NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|808355496|ref|NP_001293570|]
View 

Phosphodiesterase [Caenorhabditis elegans]

Protein Classification

3',5'-cyclic nucleotide phosphodiesterase( domain architecture ID 10446396)

3',5'-cyclic nucleotide phosphodiesterase catalyzes the hydrolysis of cAMP or cGMP to produce adenosine 5'-phosphate or guanosine 5'-phosphate, respectively

CATH:  1.10.1300.10
EC:  3.1.4.-
Gene Ontology:  GO:0046872|GO:0004114
PubMed:  11008484|9868367
SCOP:  4001423

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
251-502 3.77e-82

3'5'-cyclic nucleotide phosphodiesterase;


:

Pssm-ID: 459723  Cd Length: 238  Bit Score: 256.71  E-value: 3.77e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  251 YHNRIHAADVLHGCYYlsahpvrstFLTPKTPDSVLTPphphhqhssimsqlstLELMALFTAAAMHDYDHPGRTNAFLV 330
Cdd:pfam00233   1 YHNWRHAFDVTQTMYY---------LLKTGKLKEVLTD----------------LEILALLIAALCHDVDHPGTNNAFLI 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  331 QVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTE---- 406
Cdd:pfam00233  56 KTKSPLAILYNDSSVLENHHCATAFQILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktl 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  407 -IDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQ-VAKLQDSFIAH 484
Cdd:pfam00233 136 dFLENEEDRRLLLLSMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREKKTsLPKSQIGFIDF 215
                         250
                  ....*....|....*...
gi 808355496  485 VVSPLATAMNEcgLLPIL 502
Cdd:pfam00233 216 IVLPLFEALAK--LFPEL 231
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
251-502 3.77e-82

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 256.71  E-value: 3.77e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  251 YHNRIHAADVLHGCYYlsahpvrstFLTPKTPDSVLTPphphhqhssimsqlstLELMALFTAAAMHDYDHPGRTNAFLV 330
Cdd:pfam00233   1 YHNWRHAFDVTQTMYY---------LLKTGKLKEVLTD----------------LEILALLIAALCHDVDHPGTNNAFLI 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  331 QVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTE---- 406
Cdd:pfam00233  56 KTKSPLAILYNDSSVLENHHCATAFQILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktl 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  407 -IDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQ-VAKLQDSFIAH 484
Cdd:pfam00233 136 dFLENEEDRRLLLLSMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREKKTsLPKSQIGFIDF 215
                         250
                  ....*....|....*...
gi 808355496  485 VVSPLATAMNEcgLLPIL 502
Cdd:pfam00233 216 IVLPLFEALAK--LFPEL 231
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
302-450 4.82e-08

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 52.34  E-value: 4.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496 302 LSTLELMALFTAAAMHDYDHPGRTNAFlvqvedkkailYNDRSVLENHHAAESWKLLNKPENHFIENLdPAEMkrfrylv 381
Cdd:cd00077   23 LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAEILRELLLEEVIKL-IDEL------- 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808355496 382 leyILATDLKqHFEIIMTFTerlteIDVQVETDRLLIGKLLIKMADI--NSPTKPYGLHRQWTDRICEEFY 450
Cdd:cd00077   84 ---ILAVDAS-HHERLDGLG-----YPDGLKGEEITLEARIVKLADRldALRRDSREKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
289-441 4.41e-06

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 46.14  E-value: 4.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496   289 PHPHHQHSSIMSQLS--------TLELMALFTAAAMHDYDHPGRTNAFLVqvedkkailynDRSVLENHHAAESWKLLNK 360
Cdd:smart00471   2 DYHVFEHSLRVAQLAaalaeelgLLDIELLLLAALLHDIGKPGTPDSFLV-----------KTSVLEDHHFIGAEILLEE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496   361 PENHFIENldpaemkrfrylvleyILATDLKQHFEIIMTfterlteidvqVETDRLLIGKLLIKMADINSPTKPYGLHRQ 440
Cdd:smart00471  71 EEPRILEE----------------ILRTAILSHHERPDG-----------LRGEPITLEARIVKVADRLDALRADRRYRR 123

