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Conserved domains on  [gi|662236768|ref|NP_001284518|]
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zinc finger protein 221 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12016853)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 30-70 1.26e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


:

Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.26e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 662236768   30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVG 70
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-576 1.36e-07

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 166 QQKPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCG--ECGKSFCYSPALHIHQRVHMgekcykcdvcgkefNQSSHLQT 243
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH--------------NNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 244 HQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYN-------CEECGKAFIHDSQLQEHQRIHTGEKPFKCDI-- 314
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAns 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 315 CGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPY 394
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 395 NCKECGKTFR--WSSCLLNHQQVHSGQ-----KSFKCEECGKGFYTNSRRSSHQRS--HNGE--KPYNCEE--CGKDYKR 461
Cdd:COG5048  256 SASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 462 RLDLEFHQRVHTGERPYNCK--ECGKSFGWAS-----------CLLKHQRLHSGEKPFKCEECGKRFTqsSQLHSHQTCH 528
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppqslqqyKDLKNDKKSETLSNSCIRNFKRDSN--LSLHIITHLS 413

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 662236768 529 TGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCKECGKSFGWASC 576
Cdd:COG5048  414 FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 30-70 1.26e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.26e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 662236768   30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVG 70
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
30-72 2.59e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.59e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 662236768    30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGNQ 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 30-68 1.28e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 1.28e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 662236768  30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLS 68
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-576 1.36e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 166 QQKPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCG--ECGKSFCYSPALHIHQRVHMgekcykcdvcgkefNQSSHLQT 243
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH--------------NNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 244 HQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYN-------CEECGKAFIHDSQLQEHQRIHTGEKPFKCDI-- 314
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAns 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 315 CGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPY 394
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 395 NCKECGKTFR--WSSCLLNHQQVHSGQ-----KSFKCEECGKGFYTNSRRSSHQRS--HNGE--KPYNCEE--CGKDYKR 461
Cdd:COG5048  256 SASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 462 RLDLEFHQRVHTGERPYNCK--ECGKSFGWAS-----------CLLKHQRLHSGEKPFKCEECGKRFTqsSQLHSHQTCH 528
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppqslqqyKDLKNDKKSETLSNSCIRNFKRDSN--LSLHIITHLS 413

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 662236768 529 TGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCKECGKSFGWASC 576
Cdd:COG5048  414 FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 224-273 4.14e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 4.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 662236768 224 KCYKCDvcgKEFNQSSHLQTHQRvhtgEKPFKCGQCGKGFHSRSALNVHC 273
Cdd:cd20908    3 WCYYCD---REFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-319 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|...
gi 662236768  297 LQEHQRIHTGEKPFKCDICGKSF 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
 
Name Accession Description Interval E-value
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 30-70 1.26e-22

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 90.61  E-value: 1.26e-22
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|.
gi 662236768   30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVG 70
Cdd:pfam01352   2 VTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB smart00349
krueppel associated box;
30-72 2.59e-22

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 90.34  E-value: 2.59e-22
                           10        20        30        40
                   ....*....|....*....|....*....|....*....|...
gi 662236768    30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLSVGNQ 72
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQ 43
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 30-68 1.28e-17

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 76.43  E-value: 1.28e-17
                         10        20        30
                 ....*....|....*....|....*....|....*....
gi 662236768  30 VTFKDVAVVFTEEELGLLDPAQRKLYRDVMLENFRNLLS 68
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVS 39
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
166-576 1.36e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 54.32  E-value: 1.36e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 166 QQKPYRCNECKQSFSDVSVFDLHQQSHSGEKSHTCG--ECGKSFCYSPALHIHQRVHMgekcykcdvcgkefNQSSHLQT 243
Cdd:COG5048   30 APRPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSysGCDKSFSRPLELSRHLRTHH--------------NNPSDLNS 95

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 244 HQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYN-------CEECGKAFIHDSQLQEHQRIHTGEKPFKCDI-- 314
Cdd:COG5048   96 KSLPLSNSKASSSSLSSSSSNSNDNNLLSSHSLPPSSRDPqlpdllsISNLRNNPLPGNNSSSVNTPQSNSLHPPLPAns 175

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 315 CGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVHIEEKPYKCEQCGKGFICRRDFCKHQMVHTGEKPY 394
Cdd:COG5048  176 LSKDPSSNLSLLISSNVSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSS 255

