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Conserved domains on  [gi|744066867|ref|NP_001290404|]
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T-box transcription factor TBX22 isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
T-box super family cl00145
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 1-163 8.43e-128

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


The actual alignment was detected with superfamily member cd20200:

Pssm-ID: 469628  Cd Length: 194  Bit Score: 366.17  E-value: 8.43e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20200   32 MFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGNTDHSCITPRLYVHPDSPCSGETWMRQIISFDRVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20200  112 LTNNEMDDKGHIILQSMHKYKPRVHVILQDSRFDLSQIQSLPAEGVKTFSFPETEFTTVTAYQNQQITKLKIDRNPFAKG 191


                 ...
gi 744066867 161 FRD 163
Cdd:cd20200  192 FRD 194
 
Name Accession Description Interval E-value
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 1-163 8.43e-128

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 366.17  E-value: 8.43e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20200   32 MFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGNTDHSCITPRLYVHPDSPCSGETWMRQIISFDRVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20200  112 LTNNEMDDKGHIILQSMHKYKPRVHVILQDSRFDLSQIQSLPAEGVKTFSFPETEFTTVTAYQNQQITKLKIDRNPFAKG 191


                 ...
gi 744066867 161 FRD 163
Cdd:cd20200  192 FRD 194
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 1-163 7.43e-92

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 274.05  E-value: 7.43e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867    1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:pfam00907  28 MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEP-HSPPRVYIHPDSPATGSHWMKQPVSFDKLK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDlsqiqSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:pfam00907 105 LTNNKEDKNGHIILNSMHKYQPRLHIVRVGGDEP-----SLPEENVKTFVFPETEFIAVTAYQNEEITQLKIDNNPFAKG 179


                  ...
gi 744066867  161 FRD 163
Cdd:pfam00907 180 FRD 182
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
1-168 2.95e-81

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 247.18  E-value: 2.95e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867     1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:smart00425  30 MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKF--NNGKWVVAGKAEP-HMPSRVYVHPDSPATGAHWMKQPVSFDKVK 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867    81 LTNNEMDDKGH--IILQSMHKYKPRVHVIEqgssvdLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFA 158
Cdd:smart00425 107 LTNNQSDKNGHlqIILNSMHKYQPRLHIVE------VDDISKEILSQFKTFVFPETQFIAVTAYQNQKITKLKIDNNPFA 180

                          170
                   ....*....|
gi 744066867   159 KGFRDTGRNR 168
Cdd:smart00425 181 KGFRDQGRRR 190
 
Name Accession Description Interval E-value
T-box_TBX22-like cd20200
DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a ...
 1-163 8.43e-128

DNA-binding domain of T-box transcription factor 22 and related T-box proteins; TBX22 is a transcriptional regulator involved in developmental processes. Mutations in the T-Box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome). TBX22 mutation is also associated with cleft lip and palate, and tooth agenesis. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410326  Cd Length: 194  Bit Score: 366.17  E-value: 8.43e-128
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20200   32 MFPSVRVKVKGLDPLKQYYIAMDVVPVDSKRYRYVYHSSQWMVAGNTDHSCITPRLYVHPDSPCSGETWMRQIISFDRVK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20200  112 LTNNEMDDKGHIILQSMHKYKPRVHVILQDSRFDLSQIQSLPAEGVKTFSFPETEFTTVTAYQNQQITKLKIDRNPFAKG 191


                 ...
gi 744066867 161 FRD 163
Cdd:cd20200  192 FRD 194
T-box_TBX15_18_22-like cd20191
DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; ...
 1-163 3.78e-113

DNA-binding domain of T-box transcription factor 15, 18 and 22, and related T-box proteins; This subfamily includes the transcriptional regulators TBX15, TBX18 and TBX22 which are involved in various developmental processes. TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes; it also plays a role in the differentiation of brown and brite adipocytes. TBX18 is involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels; it is important for the development of the head portion of the sino atrial node (SAN). Mutations in the T-box transcription factor gene TBX22 are found in X-linked Cleft Palate with or without Ankyloglossia syndrome (CPX syndrome), and associated with cleft lip and palate, and tooth agenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410317  Cd Length: 194  Bit Score: 328.77  E-value: 3.78e-113
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIiPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20191   32 MFPAIRVKVSGLDPHAQYIVAMDIVPVDNKRYRYVYHSSKWMVAGNADAPVP-PRVYIHPDSPASGETWMRQVVSFDKLK 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQI-QSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20191  111 LTNNEMDDQGHIILHSMHKYQPRVHVIRKDSSTDLSPKkPVPPGEGVKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAK 190


