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Conserved domains on  [gi|558757381|ref|NP_001273928|]
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alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 isoform b [Homo sapiens]

Protein Classification

glycosyltransferase family 29 protein( domain architecture ID 690)

glycosyltransferase family 29 protein catalyzes the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds; uses a nucleotide monophosphosugar as the donor (CMP-NeuA) instead of a nucleotide diphosphosugar

CATH:  3.90.1480.20
CAZY:  GT29
EC:  2.4.99.-
Gene Ontology:  GO:0008373|GO:0006486
PubMed:  9334165

Graphical summary

 Zoom to residue level

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List of domain hits

 Name Accession Description Interval E-value
GT29 super family cl45931
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 105-273 2.73e-123

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


The actual alignment was detected with superfamily member cd23978:

Pssm-ID: 480271  Cd Length: 229  Bit Score: 354.93  E-value: 2.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170
                 ....*....|
gi 558757381 264 MVPPNYCSGP 273
Cdd:cd23978  161 MVPPNYCSKR 170
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-273 2.73e-123

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 354.93  E-value: 2.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170
                 ....*....|
gi 558757381 264 MVPPNYCSGP 273
Cdd:cd23978  161 MVPPNYCSKR 170
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-268 4.71e-22

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 93.83  E-value: 4.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  181 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 247
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180
                  ....*....|....*....|.
gi 558757381  248 TMVIAVELCDHVHVYGMVPPN 268
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFL 215
 
Name Accession Description Interval E-value
GT29_ST6GALNAC6 cd23978
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are ...
 105-273 2.73e-123

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467706  Cd Length: 229  Bit Score: 354.93  E-value: 2.73e-123
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23978    1 CHQCALITSSSHLLGTSLGPEIDQTECTIRMNDAPTTGYEKDVGNKTTLRVVAHSSVYRVLRRPQEFLNRTPETTLIFWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKMQKPQGS-LVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23978   81 PPNKMQKDGKSnLFRIIQRASMTFPNMSAFVVSPRRMRQFDDLFRGETGRDRKKSHSWLSTGWFTMVIAVELCDNVHVYG 160

                        170
                 ....*....|
gi 558757381 264 MVPPNYCSGP 273
Cdd:cd23978  161 MVPPNYCSKR 170
GT29_ST6GALNAC3_4_5_6 cd23965
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family ...
 105-279 1.13e-92

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3, 4, 5 and 6; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, bytransfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substratespecificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467693  Cd Length: 225  Bit Score: 276.82  E-value: 1.13e-92
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP-QEFVNRTPETVFIFW 183
Cdd:cd23965    1 CDTCALVSSSGQLLGSGAGKEIDSADCVIRMNDAPTRGYEKDVGRRTTIRVVSHSSLPRLLRNAiLLLAGTRAPTVVVFW 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 184 GPPSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23965   81 GPETKMNKDGAGKYNLLRSLSKKYPDVEFYSLTPEKMDYADELFEKETGKSRIKSGTWLSTGWFTMLLALDVCDEIKVYG 160

                        170
                 ....*....|....*.
gi 558757381 264 MVPPNYCSGPASSACP 279
Cdd:cd23965  161 MVPENYCREHPNSKVP 176
GT29_ST6GALNAC5 cd23976
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are ...
 91-317 6.08e-76

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 5; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilize Sia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467704  Cd Length: 244  Bit Score: 234.76  E-value: 6.08e-76
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  91 GYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQE 170
Cdd:cd23976    1 GYISIIDHKPLKMHCKSCALVTSSGHLTGSNRGNEIDETECVIRMNDAPTRGYGKDVGNKTSLRVIAHSSIQRILRNRNE 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 171 FVNRTPETVFIFWGPPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTM 249
Cdd:cd23976   81 LLNVSQGTVFIFWGPSNYMRRDgKGLVYNNLQLMNQILPKLKVYTITRHKMLQFDELFKRETGKDRKISNTWLSTGWFTM 160

                        170       180       190       200       210       220
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558757381 250 VIAVELCDHVHVYGMVPPNYCSGPASSACPTTTTSPRGRTNvsptsrmstvARATTTASSPRKGSSHR 317
Cdd:cd23976  161 IIALELCDRINVYGMVPPDFCRDPNHPSVPYHYYEPSGPDE----------CTMYISHERGRKGSHHR 218
GT29_ST6GALNAC4 cd23977
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are ...
 105-279 1.28e-58

