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Conserved domains on  [gi|573459784|ref|NP_001275959|]
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N-acetylgalactosamine kinase isoform 3 [Homo sapiens]

Protein Classification

galactokinase family protein( domain architecture ID 1004942)

galactokinase family protein such as galactokinase that catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P)

CATH:  1.20.1440.340|3.30.230.10|3.30.70.3170
EC:  2.7.1.-
Gene Ontology:  GO:0005524|GO:0004335|GO:0005975
PubMed:  26862196|15526155

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
PLN02521 super family cl33510
galactokinase
 2-431 1.70e-159

galactokinase


The actual alignment was detected with superfamily member PLN02521:

Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 1.70e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521 119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521 199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521 279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521 356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 573459784 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 431
Cdd:PLN02521 436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-431 1.70e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 1.70e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521 119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521 199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521 279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521 356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 573459784 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 431
Cdd:PLN02521 436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-431 1.73e-86

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 268.56  E-value: 1.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153    9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYI 158
Cdd:COG0153   87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 237
Cdd:COG0153  163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 238 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 317
Cdd:COG0153  237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 318 VLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 396
Cdd:COG0153  273 VLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 573459784 397 LANVHKAYYQRsdGSLAPEkqsLFATKPGGGALVL 431
Cdd:COG0153  350 IEAVAEAYAEK--TGLEPD---FYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-429 2.53e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 247.82  E-value: 2.53e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784    2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSER 156
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  157 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 235
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  236 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 315
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  316 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 394
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 573459784  395 SFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 429
Cdd:TIGR00131 355 KVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 1.15e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.15e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 573459784    2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
 
Name Accession Description Interval E-value
PLN02521 PLN02521
galactokinase
 2-431 1.70e-159

galactokinase


Pssm-ID: 215285 [Multi-domain]  Cd Length: 497  Bit Score: 459.56  E-value: 1.70e-159
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTY-ALQLANTNPLYPDFSTSANNIQ-IDKT 79
Cdd:PLN02521  39 FVEVYGAKPDLFARSPGRVNLIGEHIDYEGYSVLPMAIRQDTIVAIRRAEGSkKLRIANVNDKYTTCTFPADPDQeVDLA 118

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  80 KPLWHNYFLCGLKGIQEHFGLSN-----LTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKS 154
Cdd:PLN02521 119 NHKWGNYFICGYKGVFEFLKSKGvdvgpPVGLDVVVDGTVPTGSGLSSSAALVCSAAIAIMAALGLNFTKKEVAQFTCKC 198

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 155 ERYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNKAATSH--FNIRVMECRLAAKLLA- 231
Cdd:PLN02521 199 ERHIGTQSGGMDQAISIMAQQGVAKLIDFNPVRATDVQLPAGGTFVIANSLAESNKAVTAAtnYNNRVVECRLAAIVLAv 278

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 232 KYKSLQWD---KVLRLEEVQaKLGISLEE------MLLVTEDALHPEPYNPEEICRCLGISLEELRTQilSPNTQDVLI- 301
Cdd:PLN02521 279 KLGMSAEEaisKVKTLSDVE-GLCVSFAGshgssdPAVAVKELLHEGPYTAEEIEEILGESLTSIFKN--SPTSLAVLKa 355

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 302 ---FKLYQRAKHVYSEAARVLQFKKICEE--APENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLT 376
Cdd:PLN02521 356 akhFKLHQRAVHVYSEAKRVHAFRDTVSSslSEEEKLKKLGDLMNESHYSCSVLYECSCPELEELVKVCRDNGALGARLT 435

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 573459784 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQ-RSD-GSLAPEKQSL--FATKPGGGALVL 431
Cdd:PLN02521 436 GAGWGGCAVALVKEAIVPQFILALKEKFYKsRIEkGVIKEEDLGLyvFASKPSSGAAIL 494
GalK COG0153
Galactokinase [Carbohydrate transport and metabolism];
2-431 1.73e-86

Galactokinase [Carbohydrate transport and metabolism];


Pssm-ID: 439923 [Multi-domain]  Cd Length: 380  Bit Score: 268.56  E-value: 1.73e-86
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD-FSTSANNIQIDKTK 80
Cdd:COG0153    9 FEEAFGEEPEGVFSAPGRVNLIGEHTDYNGGFVLPAAIDRGTYAAARPRDDRKVRVYSAD--FDEeVEFDLDDLEPGEED 86

