calponin homology (CH) domain superfamily; CH domains are actin filament (F-actin) binding motifs, which may be present as a single copy or in tandem repeats (which increase binding affinity). They either function as autonomous actin binding motifs or serve a regulatory function. CH domains are found in cytoskeletal and signal transduction proteins, including actin-binding proteins like spectrin, alpha-actinin, dystrophin, utrophin, and fimbrin, as well as proteins essential for regulation of cell shape (cortexillins), and signaling proteins (Vav).

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  27 DPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLF 106
Cdd:cd21283    1 DPQKEAELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMKPVDLF 80

                         90       100
                 ....*....|....*....|....*....
gi 746576343 107 EANDLFESGNMTQ-----------AKTKG 124
Cdd:cd21283   81 EANDLFESGNMTQvqvsllalagmAKTKG 109

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 746576343  195 ISLQMGTNKCASQVGMTAPGTRRHI 219
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  27 DPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLF 106
Cdd:cd21283    1 DPQKEAELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMKPVDLF 80

                         90       100
                 ....*....|....*....|....*....
gi 746576343 107 EANDLFESGNMTQ-----------AKTKG 124
Cdd:cd21283   81 EANDLFESGNMTQvqvsllalagmAKTKG 109

Calponin homology (CH) domain; The CH domain is found in both cytoskeletal proteins and signal transduction proteins. The CH domain is involved in actin binding in some members of the family. However in calponins there is evidence that the CH domain is not involved in its actin binding activity. Most member proteins have from two to four copies of the CH domain, however some proteins such as calponin have only a single copy.

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343   31 EAELRTWIEGLTGLSIGP----DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIK-AMVSYGMNPVDL 105
Cdd:pfam00307   4 EKELLRWINSHLAEYGPGvrvtNFTTDLRDGLALCALLNKLAPGLVDKKKLNKSEFDKLENINLALDvAEKKLGVPKVLI 83

                          90
                  ....*....|..
gi 746576343  106 fEANDLFESGNM 117
Cdd:pfam00307  84 -EPEDLVEGDNK 94

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 746576343  155 IGLQMGTNKCASQSGMTAYGTRRHL 179
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 746576343  234 MSLQMGYTQGANQSGQV-FGLGRQI 257
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTaFGAVRHI 25

calponin homology (CH) domain found in calponin-2; Calponin-2 (CNN2), also called neutral calponin, or smooth muscle calponin H2, is an actin cytoskeleton-associated regulatory protein that inhibits the activity of myosin-ATPase and cytoskeleton dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  27 DPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLF 106
Cdd:cd21283    1 DPQKEAELRTWIEGLTGRSIGPDFQKGLKDGVILCELMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMKPVDLF 80

                         90       100
                 ....*....|....*....|....*....
gi 746576343 107 EANDLFESGNMTQ-----------AKTKG 124
Cdd:cd21283   81 EANDLFESGNMTQvqvsllalagmAKTKG 109

calponin homology (CH) domain found in calponin-3; Calponin-3 (CNN3), also called acidic isoform calponin, is an F-actin-binding protein that is expressed in the brain and has been shown to control dendritic spine morphology, density, and plasticity by regulating actin cytoskeletal reorganization and dynamics. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  25 KYDPQKEAELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVD 104
Cdd:cd21284    1 KYDPQKEEELRNWIEEVTGMSIGENFQKGLKDGVILCELINKLQPGSIRKINESKLNWHQLENIGNFIKAIQAYGMKPHD 80

                         90       100       110
                 ....*....|....*....|....*....|.
gi 746576343 105 LFEANDLFESGNMTQ-----------AKTKG 124
Cdd:cd21284   81 IFEANDLFENGNMTQvqttllalaglAKTKG 111