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 4; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467705  Cd Length: 228  Bit Score: 189.69  E-value: 1.28e-58
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23977    1 CRRCAVVSSSGQMLGSGLGPEIDQQECVLRMNVAPTAGYEADVGNRSSLRVVSHTSVPLLLRNQGYFFQQSRDTKYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKM-QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23977   81 PERNMdRDGGGKTYRALLTLAKMYPHLQVYTLTEEKMAYCDGVFQNETGKNRMKSGSFLSTGWFTMILALELCEEILVYG 160

                        170
                 ....*....|....*.
gi 558757381 264 MVPPNYCSGPASSACP 279
Cdd:cd23977  161 MVSDSYCRNKNHSSVP 176
GT29_ST6GALNAC3 cd23975
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are ...
 105-270 2.05e-53

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc3, 4, 5, and 6 utilizeSia2,3Galbeta1,3GalNAc as an acceptor with different individual substrate specificities. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467703  Cd Length: 226  Bit Score: 176.28  E-value: 2.05e-53
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTPETVFIFWG 184
Cdd:cd23975    1 CDLCAVVSNSGQMVGQKVGAEIDQSSCIWRMNNAPTKGYEEDVGKRTTIRVVSHTSVPLLLKNPDYFFKETNETIYVIWG 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKMQKP-QGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23975   81 PFRNMRKDgKGIVYNMLKKAVESYPQAKIYVTTEKRMSYCDTVFKKETGKDRVQSGSYLSTGWFTLILAMDACYGIHVYG 160


                 ....*..
gi 558757381 264 MVPPNYC 270
Cdd:cd23975  161 MINDTYC 167
GT29 cd19952
glycosyltransferase family 29; Glycosyltransferase family 29 members (also called ...
 108-264 1.60e-28

glycosyltransferase family 29; Glycosyltransferase family 29 members (also called sialyltransferases) are enzymes that transfer sialic acid to oligosaccharide, each having specificity for a certain sugar substrate.


Pssm-ID: 467690  Cd Length: 193  Bit Score: 109.76  E-value: 1.60e-28
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEFVNRTP---ETVFIFWG 184
Cdd:cd19952    1 CAVVGNSGILLGSEYGKEIDSHDAVFRFNQAPTKGFEKDVGSKTTFRVLNSKWAGFYLRGPRCGCHPLPleeEVVLILSR 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 185 PPSKMQKpqgslvRVIQRAGLvfPNMEAYAVSPGR---MRQFDDLFRGETGKDrEKSHSWLSTGWFTMVIAVELCDHVHV 261
Cdd:cd19952   81 AAAADFK------RLKRRKKR--HDNAVLLLTDPApdlLSYVRKRLEKLGLKS-FFGGNAPSSGLLAVLLALQLCDSVDL 151


                 ...
gi 558757381 262 YGM 264
Cdd:cd19952  152 YGF 154
Glyco_transf_29 pfam00777
Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to ...
 102-268 4.71e-22

Glycosyltransferase family 29 (sialyltransferase); Members of this family belong to glycosyltransferase family 29.


Pssm-ID: 459935  Cd Length: 256  Bit Score: 93.83  E-value: 4.71e-22
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFRVLRRPQEFVNRTPETVF 180
Cdd:pfam00777  40 NKRCRRCAVVGNGGILRGSGCGKEIDSHDFVIRCNLAPTKGYEKDVGSKTTLRTMnPESAIDSKYGNLGFSHPRDPFVEF 119

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  181 IF---------WGPPSKMQKPQGSLVRVIQRAGLVFPNmeayaVSPGRMRQFDDLFRGETGKDREKSHSW----LSTGWF 247
Cdd:pfam00777 120 VLvpfkgrdllWLPAFLTKGNVSRSLRVLYTLKEVKIP-----VDPDKVLFLHPDFLRYVANFWLRSHGLkgrrPSTGLL 194

                         170       180
                  ....*....|....*....|.
gi 558757381  248 TMVIAVELCDHVHVYGMVPPN 268
Cdd:pfam00777 195 MLSLALHLCDEVSLYGFGPFL 215
GT29_ST6GAL1_2 cd23968
beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are ...
 72-268 2.03e-20

beta-galactoside alpha-2,6-sialyltransferase 1 and 2; ST6Gal family members are beta-galactosidealpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acidand the terminal galactose residue of a glycochain, by transfering sialic acid fromCMP-Sia. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467696  Cd Length: 266  Bit Score: 89.64  E-value: 2.03e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  72 SLRGRSRRPVNLKKWSitdgYVPILGNKTLPSRCHQ-CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 150
Cdd:cd23968   15 STLRKTTSPFKDLLSL----RYPFPESSLENTKRYNtCAVVSSSGALLGSKLGKEIDSHDAVLRFNDAPTKGFEKDVGSK 90

