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Conserved domains on  [gi|754502046|ref|NP_001291692|]
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zinc finger protein 687 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1133-1159 9.87e-10

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


:

Pssm-ID: 465205  Cd Length: 27  Bit Score: 54.74  E-value: 9.87e-10
                           10        20
                   ....*....|....*....|....*..
gi 754502046  1133 GAQQCLDCGLCFASPGSLSRHRFISHK 1159
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
PHA03247 super family cl33720
large tegument protein UL36; Provisional
 54-294 1.18e-06

large tegument protein UL36; Provisional


The actual alignment was detected with superfamily member PHA03247:

Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   54 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 133
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  134 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 194
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  195 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 271
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                         250       260
                  ....*....|....*....|....*
gi 754502046  272 PLASPKVP--VCQPLKEEDDDEGPV 294
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
zf-C2H2_8 super family cl25789
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 795-877 5.48e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


The actual alignment was detected with superfamily member pfam15909:

Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.78  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   795 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 872
Cdd:pfam15909    5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81


                   ....*
gi 754502046   873 MLEHL 877
Cdd:pfam15909   82 LFKHL 86
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1133-1159 9.87e-10

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 54.74  E-value: 9.87e-10
                           10        20
                   ....*....|....*....|....*..
gi 754502046  1133 GAQQCLDCGLCFASPGSLSRHRFISHK 1159
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-294 1.18e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   54 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 133
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  134 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 194
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  195 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 271
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                         250       260
                  ....*....|....*....|....*
gi 754502046  272 PLASPKVP--VCQPLKEEDDDEGPV 294
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-279 1.97e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046    72 HGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQngfgsPEPSLP-GTPHSPAPPSggtwk 150
Cdd:pfam03154  291 HPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQ-----PLPPAPlSMPHIKPPPT----- 360

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   151 ekgmegkTPLDLFahfgPEPGDHSDPLPPSAPSPTREGALTPPPfPSSFELAQEngPGMQPPVSSPPLGALKQES----C 226
Cdd:pfam03154  361 -------TPIPQL----PNPQSHKHPPHLSGPSPFQMNSNLPPP-PALKPLSSL--STHHPPSAHPPPLQLMPQSqqlpP 426

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 754502046   227 SPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQS--PGHQSPLASPKVP 279
Cdd:pfam03154  427 PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGP 481
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 795-877 5.48e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.78  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   795 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 872
Cdd:pfam15909    5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81


                   ....*
gi 754502046   873 MLEHL 877
Cdd:pfam15909   82 LFKHL 86
 
Name Accession Description Interval E-value
zf-C2H2_11 pfam16622
zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.
 1133-1159 9.87e-10

zinc-finger C2H2-type; Zinc-finger of C2H2 type found in higher eukaryotes.


Pssm-ID: 465205  Cd Length: 27  Bit Score: 54.74  E-value: 9.87e-10
                           10        20
                   ....*....|....*....|....*..
gi 754502046  1133 GAQQCLDCGLCFASPGSLSRHRFISHK 1159
Cdd:pfam16622    1 STCQCLLCGLCFTSQGSLSRHLFIVHK 27
PHA03247 PHA03247
large tegument protein UL36; Provisional
 54-294 1.18e-06

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 53.40  E-value: 1.18e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   54 TAAASAGDGPGVPAQASDHGLPPPdiSVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNgfgSPEPS 133
Cdd:PHA03247 2763 TAGPPAPAPPAAPAAGPPRRLTRP--AVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAGPLPPPT---SAQPT 2837

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  134 LPGTPHSPAPPS---------GGTWKEKGMEGKT----------PLDLFAHFGPEPGDHSDPLPPSAPSPTREGALTPPP 194
Cdd:PHA03247 2838 APPPPPGPPPPSlplggsvapGGDVRRRPPSRSPaakpaaparpPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPP 2917

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  195 FPSSFE--LAQENGPGMQPPVSSPPLGALKQESCSPH-HPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQS 271
Cdd:PHA03247 2918 QPQPQPppPPQPQPPPPPPPRPQPPLAPTTDPAGAGEpSGAVPQPWLGALVPGRVAVPRFRVPQPAPSREAPASSTPPLT 2997

                         250       260
                  ....*....|....*....|....*
gi 754502046  272 PLASPKVP--VCQPLKEEDDDEGPV 294
Cdd:PHA03247 2998 GHSLSRVSswASSLALHEETDPPPV 3022
PHA03247 PHA03247
large tegument protein UL36; Provisional
 75-293 7.15e-05

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 47.63  E-value: 7.15e-05
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   75 PPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGM 154
Cdd:PHA03247 2706 PTPEPAPHALVSATPLPPGPAAARQASPALPAAPAPPAVPAGPATPGGPARPARPPTTAGPPAPAPPAAPAAGPPRRLTR 2785