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  81 PlWHNYFLcG-LKGIQEHfGLsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE-RYI 158
Cdd:COG0153   87 G-WANYVR-GvAWALQER-GY-KLGGFDLVIDGDVPLGAGLSSSAALEVAVALALNDLFGLGLDPVELAKIGQRAEnEFV 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 159 GTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKykslq 237
Cdd:COG0153  163 GVPCGIMDQFASALGKKGHALLLDCRSLEYEYVPLPlEGYALVIVDTNVKHS-LADSEYNERRAECEAAAAILGV----- 236

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 238 wdKVLRleEVqaklgiSLEEmllvtedalhpepynpeeicrclgisLEELRTQILSPntqdvlifKLYQRAKHVYSEAAR 317
Cdd:COG0153  237 --KSLR--DV------TLED--------------------------LEAARARLGDE--------VLRRRARHVVTENQR 272

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 318 VLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPADKLPSF 396
Cdd:COG0153  273 VLEAVEALR---AGDLEAFGKLMNASHASLRDDYEVSCPELDTLVELALAEaGVLGARMTGGGFGGCTIALVPKDAVDEF 349

                        410       420       430
                 ....*....|....*....|....*....|....*
gi 573459784 397 LANVHKAYYQRsdGSLAPEkqsLFATKPGGGALVL 431
Cdd:COG0153  350 IEAVAEAYAEK--TGLEPD---FYVVKPSDGARRL 379
gal_kin TIGR00131
galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, ...
 2-429 2.53e-78

galactokinase; Galactokinase is a member of the GHMP kinases (Galactokinase, Homoserine kinase, Mevalonate kinase, Phosphomevalonate kinase) and shares with them an amino-terminal domain probably related to ATP binding.The galactokinases found by this model are divided into two sets. Prokaryotic forms are generally shorter. The eukaryotic forms are longer because of additional central regions and in some cases are known to be bifunctional, with regulatory activities that are independent of galactokinase activity. [Energy metabolism, Sugars]


Pssm-ID: 272924 [Multi-domain]  Cd Length: 386  Bit Score: 247.82  E-value: 2.53e-78
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784    2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPV--KTYALQLANTNPLYPDFSTsanNIQIDKT 79
Cdd:TIGR00131   8 FASAFGAKPDFTARAPGRVNLIGEHTDYNDGSVLPCAIDFGTLCAVAVRddKNVRIYLANADNKFAERSL---DLPLDGS 84

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   80 KPL-WHNYFLCGLKGIQEHFGLSNLtGMNCLVDGNIPPSSGLSSSSALVCCAGlVTLTVLGRN--LSKVELAEICAKSER 156
Cdd:TIGR00131  85 EVSdWANYFKGVLHVAQERFNSFPL-GADIVCSGNVPTGSGLSSSAAFECAVG-AVLQNMGHLplDSKQILLRIQVAENH 162

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  157 YIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLP-SGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyks 235
Cdd:TIGR00131 163 FVGVNCGIMDQAASVLGKEDHALLVECRSLKATPFKFPqLGIAFVIANTNVKRT-LAPSNYNTRRQECTTAANFLAA--- 238

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  236 lqwdkvlrleevqaKLGISLEEMLlvtedalhPEPYNPeeicrclgislEELRTQILSPNTQdvlifklyQRAKHVYSEA 315
Cdd:TIGR00131 239 --------------TDKGALRDFM--------NEYFAR-----------YIARLTKMLPLVE--------ERAKHVVSEN 277

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  316 ARVLQFKKICEEapENMVQlLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGSRLTGAGWGGCTVSMVPADKLP 394
Cdd:TIGR00131 278 LRVLKAVKAMKD--NDFKQ-FGALMNESHASCDDDYECTCPEIDELVCSAAlVNGSGGSRMTGAGFGGCTVHLVPNENVD 354