calponin homology (CH) domain found in Drosophila melanogaster muscle-specific protein 20 (dMP20) and similar domains; This subfamily contains Drosophila melanogaster muscle-specific protein 20 (dMP20), Echinococcus granulosus myophilin, Dictyostelium discoideum Rac guanine nucleotide exchange factor B (also called Trix), and similar proteins. dMP20 is present only in the synchronous muscles of D. melanogaster. It may be involved in the system linking the nerve impulse with the contraction or the relaxation process. Trix is involved in the regulation of the late steps of the endocytic pathway. dMP20 contains a single copy of the CH domain, while Trix (triple CH-domain array exchange factor) contains three, two type 3 CH domains which are included in this model, and one type 1 CH domain that is not included in this subfamily, but is part of the superfamily. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  25 KYDPQKEAELRTWIEGLTGLSI--GPDFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNP 102
Cdd:cd21207    1 KRDPALEAEALDWIEAVTGEKLddGKDYEDVLKDGVILCKLINILKPGSVKKINTSKMAFKLMENIENFLTACKGYGVPK 80

                         90
                 ....*....|....*..
gi 746576343 103 VDLFEANDLFESGNMTQ 119
Cdd:cd21207   81 TDLFQTVDLYEKKNIPQ 97

calponin homology (CH) domain found in LIM domain only protein 7 and similar proteins; This family includes LIM domain only protein 7 (LMO-7) and LIM and calponin homology domains-containing protein 1 (LIMCH1), and similar proteins. LMO-7, also called F-box only protein 20, or LOMP, is a transcription regulator for expression of many Emery-Dreifuss muscular dystrophy (EDMD)-relevant genes. It binds to alpha-actinin and AF6/afadin at adherens junctions for epithelial cell-cell adhesion. LIMCH1 acts as an actin stress fiber-associated protein that activates the non-muscle myosin IIa complex by promoting the phosphorylation of its regulatory subunit MRLC/MYL9. It positively regulates actin stress fiber assembly and stabilizes focal adhesions, and therefore negatively regulates cell spreading and cell migration. Members of this family contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  31 EAELRTWIEGLTGLSIGP-DFQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQLENLSNFIKAMVSYGMNPVDLFEAN 109
Cdd:cd21208    2 LKEARTWIEAVTGKKFPSdDFRESLEDGILLCELINAIKPGSIKKINRLPTPIAGLDNLNLFLKACEDLGLKDSQLFDPT 81

                 ....*..
gi 746576343 110 DLFESGN 116
Cdd:cd21208   82 DLQDLSN 88

Calponin [Cytoskeleton];

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  19 KNRllSKYDPQKEAELRTWIEGLTGLSIGP--DFQKGLKDGTILCTLMNKLQPGSVpKINRSMQNWHQLENLSNFIKAMV 96
Cdd:COG5199    5 KNR--CPGMDKQQKEVTLWIETVLGEKFEPpgDLLSLLKDGVRLCRILNEASPLDI-KYKESKMPFVQMENISSFINGLK 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  97 SYGMNPVDLFEANDLFESGNMTQ-----------AKTKGLQSGVDIGVKYSEKQERNFD-DATMKAGQCVIGLQMGTNKC 164
Cdd:COG5199   82 KLRVPEYELFQTNDLFEAKDLRQvviclyslsryAQKERMFSGPFLGPHLATKKPRVFSsQEVLDRSKGAIHLQYGYSDL 161

                        170
                 ....*....|....*.
gi 746576343 165 ASQSG-MTAYGTRRHL 179
Cdd:COG5199  162 SEQSTeKGASNVRRDL 177

Calponin homology domain; Actin binding domains present in duplicate at the N-termini of spectrin-like proteins (including dystrophin, alpha-actinin). These domains cross-link actin filaments into bundles and networks. A calponin homology domain is predicted in yeasst Cdc24p.

                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343    33 ELRTWIEGLTGLSIGP---DFQKGLKDGTILCTLMNKLQPGSVPK--INRSMQNWHQLENLSNFIKAMVSYGMNPVdLFE 107
Cdd:smart00033   2 TLLRWVNSLLAEYDKPpvtNFSSDLKDGVALCALLNSLSPGLVDKkkVAASLSRFKKIENINLALSFAEKLGGKVV-LFE 80

