NCBI Home Page NCBI Site Search page NCBI Guide that lists and describes the NCBI resources
Conserved domains on  [gi|544583512|ref|NP_001269793|]
View 

solute carrier family 2, facilitated glucose transporter member 11 isoform d [Homo sapiens]

Protein Classification

MFS transporter( domain architecture ID 999995)

major facilitator superfamily (MFS) transporter facilitates the transport across cytoplasmic or internal membranes of one or more from a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides

CATH:  1.20.1250.20
Gene Ontology:  GO:0022857|GO:0055085
PubMed:  26758938|26098515
SCOP:  3000310
TCDB:  2.A.1

Graphical summary

 Zoom to residue level

show extra options »

Show site features     Horizontal zoom: ×

List of domain hits

 Name Accession Description Interval E-value
MFS super family cl28910
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 23-433 0e+00

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


The actual alignment was detected with superfamily member cd17432:

Pssm-ID: 475125 [Multi-domain]  Cd Length: 452  Bit Score: 603.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  23 TICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRK 102
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 103 KSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQV 182
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 183 VGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQG 262
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 263 CRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSVAGVDE- 341
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERl 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 342 --------GWGVQAGLTSTSPPPRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALM 413
Cdd:cd17432  321 grrplligGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400

                        410       420
                 ....*....|....*....|.
gi 544583512 414 WIMLILVGLGFPFIMV-LGSF 433
Cdd:cd17432  401 WLSNFLVGLLFPFIQEgLGAY 421
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 23-433 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 603.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  23 TICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRK 102
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 103 KSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQV 182
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 183 VGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQG 262
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 263 CRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSVAGVDE- 341
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERl 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 342 --------GWGVQAGLTSTSPPPRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALM 413
Cdd:cd17432  321 grrplligGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400

                        410       420
                 ....*....|....*....|.
gi 544583512 414 WIMLILVGLGFPFIMV-LGSF 433
Cdd:cd17432  401 WLSNFLVGLLFPFIQEgLGAY 421
Sugar_tr pfam00083
Sugar (and other) transporter;
22-428 9.96e-66

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 220.22  E-value: 9.96e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   22 LTICAAgIGGtFQFGYNLSIINAPTLHIQEFTNETWQARTGeplPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGR 101
Cdd:pfam00083   1 VALVAA-LGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVS---SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  102 KKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQ 181
Cdd:pfam00083  76 KKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  182 VVGLR-ELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIdCGDTEACLAALRRLRGSGDLAGELEELEEERAAC 260
Cdd:pfam00083 156 IFGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVE-KGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  261 QGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAkiQYAIIGTGSCELLTAVVSVAGVD 340
Cdd:pfam00083 235 QEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS--FLVTIIVGVVNFVFTFIAIFLVD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  341 ---------EGWGVQAG-LTSTSPPPRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCG 410
Cdd:pfam00083 313 rfgrrplllLGAAGMAIcFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALAT 392

                         410
                  ....*....|....*...
gi 544583512  411 ALMWIMLILVGLGFPFIM 428
Cdd:pfam00083 393 AANWLANFLIGFLFPIIT 410
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 2-428 4.35e-54

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 189.86  E-value: 4.35e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512    2 EDELEPSLRPRTQI--QGRILLLTICAAgIGGtFQFGYNLSIINAptlhIQEFTNETWQArtGEPLPDHLVLLMWSLIVS 79
Cdd:TIGR00879   7 ADASELLVTPAGLGstYWKVALLSLIAA-IGG-LMFGYDTGVIGG----ALALPAFEFKF--TSANSDSYSSSLWGLVVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   80 LYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPK 159
Cdd:TIGR00879  79 IFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  160 ELRGAVAMSSAIFTALGIVMGQVVG-LRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDcGDTEACLAALR 238
Cdd:TIGR00879 159 ALRGALTSLYQLAITFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GRVEEARKSLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  239 RLRGSG--DLAGELEELEEERAACQGCRARRP--WELFQ-HRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVP 313
Cdd:TIGR00879 238 RLRGTSgeDKELLDELELIDIKRSIEKRSVQPswGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  314 EAKIQYAIIGTGSCELLTAVVSVAGVD---------EGWGVQA-------GLTSTSPPPRPRQSSfpwtlYLAMACIFAF 377
Cdd:TIGR00879 318 TDHAFLVSIIVGAVNFAFTFVAIFLVDrfgrrplllIGAAGMAiclfvlgILGASFVTGSSKSSG-----NVAIVFILLF 392

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 544583512  378 ILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIM 428
Cdd:TIGR00879 393 IAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTML 443
xylE PRK10077
D-xylose transporter XylE; Provisional
 27-243 4.95e-11

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 65.10  E-value: 4.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  27 AGIGGTFqFGYNLSIINAptlhiqefTNETWQARTGEP--LPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKS 104
Cdd:PRK10077  17 ATLGGLL-FGYDTAVISG--------TVESLNTVFVAPqnLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 105 LLVNNI-FVVSA----AILFGFSRK----AGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMssaiFTAL 175
Cdd:PRK10077  88 LKIAAVlFFISAlgsaWPEFGFTSIgpdnTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVS----FNQF 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 176 GIVMGQV----VGLRELLGGPQA------WPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEAcLAALRRLRGS 243
Cdd:PRK10077 164 AIIFGQLvvyfVNYFIARSGDASwlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQA-EGILRKIMGN 240
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 75-259 5.07e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 63.68  E-value: 5.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG0477   52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVVGLreLLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACL 234
Cdd:COG0477  129 ELFPARERGRALGLWGAAIGLGLALGPLLGG--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAAL 206

                        170       180
                 ....*....|....*....|....*
gi 544583512 235 AALRRLRGSGDLAGELEELEEERAA 259
Cdd:COG0477  207 LLAALALALLALLLLLLLLLLALLA 231
 
Name Accession Description Interval E-value
MFS_GLUT_Class2 cd17432
Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 23-433 0e+00

Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT5, also called Solute carrier family 2, facilitated glucose transporter member 5 (SLC2A5), is a well-established fructose transporter found in the small intestine. GLUT7 (or SLC2A7) is a high-affinity glucose and fructose transporter expressed in the small intestine and colon. GLUT9 (or SLC2A9) transports urate and fructose, and is most strongly expressed in the basolateral membranes of proximal renal tubular cells, liver and placenta. It may play a role in urate reabsorption by proximal tubules. GLUT11 (or SLC2A11) is a facilitative glucose transporter expressed in heart and skeletal muscle. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340990 [Multi-domain]  Cd Length: 452  Bit Score: 603.07  E-value: 0e+00
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  23 TICAAGIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRK 102
Cdd:cd17432    1 ATLAAAFGSSFQYGYNLSVVNSPTPYIQNFYNETWTERYGTPLEESTLTLLWSLTVSIFPLGGLFGSLLVGPLVIRLGRK 80

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 103 KSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQV 182
Cdd:cd17432   81 GTLLLNNIFAIVAAILMGLSKIAKSFEMIIVGRFLVGINAGISLNVVPMYLGESAPKNLRGAVGLVPAIFITLGILLGQV 160

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 183 VGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQG 262
Cdd:cd17432  161 LGLRELLGNEEGWPLLLALTGVPALLQLLTLPFFPESPRYLLIEKGDEEAARKALQRLRGKEDVDDEMEEMLEEQRAEKG 240

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 263 CRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSVAGVDE- 341
Cdd:cd17432  241 VGTVSVLELFRDRSVRWQLISIIVLMAGQQLCGINAIYFYADSIFLEAGIPEDKIQYVTVGTGACEVLATITCVLVIERl 320

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 342 --------GWGVQAGLTSTSPPPRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALM 413
Cdd:cd17432  321 grrplligGFGLMAVWCAVLTVALSLQNTVSWMPYLSIVCIFAYIASFGIGPAGVPFILTTEIFDQSSRPAAFMVAGSLN 400

                        410       420
                 ....*....|....*....|.
gi 544583512 414 WIMLILVGLGFPFIMV-LGSF 433
Cdd:cd17432  401 WLSNFLVGLLFPFIQEgLGAY 421
MFS_GLUT_Class1_2_like cd17357
Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This ...
 23-433 2.27e-89

Class 1 and Class 2 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; This subfamily includes Class 1 and Class 2 glucose transporters (GLUTs) including Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1, also called glucose transporter type 1 or GLUT1), SLC2A2-5 (GLUT2-5), SLC2A7 (GLUT7), SLC2A9 (GLUT9), SLC2A11 (GLUT11), SLC2A14 (GLUT14), and similar proteins. GLUTs are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-5 are the most thoroughly studied and are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340915 [Multi-domain]  Cd Length: 447  Bit Score: 281.84  E-value: 2.27e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  23 TICAAgIGGTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRK 102
Cdd:cd17357    1 AVIVA-FGGSFQFGYNIGVVNAPQEVFKEFINDTLVDRYGLNLSDSELDLLWSLIVSIFFIGGAIGSFISAFLANRFGRK 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 103 KSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQV 182
Cdd:cd17357   80 NGLLISNALLVVSSLLMFLSKSAKSPELLIFGRFLVGIACGLSTGFVPMYLQEISPSELRGALGSLTQIGVTLGILLGQV 159

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 183 VGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQG 262
Cdd:cd17357  160 FGLPSVLGTETLWPYLLFFPGIPALLQLAALPFFPESPKFLLISKGDEEEAEKSLKFLRGIEDDVDQELEEIKKESEQMG 239

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 263 CR-ARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSVAGVDE 341
Cdd:cd17357  240 DQkQVSLMQLLRDPSLRLPLLLVLVVSASQQFSGINAIFFYSTFIFENAGFSPQLAEWANLGIGIVNVLSTIVGPFLIEK 319

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 342 gWG-----------------VQAGLTSTsppprprQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPA 404
Cdd:cd17357  320 -VGrrplllislsvcavallLMSVFLFL-------SEQNSWMSYGCIVAIFLFIFFFAIGLGPIPWFIGAELFPQAPRSA 391

                        410       420
                 ....*....|....*....|....*....
gi 544583512 405 ACMVCGALMWIMLILVGLGFPFIMVLGSF 433
Cdd:cd17357  392 AQSLGSSVNWTSNFIVGMAFPPLQSIGGG 420
MFS_GLUT_Class1 cd17431
Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called ...
 31-427 4.00e-89

Class 1 Glucose transporters (GLUTs) of the Major Facilitator Superfamily; GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUTs 1-4 are well-established as glucose and/or fructose transporters in various tissues and cell types. GLUT1, also called solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1), displays broad substrate specificity and can transport a wide range of pentoses and hexoses including glucose, galactose, mannose, and glucosamine. It is found in the brain, erythrocytes, and in many fetal tissues. GLUT2 (or SLC2A2) is found in the liver, islet of Langerhans, intestine, and kidney, and is the isoform that likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by beta cells. GLUT3 (or SLC2A3) is found in the brain and can mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and dehydroascorbate. GLUT4 (or SLC2A4) is an insulin-regulated facilitative glucose transporter found in adipose tissues, and in skeletal and cardiac muscle. GLUT14 (or SLC2A14) is an orphan transporter expressed mainly in the testis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340989 [Multi-domain]  Cd Length: 445  Bit Score: 281.15  E-value: 4.00e-89
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  31 GTFQFGYNLSIINAPTLHIQEFTNETWQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNI 110
Cdd:cd17431    9 GSLQFGYNTGVINAPQKVIEEFYNKTLGDRYGEPISPETLTTLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLYNNL 88