                         410       420       430
                  ....*....|....*....|....*....|....*
gi 573459784  395 SFLANVHKAYYQRSDgslAPEKQSLFATKPGGGAL 429
Cdd:TIGR00131 355 KVRQAVADKYPKKTG---LELTFYVIVSKPGAGSC 386
PRK05322 PRK05322
galactokinase; Provisional
 2-404 6.01e-50

galactokinase; Provisional


Pssm-ID: 235407 [Multi-domain]  Cd Length: 387  Bit Score: 173.89  E-value: 6.01e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   2 FNSKFGSIPK--FYvrAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLANTNplYPD---FSTSANNIQI 76
Cdd:PRK05322  10 FAEVFGEEAEdvFF--SPGRINLIGEHTDYNGGHVFPAAITLGTYGAARKRDDKKVRLYSAN--FEDlgiIEFDLDDLSF 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  77 DKtKPLWHNYFLCGLKGIQEHfGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE- 155
Cdd:PRK05322  86 DK-EDDWANYPKGVLKFLQEA-GYKIDHGFDILIYGNIPNGAGLSSSASIELLTGVILKDLFNLDLDRLELVKLGQKTEn 163

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 156 RYIGTEGGGMDQSISFLAEEGTAKLI-------EFSPLRATDVKLpsgavfVIANScvemNKA---ATSHFNIRVMECRL 225
Cdd:PRK05322 164 EFIGVNSGIMDQFAIGMGKKDHAILLdcntleyEYVPLDLGDYVI------VIMNT----NKRrelADSKYNERRAECEK 233

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 226 AakllakykslqwdkvlrLEEVQAKLGI-SLEEmllVTEDAlhpepynpeeicrclgisLEELRTQILSPNtqdvlifkL 304
Cdd:PRK05322 234 A-----------------LEELQKKLDIkSLGE---LTEEE------------------FDEYSYLIKDET--------L 267

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 305 YQRAKHVYSEAARVLQFKKICEeapENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGC 383
Cdd:PRK05322 268 LKRARHAVTENQRTLKAVKALK---AGDLEKFGRLMNASHVSLRDDYEVTGLELDTLVEAAWKQeGVLGARMTGAGFGGC 344

                        410       420
                 ....*....|....*....|.
gi 573459784 384 TVSMVPADKLPSFLANVHKAY 404
Cdd:PRK05322 345 AIAIVKKDKVEAFKENVGKAY 365
PRK05101 PRK05101
galactokinase; Provisional
 1-408 8.81e-50

galactokinase; Provisional


Pssm-ID: 179937 [Multi-domain]  Cd Length: 382  Bit Score: 173.19  E-value: 8.81e-50
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   1 MFNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP-----VKTYALQLANtnpLYPDFSTSAnNIQ 75
Cdd:PRK05101  10 LFAQQFGYPPTHTIQAPGRVNLIGEHTDYNDGFVLPCAIDYQTVISCAKrddriVRVIAADYDN---QQDEFSLDA-PIV 85

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  76 IDKTKpLWHNYFLCGLKGIQEHfgLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSE 155
Cdd:PRK05101  86 PHPEQ-QWANYVRGVVKHLQER--NPDFGGADLVISGNVPQGAGLSSSASLEVAVGQTFQQLYHLPLSGAEIALNGQEAE 162

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 156 -RYIGTEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEMNkAATSHFNIRVMECRLAAKLLAKyk 234
Cdd:PRK05101 163 nQFVGCNCGIMDQLISALGKKDHALLIDCRSLETKAVPMPEGVAVVIINSNVKRG-LVDSEYNTRRQQCETAARFFGV-- 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 235 slqwdKVLR---LEEVQAKlgisleemllvtEDALHPEpynpeeicrclgisleelrtqilspntqdvlifkLYQRAKHV 311
Cdd:PRK05101 240 -----KALRdvtLEQFNAV------------AAELDPV----------------------------------VAKRARHV 268

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 312 YSEAARVLQFKKICEEapENMVqLLGELMNQSHMSCRDMYECSCPELDQLVDICR-KFGAQGS-RLTGAGWGGCTVSMVP 389
Cdd:PRK05101 269 ITENARTLEAASALAA--GDLK-RMGELMAESHASMRDDFEITVPQIDTLVEIVKaVIGDQGGvRMTGGGFGGCIVALVP 345

                        410
                 ....*....|....*....
gi 573459784 390 ADKLPSFLANVHKAYYQRS 408
Cdd:PRK05101 346 EELVEAVRQAVAEQYEAKT 364
PRK03817 PRK03817
galactokinase; Provisional
 14-407 1.74e-42

galactokinase; Provisional


Pssm-ID: 235163 [Multi-domain]  Cd Length: 351  Bit Score: 152.84  E-value: 1.74e-42
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  14 VRAPGRVNIIGEHIDYC-GYsVLPMAVEQDVLIAVEPVKTYAlqlantnpLYPDFSTSANNIQIDKTKPL--WHNYFLCG 90
Cdd:PRK03817   3 VKSPGRVNLIGEHTDYNdGY-VLPFAINLYTFLEIEKSEKFI--------FYSENFNEEKTFELDKLEKLnsWADYIKGV 73

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  91 LKGIQEHFGlsNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 169
Cdd:PRK03817  74 IWVLEKRGY--EVGGVKGKVSSNLPIGAGLSSSASLEVAVAYALNEAYNLNLSKLELALLAREAENeFVGVPCGIMDQFA 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 170 SFLAEEGTAKLIEFSPLRATDVKLPSGAVFVIANSCVEmNKAATSHFNIRVMECRLAAKLLAKYKSLQwdkvlrleevqa 249
Cdd:PRK03817 152 VAFGKKDHAIFLDTMTLEYEYVPFPEDYEILVFDTGVK-RELASSEYNERRQECEEALKILGKKSSKE------------ 218

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 250 klgisleemllVTEDALHpepynpeeicrclgiSLEELrtqilspntqdvlifkLYQRAKHVYSEAARVLQFKKICEeap 329
Cdd:PRK03817 219 -----------VTEEDLS---------------KLPPL----------------LRKRAGYVLRENERVLKVRDALK--- 253

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 573459784 330 ENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 407
Cdd:PRK03817 254 EGDIETLGELLTESHWDLADNYEVSCEELDFFVEFALELGAYGARLTGAGFGGSAIALVDKGKFESIGEELLEEYKKR 331
PRK00555 PRK00555
galactokinase; Provisional
 16-428 1.66e-27

galactokinase; Provisional


Pssm-ID: 179063 [Multi-domain]  Cd Length: 363  Bit Score: 112.26  E-value: 1.66e-27
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  16 APGRVNIIGEHIDY-CGYSvLPMAVEQDVLIAVEPVKTYALQLANtnplypDFSTSANNIQIDkTKPL----WHNYFLCG 90
Cdd:PRK00555   7 APGRINLIGEHTDYnLGFA-LPIALPQRTVVTFTPEHTDAITASS------DRADGSARIPLD-TTPGqvtgWAAYAAGV 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  91 LKGIQEHFglSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSER-YIGTEGGGMDQSI 169
Cdd:PRK00555  79 IWALRGAG--HPVPGGAMSITSDVEIGSGLSSSAALECAVLGAVGAATGTRIDRLEQARLAQRAENeYVGAPTGLLDQLA 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 170 SFLAEEGTAKLIEFSPLRATDVKLPSGA--VFVIANSCVEMNKAATSHFNIRVMECRLAAKLLAkykslqwdkVLRLEEV 247
Cdd:PRK00555 157 ALFGAPKTALLIDFRDLTVRPVAFDPDAagVVLLLMDSRARHRHAGGEYAARRASCERAAADLG---------VSSLRAV 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 248 QAKLGISLeemllvtedalhpepynpeeicrclgisleelrTQILSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEE 327
Cdd:PRK00555 228 QDRGLAAL---------------------------------GAIADPID--------ARRARHVLTENQRVLDFAAALAD 266

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 328 APenmVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYyqR 407
Cdd:PRK00555 267 SD---FTAAGQLLTASHASMRDDFEITTERIDLIADSAVRAGALGARMTGGGFGGCVIALVPADRAEDVADTVRRAA--V 341

                        410       420
                 ....*....|....*....|.
gi 573459784 408 SDGSLAPekqSLFATKPGGGA 428
Cdd:PRK00555 342 TAGYPEP---AVSRTYAAPGA 359
GalKase_gal_bdg pfam10509
Galactokinase galactose-binding signature; This is the highly conserved galactokinase ...
 2-49 1.15e-21

Galactokinase galactose-binding signature; This is the highly conserved galactokinase signature sequence which appears to be present in all galactokinases irrespective of how many other ATP binding sites, etc that they carry. The function of this domain appears to be to bind galactose, and the domain is normally at the N-terminus of the enzymes, EC:2.7.1.6. This domain is associated with the families GHMP_kinases_C, pfam08544 and GHMP_kinases_N, pfam00288.


Pssm-ID: 463125 [Multi-domain]  Cd Length: 50  Bit Score: 87.51  E-value: 1.15e-21
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|....*...
gi 573459784    2 FNSKFGSIPKFYVRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEP 49
Cdd:pfam10509   3 FEELFGKEPVGVASAPGRVNLIGEHTDYNGGFVLPAAINLDTYVAVSP 50
PTZ00290 PTZ00290
galactokinase; Provisional
 16-407 5.91e-17

galactokinase; Provisional


Pssm-ID: 240347 [Multi-domain]  Cd Length: 468  Bit Score: 82.56  E-value: 5.91e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  16 APGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYA---LQLANTNPLYpdfstsannIQIDKTKPLWHN----YFL 88
Cdd:PTZ00290  42 APGRVNFIGEHVDYMGGYVCPAAVLEGCHILVGRVKHFCdhkLRFATETDEH---------FVLDHLGGAKHNkawtTFV 112

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  89 CGLKGIQ-EHFGLS----NLTGMNCLVDGNIPPSSGLSSSSAL-VCCAGLVTLTVLGR----------------NLSKVE 146
Cdd:PTZ00290 113 RGAATLRlNRLGVAidapSLQGVCMVVHGTLPMGAGMSASASFgVALLNAINTVVTRRykgcptspgrrysilpPMSKEE 192

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 147 LAEIcAKSERYIGTEGGG-----MDQSISFLAEEG----------TAKLIEFSPLratdvkLPSGAVFVIANSCVEMNka 211
Cdd:PTZ00290 193 LIEL-AKQARRIETEFCGvnvgiMDQFISAFAEEDkfmfldckslTFESHDMTPL------LGDGACFLLIDSMIKHD-- 263

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 212 atshfnirvmecrLAAKLLAKYKSLQWDkvlrLEEVQAKLG--ISLEEMLLVTEDALHPEPY----NPEEIcrclgisLE 285
Cdd:PTZ00290 264 -------------LLGGTAGMYNTVRSD----QEGAQKKIGkhRYRGKPFTFSDLVRNPKKYtfdgDVVAF-------ME 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 286 ELRTQiLSPNTqdvlifklYQRAKHVYSEAARVLQFKKICEEA----PENMVQLLGELMNQSHMSCRDMYECSCPELDQL 361
Cdd:PTZ00290 320 SCKPL-MTPGE--------FERGTYNIMEQIRTLEFIKLNDPElplsREERFRKAGEILNAGHQGMRDLMKITTPELDFI 390

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|....*..
gi 573459784 362 VD-ICRKFGAQGSRLTGAGWGGCTVSMVPADKLPSFLANVHKAYYQR 407
Cdd:PTZ00290 391 HElINEEKGVAGGRMMGGGFGGCIILLLKKNAVDRVVAHVREKFKAR 437
PLN02865 PLN02865
galactokinase
 14-431 1.07e-14

galactokinase


Pssm-ID: 215466 [Multi-domain]  Cd Length: 423  Bit Score: 75.61  E-value: 1.07e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  14 VRAPGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLAnTNPLYPDFSTSANNIQ------IDKTKP--LWHN 85
Cdd:PLN02865  33 VVSPYRICPLGAHIDHQGGTVSAMTINKGILLGFVPSGDPEVLLR-SAQFEGEVRFRVDEIQhpianvSSDSKEesNWGD 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  86 YFLCGLKGIQEhFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVT------LTVlgRNLSKVELAEICakSERYIG 159
Cdd:PLN02865 112 YARGAVYALQS-RGHALSQGITGYISGSEGLDSSGLSSSAAVGVAYLLAlenannLTV--SPEDNIELDRLI--ENEYLG 186

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 160 TEGGGMDQSISFLAEEGTAKLIEFSPLRATDVKLPSGAV-------FVIANSCVEMNKAATSHFNIRVMECRLAAKLLAK 232
Cdd:PLN02865 187 LRNGILDQSAILLSRYGCLTFMDCKTLDHKLVSLQFQQPggekpfkILLAFSGLRHALTNKPGYNLRVSECQEAARFLLE 266

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 233 YKSLqwdkvlrlEEVQAKLGisleemllvtedALHPEPYnpeeicrclgisleELRTQILSPNtqdvlifkLYQRAKHVY 312
Cdd:PLN02865 267 ASGN--------DELEPLLC------------NVEPEVY--------------EAHKCKLEAV--------LARRAEHYF 304

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 313 SEAARVLqfkKICEEAPENMVQLLGELMNQSHMSCRDMYECSCPELDQLVDICRKF-GAQGSRLTGAGWGGCTVSMVPAD 391
Cdd:PLN02865 305 SENMRVI---KGVEAWASGNLEEFGKLISASGLSSIENYECGCEPLIQLYEILLKApGVYGARFSGAGFRGCCVAFVDAE 381

                        410       420       430       440
                 ....*....|....*....|....*....|....*....|...
gi 573459784 392 KLPSFLANVhKAYYQRSDGSLA---PEKQSLFATKPGGGALVL 431
Cdd:PLN02865 382 MAEEAASFV-RDEYEKAQPELAsniNGDKPVLICEAGDCARVL 423
ERG12 COG1577
Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway ...
 16-383 9.74e-14

Mevalonate kinase [Lipid transport and metabolism]; Mevalonate kinase is part of the Pathway/BioSystem: Isoprenoid biosynthesis


Pssm-ID: 441185 [Multi-domain]  Cd Length: 277  Bit Score: 71.03  E-value: 9.74e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  16 APGRVNIIGEHIDYCGYSVLPMAVEQDVLIAVEPVKTYALQLantnplYPDFSTSANNIQIDKTKPLwhNYFLCGLKGIQ 95
Cdd:COG1577    1 APGKLILFGEHAVVYGQPAIAVAVDRRATVTVEPSDDDKLRI------ESPDLGGTLDLDPLADAAL--RYIKAAIEAAL 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  96 EHFGLSNlTGMNCLVDGNIPPSsglssssalvccAGL-----VT-------LTVLGRNLSKVELAEICAKSERYIGTEGG 163
Cdd:COG1577   73 EYLGLPL-KGFDIEIDSEIPRK------------RGLgssaaVAvaviralAAFYGVELSKEELFKLALEAEKIVHGNPS 139

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 164 GMDQSISFLaeEGtakLIEF-SPLRATDVKLPSGAVFVIANSCVemnKAATSHfnirvmecrLAAKLLAKYKSlqwdkvl 242
Cdd:COG1577  140 GLDTAASTY--GG---PIYYqRGDRAEPLELPKNLPLVVGDTGV---PASTKE---------LVAKVRKLKER------- 195

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 243 rleevqaklgisleemllvtedalHPEPYNPeeicrclgisleelrtqilspntqdvlifkLYQRAKHVYSEAARVLQfk 322
Cdd:COG1577  196 ------------------------NPELYEA------------------------------FLEEIGDLVEEAIEALE-- 219

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 573459784 323 kiceeapENMVQLLGELMNQSHmscRDMYE--CSCPELDQLVDICRKFGAQGSRLTGAGWGGC 383
Cdd:COG1577  220 -------EGDLEALGELMNENH---GLLRAlgVSTPELDRLVEAARKAGALGAKLTGAGGGGC 272
PTZ00298 PTZ00298
mevalonate kinase; Provisional
 303-387 2.66e-11

mevalonate kinase; Provisional


Pssm-ID: 240351 [Multi-domain]  Cd Length: 328  Bit Score: 64.49  E-value: 2.66e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 303 KLYQRAKHVYSEAARVLQfkkiceeapENMVQLLGELMNQSHMSCRDMyECSCPELDQLVDICRKFGAQGSRLTGAGWGG 382
Cdd:PTZ00298 218 RLLENYNACVSEAKEALQ---------KGNLFRVGELMNANHDLCQKL-TVSCRELDSIVQTCRTYGALGAKMSGTGRGG 287


                 ....*
gi 573459784 383 CTVSM 387
Cdd:PTZ00298 288 LVVAL 292
mevalon_kin TIGR00549
mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate ...
 16-385 1.42e-10

mevalonate kinase; This model represents mevalonate kinase, the third step in the mevalonate pathway of isopentanyl pyrophosphate (IPP) biosynthesis. IPP is a common intermediate for a number of pathways including cholesterol biosynthesis. This model covers enzymes from eukaryotes, archaea and bacteria. The related enzyme from the same pathway, phosphmevalonate kinase, serves as an outgroup for this clade. Paracoccus exhibits two genes within the phosphomevalonate/mevalonate kinase family, one of which falls between trusted and noise cutoffs of this model. The degree of divergence is high, but if the trees created from this model are correct, the proper names of these genes have been swapped. [Central intermediary metabolism, Other]


Pssm-ID: 273130 [Multi-domain]  Cd Length: 273  Bit Score: 61.54  E-value: 1.42e-10
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   16 APGRVNIIGEHIDYCGYSVLPMAVEQ-DVLIAVEPVKTYALQLANTNPLYPDFSTSANNIqidktkplwHNYFLCGLKgi 94
Cdd:TIGR00549   1 APGKIILFGEHAVVYGEPAIAAPIPLrTTVTVIESSDGSFIESDLGRGSLDDAPDELDGL---------KYVLAEFLS-- 69

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784   95 qeHFGLSNLTGMNCLVDGNIPPSSGLSSSSALVCCAGLVTLTVLGRNLSKVELAEICAKSERYIGTEGGGMDQSISflae 174
Cdd:TIGR00549  70 --RFSELNPPPLEITIESEIPPGRGLGSSAAVAVALIRALADYFGSELSKEELAELANEAEKIAHGKPSGIDTATS---- 143

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  175 eGTAKLIEFSPLRATDVKLPS-GAVFVIANSCVEmnkaatshfnirvmecRLAAKLLAKYKSLqwdkvlrLEEvqaklgi 253
Cdd:TIGR00549 144 -TSGGPVYFEKGEGEFTKLISlDGYFVIADTGVS----------------GSTKEAVARVRQL-------LER------- 192

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  254 sleemllvtedalHPEpynpeeicrclgisleelrtqilspntqdvLIFKLYQRAKHVYSEAARVLQFKKiceeapenmV 333
Cdd:TIGR00549 193 -------------FPE------------------------------LIDSIMDAIGELTLEAKAALQDGD---------V 220

                         330       340       350       360       370
                  ....*....|....*....|....*....|....*....|....*....|..
gi 573459784  334 QLLGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTV 385
Cdd:TIGR00549 221 ESLGELMNINQ-GLLKALGVSHPKLDQLVEIARKAGALGAKLTGAGGGGCMI 271
PRK03926 PRK03926
mevalonate kinase; Provisional
 336-392 1.74e-08

mevalonate kinase; Provisional


Pssm-ID: 179677 [Multi-domain]  Cd Length: 302  Bit Score: 55.44  E-value: 1.74e-08
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*..
gi 573459784 336 LGELMNQSHmSCRDMYECSCPELDQLVDICRKFGAQGSRLTGAGWGGCTVSMVPADK 392
Cdd:PRK03926 216 LGELMNINQ-GLLDALGVSTKELSELIYAARTAGALGAKITGAGGGGCMVALAAPEK 271
GHMP_kinases_C pfam08544
GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and ...
 326-406 2.09e-08

GHMP kinases C terminal; This family includes homoserine kinases, galactokinases and mevalonate kinases.


Pssm-ID: 430063 [Multi-domain]  Cd Length: 85  Bit Score: 51.32  E-value: 2.09e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784  326 EEAPENMVQLLGELMNQSHMSC--RDMYECSCPELDQLVDICRKFGAqGSRLTGAGWGGCTVSMVP-ADKLPSFLANVHK 402
Cdd:pfam08544   3 EALLRGDLEELGKLLTESAESLepLLVVGILPPELDELLEALLELGL-GAKLSGSGGGPTVFALFKdEDDAEEVARALRE 81


                  ....
gi 573459784  403 AYYQ 406
Cdd:pfam08544  82 AGKK 85
COG2605 COG2605
Predicted kinase related to galactokinase and mevalonate kinase [General function prediction ...
 306-415 1.01e-05

Predicted kinase related to galactokinase and mevalonate kinase [General function prediction only];


Pssm-ID: 442017 [Multi-domain]  Cd Length: 328  Bit Score: 47.10  E-value: 1.01e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 573459784 306 QRAKHVYSEAARVLQFKKICEEApENMVQLL--------GELMNQSHMSCRDMYE-CSCPELDQLVDICRKFGAQGSRLT 376
Cdd:COG2605  205 QVKNVEDGDEATLEALHEMKELA-LEMKEALlkgdldefGELLNEGWELKKRLASgISNPAIDEIYELARKAGALGGKLL 283

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 573459784 377 GAGWGGCTVSMVPADKLPSFLANVHKAYYQRSDGSLAPE 415
Cdd:COG2605  284 GAGGGGFLLFYAPPERREAVREALSKAGLRVVPFSFDKE 322
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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