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Conserved domains on  [gi|669033270|ref|NP_001288153|]
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calcium and integrin-binding family member 2 isoform 4 [Homo sapiens]

Protein Classification

EF-hand domain-containing protein( domain architecture ID 12144783)

EF-hand (EFh) domain-containing protein may be involved in binding intracellular calcium and in calcium signal transduction

CATH:  1.10.238.10
Gene Ontology:  GO:0005509
PubMed:  2479149|10191494
SCOP:  3001983

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-178 2.72e-09

EF-hand domain pair;


:

Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.49  E-value: 2.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 669033270  112 KANYAFKIYDFNTDNFICKEDLELTLARLTKS-ELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 178
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGePLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-178 2.72e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.49  E-value: 2.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 669033270  112 KANYAFKIYDFNTDNFICKEDLELTLARLTKS-ELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 178
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGePLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 86-178 9.87e-09

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 52.07  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  86 DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKsELDEEEVvlvcDKVIEEADLDG 165
Cdd:PTZ00184  59 DGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE-KLTDEEV----DEMIREADVDG 133

                         90
                 ....*....|...
gi 669033270 166 DGKLGFADFEDMI 178
Cdd:PTZ00184 134 DGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 112-179 8.94e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 47.16  E-value: 8.94e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 669033270 112 KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEevvlvCDKVIEEADLDGDGKLGFADFEDMIA 179
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
77-174 6.08e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.32  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  77 ERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEltlARLTKSELDEEEVvlvcDK 156
Cdd:COG5126   36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                         90
                 ....*....|....*...
gi 669033270 157 VIEEADLDGDGKLGFADF 174
Cdd:COG5126  108 LFARLDTDGDGKISFEEF 125
 
Name Accession Description Interval E-value
EF-hand_7 pfam13499
EF-hand domain pair;
112-178 2.72e-09

EF-hand domain pair;


Pssm-ID: 463900 [Multi-domain]  Cd Length: 67  Bit Score: 51.49  E-value: 2.72e-09
                          10        20        30        40        50        60
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 669033270  112 KANYAFKIYDFNTDNFICKEDLELTLARLTKS-ELDEEEVvlvcDKVIEEADLDGDGKLGFADFEDMI 178
Cdd:pfam13499   3 KLKEAFKLLDSDGDGYLDVEELKKLLRKLEEGePLSDEEV----EELFKEFDLDKDGRISFEEFLELY 66
PTZ00184 PTZ00184
calmodulin; Provisional
 86-178 9.87e-09

calmodulin; Provisional


Pssm-ID: 185504 [Multi-domain]  Cd Length: 149  Bit Score: 52.07  E-value: 9.87e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  86 DGEGNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKsELDEEEVvlvcDKVIEEADLDG 165
Cdd:PTZ00184  59 DGNGTIDFPEFLTLMARKMKDTDSEEEIKEAFKVFDRDGNGFISAAELRHVMTNLGE-KLTDEEV----DEMIREADVDG 133

                         90
                 ....*....|...
gi 669033270 166 DGKLGFADFEDMI 178
Cdd:PTZ00184 134 DGQINYEEFVKMM 146
EFh cd00051
EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal ...
 112-179 8.94e-08

EF-hand, calcium binding motif; A diverse superfamily of calcium sensors and calcium signal modulators; most examples in this alignment model have 2 active canonical EF hands. Ca2+ binding induces a conformational change in the EF-hand motif, leading to the activation or inactivation of target proteins. EF-hands tend to occur in pairs or higher copy numbers.


Pssm-ID: 238008 [Multi-domain]  Cd Length: 63  Bit Score: 47.16  E-value: 8.94e-08
                         10        20        30        40        50        60
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 669033270 112 KANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEEevvlvCDKVIEEADLDGDGKLGFADFEDMIA 179
Cdd:cd00051    1 ELREAFRLFDKDGDGTISADELKAALKSLGEGLSEEE-----IDEMIREVDKDGDGKIDFEEFLELMA 63
PTZ00183 PTZ00183
centrin; Provisional
 73-182 4.09e-05

centrin; Provisional


Pssm-ID: 185503 [Multi-domain]  Cd Length: 158  Bit Score: 41.98  E-value: 4.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  73 NPFKE---RIVAAFSEDGEGNLTFNDFVDMFSV-LCESAPRElKANYAFKIYDFNTDNFICKEDLELTLARLTKSELDEE 148
Cdd:PTZ00183  49 EPKKEeikQMIADVDKDGSGKIDFEEFLDIMTKkLGERDPRE-EILKAFRLFDDDKTGKISLKNLKRVAKELGETITDEE 127

                         90       100       110
                 ....*....|....*....|....*....|....
gi 669033270 149 evvlvCDKVIEEADLDGDGKLGFADFEDMIAKAP 182
Cdd:PTZ00183 128 -----LQEMIDEADRNGDGEISEEEFYRIMKKTN 156
FRQ1 COG5126
Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];
77-174 6.08e-05

Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms];


Pssm-ID: 444056 [Multi-domain]  Cd Length: 137  Bit Score: 41.32  E-value: 6.08e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  77 ERIVAAFSEDGEGNLTFNDFVDMFSVLCESAPRElKANYAFKIYDFNTDNFICKEDLEltlARLTKSELDEEEVvlvcDK 156
Cdd:COG5126   36 ATLFSEADTDGDGRISREEFVAGMESLFEATVEP-FARAAFDLLDTDGDGKISADEFR---RLLTALGVSEEEA----DE 107

                         90
                 ....*....|....*...
gi 669033270 157 VIEEADLDGDGKLGFADF 174
Cdd:COG5126  108 LFARLDTDGDGKISFEEF 125
EFh_calglandulin_like cd16252
EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The ...
 89-180 3.04e-04

EF-hand, calcium binding motif, found in uncharacterized calglandulin-like proteins; The family corresponds to a group of uncharacterized calglandulin-like proteins. Although their biological function remain unclear, they show high sequence similarity with human calglandulin-like protein GAGLP, which is an ortholog of calglandulin from the venom glands of Bothrops insularis snake. Both GAGLP and calglandulin are putative Ca2+-binding proteins with four EF-hand motifs. However, members in this family contain only three EF-hand motifs. In this point, they may belong to the parvalbumin-like EF-hand family, which is characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix).


Pssm-ID: 319995 [Multi-domain]  Cd Length: 106  Bit Score: 38.67  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  89 GNLTFNDFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKS----ELDEEEVvlvcDKVIEEADLD 164
Cdd:cd16252   15 GSFNYSKFFEYMQKFQTSEQQEEAIRKAFQMLDKDKSGFIEWNEIKYILSTVPSSmpvaPLSDEEA----EAMIQAADTD 90

                         90
                 ....*....|....*.
gi 669033270 165 GDGKLGFADFEDMIAK 180
Cdd:cd16252   91 GDGRIDFQEFSDMVKK 106
EFh_parvalbumin_like cd16251
EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes ...
 77-179 9.64e-03

EF-hand, calcium binding motif, found in parvalbumin-like EF-hand family; The family includes alpha- and beta-parvalbumins, and a group of uncharacterized calglandulin-like proteins. Parvalbumins are small, acidic, cytosolic EF-hand-containing Ca2+-buffer and Ca2+ transporter/shuttle proteins belonging to EF-hand superfamily. They are expressed by vertebrates in fast-twitch muscle cells, specific neurons of the central and peripheral nervous system, sensory cells of the mammalian auditory organ (Corti's cell), and some other cells, and characterized by the presence of three consecutive EF-hand motifs (helix-loop-helix) called AB, CD, and EF, but only CD and EF can chelate metal ions, such as Ca2+ and Mg2+. Thus, they may play an additional role in Mg2+ handling. Moreover, parvalbumins represent one of the major animal allergens. In metal-bound states, parvalbumins possess a rigid and stable tertiary structure and display strong allergenicity. In contrast, the metal-free parvalbumins are intrinsically disordered, and the loss of metal ions results in a conformational change that decreases their IgE binding capacity. Furthermore, parvalbumins have been widely used as a neuronal marker for a variety of functional brain systems. They also function as a Ca2+ shuttle transporting Ca2+ from troponin-C (TnC) to the sarcoplasmic reticulum (SR) Ca2+ pump during muscle relaxation. Thus they may facilitate myocardial relaxation and play important roles in cardiac diastolic dysfunction. Parvalbumins consists of alpha- and beta- sublineages, which can be distinguished on the basis of isoelectric point (pI > 5 for alpha; pI


Pssm-ID: 319994 [Multi-domain]  Cd Length: 101  Bit Score: 34.43  E-value: 9.64e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 669033270  77 ERIVAAFSEDGegnlTFNdFVDMFSVLCESAPRELKANYAFKIYDFNTDNFICKEDLELTLARLTKS--ELDEEEVvlvc 154
Cdd:cd16251    5 EKAPSAFRAHG----SFN-YKKFFEHVGLKQKSEDQIKKVFQILDKDKSGFIEEEELKYILKGFSIAgrDLTDEET---- 75

                         90       100
                 ....*....|....*....|....*
gi 669033270 155 DKVIEEADLDGDGKLGFADFEDMIA 179
Cdd:cd16251   76 KALLAAGDTDGDGKIGVEEFATLVA 100
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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