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Conserved domains on  [gi|584277117|ref|NP_001276869|]
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excitatory amino acid transporter 1 isoform 5 [Homo sapiens]

Protein Classification

dicarboxylate/amino acid:cation symporter( domain architecture ID 10003465)

dicarboxylate/amino acid:cation symporter facilitates H+ or Na+ symport with C4-dicarboxylates, dicarboxylic amino acids (aspartate, glutamate) or other amino acids; belongs to the sodium:dicarboxylate symporter family

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-384 7.88e-96

Na+/H+-dicarboxylate symporter [Energy production and conversion];


:

Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 293.56  E-value: 7.88e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTA---ADAFLDLI--------------------------- 174
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEApslLDFLLNIIpsnifeafaegnmlqiiffailfgial 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 175 -----------------------------RYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLY 225
Cdd:COG1301  156 aalgekgkplldffeslsevmfkivgwvmKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLIL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 226 FLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVN 305
Cdd:COG1301  234 RLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAY 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 584277117 306 NFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 384
Cdd:COG1301  314 GIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-384 7.88e-96

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 293.56  E-value: 7.88e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTA---ADAFLDLI--------------------------- 174
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEApslLDFLLNIIpsnifeafaegnmlqiiffailfgial 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 175 -----------------------------RYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLY 225
Cdd:COG1301  156 aalgekgkplldffeslsevmfkivgwvmKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLIL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 226 FLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVN 305
Cdd:COG1301  234 RLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAY 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 584277117 306 NFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 384
Cdd:COG1301  314 GIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
50-385 1.70e-90

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 279.02  E-value: 1.70e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117   50 FVLLTVTAVIVGTILGFTLRPYRMsyrevkYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYM 128
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPELAA------WLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  129 TTTIIAVVIGIIIVIIIHPGKGTKeNMHREGKIVRVTAADAFLDLI---------------------------------- 174
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFIlniipsnifealaegnvlavivfailfgialaal 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  175 --------------------------RYAPVGILFLIAGKIVEmEDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLV 228
Cdd:pfam00375 154 gekgepllnfieslqevmmkvigwvmKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  229 TRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE 308
Cdd:pfam00375 232 GKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVD 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 584277117  309 LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHL 385
Cdd:pfam00375 312 LSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 57-377 1.65e-29

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 119.10  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  57 AVIVGTILGFTLRpYRMSYRE---VKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYMTTTI 132
Cdd:PRK11283  15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 133 IAVVIGIIIVIIIHPGKG----------------TKENMHREG-------------KIVRVTAADAFLDLI--------- 174
Cdd:PRK11283  94 VAIILGITLANVFQPGAGidmsqlatvdiskyqsTTEEVQSHShglmgtilsliptNIFASMAKGEMLPIIffsvlfglg 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 175 -------------------------------RYAPVGILFLIAGKIVEMEDMGVIggQLAMYTVTVIVGLLIHAVIVLPL 223
Cdd:PRK11283 174 lsslpathreplvtvfrsvsetmfkvthmvmRYAPVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGI 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 224 LYFLVtRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENnGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQ 303
Cdd:PRK11283 252 VARLC-GLSIWILIRILKDELILAYSTASSETVLPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQ 329

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 584277117 304 VNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL 377
Cdd:PRK11283 330 LYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNAL 403
 
Name Accession Description Interval E-value
GltP COG1301
Na+/H+-dicarboxylate symporter [Energy production and conversion];
46-384 7.88e-96

Na+/H+-dicarboxylate symporter [Energy production and conversion];


Pssm-ID: 440912 [Multi-domain]  Cd Length: 406  Bit Score: 293.56  E-value: 7.88e-96
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  46 FRNAFVLLTVTAVIVGTILGFTLRPYrmsyrEVKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAV 124
Cdd:COG1301    1 FKLSLTLQILIALVLGILLGLLLPEL-----VAAVLKPLGDIFINLLKMIVVPLVFFSIVVGIASLgDLKKLGRIGGKTL 75

