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Conserved domains on  [gi|597436932|ref|NP_001277935|]
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leucine-rich repeat-containing protein 74B [Homo sapiens]

Protein Classification

leucine-rich repeat domain-containing protein( domain architecture ID 1006001)

leucine-rich repeat (LRR) domain-containing protein may participate in protein-protein interactions

CATH:  3.80.10.10
Gene Ontology:  GO:0005515
PubMed:  11751054|7583641|14747988
SCOP:  4003523

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
RNA1 super family cl34950
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-318 4.64e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


The actual alignment was detected with superfamily member COG5238:

Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 4.64e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  75 FLRQGSAQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQA 154
Cdd:COG5238  176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIA 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 155 LCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGP 234
Cdd:COG5238  256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 235 GAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQtLRILVVSRNP 314
Cdd:COG5238  336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNL 414


                 ....
gi 597436932 315 MRSE 318
Cdd:COG5238  415 IGAE 418
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-318 4.64e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 4.64e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  75 FLRQGSAQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQA 154
Cdd:COG5238  176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIA 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 155 LCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGP 234
Cdd:COG5238  256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 235 GAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQtLRILVVSRNP 314
Cdd:COG5238  336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNL 414


                 ....
gi 597436932 315 MRSE 318
Cdd:COG5238  415 IGAE 418
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 57-357 1.20e-37

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 138.26  E-value: 1.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  57 DTLYLRSCRAHSVVP-ISCFlrqgsaQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDN--GLCGAGAEALAGALSK 133
Cdd:cd00116    6 KGELLKTERATELLPkLLCL------QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 134 SSSIHDVDLSENQLGVAGAQALcAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHT-DLKSLDLSYNQLNDQAGETLG 212
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 213 PALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGA 292
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGA 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597436932 293 LSLGLGLR-VNQTLRILVVSRNPMRSEGCFGLLKSVQDNPasALELLDFSDIQVNAEFDGLASSVR 357
Cdd:cd00116  239 AALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE--SLLELDLRGNKFGEEGAQLLAESL 302
PLN03150 PLN03150
hypothetical protein; Provisional
 164-248 4.55e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 164 AMRKMQ---LSGNGLEEQAAQHLAELllahTDLKSLDLSYNQLNDQAGETLGpalaENTGLTELNVSWNHLRG--PGAVA 238
Cdd:PLN03150 440 KLRHLQsinLSGNSIRGNIPPSLGSI----TSLEVLDLSYNSFNGSIPESLG----QLTSLRILNLNGNSLSGrvPAALG 511

                         90
                 ....*....|
gi 597436932 239 fARGLEANIF 248
Cdd:PLN03150 512 -GRLLHRASF 520
 
Name Accession Description Interval E-value
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 75-318 4.64e-42

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 152.64  E-value: 4.64e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  75 FLRQGSAQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQA 154
Cdd:COG5238  176 ALQNNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEGVIA 255

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 155 LCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGP 234
Cdd:COG5238  256 LAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQ 335

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 235 GAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQtLRILVVSRNP 314
Cdd:COG5238  336 GAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNR-LHTLILDGNL 414


                 ....
gi 597436932 315 MRSE 318
Cdd:COG5238  415 IGAE 418
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 25-337 1.29e-39

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 146.09  E-value: 1.29e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  25 LSGVPEAEQGPEANWDSDLETEGTDGLGELVRDTLYLRSCRAHSVVPISC-----FLRQGSAQELNLRHRGLGPQGARAL 99
Cdd:COG5238   94 WEGAEEVSPVALAETATAVATPPPDLRRIMAKTLEDSLILYLALPRRINLiqvlkDPLGGNAVHLLGLAARLGLLAAISM 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 100 ASSLSsNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQALCAALTVNQAMRKMQLSGNGLEEQA 179
Cdd:COG5238  174 AKALQ-NNSVETVYLGCNQIGDEGIEELAEALTQNTTVTTLWLKRNPIGDEGAEILAEALKGNKSLTTLDLSNNQIGDEG 252

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 180 AQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGF 259
Cdd:COG5238  253 VIALAEALKNNTTVETLYLSGNQIGAEGAIALAKALQGNTTLTSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGI 332

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 597436932 260 GDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRNPMRSEGCFGLLKSVQDNPASALEL 337
Cdd:COG5238  333 GAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEGNTTLRELNLGKNNIGKQGAEALIDALQTNRLHTLIL 410
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 57-357 1.20e-37

