|
Name |
Accession |
Description |
Interval |
E-value |
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
319-820 |
3.20e-88 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 293.34 E-value: 3.20e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 319 LPSKVRDLYAQFkGIEKLYEWQHTCLTlNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKdVLMILPY-------- 390
Cdd:COG1204 7 PLEKVIEFLKER-GIEELYPPQAEALE-AGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGK-ALYIVPLralaseky 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 391 -------------VAIV--------------------QEKL----------------------HMIGEGSRGATLEMTLA 415
Cdd:COG1204 84 refkrdfeelgikVGVStgdydsddewlgrydilvatPEKLdsllrngpswlrdvdlvvvdeaHLIDDESRGPTLEVLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 416 KILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYevdskaengmtfsrllnykYSDTLKKM 495
Cdd:COG1204 164 RLRRLNPEAQIVALSATIGNAEEIAEWLDAELVKSDWRPVPLNEGVLYDGVLR-------------------FDDGSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 496 DpDHLVALVTEVIP-NYSCLVFCPSKKNCENVAEMICKFLsKEYLKHKEKEKC-EVIKNLKNIGNGN-LCPVLKRTIPFG 572
Cdd:COG1204 225 K-DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEThTNEKLADCLEKG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 573 VAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPY-VAKEFLKRNQYKQMIGRAGRAGIDTIGE 651
Cdd:COG1204 303 VAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAGRPGYDPYGE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 652 SILIlqEKDKQQVLELITKPL----ENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQkvllKEKS 727
Cdd:COG1204 383 AILV--AKSSDEADELFERYIlgepEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQY----DKGD 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 728 LWEITVESLRYLTEKGLLQKDTIYkseeevqynFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTT 807
Cdd:COG1204 455 LEEVVDDALEFLLENGFIEEDGDR---------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLGLLHLILILR 525
|
570
....*....|...
gi 1844084119 808 pydlvsqcnpDWM 820
Cdd:COG1204 526 ----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
318-999 |
3.55e-76 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 266.05 E-value: 3.55e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 318 SLPSKVRDLYAQfKGIEKLYEWQHTCLTlNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKdVLMILPYVAIVQEK 397
Cdd:PRK02362 7 PLPEGVIEFYEA-EGIEELYPPQAEAVE-AGLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGK-ALYIVPLRALASEK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 --------------------------------------------------------------LHMIGEGSRGATLEMTLA 415
Cdd:PRK02362 84 feeferfeelgvrvgistgdydsrdewlgdndiivatsekvdsllrngapwldditcvvvdeVHLIDSANRGPTLEVTLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 416 KILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAEngmtfsrllnykysdtLKKM 495
Cdd:PRK02362 164 KLRRLNPDLQVVALSATIGNADELADWLDAELVDSEWRPIDLREGVFYGGAIHFDDSQRE----------------VEVP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 496 DPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVA 574
Cdd:PRK02362 228 SKDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIREVSDTETSKDLADCVAKGAA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 575 YHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILR-----------APYVAKEflkrnqYKQMIGRAGR 643
Cdd:PRK02362 308 FHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQPIPVLE------YHQMAGRAGR 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 644 AGIDTIGESILIlqEKDKQQVLEL----ITKPLENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQ 719
Cdd:PRK02362 382 PGLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE--PALRTHVLSTIASGFARTRDGLLEFLEATFYATQT 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 720 KvllKEKSLWEITVESLRYLTEKGLLQKDtiyksEEEVqynfHITKLGRasfkgTIDLAYCDILY-RDLKKGLEGLVLES 798
Cdd:PRK02362 458 D---DTGRLERVVDDVLDFLERNGMIEED-----GETL----EATELGH-----LVSRLYIDPLSaAEIIDGLEAAKKPT 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 799 ---LLHLIYLTtpydlvsqcnPD-WMIYFRqfsqlSPAEQNVAAILGVSES-FIGKKASgqaigkkVDKNVVNRLYLSFV 873
Cdd:PRK02362 521 dlgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS-------EFEDDEFEDFLSAV 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 874 LYTLLKETNIWTVSE-----KFNMPRGYIQN-------LLTGTASFSScvlhfceELEEFWVYRAllVELTKKLTYCVKA 941
Cdd:PRK02362 579 KTALLLEDWIDEVDEeriteRYGVGPGDIRGkvetaewLLHAAERLAS-------ELDLDLARAA--RELEKRVEYGVRE 649