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20191  191 GFRD 194
T-box pfam00907
T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box ...
 1-163 7.43e-92

T-box; The T-box encodes a 180 amino acid domain that binds to DNA. Genes encoding T-box proteins are found in a wide range of animals, but not in other kingdoms such as plants. Family members are all thought to bind to the DNA consensus sequence TCACACCT. they are found exclusively in the nucleus, and perform DNA-binding and transcriptional activation/repression roles. They are generally required for development of the specific tissues they are expressed in, and mutations in T-box genes are implicated in human conditions such as DiGeorge syndrome and X-linked cleft palate, which feature malformations.


Pssm-ID: 459990  Cd Length: 182  Bit Score: 274.05  E-value: 7.43e-92
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867    1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:pfam00907  28 MFPTLKVSVSGLDPNAKYSVLLDIVPVDDKRYKF--HNGKWVVAGKAEP-HSPPRVYIHPDSPATGSHWMKQPVSFDKLK 104

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDlsqiqSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:pfam00907 105 LTNNKEDKNGHIILNSMHKYQPRLHIVRVGGDEP-----SLPEENVKTFVFPETEFIAVTAYQNEEITQLKIDNNPFAKG 179


                  ...
gi 744066867  161 FRD 163
Cdd:pfam00907 180 FRD 182
T-box_TBX18_like cd20199
DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as ...
 1-163 1.08e-90

DNA-binding domain of T-box transcription factor 18 and related T-box proteins; TBX18 acts as a transcription repressor involved in the developmental processes of a variety of tissues and organs, including the ureter, vertebral column. epicardium and coronary vessels. TBX18 is important for the development of the head portion of the sino atrial node (SAN); SAN is the pacemaker region of the heart that initiates each heartbeat. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410325  Cd Length: 195  Bit Score: 271.53  E-value: 1.08e-90
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20199   33 MFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS-PVPPRVYIHPDSPASGETWMRQVISFDKLK 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPT-EGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20199  112 LTNNELDDQGHIILHSMHKYQPRVHVIRKECGEELSPVKPIPSgEGVKAFSFPETVFTTVTAYQNQQITRLKIDRNPFAK 191


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20199  192 GFRD 195
T-box_TBX15-like cd20198
DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also ...
 1-163 1.94e-84

DNA-binding domain of T-box transcription factor 15 and related T-box proteins; TBX15 (also known as TBX14) plays an important role in the development of the skeleton of the limb, vertebral column and head, possibly through its control of the number of mesenchymal precursor cells and chondrocytes. TBX15 also plays a role in the differentiation of brown and brite adipocytes. This subgroup belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410324  Cd Length: 198  Bit Score: 255.81  E-value: 1.94e-84
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20198   36 MFPAMRVKITGLDPHQQYYIAMDIVPVDNKRYRYVYHSSKWMVAGNADS-PVPPRVYIHPDSLASGDTWMRQVVSFDKLK 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPT-EGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20198  115 LTNNELDDQGHIILHSMHKYQPRVHVIRKDFSSDLSPTKPVPTgDGVKTFSFPETVFTTVTAYQNQQITRLKIDRNPFAK 194


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20198  195 GFRD 198
TBOX smart00425
Domain first found in the mice T locus (Brachyury) protein;
1-168 2.95e-81

Domain first found in the mice T locus (Brachyury) protein;


Pssm-ID: 214656  Cd Length: 190  Bit Score: 247.18  E-value: 2.95e-81
                           10        20        30        40        50        60        70        80
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867     1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHlCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:smart00425  30 MFPTLKYKVSGLDPNALYSVLMDLVPVDDKRYKF--NNGKWVVAGKAEP-HMPSRVYVHPDSPATGAHWMKQPVSFDKVK 106

                           90       100       110       120       130       140       150       160
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867    81 LTNNEMDDKGH--IILQSMHKYKPRVHVIEqgssvdLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFA 158
Cdd:smart00425 107 LTNNQSDKNGHlqIILNSMHKYQPRLHIVE------VDDISKEILSQFKTFVFPETQFIAVTAYQNQKITKLKIDNNPFA 180

                          170
                   ....*....|
gi 744066867   159 KGFRDTGRNR 168
Cdd:smart00425 181 KGFRDQGRRR 190
T-box_TBX20-like cd20193
DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a ...
 1-164 2.75e-80

DNA-binding domain of T-box transcription factor 20 and related T-box proteins; TBX20 is a T-box transcriptional factor which functions in embryonic development and its deficiency is associated with congenital heart disease. It acts both as a transcriptional activator and a repressor required for cardiac development, and has key roles in maintaining the functional and structural phenotypes in the adult heart. The TBX20-cardiac transcription factor CASZ1 protein complex is protective against dilated cardiomyopathy and is essential for maintaining cardiac homeostasis. TBX20 has also been shown to regulate angiogenesis through the PROK2-PROKR1 (prokineticin receptor 1) pathway and is involved in both, pathological and developmental, angiogenesis. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410319  Cd Length: 190  Bit Score: 245.03  E-value: 2.75e-80
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLcIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20193   30 MFPTVRVSFSGVDPDAKYIVLMDIVPVDNKRYRYAYHRSSWLVAGKADPP-LPARLYVHPDSPFTGEQLLKQMVSFEKVK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQgsSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20193  109 LTNNELDKHGHIILNSMHKYQPRVHIVKK--KDHTASLVNLKSEEFRTFIFPETVFTAVTAYQNQLITKLKIDSNPFAKG 186


                 ....
gi 744066867 161 FRDT 164
Cdd:cd20193  187 FRDS 190
T-box-like cd20682
T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that ...
 1-163 2.13e-76

T-box DNA-binding domain; uncharacterized subfamily; The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410333  Cd Length: 191  Bit Score: 234.98  E-value: 2.13e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLCIIPRfYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20682   30 MFPALKVKLTGLDPDKLYIVWVDIVPVDSNRYRYVYHSSKWVVAGSGDVLPPANR-YIHPDSPASGKYWMSQIVSFDKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNN-EMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQIQSLPTEgVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20682  109 LTNNkEPKQKGQISLHSMHKYQPRIHIQPVEDDGRNVEKAINSSK-ALSFEFPETSFITVTAYQNQQITKLKIASNPFAK 187


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20682  188 GFRD 191
T-box_TBX1_10-like cd20187
DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; ...
 1-163 7.54e-76

DNA-binding domain of T-box transcription factor 1 and 10, and related T-box proteifactors; This subfamily includes TBX1 and TBX10. TBX1 is a T-box transcription factor which plays an important role in heart development and has been implicated in DiGeorge or 22q11.2 deletion syndrome. This syndrome is associated with various types of cardiac outflow tract (OFT) and vascular defects. Wnt5a is regulated by TBX1 in the second heart field (SHF). TBX1 is required to maintain the integrity of extracellular matrix-cell interactions in the SHF and this interaction is critical for cardiac (OFT) development. TBX10 is a putative T-box transcription factor. Diseases associated with TBX10 include Isolated Cleft Lip and Cleft Lip/cleft lip with or without cleft palate. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410313  Cd Length: 189  Bit Score: 233.47  E-value: 7.54e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVYHSSQWMVAGNTDHLcIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20187   31 MFPTFQVKIFGMDPMADYMLMMDFVPVDDKRYRYAFHSSSWLVAGKADPA-MPGRIHVHPDSPAKGAQWMKQIVSFDKLK 109

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVI-EQGSSVDLSQiqslPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20187  110 LTNNLLDDNGHIILNSMHRYQPRFHVVyVDPRKDSENS----AEENFKTFIFPETKFTAVTAYQNHRITQLKIASNPFAK 185


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20187  186 GFRD 189
T-box_TBX4_5-like cd20189
DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This ...
 1-163 1.02e-69