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 395 NCKECGKTFR--WSSCLLNHQQVHSGQ-----KSFKCEECGKGFYTNSRRSSHQRS--HNGE--KPYNCEE--CGKDYKR 461
Cdd:COG5048  256 SASESPRSSLptASSQSSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCPYslCGKLFSR 335

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 462 RLDLEFHQRVHTGERPYNCK--ECGKSFGWAS-----------CLLKHQRLHSGEKPFKCEECGKRFTqsSQLHSHQTCH 528
Cdd:COG5048  336 NDALKRHILLHTSISPAKEKllNSSSKFSPLLnneppqslqqyKDLKNDKKSETLSNSCIRNFKRDSN--LSLHIITHLS 413

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*...
gi 662236768 529 TGEKLYKCEQCEKGYNSKFNLDMHQRVHGGERPYNCKECGKSFGWASC 576
Cdd:COG5048  414 FRPYNCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKSFRRDLDL 461
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
224-590 5.80e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 52.39  E-value: 5.80e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 224 KCYKCDVCGKEFNQSSHLQTHQRVHTGEKPFKCGQ--CGKGFHSRSALNVHCKLHTGEKPYNCE-ECGKAFIHDSQLQEH 300
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHNNPSDLNSkSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 301 QRIHTGEKPFKCDICGKSFRVRSRL------------NRHSMVHTGEKPFRCDT-----------CGKNFRQRSALNSHS 357
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRDPQlpdllsisnlrnNPLPGNNSSSVNTPQSNslhpplpanslSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 358 MVHIEEKPYKCEQCGKgFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNHQQVHSGQKSFKCEECGKGFYTNSRR 437
Cdd:COG5048  192 VSTSIPSSSENSPLSS-SYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLPTASS 270

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 438 SSHQRSHNGE-------KPYNCEECGKDYKRRLDLEFHQR--VHTGE--RPYNCKE--CGKSFGWASCLLKHQRLHSGEK 504
Cdd:COG5048  271 QSSSPNESDSssekgfsLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSIS 350

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 505 PFKC--EECGKRFTQSS-----QLHSHQTCHTGEKLYKCE--QCEKGYNSKFNLDMHQRVHGGERPYNCK--ECGKSFGW 573
Cdd:COG5048  351 PAKEklLNSSSKFSPLLnneppQSLQQYKDLKNDKKSETLsnSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNR 430

                        410
                 ....*....|....*..
gi 662236768 574 ASCLLKHQRLHSGEKPL 590
Cdd:COG5048  431 HYNLIPHKKIHTNHAPL 447
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-608 9.11e-07

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 51.62  E-value: 9.11e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 280 KPYNCEECGKAFIHDSQLQEHQRIHTGEKPFKC--DICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHS 357
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCsySGCDKSFSRPLELSRHLRTHHNNPSDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 358 MVH-IEEKPYKCEQCGKG------------FICRRDFCKHQMVHTGEK----------PYNCKECGKTFRWSSCLLNHQQ 414
Cdd:COG5048  112 SSSsNSNDNNLLSSHSLPpssrdpqlpdllSISNLRNNPLPGNNSSSVntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 415 VHSGQKSFKCEECGKGFYTNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEFHQRVHTGERPYNCKECGKSFG--WASC 492
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPSSLSSSDSSSSASESPRSSLptASSQ 271

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 493 LLKHQRLHSGE-----KPFKCEECGKRFTQSSQLHSHQTC--HTGEKLYKCEQCEKGYNSKF----NLDMHQRVHGGERP 561
Cdd:COG5048  272 SSSPNESDSSSekgfsLPIKSKQCNISFSRSSPLTRHLRSvnHSGESLKPFSCPYSLCGKLFsrndALKRHILLHTSISP 351

                        330       340       350       360
                 ....*....|....*....|....*....|....*....|....*....
gi 662236768 562 YNCK--ECGKSFGWASCLLKHQRLHSGEKPLKSGVWEEIYSEFTASFTS 608
Cdd:COG5048  352 AKEKllNSSSKFSPLLNNEPPQSLQQYKDLKNDKKSETLSNSCIRNFKR 400
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 224-273 4.14e-05

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 42.16  E-value: 4.14e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|
gi 662236768 224 KCYKCDvcgKEFNQSSHLQTHQRvhtgEKPFKCGQCGKGFHSRSALNVHC 273
Cdd:cd20908    3 WCYYCD---REFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHC 45
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
163-357 6.40e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.84  E-value: 6.40e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 163 SHVQQKPYRCNECKQSFSDVSVFDLHQQSHSG-EKSHTCGECGKSFCYSPALHIHQR--VHMGEKC--YKCDV--CGKEF 235
Cdd:COG5048  254 SSSASESPRSSLPTASSQSSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGESLkpFSCPYslCGKLF 333

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 236 NQSSHLQTHQRVHTGEKPFKC--GQCGKGFH------SRSALNVHCKLHTGEKPYNCE-ECGKAFIHDSQLQEHQRIHTG 306
Cdd:COG5048  334 SRNDALKRHILLHTSISPAKEklLNSSSKFSpllnnePPQSLQQYKDLKNDKKSETLSnSCIRNFKRDSNLSLHIITHLS 413

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|...
gi 662236768 307 EKP--FKCDICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKnFRQRSALNSHS 357
Cdd:COG5048  414 FRPynCKNPPCSKSFNRHYNLIPHKKIHTNHAPLLCSILKS-FRRDLDLSNHG 465
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
280-441 9.05e-05

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 45.46  E-value: 9.05e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 280 KPYNCEECGKAFIHDSQLQEHQR--IHTGE--KPFKCDI--CGKSFRVRSRLNRHSMVHTGEKPFRC--DTCGKNFRQRS 351
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEklLNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 352 ALNSHSMVHIEEKP-YKCEQCGKGFICRRDF------CKHQMVHTGEKPYNCK--ECGKTFRWSSCLLNHQQVHSGQKSF 422
Cdd:COG5048  368 NNEPPQSLQQYKDLkNDKKSETLSNSCIRNFkrdsnlSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAPL 447

                        170
                 ....*....|....*....
gi 662236768 423 KCEECGKGFYTNSRRSSHQ 441
Cdd:COG5048  448 LCSILKSFRRDLDLSNHGK 466
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 434-526 1.88e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 44.32  E-value: 1.88e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 434 NSRRSSHQRSHNGEKPYNCE--ECGKDYKRRLDLEFHqRVHtgerpyncKECGKSFGWASCLLKHQRLHSGEKPFKCEEC 511
Cdd:COG5189  334 NIDTPSRMLKVKDGKPYKCPveGCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVC 404

                         90
                 ....*....|....*
gi 662236768 512 GKRFTQSSQLHSHQT 526
Cdd:COG5189  405 DKRYKNLNGLKYHRK 419
zf-H2C2_2 pfam13465
Zinc-finger double domain;
297-319 2.81e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 2.81e-04
                          10        20
                  ....*....|....*....|...
gi 662236768  297 LQEHQRIHTGEKPFKCDICGKSF 319
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSF 24
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 279-373 2.96e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.55  E-value: 2.96e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 279 EKPYNCEECGKAFIHDSQLQ---EHQRIHT-GEKPFKCDI--CGKSFRVRSRLNRHsMVHTGEKPFRCDTcgknfrqrSA 352
Cdd:COG5189  315 KLPCTNSSSNGKLAHGGERNidtPSRMLKVkDGKPYKCPVegCNKKYKNQNGLKYH-MLHGHQNQKLHEN--------PS 385

                         90       100
                 ....*....|....*....|.
gi 662236768 353 LNSHSMVHIEEKPYKCEQCGK 373
Cdd:COG5189  386 PEKMNIFSAKDKPYRCEVCDK 406
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 221-300 6.93e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 6.93e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 221 MGEKCYKCDV--CGKEFNQSSHLQTHqRVHtgekpfkcGQCGKGFHSRSALNVHCKLHTGEKPYNCEECGKAFIHDSQLQ 298
Cdd:COG5189  345 KDGKPYKCPVegCNKKYKNQNGLKYH-MLH--------GHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ..
gi 662236768 299 EH 300
Cdd:COG5189  416 YH 417
zf-H2C2_2 pfam13465
Zinc-finger double domain;
493-517 1.71e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.20  E-value: 1.71e-03
                          10        20
                  ....*....|....*....|....*
gi 662236768  493 LLKHQRLHSGEKPFKCEECGKRFTQ 517
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 390-473 2.09e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 2.09e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 662236768 390 GEKPYNCK--ECGKTFRWSSCLLNHQQvhSGQKSFKCEEcgkgfytNSRRSSHQRSHNGEKPYNCEECGKDYKRRLDLEF 467
Cdd:COG5189  346 DGKPYKCPveGCNKKYKNQNGLKYHML--HGHQNQKLHE-------NPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*.
gi 662236768 468 HqRVHT 473
Cdd:COG5189  417 H-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
240-263 2.69e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.42  E-value: 2.69e-03
                          10        20
                  ....*....|....*....|....
gi 662236768  240 HLQTHQRVHTGEKPFKCGQCGKGF 263
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-H2C2_2 pfam13465
Zinc-finger double domain;
268-293 3.50e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 3.50e-03
                          10        20
                  ....*....|....*....|....*.
gi 662236768  268 ALNVHCKLHTGEKPYNCEECGKAFIH 293
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
464-487 4.31e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 35.04  E-value: 4.31e-03
                          10        20
                  ....*....|....*....|....
gi 662236768  464 DLEFHQRVHTGERPYNCKECGKSF 487
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSF 24
zf-C2H2 pfam00096
Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two ...
 226-248 5.11e-03

