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Conserved domains on  [gi|756992492|ref|NP_001291946|]
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dynein light chain roadblock-type 2 isoform 2 [Homo sapiens]

Protein Classification

roadblock/LC7 domain-containing protein( domain architecture ID 10505491)

roadblock/LC7 domain-containing protein similar to Homo sapiens dynein light chain roadblock-type 1 and 2, and ragulator complex protein LAMTOR2

CATH:  3.30.450.30
PubMed:  10402468|11084347

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 32-122 1.39e-26

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


:

Pssm-ID: 397386  Cd Length: 91  Bit Score: 94.62  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756992492   32 EVEETLKRIQSHKGVIGTMVVNAEGIPIRT-TLDNSTTVQYAGLLHHLTMKAKSTVRDIDpQNDLTFLRIRSKKHEIMVA 110
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASsTLDNDDADHLAALASGLLSAAKGAARDLG-SGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 756992492  111 PDKEYLLIVIQN 122
Cdd:pfam03259  80 PAGEGALLVVLA 91
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 32-122 1.39e-26

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 94.62  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756992492   32 EVEETLKRIQSHKGVIGTMVVNAEGIPIRT-TLDNSTTVQYAGLLHHLTMKAKSTVRDIDpQNDLTFLRIRSKKHEIMVA 110
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASsTLDNDDADHLAALASGLLSAAKGAARDLG-SGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 756992492  111 PDKEYLLIVIQN 122
Cdd:pfam03259  80 PAGEGALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 33-120 1.69e-24

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 89.17  E-value: 1.69e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756992492    33 VEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTV-QYAGLLHHLTMKAKSTVRDIDpQNDLTFLRIRSKKHEIMVAP 111
Cdd:smart00960   1 IEELLDLLARVPGVRGALVVSRDGLLLASSGLSDDDAeRLAALAAGLLSLAERAARELG-EGELRQLRIEGEKGEVLITP 79


                   ....*....
gi 756992492   112 DKEYLLIVI 120
Cdd:smart00960  80 AGDALLAVL 88
 
Name Accession Description Interval E-value
Robl_LC7 pfam03259
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 32-122 1.39e-26

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 397386  Cd Length: 91  Bit Score: 94.62  E-value: 1.39e-26
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756992492   32 EVEETLKRIQSHKGVIGTMVVNAEGIPIRT-TLDNSTTVQYAGLLHHLTMKAKSTVRDIDpQNDLTFLRIRSKKHEIMVA 110
Cdd:pfam03259   1 LDEELLDLLQRVPGVRGALVVSKDGLVIASsTLDNDDADHLAALASGLLSAAKGAARDLG-SGELRQLLIEGKKGELYLT 79

                          90
                  ....*....|..
gi 756992492  111 PDKEYLLIVIQN 122
Cdd:pfam03259  80 PAGEGALLVVLA 91
Robl_LC7 smart00960
Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and ...
 33-120 1.69e-24

Roadblock/LC7 domain; This family includes proteins that are about 100 amino acids long and have been shown to be related. Members of this family of proteins are associated with both flagellar outer arm dynein and Drosophila and rat brain cytoplasmic dynein. It is proposed that roadblock/LC7 family members may modulate specific dynein functions. This family also includes Golgi-associated MP1 adapter protein and MglB from Myxococcus xanthus, a protein involved in gliding motility. However the family also includes members from non-motile bacteria such as Streptomyces coelicolor, suggesting that the protein may play a structural or regulatory role.


Pssm-ID: 214939  Cd Length: 88  Bit Score: 89.17  E-value: 1.69e-24
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 756992492    33 VEETLKRIQSHKGVIGTMVVNAEGIPIRTTLDNSTTV-QYAGLLHHLTMKAKSTVRDIDpQNDLTFLRIRSKKHEIMVAP 111
Cdd:smart00960   1 IEELLDLLARVPGVRGALVVSRDGLLLASSGLSDDDAeRLAALAAGLLSLAERAARELG-EGELRQLRIEGEKGEVLITP 79


                   ....*....
gi 756992492   112 DKEYLLIVI 120
Cdd:smart00960  80 AGDALLAVL 88
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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