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 111 FVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLG 190
Cdd:cd17431   89 LAFAGAALMGLSKLAKSYEMLILGRFIIGLYCGLTTGLVPMYIGEISPTALRGALGTLHQLGIVVGILISQIFGLEFILG 168

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 191 GPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACLAALRRLRGSGDLAGELEELEEERAACQGCRARRPWE 270
Cdd:cd17431  169 TEELWPLLLGFTIVPAILQLALLPFCPESPRYLLINRNEEEEAKSVLKKLRGTTDVSEDIQEMKEESRQMMREKKVTILE 248

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 271 LFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKiqYAIIGTGSCELLTAVVSVAGVDE--------- 341
Cdd:cd17431  249 LFRSSSYRQPIIIAIVLQLSQQLSGINAVFYYSTSIFEKAGVQQPV--YATIGAGVVNTIFTVVSLFLVERagrrtlhli 326

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 342 ---GWGVQAGLTSTSpppRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLI 418
Cdd:cd17431  327 glgGMAICAILMTIA---LLLLEGYPWMSYVSIVAIFGFVAFFEIGPGPIPWFIVAELFSQGPRPAAMAVAGFSNWTSNF 403


                 ....*....
gi 544583512 419 LVGLGFPFI 427
Cdd:cd17431  404 IVGMCFQYI 412
Sugar_tr pfam00083
Sugar (and other) transporter;
22-428 9.96e-66

Sugar (and other) transporter;


Pssm-ID: 395036 [Multi-domain]  Cd Length: 452  Bit Score: 220.22  E-value: 9.96e-66
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   22 LTICAAgIGGtFQFGYNLSIINAPTLHIQEFTNETWQARTGeplPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGR 101
Cdd:pfam00083   1 VALVAA-LGG-FLFGYDTGVIGAFLTLIDFFKNFGLSKSVS---SLAALSVLSGLIVSIFSVGCFIGSLFAGKLGDRFGR 75

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  102 KKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQ 181
Cdd:pfam00083  76 KKSLLIANVLFVIGAVLQGAAKGKWSVYQLIVGRVLVGIGVGGASVLAPMYISEIAPKKLRGALGSLYQLAITFGILLAY 155

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  182 VVGLR-ELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIdCGDTEACLAALRRLRGSGDLAGELEELEEERAAC 260
Cdd:pfam00083 156 IFGLGlNKTSNSDGWRIPLGLQLVPALLLIIGLLFLPESPRWLVE-KGRLEEAREVLAKLRGVPDVDRELDEIKDSLEAG 234

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  261 QGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAkiQYAIIGTGSCELLTAVVSVAGVD 340
Cdd:pfam00083 235 QEAEKASWKELFSTKTRRQRLLIGVMLQIFQQLTGINAIFYYSTTIFENLGLSDS--FLVTIIVGVVNFVFTFIAIFLVD 312

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  341 ---------EGWGVQAG-LTSTSPPPRPRQSSFPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCG 410
Cdd:pfam00083 313 rfgrrplllLGAAGMAIcFVILGIVALLGVSKSDWAGIVAIVFIALFIAFFAMGWGPVPWVIVSELFPLSVRSKAMALAT 392

                         410
                  ....*....|....*...
gi 544583512  411 ALMWIMLILVGLGFPFIM 428
Cdd:pfam00083 393 AANWLANFLIGFLFPIIT 410
SP TIGR00879
MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of ...
 2-428 4.35e-54

MFS transporter, sugar porter (SP) family; This model represent the sugar porter subfamily of the major facilitator superfamily (pfam00083) [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273317 [Multi-domain]  Cd Length: 481  Bit Score: 189.86  E-value: 4.35e-54
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512    2 EDELEPSLRPRTQI--QGRILLLTICAAgIGGtFQFGYNLSIINAptlhIQEFTNETWQArtGEPLPDHLVLLMWSLIVS 79
Cdd:TIGR00879   7 ADASELLVTPAGLGstYWKVALLSLIAA-IGG-LMFGYDTGVIGG----ALALPAFEFKF--TSANSDSYSSSLWGLVVS 78

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   80 LYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPK 159
Cdd:TIGR00879  79 IFLVGGFIGALFAGWLSDRFGRKKSLLIIALLFVIGAILMGLAAFALSVEMLIVGRVLLGIGVGIASALVPMYLSEIAPK 158

                         170       180       190       200       210       220       230       240
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  160 ELRGAVAMSSAIFTALGIVMGQVVG-LRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDcGDTEACLAALR 238
Cdd:TIGR00879 159 ALRGALTSLYQLAITFGILVAYGFGsGKVSLNNTLGWRIPLGLQLIPAGLLFLGLFFLPESPRWLVGK-GRVEEARKSLA 237

                         250       260       270       280       290       300       310       320
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  239 RLRGSG--DLAGELEELEEERAACQGCRARRP--WELFQ-HRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVP 313
Cdd:TIGR00879 238 RLRGTSgeDKELLDELELIDIKRSIEKRSVQPswGSLFSsTRRIRRRLFLGVVLQWFQQFTGINAIMYYSPTIFENAGVS 317

                         330       340       350       360       370       380       390       400
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  314 EAKIQYAIIGTGSCELLTAVVSVAGVD---------EGWGVQA-------GLTSTSPPPRPRQSSfpwtlYLAMACIFAF 377
Cdd:TIGR00879 318 TDHAFLVSIIVGAVNFAFTFVAIFLVDrfgrrplllIGAAGMAiclfvlgILGASFVTGSSKSSG-----NVAIVFILLF 392

                         410       420       430       440       450
                  ....*....|....*....|....*....|....*....|....*....|.
gi 544583512  378 ILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIMLILVGLGFPFIM 428
Cdd:TIGR00879 393 IAFFAMGWGPVPWVIVSEIFPLSLRPKGISIAVAANWLANFIVGFLFPTML 443
MFS_GLUT_like cd17315
Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator ...
 26-429 1.14e-39

Glucose transporters (GLUTs) and other similar sugar transporters of the Major Facilitator Superfamily; This family is composed of glucose transporters (GLUTs) and other sugar transporters including fungal hexose transporters (HXT), bacterial xylose transporter (XylE), plant sugar transport proteins (STP) and polyol transporters (PLT), H(+)-myo-inositol cotransporter (HMIT), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. The GLUT-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340873 [Multi-domain]  Cd Length: 365  Bit Score: 147.72  E-value: 1.14e-39
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  26 AAGIGGtFQFGYNLSIINAPTLHIQEFTNEtwqartgeplpdHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSL 105
Cdd:cd17315    1 VAALGG-LLFGYDLGVINGALLYIAKDLGF------------GLSTSLQGLVVSSLLLGAAIGSLFGGPLADRFGRRKSL 67

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 106 LVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGL 185
Cdd:cd17315   68 LIAAVLYVIGALLSALAP---NVWVLIVGRFLLGLGVGLASVLVPLYISEIAPAKIRGALGTLNQLMITFGILLAYLLGL 144

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 186 RELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRyLLIDCGdteaclaalrrlrgsgdlageleeleeeraacqgcra 265
Cdd:cd17315  145 ALSLSPPGWWRLMFALAAVPALLQLLLMFFLPESRA-LLVGVG------------------------------------- 186

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 266 rrpWELFQhralrrqvtslvvlgsamELCGNDSVYAYASSVFRKAGVPEAKIqYAIIGTGSCELLTAVVSVAGVD----- 340
Cdd:cd17315  187 ---LQLLQ------------------QLTGINAVMYYAPTIFKSAGGGTASI-LASIIVGVVNLLATLVAIRLVDkvgrr 244

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 341 ----EGW-GVQAGLTSTSPPPRPRQSSfPWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWI 415
Cdd:cd17315  245 plllIGFaGMAASLLLLAIAFLLPALA-KAAGWLALLGILLYIAAFAMGAGPVPWLLLSEIFPLRIRGKGMAIATLVNWI 323

                        410
                 ....*....|....
gi 544583512 416 MLILVGLGFPFIMV 429
Cdd:cd17315  324 FNFIVGLTFLIMVS 337
MFS_GLUT6_8_Class3_like cd17358
Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major ...
 21-428 1.38e-38

Glucose transporter (GLUT) types 6 and 8, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 6 (GLUT6), GLUT8, plant early dehydration-induced gene ERD6-like proteins, and similar insect proteins including facilitated trehalose transporter Tret1-1. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). Insect Tret1-1 is a low-capacity facilitative transporter for trehalose that mediates the transport of trehalose synthesized in the fat body and the incorporation of trehalose into other tissues that require a carbon source. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340916 [Multi-domain]  Cd Length: 436  Bit Score: 146.57  E-value: 1.38e-38
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  21 LLTICAAGIGgTFQFGYNLSIiNAPTLHiqeftnetwQARTGEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLG 100
Cdd:cd17358    1 LLATFVANLG-SFSFGIAVGW-SSPALP---------SLMSDNSLSLPLTVAQFSWFGSLLTLGALIGALLSGKLADRIG 69

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 101 RKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMG 180
Cdd:cd17358   70 RKRTLLISAIPCILGWLLIAFAK---DVWMLYLGRFLAGFGGGAASVVVPVYIAEIAPKNVRGALGSLNQLLVNIGILLG 146

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 181 QVVGLRellggpQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDcGDTEACLAALRRLRG-----SGDLAGELEELEE 255
Cdd:cd17358  147 YVLGSF------LPWRTLALIGAIPPVVFLILLFFIPESPRWLAKK-GREEEAEKSLQFLRGkdadiSKEAAEIQEELAE 219

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 256 ERAACQgcraRRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVP-EAKIQYAIIGTGscELLTAVV 334
Cdd:cd17358  220 LEKEAK----ESSFSDLFQRKYLKPLVIGLGLMLFQQLSGINAVIFYASSIFDEAGSGlDPNTATIIIGVV--QVVGTLV 293

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 335 SVAGVDEgWGVQ-AGLTSTS---------------PPPRPRQSSFPWtlyLAMACIFAFILSFGIGPAGVTGILATELFD 398
Cdd:cd17358  294 ATLLVDR-LGRRpLLLVSAIgmgigllalglyfylQEHGALLSSVSW---LPLVGLVIYIISFSIGLGPLPWVIMSEIFP 369

                        410       420       430
                 ....*....|....*....|....*....|
gi 544583512 399 QMARPAACMVCGALMWIMLILVGLGFPFIM 428
Cdd:cd17358  370 AKIKGLAGSLVTLVNWLFAFIVTKTFPFLT 399
MFS_XylE_like cd17359
D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This ...
 25-428 4.90e-30

D-xylose-proton symporter and similar transporters of the Major Facilitator Superfamily; This subfamily includes bacterial transporters such as D-xylose-proton symporter (XylE or XylT), arabinose-proton symporter (AraE), galactose-proton symporter (GalP), major myo-inositol transporter IolT, glucose transport protein, putative metabolite transport proteins YfiG, YncC, and YwtG, and similar proteins. The symporters XylE, AraE, and GalP facilitate the uptake of D-xylose, arabinose, and galactose, respectively, across the boundary membrane with the concomitant transport of protons into the cell. IolT is involved in polyol metabolism and myo-inositol degradation into acetyl-CoA. The XylE-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340917 [Multi-domain]  Cd Length: 383  Bit Score: 121.14  E-value: 4.90e-30
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  25 CAAGIGGtFQFGYNLSIINAPTLHIQEftnetwqartgeplPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKS 104
Cdd:cd17359    4 LVAALGG-LLFGYDTGVINGALPFLQT--------------DFNLTPFLEGLVVSSALLGAAIGALFAGRLADRFGRRKT 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 105 LLVNNIFVVSAAILFGFSrkaGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVV- 183
Cdd:cd17359   69 LLISAVLFFISALGSAFS---PNFTIFIIARIIGGLAVGGASALVPMYIAEVAPAEIRGRLVSLNQLMIVFGQLLAYIVn 145

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 184 -----GLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLidcgdteaclaalrrlrgsgdlageleeleeera 258
Cdd:cd17359  146 ylianAGGADWLGAEGWRWMLGLEAIPAILFLLGMLFIPESPRWLV---------------------------------- 191

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 259 acqgcrarrpwelfqhRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAKIQYAIIGTGSCELLTAVVSVAG 338
Cdd:cd17359  192 ----------------SKGKPILIIGIGLAIFQQFVGINVIFYYGPEIFQNAGFSENAALLQTIGIGVVNVIFTIIAILL 255

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 339 VDE------------GWGVQAGLTSTSPPPRPRQSSFPWtlyLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAAC 406
Cdd:cd17359  256 VDKvgrkpllligsiGMAISLLLIGTAFYFAPGSQASGI---VALVLILLFVAFFAMSWGPVTWVLLSEIFPNRIRGLAM 332

                        410       420
                 ....*....|....*....|..
gi 544583512 407 MVCGALMWIMLILVGLGFPFIM 428
Cdd:cd17359  333 GIAVFFLWIANFLVSLTFPILL 354
MFS_HMIT_like cd17360
H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; ...
 26-228 7.49e-24

H(+)-myo-inositol cotransporter and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of myo-inositol/inositol transporters and similar transporters from vertebrates, plant, and fungi. The human protein is called H(+)-myo-inositol cotransporter/Proton myo-inositol cotransporter (HMIT), or H(+)-myo-inositol symporter, or Solute carrier family 2 member 13 (SLC2A13). HMIT is classified as a Class 3 GLUT (glucose transporter) based on sequence similarity with GLUTs, but it does not transport glucose. It specifically transports myo-inositol and is expressed predominantly in the brain, with high expression in the hippocampus, hypothalamus, cerebellum and brainstem. HMIT may be involved in regulating processes that require high levels of myo-inositol or its phosphorylated derivatives, such as membrane recycling, growth cone dynamics, and synaptic vesicle exocytosis. Arabidopsis Inositol transporter 4 (AtINT4) mediates high-affinity H+ symport of myo-inositol across the plasma membrane. The HMIT-like subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340918 [Multi-domain]  Cd Length: 362  Bit Score: 103.12  E-value: 7.49e-24
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  26 AAGIGGtFQFGYNLSIINAPTLHIQEftnetwqartgEPLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSL 105
Cdd:cd17360    1 FAGIGG-FLFGYDTGVISGALLYIKD-----------DLGEVVLSTGWQELIVSSTVAGAAVGAAIGGWLNDRFGRRPCI 68

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 106 LVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFtalgIVMGQVVGl 185
Cdd:cd17360   69 LLADALFTIGAIVMAAAP---NKEVLIVGRVLVGLGVGIASMTVPLYIAEAAPPRIRGRLVTINVLF----ITGGQFVA- 140

                        170       180       190       200       210
                 ....*....|....*....|....*....|....*....|....*....|....
gi 544583512 186 rELLGG-----PQAWPLLLASCLVPGALQLASLPLLPESPRY------LLIDCG 228
Cdd:cd17360  141 -YVINGafsylPGGWRWMLGLAAVPAVLQFIGLLFLPESPRWpstrraLIVGCG 193
MFS_HXT cd17356
Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and ...
 75-225 2.96e-20

Fungal Hexose transporter subfamily of the Major Facilitator Superfamily of transporters and similar proteins; The fungal hexose transporter (HXT) subfamily is comprised of functionally redundant proteins that function mainly in the transport of glucose, as well as other sugars such as galactose and fructose. Saccharomyces cerevisiae has 20 genes that encode proteins in this family (HXT1 to HXT17, GAL2, SNF3, and RGT2). Seven of these (HXT1-7) encode functional glucose transporters. Gal2p is a galactose transporter, while Rgt2p and Snf3p act as cell surface glucose receptors that initiate signal transduction in response to glucose, functioning in an induction pathway responsible for glucose uptake. Rgt2p is activated by high levels of glucose and stimulates expression of low affinity glucose transporters such as Hxt1p and Hxt3p, while Snf3p generates a glucose signal in response to low levels of glucose, stimulating the expression of high affinity glucose transporters such as Hxt2p and Hxt4p. Schizosaccharomyces pombe contains eight GHT genes (GHT1-8) belonging to this family. Ght1, Ght2, and Ght5 are high-affinity glucose transporters; Ght3 is a high-affinity gluconate transporter; and Ght6 high-affinity fructose transporter. The substrate specificities for Ght4, Ght7, and Ght8 remain undetermined. The HXT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340914 [Multi-domain]  Cd Length: 403  Bit Score: 93.08  E-value: 2.96e-20
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17356   48 GLIVSIVNLGSFFGALISSFLSDRIGRKKSIQIGCVIYIIGAIIQVAA--IGKWYQLIVGRIIAGLGVGFASVLVPVYQS 125

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVV--GLReLLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLI 225
Cdd:cd17356  126 EVAPKHIRGTLVSLYQLAITIGILVAYCInyGTH-KLDGSAQWRIPLGLQIVWGLLLLIGMFFLPESPRWLYR 197
MFS_GLUT10_12_Class3_like cd17362
Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the ...
 35-425 1.05e-19

Glucose transporter (GLUT) types 10 and 12, Class 3 GLUTs, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of glucose transporter type 10, GLUT12, plant polyol transporters (PLTs), and similar proteins. GLUTs, also called Solute carrier family 2, facilitated glucose transporters (SLC2A), are a family of proteins that facilitate the transport of hexoses such as glucose and fructose. There are fourteen GLUTs found in humans; they display different substrate specificities and tissue expression. They have been categorized into three classes based on sequence similarity: Class 1 (GLUTs 1-4, 14); Class 2 (GLUTs 5, 7, 9, and 11); and Class 3 (GLUTs 6, 8, 10, 12, and HMIT). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340920 [Multi-domain]  Cd Length: 389  Bit Score: 91.26  E-value: 1.05e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  35 FGYNLSIINAPTLHIQ--EFTNETWQArtgeplpdhLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFV 112
Cdd:cd17362    9 FGYDIGATSGALLSITspALSGTDWYN---------LSSLQSGLVVSGSLLGALLGSLVAGALIDRLGRRKELILAALLY 79

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 113 VSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGlRELLGGP 192
Cdd:cd17362   80 LVGSLVTGL---APSYPVLLVGRLIYGVGIGLAMHAAPVYIAETSPSHIRGLLVSLKELFIVLGILLGYVSG-YAFADVV 155

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 193 QAWPLLLASCLVPGALQLASLPLLPESPRYLlidcgdteacLAALRRLRGSGDLAgeleeleeeraacqgcrarrpweLF 272
Cdd:cd17362  156 GGWRYMYGLAAPPALLLGIGMWFLPPSPRWQ----------GNYRKPLIIGLGLV-----------------------LF 202

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 273 QHralrrqvtslvvlgsameLCGNDSVYAYASSVFRKAGVPEA-KIQYAIIGTGSCELLTAVVSVAGVDE---------G 342
Cdd:cd17362  203 QQ------------------ITGQPSVLYYAATIFKSAGFSAAsDATLVSVGLGVFKLLMTIVAVLLVDKlgrrplllgG 264

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 343 WGVQA------GLTSTSPPPRPRqssfpWTLYLAMACIFAFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIM 416
Cdd:cd17362  265 VSGMVvslfllAAYNLFVQMGPA-----GLAWLSLVALLLYVGAYQISFGPISWLMVSEIFPLRVRGRAIALAVLVNFGS 339


                 ....*....
gi 544583512 417 LILVGLGFP 425
Cdd:cd17362  340 NALVSLAFL 348
MFS_GLUT8_Class3 cd17433
Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 79-428 1.37e-17

Glucose transporter type 8, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 8 (GLUT8) is also called Solute carrier family 2, facilitated glucose transporter member 8 (SLC2A8) or glucose transporter type X1 (GLUTX1). It is classified as a Class 3 GLUT protein and is an insulin-regulated facilitative glucose transporter predominantly expressed in testis and brain. It can also transport fructose and galactose. SLC2A8 knockout mice were viable, developed normally, and display only a very mild phenotype, including mild alterations in the brain (increased proliferation of hippocampal neurons), heart (impaired transmission of electrical wave through the atrium), and sperm cells (reduced number of motile sperm cells). GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340991 [Multi-domain]  Cd Length: 416  Bit Score: 84.93  E-value: 1.37e-17
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  79 SLYPLGGLFGALLAGPLAITLGRKKSLLVnnifvVSAAILFGFS--RKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGES 156
Cdd:cd17433   48 SVVTLGAAAGGVLGGWIVDRAGRKLSLML-----CSVPFIAGFTviTAAQNVWMLYVGRLLTGLASGVTSLVVPVYISEI 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 157 APKELRGAVAMSSAIFTALGIVMGQVVGLRellggpQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEAcLAA 236
Cdd:cd17433  123 AHPRVRGTLGSCVQLMVVIGIMGAYLAGLV------LDWRWLAVLGSIPPTLMLLLMCFMPETPRFLLTQHRRQEA-MAA 195

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 237 LRRLRGSGdlAGELEELEEERAACQGCRARRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVPEAK 316
Cdd:cd17433  196 LRFLRGPD--QGWEWECIGIEQSFHLEEQSFSLALLKQPGIYKPLIIGVSLMAFQQLTGINAVMFYAETIFEEAKFKDSS 273

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 317 IQYAIIGTGSCeLLTAVVSVagVDEGWGVQAGLTSTSPPPRPRQSSFPWtlyLAMACIFAFILSFGIGPAGVTGILATEL 396
Cdd:cd17433  274 VASVIVAAIQV-LFTAVAAL--IMDRAGRKVLLVLSGVVMVFSTAAFGW---LAVGSMGFFIAGFAVGWGPIPWLVMSEI 347

                        330       340       350
                 ....*....|....*....|....*....|..
gi 544583512 397 FDQMARPAACMVCGALMWIMLILVGLGFPFIM 428
Cdd:cd17433  348 FPLHVRGVASGICVLTNWLMAFLVTKEFSSLM 379
MFS_STP cd17361
Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; ...
 79-220 1.18e-15

Plant Sugar transport protein subfamily of the Major Facilitator Superfamily of transporters; The plant Sugar transport protein (STP) subfamily includes STP1-STP14; they are also called hexose transporters. They mediate the active uptake of hexoses such as glucose, 3-O-methylglucose, fructose, xylose, mannose, galactose, fucose, 2-deoxyglucose and arabinose, by sugar/hydrogen symport. Several STP family transporters are expressed in a tissue-specific manner, or at specific developmental stages. STP1 is the member with the highest expression level of all members and high expression is detected in photosynthetic tissues, such as leaves and stems, while roots, siliques, and flowers show lower expression levels. It plays a major role in the uptake and response of Arabidopsis seeds and seedlings to sugars. The STP subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340919 [Multi-domain]  Cd Length: 390  Bit Score: 78.83  E-value: 1.18e-15
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  79 SLYpLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGsfeMIMLGRLLVGVNAGVSMNIQPMYLGESAP 158
Cdd:cd17361   59 SLY-LAGLVASLLASYVTRKWGRKPSMLIGGVLFLVGAALNAAAQNIA---MLIVGRILLGFGVGFGNQAVPLYLSEMAP 134

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544583512 159 KELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESP 220
Cdd:cd17361  135 AKLRGALNIGFQLAITIGILIANLINYGTSKIKPNGWRLSLGLAAVPALILLLGSLFLPETP 196
MFS_PLT cd17437
Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The ...
 86-424 2.78e-14

Plant Polyol transporter family of the Major Facilitator Superfamily of transporters; The plant Polyol transporter (PLT) subfamily includes PLT1-6 from Arabidopsis thaliana and similar transporters. The best characterized member of the group is Polyol transporter 5, also called Sugar-proton symporter PLT5, which mediates the H+-symport of numerous substrates including linear polyols (such as sorbitol, xylitol, erythritol or glycerol), cyclic polyol myo-inositol, and different hexoses, pentoses (including ribose), tetroses, and sugar alcohols. It functions to transport a wide range of substrates into specific sink tissues in the plant. The PLT subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340995 [Multi-domain]  Cd Length: 387  Bit Score: 74.74  E-value: 2.78e-14
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  86 LFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAV 165
Cdd:cd17437   46 LVGSLAAGRTSDWIGRRYTIALAALIFFVGALLMGV---APNYPVLMVGRFVAGIGVGFALMIAPVYTAEVAPASSRGFL 122

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 166 AMSSAIFTALGIVMGQVV-----GLRELLGgpqaWPLLLASCLVPGALQLASLPLLPESPRYLlidcgdteaclaalrrl 240
Cdd:cd17437  123 TSFPEIFINIGILLGYVSnyafsGLPLHVG----WRLMLGVGAVPSLFLAIGVLAMPESPRWT----------------- 181

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 241 rgsgdlageleeleeeraacqgcrarrpwelfqhRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGV-PEAKIQY 319
Cdd:cd17437  182 ----------------------------------PAVRRMLIAALGIHFFQQASGIDAVVLYSPRIFKKAGIkSKDKLLL 227

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 320 AIIGTGSCELLTAVVSVAGVDE----------GWGVQAGLTSTSPP---PRPRQSSFPWTLYLAMACIFAFILSFGIGPA 386
Cdd:cd17437  228 ATVAVGVTKTLFILVATFLLDKvgrrpllltsTGGMTLSLTALATSltfIDRNGGGLTWALVLAITAVCSFVAFFSIGAG 307

                        330       340       350
                 ....*....|....*....|....*....|....*...
gi 544583512 387 GVTGILATELFDQMARPAACMVCGALMWIMLILVGLGF 424
Cdd:cd17437  308 PITWVYSSEIFPLRLRAQGASLGVVVNRLMSGTVSMTF 345
xylE PRK10077
D-xylose transporter XylE; Provisional
 27-243 4.95e-11

D-xylose transporter XylE; Provisional


Pssm-ID: 182225 [Multi-domain]  Cd Length: 479  Bit Score: 65.10  E-value: 4.95e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  27 AGIGGTFqFGYNLSIINAptlhiqefTNETWQARTGEP--LPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKS 104
Cdd:PRK10077  17 ATLGGLL-FGYDTAVISG--------TVESLNTVFVAPqnLSESAANSLLGFCVASALIGCIIGGALGGYCSNRFGRRDS 87

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 105 LLVNNI-FVVSA----AILFGFSRK----AGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMssaiFTAL 175
Cdd:PRK10077  88 LKIAAVlFFISAlgsaWPEFGFTSIgpdnTGYVPEFVIYRIIGGIGVGLASMLSPMYIAEIAPAHIRGKLVS----FNQF 163

                        170       180       190       200       210       220       230
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 176 GIVMGQV----VGLRELLGGPQA------WPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEAcLAALRRLRGS 243
Cdd:PRK10077 164 AIIFGQLvvyfVNYFIARSGDASwlntdgWRYMFASEAIPALLFLMLLYFVPETPRYLMSRGKQEQA-EGILRKIMGN 240
ProP COG0477
MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and ...
 75-259 5.07e-11

MFS family permease, includes anhydromuropeptide permease AmpG [Carbohydrate transport and metabolism, Amino acid transport and metabolism, Inorganic ion transport and metabolism, General function prediction only];


Pssm-ID: 440245 [Multi-domain]  Cd Length: 295  Bit Score: 63.68  E-value: 5.07e-11
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG0477   52 GWIVSAYLLGRAIGLLLFGRLGDRYGRKRVLLIGLLLFGLASLLCGL---APSPELLIAARALQGIGAGGLMPGALALIA 128

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVVGLreLLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEACL 234
Cdd:COG0477  129 ELFPARERGRALGLWGAAIGLGLALGPLLGG--LLVAALGWRWIFLINAPLGLLALVLRLRLPESRGLLLALLALALAAL 206

                        170       180
                 ....*....|....*....|....*
gi 544583512 235 AALRRLRGSGDLAGELEELEEERAA 259
Cdd:COG0477  207 LLAALALALLALLLLLLLLLLALLA 231
MFS cd06174
Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse ...
 68-221 1.05e-10

Major Facilitator Superfamily; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of substrates including ions, sugar phosphates, drugs, neurotransmitters, nucleosides, amino acids, and peptides. They do so using the electrochemical potential of the transported substrates. Uniporters transport a single substrate, while symporters and antiporters transport two substrates in the same or in opposite directions, respectively, across membranes. MFS proteins are typically 400 to 600 amino acids in length, and the majority contain 12 transmembrane alpha helices (TMs) connected by hydrophilic loops. The N- and C-terminal halves of these proteins display weak similarity and may be the result of a gene duplication/fusion event. Based on kinetic studies and the structures of a few bacterial superfamily members, GlpT (glycerol-3-phosphate transporter), LacY (lactose permease), and EmrD (multidrug transporter), MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement. Bacterial members function primarily for nutrient uptake, and as drug-efflux pumps to confer antibiotic resistance. Some MFS proteins have medical significance in humans such as the glucose transporter Glut4, which is impaired in type II diabetes, and glucose-6-phosphate transporter (G6PT), which causes glycogen storage disease when mutated.


Pssm-ID: 349949 [Multi-domain]  Cd Length: 378  Bit Score: 63.60  E-value: 1.05e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  68 HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMN 147
Cdd:cd06174   27 GLSASQLGLLFALFSLGYALLQPLAGLLADRFGRRPVLLLGLLLFALGALLFAF---APSFWLLLLGRFLLGLGSGLIDP 103

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544583512 148 IQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPR 221
Cdd:cd06174  104 AVLALIADLFPERERGRALGLLQAFGSVGGILGPLLGGILASSLGFGWRAVFLIAAALALLAAILLLLVVPDPP 177
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
75-221 1.26e-10

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 63.07  E-value: 1.26e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG2814   48 GLVVTAYLLGAALGAPLAGRLADRFGRRRVLLLGLLLFALGSLLCAL---APSLWLLLAARFLQGLGAGALFPAALALIA 124

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVVGLreLLGGPQAWPLLLASCLVPGALQL-ASLPLLPESPR 221
Cdd:COG2814  125 DLVPPERRGRALGLLGAGLGLGPALGPLLGG--LLADLFGWRWVFLVNAVLALLALlLLLRLLPESRP 190
MFS_GLUT12_Class3 cd17435
Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 22-225 2.39e-10

Glucose transporter type 12 (GLUT12), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 12 (GLUT12) is also called Solute carrier family 2, facilitated glucose transporter member 12 (SLC2A12). It is a facilitative glucose transporter, classified as a Class 3 GLUT, and is expressed in the heart, skeletal muscle, prostate, and small intestine, and is highly upregulated in breast ductal cell carcinoma. It plays a role as a secondary insulin-sensitive glucose transporter in insulin-dependent tissues. The GLUT12 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340993 [Multi-domain]  Cd Length: 376  Bit Score: 62.51  E-value: 2.39e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  22 LTICAAGIGGTFqFGYNLSIINAPTLHIQEFTNETWQARtgeplpdhlvllmwSLIVSLYPLGGLFGALLAGPLAITLGR 101
Cdd:cd17435    1 LSSVTAAVSGLL-VGYELGIISGALLQLRTLLALSCHEQ--------------EMVVSSLLIGALLASLTGGVLIDRYGR 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 102 KKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQ 181
Cdd:cd17435   66 RTAIILTSCLLVLGSLLLVCSV---SYTVLIVGRIAIGVSISLSSIATCVYIAEIAPQHRRGLLVSLNELMIVIGILLAY 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 544583512 182 VVGLrELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLI 225
Cdd:cd17435  143 ISNY-AFANVSNGWKYMFGLVIPLAALQAIAMYFLPPSPRFLVM 185
MFS_GLUT6_Class3 cd17434
Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 27-431 2.48e-10

Glucose transporter type 6, a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 6 (GLUT6) is also called Solute carrier family 2, facilitated glucose transporter member 6 (SLC2A6). It is classified as a Class 3 GLUT protein, and is a facilitative glucose transporter that binds cytochalasin B with low affinity. It is found in the brain, spleen, and leucocytes. GLUT6 may function in oxalate secretion. SLC2A6 has been identified as an oxalate nephrolithiasis gene in mice; its deletion causes spontaneous calcium oxalate nephrolithiasis in the setting of hyperoxalaemia, hyperoxaluria, and nephrocalcinosis. GLUT proteins are comprised of about 500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 transmembrane segments. They belong to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340992 [Multi-domain]  Cd Length: 417  Bit Score: 62.54  E-value: 2.48e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  27 AGIGGTFQFGYNLSiinaptlhiqeFTNETWQARTGEPLPD-HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSL 105
Cdd:cd17434    6 SAVLGNFSFGYALV-----------YTSPVIPALEQGDDPRlHLNVHQISWFGSVFTLGAAAGGLSAMFLNDRLGRKLSI 74

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 106 LVNnifVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVGL 185
Cdd:cd17434   75 MFS---AVPSALGYLLMGSAQGIWMLLLGRFLTGFAGGITAASIPVYVSEISHPGVRGALGACPQIMAVFGSLALYALGL 151

                        170       180       190       200       210       220       230       240
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 186 reLLggpqAWPLLLASCLVPGALQLASLPLLPESPRYLLIDCGDTEAcLAALRRLRGSGDLAGELEELEEERAACQGcrA 265
Cdd:cd17434  152 --LL----PWRWLAVAGEVPVVIMILLLCFMPNSPRFLISKGKDEKA-LKALAWLRGPNTDYMTEFEQIKDNIRKQS--S 222

                        250       260       270       280       290       300       310       320
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 266 RRPWELFQHRALRRQVTSLVVLGSAMELCGNDSVYAYASSVFRKAGVP-EAKIQYAIIgtGSCELLTAVVSVAGVDEGwG 344
Cdd:cd17434  223 RLSWAELKTPSYYKPILIAVVMRFLQQLTGITPILVYLEPIFHLTAVIlEPKYDAALV--GAVRLLSVAIAASLMDKA-G 299

                        330       340       350       360       370       380       390       400
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 345 VQAGLTSTSppPRPRQSSFPWTLYLAMACIFaFILSFGIGPAGVTGILATELFDQMARPAACMVCGALMWIM-LILVGLG 423
Cdd:cd17434  300 RKILLFTSA--FLMFAANLSMGLIPLIAAML-FIMGYAMGWGPITWLLMSEILPLKARGVASGLCVVVSWITaFVLTQLF 376


                 ....*...
gi 544583512 424 FPFIMVLG 431
Cdd:cd17434  377 LPVVVTFG 384
synapt_SV2 TIGR01299
synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger ...
 83-224 1.12e-09

synaptic vesicle protein SV2; This model describes a tightly conserved subfamily of the larger family of sugar (and other) transporters described by pfam00083. Members of this subfamily include closely related forms SV2A and SV2B of synaptic vesicle protein from vertebrates and a more distantly related homolog (below trusted cutoff) from Drosophila melanogaster. Members are predicted to have two sets of six transmembrane helices.


