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isocitrate dehydrogenase [NADP], mitochondrial isoform 2 [Homo sapiens]
Protein Classification
NADP-dependent isocitrate dehydrogenase ( domain architecture ID 10015366 )
NADP-dependent isocitrate dehydrogenase catalyzes the conversion of isocitrate to 2-oxoglutarate in an NADP-dependent manner
List of domain hits
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-399
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 841.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITPDEARV E EF K LKKMW 80
Cdd:PTZ00435 15 L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITPDEARV K EF N LKKMW 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP K DGS GVKEWE V YN F 160
Cdd:PTZ00435 95 KSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP A DGS EPQRVD V FD F 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F D K NKI WYEHRLIDD 240
Cdd:PTZ00435 175 KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F E K AGL WYEHRLIDD 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 241 MVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E HQKG RP TSTN P IASI 320
Cdd:PTZ00435 255 MVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q HQKG KE TSTN S IASI 334
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 583966148 321 FAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L D TIKSN L DRA LG R 399
Cdd:PTZ00435 335 FAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I D KVAEK L KKK LG A 412
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-399
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 841.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITPDEARV E EF K LKKMW 80
Cdd:PTZ00435 15 L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITPDEARV K EF N LKKMW 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP K DGS GVKEWE V YN F 160
Cdd:PTZ00435 95 KSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP A DGS EPQRVD V FD F 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F D K NKI WYEHRLIDD 240
Cdd:PTZ00435 175 KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F E K AGL WYEHRLIDD 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 241 MVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E HQKG RP TSTN P IASI 320
Cdd:PTZ00435 255 MVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q HQKG KE TSTN S IASI 334
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 583966148 321 FAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L D TIKSN L DRA LG R 399
Cdd:PTZ00435 335 FAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I D KVAEK L KKK LG A 412
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
1-397
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 686.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MDGDEMTRIIW QF IK E KLILP H V DIQ LKY F DLG LPN RD Q T D DQVT I D S A L A TQ KY S V A VKCATITPDEARVEEFKLKKMW 80
Cdd:TIGR00127 12 MDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A T N DQVT V D A A E A IK KY N V G VKCATITPDEARVEEFKLKKMW 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFV ADRA G TFKM V FT PKDG SGVKEWE VY N F 160
Cdd:TIGR00127 92 KSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFV VPGP G KLEL V YK PKDG TQKVTLK VY D F 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 P - A GGV G M G MYNTDESI S GFAHS C FQ Y A IQ KKWPLY M STKNTILK A YDGRFKDIFQE IFDKH YK TD F DKNK IWYEHRLID 239
