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Conserved domains on  [gi|564730477|ref|NP_001274185|]
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zinc finger protein 596 isoform 1 [Homo sapiens]

Protein Classification

KRAB domain-containing zinc finger protein( domain architecture ID 12204794)

KRAB (Kruppel-associated box) domain-containing zinc finger protein (KRAB-ZFP) plays important roles in cell differentiation and organ development and in regulating viral replication and transcription

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
7-67 2.87e-24

krueppel associated box;


:

Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 2.87e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564730477     7 MTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLST 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-502 1.62e-09

FOG: Zn-finger [General function prediction only];


:

Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 361 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 432
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564730477 433 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 502
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
SFP1 super family cl25788
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-329 9.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


The actual alignment was detected with superfamily member COG5189:

Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 247 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 324
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 564730477 325 HeRTH 329
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.00e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  321 YLRQHERTHNGEKPYECHLCGKAFSH 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-234 5.83e-03

Zinc-finger double domain;


:

Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  209 NLRRHEMIHTGEKPHGCHLCGKAFTH 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
7-67 2.87e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 2.87e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564730477     7 MTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLST 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-47 9.78e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.13  E-value: 9.78e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564730477    6 SMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIG 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 8.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 8.23e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564730477   7 MTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSI 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-502 1.62e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 361 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 432
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564730477 433 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 502
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 9.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 9.82e-05
                          10        20
                  ....*....|....*....|....*.
gi 564730477  405 DLRRHERTHTGEKPYECHLCGKAFNH 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-329 9.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 247 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 324
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 564730477 325 HeRTH 329
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  321 YLRQHERTHNGEKPYECHLCGKAFSH 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-234 5.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  209 NLRRHEMIHTGEKPHGCHLCGKAFTH 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 9.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  237 DLRKHERTHTGEKPYGCHLCGKAFSK 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Name Accession Description Interval E-value
KRAB smart00349
krueppel associated box;
7-67 2.87e-24

krueppel associated box;


Pssm-ID: 214630 [Multi-domain]  Cd Length: 61  Bit Score: 95.35  E-value: 2.87e-24
                           10        20        30        40        50        60
                   ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 564730477     7 MTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIGKQLCKSVVLSQLEQVEKLST 67
Cdd:smart00349   1 VTFEDVAVYFTQEEWEQLDPAQKNLYRDVMLENYSNLVSLGFQVPKPDLISQLEQGEEPWI 61
KRAB pfam01352
KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc ...
 6-47 9.78e-20

KRAB box; The KRAB domain (or Kruppel-associated box) is present in about a third of zinc finger proteins containing C2H2 fingers. The KRAB domain is found to be involved in protein-protein interactions. The KRAB domain is generally encoded by two exons. The regions coded by the two exons are known as KRAB-A and KRAB-B. The A box plays an important role in repression by binding to corepressors, while the B box is thought to enhance this repression brought about by the A box. KRAB-containing proteins are thought to have critical functions in cell proliferation and differentiation, apoptosis and neoplastic transformation.


Pssm-ID: 460171  Cd Length: 42  Bit Score: 82.13  E-value: 9.78e-20
                          10        20        30        40
                  ....*....|....*....|....*....|....*....|..
gi 564730477    6 SMTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSIG 47
Cdd:pfam01352   1 SVTFEDVAVDFTQEEWALLDPAQRNLYRDVMLENYRNLVSLG 42
KRAB_A-box cd07765
KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression ...
 7-46 8.23e-16

KRAB (Kruppel-associated box) domain -A box; The KRAB domain is a transcription repression module, found in a subgroup of the zinc finger proteins (ZFPs) of the C2H2 family, KRAB-ZFPs. KRAB-ZFPs comprise the largest group of transcriptional regulators in mammals, and are only found in tetrapods. These proteins have been shown to play important roles in cell differentiation and organ development, and in regulating viral replication and transcription. A KRAB domain may consist of an A-box, or of an A-box plus either a B-box, a divergent B-box (b), or a C-box. Only the A-box is included in this model. The A-box is needed for repression, the B- and C- boxes are not. KRAB-ZFPs have one or two KRAB domains at their amino-terminal end, and multiple C2H2 zinc finger motifs at their C-termini. Some KRAB-ZFPs also contain a SCAN domain which mediates homo- and hetero-oligomerization. The KRAB domain is a protein-protein interaction module which represses transcription through recruiting corepressors. A key mechanism appears to be the following: KRAB-AFPs tethered to DNA recruit, via their KRAB domain, the repressor KAP1 (KRAB-associated protein-1, also known as transcription intermediary factor 1 beta , KRAB-A interacting protein , and tripartite motif protein 28). The KAP1/ KRAB-AFP complex in turn recruits the heterochromatin protein 1 (HP1) family, and other chromatin modulating proteins, leading to transcriptional repression through heterochromatin formation.


Pssm-ID: 143639  Cd Length: 40  Bit Score: 71.04  E-value: 8.23e-16
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|
gi 564730477   7 MTFEDIIVDFTQEEWALLDTSQRKLFQDVMLENISHLVSI 46
Cdd:cd07765    1 VTFEDVAVYFSQEEWELLDPAQRDLYRDVMLENYENLVSL 40
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
361-502 1.62e-09

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 60.09  E-value: 1.62e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 361 KPHGCHLCGKAFTESSVLKRHER--IHTGE--KPYECHV--CGKAFTESSDLRRHERTHTGEKPYECHL--CGKAFNHSS 432
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPYslCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPLL 367

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 564730477 433 VLRRHERTH-----TGEKPYEC--NICGKAFNRSYNFRLHRRVHTGEKPYVC--PLCGKAFSKFFNLRQHERTHTKKAM 502
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCknPPCSKSFNRHYNLIPHKKIHTNHAP 446
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
333-499 5.59e-08

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 55.09  E-value: 5.59e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 333 KPYECHLCGKAFSHCSHLRQHERS--HNGE--KPHGC--HLCGKAFTESSVLKRHERIHTGEKPYECH--VCGKAFTESS 404
Cdd:COG5048  288 LPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKllNSSSKFSPLL 367

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 405 DLRRHERTH-----TGEKPYEC--HLCGKAFNHSSVLRRHERTHTGEKPYECN--ICGKAFNRSYNFRLHRRVHTgEKPY 475
Cdd:COG5048  368 NNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHT-NHAP 446

                        170       180
                 ....*....|....*....|....
gi 564730477 476 VCPLCgkafSKFFNLRQHERTHTK 499
Cdd:COG5048  447 LLCSI----LKSFRRDLDLSNHGK 466
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
304-459 2.95e-06

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 49.69  E-value: 2.95e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 304 DKPYGCLLCGKAFSKCSYLRQHERT--HNGE--KPYEC--HLCGKAFSHCSHLRQHERSHNGEKPHGCHL--CGKAFTES 375
Cdd:COG5048  287 SLPIKSKQCNISFSRSSPLTRHLRSvnHSGEslKPFSCpySLCGKLFSRNDALKRHILLHTSISPAKEKLlnSSSKFSPL 366

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 376 SVLKRHERIH-----TGEKPYEC--HVCGKAFTESSDLRRHERTHTGEKPYECH--LCGKAFNHSSVLRRHERTHTGEKP 446
Cdd:COG5048  367 LNNEPPQSLQqykdlKNDKKSETlsNSCIRNFKRDSNLSLHIITHLSFRPYNCKnpPCSKSFNRHYNLIPHKKIHTNHAP 446

                        170
                 ....*....|...
gi 564730477 447 YECNICGKAFNRS 459
Cdd:COG5048  447 LLCSILKSFRRDL 459
zf-H2C2_2 pfam13465
Zinc-finger double domain;
405-430 9.82e-05

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 39.28  E-value: 9.82e-05
                          10        20
                  ....*....|....*....|....*.
gi 564730477  405 DLRRHERTHTGEKPYECHLCGKAFNH 430
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
434-458 1.47e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.89  E-value: 1.47e-04
                          10        20
                  ....*....|....*....|....*
gi 564730477  434 LRRHERTHTGEKPYECNICGKAFNR 458
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFKS 26
COG5048 COG5048
FOG: Zn-finger [General function prediction only];
221-500 1.62e-04

FOG: Zn-finger [General function prediction only];


Pssm-ID: 227381 [Multi-domain]  Cd Length: 467  Bit Score: 44.30  E-value: 1.62e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 221 KPHGCHLCGKAFTHCSDLRKHERTHTGEKPYGCHL--CGKAFSKSSNLRRHEMIHT----REKAQICHLCGKAFTHCSDL 294
Cdd:COG5048   32 RPDSCPNCTDSFSRLEHLTRHIRSHTGEKPSQCSYsgCDKSFSRPLELSRHLRTHHnnpsDLNSKSLPLSNSKASSSSLS 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 295 RKHERTHLGDKPYGCLLCGKAF--------SKCSYLRQHERTHNGEK-----------PYECHLCGKAFSHCSHLRQHER 355
Cdd:COG5048  112 SSSSNSNDNNLLSSHSLPPSSRdpqlpdllSISNLRNNPLPGNNSSSvntpqsnslhpPLPANSLSKDPSSNLSLLISSN 191

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 356 SHNGEKPHGCHLCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLRRH------ERTHTGEKPYECHLCGKAFN 429
Cdd:COG5048  192 VSTSIPSSSENSPLSSSYSIPSSSSDQNLENSSSSLPLTTNSQLSPKSLLSQSPsslsssDSSSSASESPRSSLPTASSQ 271

                        250       260       270       280       290       300       310
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 564730477 430 HSSVLRRHERTHTG-EKPYECNICGKAFNRSYNFRLHRR--VHTGE--KPYVCP--LCGKAFSKFFNLRQHERTHTKK 500
Cdd:COG5048  272 SSSPNESDSSSEKGfSLPIKSKQCNISFSRSSPLTRHLRsvNHSGEslKPFSCPysLCGKLFSRNDALKRHILLHTSI 349
zf-H2C2_2 pfam13465
Zinc-finger double domain;
378-401 1.91e-04

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 38.51  E-value: 1.91e-04
                          10        20
                  ....*....|....*....|....
gi 564730477  378 LKRHERIHTGEKPYECHVCGKAFT 401
Cdd:pfam13465   2 LKRHMRTHTGEKPYKCPECGKSFK 25
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 331-414 3.04e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 43.17  E-value: 3.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 331 GEKPYECHL--CGKAFshcshlrqheRSHNGEKPHGCH-LCGKAFTESSVLKRHERIHTGEKPYECHVCGKAFTESSDLR 407
Cdd:COG5189  346 DGKPYKCPVegCNKKY----------KNQNGLKYHMLHgHQNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLK 415


                 ....*..
gi 564730477 408 RHeRTHT 414
Cdd:COG5189  416 YH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 343-442 5.26e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 42.40  E-value: 5.26e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 343 AFSHCSHLRQHERSHN----GEKPHGCHL--CGKAFTESSVLKRHERihtgekpyECHvCGKAFTESSDLRRHERTHTGE 416
Cdd:COG5189  326 KLAHGGERNIDTPSRMlkvkDGKPYKCPVegCNKKYKNQNGLKYHML--------HGH-QNQKLHENPSPEKMNIFSAKD 396

                         90       100
                 ....*....|....*....|....*.
gi 564730477 417 KPYECHLCGKAFNHSSVLRRHeRTHT 442
Cdd:COG5189  397 KPYRCEVCDKRYKNLNGLKYH-RKHS 421
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 247-329 9.10e-04

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 41.63  E-value: 9.10e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 247 GEKPYGCHL--CGKAFSKSSNLRRHeMIHTRekaqichlCGKAFTHCSDLRKHERTHLGDKPYGCLLCGKAFSKCSYLRQ 324
Cdd:COG5189  346 DGKPYKCPVegCNKKYKNQNGLKYH-MLHGH--------QNQKLHENPSPEKMNIFSAKDKPYRCEVCDKRYKNLNGLKY 416


                 ....*
gi 564730477 325 HeRTH 329
Cdd:COG5189  417 H-RKH 420
zf-H2C2_2 pfam13465
Zinc-finger double domain;
321-346 1.00e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 36.58  E-value: 1.00e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  321 YLRQHERTHNGEKPYECHLCGKAFSH 346
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
SFP1 COG5189
Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division ...
 372-498 1.44e-03

Putative transcriptional repressor regulating G2/M transition [Transcription / Cell division and chromosome partitioning];


Pssm-ID: 227516 [Multi-domain]  Cd Length: 423  Bit Score: 40.86  E-value: 1.44e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 372 FTESSVLKRHERIH--TGEKPYECHVCGKaftESSDLRRHERTHTGEKPYECHLCGKAFNHSSvlrRHERThTGEKPYEC 449
Cdd:COG5189  280 FEESSLGFDYEFIHksVGNKEIRGGISTG---EMIDVRKLPCTNSSSNGKLAHGGERNIDTPS---RMLKV-KDGKPYKC 352

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 564730477 450 NI--CGKAFNRSYNFRLHRR-------------------VHTGEKPYVCPLCGKAFSKFFNLRQHeRTHT 498
Cdd:COG5189  353 PVegCNKKYKNQNGLKYHMLhghqnqklhenpspekmniFSAKDKPYRCEVCDKRYKNLNGLKYH-RKHS 421
zf-H2C2_2 pfam13465
Zinc-finger double domain;
461-486 4.98e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.65  E-value: 4.98e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  461 NFRLHRRVHTGEKPYVCPLCGKAFSK 486
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
209-234 5.83e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 34.27  E-value: 5.83e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  209 NLRRHEMIHTGEKPHGCHLCGKAFTH 234
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
zf-H2C2_2 pfam13465
Zinc-finger double domain;
237-262 9.62e-03

Zinc-finger double domain;


Pssm-ID: 463886 [Multi-domain]  Cd Length: 26  Bit Score: 33.88  E-value: 9.62e-03
                          10        20
                  ....*....|....*....|....*.
gi 564730477  237 DLRKHERTHTGEKPYGCHLCGKAFSK 262
Cdd:pfam13465   1 NLKRHMRTHTGEKPYKCPECGKSFKS 26
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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