|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
37-256 |
5.66e-110 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 340.72 E-value: 5.66e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKRNGRCMVADEMGLGKTIQAIGITYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPELSPEEINVIQNK 116
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 117 TDVRRMSTSKVTVLGYGLLTADAKTLIdalnNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARRAILLTGTPALGRPE 196
Cdd:cd18010 81 KDGLRDGDAKVVIVSYDLLRRLEKQLL----ARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 197 ELFMQIEALFPQKFGRWTDYAKRYCNAHiryFGKRPQWDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18010 157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
29-464 |
1.57e-90 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 304.84 E-value: 1.57e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 29 LPDRLRAKLLPFQKDGIIFAL---KRNGRCMVADEMGLGKTIQAIGITYFYKEE---WPLLIVVPSSLRYPWTEEIEKWI 102
Cdd:COG0553 234 LPAGLKATLRPYQLEGAAWLLflrRLGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 103 PELSPEEINVIQN-KTDVRRMSTSKVTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKAR 181
Cdd:COG0553 314 PGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRD----IELLAAVDWDLVILDEAQHIKNPATKRAKAVRAL--KAR 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 182 RAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRYfgkrpqwdcrGASNLNELHQLLSDIMIRRLKTEV 261
Cdd:COG0553 388 HRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRRTKEDV 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 262 LTQLPPKVRQRIPFDLPSAAAK---ELNTSFEEWekIMRTPNSGAMETVMGLITRMfKQTAI----------------AK 322
Cdd:COG0553 458 LKDLPEKTEETLYVELTPEQRAlyeAVLEYLRRE--LEGAEGIRRRGLILAALTRL-RQICShpallleegaelsgrsAK 534
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 323 AGAVKDYIKMMLQNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAAGQ 402
Cdd:COG0553 535 LEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGE 613
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557440797 403 GLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNRKAQ 464
Cdd:COG0553 614 GLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
321-446 |
5.39e-45 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 158.41 E-value: 5.39e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 321 AKAGAVKDYIKMMLQNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAA 400
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 557440797 401 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 446
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
41-301 |
4.48e-32 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 127.03 E-value: 4.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 41 QKDGIIFALKR-NGR---CMVADEMGLGKTIQAIG-ITYFYKEE----WPLLIVVPSSLRYPWTEEIEKWipeLSPEEIN 111
Cdd:pfam00176 2 QIEGVNWMLSLeNNLgrgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 112 V--IQNKTDVRRMSTSKVTVLG-YGLLTADAKTLI---DALNNQNFKVVIVDESHYMKSrnaTRSRILLPIVQ-KARRAI 184
Cdd:pfam00176 79 VvvLHGNKRPQERWKNDPNFLAdFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKN---SKSKLSKALKSlKTRNRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 185 LLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYcnahiryfgKRPQWDCRGASNLNELHQLLSDIMIRRLKTEVLTQ 264
Cdd:pfam00176 156 ILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWF---------DRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKS 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 557440797 265 LPPKVRQ--RIPFD----------LPSAAAKELNTSFEEWEKIMRTPNS 301
Cdd:pfam00176 227 LPPKVEYilFCRLSklqrklyqtfLLKKDLNAIKTGEGGREIKASLLNI 275
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
52-442 |
9.04e-22 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 102.19 E-value: 9.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIGITYFYKE----EWPLLIVVPSSLRYPWTEEIEKWIPEL-------SPEEINVIQNKTDVR 120
Cdd:PLN03142 190 NG--ILADEMGLGKTLQTISLLGYLHEyrgiTGPHMVVAPKSTLGNWMNEIRRFCPVLravkfhgNPEERAHQREELLVA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 121 rmSTSKVTVLGYGLLTADaKTlidALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARraILLTGTPALGRPEELFM 200
Cdd:PLN03142 268 --GKFDVCVTSFEMAIKE-KT---ALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 201 QIEALFPQKFGrwtdyakrycNAhiryfGKRPQWDCRGASN-----LNELHQLLSDIMIRRLKTEVLTQLPPKVRQRIPF 275
Cdd:PLN03142 340 LLNFLLPEIFS----------SA-----ETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKV 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 276 DLpSAAAKELNTSFeeWEKIMRTPNSGA-----METVMGLIT-----RMFKQtaiAKAGA--------VKDYIKMML--- 334
Cdd:PLN03142 405 GM-SQMQKQYYKAL--LQKDLDVVNAGGerkrlLNIAMQLRKccnhpYLFQG---AEPGPpyttgehlVENSGKMVLldk 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 335 ------QNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFT 407
Cdd:PLN03142 479 llpklkERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLA 557
|
410 420 430
....*....|....*....|....*....|....*
gi 557440797 408 AASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 442
Cdd:PLN03142 558 TADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
29-216 |
1.82e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 90.63 E-value: 1.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 29 LPDRLRAKLLPFQKDGIIFALKRNGRCMVADEMGLGKTIQAI--GITYFYKEEWPL-LIVVP-SSLRYPWTEEIEKWIPE 104
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALlpALEALKRGKGGRvLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 105 LSPEEINVI--QNKTDVRRMSTSK---VTVLGYGLLTADAKTliDALNNQNFKVVIVDESHYMKSRNATRS-RILLPIVQ 178
Cdd:smart00487 81 LGLKVVGLYggDSKREQLRKLESGktdILVTTPGRLLDLLEN--DKLSLSNVDLVILDEAHRLLDGGFGDQlEKLLKLLP 158
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 557440797 179 KARRAILLTGTPALGRPE--ELFMQIEALFPQKFGRWTDY 216
Cdd:smart00487 159 KNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTPLEPI 198
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
330-435 |
1.19e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.09 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 330 IKMMLQNDSLKFLVFAHHLSMLQaCTEAVIENKTRYIRIDGSVSSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 409
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 557440797 410 SHVVFAELYWDPGHIKQAEDRAHRIG 435
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
360-435 |
3.51e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 65.70 E-value: 3.51e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557440797 360 ENKTRYIRIDGSVSSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 435
Cdd:smart00490 9 ELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
1009-1047 |
1.02e-07 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 49.39 E-value: 1.02e-07
10 20 30
....*....|....*....|....*....|....*....
gi 557440797 1009 PGEGHFWQVDHIKPVYGGGgQCSLDNLQTLCTVCHKERT 1047
Cdd:cd00085 20 PGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
|
|
| DpdE |
NF041062 |
protein DpdE; |
54-215 |
1.11e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 56.13 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 54 RCMVADEMGLGKTIQAiGI----TYFYKEEWPLLIVVPSSLRypwteeiEKWIPELSpeeinviqNKTDVRRMSTSKVTV 129
Cdd:NF041062 172 RYLLADEVGLGKTIEA-GLvirqHLLDNPDARVLVLVPDALV-------RQWRRELR--------DKFFLDDFPGARVRV 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 130 LGYG-LLTADAKTlidalnnQNFKVVIVDESHYM-------KSRNATRSRILLPIVQKARRAILLTGTPALGRPEELFMQ 201
Cdd:NF041062 236 LSHEePERWEPLL-------DAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEETFLAL 308
|
170
....*....|....
gi 557440797 202 IEALFPQKFgRWTD 215
Cdd:NF041062 309 LHLLDPDLY-PLDD 321
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
1014-1049 |
3.19e-05 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 42.34 E-value: 3.19e-05
10 20 30
....*....|....*....|....*....|....*.
gi 557440797 1014 FWQVDHIKPVYGGGGQcSLDNLQTLCTVCHKERTAR 1049
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
1009-1044 |
4.60e-05 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 42.28 E-value: 4.60e-05
10 20 30
....*....|....*....|....*....|....*.
gi 557440797 1009 PGEGHFWQVDHIKPVYGGGGQcSLDNLQTLCTVCHK 1044
Cdd:COG1403 28 PFSGDALEVDHIIPRSRGGTD-TWENLVLLCRRCNR 62
|
|
| zf-RanBP |
pfam00641 |
Zn-finger in Ran binding protein and others; |
625-647 |
7.72e-05 |
|
Zn-finger in Ran binding protein and others;
Pssm-ID: 395516 [Multi-domain] Cd Length: 30 Bit Score: 40.80 E-value: 7.72e-05
|
| HNHc |
smart00507 |
HNH nucleases; |
1015-1043 |
2.86e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 39.75 E-value: 2.86e-04
10 20
....*....|....*....|....*....
gi 557440797 1015 WQVDHIKPvYGGGGQCSLDNLQTLCTVCH 1043
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
625-647 |
1.28e-03 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.30 E-value: 1.28e-03
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| DEXHc_HARP_SMARCAL1 |
cd18010 |
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin ... |
37-256 |
5.66e-110 |
|
DEXH-box helicase domain of SMARCAL1; SMARCAL1 (SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1, also known as HARP) is recruited to stalled replication forks to promote repair and helps restart replication. It plays a role in DNA repair, telomere maintenance and replication fork stability in response to DNA replication stress. Mutations cause Schimke Immunoosseous Dysplasia. SMARCAL1 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350768 [Multi-domain] Cd Length: 213 Bit Score: 340.72 E-value: 5.66e-110
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKRNGRCMVADEMGLGKTIQAIGITYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPELSPEEINVIQNK 116
Cdd:cd18010 1 LLPFQREGVCFALRRGGRVLIADEMGLGKTVQAIAIAAYYREEWPLLIVCPSSLRLTWADEIERWLPSLPPDDIQVIVKS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 117 TDVRRMSTSKVTVLGYGLLTADAKTLIdalnNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARRAILLTGTPALGRPE 196
Cdd:cd18010 81 KDGLRDGDAKVVIVSYDLLRRLEKQLL----ARKFKVVICDESHYLKNSKAKRTKAALPLLKRAKRVILLSGTPALSRPI 156
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 197 ELFMQIEALFPQKFGRWTDYAKRYCNAHiryFGKRPQWDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18010 157 ELFTQLDALDPKLFGRFHDFGRRYCAAK---QGGFGWDYSGSSNLEELHLLLLATIMIRR 213
|
|
| HepA |
COG0553 |
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, ... |
29-464 |
1.57e-90 |
|
Superfamily II DNA or RNA helicase, SNF2 family [Transcription, Replication, recombination, and repair];
Pssm-ID: 440319 [Multi-domain] Cd Length: 682 Bit Score: 304.84 E-value: 1.57e-90
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 29 LPDRLRAKLLPFQKDGIIFAL---KRNGRCMVADEMGLGKTIQAIGITYFYKEE---WPLLIVVPSSLRYPWTEEIEKWI 102
Cdd:COG0553 234 LPAGLKATLRPYQLEGAAWLLflrRLGLGGLLADDMGLGKTIQALALLLELKERglaRPVLIVAPTSLVGNWQRELAKFA 313
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 103 PELSPEEINVIQN-KTDVRRMSTSKVTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKAR 181
Cdd:COG0553 314 PGLRVLVLDGTRErAKGANPFEDADLVITSYGLLRRD----IELLAAVDWDLVILDEAQHIKNPATKRAKAVRAL--KAR 387
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 182 RAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRYfgkrpqwdcrGASNLNELHQLLSDIMIRRLKTEV 261
Cdd:COG0553 388 HRLALTGTPVENRLEELWSLLDFLNPGLLGSLKAFRERFARPIEKG----------DEEALERLRRLLRPFLLRRTKEDV 457
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 262 LTQLPPKVRQRIPFDLPSAAAK---ELNTSFEEWekIMRTPNSGAMETVMGLITRMfKQTAI----------------AK 322
Cdd:COG0553 458 LKDLPEKTEETLYVELTPEQRAlyeAVLEYLRRE--LEGAEGIRRRGLILAALTRL-RQICShpallleegaelsgrsAK 534
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 323 AGAVKDYIKMMLQNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAAGQ 402
Cdd:COG0553 535 LEALLELLEELLAEGE-KVLVFSQFTDTLDLLEERLEERGIEYAYLHGGTSAEERDELVDRFQEGPEAPVFLISLKAGGE 613
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557440797 403 GLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLIANGTLDTLMWGMLNRKAQ 464
Cdd:COG0553 614 GLNLTAADHVIHYDLWWNPAVEEQAIDRAHRIGQTRDVQVYKLVAEGTIEEKILELLEEKRA 675
|
|
| SF2_C_SNF |
cd18793 |
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) ... |
321-446 |
5.39e-45 |
|
C-terminal helicase domain of the SNF family helicases; The Sucrose Non-Fermenting (SNF) family includes chromatin-remodeling factors, such as CHD proteins and SMARCA proteins, recombination proteins Rad54, and many others. They are DEAD-like helicases belonging to superfamily (SF)2, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. Similar to SF1 helicases, SF2 helicases do not form toroidal structures like SF3-6 helicases. Their helicase core consists of two similar protein domains that resemble the fold of the recombination protein RecA. This model describes the C-terminal domain, also called HelicC.