Cdd:TIGR00127 172 E e G GGV A M A MYNTDESI E GFAHS S FQ L A LE KKWPLY L STKNTILK K YDGRFKDIFQE VYEAQ YK SK F EALG IWYEHRLID 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 240 DMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QKG RP TSTN P IAS 319
Cdd:TIGR00127 252 DMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QKG QE TSTN S IAS 331
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 583966148 320 IFAW T RGL E HR G KLD G N QD L IR FA QM LE KV C VE TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D TIKSN L DRAL 397
Cdd:TIGR00127 332 IFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D AVEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
1-395
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 525.83
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MD GD ---- E M TR I IW QF I KEKLILPH --- V DI QL K YF D L G LPN RD Q T D D QVTIDS A L A TQK Y S V AV K CATI TP DEA rvee 73
Cdd:COG0538 24 IE GD gigp E I TR A IW KV I DAAVEKAY ggk R DI EW K EV D A G EKA RD E T G D WLPDET A E A IKE Y G V GI K GPLT TP VGG ---- 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 74 fklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATDFV A DRAGTF K MV F TPK D GS G 151
Cdd:COG0538 100 ----- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIEWK A GSPEAL K LI F FLE D EM G 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 152 V kew E V YN FP AG - G V G MGMYN t DE SISGFAHSCF QYA IQ - K KWPLYMST K NT I L K AYD G R FKD IFQ E IFDKHYKTD F --- 226
Cdd:COG0538 175 V --- T V IR FP ED s G I G IKPVS - DE GTERLVRAAI QYA LD n K RKSVTLVH K GN I M K FTE G A FKD WGY E VAEEEFGDK F ite 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 227 ---------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S LG LMTSVLVCP DG K t I E A EA A 295
Cdd:COG0538 251 gpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G LG IAPGANIGD DG G - A E F EA T 329
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 296 HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QML EK VCVE T V ESG AM T K DLA GCIH G lsnvkl 375
Cdd:COG0538 330 HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I ESG KV T Y DLA RLME G ------ 390
410 420
....*....|....*....|
gi 583966148 376 n EHF L N T TD F L D T I KS NLD R 395
Cdd:COG0538 391 - ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
1-389
7.47e-91
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 277.64
E-value: 7.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MD G D E MTRIIWQFI K EK L ILPHVDIQLKYF D L G LPNR D Q T DDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- EA R V E EF k L 76
Cdd:pfam00180 9 GI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa GV R P E NG - L 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 77 KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATD fvadragtfkmvf TPKD GSG VK ewe 156
Cdd:pfam00180 88 LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIE ------------- KGIK GSG NE --- 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 157 vynfpa GG V GMGM Y NT DE s I SGF A HSC F QY A IQK - KWPLYMST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfdkn KIWY EH 235
Cdd:pfam00180 149 ------ VA V DTKL Y SR DE - I ERI A RVA F EL A RKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVEL EH 214
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 236 R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREHQ kgrpts T 314
Cdd:pfam00180 215 Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI ------ A 287
