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Conserved domains on  [gi|665410148|ref|NP_001287003|]
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metal response element-binding transcription Factor-1, isoform G [Drosophila melanogaster]

Protein Classification

C2H2-type zinc finger protein( domain architecture ID 11472214)

Cys2His2 (C2H2)-type zinc finger protein may be involved in transcriptional regulation

CATH:  3.30.160.60
Gene Ontology:  GO:0008270|GO:0003677
PubMed:  11361095|22803940
SCOP:  4003583

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
6-83 2.51e-06

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665410148   6 QERPYKCPEddCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQT 83
Cdd:COG5048   30 APRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
PRK14954 super family cl33039
DNA polymerase III subunits gamma and tau; Provisional
 427-505 5.41e-03

DNA polymerase III subunits gamma and tau; Provisional


The actual alignment was detected with superfamily member PRK14954:

Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.54  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410148 427 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 503
Cdd:PRK14954 380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                 ..
gi 665410148 504 EV 505
Cdd:PRK14954 460 GV 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
6-83 2.51e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665410148   6 QERPYKCPEddCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQT 83
Cdd:COG5048   30 APRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
26-53 2.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.92e-05
                          10        20
                  ....*....|....*....|....*...
gi 665410148   26 HLKTHRRTHTGEKPYPCQEdsCQKSFST 53
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 427-505 5.41e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.54  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410148 427 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 503
Cdd:PRK14954 380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                 ..
gi 665410148 504 EV 505
Cdd:PRK14954 460 GV 461
 
Name Accession Description Interval E-value
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
6-83 2.51e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 50.08  E-value: 2.51e-06
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 665410148   6 QERPYKCPEddCGKAFTASHHLKTHRRTHTGEKPYPCQEDSCQKSFSTSHSLKSHKKTHQRQLQNKGRKKRPLKTQQT 83
Cdd:COG5048   30 APRPDSCPN--CTDSFSRLEHLTRHIRSHTGEKPSQCSYSGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKA 105
zf-H2C2_2 pfam13465
Zinc-finger double domain;
26-53 2.92e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 40.82  E-value: 2.92e-05
                          10        20
                  ....*....|....*....|....*...
gi 665410148   26 HLKTHRRTHTGEKPYPCQEdsCQKSFST 53
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPE--CGKSFKS 26
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 10-34 8.01e-04

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 36.89  E-value: 8.01e-04
                          10        20
                  ....*....|....*....|....*
gi 665410148   10 YKCPedDCGKAFTASHHLKTHRRTH 34
Cdd:pfam00096   1 YKCP--DCGKSFSRKSNLKRHLRTH 23
zf-H2C2_2 pfam13465
Zinc-finger double domain;
1-22 1.16e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.16e-03
                          10        20
                  ....*....|....*....|..
gi 665410148    1 MRTHTQERPYKCPEddCGKAFT 22
Cdd:pfam13465   6 MRTHTGEKPYKCPE--CGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 7-62 1.41e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.24  E-value: 1.41e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 665410148   7 ERPYKCPEDDCGKAFTASHHLKTHR-------RTH------------TGEKPYPCQedSCQKSFSTSHSLKSHKK 62
Cdd:COG5189  347 GKPYKCPVEGCNKKYKNQNGLKYHMlhghqnqKLHenpspekmnifsAKDKPYRCE--VCDKRYKNLNGLKYHRK 419
PRK14954 PRK14954
DNA polymerase III subunits gamma and tau; Provisional
 427-505 5.41e-03

DNA polymerase III subunits gamma and tau; Provisional


Pssm-ID: 184918 [Multi-domain]  Cd Length: 620  Bit Score: 39.54  E-value: 5.41e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 665410148 427 VKPAPSGGGCC---GEPKAPKPVNAGCGCARPSAPSSGGCCGSGVASTPKPTGGCCSGNQKPAPTATAASSPSCCCSGKG 503
Cdd:PRK14954 380 VAPSPAGSPDVkkkAPEPDLPQPDRHPGPAKPEAPGARPAELPSPASAPTPEQQPPVARSAPLPPSPQASAPRNVASGKP 459


                 ..
gi 665410148 504 EV 505
Cdd:PRK14954 460 GV 461
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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