                           90
                   ....*....|...
gi 746576343   108 ANDLFESGNMTQA 120
Cdd:smart00033  81 PEDLVEGPKLILG 93

calponin homology (CH) domain found in transgelin-2; Transgelin-2, also called epididymis tissue protein Li 7e, or SM22-alpha homolog, acts as an actin-binding protein that induces actin gelation and regulates the actin cytoskeleton. It may participate in the development and progression of multiple cancers. It contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  25 KYDPQKEAELRTWIEGLTGLSIGPD------FQKGLKDGTILCTLMNKLQPGS---VPKINRSMQNWHQLENLSNFIKAM 95
Cdd:cd21280    4 QYDADLEQILIQWITAQCGKQVGRPqpgrenFQNWLKDGTVLCHLINSLYPKGqapVKKIQASTMAFKQMEQISQFLQAA 83

                         90       100
                 ....*....|....*....|..
gi 746576343  96 VSYGMNPVDLFEANDLFESGNM 117
Cdd:cd21280   84 ERYGINTTDIFQTVDLWEGKNM 105

calponin homology (CH) domain found in Arabidopsis thaliana Kinesin-like KIN-14 protein family; Kinesins are microtubule-dependent molecular motors that play important roles in intracellular transport and in cell division. This family includes a group of kinesin-like proteins belonging to KIN-14 protein family. They all contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  33 ELRTWIEGLTGLSIGPD-----FQKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQ--------LENLSNFIKAMVSYG 99
Cdd:cd21203    4 EAAEWIQNVLGVLVLPDpseeeFRLCLRDGVVLCKLLNKLQPGAVPKVVESPDDPDGaagsafqyFENVRNFLVAIEEMG 83

                         90
                 ....*....|....*.
gi 746576343 100 MnpvDLFEANDLFESG 115
Cdd:cd21203   84 L---PTFEASDLEQGG 96

calponin homology (CH) domain found in VAV proteins; VAV proteins function both as cytoplasmic guanine nucleotide exchange factors (GEFs) for Rho GTPases and as scaffold proteins, and they play important roles in cell signaling by coupling cell surface receptors to various effector functions. They play key roles in processes that require cytoskeletal reorganization including immune synapse formation, phagocytosis, cell spreading, and platelet aggregation, among others. Vertebrates have three VAV proteins (VAV1, VAV2, and VAV3). VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. This model corresponds to the CH domain, an actin-binding domain which is present as a single copy in VAV proteins.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 746576343  49 DFQKGLKDGTILCTLMNKLQPGSVPKI----NRSMQNWHQLENLSNFIKAMVS-YGMNPVDLFEANDLFESGNM 117
Cdd:cd21201   31 DLAQALRDGVLLCQLLNRLSPGSVDDReinlRPQMSQFLCLKNIRTFLQACRTvFGLRSADLFEPEDLYDVTNF 104

calponin homology (CH) domain found in transgelin; Transgelin, also called 22 kDa actin-binding protein, protein WS3-10, or smooth muscle protein 22-alpha (SM22-alpha), acts as an actin cross-linking/gelling protein that may be involved in calcium interactions and in regulating contractile properties of the cell. It may also contribute to replicative senescence. Transgelin contains a single copy of the CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  27 DPQKEAELRTWIEGLTGLSIG-PD-----FQKGLKDGTILCTLMNKL-----QPGSVPKINRSMQnWHQLENLSNFIKAM 95
Cdd:cd21279    1 DEELEERLVEWIVVQCGPDVGrPDrgrlgFQVWLKNGVVLSKLVNSLypdgsKPVKIPDNPPSMV-FKQMEQVAQFLKAA 79

                         90       100
                 ....*....|....*....|..
gi 746576343  96 VSYGMNPVDLFEANDLFESGNM 117
Cdd:cd21279   80 EDYGVVKTDMFQTVDLYEGKDM 101