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 583966148 315 NPIA S I FAWTRG L EHRGK L DGN qdlirf A QML E KVCVETV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F LDTI 389
Cdd:pfam00180 288 NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F GEAV 346
Name
Accession
Description
Interval
E-value
PTZ00435
PTZ00435 isocitrate dehydrogenase; Provisional
1-399
0e+00
isocitrate dehydrogenase; Provisional
Pssm-ID: 240417
Cd Length: 413
Bit Score: 841.19
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 M DGDEMTRIIW QF IKEKLILP HV D IQL KY F DL GLP NRD Q TDD Q VT I D S A L A TQ K YS V AV KCATITPDEARV E EF K LKKMW 80
Cdd:PTZ00435 15 L DGDEMTRIIW KM IKEKLILP YL D VPI KY Y DL SIE NRD K TDD K VT V D A A E A IK K HK V GI KCATITPDEARV K EF N LKKMW 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNIL G GTVFREPII C KNIPRLVPGW T KPI T IGRHA H GDQYKATDFV A D RA G TFKM VFTP K DGS GVKEWE V YN F 160
Cdd:PTZ00435 95 KSPNGTIRNIL D GTVFREPII I KNIPRLVPGW K KPI V IGRHA F GDQYKATDFV V D GP G KLEL VFTP A DGS EPQRVD V FD F 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 PA GGV G MGMYNTDESI S GFA H SCFQYA IQK K W PLY M STKNTILK A YDGRFKDIFQEI F D KH YK TD F D K NKI WYEHRLIDD 240
Cdd:PTZ00435 175 KG GGV A MGMYNTDESI E GFA R SCFQYA LDR K M PLY L STKNTILK K YDGRFKDIFQEI Y D EE YK AK F E K AGL WYEHRLIDD 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 241 MVAQ VL KS S GGFVWACKNYDGDVQSDI L AQG F GSLGLMTSVLVCPDGKT I EAEAAHGTVTRHYR E HQKG RP TSTN P IASI 320
Cdd:PTZ00435 255 MVAQ AI KS E GGFVWACKNYDGDVQSDI V AQG Y GSLGLMTSVLVCPDGKT V EAEAAHGTVTRHYR Q HQKG KE TSTN S IASI 334
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 583966148 321 FAWTRGL E HR G KLD G NQ D L IR F A Q M LE KV C V ET V E S G A MTKDLA G C I HG L S N V K l NEHF LNT TD F L D TIKSN L DRA LG R 399
Cdd:PTZ00435 335 FAWTRGL A HR A KLD N NQ E L VK F C Q A LE RS C I ET I E A G F MTKDLA I C V HG S S K V T - RSDY LNT EE F I D KVAEK L KKK LG A 412
PRK08299
PRK08299 NADP-dependent isocitrate dehydrogenase;
1-397
0e+00
NADP-dependent isocitrate dehydrogenase;
Pssm-ID: 236226
Cd Length: 402
Bit Score: 819.87
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 M DGDEMTRIIW Q FIK E KLILP HV DI Q L K Y F DLG LP NRD Q TDDQVTID S A L A TQ KY S V A VKCATITPDEARV E EF K LKKMW 80
Cdd:PRK08299 13 L DGDEMTRIIW K FIK D KLILP YL DI D L E Y Y DLG IE NRD A TDDQVTID A A N A IK KY G V G VKCATITPDEARV K EF N LKKMW 92
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNILGGTVFREPIICKN I PRLVPGWTKPI T IGRHA H GDQY K ATDF VADRA G TFKM VFT PK DG S g VK E W EV YN F 160
Cdd:PRK08299 93 KSPNGTIRNILGGTVFREPIICKN V PRLVPGWTKPI V IGRHA Y GDQY R ATDF KVPGK G KLTL VFT GE DG E - PI E H EV HD F 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 P AG GV G MGMYN T DESI SG FA HSC F Q Y AIQK K W P L Y M STKNTILKAYDGRFKDIFQE IFDKHY K TD F DKNK I W YEHRLIDD 240
Cdd:PRK08299 172 P GA GV A MGMYN L DESI RD FA RAS F N Y GLDR K Y P V Y L STKNTILKAYDGRFKDIFQE VYEAEF K EK F EAAG I T YEHRLIDD 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 241 MVA QV LK SS GG F VWACKNYDGDVQSD IL AQGFGSLGLMTSVL VC PDGKT I EAEAAHGTVTRHYR E HQKG RP TSTNPIASI 320
Cdd:PRK08299 252 MVA SA LK WE GG Y VWACKNYDGDVQSD TV AQGFGSLGLMTSVL MT PDGKT V EAEAAHGTVTRHYR Q HQKG EE TSTNPIASI 331
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 583966148 321 FAWTRGL E HRGKLDGN QD L IR FA QM LEKVC V ETVESG A MTKDLA GCIHG lsnvkl NEHF L N T TD FLD T I KS NL DR AL 397
Cdd:PRK08299 332 FAWTRGL A HRGKLDGN PE L VK FA DT LEKVC I ETVESG F MTKDLA LLVGP ------ DQKW L T T EE FLD A I DE NL EK AL 402