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 138.26  E-value: 1.20e-37
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  57 DTLYLRSCRAHSVVP-ISCFlrqgsaQELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDN--GLCGAGAEALAGALSK 133
Cdd:cd00116    6 KGELLKTERATELLPkLLCL------QVLRLEGNTLGEEAAKALASALRPQPSLKELCLSLNetGRIPRGLQSLLQGLTK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 134 SSSIHDVDLSENQLGVAGAQALcAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHT-DLKSLDLSYNQLNDQAGETLG 212
Cdd:cd00116   80 GCGLQELDLSDNALGPDGCGVL-ESLLRSSSLQELKLNNNGLGDRGLRLLAKGLKDLPpALEKLVLGRNRLEGASCEALA 158

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 213 PALAENTGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGA 292
Cdd:cd00116  159 KALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGA 238

                        250       260       270       280       290       300
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 597436932 293 LSLGLGLR-VNQTLRILVVSRNPMRSEGCFGLLKSVQDNPasALELLDFSDIQVNAEFDGLASSVR 357
Cdd:cd00116  239 AALASALLsPNISLLTLSLSCNDITDDGAKDLAEVLAEKE--SLLELDLRGNKFGEEGAQLLAESL 302
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 77-344 5.34e-33

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 125.93  E-value: 5.34e-33
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  77 RQGSAQELNLR--HRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGAlSKSSSIHDVDLSENQLGVAGAQA 154
Cdd:cd00116   49 PQPSLKELCLSlnETGRIPRGLQSLLQGLTKGCGLQELDLSDNALGPDGCGVLESL-LRSSSLQELKLNNNGLGDRGLRL 127

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 155 LCAALTVNQ-AMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPALAENTGLTELNVSWNHLRG 233
Cdd:cd00116  128 LAKGLKDLPpALEKLVLGRNRLEGASCEALAKALRANRDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTD 207

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 234 PGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNV-LEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSR 312
Cdd:cd00116  208 EGASALAETLASLKSLEVLNLGDNNLTDAGAAALASALLSPNIsLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRG 287

                        250       260       270
                 ....*....|....*....|....*....|..
gi 597436932 313 NPMRSEGCFgLLKSVQDNPASALELLDFSDIQ 344
Cdd:cd00116  288 NKFGEEGAQ-LLAESLLEPGNELESLWVKDDS 318
LRR_RI cd00116
Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 ...
 58-285 1.99e-27

Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond to structural units consisting of a beta strand (LxxLxLxxN/CxL conserved pattern) and an alpha helix. This alignment contains 12 strands corresponding to 11 full repeats, consistent with the extent observed in the subfamily acting as Ran GTPase Activating Proteins (RanGAP1).


Pssm-ID: 238064 [Multi-domain]  Cd Length: 319  Bit Score: 110.52  E-value: 1.99e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  58 TLYLRSC--RAHSVVPISCFLRQGSAQELNLRHRGLGPQGARALASSL-SSNPYVKRLDLRDNGLCGAGAEALAGALSKS 134
Cdd:cd00116   85 ELDLSDNalGPDGCGVLESLLRSSSLQELKLNNNGLGDRGLRLLAKGLkDLPPALEKLVLGRNRLEGASCEALAKALRAN 164

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 135 SSIHDVDLSENQLGVAGAQALCAALTVNQAMRKMQLSGNGLEEQAAQHLAELLLAHTDLKSLDLSYNQLNDQAGETLGPA 214
Cdd:cd00116  165 RDLKELNLANNGIGDAGIRALAEGLKANCNLEVLDLNNNGLTDEGASALAETLASLKSLEVLNLGDNNLTDAGAAALASA 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 597436932 215 L-AENTGLTELNVSWNHLRGPGAVAFARGLEANIFLKVLDISYNGFGDPGASAVGEALKANNV-LEELNMSNN 285
Cdd:cd00116  245 LlSPNISLLTLSLSCNDITDDGAKDLAEVLAEKESLLELDLRGNKFGEEGAQLLAESLLEPGNeLESLWVKDD 317
RNA1 COG5238
Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ...
 82-215 1.68e-16

Ran GTPase-activating protein (RanGAP) involved in mRNA processing and transport [Translation, ribosomal structure and biogenesis];


