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Conserved domains on  [gi|729719230|ref|NP_001284346|]
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membrane-associated transporter protein isoform c [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 35-187 1.35e-63

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17313:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 421  Bit Score: 204.01  E-value: 1.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729719230 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFT 187
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMG 150
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 35-187 1.35e-63

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 204.01  E-value: 1.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729719230 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFT 187
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMG 150
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 31-186 4.83e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 82.54  E-value: 4.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230   31 PTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLG 110
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  111 VmmLVGMALYLNG-ATVVAALIANPRRKLV--WAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEK--GLHYHAL 185
Cdd:TIGR01301  82 A--LVAFAVILIGfAADIGHLFGDNLDKKTkpRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSF 159


                  .
gi 729719230  186 F 186
Cdd:TIGR01301 160 F 160
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-165 1.10e-15

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 75.71  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  28 PKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYI 106
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 729719230 107 LTLGVMMLVGMALylngatVVAALIANPRRKLVWAIsvtmIGVVLFDFAADFIDGPIKA 165
Cdd:COG2211   85 LIGAIPLALSFVL------LFTAPDLSPTGKLIYAL----VTYLLLGLAYTLVNIPYSA 133
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 37-154 2.23e-07

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 50.77  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230   37 MHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLV 115
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 729719230  116 GMALylngatVVAALIANPRRKLVWAIsVTMIGV-VLFDF 154
Cdd:pfam13347  81 SFIL------LFTPPELGRAPLFIWLL-ATYILLrIAYTF 113
PRK11462 PRK11462
putative transporter; Provisional
 64-130 1.27e-03

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 39.53  E-value: 1.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729719230  64 GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYIL----TLGVMMLVGMA---LYLNGATVVAAL 130
Cdd:PRK11462  41 GIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLfgalPFGIVCVLAYStpdLSMNGKMIYAAI 114
 
Name Accession Description Interval E-value
MFS_SLC45_SUC cd17313
Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily ...
 35-187 1.35e-63

Solute carrier family 45 and similar sugar transporters of the Major Facilitator Superfamily of transporters; This group includes the solute carrier 45 (SLC45) family as well as plant sucrose transporters (SUCs or SUTs) and similar proteins such as Schizosaccharomyces pombe general alpha-glucoside permease. the SLC45 family is composed of four (A1-A4) vertebrate proteins as well as related insect proteins such as Drosophila sucrose transporter SCRT or Slc45-1. Members of this group transport sucrose and other sugars like maltose into the cell, with the concomitant uptake of protons (symport system). Plant sucrose transporters are crucial to carbon partitioning, playing a key role in phloem loading/unloading. They play a key role in loading and unloading of sucrose into the phloem and as a result, they control sucrose distribution throughout the whole plant and drive the osmotic flow system in the phloem. They also play a role in the exchange of sucrose between beneficial symbionts (mycorrhiza and Rhizobium) as well as pathogens such as nematodes and parasitic fungi. There are nine sucrose transporter genes in Arabidopsis and five in rice. Vertebrate SLC45 family proteins have been implicated in the regulation of glucose homoeostasis in the brain (SLC45A1), with skin and hair pigmentation (SLC45A2), and with prostate cancer and myelination (SLC45A3). Mutations in SLC45A2, also called MATP (membrane-associated transporter protein) or melanoma antigen AIM1, cause oculocutaneous albinism type 4 (OCA4), an autosomal recessive disorder of melanin biosynthesis that results in congenital hypopigmentation of ocular and cutaneous tissues. The SLC45 family and related sugar transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340871 [Multi-domain]  Cd Length: 421  Bit Score: 204.01  E-value: 1.35e-63
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMML 114
Cdd:cd17313    1 LFLLGFGFFGIEFGWALENSYVPPILQTLGLSHALIGFVWTLGPILGLFVQPLVGSLSDRCNSRIGRRRPFILVGAPLAA 80