Pssm-ID: 350180 [Multi-domain] Cd Length: 135 Bit Score: 158.41 E-value: 5.39e-45
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 321 AKAGAVKDYIKMMLQNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTRVAILSIQAA 400
Cdd:cd18793 11 GKLEALLELLEELREPGE-KVLIFSQFTDTLDILEEALRERGIKYLRLDGSTSSKERQKLVDRFNEDPDIRVFLLSTKAG 89
|
90 100 110 120
....*....|....*....|....*....|....*....|....*.
gi 557440797 401 GQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNIHYLI 446
Cdd:cd18793 90 GVGLNLTAANRVILYDPWWNPAVEEQAIDRAHRIGQKKPVVVYRLI 135
|
|
| DEXHc_Snf |
cd17919 |
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting ... |
37-208 |
6.55e-37 |
|
DEXH/Q-box helicase domain of DEAD-like helicase Snf family proteins; Sucrose Non-Fermenting (SNF) proteins DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350677 [Multi-domain] Cd Length: 182 Bit Score: 137.31 E-value: 6.55e-37
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFAL---KRNGRCMVADEMGLGKTIQAIGITYFYKEE----WPLLIVVPSSLRYPWTEEIEKWIPEL---- 105
Cdd:cd17919 1 LRPYQLEGLNFLLelyENGPGGILADEMGLGKTLQAIAFLAYLLKEgkerGPVLVVCPLSVLENWEREFEKWTPDLrvvv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 106 ---SPEEINVIQNKTDVRrmsTSKVTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARR 182
Cdd:cd17919 81 yhgSQRERAQIRAKEKLD---KFDVVLTTYETLRRD----KASLRKFRWDLVVVDEAHRLKNPKSQLSKALKAL--RAKR 151
|
170 180
....*....|....*....|....*.
gi 557440797 183 AILLTGTPALGRPEELFMQIEALFPQ 208
Cdd:cd17919 152 RLLLTGTPLQNNLEELWALLDFLDPP 177
|
|
| SNF2-rel_dom |
pfam00176 |
SNF2-related domain; This domain is found in proteins involved in a variety of processes ... |
41-301 |
4.48e-32 |
|
SNF2-related domain; This domain is found in proteins involved in a variety of processes including transcription regulation (e.g., SNF2, STH1, brahma, MOT1), DNA repair (e.g., ERCC6, RAD16, RAD5), DNA recombination (e.g., RAD54), and chromatin unwinding (e.g., ISWI) as well as a variety of other proteins with little functional information (e.g., lodestar, ETL1). SNF2 functions as the ATPase component of the SNF2/SWI multisubunit complex, which utilizes energy derived from ATP hydrolysis to disrupt histone-DNA interactions, resulting in the increased accessibility of DNA to transcription factors.
Pssm-ID: 425504 [Multi-domain] Cd Length: 289 Bit Score: 127.03 E-value: 4.48e-32
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 41 QKDGIIFALKR-NGR---CMVADEMGLGKTIQAIG-ITYFYKEE----WPLLIVVPSSLRYPWTEEIEKWipeLSPEEIN 111
Cdd:pfam00176 2 QIEGVNWMLSLeNNLgrgGILADEMGLGKTLQTISlLLYLKHVDknwgGPTLIVVPLSLLHNWMNEFERW---VSPPALR 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 112 V--IQNKTDVRRMSTSKVTVLG-YGLLTADAKTLI---DALNNQNFKVVIVDESHYMKSrnaTRSRILLPIVQ-KARRAI 184
Cdd:pfam00176 79 VvvLHGNKRPQERWKNDPNFLAdFDVVITTYETLRkhkELLKKVHWHRIVLDEGHRLKN---SKSKLSKALKSlKTRNRW 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 185 LLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYcnahiryfgKRPQWDCRGASNLNELHQLLSDIMIRRLKTEVLTQ 264
Cdd:pfam00176 156 ILTGTPLQNNLEELWALLNFLRPGPFGSLSTFRNWF---------DRPIERGGGKKGVSRLHKLLKPFLLRRTKKDVEKS 226
|
250 260 270 280
....*....|....*....|....*....|....*....|....*....
gi 557440797 265 LPPKVRQ--RIPFD----------LPSAAAKELNTSFEEWEKIMRTPNS 301
Cdd:pfam00176 227 LPPKVEYilFCRLSklqrklyqtfLLKKDLNAIKTGEGGREIKASLLNI 275
|
|
| DEXQc_arch_SWI2_SNF2 |
cd18012 |
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging ... |
33-258 |
1.26e-29 |
|
DEAQ-box helicase domain of archaeal and bacterial SNF2-related proteins; Proteins belonging to SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprises a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. Archaeal SWI2 and SNF2 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350770 [Multi-domain] Cd Length: 218 Bit Score: 117.67 E-value: 1.26e-29
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 33 LRAKLLPFQKDGI--IFALKRNG-RCMVADEMGLGKTIQAIG-ITYFYKEEW--PLLIVVPSSLRYPWTEEIEKWIPELs 106
Cdd:cd18012 1 LKATLRPYQKEGFnwLSFLRHYGlGGILADDMGLGKTLQTLAlLLSRKEEGRkgPSLVVAPTSLIYNWEEEAAKFAPEL- 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 107 peeiNVIQNKTDVRRMSTSK------VTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKA 180
Cdd:cd18012 80 ----KVLVIHGTKRKREKLRaledydLVITSYGLLRRD----IELLKEVKFHYLVLDEAQNIKNPQTKTAKAVKAL--KA 149
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557440797 181 RRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYcnahiryfgKRPQWDCRGASNLNELHQLLSDIMIRRLK 258
Cdd:cd18012 150 DHRLALTGTPIENHLGELWSIFDFLNPGLLGSYKRFKKRF---------AKPIEKDGDEEALEELKKLISPFILRRLK 218
|
|
| DEXDc_RapA |
cd18011 |
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated ... |
37-213 |
1.45e-27 |
|
DEXH-box helicase domain of RapA; In bacteria, RapA is an RNA polymerase (RNAP)-associated SWI2/SNF2 (switch/sucrose non-fermentable) protein that mediates RNAP recycling during transcription. The ATPase activity of RapA is stimulated by its interaction with RNAP and inhibited by its N-terminal domain. The conformational changes of RapA and its interaction with RNAP are essential for RNAP recycling. RapA is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350769 [Multi-domain] Cd Length: 207 Bit Score: 111.23 E-value: 1.45e-27
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFAL-KRNGRCMVADEMGLGKTIQAIGItyfYKEEW------PLLIVVPSSLRYPWTEEIEK--WIPELSP 107
Cdd:cd18011 1 PLPHQIDAVLRALrKPPVRLLLADEVGLGKTIEAGLI---IKELLlrgdakRVLILCPASLVEQWQDELQDkfGLPFLIL 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 108 EEINVIQNKTDVRRMSTS-KVTVLGYGLLTADAKtLIDALNNQNFKVVIVDESHYMKSRNAT----RSRILLPIVQKARR 182
Cdd:cd18011 78 DRETAAQLRRLIGNPFEEfPIVIVSLDLLKRSEE-RRGLLLSEEWDLVVVDEAHKLRNSGGGketkRYKLGRLLAKRARH 156
|
170 180 190
....*....|....*....|....*....|.
gi 557440797 183 AILLTGTPALGRPEELFMQIEALFPQKFGRW 213
Cdd:cd18011 157 VLLLTATPHNGKEEDFRALLSLLDPGRFAVL 187
|
|
| DEXHc_CHD6_7_8_9 |
cd17995 |
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; ... |
37-256 |
5.70e-24 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding protein 6, 7, 8 and 9; Chromodomain-helicase-DNA-binding protein 6-9 (CHD6, CHD7, CHD8, and CHD9) are members of the DEAD-like helicases superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350753 [Multi-domain] Cd Length: 223 Bit Score: 101.56 E-value: 5.70e-24
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDG---IIFALKRNGRCMVADEMGLGKTIQAIG-ITYFYKEEW---PLLIVVPSSLRYPWTEEIEKWIP------ 103
Cdd:cd17995 1 LRDYQLEGvnwLLFNWYNRRNCILADEMGLGKTIQSIAfLEHLYQVEGirgPFLVIAPLSTIPNWQREFETWTDmnvvvy 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 104 ---ELSPEEINVIQ--NKTDVRRMSTS--KVTVL--GYGLLTADAktliDALNNQNFKVVIVDESHYMKSRNATRSRILL 174
Cdd:cd17995 81 hgsGESRQIIQQYEmyFKDAQGRKKKGvyKFDVLitTYEMVIADA----EELRKIPWRVVVVDEAHRLKNRNSKLLQGLK 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 175 PIVQKARraILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCnahiryfgkrpqwDCRGASNLNELHQLLSDIMI 254
Cdd:cd17995 157 KLTLEHK--LLLTGTPLQNNTEELWSLLNFLEPEKFPSSEEFLEEFG-------------DLKTAEQVEKLQALLKPYML 221
|
..
gi 557440797 255 RR 256
Cdd:cd17995 222 RR 223
|
|
| DEXHc_SMARCA2_SMARCA4 |
cd17996 |
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin ... |
52-258 |
2.85e-22 |
|
DEXH-box helicase domain of SMARCA2 and SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, members 2 and 4 (SMARCA2 and SMARCA4) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350754 [Multi-domain] Cd Length: 233 Bit Score: 96.67 E-value: 2.85e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIG-ITYFY---KEEWPLLIVVPSSLRYPWTEEIEKWIPELSpeeINVIQNKTDVRRMSTSKV 127
Cdd:cd17996 24 NG--ILADEMGLGKTIQTISlITYLMekkKNNGPYLVIVPLSTLSNWVSEFEKWAPSVS---KIVYKGTPDVRKKLQSQI 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 128 TVLGYG-LLTADAKTLID--ALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQkARRAILLTGTPALGRPEELFMQIEA 204
Cdd:cd17996 99 RAGKFNvLLTTYEYIIKDkpLLSKIKWKYMIIDEGHRMKNAQSKLTQTLNTYYH-ARYRLLLTGTPLQNNLPELWALLNF 177
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*..
gi 557440797 205 LFPQKFGRWTDYAKRYcNAHIRYFGKRPQWDCRGASNL---NELHQLLSDIMIRRLK 258
Cdd:cd17996 178 LLPKIFKSCKTFEQWF-NTPFANTGEQVKIELNEEETLliiRRLHKVLRPFLLRRLK 233
|
|
| DEXDc_SHPRH-like |
cd18008 |
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the ... |
37-256 |
3.75e-22 |
|
DEXH-box helicase domain of SHPRH-like proteins; The SHPRH-like subgroup belongs to the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350766 [Multi-domain] Cd Length: 241 Bit Score: 96.59 E-value: 3.75e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKRNGrcMVADEMGLGKTIQAI-------------GITYFYKEEWPL--------LIVVPSSLRYPWT 95
Cdd:cd18008 1 LLPYQKQGLAWMLPRGG--ILADEMGLGKTIQALalilatrpqdpkiPEELEENSSDPKklylskttLIVVPLSLLSQWK 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 96 EEIEKWIPELSPeeiNVI-----QNKTDVRRMSTSKVTVLGYGLLTADAKTLIDALNNQN------------FKVVIVDE 158
Cdd:cd18008 79 DEIEKHTKPGSL---KVYvyhgsKRIKSIEELSDYDIVITTYGTLASEFPKNKKGGGRDSkekeasplhrirWYRVILDE 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 159 SHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRPEELFMQIealfpqKFGRWTDYAKRYC-NAHIryfgkRPQWDCR 237
Cdd:cd18008 156 AHNIKNRSTKTSRAVCAL--KAERRWCLTGTPIQNSLDDLYSLL------RFLRVEPFGDYPWfNSDI-----SKPFSKN 222
|
250
....*....|....*....
gi 557440797 238 GASNLNELHQLLSDIMIRR 256
Cdd:cd18008 223 DRKALERLQALLKPILLRR 241
|
|
| DEXHc_SMARCAD1 |
cd17998 |
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent ... |
37-210 |
3.76e-22 |
|
DEXH-box helicase domain of SMARCAD1; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1, also known as ATP-dependent helicase 1 or Hel1) possesses intrinsic ATP-dependent nucleosome-remodeling activity and is required for both DNA repair and heterochromatin organization. SMARCAD1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350756 [Multi-domain] Cd Length: 187 Bit Score: 95.14 E-value: 3.76e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITYFYKEE---WPLLIVVPSSLRYPWTEEIEKWIPEL----- 105
Cdd:cd17998 1 LKDYQLIGLnwlNLLYQKKLSGILADEMGLGKTIQVIAFLAYLKEIgipGPHLVVVPSSTLDNWLREFKRWCPSLkvepy 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 106 --SPEE-----INVIQNKTDVrrmstsKVTVLGYGLLT--ADAKTLidaLNNQNFKVVIVDESHYMKSRNATRSRILLPI 176
Cdd:cd17998 81 ygSQEErkhlrYDILKGLEDF------DVIVTTYNLATsnPDDRSF---FKRLKLNYVVYDEGHMLKNMTSERYRHLMTI 151
|
170 180 190
....*....|....*....|....*....|....
gi 557440797 177 vqKARRAILLTGTPALGRPEELFMQIEALFPQKF 210
Cdd:cd17998 152 --NANFRLLLTGTPLQNNLLELMSLLNFIMPKPF 183
|
|
| PLN03142 |
PLN03142 |
Probable chromatin-remodeling complex ATPase chain; Provisional |
52-442 |
9.04e-22 |
|
Probable chromatin-remodeling complex ATPase chain; Provisional
Pssm-ID: 215601 [Multi-domain] Cd Length: 1033 Bit Score: 102.19 E-value: 9.04e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIGITYFYKE----EWPLLIVVPSSLRYPWTEEIEKWIPEL-------SPEEINVIQNKTDVR 120
Cdd:PLN03142 190 NG--ILADEMGLGKTLQTISLLGYLHEyrgiTGPHMVVAPKSTLGNWMNEIRRFCPVLravkfhgNPEERAHQREELLVA 267
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 121 rmSTSKVTVLGYGLLTADaKTlidALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARraILLTGTPALGRPEELFM 200
Cdd:PLN03142 268 --GKFDVCVTSFEMAIKE-KT---ALKRFSWRYIIIDEAHRIKNENSLLSKTMRLFSTNYR--LLITGTPLQNNLHELWA 339
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 201 QIEALFPQKFGrwtdyakrycNAhiryfGKRPQWDCRGASN-----LNELHQLLSDIMIRRLKTEVLTQLPPKVRQRIPF 275
Cdd:PLN03142 340 LLNFLLPEIFS----------SA-----ETFDEWFQISGENdqqevVQQLHKVLRPFLLRRLKSDVEKGLPPKKETILKV 404
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 276 DLpSAAAKELNTSFeeWEKIMRTPNSGA-----METVMGLIT-----RMFKQtaiAKAGA--------VKDYIKMML--- 334
Cdd:PLN03142 405 GM-SQMQKQYYKAL--LQKDLDVVNAGGerkrlLNIAMQLRKccnhpYLFQG---AEPGPpyttgehlVENSGKMVLldk 478
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 335 ------QNDSlKFLVFAHHLSMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTR-VAILSIQAAGQGLTFT 407
Cdd:PLN03142 479 llpklkERDS-RVLIFSQMTRLLDILEDYLMYRGYQYCRIDGNTGGEDRDASIDAFNKPGSEKfVFLLSTRAGGLGINLA 557
|
410 420 430
....*....|....*....|....*....|....*
gi 557440797 408 AASHVVFAELYWDPGHIKQAEDRAHRIGQCSSVNI 442
Cdd:PLN03142 558 TADIVILYDSDWNPQVDLQAQDRAHRIGQKKEVQV 592
|
|
| DEXDc |
smart00487 |
DEAD-like helicases superfamily; |
29-216 |
1.82e-20 |
|
DEAD-like helicases superfamily;
Pssm-ID: 214692 [Multi-domain] Cd Length: 201 Bit Score: 90.63 E-value: 1.82e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 29 LPDRLRAKLLPFQKDGIIFALKRNGRCMVADEMGLGKTIQAI--GITYFYKEEWPL-LIVVP-SSLRYPWTEEIEKWIPE 104
Cdd:smart00487 1 IEKFGFEPLRPYQKEAIEALLSGLRDVILAAPTGSGKTLAALlpALEALKRGKGGRvLVLVPtRELAEQWAEELKKLGPS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 105 LSPEEINVI--QNKTDVRRMSTSK---VTVLGYGLLTADAKTliDALNNQNFKVVIVDESHYMKSRNATRS-RILLPIVQ 178
Cdd:smart00487 81 LGLKVVGLYggDSKREQLRKLESGktdILVTTPGRLLDLLEN--DKLSLSNVDLVILDEAHRLLDGGFGDQlEKLLKLLP 158
|
170 180 190 200
....*....|....*....|....*....|....*....|
gi 557440797 179 KARRAILLTGTPALGRPE--ELFMQIEALFPQKFGRWTDY 216
Cdd:smart00487 159 KNVQLLLLSATPPEEIENllELFLNDPVFIDVGFTPLEPI 198
|
|
| DEXHc_HELLS_SMARCA6 |
cd18009 |
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or ... |
36-258 |
3.75e-20 |
|
DEXH-box helicase domain of HELLS; HELLS (helicase, lymphoid specific, also known as Lsh or SMARCA6) is a major epigenetic regulator crucial for normal heterochromatin structure and function. HELLS is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350767 [Multi-domain] Cd Length: 236 Bit Score: 90.91 E-value: 3.75e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 36 KLLPFQKDGI--IFALKRNG-RCMVADEMGLGKTIQAIGITYFYKEE--W-PLLIVVPSSLRYPWTEEIEKWIPelspeE 109
Cdd:cd18009 3 VMRPYQLEGMewLRMLWENGiNGILADEMGLGKTIQTIALLAHLRERgvWgPFLVIAPLSTLPNWVNEFARFTP-----S 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 110 INVI------QNKTDVRRMSTSK--------VTVLGYGLLTADAKtlidALNNQNFKVVIVDESHYMKSRNATRSRILLP 175
Cdd:cd18009 78 VPVLlyhgtkEERERLRKKIMKRegtlqdfpVVVTSYEIAMRDRK----ALQHYAWKYLIVDEGHRLKNLNCRLIQELKT 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 176 IVQKARraILLTGTPALGRPEELFMQIEALFP------QKFGRWTDYAKryCNAhiRYFGKRPQWDCRGASNLNELHQLL 249
Cdd:cd18009 154 FNSDNR--LLLTGTPLQNNLSELWSLLNFLLPdvfddlSSFESWFDFSS--LSD--NAADISNLSEEREQNIVHMLHAIL 227
|
....*....
gi 557440797 250 SDIMIRRLK 258
Cdd:cd18009 228 KPFLLRRLK 236
|
|
| DEXHc_RAD54 |
cd18004 |
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are ... |
37-256 |
6.11e-20 |
|
DEXH-box helicase domain of RAD54; RAD54 proteins play a role in recombination. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350762 [Multi-domain] Cd Length: 240 Bit Score: 90.04 E-value: 6.11e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKR-------NGR-CMVADEMGLGKTIQAIGITyfykeeWPLL--------------IVVPSSLRYPW 94
Cdd:cd18004 1 LRPHQREGVQFLYDCltgrrgyGGGgAILADEMGLGKTLQAIALV------WTLLkqgpygkptakkalIVCPSSLVGNW 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 95 TEEIEKWIPE-------LSPEEINVIQNKTDVRRMSTSKVTVLGYGLLTADAKTLIDAlnnQNFKVVIVDESHYMKSRNA 167
Cdd:cd18004 75 KAEFDKWLGLrrikvvtADGNAKDVKASLDFFSSASTYPVLIISYETLRRHAEKLSKK---ISIDLLICDEGHRLKNSES 151
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 168 TRSRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRyfGKRPQWDCR----GASNLN 243
Cdd:cd18004 152 KTTKALNSL--PCRRRLLLTGTPIQNDLDEFFALVDFVNPGILGSLASFRKVFEEPILR--SRDPDASEEdkelGAERSQ 227
|
250
....*....|...
gi 557440797 244 ELHQLLSDIMIRR 256
Cdd:cd18004 228 ELSELTSRFILRR 240
|
|
| DEXHc_ERCC6L2 |
cd18005 |
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as ... |
37-220 |
6.42e-20 |
|
DEXH-box helicase domain of ERCC6L2; ERCC excision repair 6 like 2 (ERCC6L2, also known as RAD26L) may play a role in DNA repair and mitochondrial function. In humans, mutations in the ERCC6L2 gene are associated with bone marrow failure syndrome 2. ERCC6L2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350763 [Multi-domain] Cd Length: 245 Bit Score: 90.13 E-value: 6.42e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFA---LKRNGRCMVADEMGLGKTIQAIGI------------------TYFYKEEW------PLLIVVPSS 89
Cdd:cd18005 1 LRDYQREGVEFMydlYKNGRGGILGDDMGLGKTVQVIAFlaavlgktgtrrdrennrPRFKKKPPassakkPVLIVAPLS 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 90 LRYPWTEEIEKWipelSPEEINVI--QNKTDVrRMSTSK-----VTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYM 162
Cdd:cd18005 81 VLYNWKDELDTW----GHFEVGVYhgSRKDDE-LEGRLKagrleVVVTTYDTLRRC----IDSLNSINWSAVIADEAHRI 151
|
170 180 190 200 210
....*....|....*....|....*....|....*....|....*....|....*...
gi 557440797 163 KSRNATRSRILLPIVQKARraILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRY 220
Cdd:cd18005 152 KNPKSKLTQAMKELKCKVR--IGLTGTLLQNNMKELWCLLDWAVPGALGSRSQFKKHF 207
|
|
| DEXQc_INO80 |
cd18002 |
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 ... |
52-256 |
7.46e-20 |
|
DEAQ-box helicase domain of INO80; INO80 is the catalytic ATPase subunit of the INO80 chromatin remodeling complex. INO80 removes histone H3-containing nucleosomes from associated chromatin, promotes CENP-ACnp1 chromatin assembly at the centromere in a redundant manner with another chromatin-remodeling factor Chd1Hrp1. INO80 mutants have severe defects in oxygen consumption and promiscuous cell division that is no longer coupled with metabolic status. INO80 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350760 [Multi-domain] Cd Length: 229 Bit Score: 89.87 E-value: 7.46e-20
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIGITYFYKEE---W-PLLIVVPSSLRYPWTEEIEKWIPEL-------SPEEINVIQNKTDVR 120
Cdd:cd18002 21 NG--ILADEMGLGKTVQSIAVLAHLAEEhniWgPFLVIAPASTLHNWQQEISRFVPQFkvlpywgNPKDRKVLRKFWDRK 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 121 RMSTSK----VTVLGYGLLTADAKTlidaLNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRPE 196
Cdd:cd18002 99 NLYTRDapfhVVITSYQLVVQDEKY----FQRVKWQYMVLDEAQAIKSSSSSRWKTLLSF--HCRNRLLLTGTPIQNSMA 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557440797 197 ELFMQIEALFPQKFGRWTDYAKrycnahirYFGKRPQWDCRGASNLNE-----LHQLLSDIMIRR 256
Cdd:cd18002 173 ELWALLHFIMPTLFDSHDEFNE--------WFSKDIESHAENKTGLNEhqlkrLHMILKPFMLRR 229
|
|
| DEXHc_RAD54B |
cd18066 |
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as ... |
37-220 |
1.43e-19 |
|
DEXH-box helicase domain of RAD54B; DNA repair and recombination protein RAD54B, also known as RDH54, binds to double-stranded DNA, displays ATPase activity in the presence of DNA, and may have a role in meiotic and mitotic recombination. RAD54B is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350824 [Multi-domain] Cd Length: 235 Bit Score: 89.13 E-value: 1.43e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIF------ALKRNGR--CMVADEMGLGKTIQAIGITYFYKEEWP---------LLIVVPSSLRYPWTEEIE 99
Cdd:cd18066 1 LRPHQREGIEFlyecvmGMRVNERfgAILADEMGLGKTLQCISLIWTLLRQGPyggkpvikrALIVTPGSLVKNWKKEFQ 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 100 KWipeLSPEEINVIQNKTD--VRRMSTS---KVTVLGYGLLTADaktlIDALNNQNFKVVIVDESHYMKSRNATRSRILL 174
Cdd:cd18066 81 KW---LGSERIKVFTVDQDhkVEEFIASplySVLIISYEMLLRS----LDQISKLNFDLVICDEGHRLKNTSIKTTTALT 153
|
170 180 190 200
....*....|....*....|....*....|....*....|....*.
gi 557440797 175 PIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRY 220
Cdd:cd18066 154 SL--SCERRIILTGTPIQNDLQEFFALIDFVNPGILGSLSTYRKVY 197
|
|
| DEXHc_CHD2 |
cd18054 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; ... |
51-256 |
1.92e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 2; Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. CHD2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350812 [Multi-domain] Cd Length: 237 Bit Score: 88.91 E-value: 1.92e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 51 RNGRCMVADEMGLGKTIQAIG-ITYFYKEEW---PLLIVVPSSLRYPWTEEIEKWIPelspeEINVIQNKTDVRRMST-- 124
Cdd:cd18054 38 KNNSVILADEMGLGKTIQTISfLSYLFHQHQlygPFLLVVPLSTLTSWQREFEIWAP-----EINVVVYIGDLMSRNTir 112
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 125 ------SKVTVLGYGLLTADAKTLID---ALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARraILLTGTPALGRP 195
Cdd:cd18054 113 eyewihSQTKRLKFNALITTYEILLKdktVLGSINWAFLGVDEAHRLKNDDSLLYKTLIDFKSNHR--LLITGTPLQNSL 190
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|..
gi 557440797 196 EELFMQIEALFPQKFGRWTDYAKRYcnahiryfGKrpqwdcrGASN-LNELHQLLSDIMIRR 256
Cdd:cd18054 191 KELWSLLHFIMPEKFEFWEDFEEDH--------GK-------GRENgYQSLHKVLEPFLLRR 237
|
|
| DEXHc_CHD3_4_5 |
cd17994 |
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; ... |
37-256 |
2.23e-19 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding proteins 3, 4 and 5; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD3, CHD4, and CHD5 are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350752 [Multi-domain] Cd Length: 196 Bit Score: 87.49 E-value: 2.23e-19
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITY-FYKE---EWPLLIVVPSSLRYPWTEEIEKWIPELSpee 109
Cdd:cd17994 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTIQTIVFLYsLYKEghsKGPFLVSAPLSTIINWEREFEMWAPDFY--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 110 inVIQNKTDvrrmstsKVTVLGYGLLTADAKTlidaLNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGT 189
Cdd:cd17994 78 --VVTYVGD-------HVLLTSYELISIDQAI----LGSIDWAVLVVDEAHRLKNNQSKFFRILNSY--KIGYKLLLTGT 142
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557440797 190 PALGRPEELFMQIEALFPQKFGRWTDYAKRYCNahiryFGKRPQwdcrgasnLNELHQLLSDIMIRR 256
Cdd:cd17994 143 PLQNNLEELFHLLNFLTPERFNNLQGFLEEFAD-----ISKEDQ--------IKKLHDLLGPHMLRR 196
|
|
| DEXHc_CHD1_2 |
cd17993 |
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and ... |
36-256 |
1.59e-18 |
|
DEXH-box helicase domain of the chromodomain helicase DNA binding proteins 1 and 2, and similar proteins; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as the substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but is also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. Chromodomain-helicase-DNA-binding protein 2 (CHD2) is a DNA-binding helicase that specifically binds to the promoter of target genes, leading to chromatin remodeling, possibly by promoting deposition of histone H3.3. It is involved in myogenesis via interaction with MYOD1; it binds to myogenic gene regulatory sequences and mediates incorporation of histone H3.3 prior to the onset of myogenic gene expression, promoting their expression. Both are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350751 [Multi-domain] Cd Length: 218 Bit Score: 85.49 E-value: 1.59e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 36 KLLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITYF----YKEEWPLLIVVPSSLRYPWTEEIEKWIPELspe 108
Cdd:cd17993 1 ELRDYQLTGLnwlAHSWCKGNNGILADEMGLGKTVQTISFLSYlfhsQQQYGPFLVVVPLSTMPAWQREFAKWAPDM--- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 109 eiNVI-----QNKTDVRR---MSTSKVTVLGYG-LLTADAKTLID--ALNNQNFKVVIVDESHYMKSRNATRSRILLPIV 177
Cdd:cd17993 78 --NVIvylgdIKSRDTIReyeFYFSQTKKLKFNvLLTTYEIILKDkaFLGSIKWQYLAVDEAHRLKNDESLLYEALKEFK 155
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557440797 178 QKARraILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRYfgkrpqwdcrgasnLNELHQLLSDIMIRR 256
Cdd:cd17993 156 TNNR--LLITGTPLQNSLKELWALLHFLMPGKFDIWEEFEEEHDEEQEKG--------------IADLHKELEPFILRR 218
|
|
| DEXHc_SMARCA5 |
cd18064 |
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent ... |
35-268 |
9.91e-18 |
|
DEAH-box helicase domain of SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5 (SMARCA5, also called SNF2H) is the catalytic subunit of the four known chromatin-remodeling complexes: CHRAC, RSF, ACF/WCRF, and WICH. SMARCA5 plays a major role organising arrays of nucleosomes adjacent to the binding sites for the architectural transcription factor CTCF sites and acts to promote CTCF binding SMARCA5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350822 [Multi-domain] Cd Length: 244 Bit Score: 83.95 E-value: 9.91e-18
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 35 AKLLPFQKDGI--IFALKRNG-RCMVADEMGLGKTIQAIGITYFYKE----EWPLLIVVPSSLRYPWTEEIEKWIPELsp 107
Cdd:cd18064 14 GKLRDYQVRGLnwLISLYENGiNGILADEMGLGKTLQTISLLGYMKHyrniPGPHMVLVPKSTLHNWMAEFKRWVPTL-- 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 108 EEINVIQNKT-------DVRRMSTSKVTVLGYGLLTADAKTlidaLNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKA 180
Cdd:cd18064 92 RAVCLIGDKDqraafvrDVLLPGEWDVCVTSYEMLIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KT 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 181 RRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKrycnahirYFGKRpqwDCRGASNLNE-LHQLLSDIMIRRLKT 259
Cdd:cd18064 166 TNRLLLTGTPLQNNLHELWALLNFLLPDVFNSAEDFDS--------WFDTN---NCLGDQKLVErLHMVLRPFLLRRIKA 234
|
....*....
gi 557440797 260 EVLTQLPPK 268
Cdd:cd18064 235 DVEKSLPPK 243
|
|
| DEXHc_CHD1L |
cd18006 |
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, ... |
37-256 |
1.18e-17 |
|
DEAH/Q-box helicase domain of CHD1L; Chromodomain helicase DNA binding protein 1 like (CHD1L, also known as ALC1) is involved in DNA repair by regulating chromatin relaxation following DNA damage. CHD1L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350764 [Multi-domain] Cd Length: 216 Bit Score: 82.87 E-value: 1.18e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKR----NGrCMVADEMGLGKTIQAIGITYFY----KEEWPLLIVVPSSLRYPWTEEIEKWIPELSpe 108
Cdd:cd18006 1 LRPYQLEGVNWLLQCraeqHG-CILGDEMGLGKTCQTISLLWYLagrlKLLGPFLVLCPLSVLDNWKEELNRFAPDLS-- 77
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 109 einVI------QNKTDVRR--MSTSKVTVlgygLLTADAKTLIDA--LNNQNFKVVIVDESHYMKSRNATRSRILLPivQ 178
Cdd:cd18006 78 ---VItymgdkEKRLDLQQdiKSTNRFHV----LLTTYEICLKDAsfLKSFPWASLVVDEAHRLKNQNSLLHKTLSE--F 148
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 179 KARRAILLTGTPALGRPEELFMQIEALFPQKFGRWT--DYAKRYCNAHiryfgkrpqwdcRGASNLNELHQLLSDIMIRR 256
Cdd:cd18006 149 SVDFRLLLTGTPIQNSLQELYALLSFIEPNVFPKDKldDFIKAYSETD------------DESETVEELHLLLQPFLLRR 216
|
|
| DEXHc_SMARCA1_SMARCA5 |
cd17997 |
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin ... |
52-258 |
6.30e-17 |
|
DEAH-box helicase domain of SMARCA1 and SMARCA5; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 and 5 (SMARCA1 and SMARCA5) are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350755 [Multi-domain] Cd Length: 222 Bit Score: 80.83 E-value: 6.30e-17
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIGITYFYKE----EWPLLIVVPSSLRYPWTEEIEKWIPELSpeeINVIQNKTDVR------R 121
Cdd:cd17997 24 NG--ILADEMGLGKTLQTISLLGYLKHykniNGPHLIIVPKSTLDNWMREFKRWCPSLR---VVVLIGDKEERadiirdV 98
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 122 MSTSK--VTVLGYGLLTADAKtlidALNNQNFKVVIVDESHYMKSRNATRSRILLPIVQKARraILLTGTPALGRPEELF 199
Cdd:cd17997 99 LLPGKfdVCITSYEMVIKEKT----VLKKFNWRYIIIDEAHRIKNEKSKLSQIVRLFNSRNR--LLLTGTPLQNNLHELW 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557440797 200 MQIEALFPQKFGRWTDYakrycnahiryfgkrPQW----DCRGASN--LNELHQLLSDIMIRRLK 258
Cdd:cd17997 173 ALLNFLLPDVFTSSEDF---------------DEWfnvnNCDDDNQevVQRLHKVLRPFLLRRIK 222
|
|
| DEXHc_Mot1 |
cd17999 |
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in ... |
37-256 |
1.05e-16 |
|
DEXH-box helicase domain of Mot1; Modifier of transcription 1 (Mot1, also known as TAF172 in eukaryotes) regulates transcription in association with TATA binding protein (TBP). Mot1, Ino80C, and NC2 function coordinately to regulate pervasive transcription in yeast and mammals. Mot1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350757 [Multi-domain] Cd Length: 232 Bit Score: 80.47 E-value: 1.05e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITY---------FYKEEWPLLIVVPSSLRYPWTEEIEKWIPE 104
Cdd:cd17999 1 LRPYQQEGInwlAFLNKYNLHGILCDDMGLGKTLQTLCILAsdhhkransFNSENLPSLVVCPPTLVGHWVAEIKKYFPN 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 105 --LSP-EEINVIQNKTDVRRMSTSK-VTVLGYGLLtadaKTLIDALNNQNFKVVIVDESHYMKSrnaTRSRILLPIVQ-K 179
Cdd:cd17999 81 afLKPlAYVGPPQERRRLREQGEKHnVIVASYDVL----RNDIEVLTKIEWNYCVLDEGHIIKN---SKTKLSKAVKQlK 153
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 180 ARRAILLTGTPALGRPEEL----------FMQIEALFPQKFGRwTDYAKRYCNAHIRYfgkrpqwDCRGASNLNELHQLL 249
Cdd:cd17999 154 ANHRLILSGTPIQNNVLELwslfdflmpgYLGTEKQFQRRFLK-PILASRDSKASAKE-------QEAGALALEALHKQV 225
|
....*..
gi 557440797 250 SDIMIRR 256
Cdd:cd17999 226 LPFLLRR 232
|
|
| DEXHc_ERCC6 |
cd18000 |
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, ... |
37-207 |
1.07e-16 |
|
DEXH-box helicase domain of ERCC6; ERCC excision repair 6, chromatin remodeling factor (ERCC6, also known Cockayne syndrome group B (CSB), Rad26 in Saccharomyces cerevisiae, and Rhp26 in Schizosaccharomyces pombe) is a DNA-binding protein that is important in transcription-coupled excision repair. ERCC6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350758 [Multi-domain] Cd Length: 193 Bit Score: 79.68 E-value: 1.07e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKRNGRC---MVADEMGLGKTIQAI----GITYFYKEEWPLLIVVPSSLRYPWTEEIEKWIPEL---- 105
Cdd:cd18000 1 LFKYQQTGVQWLWELHCQRvggILGDEMGLGKTIQIIaflaALHHSKLGLGPSLIVCPATVLKQWVKEFHRWWPPFrvvv 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 106 ---------SPEEINVIQNKTDVRRmstsKVTVLGYGLLT--ADAKTLIDALNNQNFKVVIVDESHYMKSRNATRSRIL- 173
Cdd:cd18000 81 lhssgsgtgSEEKLGSIERKSQLIR----KVVGDGGILITtyEGFRKHKDLLLNHNWQYVILDEGHKIRNPDAEITLACk 156
|
170 180 190
....*....|....*....|....*....|....*
gi 557440797 174 -LPIVQKarraILLTGTPALGRPEELFMQIEALFP 207
Cdd:cd18000 157 qLRTPHR----LILSGTPIQNNLKELWSLFDFVFP 187
|
|
| DEXQc_SRCAP |
cd18003 |
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or ... |
52-256 |
1.17e-16 |
|
DEXH/Q-box helicase domain of SRCAP; Snf2-related CBP activator (SRCAP, also known as SWR1 or DOMO1) is the core catalytic component of the multiprotein chromatin-remodeling SRCAP complex, that is necessary for the incorporation of the histone variant H2A.Z into nucleosomes. SRCAP is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350761 [Multi-domain] Cd Length: 223 Bit Score: 80.09 E-value: 1.17e-16
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 52 NGrcMVADEMGLGKTIQAIGITYF---YKEEW-PLLIVVPSSLRYPWTEEIEKWIPEL-------SPEEINviqnktdVR 120
Cdd:cd18003 21 NG--ILADEMGLGKTIQTIALLAHlacEKGNWgPHLIVVPTSVMLNWEMEFKRWCPGFkiltyygSAKERK-------LK 91
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 121 RMSTSK-----VTVLGYGLLTADAKtlidALNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRP 195
Cdd:cd18003 92 RQGWMKpnsfhVCITSYQLVVQDHQ----VFKRKKWKYLILDEAHNIKNFKSQRWQTLLNF--NTQRRLLLTGTPLQNSL 165
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557440797 196 EELFMQIEALFPQKFGRWTDYAKrycnahirYFGKRPQWDCRGASNLNE-----LHQLLSDIMIRR 256
Cdd:cd18003 166 MELWSLMHFLMPHIFQSHQEFKE--------WFSNPLTAMSEGSQEENEelvrrLHKVLRPFLLRR 223
|
|
| DEXHc_ATRX-like |
cd18007 |
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as ... |
37-220 |
1.22e-15 |
|
DEXH-box helicase domain of ATRX-like proteins; This family includes ATRX-like members such as transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) which is involved in transcriptional regulation and chromatin remodeling, and ARIP4 (also called androgen receptor-interacting protein 4, RAD54 like 2 or RAD54L2) which modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. They are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350765 [Multi-domain] Cd Length: 239 Bit Score: 77.72 E-value: 1.22e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIF----------ALKRNGRCMVADEMGLGKTIQAIGITYFYKEEWPL----LIVVPSSLRYPWTEEIEKWI 102
Cdd:cd18007 1 LKPHQVEGVRFlwsnlvgtdvGSDEGGGCILAHTMGLGKTLQVITFLHTYLAAAPRrsrpLVLCPASTLYNWEDEFKKWL 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 103 PELSPEEINVI---QNKTDVRRMSTSK-------VTVLGYGL---LTADAKT---------LIDALNNQNfkVVIVDESH 160
Cdd:cd18007 81 PPDLRPLLVLVslsASKRADARLRKINkwhkeggVLLIGYELfrnLASNATTdprlkqefiAALLDPGPD--LLVLDEGH 158
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 161 YMKSRNATRSRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRY 220
Cdd:cd18007 159 RLKNEKSQLSKALSKV--KTKRRILLTGTPLQNNLKEYWTMVDFARPKYLGTLKEFKKKF 216
|
|
| DEXHc_SMARCA2 |
cd18063 |
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent ... |
56-258 |
1.62e-15 |
|
DEXH-box helicase domain of SMARCA2; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 (SMARCA2, also known as brahma homolog) is a component of the BAF complex. SMARCA2 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350821 [Multi-domain] Cd Length: 251 Bit Score: 77.41 E-value: 1.62e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 56 MVADEMGLGKTIQAIG-ITYFYKEE---WPLLIVVPSSLRYPWTEEIEKWIP---ELSPEEINVIQnKTDVRRMSTSKVT 128
Cdd:cd18063 46 ILADEMGLGKTIQTIAlITYLMEHKrlnGPYLIIVPLSTLSNWTYEFDKWAPsvvKISYKGTPAMR-RSLVPQLRSGKFN 124
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 129 VL--GYGLLTADAKTLIDAlnnqNFKVVIVDESHYMKSRNATRSRILLPIVQKARRaILLTGTPALGRPEELFMQIEALF 206
Cdd:cd18063 125 VLltTYEYIIKDKHILAKI----RWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-ILLTGTPLQNKLPELWALLNFLL 199
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557440797 207 PQKFGRWTDYaKRYCNAHIRYFGKRpqwdcrgaSNLNE---------LHQLLSDIMIRRLK 258
Cdd:cd18063 200 PTIFKSCSTF-EQWFNAPFAMTGER--------VDLNEeetiliirrLHKVLRPFLLRRLK 251
|
|
| DEXHc_CHD1 |
cd18053 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; ... |
51-220 |
3.03e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 1; Chromodomain-helicase-DNA-binding protein 1 (CHD1) is an ATP-dependent chromatin-remodeling factor which functions as substrate recognition component of the transcription regulatory histone acetylation (HAT) complex SAGA. It regulates polymerase II transcription and is also required for efficient transcription by RNA polymerase I, and more specifically the polymerase I transcription termination step. It is not only involved in transcription-related chromatin-remodeling, but also required to maintain a specific chromatin configuration across the genome. CHD1 is also associated with histone deacetylase (HDAC) activity. It is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350811 [Multi-domain] Cd Length: 237 Bit Score: 76.63 E-value: 3.03e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 51 RNGRCMVADEMGLGKTIQAIG-ITYFYKEEW---PLLIVVPSSLRYPWTEEIEKWIPELSP----EEINViQNKTDVRRM 122
Cdd:cd18053 38 KGNSCILADEMGLGKTIQTISfLNYLFHEHQlygPFLLVVPLSTLTSWQREIQTWAPQMNAvvylGDINS-RNMIRTHEW 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 123 STSKVTVLGYGLLTADAKTLIDA---LNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRPEELF 199
Cdd:cd18053 117 MHPQTKRLKFNILLTTYEILLKDksfLGGLNWAFIGVDEAHRLKNDDSLLYKTLIDF--KSNHRLLITGTPLQNSLKELW 194
|
170 180
....*....|....*....|.
gi 557440797 200 MQIEALFPQKFGRWTDYAKRY 220
Cdd:cd18053 195 SLLHFIMPEKFSSWEDFEEEH 215
|
|
| DEXHc_CHD5 |
cd18057 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; ... |
37-256 |
3.30e-15 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 5; Chromodomain-helicase-DNA-binding protein 5 (CHD5) is a chromatin-remodeling protein that binds DNA through histones and regulates gene transcription. It is thought to specifically recognize and bind trimethylated 'Lys-27' (H3K27me3) and non-methylated 'Lys-4' of histone H3 and plays a role in the development of the nervous system by activating the expression of genes promoting neuron terminal differentiation. In parallel, it may also positively regulate the trimethylation of histone H3 at 'Lys-27' thereby specifically repressing genes that promote the differentiation into non-neuronal cell lineages. As a tumor suppressor, it regulates the expression of genes involved in cell proliferation and differentiation. In spermatogenesis, it probably regulates histone hyperacetylation and the replacement of histones by transition proteins in chromatin, a crucial step in the condensation of spermatid chromatin and the production of functional spermatozoa. CHD5 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350815 [Multi-domain] Cd Length: 232 Bit Score: 76.26 E-value: 3.30e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITY-FYKE---EWPLLIVVPSSLRYPWTEEIEKWIP------ 103
Cdd:cd18057 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQTIVFLYsLYKEghsKGPYLVSAPLSTIINWEREFEMWAPdfyvvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 104 --------------ELSPEEiNVIQNKTDVRRMSTS-----KVTVLGYGLLTADAKTlidaLNNQNFKVVIVDESHYMKS 164
Cdd:cd18057 81 ytgdkesrsvirenEFSFED-NAIRSGKKVFRMKKEaqikfHVLLTSYELITIDQAI----LGSIEWACLVVDEAHRLKN 155
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 165 RNATRSRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCnahiryfgkrpqwDCRGASNLNE 244
Cdd:cd18057 156 NQSKFFRVLNSY--KIDYKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKK 220
|
250
....*....|..
gi 557440797 245 LHQLLSDIMIRR 256
Cdd:cd18057 221 LHDLLGPHMLRR 232
|
|
| DEXQc_bact_SNF2 |
cd18013 |
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 ... |
39-226 |
7.47e-15 |
|
DEXQ-box helicase domain of bacterial SNF2 family proteins; Proteins belonging to the SNF2 family of DNA dependent ATPases are important members of the chromatin remodeling complexes that are implicated in epigenetic control of gene expression. The Snf2 family comprise a large group of ATP-hydrolyzing proteins that are ubiquitous in eukaryotes, but also present in eubacteria and archaea. The bacterial SNF2 present in this family are members of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350771 [Multi-domain] Cd Length: 218 Bit Score: 74.69 E-value: 7.47e-15
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 39 PFQKDGIIFALKRNGRCMVADeMGLGKT---IQAIGITYFYKEEWPLLIVVPSSL-RYPWTEEIEKWIPELSPEEINVIQ 114
Cdd:cd18013 3 PYQKVAINFIIEHPYCGLFLD-MGLGKTvttLTALSDLQLDDFTRRVLVIAPLRVaRSTWPDEVEKWNHLRNLTVSVAVG 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 115 NKTDVRRMSTSK--VTVLGYGLLtadaKTLIDALNNQ-NFKVVIVDESHYMKSRNATRSRILLPIVQKARRAILLTGTPA 191
Cdd:cd18013 82 TERQRSKAANTPadLYVINRENL----KWLVNKSGDPwPFDMVVIDELSSFKSPRSKRFKALRKVRPVIKRLIGLTGTPS 157
|
170 180 190
....*....|....*....|....*....|....*..
gi 557440797 192 LGRPEELFMQIEAL-FPQKFGR-WTDYAKRYCNAHIR 226
Cdd:cd18013 158 PNGLMDLWAQIALLdQGERLGRsITAYRERWFDPDKR 194
|
|
| Helicase_C |
pfam00271 |
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, ... |
330-435 |
1.19e-14 |
|
Helicase conserved C-terminal domain; The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.
Pssm-ID: 459740 [Multi-domain] Cd Length: 109 Bit Score: 71.09 E-value: 1.19e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 330 IKMMLQNDSLKFLVFAHHLSMLQaCTEAVIENKTRYIRIDGSVSSSERIHLVNQFqKDPDTRVaILSIQAAGQGLTFTAA 409
Cdd:pfam00271 7 LELLKKERGGKVLIFSQTKKTLE-AELLLEKEGIKVARLHGDLSQEEREEILEDF-RKGKIDV-LVATDVAERGLDLPDV 83
|
90 100
....*....|....*....|....*.
gi 557440797 410 SHVVFAELYWDPGHIKQAEDRAHRIG 435
Cdd:pfam00271 84 DLVINYDLPWNPASYIQRIGRAGRAG 109
|
|
| DEXHc_CHD4 |
cd18056 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; ... |
37-256 |
2.95e-14 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 4; Chromodomain-helicase-DNA-binding protein 4 (CHD4) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. CHD4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350814 [Multi-domain] Cd Length: 232 Bit Score: 73.56 E-value: 2.95e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQ-AIGITYFYKE---EWPLLIVVPSSLRYPWTEEIEKWIP------ 103
Cdd:cd18056 1 LHPYQLEGLnwlRFSWAQGTDTILADEMGLGKTVQtAVFLYSLYKEghsKGPFLVSAPLSTIINWEREFEMWAPdmyvvt 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 104 --------------ELSPEEiNVIQNKTDVRRMStSKVTVLGYGLLTADAKTLIDA--LNNQNFKVVIVDESHYMKSRNA 167
Cdd:cd18056 81 yvgdkdsraiirenEFSFED-NAIRGGKKASRMK-KEASVKFHVLLTSYELITIDMaiLGSIDWACLIVDEAHRLKNNQS 158
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 168 TRSRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCnahiryfgkrpqwDCRGASNLNELHQ 247
Cdd:cd18056 159 KFFRVLNGY--SLQHKLLLTGTPLQNNLEELFHLLNFLTPERFHNLEGFLEEFA-------------DIAKEDQIKKLHD 223
|
....*....
gi 557440797 248 LLSDIMIRR 256
Cdd:cd18056 224 MLGPHMLRR 232
|
|
| DEXHc_SMARCA4 |
cd18062 |
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent ... |
56-258 |
5.57e-14 |
|
DEXH-box helicase domain of SMARCA4; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 (SMARCA4, also known as transcription activator BRG1) is a component of the CREST-BRG1 complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. Mutation of SMARCA4 (BRG1), the ATPase of BAF (mSWI/SNF) and PBAF complexes, contributes to a range of malignancies and neurologic disorders. SMARCA4 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350820 [Multi-domain] Cd Length: 251 Bit Score: 73.15 E-value: 5.57e-14
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 56 MVADEMGLGKTIQAIG-ITY---FYKEEWPLLIVVPSSLRYPWTEEIEKWIPEL-------SPEeinviQNKTDVRRMST 124
Cdd:cd18062 46 ILADEMGLGKTIQTIAlITYlmeHKRINGPFLIIVPLSTLSNWVYEFDKWAPSVvkvsykgSPA-----ARRAFVPQLRS 120
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 125 SKVTVL--GYGLLTADAKTLIDAlnnqNFKVVIVDESHYMKSRNATRSRILLPIVQKARRaILLTGTPALGRPEELFMQI 202
Cdd:cd18062 121 GKFNVLltTYEYIIKDKQILAKI----RWKYMIVDEGHRMKNHHCKLTQVLNTHYVAPRR-LLLTGTPLQNKLPELWALL 195
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 557440797 203 EALFPQKFGRWTDYaKRYCNAHIRYFGKRpqwdcrgaSNLNE---------LHQLLSDIMIRRLK 258
Cdd:cd18062 196 NFLLPTIFKSCSTF-EQWFNAPFAMTGEK--------VDLNEeetiliirrLHKVLRPFLLRRLK 251
|
|
| DEXHc_ERCC6L |
cd18001 |
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint ... |
37-190 |
1.11e-13 |
|
DEXH-box helicase domain of ERCC6L; ERCC excision repair 6 like, spindle assembly checkpoint helicase (ERCC6L, also known as RAD26L) is an essential component of the mitotic spindle assembly checkpoint, by acting as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. ERCC6L is proposed to stimulate cancer cell proliferation by promoting cell cycle through a way of RAB31-MAPK-CDK2. ERCC6L is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350759 [Multi-domain] Cd Length: 232 Bit Score: 71.63 E-value: 1.11e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI-----IFALKRNGrcMVADEMGLGKTIQAIG-ITYFYKEEW--PLLIVVPSSLRYPWTEEIEKWIPEL--- 105
Cdd:cd18001 1 LYPHQREGVawlwsLHDGGKGG--ILADDMGLGKTVQICAfLSGMFDSGLikSVLVVMPTSLIPHWVKEFAKWTPGLrvk 78
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 106 -----SPEEINVIQNKTDVRRmstsKVTVLGYGLLTADAKTLiDALNNQNFK--VVIVDESHYMKSRNATRSRILLPIVQ 178
Cdd:cd18001 79 vfhgtSKKERERNLERIQRGG----GVLLTTYGMVLSNTEQL-SADDHDEFKwdYVILDEGHKIKNSKTKSAKSLREIPA 153
|
170
....*....|..
gi 557440797 179 KARraILLTGTP 190
Cdd:cd18001 154 KNR--IILTGTP 163
|
|
| DEXHc_HLTF1_SMARC3 |
cd18071 |
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as ... |
56-200 |
2.31e-13 |
|
DEXH-box helicase domain of HLTF1; Helicase like transcription factor (HLTF1, also known as HIP116 or SMARCA3) has both helicase and E3 ubiquitin ligase activities and ATP-dependent nucleosome-remodeling activity. HLTF1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350829 [Multi-domain] Cd Length: 239 Bit Score: 70.96 E-value: 2.31e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 56 MVADEMGLGKTIQAIGITYFYkeewPLLIVVPSSLRYPWTEEIEKWIpelSPEEINVIQ----NKT-DVRRMSTSKVTVL 130
Cdd:cd18071 52 ILADDMGLGKTLTTISLILAN----FTLIVCPLSVLSNWETQFEEHV---KPGQLKVYTyhggERNrDPKLLSKYDIVLT 124
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|.
