|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
48-504 |
1.19e-87 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 274.34 E-value: 1.19e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 48 LGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEatsaateagl 127
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALG---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 128 elvdkgkakelpgsqvifegptlgqqeDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNF 207
Cdd:COG0471 71 ---------------------------SEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP---ISF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 208 ASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcgleSKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILW 287
Cdd:COG0471 121 FEWMLVGLPVALVGLLLLWLVLYRLLPP------------EIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLW 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 288 FSRDPGFMPgwltvawvegetkyvsDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWKVTQEKVPWGI 367
Cdd:COG0471 189 ITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSIPWGV 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 368 VLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLY 446
Cdd:COG0471 229 LLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLP 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 548960531 447 IMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTW 504
Cdd:COG0471 309 LALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
35-509 |
5.26e-76 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 247.29 E-value: 5.26e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 35 VCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKParLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQ 114
Cdd:pfam00939 77 ALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIM 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 115 QMEATSaateaglelvdkgkakelpGSQVifegptlgqqEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQM 194
Cdd:pfam00939 155 SLPPAF-------------------GSDP----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLM 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 195 NELfpdSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSwgcgleskknekAALKVLQEEYRKLGPLSFAEI 274
Cdd:pfam00939 206 NSI---LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREK 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 275 NVLICFFLLVILWFSrdpgfmpgwltvawveGETKYVSDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLL 354
Cdd:pfam00939 271 ALLGLFVLLLLLWIF----------------GGSLNIDATTVAIIGLALMLL------------------------LRIL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 355 DWK-VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPL--HAVPPAAITLILSLLVAVFTECTSNVATTTLFLP 431
Cdd:pfam00939 311 DWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLP 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 432 IFASMSRSI-GLNPLYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIF 509
Cdd:pfam00939 391 IFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
32-505 |
2.88e-61 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 205.90 E-value: 2.88e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 32 PAKVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEA 111
Cdd:cd01115 37 PKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 112 ILQQMEATsaateaglelvdkgkakelpgsqvifegptlgqqedqerkrlCKAMTLCICYAASIGGTATLTGTGPNVVLL 191
Cdd:cd01115 117 LAAKLDIS------------------------------------------PSRLLMPLAFAASIGGMLTLIGTPPNLVAS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 192 GQMNELFPDSkdlVNFASWFAFAFPNMLVMLLFAWLWLqfvymrfnfkkswgcgleskknekaalkvlqeeyrklgplsf 271
Cdd:cd01115 155 GYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIF------------------------------------------ 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 272 aeINVLICFFLLVILWFSRDPGFMPgwltvawvegetkyVSDATVAIFVATLLFIVpsqkpkfnfrsqteeerktpfypp 351
Cdd:cd01115 190 --RLAVLIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVFGGV------------------------ 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 352 plLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFL 430
Cdd:cd01115 230 --LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLA 307
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960531 431 PIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWG 505
Cdd:cd01115 308 PIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
46-504 |
2.55e-44 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 162.13 E-value: 2.55e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 46 LFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARL-MLGFMGVTALLSMWISNTA-TTAMMVPIVEAILqqmeatsaat 123
Cdd:TIGR00785 68 LFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLL---------- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 124 eaglelvdkgkakelpgsqvifegPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfPDSKD 203
Cdd:TIGR00785 138 ------------------------PLLGSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILS---KILGI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 204 LVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcglESKKNEKAALkVLQEEYRKLGPLSFAEINVLICFFLL 283
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLFPP-----------ELKLKDEVDL-WAKEELEEMGPMSFREKALLGIFLLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 284 VILWFSrdpgfmpgwltvawveGETKYVSDATVAIFVATLLFIVPsqkpkfnfrsqteeerktpfypppLLDWK-VTQEK 362
Cdd:TIGR00785 259 LLLWIF----------------GGSLGINASVVALLAVVLMLFLG------------------------IVTWKdIQKNK 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 363 VPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMSRSI 440
Cdd:TIGR00785 299 VAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQ 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960531 441 GLNPLYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFcVFLAVNTW 504
Cdd:TIGR00785 379 GIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
|
|
| |
|
Name |
Accession |
Description |
Interval |
E-value |
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
48-504 |
1.19e-87 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 274.34 E-value: 1.19e-87
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 48 LGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEatsaateagl 127
Cdd:COG0471 1 LGGFVLAAALEKTGLGRRIALLLLKRFGGSPLRLLLGLMLATALLSAFISNTARAAMMLPIALSIAAALG---------- 70
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 128 elvdkgkakelpgsqvifegptlgqqeDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDSkdlVNF 207
Cdd:COG0471 71 ---------------------------SEKRSKFGSALLLPIAFAASIGGMGTLIGTPPNLIAAGLLEEATGIP---ISF 120
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 208 ASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcgleSKKNEKAALKVLQEEYRKLGPLSFAEINVLICFFLLVILW 287
Cdd:COG0471 121 FEWMLVGLPVALVGLLLLWLVLYRLLPP------------EIKEVPGSKEVIREELAELGPLSRREKIALAIFALTVLLW 188
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 288 FSRDPGFMPgwltvawvegetkyvsDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLLDWKVTQEKVPWGI 367
Cdd:COG0471 189 ITGSLHGIP----------------IAVVALLGAVLLLL------------------------TGVLTWKDAYKSIPWGV 228
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 368 VLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNPLY 446
Cdd:COG0471 229 LLLFGGGLALGAALEKTGLAAWLADALLPlLGGLSPLLLLLLLALLTLLLTEFASNTATAALLLPIAISLAQALGVNPLP 308
|
410 420 430 440 450
....*....|....*....|....*....|....*....|....*....|....*...
gi 548960531 447 IMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTW 504
Cdd:COG0471 309 LALAVAFAASCAFLLPVGTPPNAIVYGSGYYKFKDFLKVGLPLNLIGLVVLLLLGPLW 366
|
|
| Na_sulph_symp |
pfam00939 |
Sodium:sulfate symporter transmembrane region; There are also some members in this family that ... |
35-509 |
5.26e-76 |
|
Sodium:sulfate symporter transmembrane region; There are also some members in this family that do not match the Prosite motif, and belong to the subfamily SODIT1.
Pssm-ID: 279307 [Multi-domain] Cd Length: 472 Bit Score: 247.29 E-value: 5.26e-76
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 35 VCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKParLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQ 114
Cdd:pfam00939 77 ALSGFSSTTTWLVFGAFFISAAFEKTGLGRRIALVLVKKMGKRT--LGLGYGLVFSDLLLAPATPSNTARAGGIVFPIIM 154
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 115 QMEATSaateaglelvdkgkakelpGSQVifegptlgqqEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQM 194
Cdd:pfam00939 155 SLPPAF-------------------GSDP----------EKGSERRIGAYLMWTVYQSTSITSAMFLTAMAPNLLLLGLM 205
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 195 NELfpdSKDLVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRFNFKKSwgcgleskknekAALKVLQEEYRKLGPLSFAEI 274
Cdd:pfam00939 206 NSI---LGVTITWASWFLAAIPPGVILLLLAPLLLYVLYPPEIKSVP------------DAKAIAKTELKELGPMTFREK 270
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 275 NVLICFFLLVILWFSrdpgfmpgwltvawveGETKYVSDATVAIFVATLLFIvpsqkpkfnfrsqteeerktpfypPPLL 354
Cdd:pfam00939 271 ALLGLFVLLLLLWIF----------------GGSLNIDATTVAIIGLALMLL------------------------LRIL 310
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 355 DWK-VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPL--HAVPPAAITLILSLLVAVFTECTSNVATTTLFLP 431
Cdd:pfam00939 311 DWKdIVKNKGAWNTLIWLGGLIMLANGLERSGFIEWLGNTLSTSlsGFSPAMAFIIILSLFYLSHYLFASATAHTAAMLP 390
|
410 420 430 440 450 460 470 480
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 432 IFASMSRSI-GLNPLYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIF 509
Cdd:pfam00939 391 IFAAVAQAIpGAPPLLAALLLGFAISLGgFLTPYGTGPGPIYFGSGYLKVKDWWRIGAILTIIGLLILLLLGNWWWKPLG 470
|
|
| SLC13_permease |
cd01115 |
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been ... |
32-505 |
2.88e-61 |
|
Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is related to renal and intestinal Na+/sulfate cotransporters and a few putative bacterial permeases. The SLC13-type proteins belong to the ArsB/NhaD superfamily of permeases that translocate sodium and various anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease is composed of 8-13 transmembrane helices.