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 151 TTYRVVAH----SSVFRVLRRPqEFVNrtpETVFIfWGPPS-------KMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGR 219
Cdd:cd23968   91 TTLRLINSqilsKPEFNFLTDP-LYRN---VTLLV-WDPSSynvnlekWYKKPDFDFFPNYIKYRRRHPEEPFYLIDPRF 165

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 558757381 220 M-RQFDDLFRGETGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVPPN 268
Cdd:cd23968  166 LwRLWDILQEYTPEKIKPNPP---SSGFIGIVLMLHLCDWVDVYEYVPSV 212
GT29_ST3GAL3_4_5_6 cd23967
beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid ...
 104-268 4.30e-20

beta-galactoside alpha-2,3-sialyltransferase 3,4,5 and 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL3 and 4 utilize bothGalbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates. ST3GAL5 is also known as GM3 ganglioside synthase. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467695  Cd Length: 205  Bit Score: 87.35  E-value: 4.30e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFrvlRRPQEFvnrTPETVFIF- 182
Cdd:cd23967    1 SCRRCVVVGNGGVLKGKSLGSVIDKYDVVIRMNDAPVKGYEKDVGSKTTFRMFYPESAF---RDPEEY---DSDWLLVLv 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 183 --------WGPPSKMQKPQGSLVRVIQRAGLVFPnmeayaVSPGRMRQFDDLFRGETG-------KDREKSHSWLSTGWF 247
Cdd:cd23967   75 pfksmdllWLQAVIKGKKPNGKGGFWKKIATSVP------KPPKKIRILNPYILQEAAfdliglpMNGKQGKNVPTTGII 148

                        170       180
                 ....*....|....*....|....*
gi 558757381 248 TMVIAVELCDHVHV----YGMVPPN 268
Cdd:cd23967  149 AIVMALHYCDEVDIagfgYDPSDPN 173
GT29_ST8SIA cd23963
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are ...
 70-263 3.12e-18

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase; ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on their catalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467691  Cd Length: 274  Bit Score: 83.46  E-value: 3.12e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  70 YGSLRGRSRRPVNLKKWSITDGYVPIlGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGN 149
Cdd:cd23963   33 YYSYFKKKTFKITKSLYELLPKTSPF-SHKRYKT----CAVVGNSGILLGSGCGKEIDSHDFVIRCNLPPIKGFEKDVGR 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 150 KTTYRVVAHSSVFRVL------RRPQEFVNRTPETV-FIFWGPPSKMQKPQGSLVRVIQRAGLVFPNME-AYAvSPGRMR 221
Cdd:cd23963  108 KTNLTTLNPSILKRRYnslkknRDRDKFLNRLKEYNgSILWYPKFSFKSSTNLLLKAARALKKNGLNLTvVYS-NPEHFL 186

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 558757381 222 QFDDlFRGETGKDRekshsWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23963  187 AVQK-FWKRRGLEK-----RPSTGLYLVSLALTFCDEIHLYG 222
GT29_ST6GAL2 cd23986
beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside ...
 92-266 6.19e-17

beta-galactoside alpha-2,6-sialyltransferase 2; ST6Gal family members are beta-galactoside alpha-2,3-sialyltransferases that catalyze an alpha2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by a transfering sialic acid from CMP-Sia. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467714  Cd Length: 270  Bit Score: 79.88  E-value: 6.19e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  92 YVP-ILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHssvfRVLRRPQE 170
Cdd:cd23986   35 YVPkIPLSKLHLRGFRSCAVVTSAGAILNSSLGKEIDSHDAVLRFNSAPTRGYEKDVGNKTTIRIINS----QILTNPNH 110

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 171 FVNRTP---ETVFIFWGP-PSKM------QKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGETGKDREKSHS 240
Cdd:cd23986  111 HFIDSSlykDVILVAWDPaPYSAnlhkwyKKPDYNLFTPYVQYRKRNPNQPFYILHPKFIWQLWDIIQENTQEKIQPNPP 190