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 125 VYYMTTTIIAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTA---ADAFLDLI--------------------------- 174
Cdd:COG1301   76 LYFLVTTTIALVIGLVVANLFQPGAGLNLDLADAAAAEAAEApslLDFLLNIIpsnifeafaegnmlqiiffailfgial 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 175 -----------------------------RYAPVGILFLIAGKIVEMeDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLY 225
Cdd:COG1301  156 aalgekgkplldffeslsevmfkivgwvmKLAPIGVFALIAATVAKY-GLDALG-SLGKLVLTVYLALLLHLFVVLPLIL 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 226 FLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVN 305
Cdd:COG1301  234 RLLTGLSPLKFLRAIRPALLLAFSTSSSEATLPVTMEKAEEKLGVSKSVASFVLPLGATINMDGTAIYQAVAALFIAQAY 313

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 584277117 306 NFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEH 384
Cdd:COG1301  314 GIDLSLGQQLTIVLTAVLASIGAAGVPGAGLVMLAAVLSAVGLPLEGIALILGIDRILDMARTAVNVTGDAVATVVVAK 392
SDF pfam00375
Sodium:dicarboxylate symporter family;
50-385 1.70e-90

Sodium:dicarboxylate symporter family;


Pssm-ID: 425646 [Multi-domain]  Cd Length: 388  Bit Score: 279.02  E-value: 1.70e-90
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117   50 FVLLTVTAVIVGTILGFTLRPYRMsyrevkYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYM 128
Cdd:pfam00375   1 LLLQILIALVLGILIGLFFPELAA------WLKPLGDLFIRLLKMIIVPLIFASIISGIASLgDGKKLGKLGGKTLLYFL 74

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  129 TTTIIAVVIGIIIVIIIHPGKGTKeNMHREGKIVRVTAADAFLDLI---------------------------------- 174
Cdd:pfam00375  75 VTTAIAALIGLLVANVFQPGSGLA-LIAASLKEAKAAEAPSLLDFIlniipsnifealaegnvlavivfailfgialaal 153

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  175 --------------------------RYAPVGILFLIAGKIVEmEDMGVIGgQLAMYTVTVIVGLLIHAVIVLPLLYFLV 228
Cdd:pfam00375 154 gekgepllnfieslqevmmkvigwvmKLAPIGVFALIANTVGT-YGLGILS-SLAKFLLVVYLGLAIHLLIVYPLLIKFL 231

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  229 TRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFE 308
Cdd:pfam00375 232 GKVNPFKFLKKMLPALLTAFSTASSAATLPVTLECAEKNLGVSESIASFVLPLGATINMDGTAIYLAVAAIFIAQAYGVD 311

                         330       340       350       360       370       380       390
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 584277117  309 LNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSLGAGIVEHL 385
Cdd:pfam00375 312 LSFGQQLTLVLTATLASIGAAGVPGGGLVALGLVLSALGLPLEGIALILAIDRLLDMFRTAVNVTGDAAAAVIVAKL 388
gltP PRK11283
glutamate/aspartate:proton symporter; Provisional
 57-377 1.65e-29

glutamate/aspartate:proton symporter; Provisional


Pssm-ID: 183075 [Multi-domain]  Cd Length: 437  Bit Score: 119.10  E-value: 1.65e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  57 AVIVGTILGFTLRpYRMSYRE---VKYFSFPGELLMRMLQMLVLPLIISSLVTGMAAL-DSKASGKMGMRAVVYYMTTTI 132
Cdd:PRK11283  15 ALVLGILLGAYLH-YHSDSRDwlvSNLLSPAGDIFIHLIKMIVVPIVISTLIVGIAGVgDAKQLGRIGAKTIIYFEVITT 93