Pssm-ID: 444072 [Multi-domain]  Cd Length: 434  Bit Score: 80.60  E-value: 1.68e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  82 QELNLRHRGLGPQGARALASSLSSNPYVKRLDLRDNGLCGAGAEALAGALSKSSSIHDVDLSENQLGVAGAQALCAALTV 161
Cdd:COG5238  295 TSLDLSVNRIGDEGAIALAEGLQGNKTLHTLNLAYNGIGAQGAIALAKALQENTTLHSLDLSDNQIGDEGAIALAKYLEG 374

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....
gi 597436932 162 NQAMRKMQLSGNGLEEQAAQHLAELLLaHTDLKSLDLSYNQLNDQAGETLGPAL 215
Cdd:COG5238  375 NTTLRELNLGKNNIGKQGAEALIDALQ-TNRLHTLILDGNLIGAEAQQRLEQLL 427
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
156-345 9.89e-12

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 66.11  E-value: 9.89e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 156 CAALTVNQAMRKMQLSGNGLEEqaaqhLAELLLAHTDLKSLDLSYNQLNDqagetLGPALAENTGLTELNVSWNHLRG-P 234
Cdd:COG4886  106 NEELSNLTNLESLDLSGNQLTD-----LPEELANLTNLKELDLSNNQLTD-----LPEPLGNLTNLKSLDLSNNQLTDlP 175

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 235 GAVAfarGLEAnifLKVLDISYNGFGDpgasaVGEALKANNVLEELNMSNNRISamgalSLGLGLRVNQTLRILVVSRNP 314
Cdd:COG4886  176 EELG---NLTN---LKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQ 239

                        170       180       190
                 ....*....|....*....|....*....|.
gi 597436932 315 MRSEGCFGLLKSvqdnpasaLELLDFSDIQV 345
Cdd:COG4886  240 LTDLPELGNLTN--------LEELDLSNNQL 262
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
101-345 3.94e-10

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 61.10  E-value: 3.94e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 101 SSLSSNPYVKRLDLRDNGLcgagaEALAGALSKSSSIHDVDLSENQLgvagaQALCAALTVNQAMRKMQLSGNGLEEqaa 180
Cdd:COG4886  107 EELSNLTNLESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNNQLTD--- 173

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 181 qhLAELLLAHTDLKSLDLSYNQLNDqagetLGPALAENTGLTELNVSWNHLRgpgavAFARGLEANIFLKVLDISYNGFG 260
Cdd:COG4886  174 --LPEELGNLTNLKELDLSNNQITD-----LPEPLGNLTNLEELDLSGNQLT-----DLPEPLANLTNLETLDLSNNQLT 241

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 261 DPgasavgEALKANNVLEELNMSNNRISamgALSLGLGLrvnQTLRILVVSRNPMRSEGCFGLLKSVQDNPASALELLDF 340
Cdd:COG4886  242 DL------PELGNLTNLEELDLSNNQLT---DLPPLANL---TNLKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLN 309


                 ....*
gi 597436932 341 SDIQV 345
Cdd:COG4886  310 LLELL 314
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-313 1.60e-09

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 59.18  E-value: 1.60e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  82 QELNLRHRGLgpqgaRALASSLSSNPYVKRLDLRDNGLcgagaEALAGALSKSSSIHDVDLSENQLgvagaQALCAALTV 161
Cdd:COG4886  116 ESLDLSGNQL-----TDLPEELANLTNLKELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNNQL-----TDLPEELGN 180

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 162 NQAMRKMQLSGNGLEEqAAQHLAELllahTDLKSLDLSYNQLNDqagetLGPALAENTGLTELNVSWNHLRGpgavafAR 241
Cdd:COG4886  181 LTNLKELDLSNNQITD-LPEPLGNL----TNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTD------LP 244

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|..
gi 597436932 242 GLEANIFLKVLDISYNGFGDpgasaVGEALKANNvLEELNMSNNRISAMGALSLGLGLRVNQTLRILVVSRN 313
Cdd:COG4886  245 ELGNLTNLEELDLSNNQLTD-----LPPLANLTN-LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNL 310
LRR COG4886
Leucine-rich repeat (LRR) protein [Transcription];
82-310 7.70e-07

Leucine-rich repeat (LRR) protein [Transcription];


Pssm-ID: 443914 [Multi-domain]  Cd Length: 414  Bit Score: 50.70  E-value: 7.70e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932  82 QELNLRHRGLgpqgaRALASSLSSNPYVKRLDLRDNGLcgagaEALAGALSKSSSIHDVDLSENQLgvagaQALCAALTV 161
Cdd:COG4886  139 KELDLSNNQL-----TDLPEPLGNLTNLKSLDLSNNQL-----TDLPEELGNLTNLKELDLSNNQI-----TDLPEPLGN 203

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 162 NQAMRKMQLSGNGLEEqaaqhLAELLLAHTDLKSLDLSYNQLNDQagetlgPALAENTGLTELNVSWNHLRGpgaVAFAR 241
Cdd:COG4886  204 LTNLEELDLSGNQLTD-----LPEPLANLTNLETLDLSNNQLTDL------PELGNLTNLEELDLSNNQLTD---LPPLA 269

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 597436932 242 GLEAnifLKVLDISYNGFGDPGASAVGEALKANNVLEELNMSNNRISAMGALSLGLGLRVNQTLRILVV 310
Cdd:COG4886  270 NLTN---LKTLDLSNNQLTDLKLKELELLLGLNSLLLLLLLLNLLELLILLLLLTTLLLLLLLLKGLLV 335
PLN03150 PLN03150
hypothetical protein; Provisional
 164-248 4.55e-04

hypothetical protein; Provisional


Pssm-ID: 178695 [Multi-domain]  Cd Length: 623  Bit Score: 42.50  E-value: 4.55e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 164 AMRKMQ---LSGNGLEEQAAQHLAELllahTDLKSLDLSYNQLNDQAGETLGpalaENTGLTELNVSWNHLRG--PGAVA 238
Cdd:PLN03150 440 KLRHLQsinLSGNSIRGNIPPSLGSI----TSLEVLDLSYNSFNGSIPESLG----QLTSLRILNLNGNSLSGrvPAALG 511

                         90
                 ....*....|
gi 597436932 239 fARGLEANIF 248
Cdd:PLN03150 512 -GRLLHRASF 520
PLN00113 PLN00113
leucine-rich repeat receptor-like protein kinase; Provisional
 132-249 2.54e-03

leucine-rich repeat receptor-like protein kinase; Provisional


Pssm-ID: 215061 [Multi-domain]  Cd Length: 968  Bit Score: 40.22  E-value: 2.54e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 132 SKSSSIHDVDLSENQLGVAGAQALcaaLTVNQAMrKMQLSGNGL------EEQAAQHLAELLLAHTDLKS---------- 195
Cdd:PLN00113 472 FGSKRLENLDLSRNQFSGAVPRKL---GSLSELM-QLKLSENKLsgeipdELSSCKKLVSLDLSHNQLSGqipasfsemp 547

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 597436932 196 ----LDLSYNQLNDQAGETLGPAlaenTGLTELNVSWNHLRG--PGAVAF----ARGLEANIFL 249
Cdd:PLN00113 548 vlsqLDLSQNQLSGEIPKNLGNV----ESLVQVNISHNHLHGslPSTGAFlainASAVAGNIDL 607
PPP1R42 cd21340
protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 ...
 165-290 8.82e-03

protein phosphatase 1 regulatory subunit 42; Protein phosphatase 1 regulatory subunit 42 (PPP1R42), also known as leucine-rich repeat-containing protein 67 (lrrc67) or testis leucine-rich repeat (TLRR) protein, plays a role in centrosome separation. PPP1R42 has been shown to interact with the well-conserved signaling protein phosphatase-1 (PP1) and thereby increasing PP1's activity, which counters centrosome separation. Inhibition of PPP1R42 expression increases the number of centrosomes per cell while its depletion reduces the activity of PP1 leading to activation of NEK2, the kinase responsible for phosphorylation of centrosomal linker proteins promoting centrosome separation.


Pssm-ID: 411060 [Multi-domain]  Cd Length: 220  Bit Score: 37.46  E-value: 8.82e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 597436932 165 MRKMQLSGN------GLEEQaaqhlaelllahTDLKSLDLSYNQLndQAGETL--GP----ALAENtgLTELNVSWNHLR 232
Cdd:cd21340   70 LKKLYLGGNrisvveGLENL------------TNLEELHIENQRL--PPGEKLtfDPrslaALSNS--LRVLNISGNNID 133

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 597436932 233 GPGAVAFARGLEaniflkVLDISYNGFGDpgASAVGEALKANNVLEELNMSNNRISAM 290
Cdd:cd21340  134 SLEPLAPLRNLE------QLDASNNQISD--LEELLDLLSSWPSLRELDLTGNPVCKK 183
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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