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 1844084119 942 ELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTidhLSRRQAKQIVSSAK 999
Cdd:PRK02362 650 ELLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
319-454 |
1.19e-64 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 216.70 E-value: 1.19e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 319 LPSKVRDLYAQfKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEK- 397
Cdd:cd18026 1 LPDAVREAYAK-KGIKKLYDWQKECLSLPGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKKALFVLPYVSIVQEKv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 -----------------------------------------------------------------LHMIGEGSRGATLEM 412
Cdd:cd18026 80 dalsplfeelgfrvegyagnkgrsppkrrkslsvavctiekanslvnslieegrldelglvvvdeLHMLGDGHRGALLEL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1844084119 413 TLAKILYTSK-TTQIIGMSATLNNVEDLQKFLQAEYYTSQFRP 454
Cdd:cd18026 160 LLTKLLYAAQkNIQIVGMSATLPNLEELASWLRAELYTTNFRP 202
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
650-746 |
2.88e-30 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 114.95 E-value: 2.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 650 GESILILQEKDKQQVLELITKPLENCYSHLVQEfTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSlw 729
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 1844084119 730 eiTVESLRYLTEKGLLQ 746
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
567-645 |
1.28e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.16 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 567 RTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKEflkrnQYKQMIGRAGRAG 645
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWSPA-----SYIQRIGRAGRAG 82
|
|
| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
946-999 |
2.72e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 37.08 E-value: 2.72e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1844084119 946 LMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDhLSRRQAKQIVSSAK 999
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| BRR2 |
COG1204 |
Replicative superfamily II helicase [Replication, recombination and repair]; |
319-820 |
3.20e-88 |
|
Replicative superfamily II helicase [Replication, recombination and repair];
Pssm-ID: 440817 [Multi-domain] Cd Length: 529 Bit Score: 293.34 E-value: 3.20e-88
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 319 LPSKVRDLYAQFkGIEKLYEWQHTCLTlNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKdVLMILPY-------- 390
Cdd:COG1204 7 PLEKVIEFLKER-GIEELYPPQAEALE-AGLLEGKNLVVSAPTASGKTLIAELAILKALLNGGK-ALYIVPLralaseky 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 391 -------------VAIV--------------------QEKL----------------------HMIGEGSRGATLEMTLA 415
Cdd:COG1204 84 refkrdfeelgikVGVStgdydsddewlgrydilvatPEKLdsllrngpswlrdvdlvvvdeaHLIDDESRGPTLEVLLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 416 KILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYevdskaengmtfsrllnykYSDTLKKM 495
Cdd:COG1204 164 RLRRLNPEAQIVALSATIGNAEEIAEWLDAELVKSDWRPVPLNEGVLYDGVLR-------------------FDDGSRRS 224
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 496 DpDHLVALVTEVIP-NYSCLVFCPSKKNCENVAEMICKFLsKEYLKHKEKEKC-EVIKNLKNIGNGN-LCPVLKRTIPFG 572
Cdd:COG1204 225 K-DPTLALALDLLEeGGQVLVFVSSRRDAESLAKKLADEL-KRRLTPEEREELeELAEELLEVSEEThTNEKLADCLEKG 302
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 573 VAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPY-VAKEFLKRNQYKQMIGRAGRAGIDTIGE 651
Cdd:COG1204 303 VAFHHAGLPSELRRLVEDAFREGLIKVLVATPTLAAGVNLPARRVIIRDTKrGGMVPIPVLEFKQMAGRAGRPGYDPYGE 382
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 652 SILIlqEKDKQQVLELITKPL----ENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQkvllKEKS 727
Cdd:COG1204 383 AILV--AKSSDEADELFERYIlgepEPIRSKLANE--SALRTHLLALIASGFANSREELLDFLENTFYAYQY----DKGD 454
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 728 LWEITVESLRYLTEKGLLQKDTIYkseeevqynFHITKLGRASFKGTIDLAYCDILYRDLKKGLEGLVLESLLHLIYLTT 807
Cdd:COG1204 455 LEEVVDDALEFLLENGFIEEDGDR---------LRATKLGKLVSRLYIDPLTAAELVDGLRKADEEFTDLGLLHLILILR 525
|
570
....*....|...
gi 1844084119 808 pydlvsqcnpDWM 820
Cdd:COG1204 526 ----------DWI 528
|
|
| PRK02362 |
PRK02362 |
ATP-dependent DNA helicase; |
318-999 |
3.55e-76 |
|
ATP-dependent DNA helicase;