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 133 IAVVIGIIIVIIIHPGKG----------------TKENMHREG-------------KIVRVTAADAFLDLI--------- 174
Cdd:PRK11283  94 VAIILGITLANVFQPGAGidmsqlatvdiskyqsTTEEVQSHShglmgtilsliptNIFASMAKGEMLPIIffsvlfglg 173

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 175 -------------------------------RYAPVGILFLIAGKIVEMEDMGVIggQLAMYTVTVIVGLLIHAVIVLPL 223
Cdd:PRK11283 174 lsslpathreplvtvfrsvsetmfkvthmvmRYAPVGVFALIAVTVANFGFASLW--PLAKLVLLVYFAILFFALVVLGI 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 224 LYFLVtRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENnGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQ 303
Cdd:PRK11283 252 VARLC-GLSIWILIRILKDELILAYSTASSETVLPRIIEKMEAY-GAPKSITSFVVPTGYSFNLDGSTLYQSIAAIFIAQ 329

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 584277117 304 VNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLRTTTNVLGDSL 377
Cdd:PRK11283 330 LYGIDLSIWQEIILVLTLMVTSKGIAGVPGVSFVVLLATLGSVGIPLEGLAFIAGVDRILDMARTALNVVGNAL 403
PRK13027 PRK13027
C4-dicarboxylate transporter DctA; Reviewed
 42-375 2.34e-29

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 183850 [Multi-domain]  Cd Length: 421  Bit Score: 118.62  E-value: 2.34e-29
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  42 KSYLFRNAFVLLtVTAVIVGTILGFTLRPYRMSYREVkyfsfpGELLMRMLQMLVLPLIISSLVTGMA-ALDSKASGKMG 120
Cdd:PRK13027   1 MKKFLRSLFGQV-VIALVLGVALGAFFPHFAESLKPL------GDGFIKLIKMLIGPIVFCVVVSGIAgAGDLKKVGRVG 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 121 MRAVVYYMTTTIIAVVIGIIIVIIIHPGKG----------------TKENMHREG------KIVRVTAADAF-------- 170
Cdd:PRK13027  74 LKAVIYFEVMTTIALVIGLVLAYLTGPGVGmnidlrsldaaslagyAKNAQSLKGtagfllKLIPTTAVDAFakgdilqv 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 171 ----------LDLI--RYAPVG--------ILFLIAGKIVEMEDMGVIGG--------------QLAMYTVTVIVGLLIH 216
Cdd:PRK13027 154 llfsvlfgsaLSLLgeRAKRVNrlidelshVLFRIMGFIIKLAPLGVLGAiafttgkygvgslkQLGMLVAVFYLTCFVF 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 217 AVIVLPLLYFLvTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEeNNGVDKRVTRFVLPVGATINMDGTALYEAL 296
Cdd:PRK13027 234 VVVVLGAVMRL-AGFSVFKLIRYLREELLIVLGTASSDAVLPQVMRKLE-HMGIKDSTVGLVIPTGYSFNLDGFSIYLTL 311

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 297 AAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWFLDRLRTTTNVLGD 375
Cdd:PRK13027 312 AAVFIAQATNTPLSMHDLITILLVSLVTSKGAHGIPGSAIVILAATLSAIPaIPVLGLVLILPVDWFMGIARALTNLIGN 391
PRK01663 PRK01663
C4-dicarboxylate transporter DctA; Reviewed
 42-374 1.73e-27

C4-dicarboxylate transporter DctA; Reviewed


Pssm-ID: 234968 [Multi-domain]  Cd Length: 428  Bit Score: 113.46  E-value: 1.73e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  42 KSYLFRNAFVLLtVTAVIVGTILGF-------TLRPYrmsyrevkyfsfpGELLMRMLQMLVLPLIISSLVTGMAAL-DS 113
Cdd:PRK01663   2 KKPLYKSLYFQV-LVAIIIGILLGHfypelgaQMKPL-------------GDGFIKLIKMIIAPIIFCTVVTGIAGMgDM 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 114 KASGKMGMRAVVYYMTTTIIAVVIGIIIVIIIHPGKGT---------------KENMHREG------KIVRVTAADAF-- 170
Cdd:PRK01663  68 KKVGRVGGKALLYFEIVSTIALIIGLIVVNVVQPGAGMnidpatldakavaqyAAQAHEQGtvdflmDIIPTTVVGAFas 147

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 171 ----------------LDLI--RYAPV--------GILFLIAGKIVEMEDMGVIGG--------------QLAMYTVTVI 210
Cdd:PRK01663 148 gdilqvllfavlfgfaLARLgeKGKPVfdfieslsHVLFGIVNMIMKLAPIGAFGAmaftigkygvgslvQLGQLIGCFY 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 211 VGLLIHAVIVLPLlyflVTRK---NPWVFIGGLLQALITALGTSSSSATLPITFKCLEeNNGVDKRVTRFVLPVGATINM 287
Cdd:PRK01663 228 ITCILFVFVVLGA----IARLtgfSIFKFIRYIKEELLIVLGTSSSESALPRMMEKME-KLGCKKSVVGLVIPTGYSFNL 302

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 288 DGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGAAGIPQAGLVTMVIVLTSVG-LPTDDITLIIAVDWFLDRL 366
Cdd:PRK01663 303 DGTSIYLTMAAVFIAQATNTPLSIGHQITLLAVLLLTSKGAAGVTGSGFIVLAATLSAVPhIPVAGLALILGIDRFMSEA 382


                 ....*...
gi 584277117 367 RTTTNVLG 374
Cdd:PRK01663 383 RALTNLIG 390
PRK13628 PRK13628
serine/threonine transporter SstT; Provisional
 160-331 7.41e-13

serine/threonine transporter SstT; Provisional


Pssm-ID: 184190 [Multi-domain]  Cd Length: 402  Bit Score: 69.51  E-value: 7.41e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 160 KIVRVtaadafldLIRYAPVGILFLIAGKIVEMEDMGVIG-GQLAMytvtVIVG-LLIHAVIVLPLLYFLVTRKNPW--V 235
Cdd:PRK13628 181 QIVKW--------VIRFAPIGIFGLVASTLAETGFSALAGyAQLLA----VLVGcMLFVALVVNPLIVFWKIRRNPYplV 248

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 236 FIgGLLQALITALGTSSSSATLPITFKcLEENNGVDKRVTRFVLPVGATINMDGtalyealAAIFI-----AQVNNF--E 308
Cdd:PRK13628 249 FT-CLRESGVTAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMAG-------AAITItvltlAAVHTLgiP 319

                        170       180
                 ....*....|....*....|...
gi 584277117 309 LNFGQIITISITATAASIGAAGI 331
Cdd:PRK13628 320 VDLPTALLLSVVAAISACGASGV 342
PRK14695 PRK14695
serine/threonine transporter SstT; Provisional
 173-384 2.24e-12

serine/threonine transporter SstT; Provisional


Pssm-ID: 173158  Cd Length: 319  Bit Score: 67.77  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 173 LIRYAPVGILFLIAGKIvemEDMGVigGQLAMY---TVTVIVGLLIHAVIVLPLLYFLVTRKNPWVFIGGLLQ-ALITAL 248
Cdd:PRK14695 100 IINLAPFGILGLVFKTI---SDKGV--GSLANYgilLVLLVTTMLFVAPVVNPLIAFFFMRRNPYPLVWNCLRvSGVTAF 174

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 249 GTSSSSATLPITFKcLEENNGVDKRVTRFVLPVGATINMDGTALYEALAAIFIAQVNNFELNFGQIITISITATAASIGA 328
Cdd:PRK14695 175 FTRSSATNIPVNMK-LCHDLGLNPDTYSVSIPLGSTINMAGVAITINLLTLVTVNTLGIPVDFATAFVLSVVAAISACGA 253