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 746576343  155 IGLQMGTNKCASQSGMTAYGTRRHL 179
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTAFGAVRHI 25

calponin homology (CH) domain found in the Pak Interactive eXchange factor family; Pak Interactive eXchange factor (PIX) proteins are Rho guanine nucleotide exchange factors (GEFs), which activate small GTPases by exchanging bound GDP for free GTP. They act as GEFs for both Cdc42 and Rac1, and have been implicated in cell motility, adhesion, neurite outgrowth, and cell polarity. Vertebrates contain two proteins from the PIX family, alpha-PIX and beta-PIX. Alpha-PIX, also called Rho guanine nucleotide exchange factor 6 (ARHGEF6), is localized in dendritic spines where it regulates spine morphogenesis. It controls dendritic length and spine density in the hippocampus. Mutations in the ARHGEF6 gene cause X-linked intellectual disability in humans. Beta-PIX, also called Rho guanine nucleotide exchange factor 7 (ARHGEF7), plays important roles in regulating neuroendocrine exocytosis, focal adhesion maturation, cell migration, synaptic vesicle localization, and insulin secretion. Both alpha-PIX and beta-PIX contain a single copy of the CH domain at the N-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 746576343  51 QKGLKDGTILCTLMNKLQPGSVPKINRSMQNWHQ-LENLSNFIKAMVSYGMNPVDLFEANDLFESGN 116
Cdd:cd21202   31 SESLKNGVVLCRLVNRLKPGTVEKIYDEPTTEEEcLYNFESFLKACQELGILAEEIFDPNDLYSGGN 97

calponin homology (CH) domain found in the growth arrest-specific protein 2 family; The growth arrest-specific protein 2 (GAS-2) family includes GAS-2, and GAS-2 like proteins, GAS2L1-3. GAS-2 may play a role in apoptosis by acting as a cell death substrate for caspases. GAS2L1 (also called GAS2-related protein on chromosome 22 or growth arrest-specific protein 2-like 1) and GAS2L2 (also called GAS2-related protein on chromosome 17 or growth arrest-specific protein 2-like 2) may be involved in the cross-linking of microtubules and microfilaments. GAS2L3, also called GAS2-like protein 3, is a cytoskeletal linker protein that may promote and stabilize the formation of the actin and microtubule network. Members of this family contain a single copy of the CH domain at the N-terminal region. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  27 DPQKEaELRTWIEGLTGLSIGPD-FQKGLKDGTILCTLMNKLQ-----------PGSVPKINRSMQN-------WHQLEN 87
Cdd:cd21204    5 LPMKE-DLAEWLNDLLGDDLTPDnFLDELRNGVVLCQLAQKIQeaaekareagkKNGPPPSYKLKCNenakpgsFFARDN 83

                         90       100
                 ....*....|....*....|....*.
gi 746576343  88 LSNFIKAMVSYGMNPVDLFEANDLFE 113
Cdd:cd21204   84 VANFLRWCRKLGVDEVLLFESEDLVL 109

calponin homology (CH) domain found in leucine-rich repeat and calponin homology domain-containing protein 4; Leucine-rich repeat and calponin homology domain-containing protein 4 (LRCH4), also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. LRCH4 contains a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  32 AELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKIN------RSMQNWHQLENLSNFIKAMVSYGMNPVDL 105
Cdd:cd21273    7 AQLRKTLESRLKVTLPEDLAEALSNGAVLCQLANQLRPRSVSIIHvpspavPKLSKAKCRKNVENFIEACRKMGVPEVDL 86

                         90
                 ....*....|
gi 746576343 106 FEANDLFESG 115
Cdd:cd21273   87 CSPSDVLLQG 96

first calponin homology (CH) domain found in the plastin/fimbrin family; This family includes plastin and fimbrin. Plastin has three isoforms, plastin-1, -2, and -3, which are all actin-bundling proteins. Plastin-1, also called intestine-specific plastin, or I-plastin, is an actin-bundling protein in the absence of calcium. Plastin-2, also called L-plastin, LC64P, or lymphocyte cytosolic protein 1 (LCP-1), plays a role in the activation of T-cells in response to costimulation through TCR/CD3 and CD2 or CD28. It modulates the cell surface expression of IL2RA/CD25 and CD69. Plastin-3, also called T-plastin, is found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. It may play a role in the regulation of bone development. Fimbrin has been found in plants and fungi. Arabidopsis thaliana fimbrin (AtFIM) includes fimbrin-1, -2, -3, -4, and -5; they cross-link actin filaments (F-actin) in a calcium independent manner. They stabilize and prevent F-actin depolymerization mediated by profilin. They act as key regulators of actin cytoarchitecture, probably involved in cell cycle, cell division, cell elongation and cytoplasmic tractus. AtFIM5 is an actin bundling factor that is required for pollen germination and pollen tube growth. Fungal fimbrin binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Members of this family contain four copies of the CH domain. This model corresponds to the first CH domain. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 746576343  54 LKDGTILCTLMNKLQPGSVP--KINRSMQN--WHQLENLSNFIKAMVSYGMNPVDLfEANDL 111
Cdd:cd21217   37 LRDGVLLCKLINKIVPGTIDerKLNKKKPKniFEATENLNLALNAAKKIGCKVVNI-GPQDI 97

