NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|735997384|ref|NP_001290176|]
View 

superkiller complex protein 8 isoform a [Homo sapiens]

Protein Classification

WD40 repeat domain-containing protein( domain architecture ID 11455410)

WD40 repeat domain-containing protein similar to proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly

CATH:  2.130.10.10
PubMed:  10322433|8090199
SCOP:  4002744

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-302 6.89e-75

WD40 repeat [General function prediction only];


:

Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.19  E-value: 6.89e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   6 GILFKQEQAHDDAIWSVAWGtnkkENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLD 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS----PDGKTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  86 AHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 735997384 246 HFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-302 6.89e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.19  E-value: 6.89e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   6 GILFKQEQAHDDAIWSVAWGtnkkENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLD 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS----PDGKTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  86 AHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 735997384 246 HFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-302 2.19e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.79  E-value: 2.19e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  13 QAHDDAIWSVAWGtnkkENSETVVTGSLDDLVKVWKWrdERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Cdd:cd00200    6 KGHTGGVTCVAFS----PDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  93 LENGKQIKSI--DAGPVdaWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
Cdd:cd00200   80 LETGECVRTLtgHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 171 IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSS 250
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 735997384 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 9.07e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 9.07e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 735997384   179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 112-199 3.27e-09

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 53.05  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  112 LAFSPDSQYLATGTHVGKVNIFGVeSGKKEY--SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRL-NWQRVWtlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 735997384  190 AMPIRSLTFS 199
Cdd:pfam12894  80 SDLITCLGWG 89
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-219 5.56e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAF-SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP 158
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997384 159 DGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSpDSQLLVTASDDGYIKIYDV 219
Cdd:PLN00181 629 SGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
 
Name Accession Description Interval E-value
WD40 COG2319
WD40 repeat [General function prediction only];
6-302 6.89e-75

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 235.19  E-value: 6.89e-75
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   6 GILFKQEQAHDDAIWSVAWGtnkkENSETVVTGSLDDLVKVWKWRDERLdlQWSLEGHQLGVVSVDISHTLPIAASSSLD 85
Cdd:COG2319  110 GLLLRTLTGHTGAVRSVAFS----PDGKTLASGSADGTVRLWDLATGKL--LRTLTGHSGAVTSVAFSPDGKLLASGSDD 183

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  86 AHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165
Cdd:COG2319  184 GTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLAS 263

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
Cdd:COG2319  264 GSADGTVRLWDLATGELLRTLTGHSGGVNSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGK 343

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 735997384 246 HFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:COG2319  344 TLASGSDDGTVRLWDLATGELLRTLTGHTGAVTSVAFSPDGRTLASGSADGTVRLWD 400
WD40 COG2319
WD40 repeat [General function prediction only];
36-302 3.48e-64

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 207.46  E-value: 3.48e-64
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
Cdd:COG2319   50 RLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFSPDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFS 129

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
Cdd:COG2319  130 PDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTSVAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRS 209

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQD 275
Cdd:COG2319  210 VAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSGSVRSVAFSPDGRLLASGSADGTVRLWDLATGELLRTLTGHSG 289

                        250       260
                 ....*....|....*....|....*..
gi 735997384 276 QVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:COG2319  290 GVNSVAFSPDGKLLASGSDDGTVRLWD 316
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 13-302 2.19e-61

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 196.79  E-value: 2.19e-61
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  13 QAHDDAIWSVAWGtnkkENSETVVTGSLDDLVKVWKWrdERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Cdd:cd00200    6 KGHTGGVTCVAFS----PDGKLLATGSGDGTIKVWDL--ETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWD 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  93 LENGKQIKSI--DAGPVdaWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDG 170
Cdd:cd00200   80 LETGECVRTLtgHTSYV--SSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDG 157

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 171 IINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSS 250
Cdd:cd00200  158 TIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASG 237

                        250       260       270       280       290
                 ....*....|....*....|....*....|....*....|....*....|..
gi 735997384 251 SSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:cd00200  238 SEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGKRLASGSADGTIRIWD 289
WD40 COG2319
WD40 repeat [General function prediction only];
36-302 2.67e-56