Zinc finger, C2H2 type; The C2H2 zinc finger is the classical zinc finger domain. The two conserved cysteines and histidines co-ordinate a zinc ion. The following pattern describes the zinc finger. #-X-C-X(1-5)-C-X3-#-X5-#-X2-H-X(3-6)-[H/C] Where X can be any amino acid, and numbers in brackets indicate the number of residues. The positions marked # are those that are important for the stable fold of the zinc finger. The final position can be either his or cys. The C2H2 zinc finger is composed of two short beta strands followed by an alpha helix. The amino terminal part of the helix binds the major groove in DNA binding zinc fingers. The accepted consensus binding sequence for Sp1 is usually defined by the asymmetric hexanucleotide core GGGCGG but this sequence does not include, among others, the GAG (=CTC) repeat that constitutes a high-affinity site for Sp1 binding to the wt1 promoter.


Pssm-ID: 395048 [Multi-domain]  Cd Length: 23  Bit Score: 34.58  E-value: 5.11e-03
                          10        20
                  ....*....|....*....|...
gi 662236768  226 YKCDVCGKEFNQSSHLQTHQRVH 248
Cdd:pfam00096   1 YKCPDCGKSFSRKSNLKRHLRTH 23
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 280-332 7.45e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 36.00  E-value: 7.45e-03
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....
gi 662236768 280 KPYnCEECGKAFIHDSQLQEHQRIHTgekpFKCDICGKSFRVRSRLNRHSM-VH 332
Cdd:cd20908    1 KPW-CYYCDREFDDEKILIQHQKAKH----FKCHICHKKLYTAGGLAVHCLqVH 49
SUF4-like cd20908
N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), ...
 203-248 8.71e-03

N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins; Oryza sativa SUPPRESSOR OF FRI 4 (OsSUF4) is a C2H2-type zinc finger transcription factor which interacts with the major H3K36 methyltransferase SDG725 to promote H3K36me3 (tri-methylation at H3K9) establishment. The transcription factor OsSUF4 recognizes a specific 7-bp DNA element (5'-CGGAAAT-3'), which is contained in the promoter regions of many genes throughout the rice genome. Through interaction with OsSUF4, SDG725 is recruited to the promoters of key florigen genes, RICE FLOWERING LOCUS T1 (RFT1) and Heading date 3a (Hd3a), for H3K36 deposition to promote gene activation and rice plant flowering. OsSUF4 target genes include a number of genes involved in many biological processes. Flowering plant Arabidopsis SUF4 binds to a 15bp DNA element (5'-CCAAATTTTAAGTTT-3') within the promoter of the floral repressor gene FLOWERING LOCUS C (FLC) and recruits the FRI-C transcription activator complex to the FLC promoter. Although the DNA-binding element and target genes of AtSUF4 are different from those of OsSUF4, AtSUF4 is known to interact with the Arabidopsis H3K36 methyltransferase SDG8 (also known as ASHH2/EFS/SET8), and the methylation deposition mechanism mediated by the SUF4 transcription factor and H3K36 methyltransferase may be conserved in Arabidopsis and rice. Proteins in this family have two conserved C2H2-type zinc finger motifs at the N-terminus (included in this model), and a large proline-rich domain at the C-terminus; for OsSUF4, it has been shown that the N-terminal zinc-finger domain is responsible for DNA binding, and that the C-terminal domain interacts with SDG725.


Pssm-ID: 411020 [Multi-domain]  Cd Length: 82  Bit Score: 35.61  E-value: 8.71e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*..
gi 662236768 203 CGKSFCYSPALHIHQRvhmgEKCYKCDVCGKEFNQSSHLQTH-QRVH 248
Cdd:cd20908    7 CDREFDDEKILIQHQK----AKHFKCHICHKKLYTAGGLAVHcLQVH 49
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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