                        170       180
                 ....*....|....*....|....*.
gi 558757381 241 wlSTGWFTMVIAVELCDHVHVYGMVP 266
Cdd:cd23986  191 --SSGFIGILIMMSMCREVHVYEYIP 214
GT29_ST6GAL1 cd23985
beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside ...
 80-266 1.44e-16

beta-galactoside alpha-2,6-sialyltransferase 1; ST6Gal family members are beta-galactoside alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the terminal galactose residue of a glycochain, by transfering sialic acid from CMP-Sia. ST6Gal1 play important roles in the immune system. The ST6Gal family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467713  Cd Length: 266  Bit Score: 78.60  E-value: 1.44e-16
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  80 PVNLKKWsitDGYVPILGNKTLPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVaHS 159
Cdd:cd23985   23 PFNTSEW---EGYLPKKSLREEVGPLGRCAVVSSAGSLKSSGLGREIDSHDAVLRFNGAPTAGFQQDVGTKTTIRLI-NS 98

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 160 SVfrVLRRPQEFVNRT--PETVFIFWGP-------PSKMQKPQGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLFRGE 230
Cdd:cd23985   99 QL--VTTEKHKFLKDSlyNEGILIVWDPapyhsdiPEWYKNPDYNFFENYKTYRRLNPNQPFYILHPQMQWELWDIIQEN 176

                        170       180       190
                 ....*....|....*....|....*....|....*.
gi 558757381 231 TGKDREKSHSwlSTGWFTMVIAVELCDHVHVYGMVP 266
Cdd:cd23985  177 SPEEIQPNPP--SSGMLGIILMMTLCDQVDVYEFLP 210
GT29_ST3GAL1_2 cd23966
beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from ...
 102-264 3.75e-14

beta-galactoside alpha-2,3-sialyltransferase 1 and 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL1 and 2 preferentially utilize the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1O-glycans) and on glycolipids as an acceptor substrate, respectively. Members ofthis family belong to glycosyltransferase family 29.


Pssm-ID: 467694  Cd Length: 276  Bit Score: 71.93  E-value: 3.75e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVahssvfrvlrRPQEFVNRTPETVFI 181
Cdd:cd23966   74 PNRCRRCAVVGNSGNLRGSRYGKLIDSHDFVIRMNKAPTKGFEKDVGSKTTHHFM----------YPESAVDLDPGVHLV 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 182 ---FwgppskmqKPQGslvrvIQRAGLVFPNMEAyAVSPGRMRQFDDLfrgetgkDREK-----------SH-SWL---- 242
Cdd:cd23966  144 lvpF--------KVLD-----LQWLISALTTGEI-TRTYTPVKRFIKA-------DKDKvlvinpafikyVHdNWTehhg 202

                        170       180
                 ....*....|....*....|....*
gi 558757381 243 ---STGWFTMVIAVELCDHVHVYGM 264
Cdd:cd23966  203 rypSTGFLALIFALHICDEVSVFGF 227
GT29_ST3GAL4 cd23982
beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from ...
 104-268 5.89e-13

beta-galactoside alpha-2,3-sialyltransferase 4; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL4 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,4GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467710  Cd Length: 204  Bit Score: 67.00  E-value: 5.89e-13
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVV-AHSSVFrvlrRPQEfvNRTPETVF-- 180
Cdd:cd23982    1 RCRRCVVVGNGHNLKNSSLGDVIDSYDVVIRLNDAPVRGFEKDVGSKTTIRLFyPESAQF----DPGI--ENDPDTLLvl 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 181 -----------------------IFWGPPSKMQKPQGSLVRVIqraglvfpnmeayavSPGRMRQFDDLFRGETGKDREK 237
Cdd:cd23982   75 vpfkpldfywlyeilsnekrvrkGFWKQPPRIWDANPKQIRIL---------------NPYYTYVAATKLLQVPGQRKKK 139

                        170       180       190
                 ....*....|....*....|....*....|.
gi 558757381 238 SHSwlSTGWFTMVIAVELCDHVHVYGMVPPN 268
Cdd:cd23982  140 QKP--TTGLLAITLALHLCDEVHIAGFGYPD 168
GT29_ST3GAL1 cd23980
beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from ...
 76-263 6.31e-12

beta-galactoside alpha-2,3-sialyltransferase 1; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL1 preferentially utilizes the Galbeta1,3GalNAc on O-glycans of glycoproteins (core1 O-glycans) as an acceptor substrate. Members of this family belong to glycosyltransferase family29 (GT29).


Pssm-ID: 467708  Cd Length: 280  Bit Score: 65.29  E-value: 6.31e-12
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  76 RSRRPVNLKK-----WSITDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNK 150
Cdd:cd23980   48 REKKPKNLNDtirelFQVVPGNVDPLLEKR-LVSCRRCAVVGNSGNLKESYYGPQIDSHDFVLRMNKAPTEGFEADVGSK 126

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 151 TTYRVVAHSSvFRVLRRPQEFVNRTPETVFIFW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQ- 222
Cdd:cd23980  127 TTHHFVYPES-FRELAQNVSMILVPFKTLDLEWvisatttGTISHTYVPVPRKIKVKKEKILIY--------HPAFIKYv 197

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|.
gi 558757381 223 FDDLFRGEtGKdrekshsWLSTGWFTMVIAVELCDHVHVYG 263
Cdd:cd23980  198 FDRWLQGH-GR-------YPSTGILSVIFSLHVCDEVDLYG 230
GT29_ST3GAL5 cd23983
beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from ...
 105-155 6.44e-12

beta-galactoside alpha-2,3-sialyltransferase 5; ST3GAL family transfers sialic acid from CMP-Sia to the terminalgalactose residues of glycochains through an 2,3-linkage. ST3GAL5 is also known as GM3 ganglioside synthase. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467711  Cd Length: 211  Bit Score: 64.37  E-value: 6.44e-12
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|.
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRV 155
Cdd:cd23983    2 CRRCVVVGSGGILHGLELGHLLDQFDIVIRLNNAPVQGYSQDVGNKTTIRM 52
GT29_ST3GAL6 cd23984
beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from ...
 105-263 6.55e-11

beta-galactoside alpha-2,3-sialyltransferase 6; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL6 utilizes the Galbeta1,4GlcNAc on glycoproteins and glycolipids as an acceptor. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467712  Cd Length: 206  Bit Score: 61.30  E-value: 6.55e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 105 CHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVF-------------------RVL 165
Cdd:cd23984    2 CKKCVVVGNGGVLRNKSLGKKIDSYDVIIRMNNGPVIGYENDVGKRTTFRLCYPESIFsdpshydpnttvvlipfkpHDL 81

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 166 RRPQEFVNRTPETVFIFW-GPPSKMQ-KPqgSLVRVIqraglvfpnmeayavSPGRMRQFD-DLFRGETGKDREKSHSWL 242
Cdd:cd23984   82 RWLLDLLMGKKVSAKGFWkKPALNLIyKP--NQIRIL---------------NPFILRIAAyELLHFPKRFPKEKKPKHP 144

                        170       180
                 ....*....|....*....|.
gi 558757381 243 STGWFTMVIAVELCDHVHVYG 263
Cdd:cd23984  145 TTGIIAITLALHICNEVHIAG 165
GT29_ST3GAL2 cd23979
beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from ...
 102-263 3.02e-10

beta-galactoside alpha-2,3-sialyltransferase 2; ST3GAL family transfer sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL2 preferentially utilizes the Galbeta1,3GalNAc on glycolipids as an acceptor substrate. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467707  Cd Length: 279  Bit Score: 60.27  E-value: 3.02e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 102 PSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVfRVLRRPQEFVNRTPETVFI 181
Cdd:cd23979   77 PSRCRRCAVVGNSGNLRGSGYGKDIDGHDFIMRMNQAPTVGFEADVGSRTTHHFMYPESA-KNLPANVSFVLVPFKTLDL 155

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 182 FW-------GPPSKMQKPQGSLVRVIQRAGLVFpnmeayavSPGRMRQFDDLFRGETGKdrekshsWLSTGWFTMVIAVE 254
Cdd:cd23979  156 LWitsalstGQIRFTYAPVKQFLRVDKDKVQIY--------NPAFFKYIHDRWTEHHGR-------YPSTGMLVLFFALH 220


                 ....*....
gi 558757381 255 LCDHVHVYG 263
Cdd:cd23979  221 VCDEVNVYG 229
GT29_ST8SIA_poly cd23969
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be ...
 108-266 5.24e-09

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2 and 4; ST8Sia2 and 4 are known to be polysialyltransferases, and they can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467697  Cd Length: 276  Bit Score: 56.65  E-value: 5.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRTPETVF------- 180
Cdd:cd23969   67 CAVVGNSGILLNSGCGQEIDSHDFVIRCNLAPVEGYEKDVGTKSNL-TTMNPSV--IPHAYGDLVNATDKEKFverlrql 143

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 181 ---IFWgPPSKMQKPQGSLVRVIQRAGL--VFPNMEAYAvsPGRMRQfddLFRG--ETGKDREKSHswlSTGWFTMVIAV 253
Cdd:cd23969  144 gdsILW-IPAFVSKGGEEHVQWTNEIILkhKLNVKTAYP--PLRLNH---AIRGywLTTKFRIKRP---STGLLMYTLAT 214