                   .
gi 808355496   441 W 441
Cdd:smart00471 124 V 124
 
Name Accession Description Interval E-value
PDEase_I pfam00233
3'5'-cyclic nucleotide phosphodiesterase;
251-502 3.77e-82

3'5'-cyclic nucleotide phosphodiesterase;


Pssm-ID: 459723  Cd Length: 238  Bit Score: 256.71  E-value: 3.77e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  251 YHNRIHAADVLHGCYYlsahpvrstFLTPKTPDSVLTPphphhqhssimsqlstLELMALFTAAAMHDYDHPGRTNAFLV 330
Cdd:pfam00233   1 YHNWRHAFDVTQTMYY---------LLKTGKLKEVLTD----------------LEILALLIAALCHDVDHPGTNNAFLI 55
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  331 QVEDKKAILYNDRSVLENHHAAESWKLLNKPENHFIENLDPAEMKRFRYLVLEYILATDLKQHFEIIMTFTERLTE---- 406
Cdd:pfam00233  56 KTKSPLAILYNDSSVLENHHCATAFQILQDEECNIFSNLSDEEYKEVRKLIISLILATDMAKHFELLKKFKSLLESkktl 135
                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496  407 -IDVQVETDRLLIGKLLIKMADINSPTKPYGLHRQWTDRICEEFYEQGDDERRRGLPITPYMDRGDAQ-VAKLQDSFIAH 484
Cdd:pfam00233 136 dFLENEEDRRLLLLSMLIKAADISNPTRPWEISKKWADLVAEEFFRQGDLEKELGLPVSPLMDREKKTsLPKSQIGFIDF 215
                         250
                  ....*....|....*...
gi 808355496  485 VVSPLATAMNEcgLLPIL 502
Cdd:pfam00233 216 IVLPLFEALAK--LFPEL 231
HDc cd00077
Metal dependent phosphohydrolases with conserved 'HD' motif
302-450 4.82e-08

Metal dependent phosphohydrolases with conserved 'HD' motif


Pssm-ID: 238032 [Multi-domain]  Cd Length: 145  Bit Score: 52.34  E-value: 4.82e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496 302 LSTLELMALFTAAAMHDYDHPGRTNAFlvqvedkkailYNDRSVLENHHAAESWKLLNKPENHFIENLdPAEMkrfrylv 381
Cdd:cd00077   23 LSEEDIELLRLAALLHDIGKPGTPDAI-----------TEEESELEKDHAIVGAEILRELLLEEVIKL-IDEL------- 83
                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 808355496 382 leyILATDLKqHFEIIMTFTerlteIDVQVETDRLLIGKLLIKMADI--NSPTKPYGLHRQWTDRICEEFY 450
Cdd:cd00077   84 ---ILAVDAS-HHERLDGLG-----YPDGLKGEEITLEARIVKLADRldALRRDSREKRRRIAEEDLEELL 145
HDc smart00471
Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic ...
289-441 4.41e-06

Metal dependent phosphohydrolases with conserved 'HD' motif; Includes eukaryotic cyclic nucleotide phosphodiesterases (PDEc). This profile/HMM does not detect HD homologues in bacterial glycine aminoacyl-tRNA synthetases (beta subunit).


Pssm-ID: 214679 [Multi-domain]  Cd Length: 124  Bit Score: 46.14  E-value: 4.41e-06
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496   289 PHPHHQHSSIMSQLS--------TLELMALFTAAAMHDYDHPGRTNAFLVqvedkkailynDRSVLENHHAAESWKLLNK 360
Cdd:smart00471   2 DYHVFEHSLRVAQLAaalaeelgLLDIELLLLAALLHDIGKPGTPDSFLV-----------KTSVLEDHHFIGAEILLEE 70
                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 808355496   361 PENHFIENldpaemkrfrylvleyILATDLKQHFEIIMTfterlteidvqVETDRLLIGKLLIKMADINSPTKPYGLHRQ 440
Cdd:smart00471  71 EEPRILEE----------------ILRTAILSHHERPDG-----------LRGEPITLEARIVKVADRLDALRADRRYRR 123

                   .
gi 808355496   441 W 441
Cdd:smart00471 124 V 124
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH