NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|558472750|ref|NP_001273758|]
View 

nicotinate phosphoribosyltransferase isoform 2 [Homo sapiens]

Protein Classification

beta/alpha barrel domain-containing protein( domain architecture ID 229392)

beta/alpha barrel domain-containing protein belongs to a large superfamily with a wide variety of enzymatic functions

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
TIM super family cl21457
TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate ...
 15-512 0e+00

TIM-like beta/alpha barrel domains; A large family of domains similar to triose phosphate isomerase (TIM) which, in general, share an eight beta/alpha closed barrel structure.


The actual alignment was detected with superfamily member PLN02885:

Pssm-ID: 473867 [Multi-domain]  Cd Length: 545  Bit Score: 603.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885  12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885  92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 413 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQEL-----------------RV-------WPPGAQEPctvrpa 468
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGERIlcrhpfneskrayvvpqRVeellkcyWDGSSGKP------ 485

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 558472750 469 qlCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 512
Cdd:PLN02885 486 --REELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-512 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 603.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885  12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885  92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 413 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQEL-----------------RV-------WPPGAQEPctvrpa 468
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGERIlcrhpfneskrayvvpqRVeellkcyWDGSSGKP------ 485

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 558472750 469 qlCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 512
Cdd:PLN02885 486 --REELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-512 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 587.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  415 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTV---RPAQLCEPLPSLAESRALAQLSLSRL 491
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQEKCTPVFAPVEPLLRlvmKNGQRVRPLPSLAEIRARAREQLSKL 422

                         490       500
                  ....*....|....*....|.
gi 558472750  492 SPEHRRLRSPAQYQVVLSERL 512
Cdd:TIGR01513 423 PPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-398 7.47e-164

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 467.44  E-value: 7.47e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570    1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570   79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570  157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570  202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558472750 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLV 398
Cdd:cd01570  271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-519 5.52e-138

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 406.07  E-value: 5.52e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488    6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488   84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488  162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488  205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLT 409
Cdd:COG1488  272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLS 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 410 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGQELrvwppgaQEPCtVRPAQLCEPLPSLAESRALAQLSLS 489
Cdd:COG1488  345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEPEPL-------LVPV-FRDGKLVYELPSLEEIRERAAAQLA 415

                        490       500       510
                 ....*....|....*....|....*....|
gi 558472750 490 RLSPEHRRLRSPAQYQVVLSERLQALVNSL 519
Cdd:COG1488  416 ELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.03e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.13  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 558472750   96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
 
Name Accession Description Interval E-value
PLN02885 PLN02885
nicotinate phosphoribosyltransferase
 15-512 0e+00

nicotinate phosphoribosyltransferase


Pssm-ID: 178473 [Multi-domain]  Cd Length: 545  Bit Score: 603.96  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPDTDPAFFE 94
Cdd:PLN02885  12 PLLTDLYQFTMAYAYWKAGKHLDRAVFDLFFRKNPFGGEYTVFAGLEECLRFIANFKFTDDDIDFLRSVMPSGCEDAFFD 91

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKRLLEMGLRRAQ 174
Cdd:PLN02885  92 YLRGLDCSDVEVYAIPEGSVVFPRVPLMRIEGPLAVVQLLETTFLTLVNYASLVATNAARHRLVAGKSKVLLEFGLRRAQ 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVPPDPMLAPAAGEGPGVDLAAKAQVWLE--Q 252
Cdd:PLN02885 172 GPDGGISASKYCYLGGFDATSNVEAGRLFGIPVRGTHSHAFVSSYMGLDEIVDKTLRSADGSSVCEDFVSLVQEWLSklQ 251

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 253 VCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIR 332
Cdd:PLN02885 252 ESSSLRGVFSETNQSELAAFTSYALAFPNSFLALVDTYDVMKSGIPNFCAVALALNDLGYKAVGIRLDSGDLAYLSLEAR 331

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 333 KVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDP 412
Cdd:PLN02885 332 KFFRTIEEELGVPGFGKMSITASNDINEETLDALNKQGHEIDAFGIGTHLVTCYAQPALGCVYKLVEINGQPRIKLSEDV 411