Pssm-ID: 238535 [Multi-domain] Cd Length: 382 Bit Score: 205.90 E-value: 2.88e-61
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 32 PAKVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEA 111
Cdd:cd01115 37 PKEAFSGFSDPAVILFLAGFILGAALTRTGLAKRIATKLLKRAGKGERRLLLLLMLVTAFLSAFMSNTATVAIMLPVALG 116
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 112 ILQQMEATsaateaglelvdkgkakelpgsqvifegptlgqqedqerkrlCKAMTLCICYAASIGGTATLTGTGPNVVLL 191
Cdd:cd01115 117 LAAKLDIS------------------------------------------PSRLLMPLAFAASIGGMLTLIGTPPNLVAS 154
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 192 GQMNELFPDSkdlVNFASWFAFAFPNMLVMLLFAWLWLqfvymrfnfkkswgcgleskknekaalkvlqeeyrklgplsf 271
Cdd:cd01115 155 GYLESLGGQG---FSFFEFTPIGLPLLIIGLLYLWFIF------------------------------------------ 189
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 272 aeINVLICFFLLVILWFSRDPGFMPgwltvawvegetkyVSDATVAIFVATLLFIVpsqkpkfnfrsqteeerktpfypp 351
Cdd:cd01115 190 --RLAVLIITIVLLAALAAITGLLP--------------VSVAIAIGAIVLVFGGV------------------------ 229
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 352 plLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVFTECTSNVATTTLFL 430
Cdd:cd01115 230 --LLTKEDYKSIDWGIIFLFAGGIPLGKALESSGAAALIAEALISlLGGLPPFAILLLLCLLTLVLTNFISNTATAVLLA 307
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960531 431 PIFASMSRSIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWG 505
Cdd:cd01115 308 PIALSIALSLGLPPEALLLAVAIGASCAFMLPVGTPPNAIVLGPGGYKFSDFAKVGLPLSILSLVVSVTMIPLIW 382
|
|
| dass |
TIGR00785 |
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally ... |
46-504 |
2.55e-44 |
|
anion transporter; The Divalent Anion:Na+ Symporter (DASS) Family (TC 2.A.47) Functionally characterized proteins of the DASS family transport (1) organic di- and tricarboxylates of the Krebs Cycle as well as dicarboxylate amino acid, (2) inorganic sulfate and (3) phosphate. The animal NaDC-1 cotransport 3 Na+ with each dicarboxylate. Protonated tricarboxylates are also cotransported with 3Na+. [Transport and binding proteins, Anions, Transport and binding proteins, Cations and iron carrying compounds]
Pssm-ID: 273267 [Multi-domain] Cd Length: 444 Bit Score: 162.13 E-value: 2.55e-44
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 46 LFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARL-MLGFMGVTALLSMWISNTA-TTAMMVPIVEAILqqmeatsaat 123
Cdd:TIGR00785 68 LFFGAFILATALVKTGLGKRIAYKLVGKMGGTTLGLgYFLVFLETLLAPMWPSNTArAGGILLPIIKSLL---------- 137
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 124 eaglelvdkgkakelpgsqvifegPTLGQQEDQERKRLCKAMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfPDSKD 203
Cdd:TIGR00785 138 ------------------------PLLGSKPEKSPRKIGKYLMLGIAYSASIGSSGFLTGSAPNALAAGILS---KILGI 190
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 204 LVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcglESKKNEKAALkVLQEEYRKLGPLSFAEINVLICFFLL 283
Cdd:TIGR00785 191 QISWGDWFLAGLPLGIILLLLVPLLLYVLFPP-----------ELKLKDEVDL-WAKEELEEMGPMSFREKALLGIFLLA 258
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 284 VILWFSrdpgfmpgwltvawveGETKYVSDATVAIFVATLLFIVPsqkpkfnfrsqteeerktpfypppLLDWK-VTQEK 362
Cdd:TIGR00785 259 LLLWIF----------------GGSLGINASVVALLAVVLMLFLG------------------------IVTWKdIQKNK 298
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 363 VPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEP-LHAVPPAAITLILSLLVAVF-TECTSNVATTTLFLPIFASMSRSI 440