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 329 AGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFL----DRLRTTTNVLGDSLGAGIVEH 384
Cdd:PRK14695 254 SGIAGGSLLLIPVACSLFGISNDIAIQIVGVGFVIgviqDSCETALNSSTDVLFTAVAEY 313
SstT COG3633
Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];
160-332 2.24e-12

Na+/serine and Na+/threonine symporter SstT [Amino acid transport and metabolism];


Pssm-ID: 442850  Cd Length: 406  Bit Score: 68.27  E-value: 2.24e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 160 KIVRVtaadafldLIRYAPVGILFLIAGKIVEMedmGVigGQLAMYT--VTVIVG-LLIHAVIVLPLLYFLVTRKNPW-- 234
Cdd:COG3633  180 KIVRW--------VIRFAPLGIFGLVASTVATT---GF--SALLGYAhlLAVLVGcMLFVALVVNPLIVFLKIRRNPYpl 246

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 235 VFIGgLLQALITALGTSSSSATLPITFKcLEENNGVDKRVTRFVLPVGATINMDGtalyealAAIFI-----AQVN--NF 307
Cdd:COG3633  247 VFTC-LRESGITAFFTRSSAANIPVNMA-LCEKLGLDEDTYSVSIPLGATINMAG-------AAITItvltlAAVHtlGI 317

                        170       180
                 ....*....|....*....|....*
gi 584277117 308 ELNFGQIITISITATAASIGAAGIP 332
Cdd:COG3633  318 EVDLPTALLLSVVAAVSACGASGVA 342
TcyP COG1823
L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and ...
 56-382 1.61e-09

L-cystine transporter TcyP, sodium:dicarboxylate symporter family [Amino acid transport and metabolism];


Pssm-ID: 441428  Cd Length: 463  Bit Score: 59.45  E-value: 1.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117  56 TAVIVGTILGFTLR-PYRMSYREVK----YFSFPGELLMRMLQMLVLPLIISSLVTGMAALDSKAS-GKMGMRAVVYYMT 129
Cdd:COG1823   36 TGLGLGILFGLILQlIYGAGSPVIKqsidWFNIVGNGYVRLLQMIVMPLVFVSILSAITKLKNASSlGKISGLIIGILLG 115

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 130 TTI--------------------IAVVIGIIIVIIIHPGKGTKENMHREGKIVRVTAADAFLDL---------------- 173
Cdd:COG1823  116 TTAiaalvgilvallfgltaeglTQGAAETARGEALEERLGEVEDLSLPQQILSFIPTNPFADLtgarptstiavvifaa 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 174 --------------------------------------IRYAPVGILFLIAgKIVEMEDMGVI----GGQLAMYtVTVIV 211
Cdd:COG1823  196 flgiaalglrrkkpeqaetflkgidalqaivmrlvrlvLRLTPYGVLALMT-KVVATSDFADIlnlgKFVVASY-VALII 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 212 GLLIHAVIVlpllyfLVTRKNPWVFIGGLLQALITALGTSSSSATLPITFKCLEENNGVDKRVTRFVLPVGATINMDGTA 291
Cdd:COG1823  274 MFIVHLLLL------ALAGLNPLTYFKKVWPVLTFAFTSRSSAGTIPLNIETQTKRLGVPEGIANFAASFGATIGQNGCA 347

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 584277117 292 -LYEALAAIFIAQ---VNNFELNFgqIITISITATAASIGAAGIPQAGLVTMVIVLTSVGLPTDDITLIIAVDWFLDRLR 367
Cdd:COG1823  348 gIYPAMLAVMIAPtvgINPLDPSF--ILTLIAVVTISSFGVAGVGGGATFAALIVLSAMGLPVALAGLLISIEPLIDMGR 425

                        410
                 ....*....|....*
gi 584277117 368 TTTNVlGDSLGAGIV 382
Cdd:COG1823  426 TALNV-SGSMTAGTV 439
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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