                        170
                 ....*....|...
gi 558757381 254 ELCDHVHVYGMVP 266
Cdd:cd23969  215 RFCDEIHLYGFYP 227
GT29_ST3GAL3 cd23981
beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from ...
 104-184 1.76e-08

beta-galactoside alpha-2,3-sialyltransferase 3; ST3GAL family transfers sialic acid from CMP-Sia to the terminal galactose residues of glycochains through an 2,3-linkage. ST3GAL3 can utilize both Galbeta1,3GlcNAc and Galbeta1,4GlcNAc, mainly on glycoproteins and oligosaccharidesas acceptor substrates, but prefers the Galbeta1,3GlcNAc. Members of this family belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467709  Cd Length: 207  Bit Score: 54.16  E-value: 1.76e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 104 RCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSvfrVLRRPQEFvnrTPETVFIFW 183
Cdd:cd23981    1 SCRRCIIVGNGGVLANKSLGSKIDDYDVVVRLNSAPVKGFEKDVGSKTTLRITYPEG---AIQKPEQY---EKDSLFVLA 74


                 .
gi 558757381 184 G 184
Cdd:cd23981   75 G 75
GT29_ST6GALNAC1_2 cd23964
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members ...
 89-269 5.68e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 and 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 and 2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467692  Cd Length: 292  Bit Score: 53.42  E-value: 5.68e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  89 TDGYVPILGNKTlPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRP 168
Cdd:cd23964   67 TSSRYMFVLRGG-RPRCIRCAVVGNGGILNGSGKGKEIDAHDYVFRVNHALTKGFEKDVGTKTSFYTFFPESLHNSLLKH 145

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 169 qefVNRTPETVFIF----------------WGPPSKMQKPQGSlvrviqraglvFPNMEAYAVSPGRMRQFD-DLFRget 231
Cdd:cd23964  146 ---VPQDKDTKYLFipfkirdydyldavlsGKPVPDGCDKGKR-----------PPPLFGPKLNATNVRLLHpDFIR--- 208

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|
gi 558757381 232 gkdreksH---SWL--------STGWFTMVIAVELCDHVHVYGM-VPPNY 269
Cdd:cd23964  209 -------YlfnRWLnsstsyrpTTGALMLLTALHTCDQVSVYGFgYDPRF 251
GT29_ST6GALNAC1 cd23973
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are ...
 103-269 6.56e-08

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc1 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467701  Cd Length: 309  Bit Score: 53.60  E-value: 6.56e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 103 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF----VNRTPET 178
Cdd:cd23973   81 DGCIRCAVVGNGGILNGSKMGQEIDSHDYVFRVNGAVIKGYEEDVGTRTSFYVHTAHSITSSLMILQKRgfknIPQDKDI 160

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 179 VFIF---------WGPPSKMQK--PQGSLVRVIQRA--GLVFpNMEAYAVS-PGRMRQFDDLFRgeTGKDREKSHSWL-- 242
Cdd:cd23973  161 KYILfpegprdyqWLEALLKNKtiPSGAYYGRRPRSyfSGDF-TEDKYLVLhPDFLRYVKNRFL--RSKTLKGKYWAIyr 237

                        170       180
                 ....*....|....*....|....*...
gi 558757381 243 -STGWFTMVIAVELCDHVHVYGMVPPNY 269
Cdd:cd23973  238 pTTGAFLLLTALHLCDTVSAYGFITEDY 265
GT29_ST8SIA_mono cd23971
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are ...
 107-266 7.15e-08

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 1, 5 and 6; ST8 Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The family is subdivided into 3 classes of enzymes, depending on theircatalytic activiy, the mono-STs (ST8Sia1, ST8Sia5 and ST8Sia6), the oligo-ST(ST8Sia3), and the poly-STs (ST8Sia2 and ST8Sia4). The ST8Sia family belongs to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467699  Cd Length: 271  Bit Score: 53.03  E-value: 7.15e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 107 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTgYSADVGNKTTYrVVAHSSVFR-----VLRRPQEFVNRtpetvfi 181
Cdd:cd23971   66 TCAVVGNGGILKNSSCGREIDSADFVIRCNLPPLN-DSKDVGSKTNL-VTANPSILRekfhnLKKRRRPFVER------- 136

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 182 fwgppskMQKPQGSLV------------------RVIQRAGlvfPNMEAYAVSPGRMRQFDDLFRGETGKDREkshswLS 243
Cdd:cd23971  137 -------MKVYGNALLllpafsytsntepslralYTLEDFG---SPQKVLFFNPEYLRNLSRYWKSKGLKARR-----LS 201

                        170       180
                 ....*....|....*....|....
gi 558757381 244 TGwFTMV-IAVELCDHVHVYGMVP 266
Cdd:cd23971  202 TG-LMLVsAALELCENVHLYGFWP 224
GT29_ST8SIA6 cd23991
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2, ...
 107-266 1.42e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6; alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 6 (also known as alpha-2,8-sialyltransferase 8F) prefers O-glycans to N-glycans or glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia. The ST8Sia family belongs to glycosyltransferase family 29(GT29).