Cdd:TIGR00785 299 VAWNTLILFGGLIGLAGGLKKSGFIKWFSEKLVGiLDGLSPTIAVLVLVVLFYIIlYFFASNTAHTAALVPIFFSVASAQ 378
|
410 420 430 440 450 460
....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960531 441 GLNPLYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFcVFLAVNTW 504
Cdd:TIGR00785 379 GIPLELLALALALSASLMgFLTPYATPPNAIAYGSGYVKIKDMWRVGAIIGIVGLI-VLLLVGTL 442
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
32-501 |
1.52e-35 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 137.00 E-value: 1.52e-35
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 32 PAKVCVQYMKDTNMLFLGGLIVAVAVERWNLHKRIALRtLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEA 111
Cdd:cd00625 30 PKEALSAIDWETILLLFGMMILSAALEETGLFDRLAAK-LARASKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLA 108
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 112 ILQqmeatsaateaglelvdkgKAKELPGSQVIfegptlgqqedqerkrlckamtLCICYAASIGGTATLTGTGPNVVLL 191
Cdd:cd00625 109 LLR-------------------KLGLSPPVPLL----------------------LALAFAANIGGAATPIGNPPNLIIA 147
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 192 GQMNelfpdskdlVNFASWFAFAFPNMLVMLLFAWLWLQFVYMRfnfkkswgcglESKKNEKAALKVLQEEYRKLGPLSF 271
Cdd:cd00625 148 SLSG---------LGFLDFLAFMAPPALGLLLLLLGLLYLLFRK-----------KLLLPDEDKLTVLAEPLPARPLLKK 207
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 272 AEINVLICFFLLVILWFSRDPGFMPgwltvawvegetkyvsdATVAIFVATLLFIVpsqkpkfnfrsqteeerktpfypp 351
Cdd:cd00625 208 FLLLALLLLLLFVLLFFFLIPLGLI-----------------ALLGALLLLLLLVR------------------------ 246
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 352 pLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLP 431
Cdd:cd00625 247 -GLDPEEVLKSVDWGTLLFFAGLFVLVGALESTGLLEWLAELLVALVGLPPLAALLLIGLLSALLSNFISNVPTVALLLP 325
|
410 420 430 440 450 460 470
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 548960531 432 IFASMSR-----SIGLNPLYIMLPCTLSASFAFMLPVATPPNAIVftygHLKVADMVKTGVIMNIIGVFCVFLAV 501
Cdd:cd00625 326 IAASLAPpepawLALALGSTLGGNLTLIGSLANLIPLGAAENAGV----GISFGEFLKVGLPLTLLSLVVSLLYL 396
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
42-449 |
2.46e-22 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 98.15 E-value: 2.46e-22
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 42 DTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVeailqqmeatsa 121
Cdd:pfam03600 40 PTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIMIPIV------------ 107
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 122 ateagLELVDKGKAKELPgsqvifegptlgqqedqerkrlckaMTLCICYAASIGGTATLTGTGPNVVLLGQMNELFPDS 201
Cdd:pfam03600 108 -----LALARRLGLPPSP-------------------------LLIALAFAANIGGTATPIGDPPNIIIASALGLSFGDF 157
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 202 KdlvnFASWFAFAFPNMLVMLLFAWLWLqfvymrfnfkkswgcgleskKNEKAALKVLQEEYRKLGPLSFAEINVLICFF 281
Cdd:pfam03600 158 G----FFMFPPVGVALLLVGLLPLLLIF--------------------RKLLPVRKEEEAELEELRKRAIKDKLLLAISA 213
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 282 LLVILWFSRDPGFMPGWLTVAWVEGETKyvsdatvaifvatllfivpsqkpkfnfrsqteeerktpfypppLLDWKVTQE 361
Cdd:pfam03600 214 LVLALVILGFLLLSVLALAGALLLLLTG-------------------------------------------VLDPEEALK 250
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 362 KVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHavPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIG 441
Cdd:pfam03600 251 AVDWSTLLFFAGLFILVGALEKTGLADALADALGGLS--GLLVALALILWLSALLSAFISNVPTAALMAPIIVGMAPAAG 328
|
....*...
