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Conserved domains on  [gi|586946418|ref|NP_001276953|]
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interleukin-12 receptor subunit beta-1 isoform 4 [Homo sapiens]

Protein Classification

fibronectin type III domain-containing protein( domain architecture ID 10045852)

fibronectin type III (FN3) domain-containing protein may be involved in specific interactions with other molecules through its FN3 domain

CATH:  2.60.40.10
Gene Ontology:  GO:0005515
PubMed:  19576999|9837732|8981327

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 487-577 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


:

Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946418 487 GTPHHVSVKNHSLDSVSVDWAPSLLSTCPgvLKEYVVRCRDEDSKQVSEHPVQP-TETQVTLSGLRAGVAYTVQVRADTA 565
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGP--ITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|..
gi 586946418 566 WLRGVWSQPQRF 577
Cdd:cd00063   80 GGESPPSESVTV 91
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 487-577 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946418 487 GTPHHVSVKNHSLDSVSVDWAPSLLSTCPgvLKEYVVRCRDEDSKQVSEHPVQP-TETQVTLSGLRAGVAYTVQVRADTA 565
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGP--ITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|..
gi 586946418 566 WLRGVWSQPQRF 577
Cdd:cd00063   80 GGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
489-572 9.33e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 9.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946418  489 PHHVSVKNHSLDSVSVDWAPSllSTCPGVLKEYVVRCRDEDSKQVSEH-PVQPTETQVTLSGLRAGVAYTVQVRADTAWL 567
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWNEiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 586946418  568 RGVWS 572
Cdd:pfam00041  81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 487-562 8.86e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 8.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586946418   487 GTPHHVSVKNHSLDSVSVDWAPSLLSTCPGVLKEYVVRCRDEDSKQVsEHPVQPTETQVTLSGLRAGVAYTVQVRA 562
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
 
Name Accession Description Interval E-value
FN3 cd00063
Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein ...
 487-577 1.75e-12

Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all animal proteins contain the FN3 repeat; including extracellular and intracellular proteins, membrane spanning cytokine receptors, growth hormone receptors, tyrosine phosphatase receptors, and adhesion molecules. FN3-like domains are also found in bacterial glycosyl hydrolases.


Pssm-ID: 238020 [Multi-domain]  Cd Length: 93  Bit Score: 63.67  E-value: 1.75e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946418 487 GTPHHVSVKNHSLDSVSVDWAPSLLSTCPgvLKEYVVRCRDEDSKQVSEHPVQP-TETQVTLSGLRAGVAYTVQVRADTA 565
Cdd:cd00063    2 SPPTNLRVTDVTSTSVTLSWTPPEDDGGP--ITGYVVEYREKGSGDWKEVEVTPgSETSYTLTGLKPGTEYEFRVRAVNG 79

                         90
                 ....*....|..
gi 586946418 566 WLRGVWSQPQRF 577
Cdd:cd00063   80 GGESPPSESVTV 91
fn3 pfam00041
Fibronectin type III domain;
489-572 9.33e-10

Fibronectin type III domain;


Pssm-ID: 394996 [Multi-domain]  Cd Length: 85  Bit Score: 55.50  E-value: 9.33e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 586946418  489 PHHVSVKNHSLDSVSVDWAPSllSTCPGVLKEYVVRCRDEDSKQVSEH-PVQPTETQVTLSGLRAGVAYTVQVRADTAWL 567
Cdd:pfam00041   3 PSNLTVTDVTSTSLTVSWTPP--PDGNGPITGYEVEYRPKNSGEPWNEiTVPGTTTSVTLTGLKPGTEYEVRVQAVNGGG 80


                  ....*
gi 586946418  568 RGVWS 572
Cdd:pfam00041  81 EGPPS 85
FN3 smart00060
Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, ...
 487-562 8.86e-09

Fibronectin type 3 domain; One of three types of internal repeat within the plasma protein, fibronectin. The tenth fibronectin type III repeat contains a RGD cell recognition sequence in a flexible loop between 2 strands. Type III modules are present in both extracellular and intracellular proteins.


Pssm-ID: 214495 [Multi-domain]  Cd Length: 83  Bit Score: 53.00  E-value: 8.86e-09
                           10        20        30        40        50        60        70
                   ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 586946418   487 GTPHHVSVKNHSLDSVSVDWAPSLLSTCPGVLKEYVVRCRDEDSKQVsEHPVQPTETQVTLSGLRAGVAYTVQVRA 562
Cdd:smart00060   2 SPPSNLRVTDVTSTSVTLSWEPPPDDGITGYIVGYRVEYREEGSEWK-EVNVTPSSTSYTLTGLKPGTEYEFRVRA 76
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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