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Conserved domains on  [gi|544346261|ref|NP_001269715|]
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phosphoribosyltransferase domain-containing protein 1 isoform 2 [Homo sapiens]

Protein Classification

type I phosphoribosyltransferase( domain architecture ID 27)

type I phosphoribosyltransferase similar to phosphoribosyltransferases with specificities for hypoxanthine, guanine, and/or xanthine

Graphical summary

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List of domain hits

 Name Accession Description Interval E-value
PRTases_typeI super family cl00309
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 7-184 1.53e-56

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


The actual alignment was detected with superfamily member PTZ00149:

Pssm-ID: 444823  Cd Length: 241  Bit Score: 178.42  E-value: 1.53e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIgGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIV-SDDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180
                 ....*....|....*....|....*..
gi 544346261 158 EKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGD 200
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 7-184 1.53e-56

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 178.42  E-value: 1.53e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIgGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIV-SDDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180
                 ....*....|....*....|....*..
gi 544346261 158 EKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGD 200
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-184 1.67e-39

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 132.37  E-value: 1.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRND-QSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544346261  121 MQIIGGDDLSTLaGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVD 134
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-184 8.65e-34

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 117.82  E-value: 8.65e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRN-DQSMGE 120
Cdd:COG0634    8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544346261 121 MQIIGGDDLStLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:COG0634   79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPAD 141
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-182 6.51e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.90  E-value: 6.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  53 IERLAKDIMKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTL 132
Cdd:cd06223    2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 544346261 133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFR 182
Cdd:cd06223   70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELA 119
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-177 8.90e-18

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 75.86  E-value: 8.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   46 HGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYRNDQSMGEMQIig 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSYNPDTSEVMKTS-- 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 544346261  126 gDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSR 177
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGT 125
 
Name Accession Description Interval E-value
PTZ00149 PTZ00149
hypoxanthine phosphoribosyltransferase; Provisional
 7-184 1.53e-56

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 240293  Cd Length: 241  Bit Score: 178.42  E-value: 1.53e-56
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   7 EAPDYGRG------VVIMDDwPGYDLNLFTYPQHYYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYK 80
Cdd:PTZ00149  16 SYDYVGAGedrkepIYIKDD-DFYDLDSFLIPPHYKNYLTKILLPNGLIKDRVEKLAYDIKQVYGNEELHILCILKGSRG 94

                         90       100       110       120       130       140       150       160
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  81 FCADLVEHLKNISRNSDRFVSMKV---DFIRLKSYRNDQSMGEMQIIgGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNI 157
Cdd:PTZ00149  95 FFSALVDYLNRIHNYSSTESPKPPyqeHYVRVKSYCNDESTGKLEIV-SDDLSCLKDKHVLIVEDIIDTGNTLVKFCEYL 173

                        170       180
                 ....*....|....*....|....*..
gi 544346261 158 EKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:PTZ00149 174 KKFEPKTIRIATLFEKRTPLSNGFKGD 200
HGPRTase TIGR01203
hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine ...
 42-184 1.67e-39

hypoxanthine phosphoribosyltransferase; Alternate name: hypoxanthine-guanine phosphoribosyltransferase. Sequence differences as small as a single residue can affect whether members of this family act on hypoxanthine and guanine or hypoxanthine only. The designation of this model as equivalog reflects hypoxanthine specificity and does not reflect whether or not guanine can replace hypoxanthine. [Purines, pyrimidines, nucleosides, and nucleotides, Salvage of nucleosides and nucleotides]


Pssm-ID: 273497  Cd Length: 166  Bit Score: 132.37  E-value: 1.67e-39
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRND-QSMGE 120
Cdd:TIGR01203   1 VLIPEEQIKARIAELAKQITEDYAGKPLVLLCVLKGSFPFFADLIRYIA---------VPVQVDFMAVSSYGNGmQSSGD 71

                          90       100       110       120       130       140
                  ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544346261  121 MQIIGGDDLSTLaGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:TIGR01203  72 VKILKDLDLDIK-GKDVLIVEDIVDTGLTLQYLLDLLKARKPKSLKIVTLLDKPSRRKVDVKVD 134
HptA COG0634
Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; ...
 42-184 8.65e-34