gi 548960531 442 LNPLYIML 449
Cdd:pfam03600 329 LGDPDPLA 336
|
|
| CitMHS |
pfam03600 |
Citrate transporter; |
350-501 |
3.42e-08 |
|
Citrate transporter;
Pssm-ID: 460985 [Multi-domain] Cd Length: 342 Bit Score: 55.40 E-value: 3.42e-08
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 350 PPPLLDWKVTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLF 429
Cdd:pfam03600 24 LLGVLTPEEALSGIDSPTILLLLGMMIIGAILERTGLFDRLALKLLRLAGGKPRRLLVALMLATALLSAFLSNDGTVLIM 103
|
90 100 110 120 130 140 150
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548960531 430 LPIFASMSRSIGLNPLYIMLPCTLSASFAFML-PVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAV 501
Cdd:pfam03600 104 IPIVLALARRLGLPPSPLLIALAFAANIGGTAtPIGDPPNIIIASALGLSFGDFGFFMFPPVGVALLLVGLLP 176
|
|
| ArsB_NhaD_permease |
cd00625 |
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, ... |
365-524 |
1.22e-07 |
|
Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a channel-forming subunit of an ATP-driven anion pump.
Pssm-ID: 238344 [Multi-domain] Cd Length: 396 Bit Score: 53.79 E-value: 1.22e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 365 WGIVLLLGGGFALAKGSEASGLSVWMGKQMEpLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNP 444
Cdd:cd00625 39 WETILLLFGMMILSAALEETGLFDRLAAKLA-RASKGSRRLLLLLMLLTAALSAFFSNDATAVLLTPIVLALLRKLGLSP 117
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 445 -LYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFLAVNTWGRAIFDLDHFPDWANVTH 522
Cdd:cd00625 118 pVPLLLALAFAANIGgAATPIGNPPNLIIASLSGLGFLDFLAFMAPPALGLLLLLLGLLYLLFRKKLLLPDEDKLTVLAE 197
|
..
gi 548960531 523 IE 524
Cdd:cd00625 198 PL 199
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
45-449 |
2.06e-07 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 53.21 E-value: 2.06e-07
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 45 MLFLGGLIVAVAV-ERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVeailqqmeatsaat 123
Cdd:COG1055 56 ILFLLGMMIIVAIlDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVV-------------- 121
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 124 eagLELVDKGKAKELPgsqvifegptlgqqedqerkrlckaMTLCICYAASIGGTATLTGTGPNVVLLGQMNelfpdskd 203
Cdd:COG1055 122 ---LAIARRLGLNPVP-------------------------FLIAIVFAANIGGAATPIGNPTNIMIASAGG-------- 165
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 204 lVNFASWFAFAFPNMLVMLLFAWLWLQFVymrfnFKKSWGCGLESKKNEKAALKvlqeeYRKLGPLSFAEINVLICFFLL 283
Cdd:COG1055 166 -LSFLDFLANLFPPSLVSLLVTLLVLYLL-----FRKELPAAPDLEDDPKEAIK-----DRRLLRISLLVLALLLVGFVL 234
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 284 VILWfsrdpGFMPGWltvawvegetkyvsdatVAIFVATLLFIVPSQKPKFNFRsqteeerktpfyppplldwkvtqeKV 363
Cdd:COG1055 235 HSFL-----GLPPAL-----------------IALLGAAVLLLLARVDVREVLK------------------------KV 268
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 364 PWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLN 443
Cdd:COG1055 269 DWSTLLFFIGLFVVVGGLENTGLLDLLAELLASLTGGNLLLAALLILWLSAILSAVVDNVPLVAALLPLIPDLGATGNPE 348
|
....*.
gi 548960531 444 PLYIML 449
Cdd:COG1055 349 PLWLAL 354
|
|
| ArsB |
COG1055 |
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism]; |
365-499 |
1.49e-04 |
|
Na+/H+ antiporter NhaD or related arsenite permease [Inorganic ion transport and metabolism];
Pssm-ID: 440675 [Multi-domain] Cd Length: 415 Bit Score: 44.35 E-value: 1.49e-04
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 365 WGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMSRSIGLNP 444
Cdd:COG1055 53 WNTILFLLGMMIIVAILDESGFFEWLAIKLARRAKGSPRRLLWLLGLLTALLSAFLDNDTTALLLTPVVLAIARRLGLNP 132
|
90 100 110 120 130
....*....|....*....|....*....|....*....|....*....|....*.
