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Conserved domains on  [gi|749385058|ref|NP_001291321|]
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fractalkine isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRK10263 super family cl35903
DNA translocase FtsK; Provisional
 44-217 1.41e-03

DNA translocase FtsK; Provisional


The actual alignment was detected with superfamily member PRK10263:

Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058   44 PEATGESSSLEPTPSSQEAqralgTSPELPTGVTGSSGTRLPPTPKaqdggpvgtelFRVPPVSTAATWQSSAPHQPGPS 123
Cdd:PRK10263  345 PVASVDVPPAQPTVAWQPV-----PGPQTGEPVIAPAPEGYPQQSQ-----------YAQPAVQYNEPLQQPVQPQQPYY 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058  124 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQ----SPRPENSLEREEMGPVPAHTDAFQDWGPGSMA 199
Cdd:PRK10263  409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstfAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQP 488

                         170
                  ....*....|....*...
gi 749385058  200 HVSVVPVSSEGTPSREPV 217
Cdd:PRK10263  489 VVEPEPVVEETKPARPPL 506
Chemokine super family cl00134
Chemokine: small cytokines, including a number of secreted growth factors and interferons ...
 1-15 3.32e-03

Chemokine: small cytokines, including a number of secreted growth factors and interferons involved in mitogenic, chemotactic, and inflammatory activity; distinguished from other cytokines by their receptors, which are G-protein coupled receptors; divided into 4 subfamilies based on the arrangement of the two N-terminal cysteines; some members can bind multiple receptors and many chemokine receptors can bind more than one chemokine; this redundancy allows precise control in stimulating the immune system and in contributing to the homeostasis of a cell; when expressed inappropriately, chemokines play a role in autoimmune diseases, vascular irregularities, graft rejection, neoplasia, and allergies; exist as monomers, dimers and multimers, but are believed to function as monomers; found only in vertebrates and a few viruses. See CDs: Chemokine_CXC (cd00273), Chemokine_CC (cd00272), Chemokine_C (cd00271), and Chemokine_CX3C (cd00274) for chemokine subgroups.


The actual alignment was detected with superfamily member cd00274:

Pssm-ID: 469625  Cd Length: 76  Bit Score: 35.81  E-value: 3.32e-03
                         10
                 ....*....|....*
gi 749385058   1 MQHLDRQAAALTRNG 15
Cdd:cd00274   62 MQHLDRQAAALTRNG 76
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 44-217 1.41e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058   44 PEATGESSSLEPTPSSQEAqralgTSPELPTGVTGSSGTRLPPTPKaqdggpvgtelFRVPPVSTAATWQSSAPHQPGPS 123
Cdd:PRK10263  345 PVASVDVPPAQPTVAWQPV-----PGPQTGEPVIAPAPEGYPQQSQ-----------YAQPAVQYNEPLQQPVQPQQPYY 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058  124 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQ----SPRPENSLEREEMGPVPAHTDAFQDWGPGSMA 199
Cdd:PRK10263  409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstfAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQP 488

                         170
                  ....*....|....*...
gi 749385058  200 HVSVVPVSSEGTPSREPV 217
Cdd:PRK10263  489 VVEPEPVVEETKPARPPL 506
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 1-15 3.32e-03

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 35.81  E-value: 3.32e-03
                         10
                 ....*....|....*
gi 749385058   1 MQHLDRQAAALTRNG 15
Cdd:cd00274   62 MQHLDRQAAALTRNG 76
 
Name Accession Description Interval E-value
PRK10263 PRK10263
DNA translocase FtsK; Provisional
 44-217 1.41e-03

DNA translocase FtsK; Provisional


Pssm-ID: 236669 [Multi-domain]  Cd Length: 1355  Bit Score: 40.45  E-value: 1.41e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058   44 PEATGESSSLEPTPSSQEAqralgTSPELPTGVTGSSGTRLPPTPKaqdggpvgtelFRVPPVSTAATWQSSAPHQPGPS 123
Cdd:PRK10263  345 PVASVDVPPAQPTVAWQPV-----PGPQTGEPVIAPAPEGYPQQSQ-----------YAQPAVQYNEPLQQPVQPQQPYY 408

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058  124 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRVWGQGQ----SPRPENSLEREEMGPVPAHTDAFQDWGPGSMA 199
Cdd:PRK10263  409 APAAEQPAQQPYYAPAPEQPAQQPYYAPAPEQPVAGNAWQAEEQqstfAPQSTYQTEQTYQQPAAQEPLYQQPQPVEQQP 488