calponin homology (CH) domain found in the leucine-rich repeat and calponin homology domain-containing protein family; The leucine-rich repeat and calponin homology domain-containing protein (LRCH) family includes LRCH1-4. LRCH1, also called calponin homology domain-containing protein 1, or neuronal protein 81 (NP81), acts as a negative regulator of GTPase Cdc42 by sequestering Cdc42-guanine exchange factor DOCK8. LRCH2 may play a role in the organization of the cytoskeleton. LRCH3 is part of the DISP complex and may regulate the association of septins with actin and thereby regulate the actin cytoskeleton. LRCH4, also called leucine-rich repeat neuronal protein 4, or leucine-rich neuronal protein, acts as a novel Toll-like receptor (TLR) accessory protein that regulates the innate immune response. Members of this family contain a single copy of the CH domain at the C-terminus. CH domains are actin filament (F-actin) binding motifs.

                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  33 ELRTWIEGLTGLSIGPDFQKGLKDGTILCTLMNKLQPGSVPKINR--------SMQNwhQLENLSNFIKAMVSYGMNPVD 104
Cdd:cd21205    5 QLRKSIESRLKVTLPDDLGEALMDGVVLCHLANHVRPRSVPSIHVpspavpklSMAK--CRRNVENFLEACRKLGVPEER 82

                 ....*....
gi 746576343 105 LFEANDLFE 113
Cdd:cd21205   83 LCSPGDILE 91

calponin homology (CH) domain found in VAV2 protein and similar proteins; VAV2 is widely expressed and functions as a guanine nucleotide exchange factor (GEF) for RhoA, RhoB and RhoG and also activates Rac1 and Cdc42. It is implicated in many cellular and physiological functions including blood pressure control, eye development, neurite outgrowth and branching, EGFR endocytosis and degradation, and cell cluster morphology, among others. It has been reported to associate with Nek3. VAV proteins contain several domains that enable their function: N-terminal calponin homology (CH), acidic, RhoGEF (also called Dbl-homologous or DH), Pleckstrin Homology (PH), C1 (zinc finger), SH2, and two SH3 domains. The model corresponds to CH domain, an actin-binding domain which is present as a single copy in VAV2 protein.

                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343  49 DFQKGLKDGTILCTLMNKLQPGSV--PKIN--RSMQNWHQLENLSNFIKAMV-SYGMNPVDLFEANDLFE 113
Cdd:cd21263   31 DLAQALRDGVLLCQLLHNLSPGSIdlKDINfrPQMSQFLCLKNIRTFLKVCHdKFGLRNSELFDPFDLFD 100

Calponin family repeat;

                          10        20
                  ....*....|....*....|....*
gi 746576343  234 MSLQMGYTQGANQSGQV-FGLGRQI 257
Cdd:pfam00402   1 IGLQMGTNKGASQSGMTaFGAVRHI 25

Protein involved in regulation of cellular morphogenesis/cytokinesis [Cell division and chromosome partitioning / Signal transduction mechanisms];

                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 746576343   33 ELRTWIEGLTGLSIG-PDFQKGLKDGTILCTLMNKLQPGSVPKI--NRSMQNWHQlENLSNFIKAMVSYGMNPVDLFEAN 109
Cdd:COG5261    48 EAKIWIEEVIEEALPeLCFEDSLRNGVFLAKLTQRFNPDLTTVIfpADKLQFRHT-DNINAFLDLIEHVGLPESFHFELQ 126

                          90
                  ....*....|
gi 746576343  110 DLFESGNMTQ 119
Cdd:COG5261   127 DLYEKKNIPK 136