gi 557440797 131 GYGLLTADAKTLIDA-LNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRPEELFM 200
Cdd:cd18071 125 TYNTLASDFGAKGDSpLHTINWLRVVLDEGHQIRNPNAQQTKAVLNL--SSERRWVLTGTPIQNSPKDLGS 193
|
|
| DEXHc_CHD3 |
cd18055 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; ... |
47-256 |
2.89e-13 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 3; Chromodomain-helicase-DNA-binding protein 3 (CHD3) is a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin by deacetylating histones. It is required for anchoring centrosomal pericentrin in both interphase and mitosis, for spindle organization and centrosome integrity. CHD3 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350813 [Multi-domain] Cd Length: 232 Bit Score: 70.43 E-value: 2.89e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 47 FALKRNGRCMVADEMGLGKTIQAIGITY-FYKE---EWPLLIVVPSSLRYPWTEEIEKWIP------------------- 103
Cdd:cd18055 14 FSWAQGTDTILADEMGLGKTIQTIVFLYsLYKEghtKGPFLVSAPLSTIINWEREFQMWAPdfyvvtytgdkdsraiire 93
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 104 -ELSPEEINVIQNKT--DVRRMSTSKVTVL--GYGLLTADAktliDALNNQNFKVVIVDESHYMKSRNATRSRILLPIvq 178
Cdd:cd18055 94 nEFSFDDNAVKGGKKafKMKREAQVKFHVLltSYELVTIDQ----AALGSIRWACLVVDEAHRLKNNQSKFFRVLNGY-- 167
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557440797 179 KARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCnahiryfgkrpqwDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18055 168 KIDHKLLLTGTPLQNNLEELFHLLNFLTPERFNNLEGFLEEFA-------------DISKEDQIKKLHDLLGPHMLRR 232
|
|
| HELICc |
smart00490 |
helicase superfamily c-terminal domain; |
360-435 |
3.51e-13 |
|
helicase superfamily c-terminal domain;
Pssm-ID: 197757 [Multi-domain] Cd Length: 82 Bit Score: 65.70 E-value: 3.51e-13
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557440797 360 ENKTRYIRIDGSVSSSERIHLVNQFQKDPdtRVAILSIQAAGQGLTFTAASHVVFAELYWDPGHIKQAEDRAHRIG 435
Cdd:smart00490 9 ELGIKVARLHGGLSQEEREEILDKFNNGK--IKVLVATDVAERGLDLPGVDLVIIYDLPWSPASYIQRIGRAGRAG 82
|
|
| DEXHc_SMARCA1 |
cd18065 |
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent ... |
46-258 |
4.43e-13 |
|
DEAH-box helicase domain of SMARCA1; SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 1 (SMARCA1, also called SNF2L) is a component of NURF (nucleosome-remodeling factor) and CERF (CECR2-containing-remodeling factor) complexes which promote the perturbation of chromatin structure in an ATP-dependent manner. SMARCA1 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350823 [Multi-domain] Cd Length: 233 Bit Score: 70.05 E-value: 4.43e-13
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 46 IFALKRNG-RCMVADEMGLGKTIQAIGITYFYKE----EWPLLIVVPSSLRYPWTEEIEKWIPELSPeeINVIQNKT--- 117
Cdd:cd18065 27 MISLYENGvNGILADEMGLGKTLQTIALLGYLKHyrniPGPHMVLVPKSTLHNWMNEFKRWVPSLRA--VCLIGDKDara 104
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 118 ----DVRRMSTSKVTVLGYGLLTADAKTlidaLNNQNFKVVIVDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALG 193
Cdd:cd18065 105 afirDVMMPGEWDVCVTSYEMVIKEKSV----FKKFNWRYLVIDEAHRIKNEKSKLSEIVREF--KTTNRLLLTGTPLQN 178
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 557440797 194 RPEELFMQIEALFPQKFGRWTDYAKrycnahirYFGKRpqwDCRGASNLNE-LHQLLSDIMIRRLK 258
Cdd:cd18065 179 NLHELWALLNFLLPDVFNSADDFDS--------WFDTK---NCLGDQKLVErLHAVLKPFLLRRIK 233
|
|
| DEXHc_RAD54A |
cd18067 |
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as ... |
37-256 |
1.35e-12 |
|
DEXH-box helicase domain of RAD54A; DNA repair and recombination protein RAD54A, also known as RAD54L or RAD54, plays a role in homologous recombination related repair of DNA double-strand breaks. RAD54A is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350825 [Multi-domain] Cd Length: 243 Bit Score: 68.65 E-value: 1.35e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALK----RNGR----CMVADEMGLGKTIQAIGITYFYKEEWP--------LLIVVPSSLRYPWTEEIEK 100
Cdd:cd18067 1 LRPHQREGVKFLYRcvtgRRIRgshgCIMADEMGLGKTLQCITLMWTLLRQSPqckpeidkAIVVSPSSLVKNWANELGK 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 101 WI-PELSPEEINVIQNKTDVR----------RMSTSKVTVLGYGLLTADAktliDALNNQNFKVVIVDESHYMKSRNATR 169
Cdd:cd18067 81 WLgGRLQPLAIDGGSKKEIDRklvqwasqqgRRVSTPVLIISYETFRLHV----EVLQKGEVGLVICDEGHRLKNSDNQT 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 170 SRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCNAHIRyfGK----RPQWDCRGASNLNEL 245
Cdd:cd18067 157 YQALDSL--NTQRRVLLSGTPIQNDLSEYFSLVNFVNPGILGTAAEFKKNFELPILK--GRdadaSEKERQLGEEKLQEL 232
|
250
....*....|.
gi 557440797 246 HQLLSDIMIRR 256
Cdd:cd18067 233 ISIVNRCIIRR 243
|
|
| DEXHc_CHD8 |
cd18060 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; ... |
37-256 |
1.36e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 8; Chromodomain-helicase-DNA-binding protein 8 (CHD8) is a DNA helicase that acts as a chromatin remodeling factor and regulates transcription. It also acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. It suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity and of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. It also acts as a negative regulator of Wnt signaling pathway and CTNNB1-targeted gene expression. CHD8 is also involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. It also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription. CHD8 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350818 [Multi-domain] Cd Length: 222 Bit Score: 68.16 E-value: 1.36e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGI---TYFYKEEWPLLIVVPSSLRYPWTEEIEKW------IPE 104
Cdd:cd18060 1 LREYQLEGVnwlLFNWYNRQNCILADEMGLGKTIQSIAFlqeVYNVGIHGPFLVIAPLSTITNWEREFNTWtemntiVYH 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 105 LSPEEINVIQNKTDVRRMSTSKVTVLGY---GLLTADAKTLIDA--LNNQNFKVVIVDESHYMKSRNAT--RSRILLPIV 177
Cdd:cd18060 81 GSLASRQMIQQYEMYCKDSRGRLIPGAYkfdALITTFEMILSDCpeLREIEWRCVIIDEAHRLKNRNCKllDSLKHMDLE 160
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....
gi 557440797 178 QKarraILLTGTPALGRPEELFMQIEALFPQKFGRWTDYakrycnahIRYFGkrpqwDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18060 161 HK----VLLTGTPLQNTVEELFSLLHFLEPSQFPSESEF--------LKDFG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_CHD6 |
cd18058 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; ... |
37-256 |
1.64e-12 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 6; Chromodomain-helicase-DNA-binding protein 6 (CHD6) is a DNA-dependent ATPase that plays a role in chromatin remodeling. It regulates transcription by disrupting nucleosomes in a largely non-sliding manner which strongly increases the accessibility of chromatin. It activates transcription of specific genes in response to oxidative stress through interaction with NFE2L2.2 and acts as a transcriptional repressor of different viruses including influenza virus or papillomavirus. During influenza virus infection, the viral polymerase complex localizes CHD6 to inactive chromatin where it gets degraded in a proteasome independent-manner. CHD6 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350816 [Multi-domain] Cd Length: 222 Bit Score: 68.14 E-value: 1.64e-12
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDG---IIFALKRNGRCMVADEMGLGKTIQAIGITY---FYKEEWPLLIVVPSSLRYPWTEEIEKWIpelspeEI 110
Cdd:cd18058 1 LREYQLEGmnwLLFNWYNRKNCILADEMGLGKTIQSITFLSeifLMGIRGPFLIIAPLSTITNWEREFRTWT------EM 74
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 111 NVI-QNKTDVRRMSTSKVTVLG--------------YGLLTADAKTLIDA--LNNQNFKVVIVDESHYMKSRNATRSRIL 173
Cdd:cd18058 75 NAIvYHGSQISRQMIQQYEMYYrdeqgnplsgifkfQVVITTFEMILADCpeLKKINWSCVIIDEAHRLKNRNCKLLEGL 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 174 LpiVQKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYakrycnahIRYFGkrpqwDCRGASNLNELHQLLSDIM 253
Cdd:cd18058 155 K--LMALEHKVLLTGTPLQNSVEELFSLLNFLEPSQFPSETTF--------LEEFG-----DLKTEEQVKKLQSILKPMM 219
|
...
gi 557440797 254 IRR 256
Cdd:cd18058 220 LRR 222
|
|
| DEXHc_CHD7 |
cd18059 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; ... |
37-256 |
1.14e-11 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 7; Chromodomain-helicase-DNA-binding protein 7 (CHD7) is a probable transcription regulator. It may be involved in the 45S precursor rRNA production. CHD7 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350817 [Multi-domain] Cd Length: 222 Bit Score: 65.44 E-value: 1.14e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI---IFALKRNGRCMVADEMGLGKTIQAIGITY-FYKE--EWPLLIVVPSSLRYPWTEEIEKWIpEL----- 105
Cdd:cd18059 1 LREYQLEGVnwlLFNWYNTRNCILADEMGLGKTIQSITFLYeIYLKgiHGPFLVIAPLSTIPNWEREFRTWT-ELnvvvy 79
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 106 --SPEEINVIQNKTDVRRMSTSKVTVLGY---GLLTADAKTLIDA--LNNQNFKVVIVDESHYMKSRNATRSRILLpiVQ 178
Cdd:cd18059 80 hgSQASRRTIQLYEMYFKDPQGRVIKGSYkfhAIITTFEMILTDCpeLRNIPWRCVVIDEAHRLKNRNCKLLEGLK--MM 157
|
170 180 190 200 210 220 230
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557440797 179 KARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRycnahiryFGkrpqwDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18059 158 DLEHKVLLTGTPLQNTVEELFSLLHFLEPSRFPSETTFMQE--------FG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| DEXHc_ARIP4 |
cd18069 |
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called ... |
40-220 |
2.02e-11 |
|
DEXH-box helicase domain of ARIP4; Androgen receptor-interacting protein 4 (ARIP4, also called RAD54 like 2 or RAD54L2 ) modulates androgen receptor (AR)-dependent transactivation in a promoter-dependent manner. ARIP4 is part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350827 [Multi-domain] Cd Length: 227 Bit Score: 64.84 E-value: 2.02e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 40 FQKDGIIFALKRNGR-----CMVADEMGLGKTIQAIGITYFYKEEWPL---LIVVPSSLRYPWTEEIEKWIPelSPEEIN 111
Cdd:cd18069 11 FLYDNIIESLERYKGssgfgCILAHSMGLGKTLQVISFLDVLLRHTGAktvLAIVPVNTLQNWLSEFNKWLP--PPEALP 88
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 112 VIQNKT-------DVRRMSTSKVTVlgygLLTADAKTLIDALNNQNFK------VVIVDESHYMKSRNATRSRILLPIvq 178
Cdd:cd18069 89 NVRPRPfkvfilnDEHKTTAARAKV----IEDWVKDGGVLLMGYEMFRlrpgpdVVICDEGHRIKNCHASTSQALKNI-- 162
|
170 180 190 200
....*....|....*....|....*....|....*....|..
gi 557440797 179 KARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRY 220
Cdd:cd18069 163 RSRRRIVLTGYPLQNNLIEYWCMVDFVRPDFLGTRQEFSNMF 204
|
|
| DEXHc_ATRX |
cd18068 |
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha ... |
37-222 |
2.91e-11 |
|
DEXH-box helicase domain of ATRX; Transcriptional regulator ATRX (also called alpha thalassemia/mental retardation syndrome X-linked and X-linked nuclear protein or XNP) is involved in transcriptional regulation and chromatin remodeling. Mutations in humans cause mental retardation, X-linked, syndromic, with hypotonic facies 1 (MRXSHF1) and alpha-thalassemia myelodysplasia syndrome (ATMDS). ATRX is part of the a DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350826 [Multi-domain] Cd Length: 246 Bit Score: 64.91 E-value: 2.91e-11
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIF-----------ALKRNGR-CMVADEMGLGKTIQAIGI--TYFYKEEWP----LLIVVPSSLRYPWTEEI 98
Cdd:cd18068 1 LKPHQVDGVQFmwdccceslkkTKKSPGSgCILAHCMGLGKTLQVVTFlhTVLLCEKLEnfsrVLVVCPLNTVLNWLNEF 80
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 99 EKWIPELSPE------EINVIQNKTDVRRM-----STSKVTVLGYGL---LTAD---------AKTLIDALNNQNFKVVI 155
Cdd:cd18068 81 EKWQEGLKDEekievnELATYKRPQERSYKlqrwqEEGGVMIIGYDMyriLAQErnvksreklKEIFNKALVDPGPDFVV 160
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557440797 156 VDESHYMKSRNATRSRILLPIvqKARRAILLTGTPALGRPEELFMQIEALFPQKFGRWTDYAKRYCN 222
Cdd:cd18068 161 CDEGHILKNEASAVSKAMNSI--RTKRRIVLTGTPLQNNLIEYHCMVNFVKPNLLGTIKEFRNRFVN 225
|
|
| DEXHc_CHD9 |
cd18061 |
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; ... |
50-256 |
6.61e-10 |
|
DEAH-box helicase domain of the chromodomain helicase DNA binding protein 9; Chromodomain-helicase-DNA-binding protein 9 (CHD9) acts as a transcriptional coactivator for PPARA and possibly other nuclear receptors. It is proposed to be a ATP-dependent chromatin remodeling protein. CHD9 has DNA-dependent ATPase activity and binds to A/T-rich DNA. It also associates with A/T-rich regulatory regions in promoters of genes that participate in the differentiation of progenitors during osteogenesis. CHD9 is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350819 [Multi-domain] Cd Length: 222 Bit Score: 60.40 E-value: 6.61e-10
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 50 KRNgrCMVADEMGLGKTIQAigITYFYK-----EEWPLLIVVPSSLRYPWTEEIEKW------IPELSPEEINVIQNKTD 118
Cdd:cd18061 19 RRN--CILADEMGLGKTIQS--ITFLYEilltgIRGPFLIIAPLSTIANWEREFRTWtdlnvvVYHGSLISRQMIQQYEM 94
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 119 VRRMSTSKVTVLGY---GLLTADAKTL--IDALNNQNFKVVIVDESHYMKSRNATRSRILLpiVQKARRAILLTGTPALG 193
Cdd:cd18061 95 YFRDSQGRIIRGAYrfqAIITTFEMILggCPELNAIDWRCVIIDEAHRLKNKNCKLLEGLK--LMNLEHKVLLTGTPLQN 172
|
170 180 190 200 210 220
....*....|....*....|....*....|....*....|....*....|....*....|...
