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Conserved domains on  [gi|548923801|ref|NP_001271296|]
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NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 8, mitochondrial isoform 2 [Homo sapiens]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
NDUF_B8 super family cl05413
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of ...
 21-164 2.70e-82

NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits.


The actual alignment was detected with superfamily member pfam05821:

Pssm-ID: 428637  Cd Length: 167  Bit Score: 240.16  E-value: 2.70e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923801   21 VMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLN 100
Cdd:pfam05821   2 VVPRGARAASPLTKDMKPGPYPKTPEERAAAAKKYNMRPEDYQPYPDDGMGYGDYPDLPVRSQDERDPYYQWDHPDLRRN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 548923801  101 WGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVCRHHFSYN 164
Cdd:pfam05821  82 WGEPVHWDMDMYIRNRVDTSPTPTTWNTMRKHLRVFVPMMLFMFYFGEEYPSYQPVGPKQYPYN 145
 
Name Accession Description Interval E-value
NDUF_B8 pfam05821
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of ...
 21-164 2.70e-82

NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits.


Pssm-ID: 428637  Cd Length: 167  Bit Score: 240.16  E-value: 2.70e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923801   21 VMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLN 100
Cdd:pfam05821   2 VVPRGARAASPLTKDMKPGPYPKTPEERAAAAKKYNMRPEDYQPYPDDGMGYGDYPDLPVRSQDERDPYYQWDHPDLRRN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 548923801  101 WGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVCRHHFSYN 164
Cdd:pfam05821  82 WGEPVHWDMDMYIRNRVDTSPTPTTWNTMRKHLRVFVPMMLFMFYFGEEYPSYQPVGPKQYPYN 145
 
Name Accession Description Interval E-value
NDUF_B8 pfam05821
NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of ...
 21-164 2.70e-82

NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI or NDUFB8); This family consists of several eukaryotic NADH-ubiquinone oxidoreductase ASHI subunit (CI-ASHI) proteins. NADH:ubiquinone oxidoreductase (complex I) is an extremely complicated multiprotein complex located in the inner mitochondrial membrane. Its main function is the transport of electrons from NADH to ubiquinone, which is accompanied by translocation of protons from the mitochondrial matrix to the intermembrane space. Human complex I appears to consist of 41 subunits.


Pssm-ID: 428637  Cd Length: 167  Bit Score: 240.16  E-value: 2.70e-82
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 548923801   21 VMPLGARTASHMTKDMFPGPYPRTPEERAAAAKKYNMRVEDYEPYPDDGMGYGDYPKLPDRSQHERDPWYSWDQPGLRLN 100
Cdd:pfam05821   2 VVPRGARAASPLTKDMKPGPYPKTPEERAAAAKKYNMRPEDYQPYPDDGMGYGDYPDLPVRSQDERDPYYQWDHPDLRRN 81

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 548923801  101 WGEPMHWHLDMYNRNRVDTSPTPVSWHVMCMQLFGFLAFMIFMCWVGDVYPVYQPVCRHHFSYN 164
Cdd:pfam05821  82 WGEPVHWDMDMYIRNRVDTSPTPTTWNTMRKHLRVFVPMMLFMFYFGEEYPSYQPVGPKQYPYN 145
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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