PLN03065
PLN03065 isocitrate dehydrogenase (NADP+); Provisional
1-398
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 178617 [Multi-domain]
Cd Length: 483
Bit Score: 733.22
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MDGDEMTR I IWQ F IK E KLI L P HV D IQL KYFDLG LP NRD Q TDD Q VT ID SA L AT Q KY S VA V KCATITPDEARV E EF K LK K MW 80
Cdd:PLN03065 83 MDGDEMTR V IWQ M IK D KLI F P YL D LDI KYFDLG IL NRD A TDD K VT VE SA E AT L KY N VA I KCATITPDEARV K EF G LK S MW 162
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 K SPNGTIRNIL G GTVFREPI I CKNIPRLVPGW T KPI T IGRHA H GDQY K ATD F V ADRA G TF KMVF T P K DG SGVK E WE VY N F 160
Cdd:PLN03065 163 R SPNGTIRNIL N GTVFREPI L CKNIPRLVPGW K KPI C IGRHA F GDQY R ATD T V IKGP G KL KMVF V P E DG NAPV E LD VY D F 242
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 PAG GV GMG MYN T DESI SG FA H S CFQY A I QKKWPLY M STKNTILK A YDGRFKDIFQE IFDKHY K TD F DKNK IWYEHRLIDD 240
Cdd:PLN03065 243 KGP GV ALA MYN V DESI RA FA E S SMAM A L QKKWPLY L STKNTILK K YDGRFKDIFQE VYEEQW K QK F EEHS IWYEHRLIDD 322
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 241 MVA QVL KS S GG F VWACKNYDGDVQSD I LAQGFGSLGLMTSVL VCP DGKT I EAEAAHGTVTRH Y R E HQKG RP TSTN P IASI 320
Cdd:PLN03065 323 MVA YAV KS E GG Y VWACKNYDGDVQSD L LAQGFGSLGLMTSVL LSS DGKT L EAEAAHGTVTRH F R L HQKG QE TSTN S IASI 402
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 583966148 321 FAWTRGLEHR G KLD G N QD L IR F AQM LE KV C V ETVESG A MTKDLA GC IHG LSNVK ln E HF LNT TD F L D TIKSN L DRAL G 398
Cdd:PLN03065 403 FAWTRGLEHR A KLD K N EE L LD F VHK LE SA C I ETVESG K MTKDLA IL IHG PKVSR -- E FY LNT EE F I D AVAQT L ATKR G 478
PLN00103
PLN00103 isocitrate dehydrogenase (NADP+); Provisional
1-397
0e+00
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177720
Cd Length: 410
Bit Score: 699.28
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MDGDEMTR I IW QF IK E KLI L P HV D IQL KYFDLGLPNRD Q TDD Q VT ID SA L AT Q KY S VA V KCATITPDEARV E EF K LK K MW 80
Cdd:PLN00103 15 MDGDEMTR V IW KS IK D KLI F P FL D LDI KYFDLGLPNRD A TDD K VT VE SA E AT L KY N VA I KCATITPDEARV K EF G LK Q MW 94
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNIL G GTVFREPIICKNIPRLVPGWTKPI T IGRHA H GDQY K ATD F V ADRA G TF K M VF T P KDGSGVK E W EVYNF 160
Cdd:PLN00103 95 KSPNGTIRNIL N GTVFREPIICKNIPRLVPGWTKPI C IGRHA F GDQY R ATD A V IKGP G KL K L VF V P EGKDEKT E L EVYNF 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 P - AGGV GMG MYNTDESI SG FA HSCFQY A I QKKWPLY M STKNTILK A YDGRFKDIFQE IFDKHY K TD F DKNK IWYEHRLID 239
Cdd:PLN00103 175 T g AGGV ALS MYNTDESI RA FA EASMNT A Y QKKWPLY L STKNTILK K YDGRFKDIFQE VYEAQW K SK F EAAG IWYEHRLID 254
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 240 DMVA QV LKS S GG F VWACKNYDGDVQSD I LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR E HQKG RP TSTN P IAS 319
Cdd:PLN00103 255 DMVA YA LKS E GG Y VWACKNYDGDVQSD F LAQGFGSLGLMTSVLVCPDGKTIEAEAAHGTVTRHYR V HQKG GE TSTN S IAS 334
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 583966148 320 IFAW T RGL E HR G KLDGN QD L IR F AQM LE KV CV E TVESG A MTKDLA GC IHG l SN V K l NEHF LNT TD F L D TIKSN L DRA L 397
Cdd:PLN00103 335 IFAW S RGL A HR A KLDGN AR L LD F TEK LE AA CV G TVESG K MTKDLA LL IHG - PK V S - RDQY LNT EE F I D AVAEE L KAR L 410
nadp_idh_euk
TIGR00127 isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, ...