gi 557440797 194 RPEELFMQIEALFPQKFGRWtdyakrycNAHIRYFGkrpqwDCRGASNLNELHQLLSDIMIRR 256
Cdd:cd18061 173 TVEELFSLLHFLEPLRFPSE--------STFMQEFG-----DLKTEEQVQKLQAILKPMMLRR 222
|
|
| SSL2 |
COG1061 |
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair]; |
36-415 |
9.86e-09 |
|
Superfamily II DNA or RNA helicase [Transcription, Replication, recombination, and repair];
Pssm-ID: 440681 [Multi-domain] Cd Length: 566 Bit Score: 59.27 E-value: 9.86e-09
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 36 KLLPFQKDGI--IFAL--KRNGRCMVADEMGLGKTIQAIGITYFYKEEWPLLIVVPS-SLRYPWTEEIEKWIPelspeei 110
Cdd:COG1061 80 ELRPYQQEALeaLLAAleRGGGRGLVVAPTGTGKTVLALALAAELLRGKRVLVLVPRrELLEQWAEELRRFLG------- 152
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 111 nvIQNKTDVRRMSTSKVTVLGYGLLTADAKtlIDALNNqNFKVVIVDESHYMKSRNATRSRILLPivqkARRAILLTGTP 190
Cdd:COG1061 153 --DPLAGGGKKDSDAPITVATYQSLARRAH--LDELGD-RFGLVIIDEAHHAGAPSYRRILEAFP----AAYRLGLTATP 223
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 191 AL--GRPEELFMqiealfpqkfgrwtdyakrycnahirYFGKRPQWDcrgasnlneLHQLLSDIMIRrlktevltqlPPK 268
Cdd:COG1061 224 FRsdGREILLFL--------------------------FDGIVYEYS---------LKEAIEDGYLA----------PPE 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 269 VRqRIPFDLpsaaakelntsfeewekimrTPNSGAMETVMGLITRMFKQTAIAKAGAVKDYIKMMLQNDslKFLVFAHHL 348
Cdd:COG1061 259 YY-GIRVDL--------------------TDERAEYDALSERLREALAADAERKDKILRELLREHPDDR--KTLVFCSSV 315
|
330 340 350 360 370 380
....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 557440797 349 SMLQACTEAVIENKTRYIRIDGSVSSSERIHLVNQFQKDPDTrvAILSIQAAGQGLTFTAASHVVFA 415
Cdd:COG1061 316 DHAEALAELLNEAGIRAAVVTGDTPKKEREEILEAFRDGELR--ILVTVDVLNEGVDVPRLDVAILL 380
|
|
| DEXHc_RE |
cd17926 |
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family ... |
37-190 |
2.75e-08 |
|
DEXH-box helicase domain of DEAD-like helicase restriction enzyme family proteins; This family is composed of helicase restriction enzymes and similar proteins such as TFIIH basal transcription factor complex helicase XPB subunit. These proteins are part of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350684 [Multi-domain] Cd Length: 146 Bit Score: 53.85 E-value: 2.75e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGI--IFALKRNGRCMVADEMGLGKTIQAIGITYFYKEEwPLLIVVPS-SLRYPWTEEIEKWipeLSPEEINVI 113
Cdd:cd17926 1 LRPYQEEALeaWLAHKNNRRGILVLPTGSGKTLTALALIAYLKEL-RTLIVVPTdALLDQWKERFEDF---LGDSSIGLI 76
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 557440797 114 Q-NKTDVRRmsTSKVTVLGYGLLTADAKTLIDALNnqNFKVVIVDESHYMKSRNATRsriLLPIVQKARRaILLTGTP 190
Cdd:cd17926 77 GgGKKKDFD--DANVVVATYQSLSNLAEEEKDLFD--QFGLLIVDEAHHLPAKTFSE---ILKELNAKYR-LGLTATP 146
|
|
| HNHc |
cd00085 |
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic ... |
1009-1047 |
1.02e-07 |
|
HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and anaredoxins.
Pssm-ID: 238038 [Multi-domain] Cd Length: 57 Bit Score: 49.39 E-value: 1.02e-07
10 20 30
....*....|....*....|....*....|....*....
gi 557440797 1009 PGEGHFWQVDHIKPVYGGGgQCSLDNLQTLCTVCHKERT 1047
Cdd:cd00085 20 PGGTEGLEVDHIIPLSDGG-NNDLDNLVLLCRKCHRKKH 57
|
|
| DpdE |
NF041062 |
protein DpdE; |
54-215 |
1.11e-07 |
|
protein DpdE;
Pssm-ID: 468989 [Multi-domain] Cd Length: 1048 Bit Score: 56.13 E-value: 1.11e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 54 RCMVADEMGLGKTIQAiGI----TYFYKEEWPLLIVVPSSLRypwteeiEKWIPELSpeeinviqNKTDVRRMSTSKVTV 129
Cdd:NF041062 172 RYLLADEVGLGKTIEA-GLvirqHLLDNPDARVLVLVPDALV-------RQWRRELR--------DKFFLDDFPGARVRV 235
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 130 LGYG-LLTADAKTlidalnnQNFKVVIVDESHYM-------KSRNATRSRILLPIVQKARRAILLTGTPALGRPEELFMQ 201
Cdd:NF041062 236 LSHEePERWEPLL-------DAPDLLVVDEAHQLarlawsgDPPERARYRELAALAHAAPRLLLLSATPVLGNEETFLAL 308
|
170
....*....|....
gi 557440797 202 IEALFPQKFgRWTD 215
Cdd:NF041062 309 LHLLDPDLY-PLDD 321
|
|
| ResIII |
pfam04851 |
Type III restriction enzyme, res subunit; |
36-190 |
5.34e-06 |
|
Type III restriction enzyme, res subunit;
Pssm-ID: 398492 [Multi-domain] Cd Length: 162 Bit Score: 47.67 E-value: 5.34e-06
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 36 KLLPFQKDGI----IFALKRNGRCMVADEMGLGKTIQAIGITYFYKEEWPL---LIVVPS-SLRYPWTEEIEKWIPElSP 107
Cdd:pfam04851 3 ELRPYQIEAIenllESIKNGQKRGLIVMATGSGKTLTAAKLIARLFKKGPIkkvLFLVPRkDLLEQALEEFKKFLPN-YV 81
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 108 EEINVIQNKTDVRRMSTSKVTVLGY-GLLTADAKTLIDALNNQnFKVVIVDESHYMksrNATRSRILLPIVQKARRaILL 186
Cdd:pfam04851 82 EIGEIISGDKKDESVDDNKIVVTTIqSLYKALELASLELLPDF-FDVIIIDEAHRS---GASSYRNILEYFKPAFL-LGL 156
|
....
gi 557440797 187 TGTP 190
Cdd:pfam04851 157 TATP 160
|
|
| HNH |
pfam01844 |
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic ... |
1014-1049 |
3.19e-05 |
|
HNH endonuclease; His-Asn-His (HNH) proteins are a very common family of small nucleic acid-binding proteins that are generally associated with endonuclease activity.
Pssm-ID: 396422 [Multi-domain] Cd Length: 47 Bit Score: 42.34 E-value: 3.19e-05
10 20 30
....*....|....*....|....*....|....*.
gi 557440797 1014 FWQVDHIKPVYGGGGQcSLDNLQTLCTVCHKERTAR 1049
Cdd:pfam01844 13 ALTVDHIIPLSDGGAD-DIENLILLCPSCHNKKHNR 47
|
|
| McrA |
COG1403 |
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms]; |
1009-1044 |
4.60e-05 |
|
5-methylcytosine-specific restriction endonuclease McrA [Defense mechanisms];
Pssm-ID: 441013 [Multi-domain] Cd Length: 64 Bit Score: 42.28 E-value: 4.60e-05
10 20 30
....*....|....*....|....*....|....*.
gi 557440797 1009 PGEGHFWQVDHIKPVYGGGGQcSLDNLQTLCTVCHK 1044
Cdd:COG1403 28 PFSGDALEVDHIIPRSRGGTD-TWENLVLLCRRCNR 62
|
|
| DEXQc_SHPRH |
cd18070 |
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously ... |
37-103 |
4.89e-05 |
|
DEXQ-box helicase domain of SHPRH; E3 ubiquitin-protein ligase SHPRH is a ubiquitously expressed protein that contains motifs characteristic of several DNA repair proteins, transcription factors, and helicases. SHPRH is a functional homolog of S. cerevisiae RAD5 and is involved in DNA repair. SHPRH is a member of the DEAD-like helicase superfamily, a diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
Pssm-ID: 350828 [Multi-domain] Cd Length: 257 Bit Score: 46.18 E-value: 4.89e-05
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 557440797 37 LLPFQKDGIIFALKRNGrcMVADEMGLGKTIQAIGI-------------TYFYKEEWPL----------------LIVVP 87
Cdd:cd18070 1 LLPYQRRAVNWMLVPGG--ILADEMGLGKTVEVLALillhprpdndldaADDDSDEMVCcpdclvaetpvsskatLIVCP 78
|
90
....*....|....*.
gi 557440797 88 SSLRYPWTEEIEKWIP 103
Cdd:cd18070 79 SAILAQWLDEINRHVP 94
|
|
| zf-RanBP |
pfam00641 |
Zn-finger in Ran binding protein and others; |
625-647 |
7.72e-05 |
|
Zn-finger in Ran binding protein and others;
Pssm-ID: 395516 [Multi-domain] Cd Length: 30 Bit Score: 40.80 E-value: 7.72e-05
|
| HNHc |
smart00507 |
HNH nucleases; |
1015-1043 |
2.86e-04 |
|
HNH nucleases;
Pssm-ID: 214702 [Multi-domain] Cd Length: 52 Bit Score: 39.75 E-value: 2.86e-04
10 20
....*....|....*....|....*....
gi 557440797 1015 WQVDHIKPvYGGGGQCSLDNLQTLCTVCH 1043
Cdd:smart00507 24 LEVDHIIP-LSDGGNDDLDNLVLLCPKCH 51
|
|
| ZnF_RBZ |
smart00547 |
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. ... |
625-647 |
1.28e-03 |
|
Zinc finger domain; Zinc finger domain in Ran-binding proteins (RanBPs), and other proteins. In RanBPs, this domain binds RanGDP.
Pssm-ID: 197784 [Multi-domain] Cd Length: 25 Bit Score: 37.30 E-value: 1.28e-03
|
| |