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 413 EKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQEL-----------------RV-------WPPGAQEPctvrpa 468
Cdd:PLN02885 412 EKVTIPCKKRCYRLYGKEGYPLVDLMTGENEPPPKVGERIlcrhpfneskrayvvpqRVeellkcyWDGSSGKP------ 485

                        490       500       510       520
                 ....*....|....*....|....*....|....*....|....
gi 558472750 469 qlCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 512
Cdd:PLN02885 486 --REELPSLKEIRERCMKQLERMRPDHMRRLNPTPYKVSVSAKL 527
NAPRTase_put TIGR01513
putative nicotinate phosphoribosyltransferase; A deep split separates two related families of ...
 15-512 0e+00

putative nicotinate phosphoribosyltransferase; A deep split separates two related families of proteins, one of which includes experimentally characterized examples of nicotinate phosphoribosyltransferase, an the first enzyme of NAD salvage biosynthesis. This model represents the other family. Members have a different (longer) spacing of several key motifs and have an additional C-terminal domain of up to 100 residues. One argument suggesting that this family represents the same enzyme is that no species has a member of both families. Another is that the gene encoding this protein is located near other NAD salvage biosynthesis genes in Nostoc and in at least four different Gram-positive bacteria. NAD and NADP are ubiquitous in life. Most members of this family are Gram-positive bacteria. An additional set of mutually closely related archaeal sequences score between the trusted and noise cutoffs. [Biosynthesis of cofactors, prosthetic groups, and carriers, Pyridine nucleotides]


Pssm-ID: 273666 [Multi-domain]  Cd Length: 443  Bit Score: 587.79  E-value: 0e+00
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFE 94
Cdd:TIGR01513   1 ALLTDLYELTMAQGYFREGKANQPAVFEVFFRKLPFGRGYAVFAGLEDLLEFLENFRFDAEDIEYLASL--GIFDDAFLD 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   95 HLRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPEKrLLEMGLRRAQ 174
Cdd:TIGR01513  79 YLREFRFS-GTVRALPEGSLVFPNEPLLQVEGPLIEAQLLETLVLNIINFQTLIATKAARIVLAAGGKP-LLEFGLRRAQ 156

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:TIGR01513 157 GPDAALKAARAAYIGGADGTSNVLAGRLYGIPVSGTMAHSFVMSF----------------------------------- 201

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYrAVGVRLDSGDLLQQAQEIRKV 334
Cdd:TIGR01513 202 -----------DNELAAFRAYAKLYPKATVLLVDTYDTLRSGLPNAIAVAKELGEQGK-VVGVRIDSGDLLYLSKQARKQ 269

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEK 414
Cdd:TIGR01513 270 LDAAG-------LTQVKIVVSNDLDENSIAALKAEGAPIDVYGVGTSLVTASDAPALGGVYKLVAYEGRPVMKLSENPEK 342

                         410       420       430       440       450       460       470       480
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  415 QTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTV---RPAQLCEPLPSLAESRALAQLSLSRL 491
Cdd:TIGR01513 343 STLPGRKQVFRLYDATGKFLGDELTLADEPIEDLNQEKCTPVFAPVEPLLRlvmKNGQRVRPLPSLAEIRARAREQLSKL 422

                         490       500
                  ....*....|....*....|.
gi 558472750  492 SPEHRRLRSPAQYQVVLSERL 512
Cdd:TIGR01513 423 PPEYLRLLNPHVYPVSLSPRL 443
NAPRTase_A cd01570
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate ...
 15-398 7.47e-164

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup A. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria and eukaryota (except funghi).