Pssm-ID: 235032 [Multi-domain] Cd Length: 737 Bit Score: 266.05 E-value: 3.55e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 318 SLPSKVRDLYAQfKGIEKLYEWQHTCLTlNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKdVLMILPYVAIVQEK 397
Cdd:PRK02362 7 PLPEGVIEFYEA-EGIEELYPPQAEAVE-AGLLDGKNLLAAIPTASGKTLIAELAMLKAIARGGK-ALYIVPLRALASEK 83
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 --------------------------------------------------------------LHMIGEGSRGATLEMTLA 415
Cdd:PRK02362 84 feeferfeelgvrvgistgdydsrdewlgdndiivatsekvdsllrngapwldditcvvvdeVHLIDSANRGPTLEVTLA 163
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 416 KILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAEngmtfsrllnykysdtLKKM 495
Cdd:PRK02362 164 KLRRLNPDLQVVALSATIGNADELADWLDAELVDSEWRPIDLREGVFYGGAIHFDDSQRE----------------VEVP 227
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 496 DPDHLVALVTEVI-PNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLKNIGNGNLCPVLKRTIPFGVA 574
Cdd:PRK02362 228 SKDDTLNLVLDTLeEGGQCLVFVSSRRNAEGFAKRAASALKKTLTAAERAELAELAEEIREVSDTETSKDLADCVAKGAA 307
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 575 YHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILR-----------APYVAKEflkrnqYKQMIGRAGR 643
Cdd:PRK02362 308 FHHAGLSREHRELVEDAFRDRLIKVISSTPTLAAGLNLPARRVIIRdyrrydggagmQPIPVLE------YHQMAGRAGR 381
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 644 AGIDTIGESILIlqEKDKQQVLEL----ITKPLENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQ 719
Cdd:PRK02362 382 PGLDPYGEAVLL--AKSYDELDELferyIWADPEDVRSKLATE--PALRTHVLSTIASGFARTRDGLLEFLEATFYATQT 457
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 720 KvllKEKSLWEITVESLRYLTEKGLLQKDtiyksEEEVqynfHITKLGRasfkgTIDLAYCDILY-RDLKKGLEGLVLES 798
Cdd:PRK02362 458 D---DTGRLERVVDDVLDFLERNGMIEED-----GETL----EATELGH-----LVSRLYIDPLSaAEIIDGLEAAKKPT 520
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 799 ---LLHLIYLTtpydlvsqcnPD-WMIYFRqfsqlSPAEQNVAAILGVSES-FIGKKASgqaigkkVDKNVVNRLYLSFV 873
Cdd:PRK02362 521 dlgLLHLVCST----------PDmYELYLR-----SGDYEWLNEYLYEHEDeLLGDVPS-------EFEDDEFEDFLSAV 578
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 874 LYTLLKETNIWTVSE-----KFNMPRGYIQN-------LLTGTASFSScvlhfceELEEFWVYRAllVELTKKLTYCVKA 941
Cdd:PRK02362 579 KTALLLEDWIDEVDEeriteRYGVGPGDIRGkvetaewLLHAAERLAS-------ELDLDLARAA--RELEKRVEYGVRE 649
|
730 740 750 760 770
....*....|....*....|....*....|....*....|....*....|....*...
gi 1844084119 942 ELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTidhLSRRQAKQIVSSAK 999
Cdd:PRK02362 650 ELLDLVGLRGVGRVRARRLYNAGIESRADLRAADKSVVLAI---LGEKIAENILEQAG 704
|
|
| DEXHc_POLQ-like |
cd18026 |
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in ... |
319-454 |
1.19e-64 |
|
DEXH-box helicase domain of DNA polymerase theta; DNA polymerase theta (POLQ) is important in the repair of genomic double-strand breaks (DSBs). POLQ contains an N-terminal type II DEAD box helicase domain which contains the ATP-binding region.
Pssm-ID: 350784 [Multi-domain] Cd Length: 202 Bit Score: 216.70 E-value: 1.19e-64
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 319 LPSKVRDLYAQfKGIEKLYEWQHTCLTLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEK- 397
Cdd:cd18026 1 LPDAVREAYAK-KGIKKLYDWQKECLSLPGLLEGRNLVYSLPTSGGKTLVAEILMLKRLLERRKKALFVLPYVSIVQEKv 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 -----------------------------------------------------------------LHMIGEGSRGATLEM 412
Cdd:cd18026 80 dalsplfeelgfrvegyagnkgrsppkrrkslsvavctiekanslvnslieegrldelglvvvdeLHMLGDGHRGALLEL 159
|
170 180 190 200
....*....|....*....|....*....|....*....|...
gi 1844084119 413 TLAKILYTSK-TTQIIGMSATLNNVEDLQKFLQAEYYTSQFRP 454
Cdd:cd18026 160 LLTKLLYAAQkNIQIVGMSATLPNLEELASWLRAELYTTNFRP 202
|
|
| PRK00254 |
PRK00254 |
ski2-like helicase; Provisional |
331-981 |
9.96e-51 |
|
ski2-like helicase; Provisional
Pssm-ID: 234702 [Multi-domain] Cd Length: 720 Bit Score: 191.95 E-value: 9.96e-51
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 331 KGIEKLYEWQHTCLTlNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEK------------- 397
Cdd:PRK00254 19 RGIEELYPPQAEALK-SGVLEGKNLVLAIPTASGKTLVAEIVMVNKLLREGGKAVYLVPLKALAEEKyrefkdweklglr 97
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 -------------------------------------------------LHMIGEGSRGATLEMTLAKILytsKTTQIIG 428
Cdd:PRK00254 98 vamttgdydstdewlgkydiiiataekfdsllrhgsswikdvklvvadeIHLIGSYDRGATLEMILTHML---GRAQILG 174
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 429 MSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLLNYkysDTLKKmdpdhlvalvtevi 508