Hypoxanthine-guanine phosphoribosyltransferase [Nucleotide transport and metabolism]; Hypoxanthine-guanine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440399  Cd Length: 176  Bit Score: 117.82  E-value: 8.65e-34
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  42 VLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRN-DQSMGE 120
Cdd:COG0634    8 VLISEEEIQARVKELAAQITADYAGKEPLVVGVLKGAFVFMADLLRALD---------FPLEIDFMHVSSYGGgTESSGE 78

                         90       100       110       120       130       140
                 ....*....|....*....|....*....|....*....|....*....|....*....|....
gi 544346261 121 MQIIGGDDLStLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPD 184
Cdd:COG0634   79 VRILKDLDED-IEGRDVLIVEDIIDTGLTLSYLLELLKSRGPASVKIATLLDKPERRKVDVPAD 141
PLN02238 PLN02238
hypoxanthine phosphoribosyltransferase
 35-188 2.50e-23

hypoxanthine phosphoribosyltransferase


Pssm-ID: 215132  Cd Length: 189  Bit Score: 91.25  E-value: 2.50e-23
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  35 YYGDLEYVLIPHGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNISRnsdrfvSMKVDFIRLKSY-R 113
Cdd:PLN02238   3 YEVDIEKVLWTAEDISARVAELAAQIASDYAGKSPVVLGVATGAFMFLADLVRAIQPLPR------GLTVDFIRASSYgG 76

                         90       100       110       120       130       140       150
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*
gi 544346261 114 NDQSMGEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFRPDSHMR 188
Cdd:PLN02238  77 GTESSGVAKVSGADLKIDVKGKHVLLVEDIVDTGNTLSALVAHLEAKGAASVSVCALLDKRARRKVKYELVGDGK 151
Hpt1 COG2236
Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine ...
 49-184 1.55e-19

Hypoxanthine phosphoribosyltransferase [Coenzyme transport and metabolism]; Hypoxanthine phosphoribosyltransferase is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 441837 [Multi-domain]  Cd Length: 153  Bit Score: 80.66  E-value: 1.55e-19
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  49 IVDRIERLAKDIMKDiGYSDIMVLCVLKGGYkFCADLVEHLKNISRnsdrfvsmkVDFIRLKSYRNDQSMGEMQIIGGDD 128
Cdd:COG2236   14 IHELSRRLAEQILES-GFRPDVIVAIARGGL-VPARILADALGVPD---------LASIRVSSYTGTAKRLEEPVVKGPL 82

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 544346261 129 LSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRsdgFRPD 184
Cdd:COG2236   83 DEDLAGKRVLIVDDVADTGRTLEAVRDLLKEAGPAEVRTAVLYYKPSSK---FKPD 135
PRTases_typeI cd06223
Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The ...
 53-182 6.51e-18

Phosphoribosyl transferase (PRT)-type I domain; Phosphoribosyl transferase (PRT) domain. The type I PRTases are identified by a conserved PRPP binding motif which features two adjacent acidic residues surrounded by one or more hydrophobic residue. PRTases catalyze the displacement of the alpha-1'-pyrophosphate of 5-phosphoribosyl-alpha1-pyrophosphate (PRPP) by a nitrogen-containing nucleophile. The reaction products are an alpha-1 substituted ribose-5'-phosphate and a free pyrophosphate (PP). PRPP, an activated form of ribose-5-phosphate, is a key metabolite connecting nucleotide synthesis and salvage pathways. The type I PRTase family includes a range of diverse phosphoribosyl transferase enzymes and regulatory proteins of the nucleotide synthesis and salvage pathways, including adenine phosphoribosyltransferase EC:2.4.2.7., hypoxanthine-guanine-xanthine phosphoribosyltransferase, hypoxanthine phosphoribosyltransferase EC:2.4.2.8., ribose-phosphate pyrophosphokinase EC:2.7.6.1., amidophosphoribosyltransferase EC:2.4.2.14., orotate phosphoribosyltransferase EC:2.4.2.10., uracil phosphoribosyltransferase EC:2.4.2.9., and xanthine-guanine phosphoribosyltransferase EC:2.4.2.22.


Pssm-ID: 206754 [Multi-domain]  Cd Length: 130  Bit Score: 75.90  E-value: 6.51e-18
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  53 IERLAKDIMKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfvsMKVDFIRLKSYRNDQSMGEMQIIGGDDLSTL 132
Cdd:cd06223    2 GRLLAEEIREDLL-EPDVVVGILRGGLPLAAALARALG-----------LPLAFIRKERKGPGRTPSEPYGLELPLGGDV 69

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|
gi 544346261 133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSDGFR 182
Cdd:cd06223   70 KGKRVLLVDDVIATGGTLLAAIELLKEAGAKVVGVAVLLDKPEGGARELA 119
Pribosyltran pfam00156
Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl ...
 46-177 8.90e-18

Phosphoribosyl transferase domain; This family includes a range of diverse phosphoribosyl transferase enzymes. This family includes: Adenine phosphoribosyl-transferase EC:2.4.2.7. Hypoxanthine-guanine-xanthine phosphoribosyl-transferase. Hypoxanthine phosphoribosyl-transferase EC:2.4.2.8. Ribose-phosphate pyrophosphokinase i EC:2.7.6.1. Amidophosphoribosyltransferase EC:2.4.2.14. Orotate phosphoribosyl-transferase EC:2.4.2.10. Uracil phosphoribosyl-transferase EC:2.4.2.9. Xanthine-guanine phosphoribosyl-transferase EC:2.4.2.22. In Arabidopsis, At the very N-terminus of this domain is the P-Loop NTPase domain.


Pssm-ID: 425489 [Multi-domain]  Cd Length: 150  Bit Score: 75.86  E-value: 8.90e-18
                          10        20        30        40        50        60        70        80
                  ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261   46 HGIIVDRIERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLKNisrnsdrfvsmKVDFIRLKSYRNDQSMGEMQIig 125
Cdd:pfam00156   8 NPAILKAVARLAAQINEDYGGKPDVVVGILRGGLPFAGILARRLDV-----------PLAFVRKVSYNPDTSEVMKTS-- 74

                          90       100       110       120       130
                  ....*....|....*....|....*....|....*....|....*....|..
gi 544346261  126 gDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSR 177
Cdd:pfam00156  75 -SALPDLKGKTVLIVDDILDTGGTLLKVLELLKNVGPKEVKIAVLIDKPAGT 125
PRK09162 PRK09162
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 53-184 9.41e-10

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 181675  Cd Length: 181  Bit Score: 55.25  E-value: 9.41e-10
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  53 IERLAKDIMKDIGYSDIMVLCVLKGGYKFCADLVEHLknisrnsdRFvSMKVDFIRLKSYRNDQSMGEMQIIGGDDLStL 132
Cdd:PRK09162  26 IDRMADEITADLADENPLVLCVMGGGLVFTGQLLPRL--------DF-PLEFDYLHATRYRNETTGGELVWKVKPRES-L 95

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|...
gi 544346261 133 AGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSRSD-GFRPD 184
Cdd:PRK09162  96 KGRTVLVVDDILDEGHTLAAIRDRCLEMGAAEVYSAVLVDKTHDRKAkPLKAD 148
PTZ00271 PTZ00271
hypoxanthine-guanine phosphoribosyltransferase; Provisional
 69-177 6.24e-09

hypoxanthine-guanine phosphoribosyltransferase; Provisional


Pssm-ID: 140297  Cd Length: 211  Bit Score: 53.49  E-value: 6.24e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  69 IMVLCVLKGGYKFCADLVEHLknisrnSDRFVSMKVDFIRLKSYRND-QSMGEMQIIGgDDLSTLAGKNVLIVEDVVGTG 147
Cdd:PTZ00271  59 LYLLCVLKGSFIFTADLARFL------ADEGVPVKVEFICASSYGTGvETSGQVRMLL-DVRDSVENRHILIVEDIVDSA 131

                         90       100       110
                 ....*....|....*....|....*....|
gi 544346261 148 RTMKALLSNIEKYKPNMIKVASLLVKRTSR 177
Cdd:PTZ00271 132 ITLQYLMRFMLAKKPASLKTVVLLDKPSGR 161
PRK15423 PRK15423
hypoxanthine phosphoribosyltransferase; Provisional
 42-177 6.25e-09

hypoxanthine phosphoribosyltransferase; Provisional


Pssm-ID: 185321  Cd Length: 178  Bit Score: 53.10  E-value: 6.25e-09
                         10        20        30        40        50        60        70        80
                 ....*....|....*....|....*....|....*....|....*....|....*....|....*....|....*....|
gi 544346261  42 VLIPHGIIVDRIERLAKDI---MKDIGySDIMVLCVLKGGYKFCADLVEHLKnisrnsdrfVSMKVDFIRLKSYRNDQSM 118
Cdd:PRK15423   7 VMIPEAEIKARIAELGRQIterYKDSG-SDMVLVGLLRGSFMFMADLCREVQ---------VSHEVDFMTASSYGSGMST 76

                         90       100       110       120       130
                 ....*....|....*....|....*....|....*....|....*....|....*....
gi 544346261 119 GEMQIIGGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKRTSR 177
Cdd:PRK15423  77 TRDVKILKDLDEDIRGKDVLIVEDIIDSGNTLSKVREILSLREPKSLAICTLLDKPSRR 135
PRK07322 PRK07322
adenine phosphoribosyltransferase; Provisional
 118-171 4.32e-05

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 180928  Cd Length: 178  Bit Score: 42.27  E-value: 4.32e-05
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|....*.
gi 544346261 118 MGEMQII--GGDDLSTLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLL 171
Cdd:PRK07322 102 TGKPQLLvlDGADAEKLKGKRVAIVDDVVSTGGTLTALERLVERAGGQVVAKAAIF 157
PRK09177 PRK09177
xanthine-guanine phosphoribosyltransferase; Validated
 104-153 9.47e-04

xanthine-guanine phosphoribosyltransferase; Validated


Pssm-ID: 236395  Cd Length: 156  Bit Score: 37.92  E-value: 9.47e-04
                         10        20        30        40        50
                 ....*....|....*....|....*....|....*....|....*....|...
gi 544346261 104 VDFIRLKSYrNDQSMGEMQI---IGGDdlstlaGKNVLIVEDVVGTGRTMKAL 153
Cdd:PRK09177  58 VDTVCISSY-DHDNQGELKVlkrAEGD------GEGFLVVDDLVDTGGTARAV 103
Apt COG0503
Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide ...
 124-159 3.32e-03

Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein [Nucleotide transport and metabolism]; Adenine/guanine phosphoribosyltransferase or related PRPP-binding protein is part of the Pathway/BioSystem: Purine salvage


Pssm-ID: 440269  Cd Length: 171  Bit Score: 36.59  E-value: 3.32e-03
                         10        20        30
                 ....*....|....*....|....*....|....*.
gi 544346261 124 IGGDDLStlAGKNVLIVEDVVGTGRTMKALLSNIEK 159
Cdd:COG0503  104 LHKDALK--PGDRVLIVDDLLATGGTAKAAIKLVEE 137
PRK08558 PRK08558
adenine phosphoribosyltransferase; Provisional
 133-155 3.52e-03

adenine phosphoribosyltransferase; Provisional


Pssm-ID: 181466 [Multi-domain]  Cd Length: 238  Bit Score: 36.89  E-value: 3.52e-03
                         10        20
                 ....*....|....*....|...
gi 544346261 133 AGKNVLIVEDVVGTGRTMKALLS 155
Cdd:PRK08558 175 KGDRVLIVDDIIRSGETQRALLD 197
PRK02277 PRK02277
orotate phosphoribosyltransferase-like protein; Provisional
 130-174 8.38e-03

orotate phosphoribosyltransferase-like protein; Provisional


Pssm-ID: 235023 [Multi-domain]  Cd Length: 200  Bit Score: 35.62  E-value: 8.38e-03
                         10        20        30        40
                 ....*....|....*....|....*....|....*....|....*
gi 544346261 130 STLAGKNVLIVEDVVGTGRTMKALLSNIEKYKPNMIKVASLLVKR 174
Cdd:PRK02277 136 ASVEGKRCVIVDDVITSGTTMKETIEYLKEHGGKPVAVVVLIDKS 180
 
Blast search parameters
Data Source: Precalculated data, version = cdd.v.3.21
Preset Options:Database: CDSEARCH/cdd   Low complexity filter: no  Composition Based Adjustment: yes   E-value threshold: 0.01

References:

  • Wang J et al. (2023), "The conserved domain database in 2023", Nucleic Acids Res.51(D)384-8.
  • Lu S et al. (2020), "The conserved domain database in 2020", Nucleic Acids Res.48(D)265-8.
  • Marchler-Bauer A et al. (2017), "CDD/SPARCLE: functional classification of proteins via subfamily domain architectures.", Nucleic Acids Res.45(D)200-3.
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