Pssm-ID: 467719  Cd Length: 273  Bit Score: 52.06  E-value: 1.42e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 107 QCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTG-YSADVGNKTTYrVVAHSSVFrvLRRPQEFVNRtpetvfifwgp 185
Cdd:cd23991   66 QCAVVGNGGILKNSSCGAEIDQADFVFRCNLPPTGGnISKDVGSKTNL-VTANPSII--SIKYAKLNER----------- 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 186 pskmQKPQGSLVRVIQRAGLVFPnmeAYAVSPGRMRQFDDLFRGETGKDREK------------SHSW---------LST 244
Cdd:cd23991  132 ----RKPFLETVSVYGDAFLLLP---AFSYRSNTALSFKVYYTLEDFKAKQKviffhpiylkhlAQFWrskgvqvyrLST 204

                        170       180
                 ....*....|....*....|..
gi 558757381 245 GWFTMVIAVELCDHVHVYGMVP 266
Cdd:cd23991  205 GLMITSAALELCEEVKLYGFWP 226
GT29_ST8SIA2 cd23987
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase ...
 96-266 3.02e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 2; ST8Sia2 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia2 catalyzes shorter polysialic acid formation of NCAMs than ST8Sia4. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467715  Cd Length: 278  Bit Score: 51.48  E-value: 3.02e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  96 LGNKTLPSrchqCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYrVVAHSSVfrVLRRPQEFVNRT 175
Cdd:cd23987   59 LKNKHFKT----CAIVGNSGILLNSGCGREIDSHDFVIRCNLAPVEEYAKDVGTKTDL-VTMNPSV--VQRAFEDLVNET 131

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 176 PETVFIfwgppSKMQKPQGSLVRViqraglvfpnmEAYAVSPG--RMRQFDDLFRGETGKDREKSHS----------WL- 242
Cdd:cd23987  132 WKEKFL-----QRLQSLNGSILWI-----------PAFMAKGGeeRVEWVNDLILKHHINVRTAYPSlrllhavrgyWLt 195

                        170       180       190
                 ....*....|....*....|....*....|..
gi 558757381 243 --------STGWFTMVIAVELCDHVHVYGMVP 266
Cdd:cd23987  196 nkvhikrpTTGLLMYTLATRFCNRIHLYGFWP 227
GT29_ST8SIA4 cd23988
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase ...
 40-266 4.58e-07

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 4; ST8Sia4 is a polysialyltransferase that can synthesize polysialic acid on neural cell adhesion molecules (NCAMs). ST8Sia4 catalyzes longer polysialicacid formation of NCAMs than ST8Sia2. ST8Sia family members are alpha-N-acetylneuraminide alpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acid and the terminal sialic acid residues of glycochains, by transfering sialic acid from CMP-Sia and they belong to the glycosyltransferase family 29 (GT29).


Pssm-ID: 467716  Cd Length: 278  Bit Score: 50.72  E-value: 4.58e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381  40 EQRSAVFVILFALITILILYSSNSANEVFHYGSLRgrsRRPVNLKK--WSITDGYVPiLGNKTLPSrchqCVIVSSSSHL 117
Cdd:cd23988    5 EIRKDILRFLDAERDVSVVKSSFKPGDVIHYVLDR---RRTLNISQnlHSLLPEVSP-MKNRRFKT----CAVVGNSGIL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 118 LGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRV---LRRP---QEFVNRTPE-TVFIFWgPPSKMQ 190
Cdd:cd23988   77 LDSGCGKEIDSHDFVIRCNLAPVVEFAADVGTKSDFITMNPSVVQRAfggFRNEsdrEKFVHRLSMlNDSVLW-IPAFMV 155

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 558757381 191 KpqGSLVRVIQRAGLVFPNMEAYAVSPGRMRQFDDLfRGE--TGKDREKSHswlSTGWFTMVIAVELCDHVHVYGMVP 266
Cdd:cd23988  156 K--GGEKHVEWVNALILKNKLKVRTAYPSLRLIHAV-RGYwlTNKVNIKRP---STGLLMYTLATRFCDEIHLYGFWP 227
GT29_ST8SIA3_oligo cd23970
alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2, ...
 108-266 8.17e-06

alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3; Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase 3 synthesizes polysialic acid and has been shown to autopolysialylate. ST8Sia3 utilizes the Siaalpha2,3Galbeta1,4GlcNAc structure on N-glycans of glycoproteins and glycolipids as acceptor substrates. ST8Sia family members are alpha-N-acetylneuraminidealpha-2,8-sialyltransferases that catalyze an alpha-2,8-linkage between sialic acidand the terminal sialic acid residues of glycochains, by transfering sialic acidfrom CMP-Sia and they belong to glycosyltransferase family 29 (GT29).