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 729719230 115 VGMALYLNGATVVAALIANPRRklvWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFT 187
Cdd:cd17313   81 LGLILIPNAADIGLALGDGPRT---WALVLFVLGIVLLDFAMNVCQGPVRALLPDLVPPEQRSKANGIINFMG 150
GPH_sucrose TIGR01301
GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in ...
 31-186 4.83e-18

GPH family sucrose/H+ symporter; This model represents sucrose/proton symporters, found in plants, from the Glycoside-Pentoside-Hexuronide (GPH)/cation symporter family. These proteins are predicted to have 12 transmembrane domains. Members may export sucrose (e.g. SUT1, SUT4) from green parts to the phloem for long-distance transport or import sucrose (e.g SUT2) to sucrose sinks such as the tap root of the carrot.


Pssm-ID: 273545 [Multi-domain]  Cd Length: 477  Bit Score: 82.54  E-value: 4.83e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230   31 PTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLG 110
Cdd:TIGR01301   2 PLRKLLRVASVAAGVQFGWALQLSLLTPYVQELGIPHAWASIIWLCGPLSGLLVQPLVGYLSDRCTSRFGRRRPFIAAGA 81

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  111 VmmLVGMALYLNG-ATVVAALIANPRRKLV--WAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEK--GLHYHAL 185
Cdd:TIGR01301  82 A--LVAFAVILIGfAADIGHLFGDNLDKKTkpRAIIVFVVGFWILDVANNMLQGPCRAFLADLTGGDARRTriANAYFSF 159


                  .
gi 729719230  186 F 186
Cdd:TIGR01301 160 F 160
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
28-165 1.10e-15

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 75.71  E-value: 1.10e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  28 PKRPTSRLIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYI 106
Cdd:COG2211    5 KKLSLKEKLAYGLGDLGLNLAFGLLSAYLLYFYTDVlGLSAALVGLILLVARLWDAITDPLIGALSDRTRTRWGRRRPWI 84

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 729719230 107 LTLGVMMLVGMALylngatVVAALIANPRRKLVWAIsvtmIGVVLFDFAADFIDGPIKA 165
Cdd:COG2211   85 LIGAIPLALSFVL------LFTAPDLSPTGKLIYAL----VTYLLLGLAYTLVNIPYSA 133
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 39-187 1.63e-08

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 54.35  E-value: 1.63e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  39 SMAMFGREFCYAVEAAYVTPVLLSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMMLVGMA 118
Cdd:cd06174    2 LLGFFLTGLARGLISPLLPALLQSFGLSASQLGLLFALFSLGYALLQPLAGLLAD----RFGRRPVLLLGLLLFALGALL 77

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 729719230 119 LYlngatvvaalianprrkLVWAISVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGLHYHALFT 187
Cdd:cd06174   78 FA-----------------FAPSFWLLLLGRFLLGLGSGLIDPAVLALIADLFPERERGRALGLLQAFG 129
MFS_2 pfam13347
MFS/sugar transport protein; This family is part of the major facilitator superfamily of ...
 37-154 2.23e-07

MFS/sugar transport protein; This family is part of the major facilitator superfamily of membrane transport proteins.


Pssm-ID: 433134 [Multi-domain]  Cd Length: 427  Bit Score: 50.77  E-value: 2.23e-07
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230   37 MHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGVMMLV 115
Cdd:pfam13347   1 GYGSGALAAGIKYAGLATYLLYFYTDVlGLSAAAVGLVLLVARLVDAFTDPIVGHIIDRTRTRWGRRRPWLLLSAIILAV 80

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|
gi 729719230  116 GMALylngatVVAALIANPRRKLVWAIsVTMIGV-VLFDF 154
Cdd:pfam13347  81 SFIL------LFTPPELGRAPLFIWLL-ATYILLrIAYTF 113
MFS_MelB_like cd17332
Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major ...
 55-165 5.98e-07

