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Conserved domains on  [gi|547234824|ref|NP_001271248|]
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nuclear receptor coactivator 4 isoform b [Mus musculus]

Protein Classification

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 104-239 1.49e-58

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 190.72  E-value: 1.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  104 VSLSEWLLVSKPAIGLQAPYVPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSSKC 183
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  184 NSHCSTSSFSPEAEKAEDVELLDQDEL----DLSDWLVTPQEPCELEKPvdgswETSEKF 239
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 super family cl13870
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 2-52 1.24e-03

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


The actual alignment was detected with superfamily member pfam12489:

Pssm-ID: 463604  Cd Length: 135  Bit Score: 39.33  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 547234824    2 GQFNCLIHQLEYTQNK--DLANQVSvcLERLGSLALKPEDSTVLLFEADTSAL 52
Cdd:pfam12489  85 GTSSFSIEQLKVSDLEllDQEEQLT--LEDLSDWLLTPEESPKLEFPADSEKL 135
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 104-239 1.49e-58

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 190.72  E-value: 1.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  104 VSLSEWLLVSKPAIGLQAPYVPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSSKC 183
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  184 NSHCSTSSFSPEAEKAEDVELLDQDEL----DLSDWLVTPQEPCELEKPvdgswETSEKF 239
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 2-52 1.24e-03

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 39.33  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 547234824    2 GQFNCLIHQLEYTQNK--DLANQVSvcLERLGSLALKPEDSTVLLFEADTSAL 52
Cdd:pfam12489  85 GTSSFSIEQLKVSDLEllDQEEQLT--LEDLSDWLLTPEESPKLEFPADSEKL 135
 
Name Accession Description Interval E-value
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 104-239 1.49e-58

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 190.72  E-value: 1.49e-58
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  104 VSLSEWLLVSKPAIGLQAPYVPSTNPQDWLIPKQTSENSQTSARACSFFSDAWGNLKGLENWLLNSHQQEIAGKPSSSKC 183
Cdd:pfam12489   1 VPLSEWLLGSKPISGCQAPYQPSTNLQDWLTQKQTKENSQVSARACSCFSRVWGNLRDLENWLLKQQQLVVPLKPEQQQL 80

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|
gi 547234824  184 NSHCSTSSFSPEAEKAEDVELLDQDEL----DLSDWLVTPQEPCELEKPvdgswETSEKF 239
Cdd:pfam12489  81 NSLSGTSSFSIEQLKVSDLELLDQEEQltleDLSDWLLTPEESPKLEFP-----ADSEKL 135
ARA70 pfam12489
Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 ...
 2-52 1.24e-03

Nuclear coactivator; This domain family is found in eukaryotes, and is typically between 127 and 138 amino acids in length. This family is ARA70, a nuclear coactivator which interacts with peroxisome proliferator-activated receptor gamma (PPARgamma) to regulate transcription and the addition of the PPARgamma ligand (prostaglandin J2) enhances this interaction.


Pssm-ID: 463604  Cd Length: 135  Bit Score: 39.33  E-value: 1.24e-03
                          10        20        30        40        50
                  ....*....|....*....|....*....|....*....|....*....|...
gi 547234824    2 GQFNCLIHQLEYTQNK--DLANQVSvcLERLGSLALKPEDSTVLLFEADTSAL 52
Cdd:pfam12489  85 GTSSFSIEQLKVSDLEllDQEEQLT--LEDLSDWLLTPEESPKLEFPADSEKL 135
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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