Cdd:PRK00254 175 LSATVGNAEELAEWLNAELVVSDWRPVKLRKGVFYQGFLFWEDGKIERFPNSWESLVY---DAVKK-------------- 237
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 509 pNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKEKEKCEVIKNLK-NIGNGNLcpvlKRTIPFGVAYHHSGLTSDERKL 587
Cdd:PRK00254 238 -GKGALVFVNTRRSAEKEALELAKKIKRFLTKPELRALKELADSLEeNPTNEKL----KKALRGGVAFHHAGLGRTERVL 312
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 588 LEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVAKEF----LKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQ 663
Cdd:PRK00254 313 IEDAFREGLIKVITATPTLSAGINLPAFRVIIRDTKRYSNFgwedIPVLEIQQMMGRAGRPKYDEVGEAIIVATTEEPSK 392
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 664 VLE--LITKPlENCYSHLVQEftKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQkvllKEKSLWEITVESLRYLte 741
Cdd:PRK00254 393 LMEryIFGKP-EKLFSMLSNE--SAFRSQVLALITNFGVSNFKELVNFLERTFYAHQR----KDLYSLEEKAKEIVYF-- 463
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 742 kgLLQKDTIyksEEEVQYNFHITKLGRASFKGTIDlaycDILYRDLKKGLEGLVLE----SLLHLIYLT---TPYDLVSQ 814
Cdd:PRK00254 464 --LLENEFI---DIDLEDRFIPLPLGIRTSQLYID----PLTAKKFKDAFPKIEKNpnplGIFQLIASTpdmTPLNYSRK 534
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 815 CNPDWMIYFRQFsqlspaEQNVAAILGVSESFIGKKASGQAIGKKvdknvvnrlylsfVLYTLLKETNIWTVSEKFNMPR 894
Cdd:PRK00254 535 EMEDLLDEAYEM------EDRLYFNIPYWEDYKFQKFLRAFKTAK-------------VLLDWINEVPEGEIVETYNIDP 595
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 895 GYIQNLLtgtasfsscvlhfceELEEFWVYRalLVELTK-----------------KLTYCVKAELIPLMEVTGVLEGRA 957
Cdd:PRK00254 596 GDLYRIL---------------ELADWLMYS--LIELYKlfepkqevldyletlhlRVKHGVREELLELMRLPMIGRKRA 658
|
730 740
....*....|....*....|....
gi 1844084119 958 KQLYSAGYKSLMHLANANPEVLVR 981
Cdd:PRK00254 659 RALYNAGFRSIEDIVNAKPSELLK 682
|
|
| PRK01172 |
PRK01172 |
ATP-dependent DNA helicase; |
339-1005 |
5.87e-47 |
|
ATP-dependent DNA helicase;
Pssm-ID: 100801 [Multi-domain] Cd Length: 674 Bit Score: 179.69 E-value: 5.87e-47
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 339 WQHTCLTLNSVQERKNLIYSLPTSGGKTLVA-----------------------------EILMLQEL------------ 377
Cdd:PRK01172 24 YDHQRMAIEQLRKGENVIVSVPTAAGKTLIAysaiyetflaglksiyivplrslamekyeELSRLRSLgmrvkisigdyd 103
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 378 ----LCCRKDVLMIL-----------PYV-----AIVQEKLHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVE 437
Cdd:PRK01172 104 dppdFIKRYDVVILTsekadslihhdPYIindvgLIVADEIHIIGDEDRGPTLETVLSSARYVNPDARILALSATVSNAN 183
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 438 DLQKFLQAEYYTSQFRPVELKEYLKINDTIYeVDSKAENGMTFSRLLNYKYSDtlkkmdpdhlvalvtevipNYSCLVFC 517
Cdd:PRK01172 184 ELAQWLNASLIKSNFRPVPLKLGILYRKRLI-LDGYERSQVDINSLIKETVND-------------------GGQVLVFV 243
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 518 PSKKNCENVAEMICKFLSKeylkhkekekcevIKNLK-NIGNGNLCP-VLKRTIPFGVAYHHSGLTSDERKLLEEAYSTG 595
Cdd:PRK01172 244 SSRKNAEDYAEMLIQHFPE-------------FNDFKvSSENNNVYDdSLNEMLPHGVAFHHAGLSNEQRRFIEEMFRNR 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 596 VLCLFTCTSTLAAGVNLPARRVIL----RAPYVAKEFLKRNQYKQMIGRAGRAGIDTIGESILILQEKDKQQVL-ELITK 670
Cdd:PRK01172 311 YIKVIVATPTLAAGVNLPARLVIVrditRYGNGGIRYLSNMEIKQMIGRAGRPGYDQYGIGYIYAASPASYDAAkKYLSG 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 671 PLENCYSHLVQEFTKGIQTlfLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSLweitVESLRYLTEKGLLQKDTI 750
Cdd:PRK01172 391 EPEPVISYMGSQRKVRFNT--LAAISMGLASSMEDLILFYNETLMAIQNGVDEIDYYI----ESSLKFLKENGFIKGDVT 464
|
490 500 510 520 530 540 550 560
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 751 YKSeeevqynfhiTKLGRAsfkgTIDLaYCDIlyrdlkkgleglvlESLLHLI-YLTTPYDLvsqcnpDWMIYFRQFS-Q 828
Cdd:PRK01172 465 LRA----------TRLGKL----TSDL-YIDP--------------ESALILKsAFDHDYDE------DLALYYISLCrE 509
|
570 580 590 600 610 620 630 640
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 829 LSPAE-QNVAAILGVSESfIGkkasgqaigkKVDKNvVNRLYLSFVLYTLLKETNIWTVSEKFNMPRGYIQNLLTGTASF 907
Cdd:PRK01172 510 IIPANtRDDYYAMEFLED-IG----------VIDGD-ISAAKTAMVLRGWISEASMQKITDTYGIAPGDVQARASSADWI 577
|
650 660 670 680 690 700 710 720
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 908 SSCVLHFCEeleefwVY----RALLVELTKKLTYCVKAELIPLMEVTGVLEGRAKQLYSAGYKSLMHLANANPEvLVRTI 983
Cdd:PRK01172 578 SYSLARLSS------IYkpemRRKLEILNIRIKEGIREDLIDLVLIPKVGRVRARRLYDAGFKTVDDIARSSPE-RIKKI 650
|
730 740
....*....|....*....|..