Salmonella enterica Na+/melibiose symporter MelB and similar transporters of the Major Facilitator Superfamily; This family is composed of Salmonella enterica Na+/melibiose symporter MelB, Major Facilitator Superfamily domain-containing proteins, MFSD2 and MFSD12, and other sugar transporters. MelB catalyzes the electrogenic symport of galactosides with Na+, Li+ or H+. The MFSD2 subfamily is composed of two vertebrate members, MFSD2A and MFSD2B. MFSD2A is more commonly called sodium-dependent lysophosphatidylcholine symporter 1 (NLS1). It is an LPC symporter that plays an essential role for blood-brain barrier formation and function. Inactivating mutations in MFSD2A cause a lethal microcephaly syndrome. MFSD2B is a potential risk or protect factor in the prognosis of lung adenocarcinoma. MelB-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340890 [Multi-domain]  Cd Length: 424  Bit Score: 49.53  E-value: 5.98e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  55 YVTPVLlsvGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYILTLGV-MMLVGMALYLNGAtvvaaliAN 133
Cdd:cd17332   25 FYTDVL---GLSAAAAGTIFLVARIIDAINDPLMGYLIDRTRSRWGRFRPWLLWGAIpLALLFVLLFTTPD-------GS 94

                         90       100       110
                 ....*....|....*....|....*....|..
gi 729719230 134 PRRKLVWAISVTMigvvLFDFAADFIDGPIKA 165
Cdd:cd17332   95 GTGKLIYALITYI----LLDLLYTLVNIPYTA 122
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
35-160 6.90e-05

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 43.35  E-value: 6.90e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  35 LIMHSMAMFGREFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMM 113
Cdd:COG2211  230 FLLLLLAYLLFFLALALVAALLLYYFKYVlGLSAALVGLLLALYFLAALLGAPLWPRLAK----RFGKKKAFIIGLLLAA 305

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|....*...
gi 729719230 114 LVGMALYLNGAT-VVAALIANprrkLVWAISVTMIGVVLFDFAADFID 160
Cdd:COG2211  306 LGLLLLFFLGPGnLWLLLVLA----ALAGIGLGAILVLPWAMLADVVD 349
MFS_BCD_PucC-like cd06176
Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator ...
 61-157 2.02e-04

Bacteriochlorophyll delivery (BCD) family, also called PucC family, of the Major Facilitator Superfamily; The bacteriochlorophyll delivery (BCD) family, also called PucC family, is composed of the PucC protein and related proteins including LhaA (also called ORF477 and F1696) and bacteriochlorophyll synthase 44.5 kDa chain (also called ORF428). These proteins are found in photosynthetic organisms. Rhodobacter capsulatus LhaA and PucC are implicated in light-harvesting complex 1 and 2 (LH1 and LH2) assembly. PucC may function to shepherd or sequester LH2 alpha and beta proteins to facilitate proper assembly, as well as deliver bacteriochlorophyll a to nascent LH2 complexes. The BCD family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 349950 [Multi-domain]  Cd Length: 409  Bit Score: 41.72  E-value: 2.02e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  61 LSVGLPSSLYSIVWFLSPilgflLQPVVGSASDHCRSRWGRRRPYILtLGVMMLVGMALylnGATVVAALIANPRRK--- 137
Cdd:cd06176   33 LPATLVGLLIALHYLVAP-----LRVWIGHRSDTHPLRGYRRTPYIW-LGMLLLALGLA---LAPFAALLLAGAAFWlgl 103

                         90       100
                 ....*....|....*....|....*..
gi 729719230 138 -------LVWAISVTMIGVVLFDFAAD 157
Cdd:cd06176  104 alavlafLLYGIGVGAAGTAFLALLAD 130
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
29-157 2.46e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.50  E-value: 2.46e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  29 KRPTSRLIMHSMAMFGreFCYAVEAAYVTPVLLSV-GLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYIL 107
Cdd:COG2814  205 RRPRLLLLLLLAFLLG--FGFFALFTYLPLYLQEVlGLSASAAGLLLALFGLGGVLGALLAGRLAD----RFGRRRLLLI 278