gi 548960531 445 LYIMLPCTLSASFA-FMLPVATPPNAIVFTYGHLKVADMVKTGVIMNIIGVFCVFL 499
Cdd:COG1055 133 VPFLIAIVFAANIGgAATPIGNPTNIMIASAGGLSFLDFLANLFPPSLVSLLVTLL 188
|
|
| P_permease |
cd01116 |
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible ... |
42-458 |
3.58e-03 |
|
Permease P (pink-eyed dilution). Mutations in the human melanosomal P gene were responsible for classic phenotype of oculocutaneous albinism type 2 (OCA2). Although the precise function of the P protein is unknown, it was predicted to regulate the intraorganelle pH, together with the ATP-driven proton pump. It shows significant sequence similarity to the Na+/H+ antiporter NhaD from Vibrio parahaemolyticus. Both proteins belong to ArsB/NhaD superfamily of permeases that translocate sodium, arsenate, sulfate, and organic anions across biological membranes in all three kingdoms of life. A typical ArsB/NhaD permease contains 8-13 transmembrane domains.
Pssm-ID: 238536 [Multi-domain] Cd Length: 413 Bit Score: 39.93 E-value: 3.58e-03
10 20 30 40 50 60 70 80
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 42 DTNMLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLMLGFMGVTALLSMWISNTATTAMMVPIVEAILQQMEatsa 121
Cdd:cd01116 48 ETLALLLGMMIIVSILSETGVFEYLAIWAVKISKGRPWRLLLLLGLLTAFLSAFLDNVTTVLLMVPVTIRLCEVLG---- 123
|
90 100 110 120 130 140 150 160
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 122 ateaglelvdkgkakelpgsqvIFEGPTLgqqedqerkrlckamtLCICYAASIGGTATLTGTGPNVVLlgqmnelfpDS 201
Cdd:cd01116 124 ----------------------LNPVPVL----------------ISEVIAANIGGAATLIGDPPNIMI---------GS 156
|
170 180 190 200 210 220 230 240
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 202 KDLVNFASWFAFAFPnMLVMLLFAwlwlQFVYMRFNFKKSWgcgLESKKNEKAALKVLQEEYRKLGPL----SFAEINVL 277
Cdd:cd01116 157 AAGLTFNDFLLHMLP-SVVLALVV----TFILLYFLYRNIL---KAREEDVLALAELEPKYPIKDKVLllksLTILTLVI 228
|
250 260 270 280 290 300 310 320
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 278 ICFFLLVILWFSrdpgfmPGWltvawvegetkyvsdatVAIFVATLLFIVPSQkpkfnfrsqteeerktpfyppplLDWK 357
Cdd:cd01116 229 IGFVLHSPLGVS------LGW-----------------IALLGALLLLLLADK-----------------------LDFE 262
|
330 340 350 360 370 380 390 400
....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548960531 358 VTQEKVPWGIVLLLGGGFALAKGSEASGLSVWMGKQMEPLHAVPPAAITLILSLLVAVFTECTSNVATTTLFLPIFASMS 437
Cdd:cd01116 263 DVLSRVEWDTLLFFAGLFVLVGGLEELGIIEWIAELLVGVILGRIAVAVILILWISALLSAFIDNIPVTATMIPIVKDLA 342
|
410 420
....*....|....*....|.
gi 548960531 438 RSIGLNPLYIMLPCTLSASFA 458
Cdd:cd01116 343 SQLGIPLLPLWWALALGACLG 363
|
|
| CitT |
COG0471 |
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism]; |
45-116 |
5.71e-03 |
|
Di- and tricarboxylate antiporter [Carbohydrate transport and metabolism];
Pssm-ID: 440239 [Multi-domain] Cd Length: 369 Bit Score: 38.98 E-value: 5.71e-03
10 20 30 40 50 60 70
....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 548960531 45 MLFLGGLIVAVAVERWNLHKRIALRTLLWVGAKPARLML-GFMGVTALLSMWISNTATTAMMVPIVEAILQQM 116
Cdd:COG0471 230 LLFGGGLALGAALEKTGLAAWLADALLPLLGGLSPLLLLlLLALLTLLLTEFASNTATAALLLPIAISLAQAL 302
|
|
| |