gi 1844084119 984 DHLSRRQAKQIVSSAKMLLHEK 1005
Cdd:PRK01172 651 YGFSDTLANAIVNRAMKISSMY 672
|
|
| SF2_C_Ski2 |
cd18795 |
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an ... |
453-655 |
1.36e-42 |
|
C-terminal helicase domain of the Ski2 family helicases; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. This family includes spliceosomal Brr2 RNA helicase, ASCC3 (involved in the repair of N-alkylated nucleotides), Mtr4 (involved in processing of structured RNAs), DDX60 (involved in viral RNA degradation), and other proteins. Ski2-like RNA helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350182 [Multi-domain] Cd Length: 154 Bit Score: 152.32 E-value: 1.36e-42
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 453 RPVELKEYLKIndtiyevdskaengmtFSRLLNYKYSDTLKKMDPDHLVALVTEVIPNY-SCLVFCPSKKNCENVAEMIc 531
Cdd:cd18795 1 RPVPLEEYVLG----------------FNGLGIKLRVDVMNKFDSDIIVLLKIETVSEGkPVLVFCSSRKECEKTAKDL- 63
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 532 kflskeylkhkekekceviknlknigngnlcpvlkrtipFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVN 611
Cdd:cd18795 64 ---------------------------------------AGIAFHHAGLTREDRELVEELFREGLIKVLVATSTLAAGVN 104
|
170 180 190 200
....*....|....*....|....*....|....*....|....*...
gi 1844084119 612 LPARRVILRAPYVAK----EFLKRNQYKQMIGRAGRAGIDTIGESILI 655
Cdd:cd18795 105 LPARTVIIKGTQRYDgkgyRELSPLEYLQMIGRAGRPGFDTRGEAIIM 152
|
|
| HTH_61 |
pfam20470 |
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA ... |
650-746 |
2.88e-30 |
|
Helix-turn-helix domain; This entry represents a presumed helix-turn-helix domain found in DNA polymerase theta.
Pssm-ID: 466619 [Multi-domain] Cd Length: 92 Bit Score: 114.95 E-value: 2.88e-30
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 650 GESILILQEKDKQQVLELITKPLENCYSHLVQEfTKGIQTLFLSLIGLKIATNLDDIYHFMNGTFFGVQQKVLLKEKSlw 729
Cdd:pfam20470 1 GESILICKEKDLEKVAELLRAELPPVYSCLLPE-KRGIKRALLEIIALGLATSPEDVDEYMSCTLLSVQQKELDVEKS-- 77
|
90
....*....|....*..
gi 1844084119 730 eiTVESLRYLTEKGLLQ 746
Cdd:pfam20470 78 --IESSLEELVENGLIT 92
|
|
| Dob10 |
COG4581 |
Superfamily II RNA helicase [Replication, recombination and repair]; |
320-673 |
2.53e-27 |
|
Superfamily II RNA helicase [Replication, recombination and repair];
Pssm-ID: 443638 [Multi-domain] Cd Length: 751 Bit Score: 119.27 E-value: 2.53e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 320 PSKVRDLYAQFKGIE-----KLYEWQHT-CLTLNSvqeRKNLIYSLPTSGGKTLVAEI---LMLQE-------------- 376
Cdd:COG4581 5 PARADARLEALADFAeergfELDPFQEEaILALEA---GRSVLVAAPTGSGKTLVAEFaifLALARgrrsfytapikals 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 377 ------------------------------LLCCRKDVL--MIL-------PYVAIVQEKLHMIGEGSRGATLEmtlAKI 417
Cdd:COG4581 82 nqkffdlverfgaenvglltgdasvnpdapIVVMTTEILrnMLYregadleDVGVVVMDEFHYLADPDRGWVWE---EPI 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 418 LYTSKTTQIIGMSATLNNVEDLQKFLQA-----EYYTSQFRPVELKEYLKINDTIYEVDSKAENGMTFSRLlnykySDTL 492
Cdd:COG4581 159 IHLPARVQLVLLSATVGNAEEFAEWLTRvrgetAVVVSEERPVPLEFHYLVTPRLFPLFRVNPELLRPPSR-----HEVI 233
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 493 KKMDPDHLValvteviPNYsclVFCPSKKNCENVAEMIckfLSKEYLKHKEKEK-CEVIKNLKNIGNGNLCPVLKRTIPF 571
Cdd:COG4581 234 EELDRGGLL-------PAI---VFIFSRRGCDEAAQQL---LSARLTTKEERAEiREAIDEFAEDFSVLFGKTLSRLLRR 300
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 572 GVAYHHSGLTSDERKLLEEAYSTG---VLClftCTSTLAAGVNLPARRVIL----------RAPYVAKEFLkrnqykQMI 638
Cdd:COG4581 301 GIAVHHAGMLPKYRRLVEELFQAGllkVVF---ATDTLAVGINMPARTVVFtklskfdgerHRPLTAREFH------QIA 371
|
410 420 430
....*....|....*....|....*....|....*.