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  155 EGKTPLDLFAHFGPEPGDHSD-PLPPSAPSPTREGALTP----PPFPSSFELAQENGPGMQPPVSSP-----PLGALKQE 224
Cdd:PHA03247 2786 PAVASLSESRESLPSPWDPADpPAAVLAPAAALPPAASPagplPPPTSAQPTAPPPPPGPPPPSLPLggsvaPGGDVRRR 2865

                         170       180       190       200       210       220
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 754502046  225 SCSPHHPQVLAqqgSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASPKVPVCQPLKEEDDDEGP 293
Cdd:PHA03247 2866 PPSRSPAAKPA---APARPPVRRLARPAVSRSTESFALPPDQPERPPQPQAPPPPQPQPQPPPPPQPQP 2931
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 72-279 1.97e-04

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 45.91  E-value: 1.97e-04
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046    72 HGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRMQngfgsPEPSLP-GTPHSPAPPSggtwk 150
Cdd:pfam03154  291 HPVPPQPFPLTPQSSQSQVPPGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQ-----PLPPAPlSMPHIKPPPT----- 360

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   151 ekgmegkTPLDLFahfgPEPGDHSDPLPPSAPSPTREGALTPPPfPSSFELAQEngPGMQPPVSSPPLGALKQES----C 226
Cdd:pfam03154  361 -------TPIPQL----PNPQSHKHPPHLSGPSPFQMNSNLPPP-PALKPLSSL--STHHPPSAHPPPLQLMPQSqqlpP 426

                          170       180       190       200       210
                   ....*....|....*....|....*....|....*....|....*....|....*
gi 754502046   227 SPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQS--PGHQSPLASPKVP 279
Cdd:pfam03154  427 PPAQPPVLTQSQSLPPPAASHPPTSGLHQVPSQSPFPQHPfvPGGPPPITPPSGP 481
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 100-331 3.04e-04

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 45.16  E-value: 3.04e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  100 GGSAGDGAQAAGVTKEGPVGPHRMQNGfgsPEPSLPGTPHSPAPPSGGTWKEKGmegKTPLDLFAHFGPEPGDH-SDPLP 178
Cdd:PHA03307   44 VSDSAELAAVTVVAGAAACDRFEPPTG---PPPGPGTEAPANESRSTPTWSLST---LAPASPAREGSPTPPGPsSPDPP 117

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  179 PSAPSPTREGALTPPPFPSSFELAQENGPGMQPPVSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASASPPPVA 258
Cdd:PHA03307  118 PPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSPEETARAPSSPPAEPPPST 197

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 754502046  259 GVPFFKQSPGHQSPLASPKVPVCQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKVR 331
Cdd:PHA03307  198 PPAAASPRPPRRSSPISASASSPAPAPGRSAADDAGASSSDSSSSESSGCGWGPENECPLPRPAPITLPTRIW 270
PHA03247 PHA03247
large tegument protein UL36; Provisional
 29-358 4.16e-04

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 44.93  E-value: 4.16e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   29 SGPEENEGPGGPGKPEPGVGSES-----------------EDTAAASAGD-----GPGVPAQASDHGLPPPDISvvsviv 86
Cdd:PHA03247 2501 GGPPDPDAPPAPSRLAPAILPDEpvgepvhprmltwirglEELASDDAGDpppplPPAAPPAAPDRSVPPPRPA------ 2574

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   87 kntvcPEQSEALAGGSAG-DGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPGTPHSPAPPSGGTWKEKGMEGKTPldlfAH 165
Cdd:PHA03247 2575 -----PRPSEPAVTSRARrPDAPPQSARPRAPVDDRGDPRGPAPPSPLPPDTHAPDPPPPSPSPAANEPDPHPP----PT 2645

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  166 FGPEPGDHSDPLPPSAPSPTREGALTPPPFPSSfELAQENGPGMQPPVSS----------PPLGALKQESCSPHHPQVLA 235
Cdd:PHA03247 2646 VPPPERPRDDPAPGRVSRPRRARRLGRAAQASS-PPQRPRRRAARPTVGSltsladppppPPTPEPAPHALVSATPLPPG 2724

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  236 QQGSGSSPKATdiPASASPPPVAGVPffkQSPGHQSPLASPKVPV--CQPLKEEDDDEGPVDKSSPGSPQSPSSGAEAAD 313
Cdd:PHA03247 2725 PAAARQASPAL--PAAPAPPAVPAGP---ATPGGPARPARPPTTAgpPAPAPPAAPAAGPPRRLTRPAVASLSESRESLP 2799

                         330       340       350       360
                  ....*....|....*....|....*....|....*....|....*
gi 754502046  314 EDSNDSPASSSSRPLKVRIKTIKTSCGNITRTVTQVPSDPDPPAP 358
Cdd:PHA03247 2800 SPWDPADPPAAVLAPAAALPPAASPAGPLPPPTSAQPTAPPPPPG 2844
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 49-272 1.11e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 43.22  E-value: 1.11e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046    49 SESEDTAAASAGDGPGVPAQASDHGLPPPDISVVSVIVKNTVCPEQSEALAGGSAGDGAQAAGVTKEGPVGPHRM-QNGF 127
Cdd:pfam03154  156 SDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATAGPTPSAPSVPPQGSPATSQPPNQTQSTAAPHTLiQQTP 235

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   128 GSPEPSLPgTPHSPAPPSggtwkekgMEGKTPLDLFAHFGPEPGDHSdPLPPsAPSPTREG------ALTPPPFPSSFEL 201
Cdd:pfam03154  236 TLHPQRLP-SPHPPLQPM--------TQPPPPSQVSPQPLPQPSLHG-QMPP-MPHSLQTGpshmqhPVPPQPFPLTPQS 304

                          170       180       190       200       210       220       230
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 754502046   202 AQENGPgmqppvSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPASA------SPPPVAGVPFFKQSPGHQSP 272
Cdd:pfam03154  305 SQSQVP------PGPSPAAPGQSQQRIHTPPSQSQLQSQQPPREQPLPPAPlsmphiKPPPTTPIPQLPNPQSHKHP 375
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 135-280 1.39e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 43.14  E-value: 1.39e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  135 PGTPHSPAPPSGGTWKEKGMEGktpldlfaHFGPEPGDHSdPLPPSAPSPTREGALTPPPFPssfelAQENGPGMQPPVS 214
Cdd:PTZ00449  511 PEGPEASGLPPKAPGDKEGEEG--------EHEDSKESDE-PKEGGKPGETKEGEVGKKPGP-----AKEHKPSKIPTLS 576

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 754502046  215 SPPLGALKqescsPHHPQVLAQQGSGSSPKATDIPASASPPPVAGVPFFKQSPGHQSPLASPKVPV 280
Cdd:PTZ00449  577 KKPEFPKD-----PKHPKDPEEPKKPKRPRSAQRPTRPKSPKLPELLDIPKSPKRPESPKSPKRPP 637
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 104-273 1.55e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 42.83  E-value: 1.55e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   104 GDGAQAAGVTKEGPVGPHRMQNGFGSPEPSLPgTPHSPAPPSGGTWKEKGMEGKtPLDLFAHFGPEPgdhsdPLPPSAPS 183
Cdd:pfam03154  118 GESSDGRSVNDEGSSDPKDIDQDNRSTSPSIP-SPQDNESDSDSSAQQQILQTQ-PPVLQAQSGAAS-----PPSPPPPG 190

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   184 PTREGALTPPPFPSSFelaqengpgmqPPVSSPPLGALKQESCSPHHPQVLAQQGSG------SSPKATDIPASASPPPV 257
Cdd:pfam03154  191 TTQAATAGPTPSAPSV-----------PPQGSPATSQPPNQTQSTAAPHTLIQQTPTlhpqrlPSPHPPLQPMTQPPPPS 259

                          170
                   ....*....|....*.
gi 754502046   258 AGVPFFKQSPGHQSPL 273
Cdd:pfam03154  260 QVSPQPLPQPSLHGQM 275
zf-C2H2_8 pfam15909
C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.
 795-877 5.48e-03

C2H2-type zinc ribbon; This family carries three zinc-fingers in tandem.


Pssm-ID: 464935 [Multi-domain]  Cd Length: 98  Bit Score: 37.78  E-value: 5.48e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   795 PICPMAFKSGPSAHAHLYSQHPSFQTQQAKLiYKCAM--CDTVFTHKPLLSSHFDQHLLPQRVsvFKCPSCPLLFAQKRT 872
Cdd:pfam15909    5 PGCCLSFPSVRDLAQHLRTHCPPTQSLEGKL-FRCSAlsCTETFPSMQELVAHSKLHYKPNRY--FKCENCLLRFRTHRS 81


                   ....*
gi 754502046   873 MLEHL 877
Cdd:pfam15909   82 LFKHL 86
PHA03247 PHA03247
large tegument protein UL36; Provisional
 128-532 5.75e-03

large tegument protein UL36; Provisional


Pssm-ID: 223021 [Multi-domain]  Cd Length: 3151  Bit Score: 41.08  E-value: 5.75e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  128 GSPEPSLPGTPHSPAP------------PSGGTWKEKGMEGKTPLDlfAHFGPEPGDHSDPLP---PSAPSPTREGALTP 192
Cdd:PHA03247 2549 GDPPPPLPPAAPPAAPdrsvppprpaprPSEPAVTSRARRPDAPPQ--SARPRAPVDDRGDPRgpaPPSPLPPDTHAPDP 2626

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  193 PPF---PSSFELAqENGPGMQPPVSSPPLGALKQESCSPHHPQVLAQQGSGSSPKATDIPaSASPPPVAGVPFFKQSPgh 269
Cdd:PHA03247 2627 PPPspsPAANEPD-PHPPPTVPPPERPRDDPAPGRVSRPRRARRLGRAAQASSPPQRPRR-RAARPTVGSLTSLADPP-- 2702

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  270 qsplASPKVPVCQPlkeedddegpvdkSSPGSPQSPSSGAEAADEDSNDSPASSSSRPLKvriKTIKTSCGNITRTVTQV 349
Cdd:PHA03247 2703 ----PPPPTPEPAP-------------HALVSATPLPPGPAAARQASPALPAAPAPPAVP---AGPATPGGPARPARPPT 2762

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  350 PSDPDPPAPlaegaflaeasllklsPATPTSEGPKVVSVQLGDGTRLKGTVLPVATIQNASTAMLMAASVARKAVVLPGG 429
Cdd:PHA03247 2763 TAGPPAPAP----------------PAAPAAGPPRRLTRPAVASLSESRESLPSPWDPADPPAAVLAPAAALPPAASPAG 2826

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  430 TATSPKMIAKnvlglVPQALPKADGRAGLGTGGQKVNGASVVMVQPSK-TATGPSTGGGTVISRTQsslveafnkilnsk 508
Cdd:PHA03247 2827 PLPPPTSAQP-----TAPPPPPGPPPPSLPLGGSVAPGGDVRRRPPSRsPAAKPAAPARPPVRRLA-------------- 2887

                         410       420
                  ....*....|....*....|....
gi 754502046  509 nllpayRPNLSPPAEAgLALPPTG 532
Cdd:PHA03247 2888 ------RPAVSRSTES-FALPPDQ 2904
TALPID3 pfam15324
Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for ...
 129-276 5.90e-03

Hedgehog signalling target; TALPID3 is a family of eukaryotic proteins that are targets for Hedgehog signalling. Mutations in this gene noticed first in chickens lead to multiple abnormalities of development.


Pssm-ID: 434634 [Multi-domain]  Cd Length: 1288  Bit Score: 41.03  E-value: 5.90e-03
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   129 SPEPSLPGTPHSPA--------PPSggTWKEKGMEGKTPLDLFAHFGPEPGDHSDPL-PPSA---PSPTREGALTPPPFP 196
Cdd:pfam15324  990 TPQPTPPCSPPSPLkepspvktPDS--SPCVSEHDFFPVKEIPPEKGADTGPAVSLViTPTVtpiATPPPAATPTPPLSE 1067

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046   197 SSFELAQENGPGMQPPVSSPPLgALKQESCSP-----HHPQVLAQQGSGSSPKATDIPAS-ASPPPVAGVPFFKQSPghq 270
Cdd:pfam15324 1068 NSIDKLKSPSPELPKPWEDSDL-PLEEENPNSeqeelHPRAVVMSVARDEEPESVVLPASpPEPKPLAPPPLGAAPP--- 1143


                   ....*.
gi 754502046   271 SPLASP 276
Cdd:pfam15324 1144 SPPQSP 1149
PTZ00449 PTZ00449
104 kDa microneme/rhoptry antigen; Provisional
 117-261 7.09e-03

104 kDa microneme/rhoptry antigen; Provisional


Pssm-ID: 185628 [Multi-domain]  Cd Length: 943  Bit Score: 40.83  E-value: 7.09e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  117 PVGPHRMQngfGSPEPSLPGTPHSPAPPSGGTWKEK-----------GMEGKTPLDLFAHFG-------PE----PGDHS 174
Cdd:PTZ00449  642 PSSPERPE---GPKIIKSPKPPKSPKPPFDPKFKEKfyddyldaaakSKETKTTVVLDESFEsilketlPEtpgtPFTTP 718

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 754502046  175 DPLPPSAPSpTREGALTPP-------PFPSSFELAQENGPGM--QPPVSSPPLGALKQEScspHHPQVLAQQGSGSSP-K 244
Cdd:PTZ00449  719 RPLPPKLPR-DEEFPFEPIgdpdaeqPDDIEFFTPPEEERTFfhETPADTPLPDILAEEF---KEEDIHAETGEPDEAmK 794

                         170
                  ....*....|....*..
gi 754502046  245 ATDIPASASPPPVAGVP 261
Cdd:PTZ00449  795 RPDSPSEHEDKPPGDHP 811
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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