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Conserved domains on  [gi|555943681|ref|NP_001273195|]
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magnesium transporter MRS2 homolog, mitochondrial isoform d [Homo sapiens]

Protein Classification

CorA family magnesium transporter( domain architecture ID 10191269)

CorA family magnesium transporter, belonging to the CorA metal ion transporter (MIT) family, mediates the influx of magnesium ions, similar to mitochondrial inner membrane magnesium transporter MRS2

CATH:  1.20.58.340
Gene Ontology:  GO:0015095|GO:1903830|GO:0016020
PubMed:  17619822|18927203|16720382
SCOP:  4000404|4000464
TCDB:  1.A.35

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 89-349 6.40e-70

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


:

Pssm-ID: 213357  Cd Length: 323  Bit Score: 222.89  E-value: 6.40e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681  89 YLKAVITPECLLILDYRNLN-------LEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLI 161
Cdd:cd12823   58 HIRAIITADEVLLFDPDGSSsalvsafLEELQRRLASSNGSESESGGEDSLPFEFRALEAALEEVCSHLEAELKRLEPEA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 162 LETLDALVDpkhsSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEE 241
Cdd:cd12823  138 LPLLDELTD----KISTSNLERLLPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEE 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 242 MELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDH 321
Cdd:cd12823  214 VEMLLEAYLQQVDELLNKLEELREYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESP 293

                        250       260
                 ....*....|....*....|....*...
gi 555943681 322 RIFWLITGIMFMGSGLIWRRLLSFLGRQ 349
Cdd:cd12823  294 YAFWIVTGGSVVGSILIFIVVLRYLRRK 321
 
Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 89-349 6.40e-70

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 222.89  E-value: 6.40e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681  89 YLKAVITPECLLILDYRNLN-------LEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLI 161
Cdd:cd12823   58 HIRAIITADEVLLFDPDGSSsalvsafLEELQRRLASSNGSESESGGEDSLPFEFRALEAALEEVCSHLEAELKRLEPEA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 162 LETLDALVDpkhsSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEE 241
Cdd:cd12823  138 LPLLDELTD----KISTSNLERLLPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEE 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 242 MELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDH 321
Cdd:cd12823  214 VEMLLEAYLQQVDELLNKLEELREYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESP 293

                        250       260
                 ....*....|....*....|....*...
gi 555943681 322 RIFWLITGIMFMGSGLIWRRLLSFLGRQ 349
Cdd:cd12823  294 YAFWIVTGGSVVGSILIFIVVLRYLRRK 321
 
Name Accession Description Interval E-value
Mrs2_Mfm1p-like cd12823
Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like ...
 89-349 6.40e-70

Saccharomyces cerevisiae inner mitochondrial membrane Mg2+ transporters Mfm1p and Mrs2p-like family; A eukaryotic subfamily belonging to the Escherichia coli CorA-Salmonella typhimurium ZntB_like family (EcCorA_ZntB-like) family of the MIT superfamily of essential membrane proteins involved in transporting divalent cations (uptake or efflux) across membranes. This functionally diverse subfamily includes the inner mitochondrial membrane Mg2+ transporters Saccharomyces cerevisiae Mfm1p/Lpe10p, Mrs2p, and human MRS2/ MRS2L. It also includes a family of Arabidopsis thaliana proteins (AtMGTs) some of which are localized to distinct tissues, and not all of which can transport Mg2+. Structures of the intracellular domain of two EcCorA_ZntB-like family transporters: Vibrio parahaemolyticus and Salmonella typhimurium ZntB form funnel-shaped homopentamers, the tip of the funnel is formed from two C-terminal transmembrane (TM) helices from each monomer, and the large opening of the funnel from the N-terminal cytoplasmic domains. The GMN signature motif of the MIT superfamily occurs just after TM1, mutation within this motif is known to abolish Mg2+ transport through Salmonella typhimurium CorA, and Mrs2p. Natural variants such as GVN and GIN, as in some ZntB family proteins, may be associated with the transport of different divalent cations, such as zinc and cadmium. The functional diversity of MIT transporters may also be due to minor structural differences regulating gating, substrate selection, and transport.


Pssm-ID: 213357  Cd Length: 323  Bit Score: 222.89  E-value: 6.40e-70
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681  89 YLKAVITPECLLILDYRNLN-------LEQWLFRELPSQLSGEGQLVTYPLPFEFRAIEALLQYWINTLQGKLSILQPLI 161
Cdd:cd12823   58 HIRAIITADEVLLFDPDGSSsalvsafLEELQRRLASSNGSESESGGEDSLPFEFRALEAALEEVCSHLEAELKRLEPEA 137

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 162 LETLDALVDpkhsSVDRSKLHILLQNGKSLSELETDIKIFKESILEILDEEELLEELCVSKWSDPQVFEKSSAGIDHAEE 241
Cdd:cd12823  138 LPLLDELTD----KISTSNLERLLPLKRRLVELETRVQKVRDALEELLDDDEDMADMYLTDKAAGPERLESSRKEDDHEE 213

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 555943681 242 MELLLENYYRLADDLSNAARELRVLIDDSQSIIFINLDSHRNVMMRLNLQLTMGTFSLSLFGLMGVAFGMNLESSLEEDH 321
Cdd:cd12823  214 VEMLLEAYLQQVDELLNKLEELREYIDDTEELINLILDSRRNQLMRLELKLSIGTLSLAVGTLVAGLFGMNLPSGLEESP 293

                        250       260
                 ....*....|....*....|....*...
gi 555943681 322 RIFWLITGIMFMGSGLIWRRLLSFLGRQ 349
Cdd:cd12823  294 YAFWIVTGGSVVGSILIFIVVLRYLRRK 321
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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