Pssm-ID: 130366 [Multi-domain]  Cd Length: 742  Bit Score: 61.15  E-value: 1.12e-09
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   83 LGGLFGALLAGPLAITLGRKKSLL----VNNIFvvsaAILFGFSRKAGSFemiMLGRLLVGVNAGVSMNIQPMYLGESAP 158
Cdd:TIGR01299 213 LGMMVGAFFWGGLADKLGRKQCLLiclsVNGFF----AFFSSFVQGYGFF---LFCRLLSGFGIGGAIPIVFSYFAEFLA 285

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  159 KELRG----------------AVAMSSAIFTALG--IVMGQVVGLrellggpQAWPLLLASCLVPGALQLASLPLLPESP 220
Cdd:TIGR01299 286 QEKRGehlswlcmfwmiggiyAAAMAWAIIPHYGwsFQMGSAYQF-------HSWRVFVIVCAFPCVFAIGALTFMPESP 358


                  ....
gi 544583512  221 RYLL 224
Cdd:TIGR01299 359 RFFL 362
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 65-208 4.61e-09

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 58.38  E-value: 4.61e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  65 LPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSrkaGSFEMIMLGRLLVGVNAGV 144
Cdd:cd17316   29 FSLGLSLLQTGLLFAAGFLGRPIGALLFGYLGDRIGRKKALILTLLLFGLATLLIGLL---PTPILLLVLRFLQGIGIGG 105

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*.
gi 544583512 145 SMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQVVG--LRELLGGPQAWPLLLASCLVPGAL 208
Cdd:cd17316  106 EYPGASTYVAEFAPSKRRGFALGLLQSGWALGALLAALVAslLIPLLSGDWGWRILFLIGALPALL 171
2A0119 TIGR00898
cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]
 76-241 2.88e-08

cation transport protein; [Transport and binding proteins, Cations and iron carrying compounds]


Pssm-ID: 273328 [Multi-domain]  Cd Length: 505  Bit Score: 56.18  E-value: 2.88e-08
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   76 LIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGV-NAGVSMNIQPMYLg 154
Cdd:TIGR00898 131 LTQSCFFVGVLLGSFVFGYLSDRFGRKKVLLLSTLVTAVSGVLTAFSP---NYTVFLVFRLLVGMgIGGIWVQAVVLNT- 206

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  155 ESAPKELRGAVAMSSAIFTALGIVMgqVVGLRELLggpQAWPLLLASCLVPGALQLASLPLLPESPRYlLIDCGDTEACL 234
Cdd:TIGR00898 207 EFLPKKQRAIVGTLIQVFFSLGLVL--LPLVAYFI---PDWRWLQLAVSLPTFLFFLLSWFVPESPRW-LISQGRIEEAL 280


                  ....*..
gi 544583512  235 AALRRLR 241
Cdd:TIGR00898 281 KILQRIA 287
MFS_SV2 cd17363
Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic ...
 73-224 5.00e-08

Synaptic vesicle glycoprotein 2 of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. The SV2 family belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340921 [Multi-domain]  Cd Length: 474  Bit Score: 55.57  E-value: 5.00e-08
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLyplGGLFGALLAGPLAITLGRKKSLL----VNNIFvvsaAILFGFSRKAGSFemiMLGRLLVGVNAGVSMNI 148
Cdd:cd17363   38 MLGLIVYL---GMMVGAFVWGGLADKLGRKQCLLialsVNGVF----AFLSSFVQGYGFF---LFCRLLSGIGIGGSIPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 149 QPMYLGESAPKELRG----------------AVAMSSAIFTALG--IVMGQVVGLrellggpQAWPLLLASCLVPGALQL 210
Cdd:cd17363  108 VFSYFAEFLAREKRGehlswlcmfwmigglyASAMAWAIIPHYGwgFSMGTAYQF-------HSWRVFVIVCALPSVASV 180

                        170
                 ....*....|....
gi 544583512 211 ASLPLLPESPRYLL 224
Cdd:cd17363  181 VALTFMPESPRFLL 194
MFS_SV2A cd17439
Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; ...
 73-232 1.08e-07

Synaptic vesicle glycoprotein 2A of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. It is unclear how SV2A is involved in correct SV function, but it has been suggested to either act as a transporter or a regulator of exocytosis by mediating Ca2+ dynamics. SV2A has been identified as the molecular target of the antiepileptic drug levetiracetam (LEV). Its expression is decreased in patients with epilepsy and in epileptic animal models. SV2A belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340997 [Multi-domain]  Cd Length: 478  Bit Score: 54.27  E-value: 1.08e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLyplGGLFGALLAGPLAITLGRKKSLL----VNNIFVVSAAILFGFsrkaGSFemiMLGRLLVGVNAGVSMNI 148
Cdd:cd17439   38 MLGLIVYL---GMMVGAFLWGGLADRIGRRQCLLislsVNSVFAFFSSFVQGY----GTF---LFCRLLSGVGIGGSIPI 107

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 149 QPMYLGESAPKELRG----------------AVAMSSAIFTALG--IVMGQVVGLrellggpQAWPLLLASCLVPGALQL 210
Cdd:cd17439  108 VFSYFSEFLAQEKRGehlswlcmfwmiggiyASAMAWAIIPHYGwsFQMGSAYQF-------HSWRVFVLVCAFPSVFAI 180

                        170       180
                 ....*....|....*....|..
gi 544583512 211 ASLPLLPESPRYLLIDCGDTEA 232
Cdd:cd17439  181 GALTTMPESPRFFLENGKHDEA 202
MFS_GLUT10_Class3 cd17436
Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of ...
 22-225 1.12e-07

Glucose transporter type 10 (GLUT10), a Class 3 GLUT, of the Major Facilitator Superfamily of transporters; Glucose transporter type 10 (GLUT10) is also called Solute carrier family 2, facilitated glucose transporter member 10 (SLC2A10). It is classified as a Class 3 GLUT and is a facilitative glucose transporter that exhibits a wide tissue distribution. It is expressed in pancreas, placenta, heart, lung, liver, brain, fat, muscle, and kidney. GLUT10 facilitates the transport of dehydroascorbic acid (DHA), the oxidized form of vitamin C, into mitochondria, and also increases cellular uptake of DHA, which in turn protects cells against oxidative stress. Loss-of-function mutations in SLC2A10 cause arterial tortuosity syndrome (ATS), an autosomal recessive connective tissue disorder characterized by twisting and lengthening of the major arteries, hypermobility of the joints, and laxity of skin. The GLUT10 subfamily belongs to the Glucose transporter -like (GLUT-like) family of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340994 [Multi-domain]  Cd Length: 376  Bit Score: 54.04  E-value: 1.12e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  22 LTICAAGIGGtFQFGYNLSIINAPTLHIQeftnetwqartgepLPDHLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGR 101
Cdd:cd17436    1 LTATVSLLGG-LTFGYELGIISGALLQLQ--------------TDFSLSCFEQEALVSALLIGALLASLIGGFLIDRHGR 65

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 102 KKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMGQ 181
Cdd:cd17436   66 RTSILGSNLVLLAGSLILTL---AGSFFWLVIGRAVVGFAISVSSMACCIYVSEMVTPHQRGLLVSLYEAGITVGILISY 142

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|....
gi 544583512 182 VVGLrELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYLLI 225
Cdd:cd17436  143 ALNY-FFSNVLTGWRYMFGLAIIPAAIQFASILLLPKKPEVLNI 185
MFS_MdtG_SLC18_like cd17325
bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator ...
 72-184 2.38e-07

bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily of transporters; This family is composed of eukaryotic solute carrier 18 (SLC18) family transporters and related bacterial multidrug resistance (MDR) transporters including several proteins from Escherichia coli such as multidrug resistance protein MdtG, from Bacillus subtilis such as multidrug resistance proteins 1 (Bmr1) and 2 (Bmr2), and from Staphylococcus aureus such as quinolone resistance protein NorA. The family also includes Escherichia coli arabinose efflux transporters YfcJ and YhhS. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The SLC18 transporter family includes vesicular monoamine transporters (VAT1 and VAT2), vesicular acetylcholine transporter (VAChT), and SLC18B1, which is proposed to be a vesicular polyamine transporter (VPAT). The MdtG/SLC18 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340883 [Multi-domain]  Cd Length: 375  Bit Score: 52.96  E-value: 2.38e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  72 LMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPM 151
Cdd:cd17325   31 AQIGLIVAAYALAQLLFSPPAGRLSDRFGRKRLLLLGLLLLAVSTLLFAF---ATSYWQLLLARFLQGLASAAVWPAAMA 107

                         90       100       110
                 ....*....|....*....|....*....|....
gi 544583512 152 YLGESAPKELRGaVAMSSA-IFTALGIVMGQVVG 184
Cdd:cd17325  108 LIADIAPPEERG-RAMGIFsSAIGLGFLIGPLLG 140
MFS_SV2B cd17438
Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; ...
 73-224 4.81e-07

Synaptic vesicle glycoprotein 2B of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2B is a key modulator of amyloid toxicity at the synaptic site and also has an essential role in the formation and maintenance of the glomerular capillary wall. SV2B belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340996 [Multi-domain]  Cd Length: 477  Bit Score: 52.23  E-value: 4.81e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLyplGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFemiMLGRLLVGVNAGVSMNIQPMY 152
Cdd:cd17438   38 MLGLIVYL---GMMAGAFIWGGLADKLGRKRCLIISLAINASFAFLSSFVQGYGAF---LFCRLISGFGIGGSLPIVFAY 111

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 153 LGESAPKELRGAVAMSSAIFTALGIVMGQVV--------GLRELLGGP---QAWPLLLASCLVPGALQLASLPLLPESPR 221
Cdd:cd17438  112 FSEFLAREKRGEHLSWLCMFWMIGGLYASAMawsiiphyGWGFSMGTNyhfHSWRVFVIICALPCIASIIALKFMPESPR 191


                 ...
gi 544583512 222 YLL 224
Cdd:cd17438  192 FLL 194
MFS_SV2_like cd17316
Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the ...
 75-208 7.78e-07

Metazoan Synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters of the Major Facilitator Superfamily; This family is composed of metazoan synaptic vesicle glycoprotein 2 (SV2) and related small molecule transporters including those that transport inorganic phosphate (Pht), aromatic compounds (PcaK and related proteins), proline/betaine (ProP), alpha-ketoglutarate (KgtP), citrate (CitA), shikimate (ShiA), and cis,cis-muconate (MucK), among others. SV2 is a transporter-like protein that serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. Also included in this family is synaptic vesicle 2 (SV2)-related protein (SVOP) and similar proteins. SVOP is a transporter-like nucleotide binding protein that localizes to neurotransmitter-containing vesicles. The SV2-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340874 [Multi-domain]  Cd Length: 353  Bit Score: 51.06  E-value: 7.78e-07
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSmNIQPMYLG 154
Cdd:cd17316  216 SLYLLLISLGALVGALIAGLLSDRIGRKKTLVIGLILSGILALPLFYLLSGSPTLLLLLLFILSFFVGGVW-GALYAYLA 294

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 544583512 155 ESAPKELRG-AVAMSSAIFTALGIVMGQVVG-LRELLGGPQAWPLLLASCLVPGAL 208
Cdd:cd17316  295 ELFPTEVRAtGVGLSYNLGRLGGGGAPPLIAlLLASTGGTGVPALILALLAIVALI 350
MFS_NepI_like cd17324
Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator ...
 75-221 2.09e-06

Purine ribonucleoside efflux pump NepI and similar transporters of the Major Facilitator Superfamily; This family is composed of purine efflux pumps such as Escherichia coli NepI and Bacillus subtilis PbuE, sugar efflux transporters such as Corynebacterium glutamicum arabinose efflux permease, multidrug resistance (MDR) transporters such as Streptomyces lividans chloramphenicol resistance protein (CmlR), and similar proteins. NepI and PbuE are involved in the efflux of purine ribonucleosides such as guanosine, adenosine and inosine, as well as purine bases like guanine, adenine, and hypoxanthine, and purine base analogs. They play a role in the maintenance of cellular purine base pools, as well as in protecting the cells and conferring resistance against toxic purine base analogs such as 6-mercaptopurine. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. The NepI-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340882 [Multi-domain]  Cd Length: 370  Bit Score: 49.86  E-value: 2.09e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17324   37 GLLVSAYALGYALGALLLGPLSDRIERRRLLLVLLLLFILGNLLAAL---APSFALLLLARALAGLAHGGFWAIAAAYAA 113

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544583512 155 ESAPKELRGAV------AMSSAIFTA--LGIVMGQVVGLRELLGGPQAWPLLLAsclvpgALQLASLPLLPESPR 221
Cdd:cd17324  114 DLVPPEKRGRAiglvfsGLTLGLVLGrpLGGLLGQLLGWRAAFLAIAVLALLAA------LLLWRLLPSLPPKKP 182
MFS_SV2C cd17440
Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; ...
 79-224 7.74e-06

Synaptic vesicle glycoprotein 2C of the Major Facilitator Superfamily of transporters; Synaptic vesicle glycoprotein 2 (SV2) is a transporter-like integral membrane glycoprotein, with 12 transmembrane regions, expressed in vertebrates and is localized to synaptic and endocrine secretory vesicles. Three isoforms have been identified, SV2A, SV2B, and SV2C. SV2A and SV2B are widely expressed in the brain, while SV2C is more restricted to evolutionarily older brain. SV2 isoforms have been shown to be critical for the proper function of the central nervous system. SV2 serves as the receptor for botulinum neurotoxin A (BoNT/A), one of seven neurotoxins produced by the bacterium Clostridium botulinum. BoNT/A blocks neurotransmitter release by cleaving synaptosome-associated protein of 25 kD (SNAP-25) within presynaptic nerve terminals. SV2C exhibits enriched expression in several basal ganglia nuclei, and has been found to be involved in normal operation of the basal ganglia network and could be also be involved in system adaptation in basal ganglia pathological conditions. SV2C belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340998 [Multi-domain]  Cd Length: 479  Bit Score: 48.37  E-value: 7.74e-06
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  79 SLYPLGGLFGALLAGPLAITLGRKKSLL----VNNIFvvsaAILFGFSRKAGSFemiMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17440   41 SIVYLGMMVGAFFWGGLADKVGRRQSLLicmsVNGFF----AFLSSFVQGYGLF---LFCRLLSGFGIGGAVPTVFSYFA 113

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 155 ESAPKELRG----------------AVAMSSAIFTALG--IVMGQVVGLrellggpQAWPLLLASCLVPGALQLASLPLL 216
Cdd:cd17440  114 EVLAREKRGehlswlcmfwmiggiyASAMAWAIIPHYGwsFSMGSAYQF-------HSWRVFVIVCALPCVSSVVALTFM 186


                 ....*...
gi 544583512 217 PESPRYLL 224
Cdd:cd17440  187 PESPRFLL 194
MFS_1 pfam07690
Major Facilitator Superfamily;
75-184 9.17e-06

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 47.80  E-value: 9.17e-06
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:pfam07690  35 GLLLTLFSLGYALAQPLAGRLSDRFGRRRVLLIGLLLFALGLLLLLF---ASSLWLLLVLRVLQGLGAGALFPAALALIA 111

                          90       100       110
                  ....*....|....*....|....*....|
gi 544583512  155 ESAPKELRGAVAMSSAIFTALGIVMGQVVG 184
Cdd:pfam07690 112 DWFPPEERGRALGLVSAGFGLGAALGPLLG 141
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
73-184 1.00e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.94  E-value: 1.00e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMY 152
Cdd:COG2271   46 QLGLLASAFFLGYALGQIPAGLLADRFGRRRVLAIGLLLWGLATLLFGF---ATSFWQLLLLRFLLGLGEAGFFPAALKL 122

                         90       100       110
                 ....*....|....*....|....*....|..
gi 544583512 153 LGESAPKELRGAVAMSSAIFTALGIVMGQVVG 184
Cdd:COG2271  123 IAEWFPPKERGRALGIFNAGGPLGGALAPPLL 154
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
68-208 1.34e-05

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 47.57  E-value: 1.34e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  68 HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVnnIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMN 147
Cdd:COG2223  237 GLSAATAGLLAALFALLGALGRPLGGWLSDRIGGRRVLLI--VFALMALGLLLLALALGSLWLFLVLFLLLGLALGGGNG 314

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544583512 148 IQPMYLGESAPKELRGAV-AMSSAIFTALGIVMGQVVG-LRELLGGPQAWPLLLASCLVPGAL 208
Cdd:COG2223  315 AVFALVPDIFPTKNAGAVyGLVGAAGGLGGFLGPLLFGaLLDATGSYTAAFLVFAVLALVALV 377
UhpC COG2271
Sugar phosphate permease [Carbohydrate transport and metabolism];
75-221 1.64e-05

Sugar phosphate permease [Carbohydrate transport and metabolism];


Pssm-ID: 441872 [Multi-domain]  Cd Length: 363  Bit Score: 47.17  E-value: 1.64e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVnNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG2271  219 GLLLSLPFLAGIVGSLLGGWLSDRLGRRRKLVL-AIGLLLAALALLLLALLPSPALAIALLFLAGFGLGGAFGLLWALAA 297

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 155 ESAPKELRG-AVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGAlqLASLPLLPESPR 221
Cdd:COG2271  298 ELFPKKARGtASGLVNTFGFLGGALGPLLVGYLLDATGYQAAFLLLAALALLAA--LLALLLLRETRK 363
MFS_PcaK_like cd17365
4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator ...
 75-216 2.13e-05

4-hydroxybenzoate transporter PcaK and similar transporters of the Major Facilitator Superfamily; This aromatic acid:H(+) symporter subfamily includes Acinetobacter sp. 4-hydroxybenzoate transporter PcaK, Pseudomonas putida gallate transporter (GalT), Corynebacterium glutamicum gentisate transporter (GenK), Nocardioides sp. 1-hydroxy-2-naphthoate transporter (PhdT), Escherichia coli 3-(3-hydroxy-phenyl)propionate (3HPP) transporter (MhpT), and similar proteins. These transporters are involved in the uptake across the cytoplasmic membrane of specific aromatic compounds such as 4-hydroxybenzoate, gallate, gentisate (2,5-dihydroxybenzoate), 1-hydroxy-2-naphthoate, and 3HPP, respectively. The PcaK-like aromatic acid:H(+) symporter subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340923 [Multi-domain]  Cd Length: 351  Bit Score: 46.81  E-value: 2.13e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17365   37 GPVGSAALFGMAIGALLAGPLADRFGRKRVLLVSVALFGLFTLLTAF---AQSVLQLALLRFLTGLGLGAAMPNAITLVS 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544583512 155 ESAPKELRGavAMSSAIFT--ALGIVMGQVVGLreLLGGPQAWPLLLASCLVPGalqLASLPLL 216
Cdd:cd17365  114 EYAPARRRS--LAVTLMFCgyPLGAALGGFLAA--ALIPAFGWRSVFLLGGVPP---LILLPLL 170
MFS_PhT cd17364
Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This ...
 24-208 2.27e-05

Inorganic Phosphate Transporter of the Major Facilitator Superfamily of transporters; This subfamily is composed of predominantly fungal and plant high-affinity inorganic phosphate transporters (PhT or PiPT), which are involved in the uptake, translocation, and internal transport of inorganic phosphate. They also function in sensing external phosphate levels as transceptors. Phosphate is crucial for structural and metabolic needs, including nucleotide and lipid synthesis, signalling and chemical energy storage. The Pht subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340922 [Multi-domain]  Cd Length: 389  Bit Score: 46.89  E-value: 2.27e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  24 ICAAGIGgTFQFGYNLSIINaptLHIQEFTNETWQARTGEPLPDHlvllmwSLIVSLYPLGGLFGALLAGPLAITLGRKK 103
Cdd:cd17364    1 IIIAGMG-FFTDAYDLFSIS---LVTKILGRLYYGGKGSLPSGVS------GLVNAAALVGTIIGQLFFGFLGDRFGRKR 70

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 104 SLLVNNIFVVSAAILFGFSRKA---GSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAPKELRGAVAMSSAIFTALGIVMG 180
Cdd:cd17364   71 VYGVELIIMIIGTILSALSPGStplGVMGWLIFFRFLLGIGIGGDYPLSATIMSEYANKKRRGALIAAVFAMQGFGILAG 150

                        170       180       190       200
                 ....*....|....*....|....*....|....*....|
gi 544583512 181 QVVGLRELLGGP------------QAWPLLLASCLVPGAL 208
Cdd:cd17364  151 AIVTLILSAIFEhplpagtyhhadLVWRIVLGLGAIPALS 190
MFS_SLC22 cd17317
Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major ...
 75-217 2.36e-05

Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters of the Major Facilitator Superfamily; The Solute carrier 22 (SLC22) family of organic cation/anion/zwitterion transporters includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. The SLC22 family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340875 [Multi-domain]  Cd Length: 331  Bit Score: 46.42  E-value: 2.36e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGV-NAGVSMNIQpMYL 153
Cdd:cd17317   28 ALVQTIFFLGVLIGSLLFGYLADRFGRRPVLLLGLVLQIVCGVLSAFSP---SYELFLVLRFLVGVtSAGIFTVGF-VLG 103

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 154 GESAPKELRGAVAMSSAIFTALGIVmgqvvglreLLGG----PQAWPLLLASCLVPGALQLASLPLLP 217
Cdd:cd17317  104 MEIVGPKYRSFVGILFGLFWALGYM---------LLALlaylIRDWRWLQLAISLPGLLFLLLLWWLP 162
MFS_YfmO_like cd17474
Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major ...
 75-221 5.94e-05

Bacillus subtilis multidrug efflux protein YfmO and similar transporters of the Major Facilitator Superfamily; This family is composed of Bacillus subtilis multidrug efflux protein YfmO, bacillibactin exporter YmfD/YmfE, uncharacterized MFS-type transporter YvmA, and similar proteins. YfmO acts to efflux copper or a copper complex, and could contribute to copper resistance. YmfD/YmfE is involved in secretion of bacillibactin. The YfmO-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341027 [Multi-domain]  Cd Length: 374  Bit Score: 45.25  E-value: 5.94e-05
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSrkaGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17474   37 GLLITAFTLPAAVLMPVAGVLADRFGRKKVLLPGLLLFGIGGLLCGLS---DSFALLLAGRALQGIGAAGLGPLALTLIG 113

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVVGlrELLGG-PQAWPLLLASCLVPGALqLASLPLLPESPR 221
Cdd:cd17474  114 DLFEGGERAKAMGLYEAALGLGIAVGPLLG--GLLAAiSWRYPFFLLAALIPVAF-LAILFLLPEPKE 178
PRK11551 PRK11551
putative 3-hydroxyphenylpropionic transporter MhpT; Provisional
 83-223 1.04e-04

putative 3-hydroxyphenylpropionic transporter MhpT; Provisional


Pssm-ID: 236927 [Multi-domain]  Cd Length: 406  Bit Score: 44.57  E-value: 1.04e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  83 LGGLFGALLAGPLAITLGRKKSLLVnnifvvsAAILFG-FS---RKAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGESAP 158
Cdd:PRK11551  61 LGLLPGALLGGRLADRIGRKRILIV-------SVALFGlFSlatAQAWDFPSLLVARLLTGVGLGGALPNLIALTSEAVG 133

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*..
gi 544583512 159 KELRG-AV-AMSSAIftALGIVMGQVVGLreLLGGPQAW----------PLLLASCLvpgalqlasLPLLPESPRYL 223
Cdd:PRK11551 134 PRLRGtAVsLMYCGV--PFGGALASVIGV--LAAGDAAWrhifyvggvgPLLLVPLL---------MRWLPESRAFA 197
MFS_MucK cd17371
Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; ...
 76-223 1.23e-04

Cis,cis-muconate transport protein and similar proteins of the Major Facilitator Superfamily; This subfamily is composed of Acinetobacter sp. Cis,cis-muconate transport protein (MucK), Escherichia coli putative sialic acid transporter 1, and similar proteins. MucK functions in the uptake of muconate and allows Acinetobacter calcoaceticus ADP1 (BD413) to grow on exogenous cis,cis-muconate as the sole carbon source. The MucK subfamily belongs to the Metazoan Synaptic Vesicle Glycoprotein 2 (SV2) and related small molecule transporter family (SV2-like) of the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340929 [Multi-domain]  Cd Length: 389  Bit Score: 44.60  E-value: 1.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  76 LIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGE 155
Cdd:cd17371   38 LLGTVTLAGGAIGGILGGILADRFGRVRVLVITILLFAVFTLLCGF---AQNYWQLLILRALAGLGFGGEWAAGAALMAE 114

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512 156 SAPKELRGAVAMSSAIFTALGIVMGQVVG--LRELLGGPQAWPLLLASCLVPGALQLASLPLLPESPRYL 223
Cdd:cd17371  115 YVPARHRGKALGYVQSGWAVGWLLATLLAalLFPLLPPEIAWRVLFLLGALPALLVLFIRRFVKEPPQWQ 184
MFS_1 pfam07690
Major Facilitator Superfamily;
68-180 1.77e-04

Major Facilitator Superfamily;


Pssm-ID: 429598 [Multi-domain]  Cd Length: 344  Bit Score: 43.95  E-value: 1.77e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   68 HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRKAGSFEMIMLGRLLVGVNAGVSMN 147
Cdd:pfam07690 231 GLSALLAGLLLGLGGLLGAIGRLLLGRLSDRLGRRRRLLLALLLLILAALGLLLLSLTLSSLWLLLALLLLGFGFGLVFP 310

                          90       100       110
                  ....*....|....*....|....*....|...
gi 544583512  148 IQPMYLGESAPKELRGAVAMSSAIFTALGIVMG 180
Cdd:pfam07690 311 ALNALVSDLAPKEERGTASGLYNTAGSLGGALG 343
2A0109 TIGR00887
phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the ...
 84-222 2.02e-04

phosphate:H+ symporter; This model represents the phosphate uptake symporter subfamily of the major facilitator superfamily (pfam00083). [Transport and binding proteins, Anions]


Pssm-ID: 129965 [Multi-domain]  Cd Length: 502  Bit Score: 43.95  E-value: 2.02e-04
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   84 GGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFG--FSRKAGSFEM-IMLGRLLVGVNAGVSMNIQPMYLGESAPKE 160
Cdd:TIGR00887  68 GTLAGQLFFGWLADKLGRKRVYGMELIIMIIATVASGlsPGSSPKSVMAtLCFWRFWLGVGIGGDYPLSAIITSEFATKK 147

                          90       100       110       120       130       140       150       160
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  161 LRGavAMSSAIFT--ALGIVMGQVVGLRELLG------------------GPQA---WPLLLASCLVPGALQLASLPLLP 217
Cdd:TIGR00887 148 WRG--AMMAAVFAmqGFGILAGAIVALIVLAGfkhsleaaadeasctgscVPAVdymWRILIGFGAVPALLALYFRLTIP 225


                  ....*
gi 544583512  218 ESPRY 222
Cdd:TIGR00887 226 ETPRY 230
NarK COG2223
Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];
75-180 2.67e-04

Nitrate/nitrite transporter NarK [Inorganic ion transport and metabolism];


Pssm-ID: 441825 [Multi-domain]  Cd Length: 392  Bit Score: 43.33  E-value: 2.67e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG2223   43 GLLFAIPVLVGALLRIPLGFLVDRFGPRRVLLIGLLLLGIGLLLLAL---AVSYWLLLLLGLLLGIGGGGSFAVGIALVS 119

                         90       100
                 ....*....|....*....|....*.
gi 544583512 155 ESAPKELRGavamssaifTALGIVMG 180
Cdd:COG2223  120 KWFPPDRRG---------LALGLAAG 136
MFS_MefA_like cd06173
Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of ...
 73-213 2.94e-04

Macrolide efflux protein A and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of Streptococcus pyogenes macrolide efflux protein A (MefA) and similar transporters, many of which remain uncharacterized. Some members may be multidrug resistance (MDR) transporters, which are drug/H+ antiporters (DHAs) that mediate the efflux of a variety of drugs and toxic compounds, conferring resistance to these compounds. MefA confers resistance to 14-membered macrolides including erythromycin and to 15-membered macrolides. It functions as an efflux pump to regulate intracellular macrolide levels. The MefA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340863 [Multi-domain]  Cd Length: 383  Bit Score: 43.37  E-value: 2.94e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMY 152
Cdd:cd06173  245 GYGLLLAAFGVGALLGALLLGRLSKRRRRGRLLLIGALLLGLALLVLGLSP---SLWLLLAALFLLGLAGGLFNVPLNTL 321

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544583512 153 LGESAPKELRGAV----AMSSAIFTALGIVMGQVVGLRellGGPQAWPLLLASCLVPGALQLASL 213
Cdd:cd06173  322 LQLRVPDELRGRVfsvyNALNSGAMPLGALLAGLLADA---LGLSAVFLLAGALLLLAALLLLLL 383
MFS_MFSD9 cd17390
Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily ...
 76-203 4.23e-04

Major facilitator superfamily domain-containing protein 9; Major facilitator superfamily domain-containing protein 9 (MFSD9) is expressed in the central nervous system (CNS) and in most peripheral tissues but at very low expression levels. The function of MFSD9 is unknown. MFSD9 belongs to the Eukaryotic Solute carrier 46 (SLC46)/Bacterial Tetracycline resistance (TetA) -like (SLC46/TetA-like) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340948 [Multi-domain]  Cd Length: 350  Bit Score: 42.60  E-value: 4.23e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  76 LIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGvSMNIQPMYLGE 155
Cdd:cd17390   35 LIGSVYGALQLFSSPLVGSWSDVVGRRPVLLICLLLTALGYVLLGFST---SLALLFLSRIPLGIFKH-TQSLCKAYLSD 110

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 544583512 156 SAPKELRGAVAMSSAIFTALGIVMGQVVG--LRELLGGPQaWPLLLASCL 203
Cdd:cd17390  111 LVSEQERSRVLGRFNAASSLGFILGPVVGghLAETDGGFY-YVALLCSAI 159
AraJ COG2814
Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];
75-182 6.63e-04

Predicted arabinose efflux permease AraJ, MFS family [Carbohydrate transport and metabolism];


Pssm-ID: 442063 [Multi-domain]  Cd Length: 348  Bit Score: 41.88  E-value: 6.63e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:COG2814  246 GLLLALFGLGGVLGALLAGRLADRFGRRRLLLIGLLLLALGLLLLAL---AGSLWLLLLALFLLGFGFGLLFPLLQALVA 322

                         90       100
                 ....*....|....*....|....*...
gi 544583512 155 ESAPKELRGAVamsSAIFTALGIVMGQV 182
Cdd:COG2814  323 ELAPPEARGRA---SGLYNSAFFLGGPL 347
MFS_YfcJ_like cd17489
Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; ...
 76-186 7.64e-04

Escherichia coli YfcJ, YhhS, and similar transporters of the Major Facilitator Superfamily; This subfamily is composed of Escherichia coli membrane proteins, YfcJ and YhhS, Bacillus subtilis uncharacterized MFS-type transporter YwoG, and similar proteins. YfcJ and YhhS are putative arabinose efflux transporters. YhhS has been implicated glyphosate resistance. YfcJ-like arabinose efflux transporters belong to the bacterial MdtG-like and eukaryotic solute carrier 18 (SLC18) family of the Major Facilitator Superfamily (MFS) of transporters. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341042 [Multi-domain]  Cd Length: 367  Bit Score: 41.81  E-value: 7.64e-04
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  76 LIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLGE 155
Cdd:cd17489   35 LVVGLFTLAALLARPFAGRLLDRFGRKRLLLIGLLIFALATLLYLL---ATSVALLLVLRLIHGIGWGAFTTAAATLVAD 111

                         90       100       110
                 ....*....|....*....|....*....|....*....
gi 544583512 156 SAPKELRG--------AVAMSSAIFTALGIVMGQVVGLR 186
Cdd:cd17489  112 IIPPSRRGegigyyglATTLAMALGPALGLFLYQHLGFA 150
MFS_SLC46_TetA_like cd17330
Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and ...
 68-225 1.05e-03

Eukaryotic Solute carrier 46 (SLC46) family, Bacterial Tetracycline resistance proteins, and similar proteins of the Major Facilitator Superfamily of transporters; This family is composed of the eukaryotic proteins MFSD9, MFSD10, MFSD14, and SLC46 family proteins, as well as bacterial multidrug resistance (MDR) transporters such as tetracycline resistance protein TetA and multidrug resistance protein MdtG. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. TetA proteins confer resistance to tetracycline while MdtG confers resistance to fosfomycin and deoxycholate. The Solute carrier 46 (SLC46) family is composed of three vertebrate members (SLC46A1, SLC46A2, and SLC46A3), the best-studied of which is SLC46A1, which functions both as an intestinal proton-coupled high-affinity folate transporter involved in the absorption of folates and as an intestinal heme transporter which mediates heme uptake. MFSD10 facilitates the uptake of organic anions such as some non-steroidal anti-inflammatory drugs (NSAIDs) and confers resistance to such NSAIDs. The SLC46/TetA-like family belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340888 [Multi-domain]  Cd Length: 349  Bit Score: 41.41  E-value: 1.05e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  68 HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMN 147
Cdd:cd17330   30 GASGYYVGLLQSSYSLGQFLASPLWGRLSDRYGRKPVLLLSLAGSAVSYVLLGLSR---NLWLLFLARFLDGLTGGNVSV 106

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*...
gi 544583512 148 IQPMYLGESAPKELRGAVAMSSAIFtALGIVMGQVVGLRELLGGPQAWPLLLASCLVPGALqLASLPLLPESPRYLLI 225
Cdd:cd17330  107 AQAYIADITDEEERAKAFGIISAAF-GLGFILGPALGGFLSTPYGYALPFLVAAALALLNL-VLVLFFLPPLRRLLLV 182
MFS_YcaD_like cd17477
YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of ...
 76-216 1.45e-03

YcaD and similar transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MFS-type transporter YcaD, Bacillus subtilis MFS-type transporter YfkF, and similar proteins. They are uncharacterized transporters belonging to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 341030 [Multi-domain]  Cd Length: 360  Bit Score: 41.00  E-value: 1.45e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  76 LIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMYLGE 155
Cdd:cd17477   35 LVASAYYLGILLGSPLVPRLIRRVGHIRAFAAGAAITAVSVLLLALTD---SPWVWFLLRFVMGIGLAGLFVVSESWLNA 111

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544583512 156 SAPKELRGAVAMSSAIFTALGIVMGQVVGlreLLGGPQAW-PLLLASCLvpgaLQLASLPLL 216
Cdd:cd17477  112 LATNENRGRVLGLYSTVLGLGFALGPLLL---ALVGTAGAlPFLIAAVL----LLLALVPLL 166
MelB COG2211
Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];
68-209 2.28e-03

Na+/melibiose symporter or related transporter [Carbohydrate transport and metabolism];


Pssm-ID: 441813 [Multi-domain]  Cd Length: 447  Bit Score: 40.66  E-value: 2.28e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  68 HLVLLMWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkAGSFEMIMLGRLLVGVNAGVSMN 147
Cdd:COG2211  260 GLSAALVGLLLALYFLAALLGAPLWPRLAKRFGKKKAFIIGLLLAALGLLLLFFLG-PGNLWLLLVLAALAGIGLGAILV 338

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|..
gi 544583512 148 IQPMYLGESAPKELRGAVAMSSAIFTALgIVMGQVVGLreLLGGPQAWPLLLASCLVPGALQ 209
Cdd:COG2211  339 LPWAMLADVVDYDEWKTGRRREGLYFGI-FTFAIKLGQ--ALAGALAGLLLALFGYVAGAAQ 397
MFS_Tpo1_MDR_like cd17323
Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of ...
 73-184 2.39e-03

Yeast Polyamine transporter 1 (Tpo1) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of fungal multidrug resistance (MDR) transporters including several proteins from Saccharomyces cerevisiae such as polyamine transporters 1-4 (Tpo1-4), quinidine resistance proteins 1-3 (Qdr1-3), dityrosine transporter 1 (Dtr1), fluconazole resistance protein 1 (Flr1), and protein HOL1. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, Flr1 confers resistance to the azole derivative fluconazole while Tpo1 confers resistance and adaptation to quinidine and ketoconazole. The polyamine transporters are involved in the detoxification of excess polyamines in the cytoplasm. Tpo1-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340881 [Multi-domain]  Cd Length: 376  Bit Score: 40.25  E-value: 2.39e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  73 MWSLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFSRkagSFEMIMLGRLLVGVNAGVSMNIQPMY 152
Cdd:cd17323   35 VANLGVSLFVLGFGLGPLIWAPLSELYGRRPVYLVSLFIFVIFQIGCALAP---NIAMLIILRFLQGFFGSSPLAIGAGT 111

                         90       100       110
                 ....*....|....*....|....*....|..
gi 544583512 153 LGESAPKELRGAVAMSSAIFTALGIVMGQVVG 184
Cdd:cd17323  112 IADLFTPEERGKAMGVYSLGPLLGPALGPIIG 143
MFS_MMR_MDR_like cd17321
Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance ...
 75-184 3.42e-03

Methylenomycin A resistance protein (also called MMR peptide) and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of bacterial, fungal, and archaeal multidrug resistance (MDR) transporters including several proteins from Bacilli such as methylenomycin A resistance protein (also called MMR peptide), tetracycline resistance protein (TetB), and lincomycin resistance protein LmrB, as well as fungal proteins such as vacuolar basic amino acid transporters, which are involved in the transport into vacuoles of the basic amino acids histidine, lysine, and arginine in Saccharomyces cerevisiae, and aminotriazole/azole resistance proteins. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. For example, MMR confers resistance to the epoxide antibiotic methylenomycin while TetB resistance to tetracycline by an active tetracycline efflux. MMR-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340879 [Multi-domain]  Cd Length: 370  Bit Score: 39.85  E-value: 3.42e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGglFGALL--AGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMY 152
Cdd:cd17321   34 QWVVNAYLLA--FAALLllAGRLGDRFGRKRVFLIGLALFGLASLLCAL---APSLAFLIAARALQGIGAAAIMPASLAL 108

                         90       100       110
                 ....*....|....*....|....*....|...
gi 544583512 153 LGESAPKELRG-AVAMSSAIFtALGIVMGQVVG 184
Cdd:cd17321  109 IAATFPGERRGrALGLWGAVV-GIGAALGPLLG 140
FucP COG0738
Fucose permease [Carbohydrate transport and metabolism];
75-184 3.63e-03

Fucose permease [Carbohydrate transport and metabolism];


Pssm-ID: 440501 [Multi-domain]  Cd Length: 391  Bit Score: 39.84  E-value: 3.63e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAG---VSMNIqpm 151
Cdd:COG0738   46 GLLLFAFFLGYLLASLPAGRLIDRFGYKRGLLLGLLLMALGLLLFAL---APSYPLLLLALFLLGLGLGlldVAANP--- 119

                         90       100       110
                 ....*....|....*....|....*....|....
gi 544583512 152 YLGESAPKelRGAVAMSSA-IFTALGIVMGQVVG 184
Cdd:COG0738  120 YVAALGPE--TAASRLNLLhAFFSLGALLGPLLG 151
2A0115 TIGR00895
benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and ...
 77-223 5.65e-03

benzoate transport; [Transport and binding proteins, Carbohydrates, organic alcohols, and acids]


Pssm-ID: 273327 [Multi-domain]  Cd Length: 398  Bit Score: 39.26  E-value: 5.65e-03
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512   77 IVSLYPLGGLFGALLAGPLAITLGRKK----SLLVNNIFVVSAAIlfgfsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMY 152
Cdd:TIGR00895  57 LFSAGLIGMAFGALFFGPLADRIGRRRvllwSILLFSVFTLLCAL-------ATNVTQLLILRFLAGLGLGGLMPNLNAL 129

                          90       100       110       120       130       140       150
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544583512  153 LGESAPKELRGAVAMSSAIFTALGIVMGQVVGlrELLGGPQAWPLLLascLVPGALQLASLPL----LPESPRYL 223
Cdd:TIGR00895 130 VSEYAPKRFRGTAVGLMFCGYPIGAAVGGFLA--GWLIPVFGWRSLF---YVGGIAPLLLLLLlmrfLPESIDFL 199
MFS_MdtH_MDR_like cd17329
Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the ...
 75-204 6.94e-03

Multidrug resistance protein MdtH and similar multidrug resistance (MDR) transporters of the Major Facilitator Superfamily; This family is composed of Escherichia coli MdtH and similar multidrug resistance (MDR) transporters from bacteria and archaea, many of which remain uncharacterized. MDR transporters are drug/H+ antiporters (DHA) that mediate the efflux of a variety of drugs and toxic compounds, and confer resistance to these compounds. MdtH confers resistance to norfloxacin and enoxacin. MdtH-like MDR transporters belong to the Major Facilitator Superfamily (MFS) of membrane transport proteins, which are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340887 [Multi-domain]  Cd Length: 376  Bit Score: 38.75  E-value: 6.94e-03
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGVNAGVSMNIQPMYLG 154
Cdd:cd17329   38 GLVLALSAVAGIVASLIGGRLADRFGRKPVMLAGLLLRALGFALLGF---AHSPWLFAIALVLTGFGGGLFEPASEAMIA 114

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 544583512 155 ESAPKELRGAVAMSSAIFTALGIVMGQVVGLRELLGGPQAWPLLLASCLV 204
Cdd:cd17329  115 DVTTPENRTRAFSLLYWAINLGVAIGPLLGGLLLLYSFRLLFLAAAVLFL 164
MFS_SLC22A15 cd17377
Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; ...
 75-146 7.45e-03

Solute carrier family 22 member 15 of the Major Facilitator Superfamily of transporters; Solute carrier family 22 member 15 (SLC22A15) is also called fly-like putative transporter 1 (FLIPT1). It is expressed at the highest levels in the kidney and brain. It is a member of the SLC22 family of transporters, which includes organic cation transporters (OCTs), organic zwitterion/cation transporters (OCTNs), and organic anion transporters (OATs). SLC22 transporters interact with a variety of compounds that include drugs of abuse, environmental toxins, opioid analgesics, antidepressant and anxiolytic agents, and neurotransmitters and their metabolites. SLC22A15 belongs to the Major Facilitator Superfamily (MFS) of membrane transport proteins. MFS proteins are thought to function through a single substrate binding site, alternating-access mechanism involving a rocker-switch type of movement.


Pssm-ID: 340935 [Multi-domain]  Cd Length: 353  Bit Score: 38.61  E-value: 7.45e-03
                         10        20        30        40        50        60        70
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|...
gi 544583512  75 SLIVSLYPLGGLFGALLAGPLAITLGRKKSLLVNNIFVVSAAILFGFsrkAGSFEMIMLGRLLVGV-NAGVSM 146
Cdd:cd17377   42 SLASSFFFAGVLIGVVSFGQLSDRFGRKPVYLTGLALDILFAYFNAL---APSYEFFAVSRFLVGVmNGGMSL 111
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
Help | Disclaimer | Write to the Help Desk
NCBI | NLM | NIH