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Conserved domains on  [gi|732662978|ref|NP_001289959|]
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AFG2-interacting ribosome maturation factor isoform 2 [Homo sapiens]

Protein Classification

CK2S domain-containing protein( domain architecture ID 10633225)

CK2S domain-containing protein

Graphical summary

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List of domain hits

Name Accession Description Interval E-value
CK2S pfam15011
Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the ...
75-236 4.35e-66

Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterized. It is found to be localized in the nucleus and cytoplasm. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.


:

Pssm-ID: 464443  Cd Length: 161  Bit Score: 202.90  E-value: 4.35e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978   75 ALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPaLRAFPDLKERLRRKQLVAGDIVLDKLGERL 154
Cdd:pfam15011   1 KLRKKFRKVEEQMDRWDSLLSRCLSLLSSLSNLAEQLQALQNVKLYGTP-LRCFPDLQERLRGKQMEALETVLLKLREKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978  155 AILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQ 234
Cdd:pfam15011  80 EEFQKVRDSLSKQVRDVFQLYEQHADELGLKALQQRSGVSPSLADMLEWLQDIERMYRSEYLLKKSLLSTLTYSDLSDLQ 159

                  ..
gi 732662978  235 AL 236
Cdd:pfam15011 160 AL 161
 
Name Accession Description Interval E-value
CK2S pfam15011
Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the ...
75-236 4.35e-66

Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterized. It is found to be localized in the nucleus and cytoplasm. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.


Pssm-ID: 464443  Cd Length: 161  Bit Score: 202.90  E-value: 4.35e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978   75 ALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPaLRAFPDLKERLRRKQLVAGDIVLDKLGERL 154
Cdd:pfam15011   1 KLRKKFRKVEEQMDRWDSLLSRCLSLLSSLSNLAEQLQALQNVKLYGTP-LRCFPDLQERLRGKQMEALETVLLKLREKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978  155 AILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQ 234
Cdd:pfam15011  80 EEFQKVRDSLSKQVRDVFQLYEQHADELGLKALQQRSGVSPSLADMLEWLQDIERMYRSEYLLKKSLLSTLTYSDLSDLQ 159

                  ..
gi 732662978  235 AL 236
Cdd:pfam15011 160 AL 161
 
Name Accession Description Interval E-value
CK2S pfam15011
Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the ...
75-236 4.35e-66

Casein Kinase 2 substrate; It is suggested that CK2S (C10orf109) is important in the regulation of cancer cell proliferation. Studies have indicated that CK2S is the downstream target of a protein kinase, casein kinase 2 (CK2), which is upregulated in cancer cells. CK2S has been found to be upregulated in cancer cells. The precise mechanism of CK2 targetting CK2S is not well characterized. It is found to be localized in the nucleus and cytoplasm. This family of proteins is found in eukaryotes. Proteins in this family are typically between 160 and 221 amino acids in length. There is a single completely conserved residue P that may be functionally important.


Pssm-ID: 464443  Cd Length: 161  Bit Score: 202.90  E-value: 4.35e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978   75 ALKKCFPVVEEQQGLWQSALRDCQPLLSSLSNLAEQLQAAQNLRFEDVPaLRAFPDLKERLRRKQLVAGDIVLDKLGERL 154
Cdd:pfam15011   1 KLRKKFRKVEEQMDRWDSLLSRCLSLLSSLSNLAEQLQALQNVKLYGTP-LRCFPDLQERLRGKQMEALETVLLKLREKL 79
                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 732662978  155 AILLKVRDMVSSHVERVFQIYEQHADTVGIDAVLQPSAVSPSVADMLEWLQDIERHYRKSYLKRKYLLSSIQWGDLANIQ 234
Cdd:pfam15011  80 EEFQKVRDSLSKQVRDVFQLYEQHADELGLKALQQRSGVSPSLADMLEWLQDIERMYRSEYLLKKSLLSTLTYSDLSDLQ 159

                  ..
gi 732662978  235 AL 236
Cdd:pfam15011 160 AL 161
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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