WD40 repeat [General function prediction only];


Pssm-ID: 441893 [Multi-domain]  Cd Length: 403  Bit Score: 187.04  E-value: 2.67e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  36 VTGSLDDLVKVWKWRDERLDLQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFS 115
Cdd:COG2319    8 ALAAASADLALALLAAALGALLLLLLGLAAAVASLAASPDGARLAAGAGDLTLLLLDAAAGALLATLLGHTAAVLSVAFS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 116 PDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRS 195
Cdd:COG2319   88 PDGRLLASASADGTVRLWDLATGLLLRTLTGHTGAVRSVAFSPDGKTLASGSADGTVRLWDLATGKLLRTLTGHSGAVTS 167

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 196 LTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQD 275
Cdd:COG2319  168 VAFSPDGKLLASGSDDGTVRLWDLATGKLLRTLTGHTGAVRSVAFSPDGKLLASGSADGTVRLWDLATGKLLRTLTGHSG 247

                        250       260
                 ....*....|....*....|....*..
gi 735997384 276 QVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:COG2319  248 SVRSVAFSPDGRLLASGSADGTVRLWD 274
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 6-260 2.00e-50

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 168.28  E-value: 2.00e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   6 GILFKQEQAHDDAIWSVAWGTNkkenSETVVTGSLDDLVKVWKWRDERLDlqWSLEGHQLGVVSVDISHTLPIAASSSLD 85
Cdd:cd00200   41 GELLRTLKGHTGPVRDVAASAD----GTYLASGSSDKTIRLWDLETGECV--RTLTGHTSYVSSVAFSPDGRILSSSSRD 114

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  86 AHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSPDGKYLAS 165
Cdd:cd00200  115 KTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDLRTGKCVATLTGHTGEVNSVAFSPDGEKLLS 194

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 166 GAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDT 245
Cdd:cd00200  195 SSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIRVWDLRTGECVQTLSGHTNSVTSLAWSPDGK 274

                        250
                 ....*....|....*
gi 735997384 246 HFVSSSSDKSVKVWD 260
Cdd:cd00200  275 RLASGSADGTIRIWD 289
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 60-302 3.65e-49

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 165.20  E-value: 3.65e-49
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  60 LEGHQLGVVSVDISHTLPIAASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK 139
Cdd:cd00200    5 LKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDLETGE 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 140 KEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDV 219
Cdd:cd00200   85 CVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWDVETGKCLTTLRGHTDWVNSVAFSPDGTFVASSSQDGTIKLWDL 164

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 220 QHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIH 299
Cdd:cd00200  165 RTGKCVATLTGHTGEVNSVAFSPDGEKLLSSSSDGTIKLWDLSTGKCLGTLRGHENGVNSVAFSPDGYLLASGSEDGTIR 244


                 ...
gi 735997384 300 IYD 302
Cdd:cd00200  245 VWD 247
WD40 cd00200
WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions ...
 182-302 5.40e-22

WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from its N-terminus and the WD dipeptide at its C-terminus and is 40 residues long, hence the name WD40; between GH and WD lies a conserved core; serves as a stable propeller-like platform to which proteins can bind either stably or reversibly; forms a propeller-like structure with several blades where each blade is composed of a four-stranded anti-parallel b-sheet; instances with few detectable copies are hypothesized to form larger structures by dimerization; each WD40 sequence repeat forms the first three strands of one blade and the last strand in the next blade; the last C-terminal WD40 repeat completes the blade structure of the first WD40 repeat to create the closed ring propeller-structure; residues on the top and bottom surface of the propeller are proposed to coordinate interactions with other proteins and/or small ligands; 7 copies of the repeat are present in this alignment.