gi 1844084119 639 GRAGRAGIDTIGESILILQE-KDKQQVLELITKPLE 673
Cdd:COG4581 372 GRAGRRGIDTEGHVVVLAPEhDDPKKFARLASARPE 407
|
|
| DEXHc_Ski2 |
cd17921 |
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases ... |
336-447 |
8.23e-19 |
|
DEXH-box helicase domain of DEAD-like helicase Ski2 family proteins; Ski2-like RNA helicases play an important role in RNA degradation, processing, and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350679 [Multi-domain] Cd Length: 181 Bit Score: 85.01 E-value: 8.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 336 LYEWQHTCLTLnSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKL----------------- 398
Cdd:cd17921 2 LNPIQREALRA-LYLSGDSVLVSAPTSSGKTLIAELAILRALATSGGKAVYIAPTRALVNQKEadlrerfgplgknvgll 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 399 -----------------------------------------------HMIGEGSRGATLEMTLAKILYTSKTTQIIGMSA 431
Cdd:cd17921 81 tgdpsvnklllaeadilvatpekldlllrnggerliqdvrlvvvdeaHLIGDGERGVVLELLLSRLLRINKNARFVGLSA 160
|
170
....*....|....*.
gi 1844084119 432 TLNNVEDLQKFLQAEY 447
Cdd:cd17921 161 TLPNAEDLAEWLGVED 176
|
|
| COG1202 |
COG1202 |
Superfamily II helicase, archaea-specific [Replication, recombination and repair]; |
393-661 |
1.61e-15 |
|
Superfamily II helicase, archaea-specific [Replication, recombination and repair];
Pssm-ID: 440815 [Multi-domain] Cd Length: 790 Bit Score: 81.48 E-value: 1.61e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 393 IVQEKLHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTSQFRPVELKEYLkindtiyevds 472
Cdd:COG1202 330 VVIDEVHMLEDPERGHRLDGLIARLKYYCPGAQWIYLSATVGNPEELAKKLGAKLVEYEERPVPLERHL----------- 398
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 473 kaengmTFSRllNYKYSDTLKKmdpdhlvaLVTEVIPNYS-------CLVFCPSKKNCENVAemickflskeylkhkeke 545
Cdd:COG1202 399 ------TFAD--GREKIRIINK--------LVKREFDTKSskgyrgqTIIFTNSRRRCHEIA------------------ 444
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 546 kceviknlknigngnlcpvlkRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLPARRVILRAPYVA 625
Cdd:COG1202 445 ---------------------RALGYKAAPYHAGLDYGERKKVERRFADQELAAVVTTAALAAGVDFPASQVIFDSLAMG 503
|
250 260 270
....*....|....*....|....*....|....*.
gi 1844084119 626 KEFLKRNQYKQMIGRAGRAGIDTIGEsILILQEKDK 661
Cdd:COG1202 504 IEWLSVQEFHQMLGRAGRPDYHDRGK-VYLLVEPGK 538
|
|
| DEXHc_archSki2 |
cd18028 |
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play ... |
353-450 |
2.11e-13 |
|
DEXH-box helicase domain of archaeal Ski2-type helicase; Archaeal Ski2-type RNA helicases play an important role in RNA degradation, processing and splicing pathways. They belong to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350786 [Multi-domain] Cd Length: 177 Bit Score: 69.29 E-value: 2.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 353 KNLIYSLPTSGGKTLVAEILMLQELLCCRKdVLMILPYVAIVQEK----------------------------------- 397
Cdd:cd18028 18 ENLLISIPTASGKTLIAEMAMVNTLLEGGK-ALYLVPLRALASEKyeefkkleeiglkvgistgdydeddewlgdydiiv 96
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 398 ---------------------------LHMIGEGSRGATLEMTLAKILYTSKTTQIIGMSATLNNVEDLQKFLQAEYYTS 450
Cdd:cd18028 97 atyekfdsllrhspswlrdvgvvvvdeIHLISDEERGPTLESIVARLRRLNPNTQIIGLSATIGNPDELAEWLNAELVES 176
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
567-645 |
1.28e-12 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 64.16 E-value: 1.28e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 567 RTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKEflkrnQYKQMIGRAGRAG 645
Cdd:smart00490 8 KELGIKVARLHGGLSQEEREEILDKFNNGKIKVLVATDVAERGLDLPgVDLVIIYDLPWSPA-----SYIQRIGRAGRAG 82
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
536-645 |
3.66e-10 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 57.99 E-value: 3.66e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 536 KEYLKHKEKEKCEVIKNLKNIGNGNLcpvLKRTIPFGVAYHHSGLTSDERKLLEEAYSTGVLCLFTCTSTLAAGVNLP-A 614
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLEAEL---LLEKEGIKVARLHGDLSQEEREEILEDFRKGKIDVLVATDVAERGLDLPdV 83
|
90 100 110
....*....|....*....|....*....|..
