLFPVVDdnlLKYNYDDNLRVEPEWYMPIIP 845
Cdd:PHA02592 83 AGALMANTW--NNNIPLLDGQGNFGSRL--VQKAAAARYIFARVHDNFRKIYKDED---LAPVHEDPEHIPPAFYLPIIP 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 846 LVLANGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEPLPMLPSYKGFKGTIDELAKNQYVNNGEVAIIDSTTIEITEL 925
Cdd:PHA02592 156 MVLLNGVSGIATGYATNILPHSPKSVIKAVLAALNGKDITEPKVQFPEFKGEVVEIEPGSYEIRGTYELNGKTKLHITEI 235
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 926 PVKTWTQTYKENVLEVMLNGTekvpalITDYKEYHTDtTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLfDHV 1005
Cdd:PHA02592 236 PVKYDRETYVAVLDPLEEKGK------IVSYDDCTED-GFRFKVTLKREENEEATHEKIMKDFGLIERVSQNITVI-NEN 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1006 GSLKKYESVQDILKEFFELRMKYYVLRKDWLVGMLGAESAKLSNQARFILEKIQGTLVIENKPKKELIRMLQQmgYDSDp 1085
Cdd:PHA02592 308 GKLKVYENAEDLIRDFVEIRKTYVQKRIQYEIKETEEAFDLALAKAEFIKRVIAGEIVLQGKTRSELTEELSD--NKDF- 384
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1086 vkawkdaqekeeeedaedddekekedtsGPDYNYLLSMPMWYLTKEKKDELCKQRDAKMTELNTLKMKAPADLWKEDLAA 1165
Cdd:PHA02592 385 ----------------------------GEYADKLVAMNIYSMTSDEREKLQKEAEELEKEHEYWKKTTAKKEYIKDLEE 436
|
..
gi 842062861 1166 FT 1167
Cdd:PHA02592 437 LK 438
|
|
| TOPRIM_C |
pfam16898 |
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the ... |
572-710 |
3.06e-73 |
|
C-terminal associated domain of TOPRIM; TOPRIM_C is found as the C-terminal extension of the TOPRIM domain, pfam01751 in metazoa.
Pssm-ID: 465302 [Multi-domain] Cd Length: 127 Bit Score: 239.73 E-value: 3.06e-73
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 572 FITPIIKASNKKQEISFYSIPEFTEWKEKQSSIKSWKIKYYKGLGTSTSKEAKEYFSDMTRHRIPFKYSGPADDEAITLA 651
Cdd:pfam16898 1 FITPIVKVTKGKEVISFFSLPEYEEWKESTPNLKGWKIKYYKGLGTSTSEEAKEYFSNLDKHRKEFKYLGDDDDEAIDLA 80
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*....
gi 842062861 652 FSKKMIEERKEWLTSFMinrrqrrehnlPEEYLYgQETKSLSYHDFINKELVLFSNSDN 710
Cdd:pfam16898 81 FSKKKADDRKEWLRNFN-----------PGTYLD-HSTKEISYSDFINKELILFSMADN 127
|
|
| TOPRIM_TopoIIA_like |
cd01030 |
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-574 |
2.93e-64 |
|
TOPRIM_TopoIIA_like: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to Saccharomyces cerevisiae Topoisomerase II. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173780 [Multi-domain] Cd Length: 115 Bit Score: 213.52 E-value: 2.93e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 454 CTLILTEGDSAKTLAVSGLGVVgrdRYGVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYsdpESLKSLRYG 533
Cdd:cd01030 1 CELILVEGDSAGGSAKQGRDRV---FQAVFPLRGKILNVEKASLKKILKNEEIQNIIKALGLGIGKDD---FDLDKLRYG 74
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 842062861 534 KLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLEEFIT 574
Cdd:cd01030 75 KIIIMTDADVDGSHIRTLLLTFFYRFWPSLLENGFLYIAQT 115
|
|
| PRK05559 |
PRK05559 |
DNA topoisomerase IV subunit B; Reviewed |
39-616 |
2.95e-54 |
|
DNA topoisomerase IV subunit B; Reviewed
Pssm-ID: 235501 [Multi-domain] Cd Length: 631 Bit Score: 201.87 E-value: 2.95e-54
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 39 LEHILLRPDTYIGSVepvtqqmwvfDEDtgmncrditfvpGLYKIFDEILVNAAD-------NKqrdktmncIKVNIDpE 111
Cdd:PRK05559 19 LEPVRKRPGMYIGST----------DTR------------GLHHLVQEVIDNSVDealaghgKR--------IEVTLH-A 67
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 112 NNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETAcRESKRcFKQ 191
Cdd:PRK05559 68 DGSVSVRDNGRGIPVGIHPEEGKSGVEVILTKLHAGGKFSNKAYKFSGGLHGVGVSVVNALSSRLEVEVK-RDGKV-YRQ 145
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 192 TwFDNMGRAGESKI--KPFDGDDYTCITFQPD-----LAKFKMQALDKdtvaLLTRRAYDIagstKGVRVLLNGKRLpin 264
Cdd:PRK05559 146 R-FEGGDPVGPLEVvgTAGKRKTGTRVRFWPDpkifdSPKFSPERLKE----RLRSKAFLL----PGLTITLNDERE--- 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 265 nfrTYVDLY---VKDKVDETGSPLTVVH---------EMVNERWEVCLT-LSEKGFQQVSFVNSIATTKGGRHtdyVA-- 329
Cdd:PRK05559 214 ---RQTFHYengLKDYLAELNEGKETLPeefvgsfegEAEGEAVEWALQwTDEGGENIESYVNLIPTPQGGTH---ENgf 287
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 330 -DQIVSKLIEVVKKKN--KAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQknfgsACSLSDKFVKQA----- 401
Cdd:PRK05559 288 rEGLLKAVREFAEKRNllPKGKKLEGEDVREGLAAVLSVKIPEPQFEGQTKEKLGSRE-----ARRFVSGVVKDAfdlwl 362
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 402 --NGcGIVESIMNWVKFKAQAQLNKKCSAVKHTKIKGV---PKLddaNDAGGKNSNSCTLILTEGDSAktlavSGLGVVG 476
Cdd:PRK05559 363 nqNP-ELAEKLAEKAIKAAQARLRAAKKVKRKKKTSGPalpGKL---ADCTSQDPERTELFLVEGDSA-----GGSAKQA 433
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 477 RDRY--GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYsdpeSLKSLRYGKLMIMTDQDQDGSHIKGLLIN 554
Cdd:PRK05559 434 RDREfqAILPLRGKILNTWEASLDDVLANEEIHDIIVAIGIGPGDSF----DLEDLRYGKIIIMTDADVDGAHIATLLLT 509
|
570 580 590 600 610 620
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 842062861 555 FIHHNWPSLLRHNFLeeFI--TPIIKASNKKQEISFYSIPEFTEWKEKQSSI-KSWKIKYYKGLG 616
Cdd:PRK05559 510 FFYRHFPPLVEAGHV--YIalPPLYRVDKGKKKIYALDEEEKEELLKKLGKKgGKPEIQRFKGLG 572
|
|
| GyrB |
COG0187 |
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair]; |
39-616 |
2.52e-37 |
|
DNA gyrase/topoisomerase IV, subunit B [Replication, recombination and repair];
Pssm-ID: 439957 [Multi-domain] Cd Length: 635 Bit Score: 150.56 E-value: 2.52e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 39 LEHILLRPDTYIGSVepvtqqmwvfDEDtgmncrditfvpGLYKIFDEILVNA--------ADNkqrdktmncIKVNIDp 110
Cdd:COG0187 17 LEAVRKRPGMYIGST----------DER------------GLHHLVWEIVDNSidealagyCDR---------IEVTLH- 64
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 111 ENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETAcRESKRcFK 190
Cdd:COG0187 65 ADGSVTVEDNGRGIPVDIHPKEGKSALEVVLTVLHAGGKFDGGSYKVSGGLHGVGASVVNALSERLEVEVK-RDGKI-YR 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 191 QTwFDNmGRAGES--KIKPFD--GddyTCITFQPDLAKFKMQALDKDTvalLTRRAYDIAGSTKGVRVLLNGKRlpINNF 266
Cdd:COG0187 143 QR-FER-GKPVGPleKIGKTDrtG---TTVRFKPDPEIFETTEFDYET---LAERLRELAFLNKGLTITLTDER--EEEP 212
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 267 RTYVDLY---VKDKVDETGSPLTVVHEMV--------NERWEVCLTLSEKGFQQV-SFVNSIATTKGGRH---------- 324
Cdd:COG0187 213 KEETFHYeggIKDFVEYLNEDKEPLHPEViyfegekdGIEVEVALQWNDGYSENIhSFVNNINTPEGGTHetgfrtaltr 292
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 325 --TDYvADQivSKLIevvKKKNK--------AG-VAVkpfqvknhmwlfVNCLIENPSFDSQTKEnmtlqqknfgsacSL 393
Cdd:COG0187 293 viNDY-ARK--NGLL---KEKDKnltgddvrEGlTAV------------ISVKLPEPQFEGQTKT-------------KL 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 394 SDKFVKqangcGIVES-------------------IMNWVKFKAQAQLnkkcSAVKH---TKIKGVpkLDDAN------D 445
Cdd:COG0187 342 GNSEAR-----GIVESvvseklehyleenpaeakkILEKAILAARARE----AARKArelVRRKSA--LESSGlpgklaD 410
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 446 AGGKNSNSCTLILTEGDSA----KTlavsglgvvGRDRY--GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKK 519
Cdd:COG0187 411 CSSKDPEESELFIVEGDSAggsaKQ---------GRDREfqAILPLRGKILNVEKARLDKILKNEEIRDLITALGTGIGD 481
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 520 NYsdpeSLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLeeFI--TPIIKASNKKQEISFYSIPEFTEW 597
Cdd:COG0187 482 DF----DLEKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGHV--YIaqPPLYRIKKGKKTYYAYSDAELDEL 555
|
650
....*....|....*....
gi 842062861 598 KEKQSSIKSWKIKYYKGLG 616
Cdd:COG0187 556 LKELKGKKKVEIQRYKGLG 574
|
|
| DNA_gyraseB |
pfam00204 |
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal ... |
265-425 |
2.21e-34 |
|
DNA gyrase B; This family represents the second domain of DNA gyrase B which has a ribosomal S5 domain 2-like fold. This family is structurally related to PF01119.
Pssm-ID: 425522 [Multi-domain] Cd Length: 173 Bit Score: 130.04 E-value: 2.21e-34
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 265 NFRTYVDLYVKDKVDETGSPLTVVHEMVNERWEVCLTL---SEKGFQQVSFVNSIATTKGGRHTDYVADQIVSKLIEVVK 341
Cdd:pfam00204 1 GLKDFVEELNKDKKPLHKEIIYFEGESPDNRIEVEVALqwtDSYSENILSFVNNIATPEGGTHVDGFKSALTRTINEYAK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 342 KKN---KAGVAVKPFQVKNHMWLFVNCLIENPSFDSQTKENMTLQQKNFGSACSLSDKFVKQANGC-GIVESIMNWVKFK 417
Cdd:pfam00204 81 KKGllkKKDEKITGEDIREGLTAVVSVKIPDPQFEGQTKEKLGNPEVKSAVEKIVSEKLEEFLEENpEIAKKILEKALQA 160
|
....*...