1-397
0e+00
isocitrate dehydrogenase, NADP-dependent, eukaryotic type; This model describes a eukaryotic, NADP-dependent form of isocitrate dehydrogenase. These eukaryotic enzymes differ considerably from a fairly tight cluster that includes all other related isocitrate dehydrogenases, 3-isopropylmalate dehydrogenases, and tartrate dehydrogenases. Several NAD- or NADP-dependent dehydrogenases, including 3-isopropylmalate dehydrogenase, tartrate dehydrogenase, and the multimeric forms of isocitrate dehydrogenase, share a nucleotide binding domain unrelated to that of lactate dehydrogenase and its homologs. These enzymes dehydrogenate their substates at a H-C-OH site adjacent to a H-C-COOH site; the latter carbon, now adjacent to a carbonyl group, readily decarboxylates. This model does not discriminate cytosolic, mitochondrial, and chloroplast proteins. However, the model starts very near the amino end of the cytosolic form; the finding of additional amino-terminal sequence may indicate a transit peptide. [Energy metabolism, TCA cycle]
Pssm-ID: 129233
Cd Length: 409
Bit Score: 686.99
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MDGDEMTRIIW QF IK E KLILP H V DIQ LKY F DLG LPN RD Q T D DQVT I D S A L A TQ KY S V A VKCATITPDEARVEEFKLKKMW 80
Cdd:TIGR00127 12 MDGDEMTRIIW EL IK D KLILP Y V ELD LKY Y DLG VEY RD A T N DQVT V D A A E A IK KY N V G VKCATITPDEARVEEFKLKKMW 91
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 81 KSPNGTIRNILGGTVFREPIICKNIPRLVPGW T KPI T IGRHA H GDQY K ATDFV ADRA G TFKM V FT PKDG SGVKEWE VY N F 160
Cdd:TIGR00127 92 KSPNGTIRNILGGTVFREPIICKNIPRLVPGW E KPI I IGRHA F GDQY R ATDFV VPGP G KLEL V YK PKDG TQKVTLK VY D F 171
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 161 P - A GGV G M G MYNTDESI S GFAHS C FQ Y A IQ KKWPLY M STKNTILK A YDGRFKDIFQE IFDKH YK TD F DKNK IWYEHRLID 239
Cdd:TIGR00127 172 E e G GGV A M A MYNTDESI E GFAHS S FQ L A LE KKWPLY L STKNTILK K YDGRFKDIFQE VYEAQ YK SK F EALG IWYEHRLID 251
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 240 DMVAQ V LKS S GGF V WACKNYDGDVQSDI L AQGFGSLGLMTSVL V CPDGKT I EAEAAHGTVTRHYR EH QKG RP TSTN P IAS 319
Cdd:TIGR00127 252 DMVAQ A LKS E GGF I WACKNYDGDVQSDI V AQGFGSLGLMTSVL I CPDGKT F EAEAAHGTVTRHYR MY QKG QE TSTN S IAS 331
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 583966148 320 IFAW T RGL E HR G KLD G N QD L IR FA QM LE KV C VE TVE S G A MTKDLA GCIH G LSNVK ln EHF LNT TD F L D TIKSN L DRAL 397
Cdd:TIGR00127 332 IFAW S RGL A HR A KLD N N PE L SK FA NI LE SA C IN TVE A G I MTKDLA LILG G SPVER -- SAY LNT EE F I D AVEER L KKKI 407
Icd
COG0538 Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part ...
1-395
0e+00
Isocitrate dehydrogenase [Energy production and conversion]; Isocitrate dehydrogenase is part of the Pathway/BioSystem: TCA cycle
Pssm-ID: 440304
Cd Length: 409
Bit Score: 525.83
E-value: 0e+00
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MD GD ---- E M TR I IW QF I KEKLILPH --- V DI QL K YF D L G LPN RD Q T D D QVTIDS A L A TQK Y S V AV K CATI TP DEA rvee 73
Cdd:COG0538 24 IE GD gigp E I TR A IW KV I DAAVEKAY ggk R DI EW K EV D A G EKA RD E T G D WLPDET A E A IKE Y G V GI K GPLT TP VGG ---- 99
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 74 fklkk M W K S P N G TIR N IL GGT V F R E P I - IC K NI P RL V PGW - TKP I T I G R HAHG D Q Y KATDFV A DRAGTF K MV F TPK D GS G 151
Cdd:COG0538 100 ----- G W R S L N V TIR Q IL DLY V C R R P V r YF K GV P SP V KHP e KVD I V I F R ENTE D I Y AGIEWK A GSPEAL K LI F FLE D EM G 174
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 152 V kew E V YN FP AG - G V G MGMYN t DE SISGFAHSCF QYA IQ - K KWPLYMST K NT I L K AYD G R FKD IFQ E IFDKHYKTD F --- 226
Cdd:COG0538 175 V --- T V IR FP ED s G I G IKPVS - DE GTERLVRAAI QYA LD n K RKSVTLVH K GN I M K FTE G A FKD WGY E VAEEEFGDK F ite 250
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 227 ---------- DKN KI W Y EH R LI DDM VA Q V L KSS G G - F V W A C KN YD GD VQ SD I LA QGF G S LG LMTSVLVCP DG K t I E A EA A 295
Cdd:COG0538 251 gpwekykgpk PAG KI V Y KD R IA DDM LQ Q I L LRP G E y D V I A T KN LN GD YI SD A LA AQV G G LG IAPGANIGD DG G - A E F EA T 329
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 296 HGT VTRH yrehqk GRPT STNP IAS I FAW T RG L E HRG K L DG nqdlirf A QML EK VCVE T V ESG AM T K DLA GCIH G lsnvkl 375
Cdd:COG0538 330 HGT APKY ------ AGKD STNP GSL I LSG T MM L R HRG W L EA ------- A DLI EK AVEK T I ESG KV T Y DLA RLME G ------ 390
410 420
....*....|....*....|
gi 583966148 376 n EHF L N T TD F L D T I KS NLD R 395
Cdd:COG0538 391 - ATE L S T SE F G D A I IE NLD K 409
Iso_dh
pfam00180 Isocitrate/isopropylmalate dehydrogenase;
1-389
7.47e-91
Isocitrate/isopropylmalate dehydrogenase;
Pssm-ID: 425507
Cd Length: 346
Bit Score: 277.64
E-value: 7.47e-91
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 1 MD G D E MTRIIWQFI K EK L ILPHVDIQLKYF D L G LPNR D Q T DDQVTIDSAL A TQ K YSVAVKC A TIT P D ---- EA R V E EF k L 76
Cdd:pfam00180 9 GI G P E VMAAALKVL K AA L EKAPLEFEFEER D V G GAAI D E T GEPLPDETLE A CK K ADAVLLG A VGG P K wdpa GV R P E NG - L 87
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 77 KKMW K SP n G TIR N ILGGT VF R e P IICKNIPRLVPGWTK p I T I G R HAH G DQ Y KATD fvadragtfkmvf TPKD GSG VK ewe 156
Cdd:pfam00180 88 LALR K EL - G LFA N LRPAK VF P - P LGDASPLKNEVEGVD - I V I V R ELT G GI Y FGIE ------------- KGIK GSG NE --- 148
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 157 vynfpa GG V GMGM Y NT DE s I SGF A HSC F QY A IQK - KWPLYMST K NTI LK AY D g RFKD I FQ E IFDKH Y K tdfdkn KIWY EH 235
Cdd:pfam00180 149 ------ VA V DTKL Y SR DE - I ERI A RVA F EL A RKR g RKKVTSVD K ANV LK SS D - LWRK I VT E VAKAE Y P ------ DVEL EH 214
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 236 R L I D DMVA Q VL K SSGG F - V WACK N YD GD VQ SD ILAQGF GSLGL MT S VLVCPD G k TIEA E AA HG TVTRHYREHQ kgrpts T 314
Cdd:pfam00180 215 Q L V D NAAM Q LV K NPSQ F d V IVTP N LF GD IL SD EASMLT GSLGL LP S ASLGAN G - FGIF E PV HG SAPDIAGKGI ------ A 287
330 340 350 360 370 380 390
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 583966148 315 NPIA S I FAWTRG L EHRGK L DGN qdlirf A QML E KVCVETV ESG AM T K DLAG cihglsnvkl NEHFLN T TD F LDTI 389
Cdd:pfam00180 288 NPIA T I LSAAMM L RYSLG L EDA ------ A DKI E AAVLKVL ESG IR T G DLAG ---------- SATYVS T SE F GEAV 346
PLN00096
PLN00096 isocitrate dehydrogenase (NADP+); Provisional
3-393
3.56e-48
isocitrate dehydrogenase (NADP+); Provisional
Pssm-ID: 177715
Cd Length: 393
Bit Score: 168.29
E-value: 3.56e-48
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 3 G D EMTR IIWQF I KE K L I L PHVD I - QLKY FDL GLP NRD Q T D DQV TI D SAL A TQKYSVAV K CA TITP DEAR V EEFK LKK M W K 81
Cdd:PLN00096 6 G E EMTR YTMDL I LA K W I E PHVD T s AWEF FDL RAK NRD D T E DQV LR D VIE A GARLKAIF K EP TITP TADQ V KRLG LKK A W G 85
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 82 SPNG TI R NILG G - T VF R EP I ick N I PRLVP G WT KP ITIG RHA H G DQ Y K A TDFVADR a GT FKMV F T P KD G SG --- V KEWEV 157
Cdd:PLN00096 86 SPNG AM R RGWN G i T IS R DT I --- H I DGVEL G YK KP VFFE RHA V G GE Y S A GYKIVGK - GT LVTT F V P EE G GK piv V DDRTI 161
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 158 YNFPAGG V gm GMY N TDESISGF A HSC F QYAIQKKWPL Y MS TK N T IL K a YDGR F KD I FQEI FD KHY K TD F DKNKIWYE --- 234
Cdd:PLN00096 162 TDDLNAV V -- TYH N PLDNVHHL A RIF F GRCLDAGIVP Y VV TK K T VF K - WQEP F WE I MKKV FD EEF K SK F VDKGVMKS gde 238
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 235 -- H R L I D DMVAQ - V LKSS GGF VW A CK NYDGDV QS D I LAQ GFG S L G LM TS V LV CP D -- G KT I - E A EA A HGTVT RHYREHQK 308
Cdd:PLN00096 239 lv H L L S D AATMK l V VWTD GGF GM A AH NYDGDV LT D E LAQ VHK S P G FI TS N LV GV D en G TL I k E F EA S HGTVT DMDEARLR 318
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 309 G RP TS T NP IASIFAWTRGLE H RGKLD G NQDLIR - F AQM L EK V CVETVES G AM T K DL A G C i H GL S nvklnehfln T TD F L D 387
Cdd:PLN00096 319 G EE TS L NP LGMVEGLIGAMN H AADVH G GKERVH p F TAK L RA V IHKLFRE G RG T R DL C G A - G GL T ---------- T EQ F I D 387
....*.
gi 583966148 388 TIKSN L 393
Cdd:PLN00096 388 AVAEE L 393
PLN00118
PLN00118 isocitrate dehydrogenase (NAD+)
199-298
1.54e-04
isocitrate dehydrogenase (NAD+)
Pssm-ID: 215062
Cd Length: 372
Bit Score: 43.33
E-value: 1.54e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 583966148 199 K NT I L K AY DG R F KDIFQ E IFD K H yktdfdk NK I W YE HRL ID DMVAQVL K SSGG F - V WACK N YD GD VQ SD IL A QGF G S LGL 277
Cdd:PLN00118 210 K AN I M K KT DG L F LKCCR E VAE K Y ------- PE I V YE EVI ID NCCMMLV K NPAL F d V LVMP N LY GD II SD LC A GLI G G LGL 282
90 100
....*....|....*....|.
gi 583966148 278 MT S VLVCPD G KTI e AEA A HG T 298
Cdd:PLN00118 283 TP S CNIGEN G LAL - AEA V HG S 302
Blast search parameters
Data Source:
Precalculated data, version = cdd.v.3.21
Preset Options: Database: CDSEARCH/cdd Low complexity filter: no Composition Based Adjustment: yes E-value threshold: 0.01