DNA-binding domain of T-box transcription factor 4 and 5, and related T-box proteins; This subfamily includes the T-box transcription factors TBX4 and TBX5 which play important roles in vertebrate limb and heart development, and in lung and trachea development. TBX4 is needed for normal skeletal and muscular hindlimb development and is involved in super-enhancer-driven transcriptional programs underlying features specific to lung fibroblasts. TBX5 plays a role in regulating cardiac conduction system function, and in coordinating forelimb muscle pattern. Mutations in human TBX5 and TBX4 are associated with Holt-Oram syndrome and Small Patella syndrome, respectively. Both syndromes are characterized by limb defects in addition to other abnormalities. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410315  Cd Length: 185  Bit Score: 217.68  E-value: 1.02e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTD-HlciIP-RFYVHPDSPCSGETWMRQIISFDR 78
Cdd:cd20189   30 MFPSIKVKVTGLNPKTKYILLMDIVPADDHRYKF--HDSEWVVAGKAEpA---MPgRLYVHPDSPATGAHWMRQLVSFQK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  79 MKLTNNEMDDKGHIILQSMHKYKPRVHVIEqgssVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFA 158
Cdd:cd20189  105 LKLTNNHLDQFGHIILNSMHKYQPRIHIVQ----ADDNNAFGSKNTAFSTHVFPETAFIAVTAYQNHQITQLKIENNPFA 180


                 ....*
gi 744066867 159 KGFRD 163
Cdd:cd20189  181 KGFRG 185
T-box_TBX2_3-like cd20188
DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This ...
 1-163 9.17e-69

DNA-binding domain of T-box transcription factor 2 and 3, and related T-box proteins; This subfamily includes the T-box transcription factors TBX2 and TBX3 and similar proteins. TBX2 is an oncogenic transcription factor implicated in developmental processes, including coordinating cell fate, patterning and morphogenesis of a wide range of tissues and organs. It is overexpressed in several cancers, including melanoma and breast, and plays a key role during cardiac development. TBX2 is a negative regulator of promyelocytic leukemia protein (PML) function in cellular senescence, and it interacts with HP1 to recruit a repression complex to EGR1-responsive promoters to drive the proliferation of breast cancer cells. TBX3 has also been implicated in oncogenesis in breast cancer and melanoma. The tbx3 gene is downregulated by PML. TBX3 directly represses TBX2 under the control of the PRC2 complex in skeletal muscle and rhabdomyosarcoma. Also included in this family is the Drosophila melanogaster optomotor-blind protein (Omb, also known as lethal(1)optomotor-blind, or L(1)omb, or protein bifid) which controls many developmental processes such as wing, eye, and abdominal tergites and optic lobes, and induces epithelial cell migration and extrusion in vivo. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410314  Cd Length: 185  Bit Score: 215.37  E-value: 9.17e-69
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSkrYRYVYHSSQWMVAGNTDHLcIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20188   32 MFPPFKVRVSGLDKKAKYILLMDIVAADD--CRYKFHNSRWMVAGKADPE-MPKRMYIHPDSPSTGEQWMQKVVSFHKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVieqgssVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20188  109 LTNNISDKHGFTILNSMHKYQPRFHI------VRANDILKLPYSTFRTYVFKETEFIAVTAYQNEKITQLKIDNNPFAKG 182


                 ...
gi 744066867 161 FRD 163
Cdd:cd20188  183 FRD 185
T-box_Drosocross-like cd20681
DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross ...
 1-163 2.14e-65

DNA-binding domain of Drosophila Dorsocross and related T-box proteins; Drosophila Dorsocross (Doc) includes three Dorsocross paralogs, Doc1-3. These are key cardiogenic T-box transcription factors during specification and differentiation of heart cells. Drosophila Doc also functions in caudal visceral mesoderm development, and modulates Notch signaling in the developing Drosophila eye by regulating the expression of Delta in the eye imaginal discs. Doc also functions in the morphogenesis of epithelial tissues: in Drosophila, which possesses a single extraembryonic (EE) membrane, it is essential for EE epithelia tissue maintenance while in Tribolium castaneum, which has 2 EE membranes, Doc plays a major role in EE morphogenetic events throughout development without affecting EE tissue specificity or maintenance. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410332  Cd Length: 186  Bit Score: 206.41  E-value: 2.14e-65
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVyHSSQWMVAGNTDHLCIIP-RFYVHPDSPCSGETWMRQIISFDRM 79
Cdd:cd20681   30 MFPSLRLSVSGLEPDARYCVLLEMVLASDCRFKYS-GNGGWVPAGGAEPQPPLPrRIYIHPDSPATGDHWMSQPISFSKV 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  80 KLTNNEMDDKGHIILQSMHKYKPRVHVIEqgsSVDLSQIQSLPTegvKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20681  109 KLTNNTLDPQGNIVLTSMHKYQPRIHIVR---CSDTLALPWAPT---ASFTFPETEFIAVTAYQNERITKLKIDNNPFAK 182


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20681  183 GFRE 186
T-box cd00182
DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient ...
 1-155 1.40e-63

DNA-binding domain of the T-box transcription factor family; The T-box family is an ancient family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the family is Brachyury (also known as TBXT, or T). Members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns. The T-box factors in Caenorhabditis elegans have evolved very differently than those in other organisms; its genome contains 22 T-box genes which encode factors which are diverse in DNA-binding specificity, function and sequence, and only 3 of these factors fall into the conserved T-box subfamilies.


Pssm-ID: 410312  Cd Length: 176  Bit Score: 201.67  E-value: 1.40e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd00182   30 MFPTLEYSVSGLDPNKLYSVSLHFERVDNKRYKF--NNGKWVPSGKAEPPPEPSRIYVHPDGPQTGSFWMKKGVSFDKVK 107

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 744066867  81 LTNN-EMDDKGHIILQSMHKYKPRVHVIEQGSsvdlsqiQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERN 155
Cdd:cd00182  108 ITNNkEDKKEGHILLHSMHKYIPVLTIYEVDD-------NGLLSKLVKEFRFPETEFIAVTAYQNDEITQLKIDNN 176
T-box_TBX6_VegT-like cd20190
DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This ...
 1-163 1.09e-59

DNA-binding domain of T-box transcription factor 6, VegT and related T-box proteins; This subfamily includes the transcriptional regulators TBX6 and VegT. TBX6 plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos through effects on nodal cilia and perinodal signaling. VegT (also known as Antipodean, Brat and Xombi) is required in early Xenopus embryos for the formation of both the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved 1DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410316  Cd Length: 183  Bit Score: 191.63  E-value: 1.09e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTD-HLciiP-RFYVHPDSPCSGETWMRQIISFDR 78
Cdd:cd20190   30 MFPACKVSVTGLDPEAKYLFLLDVVPVDNARYKW--NKRRWEPSGKAEpHL---PdRVYIHPDSPAPGAHWMRQPISFHK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  79 MKLTNNEMDDKGHIILQSMHKYKPRVHVIEQgssvdlSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFA 158
Cdd:cd20190  105 LKLTNNTLDPHGHLILHSMHKYQPRIHLVQS------ADLCSQHWGGMASFRFPETTFIAVTAYQNPQITKLKIAANPFA 178


                 ....*
gi 744066867 159 KGFRD 163
Cdd:cd20190  179 KGFRE 183
T-box_VegT-like cd20197
DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, ...
 1-163 9.39e-59

DNA-binding domain of Xenopus VegT and related T-box proteins; VegT, (also known as Antipodean, Brat and Xombi), is a T-box transcription factor required in early Xenopus embryos for the formation of both, the mesoderm and endoderm germ layers. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410323  Cd Length: 183  Bit Score: 189.28  E-value: 9.39e-59
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTD-HLciiP-RFYVHPDSPCSGETWMRQIISFDR 78
Cdd:cd20197   30 MFPQCKIRVSGLLPYAKYVMLVDFVPVDNFRYKW--NKDQWEVAGKAEpQP---PcRTYVHPDSPAPGSHWMKQPISFQK 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  79 MKLTNNEMDDKGHIILQSMHKYKPRVHVIEqgsSVDLSqiqSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFA 158
Cdd:cd20197  105 LKLTNNTLDQHGHIILHSMHRYQPRFHIVQ---ADDLF---NVRWSLFQVFSFPETVFTAVTAYQNEKITKLKIDNNPFA 178


                 ....*
gi 744066867 159 KGFRD 163
Cdd:cd20197  179 KGFRE 183
T-box_TBX6 cd20196
DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a ...
 1-163 1.79e-57

DNA-binding domain of T-box transcription factor 6, and related T-box proteins; TBX6 is a T-box transcription factor which plays an essential role in the fate determination of axial stem to become either neural or mesodermal. It also plays an essential role in the regulation of left/right patterning in mouse embryos, through effects on nodal cilia and perinodal signaling. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410322  Cd Length: 182  Bit Score: 186.23  E-value: 1.79e-57
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDhLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20196   30 MFPQLRVSVSGLDPEARYLLLLDVVPVDGSRYRW--QGNSWEASGKAE-PRLPDRVYIHPDSPATGAHWMRQPISFHRAK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQiqslpteGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20196  107 LTNNTLDPHGHIILHSMHRYQPRVHVVRARDVLSWGG-------GCASFTFPETQFITVTAYQNPKITQLKINSNPFAKG 179


                 ...
gi 744066867 161 FRD 163
Cdd:cd20196  180 FRE 182
T-box_MGA-like cd20195
DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known ...
 1-163 4.98e-56

DNA-binding domain of MAX gene-associated protein and related T-box proteins; MGA (also known as MGAP, MAX dimerization protein, MAD5, MXD5) is a dual-specificity transcription factor that regulates the expression of both, MAX-network and T-box family target genes. MGA functions as a repressor or an activator; it binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence. Its function is activated by heterodimerization with MAX. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410321  Cd Length: 186  Bit Score: 182.25  E-value: 4.98e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDskRYRYVYHSSQWMVAGNTD-HLciIPRFYVHPDSPCSGETWMRQIISFDRM 79
Cdd:cd20195   30 MFPYCRFRISGLDPDRNYILVMDISPVD--NFRYRWNGRWWEPSGKAEpHV--LGRVFIHPESPATGRHWMDQPVSFYKL 105

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  80 KLTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDlsqIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAK 159
Cdd:cd20195  106 KLTNNTLDQEGHIILHSMHRYLPRLHVVPADKEVD---VIQLNGPDVHTFTFPQTEFFAVTAYQNKQITQLKIDYNPFAK 182


                 ....
gi 744066867 160 GFRD 163
Cdd:cd20195  183 GFRE 186
T-box_TBR1_2_21-like cd20194
DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related ...
 1-163 8.09e-56

DNA-binding domain of T-box brain protein 1 and 2, T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. This subfamily includes TBR1 (also known as T-brain-1, or TES-56), which is a neuron-specific transcription factor involved in forebrain development, and TBR2 (also known as Eomesodermin, Eomes, or T-brain-2), which is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410320  Cd Length: 185  Bit Score: 181.91  E-value: 8.09e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20194   31 MFPTLSFNLSGLDPTAHYNVFVDMVLADPNHWKF--QSGKWVPCGKAEGLPQGNRVYVHPDSPNTGAHWMKQEISFSKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNEMDDKGHIILQSMHKYKPRVHVIEQGSSVDLSQiqslptEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20194  109 LTNNKGADQGMIVLNSMHKYQPRIHVIEVGGNGPNEQ------RNLQTHSFPETQFIAVTAYQNTDITQLKIDHNPFAKG 182


                 ...
gi 744066867 161 FRD 163
Cdd:cd20194  183 FRD 185
T-box_TBXT_TBX19-like cd20192
DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related ...
 1-163 9.41e-56

DNA-binding domain of T-box transcription factor T, T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410318  Cd Length: 180  Bit Score: 181.31  E-value: 9.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVyhSSQWMVAGNTDHLcIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20192   30 MFPVLKVSVSGLDPNAMYSVLLDFVQVDNHRWKYV--NGEWVPGGKAEPP-PPSSVYVHPDSPNFGAHWMKGPVSFSKVK 106

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNeMDDKGHIILQSMHKYKPRVHVIEQGSSVdlsqiqslPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPFAKG 160
Cdd:cd20192  107 LTNK-PNGEGQIMLNSLHKYEPRVHIVRVGSNN--------HERLVSTFSFPETQFIAVTAYQNEEITALKIKYNPFAKA 177


                 ...
gi 744066867 161 FRD 163
Cdd:cd20192  178 FLD 180
T-box_TBX21 cd20203
DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also ...
 1-163 8.11e-48

DNA-binding domain of T-box transcription factor 21 and related T-box proteins; TBX21 (also known as T-cell-specific T-box transcription factor T-bet or transcription factor TBLYM) is a lineage-defining transcription factor which directs T helper type 1 (Th1) cell differentiation. It initiates Th1 lineage development from naive T helper precursor cells both by initiating the Th1 genetic programs and by inhibiting the opposing Th2 and Th17 lineage-commitment programs. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410329  Cd Length: 191  Bit Score: 161.28  E-value: 8.11e-48
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20203   31 MFPFLSFNLTGLDPTAHYNVYVDVVLADQHHWRY--QGGKWVQCGKAEGNMPGNRLYVHPDSPNTGAHWMRQEVSFGKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNE---MDDKGHIILQSMHKYKPRVHVIEqgsSVDLSQIQSLPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPF 157
Cdd:cd20203  109 LTNNKgasNNVTQMIVLQSLHKYQPRLHIVE---VKEGETEEAYSSSKTHTFTFPETQFIAVTAYQNAEITQLKIDHNPF 185


                 ....*.
gi 744066867 158 AKGFRD 163
Cdd:cd20203  186 AKGFRD 191
T-box_TBR1 cd20204
DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as ...
 1-163 5.68e-45

DNA-binding domain of T-box brain protein 1 and related T-box proteins; TBR1 (also known as T-brain-1 or TES-56) is a neuron-specific transcription factor of the T-box family and involved in forebrain development. It has been recognized as a high-confidence risk gene for autism spectrum disorders (ASD); it regulates the expression of ASD-related genes that are critical for cortical development. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410330  Cd Length: 191  Bit Score: 154.12  E-value: 5.68e-45
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20204   31 MFPFLSFNISGLDPTAHYNIFVDVILADPNHWRF--QGGKWVPCGKADTNVQGNRVYMHPDSPNTGAHWMRQEISFGKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNE--MDDKGH-IILQSMHKYKPRVHVIEQGSsvDLSQIQSLPTEgVKTFSFKETEFTTVTAYQNQQITKLKIERNPF 157
Cdd:cd20204  109 LTNNKgaSNNNGQmVVLQSLHKYQPRLHVVEVNE--DGTEDTSQPGR-VQTFTFPETQFIAVTAYQNTDITQLKIDHNPF 185


                 ....*.
gi 744066867 158 AKGFRD 163
Cdd:cd20204  186 AKGFRD 191
T-box_Fungi_incertae_sedis cd20683
T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae ...
 1-164 5.33e-44

T-box DNA-binding domain; uncharacterized subfamily of fungi classified as Fungi incertae sedis; Fungi incertae sedis refers to a fungal taxonomic group where its broader relationships are unknown or undefined. The T-box family is an ancient group that appears to play a critical role in development in all animal species. These genes were uncovered on the basis of similarity to the DNA binding domain of murine Brachyury (T) gene product, the defining feature of the family. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development and conserved expression patterns, most of the known genes in all species being expressed in mesoderm or mesoderm precursors.


Pssm-ID: 410334  Cd Length: 214  Bit Score: 152.16  E-value: 5.33e-44
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVyhSSQWMVAGNTDH------------LCIIPRFYVHPDSPCSGET 68
Cdd:cd20683   30 LFPLLRFRAVNLDPKALYSIALDIEQVSPNRFRFR--NGRWNPIDKDQRgddafssgtadkSVLLPESYIHPDGPQTGAF 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  69 WMRQIISFDRMKLTN-------------NEMDDK-----GHIILQSMHKYKPRVHVIeQGSSVDLSQIQSlptegvKTFS 130
Cdd:cd20683  108 WMANGISFAKIKLSNrqpnssdrdgpkeNITNSIsalpdGHFFLTSFHKYQPRLHLI-QHSAGDHDDILS------TTFT 180

                        170       180       190
                 ....*....|....*....|....*....|....
gi 744066867 131 FKETEFTTVTAYQNQQITKLKIERNPFAKGFRDT 164
Cdd:cd20683  181 FEETEFIAVTHYQNEKVNILKKDYNPHAKGFKDD 214
T-box_TBXT cd20202
DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also ...
 1-163 2.57e-43