Pssm-ID: 238804 [Multi-domain]  Cd Length: 327  Bit Score: 467.44  E-value: 7.47e-164
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdtDPAFFE 94
Cdd:cd01570    1 ALLTDLYQLTMAQAYWKEGKHNKPAVFELFFRKLPFGGGYAVFAGLEELLEYLENFRFTEEDIDYLRSLGIF--DEEFLD 78

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDcSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGPeKRLLEMGLRRAQ 174
Cdd:cd01570   79 YLRGFR-FTGTIYAIPEGEVVFPNEPLLTVEGPLIEAQLLETLLLNLINFQTLIATKAARVRLAAGG-RPLLEFGLRRAQ 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:cd01570  157 GPDAALSAARAAYIGGFDGTSNVLAGKLYGIPVSGTMAHSFVQAF----------------------------------- 201

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:cd01570  202 -----------DDELAAFRAFAEAYPDNFTLLVDTYDTLRSGLPNAIAVAKELGALGYRLVGVRIDSGDLAYLSKEARKM 270

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 558472750 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLV 398
Cdd:cd01570  271 LDEAG-------LTKVKIVASNDLDEYTIAALNAQGAPIDAFGVGTRLVTSQSQPALGGVYKLV 327
PRK09243 PRK09243
nicotinate phosphoribosyltransferase; Validated
 15-512 2.81e-142

nicotinate phosphoribosyltransferase; Validated


Pssm-ID: 236426 [Multi-domain]  Cd Length: 464  Bit Score: 417.64  E-value: 2.81e-142
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASvlPPDTDPAFFE 94
Cdd:PRK09243  10 ALLTDLYELTMAQAYLRDGIHNRRAVFELFFRKLPFGRGYAVFAGLERLLEYLENLRFTEEDIEYLRS--LGIFDEDFLD 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDCSEvTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQ 174
Cdd:PRK09243  88 YLRNFRFTG-DVRAVPEGELVFPNEPLLRVEGPLAEAQLLETLLLNIINFQTLIATKAARIVSAAG-GRPLLEFGSRRAQ 165

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK09243 166 GPDAAVWAARAAYIGGFDATSNVLAGKRYGIPVSGTMAHSFVQA------------------------------------ 209

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 255 ahlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK09243 210 ----------FDDEYEAFRAYAETYPDNTVLLVDTYDTLKSGVPNAIKVAKELGD-GIELGGVRIDSGDLAYLSKKVRKM 278

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLTE 410
Cdd:PRK09243 279 LDEAG-------FTDTKIVASNDLDEYTIASLKLQGAPIDGFGVGTKLVTGSDAPALGGVYKLVAIEGeggmIPKIKLSN 351

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 411 DPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPV--------PQAGQELRVWPPGAQEPCTV---RPAQLCEPLPSLAE 479
Cdd:PRK09243 352 SPEKVTTPGRKQVYRIYDKGGKAEADVITLADEEEeeplkmfhPVHTYKSKTVKNFDAEPLLVpvmENGKRVYELPSLEE 431

                        490       500       510
                 ....*....|....*....|....*....|...
gi 558472750 480 SRALAQLSLSRLSPEHRRLRSPAQYQVVLSERL 512
Cdd:PRK09243 432 IRAYAAAQLASLPEEYKRLLNPHAYPVDLSQAL 464
PncB COG1488
Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid ...
 16-519 5.52e-138

Nicotinic acid phosphoribosyltransferase [Coenzyme transport and metabolism]; Nicotinic acid phosphoribosyltransferase is part of the Pathway/BioSystem: NAD biosynthesis


Pssm-ID: 441097 [Multi-domain]  Cd Length: 445  Bit Score: 406.07  E-value: 5.52e-138
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  16 LLTDLYQATMALGYWRAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVlpPDTDPAFFEH 95
Cdd:COG1488    6 LLTDLYKLTMAQAYLPEGTANRRAVFELFFRRLPFGRGYVVFAGLQRFLKYLENLRFTEEDIAYLRSL--GVFDEDFLDY 83

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  96 LRALDCSeVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRRAQG 175
Cdd:COG1488   84 LADFRFP-GDIRAVPEGTVVFPGEPLLTVEGTLPEAQLLETLLLNILNYPTLIATKAARIVQAAG-GRPLHDFGLRRAHG 161

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 176 PDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSfsgsevppdpmlapaagegpgvdlaakaqvwleqvca 255
Cdd:COG1488  162 LEAAVAAARAAYLAGFAGTSNVLAGRYYGIPSVGTMAHSFVQA------------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 256 hlglgvqepHPGERAAFVAYALAFPRAFQGLLDTYSVWrSGLPNflAVALAlGELG--YRAVGVRLDSGDLLQQAQEIRK 333
Cdd:COG1488  205 ---------HDDELEAFRAFAEAYPDGTTLLVDTYDTL-SGVPN--AIELA-KELLarGGLLGIRLDSGDLAYLSKQARE 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 334 VFRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGG----QPRMKLT 409
Cdd:COG1488  272 LLDEAG-------LPDVRIIASDDLDEYRIAALLEQGAPIDVFGVGTRLVTSSDRPTLGFVYKLVAVEGdgewRPVIKLS 344

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 410 EDPEKQTLPGSKAAFRlLGSDGSPLMDMLQLAEEPVPQAGQELrvwppgaQEPCtVRPAQLCEPLPSLAESRALAQLSLS 489
Cdd:COG1488  345 ETPGKKSKPGRKQVYR-RDEDGKATADLVALEDEPLPGEPEPL-------LVPV-FRDGKLVYELPSLEEIRERAAAQLA 415

                        490       500       510
                 ....*....|....*....|....*....|
gi 558472750 490 RLSPEHRRLRSPAQYQVVLSERLQALVNSL 519
Cdd:COG1488  416 ELPEELKRLRNPPAYPVDLSEALWDLKEQL 445
PRK12484 PRK12484
nicotinate phosphoribosyltransferase; Provisional
 16-521 1.27e-104

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 237112 [Multi-domain]  Cd Length: 443  Bit Score: 320.54  E-value: 1.27e-104
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  16 LLTDLYQATMALGYWRAGrARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLP-PDTDPAFFE 94
Cdd:PRK12484   6 LLTDLYEVTMANAYLREG-MSAPATFSLFYRKLPDGRGFLIAAGLADVVEFLEAFRFDEQDLRYLRGLNQfSEEFLAWLA 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRaLDCSevtVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLiAGPEKRLLEMGLRRAQ 174
Cdd:PRK12484  85 GLR-FTGD---VRAVPEGTVVFPNEPLLEVTAPLIEAQLVETFLLNQINHQSLIASKAARCVL-AAAGRPVVDFGARRAH 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 175 GPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvc 254
Cdd:PRK12484 160 GTDAACYVARASYLAGAAGTSNVLAARQYGIPASGTMAHSFVEAF----------------------------------- 204

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 255 ahlglgvqephPGERAAFVAYALAFPRAFQGLLDTYSVWRsGLPNFLAVALALGElGYRAVGVRLDSGDLLQQAQEIRKV 334
Cdd:PRK12484 205 -----------PDEVAAFRAFARLYPDATTLLVDTYDTLR-GVRNAIEVAKELGN-RFDPRGVRLDSGDLAELSKATRAI 271

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTedPEK 414
Cdd:PRK12484 272 LDAAG-------LEQVKIVASGGLDEYRIAALLAAGAPIDGFGVGTRLGVAADAPVLDSAYKLVAYEGRGVTKLS--SGK 342

                        410       420       430       440       450       460       470       480
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 415 QTLPGSKAAFRLLGSdGSPLMDMLQLAEEPVPQAGQELRVwPPGAQEPCTVRPaqlceplPSLAESRALAQLSLSRLSPE 494
Cdd:PRK12484 343 VTYPGRKQVFRLYEH-GTACGDVIGLHTENIPDGREPLLV-PVMTNGRRIQHA-------PTLDGARDWCEAQLAALPPE 413

                        490       500
                 ....*....|....*....|....*..
gi 558472750 495 HRRLRSPAQYQVVLSERLQALVNSLCA 521
Cdd:PRK12484 414 ARRLVDPVAVSVTLSGELARLRHADTA 440
NAPRTase_PncB cd01567
Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase ...
 15-396 1.38e-100

Nicotinate phosphoribosyltransferase (NAPRTase) family. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238801 [Multi-domain]  Cd Length: 343  Bit Score: 306.89  E-value: 1.38e-100
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  15 PLLTDLYQATMALGYWrAGRARDAAEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPpdtDPAFFE 94
Cdd:cd01567    1 LLDTDLYKLTMMQAYL-YPYPNTRVVFEFTFRSNPFGGDYIVFAGLEEVLKLLENLRFTEEEIEYLKKLLI---FGEFFL 76

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  95 HLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAG-----------PEK 163
Cdd:cd01567   77 YLLFLGKLPLEIYALPEGTVVFPKEPLLTIEGPWPEAGLLETPLLAIWNEATSIATKAARKKLAAGglletkdnleeLGF 156

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 164 RLLEMGLRRAQGPDGGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdla 243
Cdd:cd01567  157 KLHDFGTRRRHSPEAALSGGRAALIGGFGGTSNVAAAKKLGIPPIGTMAHSWIQAFGALEE------------------- 217

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 244 akaqvwleqvcahlglgvqephpgerAAFVAYALAFPRAFQGLL----DTYSVWRsGLPNFLAVALALGElGYRAVGVRL 319
Cdd:cd01567  218 --------------------------AAFEAFARWLPQFGGGLGialiDTYDTDN-GFLNALKLAKALGA-GGGLLGVRL 269

                        330       340       350       360       370       380       390
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 558472750 320 DSGDLLQQAQEIRKVFRAAAAqfqvpWLESVLIVVSNNID-EEALARL-AQEGSEVNVIGIGTSVVTCPQQPSLGGVYK 396
Cdd:cd01567  270 DSGDPVELIKKVRKHLDELGI-----DLNKKKIIISGDLDtEEAIELLlEQGASPNDAFGVGTSLTNDLGRPPLGFVYK 343
PRTase_typeII cd00516
Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an ...
 19-396 4.41e-56

Phosphoribosyltransferase (PRTase) type II; This family contains two enzymes that play an important role in NAD production by either allowing quinolinic acid (QA) , quinolinate phosphoribosyl transferase (QAPRTase), or nicotinic acid (NA), nicotinate phosphoribosyltransferase (NAPRTase), to be used in the synthesis of NAD. QAPRTase catalyses the reaction of quinolinic acid (QA) with 5-phosphoribosyl-1-pyrophosphate (PRPP) in the presence of Mg2+ to produce nicotinic acid mononucleotide (NAMN), pyrophosphate and carbon dioxide, an important step in the de novo synthesis of NAD. NAPRTase catalyses a similar reaction leading to NAMN and pyrophosphate, using nicotinic acid an PPRP as substrates, used in the NAD salvage pathway.


Pssm-ID: 238286 [Multi-domain]  Cd Length: 281  Bit Score: 188.99  E-value: 4.41e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  19 DLYQATMALGYwraGRARDAAEFELFFRRCPFGgafaLAAGLRDCVRFLRAFRLRDAdvqflasvlppdtdpaffehlra 98
Cdd:cd00516    1 DLYKLTMIQAY---PPPDTRATAEFTAREDPYG----VLAGLEEALELLELLRFPGP----------------------- 50

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  99 ldcseVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIA-GPEKRLLEMGLRRAQgPD 177
Cdd:cd00516   51 -----LVILAVPEGTVVEPGEPLLTIEGPARELLLLERVLLNLLQRLSGIATATARYVEAAkGANTKVHDFGTRKTT-PG 124

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 178 GGLTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsgsevppdpmlapaagegpgvdlaakaqvwleqvcahl 257
Cdd:cd00516  125 LRLLEKYAVLIGGGDGHRNGLSDAILIKDNHGTMAHSIIQAF-------------------------------------- 166

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 258 glgvqephpGERAAFVAYALAFPRAFQGLLDTYSVWrsgLPNFLAVALALgelgyRAVGVRLDSGDL--LQQAQEIRKVF 335
Cdd:cd00516  167 ---------GELAAVKALRRWLPELFIALIDVEVDT---LEEALEAAKAG-----GADGIRLDSGSPeeLDPAVLILKAR 229

                        330       340       350       360       370       380
                 ....*....|....*....|....*....|....*....|....*....|....*....|.
gi 558472750 336 RAaaaqFQVPWLESVLIVVSNNIDEEALARLAQEGseVNVIGIGTSVVTCpqqPSLGGVYK 396
Cdd:cd00516  230 AH----LDGKGLPRVKIEASGGLDEENIRAYAETG--VDVFGVGTLLHSA---PPLDIVLK 281
NAPRTase_N pfam17767
Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate ...
 16-143 1.03e-45

Nicotinate phosphoribosyltransferase (NAPRTase) N-terminal domain; Nicotinate phosphoribosyltransferase (EC:2.4.2.11) is the rate limiting enzyme that catalyzes the first reaction in the NAD salvage synthesis. This is the N-terminal domain of the enzyme.


Pssm-ID: 465494 [Multi-domain]  Cd Length: 125  Bit Score: 156.13  E-value: 1.03e-45
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750   16 LLTDLYQATMALGYWRAGRARDAaEFELFFRRCPFGGAFALAAGLRDCVRFLRAFRLRDADVQFLASVLPPdTDPAFFEH 95
Cdd:pfam17767   1 LDTDLYKLTMAQAYFKNGPDVQV-VFEFFNRTNPFGGLYAVFAGLEEQIEFLENLRFTEEEIEYLRRSLPY-FKPDFLDY 78

                          90       100       110       120
                  ....*....|....*....|....*....|....*....|....*...
gi 558472750   96 LRALDCSEVTVrALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVS 143
Cdd:pfam17767  79 LRNFRFDPSIV-AVPEGEVVFPGEPLLRIEGPWLETILLETPLLAIVN 125
NAPRTase_B cd01571
Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate ...
 94-407 1.55e-26

Nicotinate phosphoribosyltransferase (NAPRTase), subgroup B. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products.


Pssm-ID: 238805 [Multi-domain]  Cd Length: 302  Bit Score: 109.29  E-value: 1.55e-26
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  94 EHLRALDCSEVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR- 172
Cdd:cd01571   43 EVLALLEGLPVKVYALPEGTIFNPKEPVLRIEGPYQDFGELETAILGILARASSIATNAARVKLAAG-DKPVISFGDRRd 121

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 173 --AQGPDGGLTAstysYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFSGSEVppdpmlapaagegpgvdlaakaqvwl 250
Cdd:cd01571  122 hpAIQPMDGRAA----YIGGCDGVSTVLGAELLGEKPSGTMPHALIQIFGGDQV-------------------------- 171

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 251 eqvcahlglgvqephpgerAAFVAYALAFPRAFQ--GLLDTYSVWRsglpnfLAVALALGELGYRAVGVRLDS-----GD 323
Cdd:cd01571  172 -------------------EAWKAFDETYPEDVPriALIDTFNDEK------EEALKAAKALGDKLDGVRLDTpssrrGV 226

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 324 LLQQAQEIRKVFRAAAAQfqvpwleSVLIVVSNNIDEEALARLAQEGseVNVIGIGTSVVTCpqqPSLGGVYKLVAVGGQ 403
Cdd:cd01571  227 FRYLIREVRWALDIRGYK-------HVKIFVSGGLDEEDIKELEDVG--VDAFGVGTAISKA---PPVDFTMDIVEVNGQ 294


                 ....
gi 558472750 404 PRMK 407
Cdd:cd01571  295 PIAK 298
NAPRTase_C pfam17956
Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus ...
 421-515 2.88e-23

Nicotinate phosphoribosyltransferase C-terminal domain; This domain is found at the C-terminus of some Nicotinate phosphoribosyltransferase enzymes. The function of this domain is uncertain.


Pssm-ID: 465585 [Multi-domain]  Cd Length: 111  Bit Score: 94.56  E-value: 2.88e-23
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  421 KAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQ------EPCTVRP--------AQLCEPLPSLAESRALAQL 486
Cdd:pfam17956   2 KQVYRLYDKDGKAIADLITLADEPPPDPGEEILCFHPFDEwkrktvTPFTVEPllkpvfedGKLVYELPTLEEIRAYVQE 81

                          90       100
                  ....*....|....*....|....*....
gi 558472750  487 SLSRLSPEHRRLRSPAQYQVVLSERLQAL 515
Cdd:pfam17956  82 QLSRLWPEHKRLLNPHPYKVDLSEKLYQL 110
PRK08662 PRK08662
nicotinate phosphoribosyltransferase; Reviewed
 103-382 8.09e-19

nicotinate phosphoribosyltransferase; Reviewed


Pssm-ID: 236328 [Multi-domain]  Cd Length: 343  Bit Score: 87.62  E-value: 8.09e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 103 EVTVRALPEGSLAFPGVPLLQVSGPLLVVQLLETPLLCLVSYASLVATNAARLRLIAGpEKRLLEMGLRR---AQGPdgg 179
Cdd:PRK08662  69 PVDVYALPEGTLFDPKEPVMRIEGPYLEFGIYETALLGILAHASGIATAAARCKEAAG-DKPVLSFGARHvhpAIAP--- 144

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 180 lTASTYSYLGGFDSSSNVLAGQLRGVPVAGTLAHSFVTSFsGSEVppdpmlapaagegpgvdLAAKAqvWLEQVcahlgl 259
Cdd:PRK08662 145 -MMDRAAYIGGCDGVSGVLGAELLGIEPSGTMPHALILIF-GDQV-----------------EAWKA--FDEVV------ 197

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 260 gvqephPGEraafvayalaFPRAFqgLLDTYSVWRSglpNFLAVALALGElgyRAVGVRLDS-----GDLLQQAQEIRKV 334
Cdd:PRK08662 198 ------PPD----------VPRIA--LVDTFKDERE---EALRAAEALGD---RLDGVRLDTpssrrGNFRKIVREVRWT 253

                        250       260       270       280
                 ....*....|....*....|....*....|....*....|....*...
gi 558472750 335 FRAAAaqfqvpwLESVLIVVSNNIDEEALARLAQegsEVNVIGIGTSV 382
Cdd:PRK08662 254 LDIRG-------YEHVKIFVSGGLDPERIRELRD---VVDGFGVGTYI 291
PncB_like cd01401
Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate ...
 14-416 1.46e-11

Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting, reaction in the NAD salvage synthesis. This salvage pathway serves to recycle NAD degradation products. This subgroup is present in bacteria, archea and funghi.


Pssm-ID: 238695 [Multi-domain]  Cd Length: 377  Bit Score: 66.12  E-value: 1.46e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  14 RPLL-TDLYQATMALGYWRA-GRARDAAEF-----ELFFRRcpfggafaLAAGLRDCVRFLRAFRLRDADVQFLASVLPP 86
Cdd:cd01401    1 RSLLdTDLYKLTMQQAVLHHyPDVQVTYEFtnrspEDFLEE--------AAEALREQIDHLANLRFSEEELAYLRRSLPF 72

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  87 DTdPAFFEHLRA--LDCSEVTVRA-LPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS--YASLVATNA--------- 152
Cdd:cd01401   73 LK-PDYLDYLELfrLNPEEVVVRLdTGKGQLD------IRISGPWKDTILYEVPLLAIVSevYFRFRDADWdyeeqlekl 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 153 --------ARLRLIAGPEKRLLEMGLRRAQGPD------GGLTASTYSYLGGfdsSSNVLAGQLRGVPVAGTLAHSFVTS 218
Cdd:cd01401  146 eeklerllEEAKRRDLNGFRFSDFGTRRRFSYEvqetvlKGLKQAAPGYLTG---TSNVHFAMKYGLTPIGTVAHEWFMA 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 219 FSGsevppdpmLAPAAGEGPGVDLaakaQVWLEQVCAHLGLgvqephpgeraafvayalafprafqGLLDTYsvwrsGLP 298
Cdd:cd01401  223 HQA--------LTGDLKDSQKAAL----ERWVREYGGDLGI-------------------------ALTDTF-----GTD 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 299 NFLAVALAlgELGYRAVGVRLDSGDLLQQAQEIRKvfraaaaqfqvpWLESV-------LIVVSNNIDEEA---LARLAQ 368
Cdd:cd01401  261 AFLRDFDL--YFAKLFDGVRHDSGDPFEWGEKAIA------------HYEKLgidpktkTLVFSDGLDVEKaleLYEYFK 326