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 729719230 108 TLgVMMLVGMALYLNGATVVAALIANprrkLVWAISVTMIGVVLFDFAAD 157
Cdd:COG2814  279 GL-LLLALGLLLLALAGSLWLLLLAL----FLLGFGFGLLFPLLQALVAE 323
PRK11462 PRK11462
putative transporter; Provisional
 64-130 1.27e-03

putative transporter; Provisional


Pssm-ID: 183145  Cd Length: 460  Bit Score: 39.53  E-value: 1.27e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 729719230  64 GLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYIL----TLGVMMLVGMA---LYLNGATVVAAL 130
Cdd:PRK11462  41 GIPAGFVGTMFLVARALDAISDPCMGLLADRTRSRWGKFRPWVLfgalPFGIVCVLAYStpdLSMNGKMIYAAI 114
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 39-157 6.18e-03

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 37.17  E-value: 6.18e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  39 SMAMFGREFCYAVeaayVTPVL----LSVGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRPYILTLGVMML 114
Cdd:cd17325    2 SLALFLDMLGYGI----IIPILplyaESLGASVAQIGLIVAAYALAQLLFSPPAGRLSD----RFGRKRLLLLGLLLLAV 73

                         90       100       110       120
                 ....*....|....*....|....*....|....*....|...
gi 729719230 115 VgMALYLNGATVVAALIAnprrKLVWAISVTMIGVVLFDFAAD 157
Cdd:cd17325   74 S-TLLFAFATSYWQLLLA----RFLQGLASAAVWPAAMALIAD 111
gph TIGR00792
sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH): ...
 55-107 8.38e-03

sugar (Glycoside-Pentoside-Hexuronide) transporter; The Glycoside-Pentoside-Hexuronide (GPH):Cation Symporter Family (TC 2.A.2) GPH:cation symporters catalyze uptake of sugars in symport with a monovalent cation (H+ or Na+). Members of this family includes transporters for melibiose, lactose, raffinose, glucuronides, pentosides and isoprimeverose. Mutants of two groups of these symporters (the melibiose permeases of enteric bacteria, and the lactose permease of Streptococcus thermophilus) have been isolated in which altered cation specificity is observed or in which sugar transport is uncoupled from cation symport (i.e., uniport is catalyzed). The various members of the family can use Na+, H+ or Li, Na+ or Li+, H+ or Li+, or only H+ as the symported cation. All of these proteins possess twelve putative transmembrane a-helical spanners. [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273270  Cd Length: 437  Bit Score: 36.84  E-value: 8.38e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 729719230   55 YVTPVLlsvGLPSSLYSIVWFLSPILGFLLQPVVGSASDHCRSRWGRRRPYIL 107
Cdd:TIGR00792  25 FYTDVL---GLSAAFVGTLFLVARILDAITDPIMGNIVDRTRTRWGKFRPWLL 74
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 63-180 9.21e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 36.82  E-value: 9.21e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 729719230  63 VGLPSSLYSIVWFLSPILGFLLQPVVGSASDhcrsRWGRRRpyiltlgvMMLVGMALylngATVVAALIAnprrkLVWAI 142
Cdd:cd17329   30 LGLSASIVGLVLALSAVAGIVASLIGGRLAD----RFGRKP--------VMLAGLLL----RALGFALLG-----FAHSP 88

                         90       100       110
                 ....*....|....*....|....*....|....*...
gi 729719230 143 SVTMIGVVLFDFAADFIDGPIKAYLFDVCSHQDKEKGL 180
Cdd:cd17329   89 WLFAIALVLTGFGGGLFEPASEAMIADVTTPENRTRAF 126
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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