gi 1844084119 615 RRVI-LRAPYvakeflKRNQYKQMIGRAGRAG 645
Cdd:pfam00271 84 DLVInYDLPW------NPASYIQRIGRAGRAG 109
|
|
| SF2_C_LHR |
cd18796 |
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a ... |
512-643 |
7.07e-06 |
|
C-terminal helicase domain of LHR family helicases; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases. LHR family helicases are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350183 [Multi-domain] Cd Length: 150 Bit Score: 46.87 E-value: 7.07e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 512 SCLVFCPSKKNCENVAEmickflskeylkhkekekcevikNLKNigngnLCPvlKRTIPFGVAYHHSGLTSDERKLLEEA 591
Cdd:cd18796 40 STLVFTNTRSQAERLAQ-----------------------RLRE-----LCP--DRVPPDFIALHHGSLSRELREEVEAA 89
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....
gi 1844084119 592 YSTGVLCLFTCTSTLAAGVNLPA-RRVI-LRAPYVAKEFLKRnqykqmIGRAGR 643
Cdd:cd18796 90 LKRGDLKVVVATSSLELGIDIGDvDLVIqIGSPKSVARLLQR------LGRSGH 137
|
|
| YprA |
COG1205 |
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, ... |
500-658 |
2.37e-05 |
|
ATP-dependent helicase YprA, contains C-terminal metal-binding DUF1998 domain [Replication, recombination and repair];
Pssm-ID: 440818 [Multi-domain] Cd Length: 758 Bit Score: 48.29 E-value: 2.37e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 500 LVALVTEvipNYSCLVFCPSKKNCENVAEMICKFLSKEYLKHKekekceviknlknigngnlcpvlkrtipfgVAYHHSG 579
Cdd:COG1205 281 LADLVRE---GLRTLVFTRSRRGAELLARYARRALREPDLADR------------------------------VAAYRAG 327
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 580 LTSDERKLLEEAYSTG-VLCLFTcTSTLAAGVNLP---ArrVILRA-PYvakeflKRNQYKQMIGRAGRAGIDtiGESIL 654
Cdd:COG1205 328 YLPEERREIERGLRSGeLLGVVS-TNALELGIDIGgldA--VVLAGyPG------TRASFWQQAGRAGRRGQD--SLVVL 396
|
....
gi 1844084119 655 ILQE 658
Cdd:COG1205 397 VAGD 400
|
|
| DEXHc_HFM1 |
cd18023 |
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box ... |
399-454 |
1.60e-04 |
|
DEXH-box helicase domain of ATP-dependent DNA helicase HFM1; HFM1 is a type II DEAD box helicase, required for crossover formation and complete synapsis of homologous chromosomes during meiosis. HFM1 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350781 [Multi-domain] Cd Length: 206 Bit Score: 43.88 E-value: 1.60e-04
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1844084119 399 HMIGEgSRGATLEMTLA--KILYTSKTT--------QIIGMSATLNNVEDLQKFLQAEY-----YTSQFRP 454
Cdd:cd18023 137 HIIKE-NRGATLEVVVSrmKTLSSSSELrgstvrpmRFVAVSATIPNIEDLAEWLGDNPagcfsFGESFRP 206
|
|
| DEXHc_Brr2_1 |
cd18019 |
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD ... |
333-443 |
5.72e-04 |
|
N-terminal DEXH-box helicase domain of spliceosomal Brr2 RNA helicase; Brr2 is a type II DEAD box helicase that mediates spliceosome catalytic activation. It is a stable subunit of the spliceosome, required during splicing catalysis and spliceosome disassembly. Brr2 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350777 [Multi-domain] Cd Length: 214 Bit Score: 42.36 E-value: 5.72e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 333 IEKLYEWQHTCL----TLNSVQER---------KNLIYSLPTSGGKTLVAEILMLQELLCCRKD----------VLMILP 389
Cdd:cd18019 1 IEELPDWAQPAFegfkSLNRIQSKlfpaafetdENLLLCAPTGAGKTNVALLTILREIGKHRNPdgtinldafkIVYIAP 80
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90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 1844084119 390 YVAIVQE-----------------------------------------------------------KLHMIGE-----GS 405
Cdd:cd18019 81 MKALVQEmvgnfskrlapygitvaeltgdqqltkeqisetqiivttpekwdiitrksgdrtytqlvRLIIIDEihllhDD 160
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170 180 190 200
....*....|....*....|....*....|....*....|..
gi 1844084119 406 RGATLEMTLAKILYTSKTTQ----IIGMSATLNNVEDLQKFL 443
Cdd:cd18019 161 RGPVLESIVARTIRQIEQTQeyvrLVGLSATLPNYEDVATFL 202
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| DEXHc_LHR-like |
cd17922 |
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA ... |
388-443 |
5.99e-04 |
|
DEXH-box helicase domain of LHR; Large helicase-related protein (LHR) is a DNA damage-inducible helicase that uses ATP hydrolysis to drive unidirectional 3'-to-5' translocation along single-stranded DNA (ssDNA) and to unwind RNA:DNA duplexes. This group also includes related bacterial and archaeal helicases from the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350680 [Multi-domain] Cd Length: 166 Bit Score: 41.80 E-value: 5.99e-04
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*..
gi 1844084119 388 LPYVaIVQEkLHMIGEGSRGATLEMTLAKI-LYTSKTTQIIGMSATLNNVEDLQKFL 443
Cdd:cd17922 112 LRYV-VVDE-IHALLGSKRGVQLELLLERLrKLTGRPLRRIGLSATLGNLEEAAAFL 166
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| SF2-N |
cd00046 |
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily ... |
353-412 |
2.17e-03 |
|
N-terminal DEAD/H-box helicase domain of superfamily 2 helicases; The DEAD/H-like superfamily 2 helicases comprise a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This N-terminal domain contains the ATP-binding region.
Pssm-ID: 350668 [Multi-domain] Cd Length: 146 Bit Score: 39.69 E-value: 2.17e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 1844084119 353 KNLIYSLPTSGGKTLVAEILMLQELLCCRKDVLMILPYVAIVQEKLHMIGE-GSRGATLEM 412
Cdd:cd00046 2 ENVLITAPTGSGKTLAALLAALLLLLKKGKKVLVLVPTKALALQTAERLRElFGPGIRVAV 62
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| HHH_5 |
pfam14520 |
Helix-hairpin-helix domain; |
946-999 |
2.72e-03 |
|
Helix-hairpin-helix domain;
Pssm-ID: 434010 [Multi-domain] Cd Length: 57 Bit Score: 37.08 E-value: 2.72e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....
gi 1844084119 946 LMEVTGVLEGRAKQLYSAGYKSLMHLANANPEVLVRTIDhLSRRQAKQIVSSAK 999
Cdd:pfam14520 4 LLSISGIGPKTALALLSAGIGTVEDLAEADVDELAEIPG-IGEKTAQRIILELR 56
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| SF2_C |
cd18785 |
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases ... |
585-655 |
7.69e-03 |
|
C-terminal helicase domain of superfamily 2 DEAD/H-box helicases; Superfamily (SF)2 helicases include DEAD-box helicases, UvrB, RecG, Ski2, Sucrose Non-Fermenting (SNF) family helicases, and dicer proteins, among others. Similar to SF1 helicases, they do not form toroidal structures like SF3-6 helicases. SF2 helicases are a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Their helicase core is surrounded by C- and N-terminal domains with specific functions such as nucleases, RNA or DNA binding domains, or domains engaged in protein-protein interactions. The core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350172 [Multi-domain] Cd Length: 77 Bit Score: 36.14 E-value: 7.69e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 1844084119 585 RKLLEEAYStgVLCLFTCTSTLAAGVNLP-ARRVILRAPYVAKeflkrNQYKQMIGRAGRAGiDTIGESILI 655
Cdd:cd18785 13 IEHAEEIAS--SLEILVATNVLGEGIDVPsLDTVIFFDPPSSA-----ASYIQRVGRAGRGG-KDEGEVILF 76
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| DEXHc_ASCC3_1 |
cd18020 |
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; ... |
393-452 |
7.77e-03 |
|
N-terminal DEXH-box helicase domain of Activating signal cointegrator 1 complex subunit 3; Activating signal cointegrator 1 complex subunit 3 (ASCC3) is a type II DEAD box helicase that plays a role in the repair of N-alkylated nucleotides. ASCC3 belongs to the type II DEAD box helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350778 [Multi-domain] Cd Length: 199 Bit Score: 38.95 E-value: 7.77e-03
10 20 30 40 50 60
....*....|....*....|....*....|....*....|....*....|....*....|....
gi 1844084119 393 IVQEKLHMIGEgSRGATLEMTLAKILYTSKTTQ----IIGMSATLNNVEDLQKFLQAEYYTSQF 452
Cdd:cd18020 134 LIIDEVHLLHD-DRGPVIESLVARTLRQVESTQsmirIVGLSATLPNYLDVADFLRVNPYKGLF 196
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|
| DEAD |
pfam00270 |
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. ... |
345-398 |
7.88e-03 |
|
DEAD/DEAH box helicase; Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.
Pssm-ID: 425570 [Multi-domain] Cd Length: 165 Bit Score: 38.38 E-value: 7.88e-03
10 20 30 40 50
....*....|....*....|....*....|....*....|....*....|....*.
gi 1844084119 345 TLNSVQERKNLIYSLPTSGGKTLVAEILMLQELLCCRKD--VLMILPYVAIVQEKL 398
Cdd:pfam00270 7 AIPAILEGRDVLVQAPTGSGKTLAFLLPALEALDKLDNGpqALVLAPTRELAEQIY 62
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