DNA-binding domain of T-box transcription factor T and related T-box proteins; TBXT, also known as Brachyury protein, or protein T, is a transcription factor needed for posterior mesoderm formation and differentiation as well as for the notochord development during embryogenesis. It binds to a 24 base-pair (bp) palindromic site (called the T site) and activates gene transcription when bound to such a site. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. TBXT is the founding member of the T-box family, members of which share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410328  Cd Length: 179  Bit Score: 149.03  E-value: 2.57e-43
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVyhSSQWMVAGNTDHL---CIiprfYVHPDSPCSGETWMRQIISFD 77
Cdd:cd20202   31 MFPVLKVNVSGLDPNAMYSFLLDFVAADNHRWKYV--NGEWVPGGKPEPQapsCV----YIHPDSPNFGAHWMKAPVSFS 104

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  78 RMKLTNnEMDDKGHIILQSMHKYKPRVHVIEQGSsvdlsqiqslPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPF 157
Cdd:cd20202  105 KVKLTN-KLNGGGQIMLNSLHKYEPRIHIVRVGG----------PQRMITSHSFPETQFIAVTAYQNEEITALKIKYNPF 173


                 ....*.
gi 744066867 158 AKGFRD 163
Cdd:cd20202  174 AKAFLD 179
T-box_TBR2 cd20205
DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as ...
 1-163 1.44e-42

DNA-binding domain of T-box brain protein 2 and related T-box proteins; TBR2 (also known as Eomesodermin, Eomes, or T-brain-2) is a member of the T-box family of transcription factors and is associated with neurogenesis, cardiogenesis and tumor immune response. This subfamily belongs to the T-box family of transcription factors which plays a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410331  Cd Length: 191  Bit Score: 147.52  E-value: 1.44e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYvyHSSQWMVAGNTDHLCIIPRFYVHPDSPCSGETWMRQIISFDRMK 80
Cdd:cd20205   31 MFPFLSFNITGLNPTAHYNVFVEVVLADPNHWRF--QGGKWVTCGKADNNMQGNKVYVHPESPNTGAHWMRQEISFGKLK 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  81 LTNNE---MDDKGHIILQSMHKYKPRVHVIEqgSSVDLSQIQSLPTEgVKTFSFKETEFTTVTAYQNQQITKLKIERNPF 157
Cdd:cd20205  109 LTNNKganNNNTQMIVLQSLHKYQPRLHIVE--VSEDGVEDLNDSSK-TQTFTFPENQFIAVTAYQNTDITQLKIDHNPF 185


                 ....*.
gi 744066867 158 AKGFRD 163
Cdd:cd20205  186 AKGFRD 191
T-box_TBX19-like cd20201
DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also ...
 1-163 1.59e-42

DNA-binding domain of T-box transcription factor 19 and related T-box proteins; Tbx19 (also known as Tpit) is a T-box factor restricted to two pituitary (pro-opiomelanocortin) POMC-expressing lineages, the corticotrophs and melanotrophs; it controls terminal differentiation of these lineages. TBX19 activates POMC gene transcription with the cooperation of another transcription factor Pitx1. Mutations of the human TPIT gene cause early onset pituitary adrenocorticotrophic hormone (ACTH) deficiency. This subfamily belongs to the T-box family of transcription factors which play a multitude of diverse functions throughout development. The founding member of the T-box family is Brachyury (also known as TBXT, or T). T-box family members share a conserved DNA-binding domain (T-box) which binds DNA in a sequence-specific manner. Common features shared by T-box family members are DNA-binding and transcriptional regulatory activity, a role in development, and conserved expression patterns.


Pssm-ID: 410327  Cd Length: 183  Bit Score: 147.10  E-value: 1.59e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867   1 MFPSVRVKVKGLDPGKQYHVAIDVVPVDSKRYRYVyhSSQWMVAGNTD---HLCIiprfYVHPDSPCSGETWMRQIISFD 77
Cdd:cd20201   35 MFPVLKISVSGLDPNAMYSFLLDFAPADGHRWKYV--NGEWVPAGKPEphsHSCV----YIHPDSPNFGAHWMKAPISFS 108

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 744066867  78 RMKLTNnEMDDKGHIILQSMHKYKPRVHVIEQGSsvdlsqiqslPTEGVKTFSFKETEFTTVTAYQNQQITKLKIERNPF 157
Cdd:cd20201  109 KVKLTN-KLNGGGQIMLNSLHKYEPQIHIVRVGG----------PHRMVTNCSFPETQFIAVTAYQNEEITALKIKYNPF 177


                 ....*.
gi 744066867 158 AKGFRD 163
Cdd:cd20201  178 AKAFLD 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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