gi 842062861 418 AQAQLNKK 425
Cdd:pfam00204 161 AKARLAAR 168
|
|
| gyrB |
PRK05644 |
DNA gyrase subunit B; Validated |
39-616 |
9.47e-32 |
|
DNA gyrase subunit B; Validated
Pssm-ID: 235542 [Multi-domain] Cd Length: 638 Bit Score: 133.30 E-value: 9.47e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 39 LEHILLRPDTYIGSvepvtqqmwvfdedTGMNcrditfvpGLYKIFDEILVNAADnkqrdKTM----NCIKVNIDPeNNT 114
Cdd:PRK05644 19 LEAVRKRPGMYIGS--------------TGER--------GLHHLVYEIVDNSID-----EALagycDHIEVTINE-DGS 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 115 ISVWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSLKFTVETaCRESKRcFKQT 192
Cdd:PRK05644 71 ITVTDNGRGIPVDIHPKTGK--PAVevVLTVLHAGGKFGGGGYKVSGGLHGVGVSVVNALSTWLEVEV-KRDGKI-YYQE 146
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 193 wFDN------MGRAGESKIKpfdGddyTCITFQPDLAKFKMQALDKDTvalLTRRAYDIAGSTKGVRVLLNGKRLPINNF 266
Cdd:PRK05644 147 -YERgvpvtpLEVIGETDET---G---TTVTFKPDPEIFETTEFDYDT---LATRLRELAFLNKGLKITLTDEREGEEKE 216
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 267 RTYvdLY---VKDKVDETGSPLTVVHE----MVNERW----EVCLTLSEkGFQQ--VSFVNSIATTKGGRH--------- 324
Cdd:PRK05644 217 ETF--HYeggIKEYVEYLNRNKEPLHEepiyFEGEKDgievEVAMQYND-GYSEniLSFANNINTHEGGTHeegfktalt 293
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 325 ---TDYVADqivSKLIevvKKKNK------------AGVAVKpfqvknhmwlfvnclIENPSFDSQTKEnmtlqqKnfgs 389
Cdd:PRK05644 294 rviNDYARK---NKLL---KEKDDnltgedvregltAVISVK---------------HPEPQFEGQTKT------K---- 342
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 390 acsLSDKFVKqangcGIVESIMN-----WVKFK---AQAQLNKKCSAVKH----------TKIKGV------P-KLDDAN 444
Cdd:PRK05644 343 ---LGNSEVR-----GIVDSVVSealseFLEENpnvAKKIVEKAILAARAreaarkarelTRRKSAlessslPgKLADCS 414
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 445 DaggKNSNSCTLILTEGDSAKTLAVSGlgvvgRDRY--GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYS 522
Cdd:PRK05644 415 S---KDPEESELYIVEGDSAGGSAKQG-----RDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGDDFD 486
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 523 dpesLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLeeFIT--PIIKASNKKQEIsFYSIPEFTEWKEK 600
Cdd:PRK05644 487 ----ISKLRYHKIIIMTDADVDGAHIRTLLLTFFYRYMRPLIEAGYV--YIAqpPLYKIKKGGKEY-AYSDEELDEILAE 559
|
650
....*....|....*...
gi 842062861 601 --QSSIKSWKIKYYKGLG 616
Cdd:PRK05644 560 lkLKGNPKYGIQRYKGLG 577
|
|
| TOPRIM_TopoIIA_GyrB |
cd03366 |
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain ... |
454-564 |
7.36e-24 |
|
TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the duplex DNA to remove (relax) both positive and negative supercoils in DNA. These enzymes covalently attach to the 5' ends of the cut DNA, separate the free ends of the cleaved strands, pass another region of the duplex through this gap, then rejoin the ends. These proteins also catenate/ decatenate duplex rings. DNA gyrase is more effective at relaxing supercoils than decatentating DNA. DNA gyrase in addition inserts negative supercoils in the presence of ATP. The TOPRIM domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). The conserved glutamate may act as a general base in strand joining and as a general acid in strand cleavage by topisomerases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173786 [Multi-domain] Cd Length: 114 Bit Score: 97.73 E-value: 7.36e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 454 CTLILTEGDSAktlavSGLGVVGRDRY--GVFPLRGKMLNVREASHKQIMENAEINNIIKILGLQYKKNYSdpesLKSLR 531
Cdd:cd03366 1 SELYIVEGDSA-----GGSAKQGRDRRfqAILPLRGKILNVEKARLDKILKNEEIRALITALGTGIGEDFD----LEKLR 71
|
90 100 110
....*....|....*....|....*....|...
gi 842062861 532 YGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLL 564
Cdd:cd03366 72 YHKIIIMTDADVDGAHIRTLLLTFFFRYMRPLI 104
|
|
| PRK09631 |
PRK09631 |
DNA topoisomerase IV subunit A; Provisional |
711-1072 |
7.50e-21 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 236598 [Multi-domain] Cd Length: 635 Bit Score: 99.01 E-value: 7.50e-21
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 711 ERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKVAQLAGsvaEMSAYH-HGEVSLMMTIVGLAqnfvgsNNLNLLQPLGQF 789
Cdd:PRK09631 22 DRAIPDVIDGLKPVQRRILHSLFEMHDGKFHKVANVVG---NTMKYHpHGDASIYEALVNLA------NKDLFIDKQGNF 92
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 790 GTRLHGgkDSAS-PRYIFTMLSTLAR--LLFPVVDDNLLKYnydDNLRVEPEWYMPIIPLVLANGGEGIGTGWASRIPNY 866
Cdd:PRK09631 93 GNLFTG--DPASaARYIECRLTPLAKevLYNKEITEYEPSY---DGRNNEPLCLPAKIPVILIQGAEGIAVGMATKILPH 167
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 867 DVREIINNIHRMLNGeEPLPMLPS-YKGfkGTIDelaKNQYVN-NGEVAI------IDSTTIEITELPVKTWTQTYKENV 938
Cdd:PRK09631 168 NFNEILQAVKSELLG-ESFALYPDfPTG--GIVD---VSEYADgNGKVLVrakietKDEKTIVIREIPFGTTTESLIASI 241
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 939 LEVMLNGTEKVPAlITDYkeyhTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLFDHvgsLKKYESVQDIL 1018
Cdd:PRK09631 242 EKAARKGKIKISS-INDY----TAENVEIEIKLPRGVYASEVIEALYAYTDCEVSISVNLLVIKDR---YPVIYTVTDII 313
|
330 340 350 360 370
....*....|....*....|....*....|....*....|....*....|....*...
