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Conserved domains on  [gi|1646805393|ref|NP_001289582|]
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cytochrome c oxidase assembly factor 8 isoform 3 [Homo sapiens]

Protein Classification

APOPT family protein( domain architecture ID 10885)

APOPT family protein is a DUF2315 domain-containing protein similar to Caenorhabditis elegans mitochondrial COA8 family protein Y39B6A.34, which may be required for cytochrome c complex (COX) assembly and function, COX being the terminal component of the mitochondrial respiratory chain

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COA8 super family cl10916
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 53-127 7.06e-46

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


The actual alignment was detected with superfamily member pfam10231:

Pssm-ID: 463011  Cd Length: 119  Bit Score: 146.63  E-value: 7.06e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1646805393  53 HDWIGPPDKYSNLRPVHFYIPENESPLEQKLRKLRQETQEWNQQFWANQNLTFSKEKEEFIHSRLKTKGLGLRTE 127
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEERAG 75
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 53-127 7.06e-46

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 146.63  E-value: 7.06e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1646805393  53 HDWIGPPDKYSNLRPVHFYIPENESPLEQKLRKLRQETQEWNQQFWANQNLTFSKEKEEFIHSRLKTKGLGLRTE 127
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEERAG 75
 
Name Accession Description Interval E-value
COA8 pfam10231
Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome ...
 53-127 7.06e-46

Cytochrome c oxidase assembly factor 8; Apoptogenic protein 1 (Apop1, also known as cytochrome c oxidase assembly factor 8), previously thought to induce apoptosis through the Cyclophilin-D-dependent pathway, is required for cytochrome c oxidase (COX) assembly and function. Apop1 is controlled by the ubiquitination-proteasome system (UPS). In Drosophila melanogaster, Apop1 is also involved in neurological impairment, COX enzymatic activity, and resistance to oxidative stress conditions.


Pssm-ID: 463011  Cd Length: 119  Bit Score: 146.63  E-value: 7.06e-46
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 1646805393  53 HDWIGPPDKYSNLRPVHFYIPENESPLEQKLRKLRQETQEWNQQFWANQNLTFSKEKEEFIHSRLKTKGLGLRTE 127
Cdd:pfam10231   1 HDWIGPPDPVSNLRPIIYHIPENETPLERQLRELRQETQAWNQEFWTKHNTRFSKEKEEFIESLLKAKGLEERAG 75
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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