Pssm-ID: 467698  Cd Length: 284  Bit Score: 47.00  E-value: 8.17e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 108 CVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVA-------HSSVFRVLRRPQEFVNRTPETVF 180
Cdd:cd23970   71 CAVVGNSGILTNSQCGNEIDKSDFVFRCNFAPTEGFEKDVGRKTNLTTFNpsilekyYNNLLTIQDRNNFFLSLKKLDGA 150

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 181 IFWGPPSKMQKpqgslVRVIQRAGLVF-------PNME-AYavsPGR-MRQFDDLFRGETGKDREkshswLSTGWFTMVI 251
Cdd:cd23970  151 ILWIPAFFFHT-----SATVTRTLVDFfvehrgqLKVQlAW---PGNiMQHVNRYWKTKHLSPKR-----LSTGILMYTL 217

                        170
                 ....*....|....*
gi 558757381 252 AVELCDHVHVYGMVP 266
Cdd:cd23970  218 ASAICEEIHLYGFWP 232
GT29_ST6GALNAC2 cd23972
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are ...
 101-269 2.09e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. ST6GalNAc2 utilize mainly GalNAc-,Galbeta1,3GalNAc-, and Sia2,3Galbeta1,3GalNAc on O-glycans of glycoproteins as acceptors. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467700  Cd Length: 308  Bit Score: 45.97  E-value: 2.09e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 101 LPSRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRRPQEF-VNRTPET- 178
Cdd:cd23972   78 TPGKCIRCAVVGNGGILNGSRQGRAIDAHDYVFRLNGAVIKGFEEDVGTKTSFYGFTVNTMKNSLISYWNLgFTRTPQGq 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 179 ----VFIfwgpPSKMQK-------------PQGsLVRVIQRAGLVFPNMEAYA---VSPGRMRQFDDLFRGETGKDREKS 238
Cdd:cd23972  158 dlqyIFI----PSDIRDyvmlrsailgvpvPEG-LDKGDRPHKYFGPEASAKKfklLHPDFISYLTDRFLKSKLLNTHYG 232

                        170       180       190
                 ....*....|....*....|....*....|..
gi 558757381 239 HSWL-STGWFTMVIAVELCDHVHVYGMVPPNY 269
Cdd:cd23972  233 HLYMpSTGALMLLTALHTCDQVSAYGFITSNY 264
GT29_ST6GALNAC2L cd23974
alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are ...
 103-269 6.45e-05

alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 2-like; ST6GalNAc family members are alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferases that catalyze an alpha-2,6-linkage between sialic acid and the N-acetylgalactosamine residues of glycochains through an 2,6-linkage, by transfering sialic acid from CMP-Sia. The ST6GalNac family belongs to glycosyltransferase family 29 (GT29).


Pssm-ID: 467702  Cd Length: 309  Bit Score: 44.36  E-value: 6.45e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 103 SRCHQCVIVSSSSHLLGTKLGPEIERAECTIRMNDAPTTGYSADVGNKTTYRVVAHSSVFRVLRR---------PQefvn 173
Cdd:cd23974   82 SPCIRCAVVGNGGILNGSRMGAEIDGHDYVFRVNGAITKGFEKDVGRRTSFYTFSTNTLMNSLRAyagvgfngpPQ---- 157

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558757381 174 rTPETVFIFWgP---------------------PSKMQKPQ---GSLVRViqraglvfpnmEAYAV-SPGRMRQFDDLF- 227
Cdd:cd23974  158 -SKETRYIFL-PdhdrdyllvkaalthtpidrgRDKSKRPSkyfGKDVTA-----------EKFKIyHPDFIRYLRNRFl 224

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|..
gi 558757381 228 RGETGKDREKSHSWLSTGWFTMVIAVELCDHVHVYGMVPPNY 269
Cdd:cd23974  225 WSPILNTKQRDIYRPSTGAVMLLAALHTCDQVSAYGFMTPDY 266
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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