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Conserved domains on  [gi|1676324824|ref|NP_001292871|]
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ubiquinone biosynthesis protein COQ4 homolog, mitochondrial isoform 2 precursor [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Coq4 super family cl47909
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 46-67 1.96e-05

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


The actual alignment was detected with superfamily member pfam05019:

Pssm-ID: 461522  Cd Length: 213  Bit Score: 40.93  E-value: 1.96e-05
                          10        20
                  ....*....|....*....|..
gi 1676324824  46 PLQKGLLAAGSAAMALYNPYRH 67
Cdd:pfam05019   1 PLEKLLLAVGSAIGALLDPERG 22
 
Name Accession Description Interval E-value
Coq4 pfam05019
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 46-67 1.96e-05

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


Pssm-ID: 461522  Cd Length: 213  Bit Score: 40.93  E-value: 1.96e-05
                          10        20
                  ....*....|....*....|..
gi 1676324824  46 PLQKGLLAAGSAAMALYNPYRH 67
Cdd:pfam05019   1 PLEKLLLAVGSAIGALLDPERG 22
 
Name Accession Description Interval E-value
Coq4 pfam05019
Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate ...
 46-67 1.96e-05

Coenzyme Q (ubiquinone) biosynthesis protein Coq4; Coq4p was shown to peripherally associate with the matrix face of the mitochondrial inner membrane. The putative mitochondrial- targeting sequence present at the amino-terminus of the polypeptide efficiently imported it to mitochondria. The function of Coq4p is unknown, although its presence is required to maintain a steady-state level of Coq7p, another component of the Q biosynthetic pathway. The overall structure of Coq4 is alpha helical and shows resemblance to haemoglobin/myoglobin (information from TOPSAN).


Pssm-ID: 461522  Cd Length: 213  Bit Score: 40.93  E-value: 1.96e-05
                          10        20
                  ....*....|....*....|..
gi 1676324824  46 PLQKGLLAAGSAAMALYNPYRH 67
Cdd:pfam05019   1 PLEKLLLAVGSAIGALLDPERG 22
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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