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Conserved domains on  [gi|701462854|ref|NP_001289564|]
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phosphatase and actin regulator 1 isoform 4 [Mus musculus]

Protein Classification

RPEL repeat-containing protein( domain architecture ID 10499653)

RPEL repeat-containing protein such as Phactrs 1-4, a family of protein phosphatase 1 and actin regulatory proteins

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
461-485 4.70e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 43.23  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*
gi 701462854   461 KLTRRLSQRPTAEELEQRNILKPRN 485
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
498-523 2.23e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


:

Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 2.23e-05
                           10        20
                   ....*....|....*....|....*.
gi 701462854   498 RRLTRKLSQRPTVEELRERKILIRFS 523
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 140-161 4.52e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 40.33  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|..
gi 701462854  140 LERKISMRQSREELIKRGVLKE 161
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 423-444 1.01e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


:

Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.48  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|..
gi 701462854  423 SLAIKLSNRPSKRELEEKNILP 444
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
Atrophin-1 super family cl38111
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 173-383 3.88e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


The actual alignment was detected with superfamily member pfam03154:

Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  173 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 245
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  246 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 313
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  314 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 383
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
461-485 4.70e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 43.23  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*
gi 701462854   461 KLTRRLSQRPTAEELEQRNILKPRN 485
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 461-483 8.90e-06

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 42.26  E-value: 8.90e-06
                          10        20
                  ....*....|....*....|...
gi 701462854  461 KLTRRLSQRPTAEELEQRNILKP 483
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
498-523 2.23e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 2.23e-05
                           10        20
                   ....*....|....*....|....*.
gi 701462854   498 RRLTRKLSQRPTVEELRERKILIRFS 523
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 140-161 4.52e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 40.33  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|..
gi 701462854  140 LERKISMRQSREELIKRGVLKE 161
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 499-519 6.57e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 37.25  E-value: 6.57e-04
                          10        20
                  ....*....|....*....|.
gi 701462854  499 RLTRKLSQRPTVEELRERKIL 519
Cdd:pfam02755   1 SLERKLSHRPTREELVERNIL 21
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 423-444 1.01e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.48  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|..
gi 701462854  423 SLAIKLSNRPSKRELEEKNILP 444
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
422-446 1.04e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*
gi 701462854   422 DSLAIKLSNRPSKRELEEKNILPRQ 446
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKEL 25
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
140-161 3.45e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.15  E-value: 3.45e-03
                           10        20
                   ....*....|....*....|..
gi 701462854   140 LERKISMRQSREELIKRGVLKE 161
Cdd:smart00707   3 LNRKLSQRPTREELEERNILKE 24
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 173-383 3.88e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  173 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 245
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  246 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 313
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  314 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 383
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Name Accession Description Interval E-value
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
461-485 4.70e-06

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 43.23  E-value: 4.70e-06
                           10        20
                   ....*....|....*....|....*
gi 701462854   461 KLTRRLSQRPTAEELEQRNILKPRN 485
Cdd:smart00707   2 VLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 461-483 8.90e-06

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 42.26  E-value: 8.90e-06
                          10        20
                  ....*....|....*....|...
gi 701462854  461 KLTRRLSQRPTAEELEQRNILKP 483
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILPE 23
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
498-523 2.23e-05

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 41.31  E-value: 2.23e-05
                           10        20
                   ....*....|....*....|....*.
gi 701462854   498 RRLTRKLSQRPTVEELRERKILIRFS 523
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKELS 26
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 140-161 4.52e-05

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 40.33  E-value: 4.52e-05
                          10        20
                  ....*....|....*....|..
gi 701462854  140 LERKISMRQSREELIKRGVLKE 161
Cdd:pfam02755   2 LERKLSHRPTREELVERNILPE 23
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 499-519 6.57e-04

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 37.25  E-value: 6.57e-04
                          10        20
                  ....*....|....*....|.
gi 701462854  499 RLTRKLSQRPTVEELRERKIL 519
Cdd:pfam02755   1 SLERKLSHRPTREELVERNIL 21
RPEL pfam02755
RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL ...
 423-444 1.01e-03

RPEL repeat; The RPEL repeat is named after four conserved amino acids it contains. The RPEL motif binds to actin.


Pssm-ID: 460677  Cd Length: 24  Bit Score: 36.48  E-value: 1.01e-03
                          10        20
                  ....*....|....*....|..
gi 701462854  423 SLAIKLSNRPSKRELEEKNILP 444
Cdd:pfam02755   1 SLERKLSHRPTREELVERNILP 22
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
422-446 1.04e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 36.69  E-value: 1.04e-03
                           10        20
                   ....*....|....*....|....*
gi 701462854   422 DSLAIKLSNRPSKRELEEKNILPRQ 446
Cdd:smart00707   1 DVLNRKLSQRPTREELEERNILKEL 25
RPEL smart00707
Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;
140-161 3.45e-03

Repeat in Drosophila CG10860, human KIAA0680 and C. elegans F26H9.2;


Pssm-ID: 128947  Cd Length: 26  Bit Score: 35.15  E-value: 3.45e-03
                           10        20
                   ....*....|....*....|..
gi 701462854   140 LERKISMRQSREELIKRGVLKE 161
Cdd:smart00707   3 LNRKLSQRPTREELEERNILKE 24
Atrophin-1 pfam03154
Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian ...
 173-383 3.88e-03

Atrophin-1 family; Atrophin-1 is the protein product of the dentatorubral-pallidoluysian atrophy (DRPLA) gene. DRPLA OMIM:125370 is a progressive neurodegenerative disorder. It is caused by the expansion of a CAG repeat in the DRPLA gene on chromosome 12p. This results in an extended polyglutamine region in atrophin-1, that is thought to confer toxicity to the protein, possibly through altering its interactions with other proteins. The expansion of a CAG repeat is also the underlying defect in six other neurodegenerative disorders, including Huntington's disease. One interaction of expanded polyglutamine repeats that is thought to be pathogenic is that with the short glutamine repeat in the transcriptional coactivator CREB binding protein, CBP. This interaction draws CBP away from its usual nuclear location to the expanded polyglutamine repeat protein aggregates that are characteriztic of the polyglutamine neurodegenerative disorders. This interferes with CBP-mediated transcription and causes cytotoxicity.


Pssm-ID: 460830 [Multi-domain]  Cd Length: 991  Bit Score: 40.14  E-value: 3.88e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  173 NEDDSLENGQSLSSSQLSLPALSEMEPVPMPRDPCSYEVLQASDimdGPDPGAPVKLPC-------LPVKLSPPLPPKKV 245
Cdd:pfam03154 154 NESDSDSSAQQQILQTQPPVLQAQSGAASPPSPPPPGTTQAATA---GPTPSAPSVPPQgspatsqPPNQTQSTAAPHTL 230

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  246 LICMPVGGPE-----------LTLASYAAQKSSQQAVAQHHHTVLPSqMQHQLQYG-SHGQHlPSSTGTLPMHPSGCRMI 313
Cdd:pfam03154 231 IQQTPTLHPQrlpsphpplqpMTQPPPPSQVSPQPLPQPSLHGQMPP-MPHSLQTGpSHMQH-PVPPQPFPLTPQSSQSQ 308

                         170       180       190       200       210       220       230
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 701462854  314 DELNKTLAMTMQrlESSEQRVPCSTSYHSSGLHSSDGITKAGPMGLPEIRQVPTVVIECDDNKENVPHEP 383
Cdd:pfam03154 309 VPPGPSPAAPGQ--SQQRIHTPPSQSQLQSQQPPREQPLPPAPLSMPHIKPPPTTPIPQLPNPQSHKHPP 376
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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