gi 842062861 1019 KEFFELRMKYyvLRKDwlvgmLGAESAKLsnqarfiLEKIQG-TL---VIENKPKKEL 1072
Cdd:PRK09631 314 KFHAEHLQKV--LKME-----LELERAKL-------LEKIFAkTLeqiFIEERIYKRI 357
|
|
| gyrB |
PRK14939 |
DNA gyrase subunit B; Provisional |
39-586 |
2.52e-19 |
|
DNA gyrase subunit B; Provisional
Pssm-ID: 237860 [Multi-domain] Cd Length: 756 Bit Score: 94.39 E-value: 2.52e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 39 LEHILLRPDTYIGsvepvtqqmwvfDEDTGMncrditfvpGLYKIFDEILVNAAD-------NKqrdktmncIKVNIDPE 111
Cdd:PRK14939 18 LDAVRKRPGMYIG------------DTDDGT---------GLHHMVYEVVDNAIDealaghcDD--------ITVTIHAD 68
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 112 NnTISVWNNGKGIPVVEHKVEKVyvPAL--IFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFS--LKFTVEtacRESKR 187
Cdd:PRK14939 69 G-SVSVSDNGRGIPTDIHPEEGV--SAAevIMTVLHAGGKFDQNSYKVSGGLHGVGVSVVNALSewLELTIR---RDGKI 142
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 188 cFKQTWfdNMGRA-------GESKIKpfdGddyTCITFQPDLAKFKMQALDKDTVAlltRRAYDIAGSTKGVRVLLNGKR 260
Cdd:PRK14939 143 -HEQEF--EHGVPvaplkvvGETDKT---G---TEVRFWPSPEIFENTEFDYDILA---KRLRELAFLNSGVRIRLKDER 210
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 261 LPINNFRTY---VDLYVKDkVDETGSPLT-VVHEMVNERW----EVCL----TLSEKGFqqvSFVNSIATTKGGRH---- 324
Cdd:PRK14939 211 DGKEEEFHYeggIKAFVEY-LNRNKTPLHpNIFYFSGEKDgigvEVALqwndSYQENVL---CFTNNIPQRDGGTHlagf 286
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 325 --------TDYVADQIVSKlievvKKKNK-----------AGVAVKpfqvknhmwlfvnclIENPSFDSQTKENMtlqqk 385
Cdd:PRK14939 287 raaltrtiNNYIEKEGLAK-----KAKVSltgddaregltAVLSVK---------------VPDPKFSSQTKDKL----- 341
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 386 nfGSacslSDkfVKqangcGIVESIMN--WVKF------KAQAQLNKKCSAVKH----------TKIKGVpkLDDAN--- 444
Cdd:PRK14939 342 --VS----SE--VR-----PAVESLVNekLSEFleenpnEAKIIVGKIIDAARAreaarkarelTRRKGA--LDIAGlpg 406
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 445 ---DAGGKNSNSCTLILTEGDSA----KTlavsglgvvGRDRygVF----PLRGKMLNVREASHKQIMENAEINNIIKIL 513
Cdd:PRK14939 407 klaDCQEKDPALSELYLVEGDSAggsaKQ---------GRDR--KFqailPLKGKILNVEKARFDKMLSSQEIGTLITAL 475
|
570 580 590 600 610 620 630
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 842062861 514 GLQYKKNYSDPEslKsLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRHNFLeeFI--TPIIKASNKKQEI 586
Cdd:PRK14939 476 GCGIGRDEFNPD--K-LRYHKIIIMTDADVDGSHIRTLLLTFFYRQMPELIERGHL--YIaqPPLYKVKKGKQEQ 545
|
|
| gyrA |
TIGR01063 |
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). ... |
712-1033 |
1.93e-16 |
|
DNA gyrase, A subunit; This model describes the common type II DNA topoisomerase (DNA gyrase). Two apparently independently arising families, one in the Proteobacteria and one in Gram-positive lineages, are both designated toposisomerase IV. [DNA metabolism, DNA replication, recombination, and repair]
Pssm-ID: 273423 [Multi-domain] Cd Length: 800 Bit Score: 85.44 E-value: 1.93e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 712 RSIPCMVDGLKPGQRKVVFCCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgSNNLNLLQPLG 787
Cdd:TIGR01063 25 RALPDVRDGLKPVHRRILYAMYElglTPDKPYKKSARIVGDV--MGKYHpHGDSAIYDTLVRMAQDF--SLRYPLVDGQG 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 788 QFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNLRvEPEWYMPIIPLVLANGGEGIGTGWASRIPN 865
Cdd:TIGR01063 101 NFGSI--DGDPPAAMRYTEARLTKIAEELLRDIDKETVDFvpNYDGSEQ-EPTVLPSRFPNLLVNGSSGIAVGMATNIPP 177
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 866 YDVREIINNIHRMLNGEE----------PLPMLP-------------SYKGFKGTIDELAKNQYVNNGEvaiiDSTTIEI 922
Cdd:TIGR01063 178 HNLGEIIDALLAYIDNPDisiqelleviKGPDFPtggiilgrsgirsAYETGRGSIVIRARAEIEEDSK----GREAIIV 253
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 923 TELPVKTWTQTYKENVLEVMlngTEKVPALITDYKEYHTDTTVRFVVKMTEERLREAEAAGLHKVFKLQNLLTCNSMVLf 1002
Cdd:TIGR01063 254 TEIPYQVNKARLIEKIAELV---REKKIEGISDIRDESDREGIRIVIELKRDAVAEVVLNNLYKQTQLQVSFGINMLAL- 329
|
330 340 350
....*....|....*....|....*....|....*..
gi 842062861 1003 dhVGSLKKYESVQDILKEFFELRMK------YYVLRK 1033
Cdd:TIGR01063 330 --VKGLPKVLNLKELLEAFVEHRKDvitrrtIFELRK 364
|
|
| PRK09630 |
PRK09630 |
DNA topoisomerase IV subunit A; Provisional |
711-962 |
2.14e-16 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 170022 Cd Length: 479 Bit Score: 84.18 E-value: 2.14e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 711 ERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKVAQLAGSVaeMSAYHHGEVSLMMTIVGLAqnfvgsNNLNLLQPLGQFG 790
Cdd:PRK09630 22 ERAIPHILDGLKPVQRRLLWTLFRMDDGKMHKVANIAGRT--MALHPHGDAPIVEALVVLA------NKGYLIDTQGNFG 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 791 TRLHGGKDSASpRYIFTMLSTLAR-LLFpvvDDNLLKY--NYDDNLRvEPEWYMPIIPLVLANGGEGIGTGWASRIPNYD 867
Cdd:PRK09630 94 NPLTGDPHAAA-RYIEARLSPLAKeVLF---NTDLMTFhdSYDGREK-EPDILPAKLPLLLLHGVDGIAVGMTTKIFPHN 168
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 868 VREIINNIHRMLNgEEPLPMLPS-YKGfkGTID----ELAKNQYVNNGEVAIIDSTTIEITELPVKTWTQTYKENVLEVM 942
Cdd:PRK09630 169 FCELLEAQIAILN-DQPFTLLPDfPSG--GTMDaseyQDGLGSITLRASIDIINDKTLLIKEICPSTTTETLIRSIENAA 245
|
250 260
....*....|....*....|
gi 842062861 943 LNGTEKVPALitdyKEYHTD 962
Cdd:PRK09630 246 KRGIIKIDSI----QDFSTD 261
|
|
| PTZ00109 |
PTZ00109 |
DNA gyrase subunit b; Provisional |
267-566 |
1.01e-14 |
|
DNA gyrase subunit b; Provisional
Pssm-ID: 240272 [Multi-domain] Cd Length: 903 Bit Score: 79.93 E-value: 1.01e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 267 RTYVDLYVKDKV----DETGSPLTVVHEMVNERWEVCLTLSEKGFQQVSFVNSIATTkGGRHTDYVADQIvSKLIEVVKK 342
Cdd:PTZ00109 378 REFLEELIKDKTplykDINIISIRGVIKNVNVEVSLSWSLESYTALIKSFANNVSTT-AGTHIDGFKYAI-TRCVNGNIK 455
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 343 KNKA-GVAVKPFQ---VKNHMWLFVNCLIENPSFDSQTKENmtlqqknfgsacsLSDKFVKQangcgIVESIMNWvKFKA 418
Cdd:PTZ00109 456 KNGYfKGNFVNIPgefIREGMTAIISVKLNGAEFDGQTKTK-------------LGNHLLKT-----ILESIVFE-QLSE 516
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 419 QAQLNKKCSAVKHTKIKGVPKLDDANDAG-----GKNSN-----------SCT--------LILTEGDSAktlAVSGLGV 474
Cdd:PTZ00109 517 ILEFEPNLLLAIYNKSLAAKKAFEEAKAAkdlirQKNNQyystilpgklvDCIsddierneLFIVEGESA---AGNAKQA 593
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 475 VGRDRYGVFPLRGKMLNVRE-ASHKQIMENAEINNIIKILGL----QYKKNY------------------------SDPE 525
Cdd:PTZ00109 594 RNREFQAVLPLKGKILNIEKiKNNKKVFENSEIKLLITSIGLsvnpVTWRQYdlshgtkaskdesvqnnnstltkkKNSL 673
|
330 340 350 360
....*....|....*....|....*....|....*....|.
gi 842062861 526 SLKSLRYGKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLRH 566
Cdd:PTZ00109 674 FDTPLRYGKIILLTDADVDGEHLRILLLTLLYRFCPSLYEH 714
|
|
| PRK12758 |
PRK12758 |
DNA gyrase/topoisomerase IV subunit A; |
711-939 |
2.20e-13 |
|
DNA gyrase/topoisomerase IV subunit A;
Pssm-ID: 237192 [Multi-domain] Cd Length: 869 Bit Score: 75.43 E-value: 2.20e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 711 ERSIPCMVDGLKPGQRKVVFCCFKRNDKREVKVAQLAGSVaeMsAYH-HGEVSLMMTIVGLAQnfvgsNNLnLLQPLGQF 789
Cdd:PRK12758 41 ERAVPHIEDGLKPVQRRILHSMKEMDDGRYNKVANVVGHT--M-QYHpHGDASIGDALVQLGQ-----KDL-LIDTQGNW 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 790 GTRLhGGKDSASPRYIFTMLSTLA-RLLF-PVVDDNLLKYnydDNLRVEPEwYMPI-IPLVLANGGEGIGTGWASRIPNY 866
Cdd:PRK12758 112 GNIL-TGDGAAAPRYIEARLSKFAlEVVFnPKTTEWQLSY---DGRKKEPV-TLPVkFPLLLAQGAEGIAVGLSTKILPH 186
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 867 DVREIINNIHRMLNGEEP--LPMLPSykgfKGTIDELAKNQYVNNGEVAI------IDSTTIEITELPVKTWTQTYKENV 938
Cdd:PRK12758 187 NFNELIDASIAYLKGKEFklYPDFPT----GGIIDVSNYNDGERGGRVRVrakiekLDKKTLVITEIPYGTTTSSLIDSI 262
|
.
gi 842062861 939 L 939
Cdd:PRK12758 263 L 263
|
|
| TopoII_MutL_Trans |
cd00329 |
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the ... |
266-378 |
1.53e-12 |
|
MutL_Trans: transducer domain, having a ribosomal S5 domain 2-like fold, conserved in the C-terminal domain of type II DNA topoisomerases (Topo II) and DNA mismatch repair (MutL/MLH1/PMS2) proteins. This transducer domain is homologous to the second domain of the DNA gyrase B subunit, which is known to be important in nucleotide hydrolysis and the transduction of structural signals from ATP-binding site to the DNA breakage/reunion regions of the enzymes. The GyrB dimerizes in response to ATP binding, and is homologous to the N-terminal half of eukaryotic Topo II and the ATPase fragment of MutL. Type II DNA topoisomerases catalyze the ATP-dependent transport of one DNA duplex through another, in the process generating transient double strand breaks via covalent attachments to both DNA strands at the 5' positions. Included in this group are proteins similar to human MLH1 and PMS2. MLH1 forms a heterodimer with PMS2 which functions in meiosis and in DNA mismatch repair (MMR). Cells lacking either hMLH1 or hPMS2 have a strong mutator phenotype and display microsatellite instability (MSI). Mutation in hMLH1 accounts for a large fraction of Lynch syndrome (HNPCC) families.
Pssm-ID: 238202 [Multi-domain] Cd Length: 107 Bit Score: 65.36 E-value: 1.53e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 266 FRTYVDLYVKDKVDEtgSPLTVVHEMVNERWEVCLTLSE----KGFQQVSFVNSIATTKGGRHTDYVADQIVSKLievvk 341
Cdd:cd00329 1 LKDRLAEILGDKVAD--KLIYVEGESDGFRVEGAISYPDsgrsSKDRQFSFVNGRPVREGGTHVKAVREAYTRAL----- 73
|
90 100 110 120
....*....|....*....|....*....|....*....|
gi 842062861 342 kknkagvavKPFQVKNHMWLFVNCLIEN--PSFD-SQTKE 378
Cdd:cd00329 74 ---------NGDDVRRYPVAVLSLKIPPslVDVNvHPTKE 104
|
|
| HATPase_GyrB-like |
cd16928 |
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes ... |
80-262 |
4.73e-12 |
|
Histidine kinase-like ATPase domain of the B subunit of DNA gyrase; This family includes histidine kinase-like ATPase domain of the B subunit of DNA gyrase. Bacterial DNA gyrase is a type II topoisomerase (type II as it transiently cleaves both strands of DNA) which catalyzes the introduction of negative supercoils into DNA, possibly by a mechanism in which one segment of the double-stranded DNA substrate is passed through a transient break in a second segment. It consists of GyrA and GyrB subunits in an A2B2 stoichiometry; GyrA subunits catalyze strand-breakage and reunion reactions, and GyrB subunits hydrolyze ATP. DNA gyrase is found in bacteria, plants and archaea, but as it is absent in humans it is a possible drug target for the treatment of bacterial and parasite infections.
Pssm-ID: 340405 [Multi-domain] Cd Length: 180 Bit Score: 66.02 E-value: 4.73e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 80 LYKIFDEILVNAADnkqrdKTM----NCIKVNIDpENNTISVWNNGKGIPVVEHKVEKVYVPALIFGQLLTSSNYDDDEK 155
Cdd:cd16928 1 LHHLVWEIVDNSID-----EALagyaTEIEVTLH-EDNSITVEDNGRGIPVDIHPKTGKSAVEVVLTVLHAGGKFDGGSY 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 156 KVTGGRNGYGAKLCNIFSLKFTVETAcRESKRcFKQTwFDNMGRAGESKIKPFDGDDYTCITFQPDLAKFKMQALDKDTV 235
Cdd:cd16928 75 KVSGGLHGVGVSVVNALSERLEVEVK-RDGKI-YRQE-FSRGGPLTPLEVIGETKKTGTTVRFWPDPEIFEKTEFDFDTL 151
|
170 180
....*....|....*....|....*..
gi 842062861 236 AlltRRAYDIAGSTKGVRVLLNGKRLP 262
Cdd:cd16928 152 K---RRLRELAFLNKGLKIVLEDERTG 175
|
|
| PRK05561 |
PRK05561 |
DNA topoisomerase 4 subunit A; |
711-873 |
1.94e-09 |
|
DNA topoisomerase 4 subunit A;
Pssm-ID: 235503 [Multi-domain] Cd Length: 742 Bit Score: 62.43 E-value: 1.94e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 711 ERSIPCMVDGLKPGQRKVVFCCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgSNNLNLLQPL 786
Cdd:PRK05561 33 DRALPDVRDGLKPVQRRILYAMSElglTPDAKFKKSARVVGDV--LGKYHpHGDSSIYDAMVRMAQDF--SYRYPLVDGQ 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 787 GQFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNLRvEPEWyMP-IIPLVLANGGEGIGTGWASRI 863
Cdd:PRK05561 109 GNFGSI--DGDPAAAMRYTEARLSPIAELLLEEIDEGTVDFvpNFDGTLK-EPTV-LPaRFPNLLLNGATGIAVGMATDI 184
|
170
....*....|
gi 842062861 864 PNYDVREIIN 873
Cdd:PRK05561 185 PPHNLREVID 194
|
|
| PRK13979 |
PRK13979 |
DNA topoisomerase IV subunit A; Provisional |
711-873 |
1.31e-08 |
|
DNA topoisomerase IV subunit A; Provisional
Pssm-ID: 237576 [Multi-domain] Cd Length: 957 Bit Score: 59.73 E-value: 1.31e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 711 ERSIPCMVDGLKPGQRKVVFCCFKRN---DKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgSNNLNLLQPL 786
Cdd:PRK13979 36 DRALPDVRDGLKPVHRRILYGAYMLKafpDKPYYKSARIVGDI--LGKYHpHGDSSVYDAMVILAQDF--TTRMPLIDGH 111
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 787 GQFGTRlhGGKDSASPRYIFTMLSTLARLLFPVVDDNLLKY--NYDDNlRVEPEWYMPIIPLVLANGGEGIGTGWASRIP 864
Cdd:PRK13979 112 GNWGSI--DGDSAAAMRYTEARLTPIAMEMLRDIDKDVVNMvdNYSDS-EKEPEVLPARYPNLLVNGAFGIAVGLATNIP 188
|
....*....
gi 842062861 865 NYDVREIIN 873
Cdd:PRK13979 189 PHNLKEVID 197
|
|
| DTHCT |
pfam08070 |
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / ... |
1473-1560 |
2.59e-08 |
|
DTHCT (NUC029) region; The DTCHT region is the C-terminal part of DNA gyrases B / topoisomerase IV / HATPase proteins. This region is composed of quite low complexity sequence.
Pssm-ID: 462355 [Multi-domain] Cd Length: 97 Bit Score: 52.84 E-value: 2.59e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1473 SSDSDSAGPAVTK------KQAKKRKTvlssdqsDSSDSDSGNLMSRLKGKSTAGKKAKSWEDDESFQLEETEKVvvsaA 1546
Cdd:pfam08070 14 SSDSDSDAGASKKpappkgRKARKRKP-------SSSSDDSDSDFGKKPSKAVAKKKSKKVSDDDDFSVDLDSEV----A 82
|
90
....*....|....
gi 842062861 1547 PRSRAARTTKPVTY 1560
Cdd:pfam08070 83 PRARPGRAKKPVKY 96
|
|
| PRK05560 |
PRK05560 |
DNA gyrase subunit A; Validated |
712-901 |
7.43e-08 |
|
DNA gyrase subunit A; Validated
Pssm-ID: 235502 [Multi-domain] Cd Length: 805 Bit Score: 57.35 E-value: 7.43e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 712 RSIPCMVDGLKPGQRKVVFCCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgsnnlNLLQPL- 786
Cdd:PRK05560 29 RALPDVRDGLKPVHRRILYAMNElgnTPDKPYKKSARIVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLv 100
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 787 -GQ--FGTRlhGGkDS-ASPRYiftmlsTLARlLFPV------------VDdnlLKYNYDDNLRvEPEwYMPI-IPLVLA 849
Cdd:PRK05560 101 dGQgnFGSI--DG-DPaAAMRY------TEAR-MSKIahelladidketVD---FVPNYDGSEQ-EPT-VLPArFPNLLV 165
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|..
gi 842062861 850 NGGEGIGTGWASRIPNYDVREIINNIHRMLNGEEplpmlpsykgfkGTIDEL 901
Cdd:PRK05560 166 NGSSGIAVGMATNIPPHNLGEVIDACLALIDNPD------------ITIEEL 205
|
|
| Toprim |
pfam01751 |
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim ... |
455-555 |
7.21e-07 |
|
Toprim domain; This is a conserved region from DNA primase. This corresponds to the Toprim domain common to DnaG primases, topoisomerases, OLD family nucleases and RecR proteins. Both DnaG motifs IV and V are present in the alignment, the DxD (V) motif may be involved in Mg2+ binding and mutations to the conserved glutamate (IV) completely abolish DnaG type primase activity. DNA primase EC:2.7.7.6 is a nucleotidyltransferase it synthesizes the oligoribonucleotide primers required for DNA replication on the lagging strand of the replication fork; it can also prime the leading stand and has been implicated in cell division. This family also includes the atypical archaeal A subunit from type II DNA topoisomerases. Type II DNA topoisomerases catalyze the relaxation of DNA supercoiling by causing transient double strand breaks.
Pssm-ID: 396354 [Multi-domain] Cd Length: 93 Bit Score: 48.89 E-value: 7.21e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 455 TLILTEGDS-AKTLAvsglGVVGRDRYGVFPLRGKMLNVREASHKQIMenaeinNIIKILglqykknysdpeslkSLRYG 533
Cdd:pfam01751 1 ELIIVEGPSdAIALE----KALGGGFQAVVAVLGHLLSLEKGPKKKAL------KALKEL---------------ALKAK 55
|
90 100
....*....|....*....|..
gi 842062861 534 KLMIMTDQDQDGSHIKGLLINF 555
Cdd:pfam01751 56 EVILATDPDREGEAIALKLLEL 77
|
|
| GyrA |
COG0188 |
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair]; |
719-873 |
7.73e-07 |
|
DNA gyrase/topoisomerase IV, subunit A [Replication, recombination and repair];
Pssm-ID: 439958 [Multi-domain] Cd Length: 804 Bit Score: 53.89 E-value: 7.73e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 719 DGLKPGQRKVVFCCFK---RNDKREVKVAQLAGSVaeMSAYH-HGEVSLMMTIVGLAQNFvgsnnlNLLQPL--GQ--FG 790
Cdd:COG0188 41 DGLKPVHRRILYAMHElglTPDKPYKKSARVVGDV--MGKYHpHGDSAVYDALVRMAQDF------SMRYPLvdGQgnFG 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 791 TRlhGGkDS-ASPRYIFTMLSTLARLL----------FpvVDdnllkyNYDDNLRvEPEwYMP-IIPLVLANGGEGIGTG 858
Cdd:COG0188 113 SI--DG-DPaAAMRYTEARLAKIAEELladidkdtvdF--VP------NYDGSEQ-EPT-VLPaRFPNLLVNGSSGIAVG 179
|
170
....*....|....*
gi 842062861 859 WASRIPNYDVREIIN 873
Cdd:COG0188 180 MATNIPPHNLGEVID 194
|
|
| HATPase_c |
pfam02518 |
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the ... |
79-170 |
3.05e-06 |
|
Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase; This family represents the structurally related ATPase domains of histidine kinase, DNA gyrase B and HSP90.
Pssm-ID: 460579 [Multi-domain] Cd Length: 109 Bit Score: 47.36 E-value: 3.05e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 79 GLYKIFDEILVNAADNKQRDKTmncIKVNIDPENN-TISVWNNGKGIPVVEHKvekvyvpaLIFGQLLTSSnydddekKV 157
Cdd:pfam02518 5 RLRQVLSNLLDNALKHAAKAGE---ITVTLSEGGElTLTVEDNGIGIPPEDLP--------RIFEPFSTAD-------KR 66
|
90
....*....|...
gi 842062861 158 TGGRNGYGAKLCN 170
Cdd:pfam02518 67 GGGGTGLGLSIVR 79
|
|
| HATPase_c |
smart00387 |
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases. |
79-179 |
4.09e-06 |
|
Histidine kinase-like ATPases; Histidine kinase-, DNA gyrase B-, phytochrome-like ATPases.
Pssm-ID: 214643 [Multi-domain] Cd Length: 111 Bit Score: 47.26 E-value: 4.09e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 79 GLYKIFDEILVNAADNKQRDKTmncIKVNIDPENN--TISVWNNGKGIPvvEHKVEKVYVPaliFGQLltssnyddDEKK 156
Cdd:smart00387 5 RLRQVLSNLLDNAIKYTPEGGR---ITVTLERDGDhvEITVEDNGPGIP--PEDLEKIFEP---FFRT--------DKRS 68
|
90 100
....*....|....*....|...
gi 842062861 157 VTGGRNGYGAKLCNIFSLKFTVE 179
Cdd:smart00387 69 RKIGGTGLGLSIVKKLVELHGGE 91
|
|
| PLN02967 |
PLN02967 |
kinase |
1259-1373 |
2.90e-04 |
|
kinase
Pssm-ID: 215521 [Multi-domain] Cd Length: 581 Bit Score: 45.42 E-value: 2.90e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1259 GLAARLTKKIKKEPTKDKGS-----KSGKQTTLTFKPVQKKNPWSSDEGESDSDLELMSEETAPREKRERRAAVEKKYSL 1333
Cdd:PLN02967 43 LLAAGSRKKIESALAVDEEPdengaVSKKKPTRSVKRATKKTVVEISEPLEEGSELVVNEDAALDKESKKTPRRTRRKAA 122
|
90 100 110 120
....*....|....*....|....*....|....*....|.
gi 842062861 1334 SSSEDEFDDFT-KSSKTKRAVIEDDESFNPEPSAAPDSDVD 1373
Cdd:PLN02967 123 AASSDVEEEKTeKKVRKRRKVKKMDEDVEDQGSESEVSDVE 163
|
|
| TOPRIM |
cd00188 |
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type ... |
454-565 |
1.14e-03 |
|
Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from bacterial and archaea, and bacterial DNA repair proteins of the RecR/M family. This domain has two conserved motifs, one of which centers at a conserved glutamate and the other one at two conserved aspartates (DxD). This glutamate and two aspartates, cluster together to form a highly acid surface patch. The conserved glutamate may act as a general base in nucleotide polymerization by primases and in strand joining in topoisomerases and, as a general acid in strand cleavage by topisomerases and nucleases. The DXD motif may co-ordinate Mg2+, a cofactor required for full catalytic function.
Pssm-ID: 173773 [Multi-domain] Cd Length: 83 Bit Score: 39.33 E-value: 1.14e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 454 CTLILTEGDS-AKTLAVSGlgvvgRDRYGVFPLRGKMLNvreashkqimenAEINNIIKILGlqykknysdpeslkslRY 532
Cdd:cd00188 1 KKLIIVEGPSdALALAQAG-----GYGGAVVALGGHALN------------KTRELLKRLLG----------------EA 47
|
90 100 110
....*....|....*....|....*....|...
gi 842062861 533 GKLMIMTDQDQDGSHIKGLLINFIHHNWPSLLR 565
Cdd:cd00188 48 KEVIIATDADREGEAIALRLLELLKSLGKKVRR 80
|
|
| valS |
PRK14900 |
valyl-tRNA synthetase; Provisional |
1319-1447 |
7.26e-03 |
|
valyl-tRNA synthetase; Provisional
Pssm-ID: 237855 [Multi-domain] Cd Length: 1052 Bit Score: 41.13 E-value: 7.26e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 842062861 1319 EKRERRAAVEKKYS-LSSSEDEfddftkssKTKRAVIEDDESFNPE-----PSAAPDSDVD-SPPPPVVKKAPTKVAKAK 1391
Cdd:PRK14900 888 ELREKRGKLEAHRAmLSGSEAN--------SARRDTMEIQNEQKPTqdgpaAEAQPAQENTvVESAEKAVAAVSEAAQQA 959
|
90 100 110 120 130 140
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 842062861 1392 AekPEASSKSSSHSEASQEPAPKPVKKT-------AEGAAKKPPAKMTSA--VSKKKAADSKQPS 1447
Cdd:PRK14900 960 A--TAVASGIEKVAEAVRKTVRRSVKKAaatraamKKKVAKKAPAKKAAAkkAAAKKAAAKKKVA 1022
|
|
| |