Pssm-ID: 238121 [Multi-domain]  Cd Length: 289  Bit Score: 93.17  E-value: 5.40e-22
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFCPDDTHFVSSSSDKSVKVWDV 261
Cdd:cd00200    1 LRRTLKGHTGGVTCVAFSPDGKLLATGSGDGTIKVWDLETGELLRTLKGHTGPVRDVAASADGTYLASGSSDKTIRLWDL 80

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|.
gi 735997384 262 GTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:cd00200   81 ETGECVRTLTGHTSYVSSVAFSPDGRILSSSSRDKTIKVWD 121
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
78-212 3.28e-12

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 65.10  E-value: 3.28e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  78 IAASSSLDAHIRLWDLENGKQIKSIDAGPvDAWTLAFSPDSQYL-ATGTHVGKVNIFGVESGKKEYSLDTrGKFILSIAY 156
Cdd:COG3391   82 LYVANSGSGRVSVIDLATGKVVATIPVGG-GPRGLAVDPDGGRLyVADSGNGRVSVIDTATGKVVATIPV-GAGPHGIAV 159

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997384 157 SPDGKYL-----ASGAIDGIINIFDIATGKLLHTLEGHAMPIrSLTFSPD-SQLLVTASDDG 212
Cdd:COG3391  160 DPDGKRLyvansGSNTVSVIVSVIDTATGKVVATIPVGGGPV-GVAVSPDgRRLYVANRGSN 220
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 179-218 9.07e-10

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 53.09  E-value: 9.07e-10
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 735997384   179 TGKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
TolB COG0823
Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, ...
 78-219 1.62e-09

Periplasmic component TolB of the Tol biopolymer transport system [Intracellular trafficking, secretion, and vesicular transport];


Pssm-ID: 440585 [Multi-domain]  Cd Length: 158  Bit Score: 55.83  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  78 IAASSSLD--AHIRLWDLENGKQIK-----SIDAGPvdawtlAFSPDSQYLA-TGTHVGKVNIFGVE-SGKKEYSLDTRG 148
Cdd:COG0823    1 LAFTLSRDgnSDIYVVDLDGGEPRRltnspGIDTSP------AWSPDGRRIAfTSDRGGGPQIYVVDaDGGEPRRLTFGG 74

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 735997384 149 KFILSIAYSPDGKYLA-SGAIDGIINIF--DIATGKLLHTLEGHAMPirslTFSPDSQLLVTASD-DGYIKIYDV 219
Cdd:COG0823   75 GYNASPSWSPDGKRLAfVSRSDGRFDIYvlDLDGGAPRRLTDGPGSP----SWSPDGRRIVFSSDrGGRPDLYVV 145
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 112-199 3.27e-09

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 53.05  E-value: 3.27e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  112 LAFSPDSQYLATGTHVGKVNIFGVeSGKKEY--SLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGH 189
Cdd:pfam12894   1 MSWCPTMDLIALATEDGELLLHRL-NWQRVWtlSPDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAG 79

                          90
                  ....*....|
gi 735997384  190 AMPIRSLTFS 199
Cdd:pfam12894  80 SDLITCLGWG 89
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 113-220 4.11e-09

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 57.36  E-value: 4.11e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  113 AFSPDSQYLATGTHVG---KVNIFGVESGKKEYSL-DTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGK---LLHt 185
Cdd:COG4946   349 AWSPDGKSIAYFSDASgeyELYIAPADGSGEPKQLtLGDLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKvrkVDT- 427

                          90       100       110
                  ....*....|....*....|....*....|....*....
gi 735997384  186 lEGHAMPIRSLTFSPDSQLLVTASDDGY----IKIYDVQ 220
Cdd:COG4946   428 -DGYGDGISDLAWSPDSKWLAYSKPGPNqlsqIFLYDVE 465
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 80-219 5.56e-09

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 57.02  E-value: 5.56e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  80 ASSSLDAHIRLWDLENGKQIKSIDAGPVDAWTLAF-SPDSQYLATGTHVGKVNIFGVESGKKEYSLDTRGKFILSIAYSP 158
Cdd:PLN00181 549 ASSNFEGVVQVWDVARSQLVTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKANICCVQFPSE 628

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997384 159 DGKYLASGAIDGIINIFDIATGKL-LHTLEGHAMPIRSLTFSpDSQLLVTASDDGYIKIYDV 219
Cdd:PLN00181 629 SGRSLAFGSADHKVYYYDLRNPKLpLCTMIGHSKTVSYVRFV-DSSTLVSSSTDNTLKLWDL 689
WD40 pfam00400
WD domain, G-beta repeat;
180-218 8.47e-09

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 50.42  E-value: 8.47e-09
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 735997384  180 GKLLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYD 218
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 92-181 1.44e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 52.73  E-value: 1.44e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   92 DLENGKQIKSIDAG-PVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGK-KEYSLDTRGKFILSIAYSPDGKYLASGAID 169
Cdd:COG4946   373 PADGSGEPKQLTLGdLGRVFNPVWSPDGKKIAFTDNRGRLWVVDLASGKvRKVDTDGYGDGISDLAWSPDSKWLAYSKPG 452

                          90
                  ....*....|....*.
gi 735997384  170 G----IINIFDIATGK 181
Cdd:COG4946   453 PnqlsQIFLYDVETGK 468
YncE COG3391
DNA-binding beta-propeller fold protein YncE [General function prediction only];
98-246 3.28e-07

DNA-binding beta-propeller fold protein YncE [General function prediction only];


Pssm-ID: 442618 [Multi-domain]  Cd Length: 237  Bit Score: 50.46  E-value: 3.28e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  98 QIKSIDAGPVDAWTLAFSPDSQYL-ATGTHVGKVNIFGVESGKKEYSLDTrGKFILSIAYSPDGKYL-ASGAIDGIINIF 175
Cdd:COG3391   59 GLGLGAAAVADADGADAGADGRRLyVANSGSGRVSVIDLATGKVVATIPV-GGGPRGLAVDPDGGRLyVADSGNGRVSVI 137

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 735997384 176 DIATGKLLHTLEGHAMPiRSLTFSPDSQLLVTASDDG-----YIKIYDVQHANLAGTLSGHASWVlNVAFCPDDTH 246
Cdd:COG3391  138 DTATGKVVATIPVGAGP-HGIAVDPDGKRLYVANSGSntvsvIVSVIDTATGKVVATIPVGGGPV-GVAVSPDGRR 211
COG4946 COG4946
Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown] ...
 89-164 5.24e-07

Uncharacterized N-terminal domain of tricorn protease, contains WD40 repeats [Function unknown];


Pssm-ID: 443973 [Multi-domain]  Cd Length: 1072  Bit Score: 51.19  E-value: 5.24e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384   89 RLW--DLENGKQIKsIDAGP--VDAWTLAFSPDSQYLA----TGTHVGKVNIFGVESGKKeYSLdTRGKFI-LSIAYSPD 159
Cdd:COG4946   411 RLWvvDLASGKVRK-VDTDGygDGISDLAWSPDSKWLAyskpGPNQLSQIFLYDVETGKT-VQL-TDGRYDdGSPAFSPD 487


                  ....*
gi 735997384  160 GKYLA 164
Cdd:COG4946   488 GKYLY 492
PLN00181 PLN00181
protein SPA1-RELATED; Provisional
 112-245 8.79e-07

protein SPA1-RELATED; Provisional


Pssm-ID: 177776 [Multi-domain]  Cd Length: 793  Bit Score: 50.09  E-value: 8.79e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 112 LAFSPDSQYLATGTHVGKVNIFGVESGKKE--------YSLDTRGKfILSIAYSPDGK-YLASGAIDGIINIFDIATGKL 182
Cdd:PLN00181 489 IGFDRDGEFFATAGVNKKIKIFECESIIKDgrdihypvVELASRSK-LSGICWNSYIKsQVASSNFEGVVQVWDVARSQL 567

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 735997384 183 LHTLEGHAMPIRSLTF-SPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASwVLNVAFcPDDT 245
Cdd:PLN00181 568 VTEMKEHEKRVWSIDYsSADPTLLASGSDDGSVKLWSINQGVSIGTIKTKAN-ICCVQF-PSES 629
PTZ00421 PTZ00421
coronin; Provisional
 112-233 1.41e-06

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 49.51  E-value: 1.41e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 112 LAFSP-DSQYLATGTHVGKVNIFGV-ESGKKEYSLD--------TRGKFILSIAYSPDGkYLASGAIDGIINIFDIATGK 181
Cdd:PTZ00421  81 VAFNPfDPQKLFTASEDGTIMGWGIpEEGLTQNISDpivhlqghTKKVGIVSFHPSAMN-VLASAGADMVVNVWDVERGK 159

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|..
gi 735997384 182 LLHTLEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHAS 233
Cdd:PTZ00421 160 AVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIIDPRDGTIVSSVEAHAS 211
8prop_hemeD1_NirF cd20778
eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; ...
 86-218 3.85e-06

eight-bladed heme d1-binding beta-propeller domain in cytochrome cd1 nitrate reductase NirF; Denitrification is a process that enables biofilm formation of the opportunistic human pathogen Pseudomonas aeruginosa, making it more resilient to antibiotics and highly adaptable to different habitats. During denitrification, nitrate (Nar), nitrite (Nir), nitric oxide (Nor), and nitrous oxide (Nos) reductases catalyze the reaction cascade of NO3- -> NO2- -> NO -> N2O -> N2. The integral membrane proteins NorC, NorB, and NosR form the core assembly platform that binds the nitrate reductase NarGHI and the periplasmic cytochrome cd1 (nitrite reductase) NirS via its maturation factor NirF. The nirFDLGHJE genes encode proteins required for heme d1 biosynthesis. NirS, NirF, and NirN, the monomeric dihydro-heme d1 dehydrogenase form a stable complex during nitrite reductase maturation. The nitrite reductase NirS is bound to the denitrification supercomplex via NorB, while the electron donor system NirM and the enzyme maturation machinery NirN-NirF-NirQ, interacting with NirS, are bound via NorC.


Pssm-ID: 467722 [Multi-domain]  Cd Length: 381  Bit Score: 47.66  E-value: 3.85e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  86 AHIRLWDLENGKQIKSIDAG------PVD------AWtlAFSPDSQYL-ATGTHvgKVNIFGVESGKKEYSLDTRGKFIL 152
Cdd:cd20778  210 GLLDLWKPERGVRRILLDYGkgeeklPVYkmphleGW--AVAGDKAFVpAVGEH--RVLVYDTNDWKFIKSIPLAGQPVF 285

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 735997384 153 SIAySPDGKYLA---SGAIDGIINIFDIATGKLLHTLE--GHAMPIRsltFSPD-SQLLVTASDDGYIKIYD 218
Cdd:cd20778  286 AVA-RPDGRYVWvnfSGPDNDTVQVIDTKTLKVVKTLEpgKRVLHME---FTPRgEAVYISVNDDNKVVVYD 353
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 263-302 1.41e-05

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 41.53  E-value: 1.41e-05
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 735997384   263 TRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
Nsa1_WDR74-like cd22850
Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 ...
 87-184 2.02e-05

Ribosome biogenesis protein Nsa1 and similar proteins; Ribosome biogenesis protein Nsa1 (Nop7-associated 1) from fungi and WDR74 (WD repeat-containing protein 74) from mammals and plants, are homologous essential factors for ribosome assembly. In cooperation with the assembly factor Rix7/NVL2, Nsa1/WDR74 participates in an early cleavage of the pre-rRNA processing pathway. Rix7/NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of Nsa1/WDR74 from nucleolar pre-60S particles. Nsa1/WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase Rix7/NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439302 [Multi-domain]  Cd Length: 333  Bit Score: 45.31  E-value: 2.02e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  87 HIRLWDLENG-KQIKSIDAGPvdawTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLdtRGKF---ILSIAYSPD--G 160
Cdd:cd22850  216 QVRLYDTSAGrRPVFSEKPIK----KPEEDLDGHTVYVGDTSGDLALIDIRTGKLLGRL--LGKYggsITGAVRHPElfD 289

                         90       100
                 ....*....|....*....|....
gi 735997384 161 KYLASGAIDGIINIFDIATGKLLH 184
Cdd:cd22850  290 PYLASGGLDRYLRVFDIETRELLA 313
PTZ00421 PTZ00421
coronin; Provisional
 188-302 3.61e-05

coronin; Provisional


Pssm-ID: 173611 [Multi-domain]  Cd Length: 493  Bit Score: 44.88  E-value: 3.61e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 188 GHAMPIRSLTFSP-DSQLLVTASDDGYIKIYDVQHANLAGTLS-------GHASWVLNVAFCPDDTH-FVSSSSDKSVKV 258
Cdd:PTZ00421  73 GQEGPIIDVAFNPfDPQKLFTASEDGTIMGWGIPEEGLTQNISdpivhlqGHTKKVGIVSFHPSAMNvLASAGADMVVNV 152

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....
gi 735997384 259 WDVGTRTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:PTZ00421 153 WDVERGKAVEVIKCHSDQITSLEWNLDGSLLCTTSKDKKLNIID 196
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 116-220 1.92e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 42.60  E-value: 1.92e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384 116 PDSQYLATGTHVGKVNIFGVESGKKE-YSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFDIATGKLLHTLEGHA-MPI 193
Cdd:cd22857  190 DDHRKIVTGTGYHQVRLYDTRAQRRPvVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCFKGKCgGSI 269

                         90       100
                 ....*....|....*....|....*..
gi 735997384 194 RSLTFSPDSQLLVTASDDGYIKIYDVQ 220
Cdd:cd22857  270 RSIARHPELPLIASCGLDRYLRIWDTE 296
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 137-176 2.83e-04

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 37.68  E-value: 2.83e-04
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|
gi 735997384   137 SGKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Cdd:smart00320   1 SGELLKTLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
eIF2A pfam08662
Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation ...
 143-247 3.84e-04

Eukaryotic translation initiation factor eIF2A; This is a family of eukaryotic translation initiation factors.


Pssm-ID: 462552 [Multi-domain]  Cd Length: 194  Bit Score: 40.72  E-value: 3.84e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  143 SLDTRGKfILSIAYSPDGK--YLASGAIDGIINIFDiATGKLLHTLEGHamPIRSLTFSPDSQLLVTA---SDDGYIKIY 217
Cdd:pfam08662  55 ELDKEGP-IHDVAWSPNGKefAVIYGYMPAKVSFFD-LKGNVIHSFGEQ--PRNTIFWSPFGRLVLLAgfgNLAGDIEFW 130

                          90       100       110
                  ....*....|....*....|....*....|
gi 735997384  218 DVQHANLAGTLsgHASWVLNVAFCPDDTHF 247
Cdd:pfam08662 131 DVVNKKKIATA--EASNATLCEWSPDGRYF 158
WD40 pfam00400
WD domain, G-beta repeat;
264-302 7.53e-04

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.55  E-value: 7.53e-04
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 735997384  264 RTCVHTFFDHQDQVWGVKYNGNGSKIVSVGDDQEIHIYD 302
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WDR74 cd22857
WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and ...
 87-184 8.21e-04

WD repeat-containing protein 74; WDR74 (WD repeat-containing protein 74) from mammals and plants is an essential factor for ribosome assembly. In cooperation with the assembly factor NVL2, WDR74 participates in an early cleavage of the pre-rRNA processing pathway. NVL2 is a type II double ring, AAA-ATPase, that may mediate the release of WDR74 from nucleolar pre-60S particles. WDR74 has been implicated in tumorigenesis. In lung cancer, it regulates cell proliferation, cell cycle progression, chemoresistance and cell aggressiveness, by inducing nuclear beta-catenin accumulation and driving downstream Wnt-responsive genes expression. In melanoma, it promotes apoptosis resistance and aggressive behavior by regulating the RPL5-MDM2-p53 pathway. WDR74 contains an N-terminal seven-bladed beta-propeller WD40 domain that associates with the D1-AAA domain of the AAA-ATPase NVL2, and a flexible lysine-rich C-terminus that extends outward from the WD40 domain, and is required for nucleolar localization.


Pssm-ID: 439303 [Multi-domain]  Cd Length: 325  Bit Score: 40.29  E-value: 8.21e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  87 HIRLWDLENGKQ-IKSIDAGPVDAWTLAFSPDSQYLATGTHVGKVNIFGVESGKKEYSLdtRGK---FILSIAYSPDGKY 162
Cdd:cd22857  203 QVRLYDTRAQRRpVVSVDFGETPIKAVAEDPDGHTVYVGDTSGDLASIDLRTGKLLGCF--KGKcggSIRSIARHPELPL 280

                         90       100
                 ....*....|....*....|..
gi 735997384 163 LASGAIDGIINIFDIATGKLLH 184
Cdd:cd22857  281 IASCGLDRYLRIWDTETRQLLS 302
WD40 pfam00400
WD domain, G-beta repeat;
138-176 1.06e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 36.17  E-value: 1.06e-03
                          10        20        30
                  ....*....|....*....|....*....|....*....
gi 735997384  138 GKKEYSLDTRGKFILSIAYSPDGKYLASGAIDGIINIFD 176
Cdd:pfam00400   1 GKLLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 pfam00400
WD domain, G-beta repeat;
56-92 1.84e-03

WD domain, G-beta repeat;


Pssm-ID: 459801 [Multi-domain]  Cd Length: 39  Bit Score: 35.40  E-value: 1.84e-03
                          10        20        30
                  ....*....|....*....|....*....|....*..
gi 735997384   56 LQWSLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Cdd:pfam00400   3 LLKTLEGHTGSVTSLAFSPDGKLLASGSDDGTVKVWD 39
WD40 smart00320
WD40 repeats; Note that these repeats are permuted with respect to the structural repeats ...
 59-92 2.75e-03

WD40 repeats; Note that these repeats are permuted with respect to the structural repeats (blades) of the beta propeller domain.


Pssm-ID: 197651 [Multi-domain]  Cd Length: 40  Bit Score: 34.98  E-value: 2.75e-03
                           10        20        30
                   ....*....|....*....|....*....|....
gi 735997384    59 SLEGHQLGVVSVDISHTLPIAASSSLDAHIRLWD 92
Cdd:smart00320   7 TLKGHTGPVTSVAFSPDGKYLASGSDDGTIKLWD 40
PTZ00420 PTZ00420
coronin; Provisional
 32-157 3.43e-03

coronin; Provisional


Pssm-ID: 240412 [Multi-domain]  Cd Length: 568  Bit Score: 38.78  E-value: 3.43e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 735997384  32 SETVVTGSLDDLVKVWKWR--DERL----DLQWSLEGHQLGVVSVDIS-HTLPIAASSSLDAHIRLWDLENGKQIKSIDA 104
Cdd:PTZ00420  87 SEILASGSEDLTIRVWEIPhnDESVkeikDPQCILKGHKKKISIIDWNpMNYYIMCSSGFDSFVNIWDIENEKRAFQINM 166

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 735997384 105 gPVDAWTLAFSPDSQYLaTGTHVGK------------VNIFGVESGKKEYS---LDTRG---KFILSIAYS 157
Cdd:PTZ00420 167 -PKKLSSLKWNIKGNLL-SGTCVGKhmhiidprkqeiASSFHIHDGGKNTKniwIDGLGgddNYILSTGFS 235
ANAPC4_WD40 pfam12894
Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped ...
 186-241 4.42e-03

Anaphase-promoting complex subunit 4 WD40 domain; Apc4 contains an N-terminal propeller-shaped WD40 domain.The N-terminus of Afi1 serves to stabilize the union between Apc4 and Apc5, both of which lie towards the bottom-front of the APC,


Pssm-ID: 403945 [Multi-domain]  Cd Length: 91  Bit Score: 35.72  E-value: 4.42e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|....*.
gi 735997384  186 LEGHAMPIRSLTFSPDSQLLVTASDDGYIKIYDVQHANLAGTLSGHASWVLNVAFC 241
Cdd:pfam12894  34 PDKEDLEVTSLAWRPDGKLLAVGYSDGTVRLLDAENGKIVHHFSAGSDLITCLGWG 89
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH