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Conserved domains on  [gi|557786096|ref|NP_001273568|]
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vacuolar fusion protein MON1 homolog B isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 300-407 7.96e-33

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465955  Cd Length: 103  Bit Score: 119.67  E-value: 7.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  300 GLRHFLYKpldipdhHRQLPQFTSPELE--APYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKF 377
Cdd:pfam19038   1 GLLHFLYK-------SRSTVQFTAPSLPtdPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCF 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 557786096  378 ELYTCLSPLVTKAGAILVVTKLLRWVKKEE 407
Cdd:pfam19038  74 ELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 48-123 1.90e-23

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465953  Cd Length: 125  Bit Score: 94.97  E-value: 1.90e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557786096   48 ETEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRL 123
Cdd:pfam19036  50 TCENTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 163-261 2.91e-14

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


:

Pssm-ID: 465954  Cd Length: 98  Bit Score: 68.41  E-value: 2.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  163 GLALSVLAVGGRLITAAQERNVlaecRLDPADLQLLLDWVGA-PAFAAGEAWAPVCLPRFNPdGFFYAYVARLDAMPVCL 241
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWA----SLHPSDLLLLFLLVQSsSPFKSLELWIPICLPKFNP-GVLHRYISFLGDINLCL 76

                          90       100
                  ....*....|....*....|
gi 557786096  242 LLLGTQREAFHAMAACRRLV 261
Cdd:pfam19037  77 LLLSGDKPAFFELSLLDDRF 96
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 300-407 7.96e-33

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 119.67  E-value: 7.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  300 GLRHFLYKpldipdhHRQLPQFTSPELE--APYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKF 377
Cdd:pfam19038   1 GLLHFLYK-------SRSTVQFTAPSLPtdPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCF 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 557786096  378 ELYTCLSPLVTKAGAILVVTKLLRWVKKEE 407
Cdd:pfam19038  74 ELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 48-123 1.90e-23

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 94.97  E-value: 1.90e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557786096   48 ETEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRL 123
Cdd:pfam19036  50 TCENTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 163-261 2.91e-14

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 68.41  E-value: 2.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  163 GLALSVLAVGGRLITAAQERNVlaecRLDPADLQLLLDWVGA-PAFAAGEAWAPVCLPRFNPdGFFYAYVARLDAMPVCL 241
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWA----SLHPSDLLLLFLLVQSsSPFKSLELWIPICLPKFNP-GVLHRYISFLGDINLCL 76

                          90       100
                  ....*....|....*....|
gi 557786096  242 LLLGTQREAFHAMAACRRLV 261
Cdd:pfam19037  77 LLLSGDKPAFFELSLLDDRF 96
 
Name Accession Description Interval E-value
Fuz_longin_3 pfam19038
Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in ...
 300-407 7.96e-33

Third Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the third Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465955  Cd Length: 103  Bit Score: 119.67  E-value: 7.96e-33
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  300 GLRHFLYKpldipdhHRQLPQFTSPELE--APYSREEERQRLSDLYHRLHARLHSTSRPLRLIYHVAEKETLLAWVTSKF 377
Cdd:pfam19038   1 GLLHFLYK-------SRSTVQFTAPSLPtdPPYTTEQRRRRLRSFYQLLHSTLHSPSGPLKLLYKVSDYESLLAWFTDCF 73

                          90       100       110
                  ....*....|....*....|....*....|
gi 557786096  378 ELYTCLSPLVTKAGAILVVTKLLRWVKKEE 407
Cdd:pfam19038  74 ELYVLFSPLVPKHALRSSANKLLKWIKKEE 103
Fuz_longin_1 pfam19036
First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain ...
 48-123 1.90e-23

First Longin domain of FUZ, MON1 and HPS1; This entry is specific to the first Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465953  Cd Length: 125  Bit Score: 94.97  E-value: 1.90e-23
                          10        20        30        40        50        60        70
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557786096   48 ETEDHKLVFLQQGPLLLVAMSRTSQSAAQLRGELLAVHAQIVSTLTRASVARIFAHKQNYDLRRLLAGSERTLDRL 123
Cdd:pfam19036  50 TCENTKVVFLEKGPLLLVAISRSGESEQQLRRQLDVVYNQILSLLGLPQLTRIFNRRPNEDLRRLLSGLEDLLDSL 125
Fuz_longin_2 pfam19037
Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found ...
 163-261 2.91e-14

Second Longin domain of FUZ, MON1 and HPS1; This entry represents a longin-like domain found in Fuz and related proteins. This entry is specific to the second Longin domain of the HerMon (Hermansky-Pudlak syndrome and MON1-CCZ1) family, including protein sequences of FUZ, MON1 and HPS1 families. The Mon1/Ccz1 complex (MC1) is the GDP/GTP exchange factor (GEF) for the Rab GTPase Ypt7/Rab7 during vesicular trafficking. The Hps1/Hps4 complex (BLOC-3) is a Rab32 and Rab38 GEF and is required for biogenesis of melanosomes and platelet dense granules. Inturned (INTU) and Fuzzy (FUZ) proteins interact as members of the ciliogenesis and planar polarity effector (CPLANE) complex that controls recruitment of intraflagellar transport machinery to the basal body of primary cilia.


Pssm-ID: 465954  Cd Length: 98  Bit Score: 68.41  E-value: 2.91e-14
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557786096  163 GLALSVLAVGGRLITAAQERNVlaecRLDPADLQLLLDWVGA-PAFAAGEAWAPVCLPRFNPdGFFYAYVARLDAMPVCL 241
Cdd:pfam19037   2 SLLFALLLVGGKLVAAYRPRWA----SLHPSDLLLLFLLVQSsSPFKSLELWIPICLPKFNP-GVLHRYISFLGDINLCL 76

                          90       100
                  ....*....|....*....|
gi 557786096  242 LLLGTQREAFHAMAACRRLV 261
Cdd:pfam19037  77 LLLSGDKPAFFELSLLDDRF 96
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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