                         170
                  ....*....|....*...
gi 749385058  200 HVSVVPVSSEGTPSREPV 217
Cdd:PRK10263  489 VVEPEPVVEETKPARPPL 506
dnaA PRK14086
chromosomal replication initiator protein DnaA;
46-239 1.50e-03

chromosomal replication initiator protein DnaA;


Pssm-ID: 237605 [Multi-domain]  Cd Length: 617  Bit Score: 40.19  E-value: 1.50e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058  46 ATGESSSLEPTPSSQEAQRAlgTSPELPT-GVTGSSGTRLPPTPKAQDGGPVGTELFRVPPVSTAATWQSS-APHQPGPS 123
Cdd:PRK14086  86 ITVDPSAGEPAPPPPHARRT--SEPELPRpGRRPYEGYGGPRADDRPPGLPRQDQLPTARPAYPAYQQRPEpGAWPRAAD 163

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058 124 LWAEAKTSEAPSTQDPSTQASTASSPAPEENAPSEGQRV-----WGQGQSPRPE----NSLEREEMGPVPAHTDAFQDWG 194
Cdd:PRK14086 164 DYGWQQQRLGFPPRAPYASPASYAPEQERDREPYDAGRPeydqrRRDYDHPRPDwdrpRRDRTDRPEPPPGAGHVHRGGP 243

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....*
gi 749385058 195 PGSMAHVSVVPVSSEGTPSREPvASGSWTPKAEEPiHATMDPQRL 239
Cdd:PRK14086 244 GPPERDDAPVVPIRPSAPGPLA-AQPAPAPGPGEP-TARLNPKYT 286
Chemokine_CX3C cd00274
Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal ...
 1-15 3.32e-03

Chemokine_CX3C: 1 of 4 subgroup designations based on the arrangement of the two N-terminal cysteines; differ structurally from the other subgroups in that they are attached to a membrane-spanning domain via a mucin-like stalk and can be proteolytically cleaved to a freely diffusible form; chemotatic for T cells, monocytes, and natural killer cells; function as monomers and are found only in vertebrates and a few viruses; currently only fractalkine (sometimes called neurotactin) has been identified as a member of this subfamily; the primary source of fractalkine is neurons, and they exhibit cell adhesion and chemoattractive properties in the central nervous system. See CDs: Chemokine (cd00169) for the general alignment of chemokines, or Chemokine_CXC (cd00273), Chemokine_CC (cd00272), and Chemokine_C (cd00271) for the additional chemokine subgroups.


Pssm-ID: 238172  Cd Length: 76  Bit Score: 35.81  E-value: 3.32e-03
                         10
                 ....*....|....*
gi 749385058   1 MQHLDRQAAALTRNG 15
Cdd:cd00274   62 MQHLDRQAAALTRNG 76
PHA03307 PHA03307
transcriptional regulator ICP4; Provisional
 27-232 7.29e-03

transcriptional regulator ICP4; Provisional


Pssm-ID: 223039 [Multi-domain]  Cd Length: 1352  Bit Score: 38.23  E-value: 7.29e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058   27 PRTTPAAGGMDESVVLEPEATGESSSLEPTPSSQEAQRALGTSPELPTGVTGSSGTRLPPTPKAQDGGPVGTELFRVPPV 106
Cdd:PHA03307  100 PAREGSPTPPGPSSPDPPPPTPPPASPPPSPAPDLSEMLRPVGSPGPPPAASPPAAGASPAAVASDAASSRQAALPLSSP 179

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 749385058  107 STAATWQSSAPHQPGPSLWAEAKTSEAPSTQDPSTQASTASSPAPEENA---------PSEGQRVWGQGQSPRPENSLER 177
Cdd:PHA03307  180 EETARAPSSPPAEPPPSTPPAAASPRPPRRSSPISASASSPAPAPGRSAaddagasssDSSSSESSGCGWGPENECPLPR 259

                         170       180       190       200       210
                  ....*....|....*....|....*....|....*....|....*....|....*
gi 749385058  178 EEMGPVPAHTDAFQDWGPGSMAHVSVVPVSSEGTPSREPVASGSWTPKAEEPIHA 232
Cdd:PHA03307  260 PAPITLPTRIWEASGWNGPSSRPGPASSSSSPRERSPSPSPSSPGSGPAPSSPRA 314
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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