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|...
gi 558472750 369 EGseVNVI-GIGTS----VVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQT 416
Cdd:cd01401  327 GR--IKVSfGIGTNltndFGNKEKSTPLNIVIKLVECNGRPVAKISDSPGKNM 377
PRK05321 PRK05321
nicotinate phosphoribosyltransferase; Provisional
 14-416 1.56e-11

nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 235406 [Multi-domain]  Cd Length: 400  Bit Score: 65.94  E-value: 1.56e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  14 RPLL-TDLYQATMALGYWRagRARDA-AEFELffrRCPFGGAFA--LAAGLRDCVRFLRAFRLRDADVQFLAS--VLPPD 87
Cdd:PRK05321  10 RSLLdTDFYKLTMQQAVLH--HYPDAqVEYEF---ICRNDEVDLaeYIDEIREQLDHLCTLRLTDDELDYLRGlpFFKPD 84

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750  88 tdpaFFEHLRA--LDCSEVTVRAlPEGSLAfpgvplLQVSGPLLVVQLLETPLLCLVS-----YASLVATNA---ARL-- 155
Cdd:PRK05321  85 ----FLDWLRLfrLNPYEVTVSI-DDGQLD------IRIEGPWLETILWEVPLLAIISelyfrARSPEVLYAqakRRLwe 153

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 156 ---RLIAGPEK---RLLEMGLRRaqgpdggltasTYSYL--------------GGFDSSSNVLAGQLRGVPVAGTLAHsf 215
Cdd:PRK05321 154 kieLLKALPDLsgfKIADFGTRR-----------RFSFEwqeevvealkeglpGAFVGTSNVHLAMKLGLTPIGTMAH-- 220

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 216 vtsfsgsEvppdpmlapaagegpgvdlaakaqvWLeQVCAHLGLGVQEphpGERAAFVAYAlafpRAFQGLL-----DTY 290
Cdd:PRK05321 221 -------E-------------------------WF-MAHQALGPRLRD---SQYAALEDWV----REYRGDLgialtDTI 260

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 558472750 291 svwrsGLPNFLA-VALALGELgYraVGVRLDSGDLLQQAQEIrkvfraaaaqfqVPWLESV-------LIVVSNNID-EE 361
Cdd:PRK05321 261 -----GMDAFLRdFDLYFAKL-F--DGLRHDSGDPIEWGEKA------------IAHYEKLgidprtkTLVFSDGLDfDK 320

                        410       420       430       440       450
                 ....*....|....*....|....*....|....*....|....*....|....*...
gi 558472750 362 ALARLAQEGSEVNVI-GIGTSvVTC--PQQPSLGGVYKLVAVGGQPRMKLTEDPEKQT 416
Cdd:PRK05321 321 ALELYRHFKGRIKLSfGIGTN-LTNdfPGVKPLNIVIKLVECNGRPVAKLSDSPGKTM 377
PRK09198 PRK09198
putative nicotinate phosphoribosyltransferase; Provisional
 104-158 3.39e-04

putative nicotinate phosphoribosyltransferase; Provisional


Pssm-ID: 236407 [Multi-domain]  Cd Length: 463  Bit Score: 43.34  E-value: 3.39e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 558472750 104 VTVRALPEGSLAFPGVPLLQVSG--PLL--VVQLLETPLLCLVSYASLVATNAARLRLI 158
Cdd:PRK09198  98 LRIKAVPEGSVVPVHNVLMTIENtdPEFfwLPNYLETLLLRNVWYPSTVATISWEYKQL 156
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH